Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF287 Gene

Aliases for ZNF287 Gene

  • Zinc Finger Protein 287 2 3 5
  • Zinc Finger Protein With KRAB And SCAN Domains 13 3 4
  • ZKSCAN13 3 4
  • ZSCAN45 3

External Ids for ZNF287 Gene

Previous GeneCards Identifiers for ZNF287 Gene

  • GC17M016816
  • GC17M017565
  • GC17M016397
  • GC17M016655
  • GC17M016395
  • GC17M016320
  • GC17M016453

Summaries for ZNF287 Gene

Entrez Gene Summary for ZNF287 Gene

  • This gene encodes a member of the krueppel family of zinc finger proteins, suggesting a role as a transcription factor. Its specific function has not been determined. This gene is located near the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZNF287 Gene

ZNF287 (Zinc Finger Protein 287) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF483.

UniProtKB/Swiss-Prot for ZNF287 Gene

  • May be involved in transcriptional regulation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF287 Gene

Genomics for ZNF287 Gene

Regulatory Elements for ZNF287 Gene

Enhancers for ZNF287 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F017040 1.1 FANTOM5 ENCODE 13.5 -474.7 -474658 6.1 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 CBX5 ZNF143 FOS FLCN PLD6 MPRIP-AS1 SMCR5 ZNF624 MPRIP ZNF287 COPS3 RNU6-767P MED9
GH17F016535 1.2 FANTOM5 Ensembl ENCODE 7.6 +33.0 33005 2.4 HDGF PKNOX1 MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 LRRC75A TBC1D26 UPF3AP1 ZNF287 KRT16P6 CCDC144A ZNF624 GC17M016532 LOC105371554
GH17F016568 0.6 ENCODE 7.5 0.0 -35 1.2 PKNOX1 ZNF76 KLF17 BMI1 GLI4 ZNF2 SCRT2 RCOR1 ZNF843 ZFP69B ZNF287 GC17P016578
GH17F016472 0.3 FANTOM5 1.8 +96.7 96674 0.3 LRRC75A-AS1 NCOR1 ZNF624 PIGL CENPV ZNF287 ZSWIM7 TTC19 GC17M016479 PIR35161
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZNF287 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF287 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001341701 305 1399 PKNOX1 ZNF76 KLF17 BMI1 GLI4 ZNF2 SCRT2 RCOR1 ZNF843 ZFP69B

Genomic Location for ZNF287 Gene

Chromosome:
17
Start:
16,549,913 bp from pter
End:
16,569,206 bp from pter
Size:
19,294 bases
Orientation:
Minus strand

Genomic View for ZNF287 Gene

Genes around ZNF287 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF287 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF287 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF287 Gene

Proteins for ZNF287 Gene

  • Protein details for ZNF287 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBT7-ZN287_HUMAN
    Recommended name:
    Zinc finger protein 287
    Protein Accession:
    Q9HBT7
    Secondary Accessions:
    • Q6IAG1

    Protein attributes for ZNF287 Gene

    Size:
    754 amino acids
    Molecular mass:
    87565 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF287 Gene

Post-translational modifications for ZNF287 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF287 Gene

Domains & Families for ZNF287 Gene

Gene Families for ZNF287 Gene

Suggested Antigen Peptide Sequences for ZNF287 Gene

Graphical View of Domain Structure for InterPro Entry

Q9HBT7

UniProtKB/Swiss-Prot:

ZN287_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 14 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
  • Contains 1 SCAN box domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 14 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF287: view

Function for ZNF287 Gene

Molecular function for ZNF287 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF287 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF287: view
genes like me logo Genes that share phenotypes with ZNF287: view

Animal Models for ZNF287 Gene

MGI Knock Outs for ZNF287:

Animal Model Products

miRNA for ZNF287 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF287 Gene

Localization for ZNF287 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF287 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF287 Gene COMPARTMENTS Subcellular localization image for ZNF287 gene
Compartment Confidence
nucleus 5
golgi apparatus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF287 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF287: view

Pathways & Interactions for ZNF287 Gene

SuperPathways for ZNF287 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF287: view

Pathways by source for ZNF287 Gene

2 Reactome pathways for ZNF287 Gene

Gene Ontology (GO) - Biological Process for ZNF287 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0042035 regulation of cytokine biosynthetic process IEA --
GO:0045893 positive regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF287: view

