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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF287 Gene

protein-coding   GIFtS: 48
GCID: GC17M016453

zinc finger protein 287

 Explore 1 disease affiliated with
ZNF287 via our new
 Human Malady Compendium 
Biological research products
for ZNF287
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Zinc Finger Protein 2871 2
ZKSCAN131 2 3
ZSCAN451 2
Zinc Finger Protein With KRAB And SCAN Domains 132 3

External Ids:    HGNC: 135021   Entrez Gene: 573362   Ensembl: ENSG000001410407   UniProtKB: Q9HBT73   
ORGUL members:         
NONCODE:n340530    

Export aliases for ZNF287 gene to outside databases

Previous GC identifers: GC17M016816 GC17M017565 GC17M016397 GC17M016655 GC17M016395 GC17M016320


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ZNF287:
This gene encodes a member of the krueppel family of zinc finger proteins, suggesting a role as a transcription factor.
Its specific function has not been determined. This gene is located near the Smith-Magenis syndrome region on
chromosome 17. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ZN287_HUMAN, Q9HBT7
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010718.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF287 gene promoter:
         Nkx2-2   Pax-2   Pax-2a   CUTL1   HNF-3beta   NF-AT   C/EBPalpha   CHOP-10   SEF-1 (1)   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF287 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF287

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF287


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p11.2   Ensembl cytogenetic band:  17p11.2   HGNC cytogenetic band: 17p11.2

ZNF287 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF287 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M016453:  view genomic region     (about GC identifiers)

Start:
16,453,631 bp from pter      End:
16,472,520 bp from pter
Size:
18,890 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZN287_HUMAN, Q9HBT7 (See protein sequence)
Recommended Name: Zinc finger protein 287  
Size: 754 amino acids; 87565 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: Q6IAG1

Explore the universe of human proteins at neXtProt for ZNF287: NX_Q9HBT7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9HBT7

  • ZNF287 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_065704.2  
    ENSEMBL proteins: 
     ENSP00000379168   ENSP00000379169   ENSP00000406051  
    Reactome Protein details: Q9HBT7
    Human Recombinant Protein Products: 
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    Novus Biologicals ZNF287 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ZNF287

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    ZNF287 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for ZNF287


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ZNF287 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR008916 Retrov_capsid_C
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9HBT7

    ProtoNet protein and cluster: Q9HBT7

    3 Blocks protein families:
    IPB001909 KRAB box
    IPB003309 Transcriptional regulator SCAN
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZN287_HUMAN, Q9HBT7
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 14 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain
    Similarity: Contains 1 SCAN box domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ZN287_HUMAN, Q9HBT7
    Function: May be involved in transcriptional regulation

    miRNA
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    hsa-miR-892b hsa-miR-125a-3p hsa-miR-25 hsa-miR-3653 hsa-miR-449a hsa-miR-320e hsa-miR-4325 hsa-miR-23a
    SwitchGear 3'UTR luciferase reporter plasmidZNF287 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF287 (see all 7)
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    OriGene siRNA: ZNF287
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF287

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0008270zinc ion binding IEA--


    ZNF287 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ZNF287:
     Increased gamma-H2AX phosphory 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Generic Transcription Pathway
    Generic Transcription Pathway1.00
    Gene Expression0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2        Reactome Pathways for ZNF287
        Generic Transcription Pathway
    Gene Expression



    ZNF287 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF287

    1 Interacting protein for ZNF287 (Q9HBT73) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TMEM62Q0P6H93I2D: score=3 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0016032viral reproduction IEA--
    GO:0042035regulation of cytokine biosynthetic process IEA--
    GO:0045893positive regulation of transcription, DNA-dependent IEA--


    ZNF287 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF287
    Search CenterWatch for drugs/clinical trials and news about ZNF287 / ZN287 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF287 gene: 
    NM_020653.2  

    Unigene Cluster for ZNF287:

    Zinc finger protein 287
    Hs.99724  [show with all ESTs]
    Unigene Representative Sequence: NM_020653
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000395824(uc021trd.1) ENST00000395825(uc002gqi.2) ENST00000498796
    ENST00000578303 ENST00000448349 ENST00000461555

    miRNA
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    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNF287 (see all 20):
    hsa-miR-892b hsa-miR-125a-3p hsa-miR-25 hsa-miR-3653 hsa-miR-449a hsa-miR-320e hsa-miR-4325 hsa-miR-23a
    SwitchGear 3'UTR luciferase reporter plasmidZNF287 3' UTR sequence
    Inhib. RNA
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    Clone
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF287
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF287

    Additional cDNA sequence: 

