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Aliases for ZNF292 Gene

Aliases for ZNF292 Gene

  • Zinc Finger Protein 292 2 3 5
  • Putative Protein Product Of Nbla00365 3
  • 16 Zinc-Finger Domain Protein 3
  • Nbla00365 3
  • BA393I2.3 3
  • KIAA0530 4
  • ZFP292 3
  • ZN-16 3
  • Zn-15 3

External Ids for ZNF292 Gene

Previous GeneCards Identifiers for ZNF292 Gene

  • GC06P087913
  • GC06P087932
  • GC06P087857
  • GC06P087859
  • GC06P087920
  • GC06P085081

Summaries for ZNF292 Gene

Entrez Gene Summary for ZNF292 Gene

  • This gene encodes a growth hormone-dependent, zinc finger transcription factor that functions as a tumor suppressor. Naturally occurring mutations in this gene are associated with gastric cancer, colorectal cancer, and chronic lymphocytic leukemia. [provided by RefSeq, May 2017]

GeneCards Summary for ZNF292 Gene

ZNF292 (Zinc Finger Protein 292) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding. An important paralog of this gene is RLF.

UniProtKB/Swiss-Prot for ZNF292 Gene

  • May be involved in transcriptional regulation.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF292 Gene

Genomics for ZNF292 Gene

Regulatory Elements for ZNF292 Gene

Enhancers for ZNF292 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G087151 1.4 ENCODE dbSUPER 44.1 +1.6 1568 6.4 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF292 SLC35A1 SMIM8 LINC01590 CGA ENSG00000272008
GH06G087697 1.8 FANTOM5 ENCODE dbSUPER 21.5 +547.5 547525 6.6 CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 TBX21 SLC35A1 ZNF292 LINC01590 AKIRIN2 RARS2 SMIM8 GC06M087700 GC06P087659
GH06G087321 1.1 ENCODE 32.8 +169.8 169804 1.4 HDGF ARNT CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF292 LINC01590 SMIM8 SLC35A1 GJB7
GH06G087722 1.9 FANTOM5 Ensembl ENCODE dbSUPER 13.1 +571.5 571461 4.3 PKNOX1 FOXA2 CREB3L1 ARNT ARID4B SIN3A DMAP1 YY1 ZNF766 FOS ZNF292 AKIRIN2 C6orf163 SLC35A1 SMIM8 RARS2 LINC01590 ENSG00000238628 GC06P087742
GH06G087472 1.1 ENCODE 15.8 +320.3 320349 2.1 PKNOX1 CREB3L1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 SLC35A1 ZNF292 RARS2 GC06P087489
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF292 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF292 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000321873 67 201 IKZF1 MLLT1 EBF1 ZBTB40
ENSR00000199735 -832 1200 BACH1 SIN3A ASH2L MAX RBBP5 UBTF ZBTB40 POLR2A EED ZNF207

Genomic Location for ZNF292 Gene

Chromosome:
6
Start:
87,152,833 bp from pter
End:
87,264,196 bp from pter
Size:
111,364 bases
Orientation:
Plus strand

Genomic View for ZNF292 Gene

Genes around ZNF292 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF292 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF292 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF292 Gene

Proteins for ZNF292 Gene

  • Protein details for ZNF292 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60281-ZN292_HUMAN
    Recommended name:
    Zinc finger protein 292
    Protein Accession:
    O60281
    Secondary Accessions:
    • Q5W0B2
    • Q7Z3L7
    • Q9H8G3
    • Q9H8J4

    Protein attributes for ZNF292 Gene

    Size:
    2723 amino acids
    Molecular mass:
    304816 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14622.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14654.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAD97823.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAD97823.1; Type=Frameshift; Positions=637; Evidence={ECO:0000305}; Sequence=CAD97823.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZNF292 Gene

    Alternative splice isoforms for ZNF292 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF292 Gene

Post-translational modifications for ZNF292 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF292 Gene

Domains & Families for ZNF292 Gene

Gene Families for ZNF292 Gene

Protein Domains for ZNF292 Gene

Suggested Antigen Peptide Sequences for ZNF292 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60281

UniProtKB/Swiss-Prot:

ZN292_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF292: view

Function for ZNF292 Gene

Molecular function for ZNF292 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF292 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF292: view

Phenotypes for ZNF292 Gene

genes like me logo Genes that share phenotypes with ZNF292: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF292 Gene

