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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ZNF292 Gene

protein-coding GIFtS: 47
GCID: GC06P087920

zinc finger protein 292

Explore 1 disease affiliated with
ZNF292 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Zinc Finger Protein 292¹ ²		Zn-16¹
ZFP292¹ ²		16 Zinc-Finger Domain Protein²
Zn-15¹ ²		Nbla00365²
BA393I2.3¹		ZN-16²
KIAA0530¹ ³		Putative Protein Product Of Nbla00365²

External Ids:	HGNC: 18410¹	Entrez Gene: 23036²	Ensembl: ENSG00000188994⁷	UniProtKB: O60281³

Export aliases for ZNF292 gene to outside databases

Previous GC identifers: GC06P087913 GC06P087932 GC06P087857 GC06P087859 GC06P085081

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZN292_HUMAN, O60281

Function: May be involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_007299.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ZNF292 gene promoter:
AML1a Gfi-1 Evi-1 CREB N-Myc AREB6 deltaCREB HFH-1 Pax-4a
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for ZNF292

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF292

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q14.3 Ensembl cytogenetic band: 6q14.3 HGNC cytogenetic band: 6q15

ZNF292 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF292 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P087920: view genomic region (about GC identifiers)

Start:	87,862,551 bp from pter	End:	87,973,914 bp from pter
Size:	111,364 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZN292_HUMAN, O60281 (See protein sequence)

Recommended Name: Zinc finger protein 292

Size: 2723 amino acids; 304816 Da

Subcellular location: Nucleus (Probable)

Sequence caution: Sequence=BAB14622.1; Type=Erroneous initiation; Sequence=BAB14654.1; Type=Erroneous initiation;

Sequence=CAD97823.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAD97823.1;

Type=Frameshift; Positions=637; Sequence=CAD97823.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.

Potential poly-A sequence;

1 PDB 3D structure from and Proteopedia for ZNF292:

1X3C (3D)

Secondary accessions: Q5W0B2 Q7Z3L7 Q9H8G3 Q9H8J4

Alternative splicing: 2 isoforms: O60281-1 O60281-2 (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for ZNF292: NX_O60281

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O60281

ZNF292 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_055836.1

ENSEMBL proteins:

ENSP00000430569 ENSP00000358590 ENSP00000428925 ENSP00000342847 ENSP00000428857

ENSP00000428073

Human Recombinant Protein Products:

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	Uscn Proteins for ZNF292

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005634	nucleus	IEA	--

ZNF292 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for ZNF292

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZNF292 for domains About GeneDecksing

3 InterPro domains/families:

IPR015880 Znf_C2H2-like

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry O60281

ProtoNet protein and cluster: O60281

UniProtKB/Swiss-Prot: ZN292_HUMAN, O60281

Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family

Similarity: Contains 15 C2H2-type zinc fingers

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ZN292_HUMAN, O60281

Function: May be involved in transcriptional regulation

miRNA Products:		OriGene 3'-UTR Clone: ZNF292 Browse MicroRNA Expression Plasmids
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		hsa-miR-194* hsa-miR-323-3p hsa-miR-520e hsa-miR-300 hsa-miR-631 hsa-miR-1304 hsa-miR-3613-3p hsa-miR-200b

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF292

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	IEA	--
GO:0003676	nucleic acid binding	--	--
GO:0003677	DNA binding	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0016563	transcription activator activity	--	--

ZNF292 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZNF292

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

5/14 Interacting proteins for ZNF292 (O60281³ ENSP00000358590⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 14)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ALB	P02768³, ENSP00000295897⁴	I2D: score=1 STRING: ENSP00000295897
NFE2	Q16621³, ENSP00000312436⁴	I2D: score=1 STRING: ENSP00000312436
CDX2	Q99626³	I2D: score=1
EWSR1	Q01844³	I2D: score=1
GATA5	Q9BWX5³	I2D: score=1

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	--	--
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	--	--

ZNF292 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZNF292
Search CenterWatch for drugs/clinical trials and news about ZNF292 / ZN292

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ZNF292 gene:

NM_015021.1

Unigene Clusters for ZNF292:

Zinc finger protein 292

Hs.485892 [show with all ESTs], Hs.656621 [show with all ESTs]

Unigene Representative Sequences: NM_015021, BC040712

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000392985(uc003plk.3) ENST00000369577(uc003plm.4) ENST00000369578(uc003pll.1)

ENST00000518845 ENST00000339907 ENST00000496806 ENST00000524067 ENST00000485016

ENST00000466062

miRNA Products:		OriGene 3'-UTR Clone: ZNF292 Browse OriGene MicroRNA Expression Plasmids
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		8/88 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNF292 (see all 88):
		hsa-miR-194* hsa-miR-323-3p hsa-miR-520e hsa-miR-300 hsa-miR-631 hsa-miR-1304 hsa-miR-3613-3p hsa-miR-200b

		Browse SwitchGear 3'UTR luciferase reporter plasmids

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Additional cDNA sequence: BC040712.1

12 DOTS entries:

DT.99940040 DT.446298 DT.101983249 DT.99942551 DT.97822882 DT.91857141 DT.95338499 DT.121381963

DT.40292408 DT.91753429 DT.92006109 DT.92067573

24/199 AceView cDNA sequences (see all 199):

