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Aliases for ZNF286B Gene

Aliases for ZNF286B Gene

  • Zinc Finger Protein 286B 2 3 5
  • Zinc Finger 286C Pseudogene 2 3
  • Zinc Finger Protein 590 2 3
  • ZNF286C 3 4
  • ZNF286L 3 4
  • Putative Zinc Finger Protein 286B 3
  • Zinc Finger Protein 286-Like 2
  • ZNF590 3

External Ids for ZNF286B Gene

Previous HGNC Symbols for ZNF286B Gene

  • ZNF286L
  • ZNF286C

Previous GeneCards Identifiers for ZNF286B Gene

  • GC17U900825
  • GC17M018511
  • GC17M018561

Summaries for ZNF286B Gene

GeneCards Summary for ZNF286B Gene

ZNF286B (Zinc Finger Protein 286B) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF286A.

UniProtKB/Swiss-Prot for ZNF286B Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF286B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF286B Gene

Genomics for ZNF286B Gene

Regulatory Elements for ZNF286B Gene

Enhancers for ZNF286B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H017748 2 FANTOM5 Ensembl ENCODE dbSUPER 45.2 +928.4 928427 10.3 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF143 FOS ZNF286B ENSG00000264885 RAI1 USP32P2 LOC100419436 FOXO3B MPRIP-AS1 SMCR5 DRG2 ENSG00000273018
GH17H018087 1.2 ENCODE 48.4 +594.0 594046 1.9 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 NFYC ZC3H11A ENSG00000264885 DRG2 ZNF286B RAI1 FOXO3B LOC100419436 FAM106A SMCR5 SMCR8 ENSG00000273018
GH17H019254 0.9 dbSUPER 48.5 -572.7 -572696 1.7 ZNF493 ZFP64 ZNF121 ZNF302 KLF7 ZNF202 SP3 ZC3H11A REST ZNF623 ENSG00000264885 FOXO3B MAPK7 FAM106A SMCR8 CCDC144B ZNF286B ENSG00000262202 ENSG00000273018 ENSG00000264932
GH17H018410 1.2 ENCODE dbSUPER 28.6 +271.0 271013 1.5 SIN3A GLI4 ZNF2 ZNF302 KLF7 SP3 YY2 REST TSHZ1 ZNF488 FOXO3B MAPK7 DRG2 SMCR8 ZNF286B ENSG00000264885 SMCR5 SHMT1 ENSG00000262202 NOS2P2
GH17H019645 1.7 Ensembl ENCODE dbSUPER 20.1 -966.9 -966899 7.8 HDGF PKNOX1 FOXA2 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B ENSG00000231477 ZNF286B RNF112 LINC01984 ENSG00000267075 ENSG00000265916 LINC02088 ENSG00000264981 ENSG00000266925 LOC105371580
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF286B on UCSC Golden Path with GeneCards custom track

Promoters for ZNF286B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000092111 62 1601 ATF1 ZNF76 SIN3A BRCA1 ZEB1 ZNF121 GLIS2 EGR1 ZNF366 SCRT2

Genomic Locations for ZNF286B Gene

Genomic Locations for ZNF286B Gene
chr17:18,658,429-18,682,262
(GRCh38/hg38)
Size:
23,834 bases
Orientation:
Minus strand
chr17:18,561,742-18,585,575
(GRCh37/hg19)

Genomic View for ZNF286B Gene

Genes around ZNF286B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF286B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF286B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF286B Gene

Proteins for ZNF286B Gene

  • Protein details for ZNF286B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CG31-Z286B_HUMAN
    Recommended name:
    Putative zinc finger protein 286B
    Protein Accession:
    P0CG31

    Protein attributes for ZNF286B Gene

    Size:
    522 amino acids
    Molecular mass:
    59572 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF286B Gene

Post-translational modifications for ZNF286B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF286B Gene

No data available for DME Specific Peptides for ZNF286B Gene

Domains & Families for ZNF286B Gene

Gene Families for ZNF286B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF286B Gene

Suggested Antigen Peptide Sequences for ZNF286B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0CG31

UniProtKB/Swiss-Prot:

Z286B_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF286B: view

Function for ZNF286B Gene

Molecular function for ZNF286B Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF286B Gene