Localization for ZNF292 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF292 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF292 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZNF292 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF292: view

Pathways & Interactions for ZNF292 Gene

SuperPathways for ZNF292 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF292 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with ZNF292: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF292 Gene

Drugs & Compounds for ZNF292 Gene

No Compound Related Data Available

Transcripts for ZNF292 Gene

Unigene Clusters for ZNF292 Gene

Zinc finger protein 292:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF292 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13
SP1: - -
SP2: -
SP3:
SP4: - - - - - - - - - -
SP5: - - - - - - -

Relevant External Links for ZNF292 Gene

GeneLoc Exon Structure for
ZNF292
ECgene alternative splicing isoforms for
ZNF292

Expression for ZNF292 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF292 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF292 Gene

This gene is overexpressed in Retina (46.3), Liver, secretome (11.7), and Platelet (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF292 Gene



Protein tissue co-expression partners for ZNF292 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF292 Gene:

ZNF292

SOURCE GeneReport for Unigene cluster for ZNF292 Gene:

Hs.485892

Evidence on tissue expression from TISSUES for ZNF292 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with ZNF292: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF292 Gene

Orthologs for ZNF292 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF292 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF292 34 35
  • 99.56 (n)
dog
(Canis familiaris)
Mammalia ZNF292 34 35
  • 93.42 (n)
cow
(Bos Taurus)
Mammalia ZNF292 34 35
  • 91.05 (n)
rat
(Rattus norvegicus)
Mammalia Zfp292 34
  • 85.23 (n)
mouse
(Mus musculus)
Mammalia Zfp292 34 16 35
  • 84.76 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF292 35
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF292 35
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF292 34 35
  • 73.43 (n)
lizard
(Anolis carolinensis)
Reptilia ZNF292 35
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znf292 34
  • 59.47 (n)
Str.7312 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.9913 34
zebrafish
(Danio rerio)
Actinopterygii znf292b 35
  • 32 (a)
OneToMany
znf292a 35
  • 31 (a)
OneToMany
Species where no ortholog for ZNF292 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF292 Gene

ENSEMBL:
Gene Tree for ZNF292 (if available)
TreeFam:
Gene Tree for ZNF292 (if available)

Paralogs for ZNF292 Gene

Paralogs for ZNF292 Gene

(3) SIMAP similar genes for ZNF292 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for ZNF292 Gene

genes like me logo Genes that share paralogs with ZNF292: view

Variants for ZNF292 Gene

Sequence variations from dbSNP and Humsavar for ZNF292 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs879255403 Uncertain significance 87,259,667(+) GACAG(-/AG)GAAAA reference, frameshift-variant
rs1000003309 -- 87,165,883(+) TTCCC(A/G)AGTAG intron-variant
rs1000016124 -- 87,163,363(+) GGAGA(A/G)TGGTG intron-variant
rs1000046648 -- 87,204,849(+) GTGAA(C/G)CACTG intron-variant, upstream-variant-2KB
rs1000048723 -- 87,219,177(+) CCTGC(A/G)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF292 Gene

Variant ID Type Subtype PubMed ID
esv2759453 CNV loss 17122850
esv2763585 CNV gain 21179565
esv3303905 CNV mobile element insertion 20981092
esv3327111 CNV insertion 20981092
nsv604114 CNV loss 21841781

Variation tolerance for ZNF292 Gene

Residual Variation Intolerance Score: 8.25% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.17; 69.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF292 Gene

Human Gene Mutation Database (HGMD)
ZNF292
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF292

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF292 Gene

Disorders for ZNF292 Gene

Relevant External Links for ZNF292

Genetic Association Database (GAD)
ZNF292
Human Genome Epidemiology (HuGE) Navigator
ZNF292
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF292

No disorders were found for ZNF292 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF292 Gene

Publications for ZNF292 Gene

  1. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4 64
  2. Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. (PMID: 21116278) Furney S.J. … . (Mol. Psychiatry 2011) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Frameshift mutations of a tumor suppressor gene ZNF292 in gastric and colorectal cancers with high microsatellite instability. (PMID: 27150435) Lee J.H. … Lee S.H. (APMIS 2016) 3 64
  5. Transposon mutagenesis identifies genes and evolutionary forces driving gastrointestinal tract tumor progression. (PMID: 25559195) Takeda H. … Jenkins N.A. (Nat. Genet. 2015) 3 64

Products for ZNF292 Gene

Sources for ZNF292 Gene

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