AA808183 AI474546 BM970468 BM668392 BQ421523 AA251587 AA766857 BG403320

AA284330 BM787762 AW163183 W85989 AU139835 AB011102 AL706712 BU742882

BU687167 AW157207 BM973468 AW295953 BQ005431 AK127835 BF223237 CB161174

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF292 About this scheme

ExUns:	1	^	2	^	3a	·	3b	·	3c	^	4	^	5a	·	5b	^	6	^	7	^	8	^	9	^	10a	·	10b	^	11	^	12	^	13
SP1:											-										-
SP2:											-
SP3:
SP4:											-				-		-		-		-		-		-		-		-		-
SP5:											-		-		-		-		-		-		-

ECgene alternative splicing isoforms for ZNF292

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZNF292 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTTAACCTA

About this image
See ZNF292 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF292

SOURCE GeneReport for Unigene clusters: Hs.485892 Hs.656621

SABiosciences Custom PCR Arrays for ZNF292

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF292

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for ZNF292 gene from 4/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ZNF292¹	zinc finger protein 292	73.59(n) 70.77(a)		421828 XM_419852.3 XP_419852.3
lizard (Anolis carolinensis)	Reptilia	ZNF292⁶	--	62(a)	1 ↔ 1	1(176447052-176472076)
African clawed frog (Xenopus laevis)	Amphibia	Xl.9913²	Xenopus laevis transcribed sequence with weak similarity more	80.24(n)		48044654
zebrafish (Danio rerio)	Actinopterygii	znf292b¹	zinc finger protein 292b	47.53(n) 38.16(a)		566732 NM_001030212.1 NP_001025383.1

ENSEMBL Gene Tree for ZNF292 (if available)
TreeFam Gene Tree for ZNF292 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ZNF292 gene

ZNF654² RLF² ENSG00000229729²

3 SIMAP similar genes for ZNF292 using alignment to 7 protein entries: ZN292_HUMAN (see all proteins):

Nbla00365 ZNF808 ZNF692

ZNF292 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs142812647^1,2		--	87863294(+)	`ACCTAC/TATTAT`	1	--	us2k¹		0	--	--	--	--
rs1925689^1,2	C,F,A,H,	--	87863351(+)	`CCCCTG/CAACCC`	1	--	us2k¹		14		NS EA NA WA CSA	784
rs146998684^1,2		--	87863357(+)	`AACCCC/TCATTT`	1	--	us2k¹		0	--	--	--	--
rs56847789^1,2	C,F,	--	87863387(+)	`TAGGTG/ATGGTG`	1	--	us2k¹		6		WA CSA NA	246
rs192368356^1,2		--	87863533(+)	`TGAAAA/CCTGGT`	1	--	us2k¹		0	--	--	--	--
rs182626720^1,2		--	87863865(+)	`AGAACA/GCTTTC`	1	--	us2k¹		0	--	--	--	--
rs112595956^1,2		--	87863940(+)	`TCCTTC/GTACTA`	1	--	us2k¹		1		CSA	1
rs141811383^1,2		--	87863969(+)	`AGAGTA/GAATGA`	1	--	us2k¹		0	--	--	--	--
rs187255949^1,2		--	87864019(+)	`TCTGTA/GGACTA`	1	--	us2k¹		0	--	--	--	--
rs79229676^1,2		--	87864057(+)	`GTCTAA/GTGCTC`	1	--	us2k¹		1		WA	118

HapMap Linkage Disequilibrium report for ZNF292 (87862551 - 87973914 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ZNF292
1 CNV: 3626
Human Gene Mutation Database (HGMD): ZNF292

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF292

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ZNF292 for disorders About GeneDecksing

1 disease for ZNF292: About MalaCards

alzheimer's disease

Human Genome Epidemiology (HuGE) Navigator: ZNF292 (1 document)

Export disorders for ZNF292 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZNF292 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with ZNF292)

Utopia: connect your pdf to the dynamic
world of online information

Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)^{1, 2, 3} Nagase T....Ohara O. (1998)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
A catalogue of putative HIV-1 protease host cell subst rates. (PubMed id 22944692)¹ Impens F....Gevaert K. (2012)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. (PubMed id 21116278)¹ Furney S.J....Lovestone S. (2010)
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)² Mayya V.... Han D.K. (2009)
Growth hormone transcription factor ZN-16 genomic coding regions are composed of a single exon and are evolutionarily conserved in mammals. (PubMed id 16303260)¹ Flynn M.P. and Hurley D.L. (2006)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
Humoral detection of leukaemia-associated antigens in presentation acute myeloid leukaemia. (PubMed id 16112646)¹ Guinn B.-A.... Mufti G.J. (2005)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)² Mungall A.J.... Beck S. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 23036	HGNC: 18410	AceView: ZNF292	Ensembl:ENSG00000188994	euGenes: HUgn23036
ECgene: ZNF292	H-InvDB: ZNF292

(According to HUGE)
About This Section

HUGE: KIAA0530

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ZNF292	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZNF292 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ZNF292 gene:
Search GeneIP for patents involving ZNF292

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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ZNF292 Gene

zinc finger protein 292

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ZNF292 Gene

zinc finger protein 292

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