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Aliases for ZNF287 Gene

Aliases for ZNF287 Gene

  • Zinc Finger Protein 287 2 3 5
  • Zinc Finger Protein With KRAB And SCAN Domains 13 3 4
  • ZKSCAN13 3 4
  • ZSCAN45 3

External Ids for ZNF287 Gene

Previous GeneCards Identifiers for ZNF287 Gene

  • GC17M016816
  • GC17M017565
  • GC17M016397
  • GC17M016655
  • GC17M016395
  • GC17M016320
  • GC17M016453

Summaries for ZNF287 Gene

Entrez Gene Summary for ZNF287 Gene

  • This gene encodes a member of the krueppel family of zinc finger proteins, suggesting a role as a transcription factor. Its specific function has not been determined. This gene is located near the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZNF287 Gene

ZNF287 (Zinc Finger Protein 287) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF483.

UniProtKB/Swiss-Prot for ZNF287 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF287 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF287 Gene

Genomics for ZNF287 Gene

Regulatory Elements for ZNF287 Gene

Enhancers for ZNF287 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H017040 1.6 FANTOM5 ENCODE dbSUPER 13.5 -474.7 -474658 6 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 MPRIP-AS1 FLCN PIGL PLD6 NCOR1 MPRIP SMCR5 LOC100419436 ZNF624 ZNF287
GH17H016484 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.3 +81.0 81043 7 HDAC1 NFIB ZSCAN4 KLF17 TCF12 GLIS2 GATA2 SCRT2 EGR2 MCM3 ZNF286A ENSG00000266538 PPIAP53 PIGL MPRIP-AS1 MEIS3P1 ENSG00000265519 TVP23C CDRT4 TTC19
GH17H016535 1.6 FANTOM5 Ensembl ENCODE 7.7 +33.0 33005 2 HDGF ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 ZNF207 ZNF143 MPRIP-AS1 LRRC75A PIGL NCOR1 ZNF287 KRT16P6 CCDC144A ZNF624 GC17M016532 LOC105371554
GH17H016568 0.9 ENCODE 7.4 0.0 -35 1 PKNOX1 ZNF76 KLF17 GLI4 BMI1 ZNF2 RFX5 SCRT2 ZNF143 RCOR1 ZNF286A ZNF287 GC17P016578
GH17H016472 0.5 FANTOM5 dbSUPER 1.8 +96.7 96674 0 LRRC75A-AS1 NCOR1 ZNF624 PIGL CENPV ZNF287 ZSWIM7 TTC19 GC17M016479 PIR35161
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF287 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF287 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000091789 6 800 PKNOX1 ZNF76 KLF17 GLI4 BMI1 ZNF2 RFX5 SCRT2 ZNF143 RCOR1

Genomic Location for ZNF287 Gene

Chromosome:
17
Start:
16,549,913 bp from pter
End:
16,569,206 bp from pter
Size:
19,294 bases
Orientation:
Minus strand

Genomic View for ZNF287 Gene

Genes around ZNF287 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF287 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF287 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF287 Gene

Proteins for ZNF287 Gene

  • Protein details for ZNF287 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBT7-ZN287_HUMAN
    Recommended name:
    Zinc finger protein 287
    Protein Accession:
    Q9HBT7
    Secondary Accessions:
    • Q6IAG1

    Protein attributes for ZNF287 Gene

    Size:
    754 amino acids
    Molecular mass:
    87565 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF287 Gene

Post-translational modifications for ZNF287 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF287 Gene

Domains & Families for ZNF287 Gene

Gene Families for ZNF287 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for ZNF287 Gene

Graphical View of Domain Structure for InterPro Entry

Q9HBT7

UniProtKB/Swiss-Prot:

ZN287_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF287: view

Function for ZNF287 Gene

Molecular function for ZNF287 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF287 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF287: view
genes like me logo Genes that share phenotypes with ZNF287: view

Animal Models for ZNF287 Gene

MGI Knock Outs for ZNF287:

Animal Model Products

CRISPR Products

miRNA for ZNF287 Gene

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZNF287
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF287 Gene

Localization for ZNF287 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF287 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF287 gene
Compartment Confidence
nucleus 5
golgi apparatus 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF287 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF287: view

Pathways & Interactions for ZNF287 Gene

SuperPathways for ZNF287 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF287: view