Gene Ontology (GO) - Molecular Function for ZNF286B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF286B: view

Phenotypes for ZNF286B Gene

GenomeRNAi human phenotypes for ZNF286B:
genes like me logo Genes that share phenotypes with ZNF286B: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF286B Gene

Localization for ZNF286B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF286B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF286B gene
Compartment Confidence
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF286B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF286B: view

Pathways & Interactions for ZNF286B Gene

SuperPathways for ZNF286B Gene

No Data Available

Interacting Proteins for ZNF286B Gene

Gene Ontology (GO) - Biological Process for ZNF286B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF286B: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF286B Gene

Drugs & Compounds for ZNF286B Gene

No Compound Related Data Available

Transcripts for ZNF286B Gene

mRNA/cDNA for ZNF286B Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF286B Gene

Zinc finger protein 286B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF286B Gene

No ASD Table

Relevant External Links for ZNF286B Gene

GeneLoc Exon Structure for
ZNF286B
ECgene alternative splicing isoforms for
ZNF286B

Expression for ZNF286B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF286B Gene

mRNA differential expression in normal tissues according to GTEx for ZNF286B Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.1).

NURSA nuclear receptor signaling pathways regulating expression of ZNF286B Gene:

ZNF286B

SOURCE GeneReport for Unigene cluster for ZNF286B Gene:

Hs.534279
genes like me logo Genes that share expression patterns with ZNF286B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF286B Gene

Orthologs for ZNF286B Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF286B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF286A 34
  • 86 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 79 (a)
OneToMany
cow
(Bos Taurus)
Mammalia ZNF286A 34
  • 77 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Zfp286 34
  • 72 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 59 (a)
OneToMany
Species where no ortholog for ZNF286B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF286B Gene

ENSEMBL:
Gene Tree for ZNF286B (if available)
TreeFam:
Gene Tree for ZNF286B (if available)

Paralogs for ZNF286B Gene

(513) SIMAP similar genes for ZNF286B Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for ZNF286B Gene

genes like me logo Genes that share paralogs with ZNF286B: view

Variants for ZNF286B Gene

Sequence variations from dbSNP and Humsavar for ZNF286B Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000253512 -- 18,678,729(+) TTCAC(A/G)CTTCT intron-variant
rs1000436850 -- 18,672,562(+) GTGTA(C/T)CCCCG intron-variant, nc-transcript-variant
rs1000678739 -- 18,667,001(+) TTTTT(-/C)TTTTT intron-variant, nc-transcript-variant
rs1000763966 -- 18,660,364(+) AAAAG(C/G)TCCCT utr-variant-3-prime
rs1000853660 -- 18,677,118(+) TGACA(A/G)GCATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF286B Gene

Variant ID Type Subtype PubMed ID
nsv962277 CNV duplication 23825009
nsv9504 CNV gain+loss 18304495
nsv833389 CNV gain 17160897
nsv827913 CNV gain 20364138
nsv523721 CNV gain 19592680
nsv499818 OTHER inversion 21111241
nsv1060744 CNV gain 25217958
nsv1057803 CNV loss 25217958
esv3640159 CNV gain 21293372
esv3640158 CNV loss 21293372
esv3572454 CNV gain 25503493
dgv564e214 CNV gain 21293372
dgv3111n100 CNV gain 25217958

Variation tolerance for ZNF286B Gene

Residual Variation Intolerance Score: 92.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 17.28; 98.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF286B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF286B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF286B Gene

Disorders for ZNF286B Gene

Relevant External Links for ZNF286B

Genetic Association Database (GAD)
ZNF286B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF286B

No disorders were found for ZNF286B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF286B Gene

Publications for ZNF286B Gene

  1. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 3 4 60
  2. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PMID: 17903294) Yang Q … O'Donnell CJ (BMC medical genetics 2007) 45 60
  3. Genome-wide association with diabetes-related traits in the Framingham Heart Study. (PMID: 17903298) Meigs JB … Dupuis J (BMC medical genetics 2007) 45 60
  4. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PMID: 17903299) Kathiresan S … Cupples LA (BMC medical genetics 2007) 45 60
  5. Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness. (PMID: 17903302) Levy D … Mitchell GF (BMC medical genetics 2007) 45 60

Products for ZNF286B Gene

Sources for ZNF286B Gene

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