    AF027140.1 AF217227.1 BC032002.1 BC041159.1 BC057791.1 BC101487.1 BC113363.1 CR457194.1 
    CR749683.1 

    6 DOTS entries:

    DT.302926  DT.120937495  DT.95260862  DT.120904017  DT.102821586  DT.40119839 

    24/44 AceView cDNA sequences (see all 44):

    AW591875 BC032002 BP375528 Z46024 AA417757 AL359578 CR457194 BX095331 
    AF217227 BI764281 NM_020653 BQ065231 AI302995 BC041159 CR749683 CD677577 
    Z41639 N49113 BP339969 AJ230816 AU130954 AF027140 BM685282 BE501785 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF287 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8
    SP1:              -     -     -                                                         
    SP2:                    -     -                                                         
    SP3:              -     -                                                               
    SP4:              -     -                                                               
    SP5:              -     -     -     -     -                                             


    ECgene alternative splicing isoforms for ZNF287

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF287 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See ZNF287 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF287

    SOURCE GeneReport for Unigene cluster: Hs.99724
        SABiosciences Custom PCR Arrays for ZNF287
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF287

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ZNF287 gene from 2/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia ZNF7746
    --
    (see all 6)
    --
    52(a)
    48(a)
    (see all 6)
    possible ortholog
    1 ↔ many
    (see all 6)
    2(199167583-199168815)
    GL343220.1(2330463-2336819)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG66543   -- 40(a)
    (best of 4)
      88E3   --


    ENSEMBL Gene Tree for ZNF287 (if available)
    TreeFam Gene Tree for ZNF287 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF287 gene
    ZNF5702  ZNF1812  ZFP282  ZNF4712  ZNF72  ZNF2502  ZNF8792  ZNF3022  
    ZNF354C2  ZNF742  ZNF5832  ZFP902  ZNF1892  ZNF354A2  ZNF354B2  ZNF1352  
    ZNF5682  ZNF342  ZNF5272  ZNF82  ZNF5692  ZNF4702  
    18/422 SIMAP similar genes for ZNF287 using alignment to 3 protein entries:     ZN287_HUMAN (see all proteins) (see all similar genes):
    ZNF323    LOC100128510    ZNF485    HZF30    HZF36    GLI4
    SCAND1    ZFS-1    ZNF146    ZNF852    ZNF883    DKFZp666M039
    DKFZp762K012    ZFP2    ZNF286B    DKFZp547L155    DKFZp686L0787    DKFZp686N14223

    ZNF287 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/333 NCBI SNPs in ZNF287 are shown (see all 333    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1929596431,2
    --16453370(+) GTTCTC/TAGAAT 1 -- ds50010--------
    rs1848472661,2
    --16453423(+) ACAATA/GGTATT 1 -- ds50010--------
    rs1881623801,2
    --16453481(+) ACAAAC/TCCAGT 1 -- ds50010--------
    rs5536651,2
    C,F,O,A,H,--16453751(-) TTTTAA/GTGGAG 1 -- ut3129Minor allele frequency- G:0.09MN NA NS EA WA CSA 2480
    rs1910927981,2
    --16453771(+) TTCCCC/TGACCC 1 -- ut310--------
    rs1489835041,2
    --16453796(+) ATTCAC/GATCTA 1 -- ut310--------
    rs1166904161,2
    --16453839(+) CTACAC/TTATCA 1 -- ut311Minor allele frequency- T:0.01WA 118
    rs1836458791,2
    --16453862(+) TCTCTC/TGGGAT 1 -- ut310--------
    rs169598201,2
    C,F,H,--16453907(+) GCTTAT/CGCTCA 1 -- ut3122Minor allele frequency- C:0.17NA NS EA WA 2454
    rs1437596341,2
    --16453914(+) CTCAAC/TCCATG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ZNF287 (16453631 - 16472520 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ZNF287: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF287
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF287

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZNF287 for disorders           About GeneDecksing

    1 disease for ZNF287:    About MalaCards
    smith-magenis syndrome


    Export disorders for ZNF287 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF287 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF287)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    3. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
    4. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    6. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
    7. The biology of the mammalian Kruppel-like family of transcription factors. (PubMed id 11137451)1 Dang D.T....Yang V.W. (2000)
    8. Zinc fingers: DNA binding and protein-protein interactions. (PubMed id 11021307)1 Leon O. and Roth M. (2000)
    9. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57336 HGNC: 13502 AceView: ZNF287 Ensembl:ENSG00000141040 euGenes: HUgn57336
    ECgene: ZNF287 H-InvDB: ZNF287

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF287 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF287 gene:
    Search GeneIP for patents involving ZNF287

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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