Pathways by source for ZNF287 Gene

2 Reactome pathways for ZNF287 Gene

Gene Ontology (GO) - Biological Process for ZNF287 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0042035 regulation of cytokine biosynthetic process IEA --
GO:0045893 positive regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF287: view

No data available for SIGNOR curated interactions for ZNF287 Gene

Drugs & Compounds for ZNF287 Gene

No Compound Related Data Available

Transcripts for ZNF287 Gene

Unigene Clusters for ZNF287 Gene

Zinc finger protein 287:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZNF287
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF287 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8
SP1: - - -
SP2: - -
SP3: - -
SP4: - -
SP5: - - - - -
SP6: -

Relevant External Links for ZNF287 Gene

GeneLoc Exon Structure for
ZNF287
ECgene alternative splicing isoforms for
ZNF287

Expression for ZNF287 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF287 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of ZNF287 Gene:

ZNF287

SOURCE GeneReport for Unigene cluster for ZNF287 Gene:

Hs.99724

Evidence on tissue expression from TISSUES for ZNF287 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with ZNF287: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF287 Gene

Orthologs for ZNF287 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF287 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF287 33 34
  • 99.74 (n)
dog
(Canis familiaris)
Mammalia ZNF287 33 34
  • 91.75 (n)
rat
(Rattus norvegicus)
Mammalia Zfp287 33
  • 85.97 (n)
cow
(Bos Taurus)
Mammalia ZNF287 33
  • 85.34 (n)
ZNF135 34
  • 43 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp287 33 16 34
  • 83.27 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 50 (a)
OneToMany
-- 34
  • 49 (a)
OneToMany
-- 34
  • 48 (a)
OneToMany
-- 34
  • 46 (a)
OneToMany
-- 34
  • 45 (a)
OneToMany
-- 34
  • 45 (a)
OneToMany
-- 34
  • 45 (a)
OneToMany
-- 34
  • 43 (a)
OneToMany
-- 34
  • 42 (a)
OneToMany
-- 34
  • 42 (a)
OneToMany
-- 34
  • 41 (a)
OneToMany
-- 34
  • 41 (a)
OneToMany
-- 34
  • 41 (a)
OneToMany
-- 34
  • 41 (a)
OneToMany
-- 34
  • 39 (a)
OneToMany
-- 34
  • 39 (a)
OneToMany
-- 34
  • 39 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6654 35
  • 40 (a)
CG2120 35
  • 36 (a)
CG8301 35
  • 32 (a)
CG10543 35
  • 30 (a)
worm
(Caenorhabditis elegans)
Secernentea Y55F3AM.14 35
  • 36 (a)
Species where no ortholog for ZNF287 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ZNF287 Gene

ENSEMBL:
Gene Tree for ZNF287 (if available)
TreeFam:
Gene Tree for ZNF287 (if available)

Paralogs for ZNF287 Gene

Paralogs for ZNF287 Gene

(426) SIMAP similar genes for ZNF287 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF287: view

Variants for ZNF287 Gene

Sequence variations from dbSNP and Humsavar for ZNF287 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs193920744 Uncertain significance 16,553,049(-) CTGGA(C/G)AGAAG intron-variant, reference, missense
rs1000217500 -- 16,548,726(+) ACCTG(C/G)GAGGC intron-variant, downstream-variant-500B, utr-variant-3-prime
rs1000433415 -- 16,559,051(+) ATATA(C/T)ATAGT intron-variant
rs1000814442 -- 16,559,952(+) TATAT(A/G)TATAT intron-variant
rs1001109514 -- 16,547,118(+) CAGCC(C/T)TAAAG intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF287 Gene

Variant ID Type Subtype PubMed ID
esv2715702 CNV deletion 23290073
esv3640103 CNV gain 21293372
nsv1063764 CNV loss 25217958

Variation tolerance for ZNF287 Gene

Residual Variation Intolerance Score: 14.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.46; 43.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF287 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF287

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF287 Gene

Disorders for ZNF287 Gene

Relevant External Links for ZNF287

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF287

No disorders were found for ZNF287 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF287 Gene

Publications for ZNF287 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  2. Integrated analysis of whole-genome paired-end and mate-pair sequencing data for identifying genomic structural variations in multiple myeloma. (PMID: 25288879) Yang R … Qin ZS (Cancer informatics 2014) 3 60
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 60
  4. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 4 60
  5. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U … Wanker EE (Cell 2005) 3 60

Products for ZNF287 Gene

Sources for ZNF287 Gene

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