No data available for SIGNOR curated interactions for ZNF287 Gene

Transcripts for ZNF287 Gene

Unigene Clusters for ZNF287 Gene

Zinc finger protein 287:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF287 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8
SP1: - - -
SP2: - -
SP3: - -
SP4: - -
SP5: - - - - -
SP6: -

Relevant External Links for ZNF287 Gene

GeneLoc Exon Structure for
ZNF287
ECgene alternative splicing isoforms for
ZNF287

Expression for ZNF287 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF287 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of ZNF287 Gene:

ZNF287

SOURCE GeneReport for Unigene cluster for ZNF287 Gene:

Hs.99724
genes like me logo Genes that share expression patterns with ZNF287: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ZNF287 Gene

Orthologs for ZNF287 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF287 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF287 34 35
  • 99.74 (n)
dog
(Canis familiaris)
Mammalia ZNF287 34 35
  • 91.75 (n)
rat
(Rattus norvegicus)
Mammalia Zfp287 34
  • 85.97 (n)
cow
(Bos Taurus)
Mammalia ZNF287 34
  • 85.34 (n)
ZNF135 35
  • 43 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp287 34 16 35
  • 83.27 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 50 (a)
OneToMany
-- 35
  • 49 (a)
OneToMany
-- 35
  • 48 (a)
OneToMany
-- 35
  • 46 (a)
OneToMany
-- 35
  • 45 (a)
OneToMany
-- 35
  • 45 (a)
OneToMany
-- 35
  • 45 (a)
OneToMany
-- 35
  • 43 (a)
OneToMany
-- 35
  • 42 (a)
OneToMany
-- 35
  • 42 (a)
OneToMany
-- 35
  • 41 (a)
OneToMany
-- 35
  • 41 (a)
OneToMany
-- 35
  • 41 (a)
OneToMany
-- 35
  • 41 (a)
OneToMany
-- 35
  • 39 (a)
OneToMany
-- 35
  • 39 (a)
OneToMany
-- 35
  • 39 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6654 36
  • 40 (a)
CG2120 36
  • 36 (a)
CG8301 36
  • 32 (a)
CG10543 36
  • 30 (a)
worm
(Caenorhabditis elegans)
Secernentea Y55F3AM.14 36
  • 36 (a)
Species where no ortholog for ZNF287 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ZNF287 Gene

ENSEMBL:
Gene Tree for ZNF287 (if available)
TreeFam:
Gene Tree for ZNF287 (if available)

Paralogs for ZNF287 Gene

Paralogs for ZNF287 Gene

(426) SIMAP similar genes for ZNF287 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF287: view

Variants for ZNF287 Gene

Sequence variations from dbSNP and Humsavar for ZNF287 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs193920744 Uncertain significance 16,553,049(-) CTGGA(C/G)AGAAG intron-variant, reference, missense
rs10401059 -- 16,562,359(+) cacat(A/T)aaaaa intron-variant
rs10491106 -- 16,551,597(+) AGTTA(C/T)GTTTT intron-variant, utr-variant-3-prime
rs111315254 -- 16,568,426(+) CCTTT(C/T)ACTAT intron-variant, utr-variant-5-prime
rs111328461 -- 16,570,282(+) GCGCC(A/G)TGGCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNF287 Gene

Variant ID Type Subtype PubMed ID
esv2715702 CNV deletion 23290073
esv3640103 CNV gain 21293372
nsv1063764 CNV loss 25217958

Variation tolerance for ZNF287 Gene

Residual Variation Intolerance Score: 14.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.46; 43.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF287 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF287

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF287 Gene

Disorders for ZNF287 Gene

Relevant External Links for ZNF287

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF287

No disorders were found for ZNF287 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF287 Gene

Publications for ZNF287 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. Integrated analysis of whole-genome paired-end and mate-pair sequencing data for identifying genomic structural variations in multiple myeloma. (PMID: 25288879) Yang R. … Qin Z.S. (Cancer Inform 2014) 3 64
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  4. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 4 64
  5. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3 64

Products for ZNF287 Gene

Sources for ZNF287 Gene

Content
Loading form....