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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF286B Gene

protein-coding   GIFtS: 32
GCID: GC17M018561

Zinc Finger Protein 286B

(Previous names: zinc finger protein 286-like, zinc finger 286C pseudogene)
(Previous symbols: ZNF286L, ZNF286C)
  Search for ZNF286B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 286B1 2     Zinc Finger Protein 5901 2
ZNF286C1 2 3     Zinc Finger Protein 286-Like1
ZNF286L1 2 3     ZNF5902
Zinc Finger 286C Pseudogene1 2     Putative Zinc Finger Protein 286B2

External Ids:    HGNC: 332411   Entrez Gene: 7292882   Ensembl: ENSG000002494597   UniProtKB: P0CG313   

Export aliases for ZNF286B gene to outside databases

Previous GC identifers: GC17U900825 GC17M018511


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF286B Gene: 
ZNF286B (zinc finger protein 286B) is a protein-coding gene. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZFP69.

UniProtKB/Swiss-Prot: Z286B_HUMAN, P0CG31
Function: May be involved in transcriptional regulation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010718.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF286B gene promoter:
         Spz1   Olf-1   Evi-1   MEF-2A   POU2F1   POU2F1a   SEF-1 (1)   STAT3   aMEF-2   MRF-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ZNF286B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF286B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p11.2   Ensembl cytogenetic band:  17p11.2   HGNC cytogenetic band: 17p11.2

ZNF286B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF286B gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M018561:  view genomic region     (about GC identifiers)

Start:
18,561,742 bp from pter      End:
18,585,575 bp from pter
Size:
23,834 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: Z286B_HUMAN, P0CG31 (See protein sequence)
Recommended Name: Putative zinc finger protein 286B  
Size: 522 amino acids; 59572 Da
Subcellular location: Nucleus (Probable)
Caution: Could be the product of a pseudogene

Explore the universe of human proteins at neXtProt for ZNF286B: NX_P0CG31

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P0CG31

  • ZNF286B Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins: NP_001138517.1  
    ENSEMBL proteins: 
     ENSP00000460210   ENSP00000462368   ENSP00000463300   ENSP00000460736   ENSP00000461413  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    ZNF286B for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry P0CG31

    ProtoNet protein and cluster: P0CG31

    UniProtKB/Swiss-Prot: Z286B_HUMAN, P0CG31
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 10 C2H2-type zinc fingers


    ZNF286B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: Z286B_HUMAN, P0CG31
    Function: May be involved in transcriptional regulation (By similarity)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF286B for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF286B

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF286B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF286B (Z286B)

    Search CenterWatch for drugs/clinical trials and news about ZNF286B / Z286B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for ZNF286B gene: 
    NM_001145045.1  

    Unigene Cluster for ZNF286B:

    Zinc finger protein 286B
    Hs.534279  [show with all ESTs]
    Unigene Representative Sequence: NM_001145045
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000285274 ENST00000580145 ENST00000583002 ENST00000443457 ENST00000442380
    ENST00000454745 ENST00000545289(uc010vyd.1)
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    hsa-miR-539 hsa-miR-526b hsa-miR-130a* hsa-miR-548o hsa-miR-23c hsa-miR-373* hsa-miR-513b hsa-miR-23b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    7 DOTS entries:

    DT.121012357  DT.92017894  DT.97835074  DT.95325248  DT.120974353  DT.120922656  DT.75137230 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF286B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZNF286B Expression
    About this image


    Genevestigator expression for ZNF286B

    SOURCE GeneReport for Unigene cluster: Hs.534279
        SABiosciences Custom PCR Arrays for ZNF286B
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF286B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
      --

    ENSEMBL Gene Tree for ZNF286B (if available)
    TreeFam Gene Tree for ZNF286B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF286B gene
    ZFP692  ENSG000001876072  ZNF5142  ZNF7132  ZFP69B2  ZNF286A2  ZNF82  ZNF3912  
    18/513 SIMAP similar genes for ZNF286B using alignment to 5 protein entries:     Z286B_HUMAN (see all proteins) (see all similar genes):
    ZNF286A    ZNF78L1    ZNF818P    kr-znf3    ZNF22    ZNF808
    ZFP41    ZNF24    ZFS-4    ZNF211    ZNF56    ZNF883
    ZSCAN22    DKFZp686M04222    HZF30    HZF36    ZNF662    ZNF787

    ZNF286B for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ZNF286B
    PGOHUM00000241229


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/293 SNPs in ZNF286B are shown (see all 293)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs20553331,2
    C--18561260(+) cagccG/Atgcat 1 -- ds50012Minor allele frequency- A:0.25WA NA 4
    rs1513264001,2
    --18561263(+) CCATGC/TATCAC 1 -- ds50010--------
    rs72129291,2
    C--18561264(+) CATGCA/GTCACC 1 -- ds50011Minor allele frequency- G:0.00NA 2
    rs1854977251,2
    --18562148(+) ATGGTC/TACAGT 1 -- ut310--------
    rs26493961,2
    C,H--18562532(+) TTTCTT/CTTCAC 1 -- ut315Minor allele frequency- C:0.00NS EA NA 408
    rs44520121,2
    C,F,H--18562691(+) ACCTAG/CTTTCT 1 -- ut3118Minor allele frequency- C:0.19NS EA NA WA CSA 1205
    rs44413301,2
    C,F,H--18562720(+) TTATCC/TGACTT 1 -- ut3125Minor allele frequency- T:0.19NS EA NA WA CSA 2479
    rs785675621,2
    C--18562755(+) GCCAAG/TAAAAT 1 -- ut310--------
    rs583214341,2
    C--18563169(+) ACTCAC/GTTCTG 1 -- ut310--------
    rs786227561,2
    C,F--18563305(+) GTCAAC/TTCCTG 1 -- ut311Minor allele frequency- T:0.50NA 4

    HapMap Linkage Disequilibrium report for ZNF286B (18561742 - 18585575 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ZNF286B:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833389CNV Gain17160897
    nsv523721CNV Gain19592680
    nsv827913CNV Gain20364138
    nsv907782CNV Gain21882294
    nsv9504CNV Gain+Loss18304495
    nsv499818OTHER Inversion21111241

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZNF286B for disorders           About MalaCards

    ZNF286B for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZNF286B

    Export disorders for ZNF286B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF286B gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF286B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)1, 2 Zody M.C.... Nusbaum C. (2006)
    2. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    3. Genome-wide association with diabetes-related traits in the Framingham Heart Study. (PubMed id 17903298)4 Meigs J.B....Dupuis J. (2007)
    4. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PubMed id 17903294)4 Yang Q....O'Donnell C.J. (2007)
    5. Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness. (PubMed id 17903302)4 Levy D....Mitchell G.F. (2007)
    6. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (2007)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 729288 HGNC: 33241 Ensembl:ENSG00000249459 euGenes: HUgn729288 ECgene: ZNF286B
    H-InvDB: ZNF286B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF286B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF286B gene:
    Search GeneIP for patents involving ZNF286B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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