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Aliases for ZNF286A Gene

Aliases for ZNF286A Gene

  • Zinc Finger Protein 286A 2 3 5
  • ZNF286 3 4
  • Zinc Finger Protein ZNF286 3
  • Zinc Finger Protein 286 2
  • KIAA1874 4

External Ids for ZNF286A Gene

Previous HGNC Symbols for ZNF286A Gene

  • ZNF286

Previous GeneCards Identifiers for ZNF286A Gene

  • GC17P015544
  • GC17P015602
  • GC17P015478
  • GC17P015701

Summaries for ZNF286A Gene

GeneCards Summary for ZNF286A Gene

ZNF286A (Zinc Finger Protein 286A) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ENSG00000255104.

UniProtKB/Swiss-Prot for ZNF286A Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF286A Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF286A Gene

Genomics for ZNF286A Gene

Regulatory Elements for ZNF286A Gene

Enhancers for ZNF286A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H016406 1.9 FANTOM5 Ensembl ENCODE dbSUPER 36.9 +708.1 708134 2 HDGF ZNF493 ZFP64 SIN3A FEZF1 YBX1 ZNF121 GLIS2 ZNF207 KLF7 PIGL PPIAP53 NCOR1 ENSG00000266538 TVP23C MPRIP-AS1 LOC644422 ZNF286A ENSG00000264729 MEIS3P1
GH17H016484 1.7 FANTOM5 Ensembl ENCODE dbSUPER 28.1 +788.6 788587 7 HDAC1 NFIB ZSCAN4 KLF17 TCF12 GLIS2 GATA2 SCRT2 EGR2 MCM3 ZNF286A ENSG00000266538 PPIAP53 PIGL MPRIP-AS1 MEIS3P1 ENSG00000265519 TVP23C CDRT4 TTC19
GH17H016652 1.1 ENCODE 30.9 +954.0 953990 1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 SP3 SP5 ZNF286A UPF3AP1 ZNF624 NEK4P2 ENSG00000264765 GC17P016634
GH17H016453 1.4 Ensembl ENCODE dbSUPER 18.9 +753.9 753924 0 HDGF ZSCAN4 ZNF2 RAD21 ZNF121 ZNF302 ZNF366 ZNF143 ZNF391 RUNX3 NCOR1 ENSG00000266538 ZNF286A MEIS3P1 LRRC75A ENSG00000265519 PIGL MPRIP LRRC75A-AS1 RPL13P12
GH17H016456 1 ENCODE dbSUPER 23.3 +757.4 757358 0 ZSCAN26 ZNF473 NFXL1 SALL2 RAD21 ZFHX2 ZNF366 ZNF600 EGR2 SP3 PIGL TVP23C MPRIP-AS1 ENSG00000266538 NCOR1 ZNF286A PPIAP53 LRRC75A-AS1 LOC644422 LRRC75A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF286A on UCSC Golden Path with GeneCards custom track

Promoters for ZNF286A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000091667 123 1401 HDGF PKNOX1 ATF1 MLX ARID4B SIN3A BRCA1 ETS1 ZNF121 GLIS2

Genomic Location for ZNF286A Gene

Chromosome:
17
Start:
15,699,577 bp from pter
End:
15,720,787 bp from pter
Size:
21,211 bases
Orientation:
Plus strand

Genomic View for ZNF286A Gene

Genes around ZNF286A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF286A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF286A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF286A Gene

Proteins for ZNF286A Gene

  • Protein details for ZNF286A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBT8-Z286A_HUMAN
    Recommended name:
    Zinc finger protein 286A
    Protein Accession:
    Q9HBT8
    Secondary Accessions:
    • B4DKF9
    • Q96JF3

    Protein attributes for ZNF286A Gene

    Size:
    521 amino acids
    Molecular mass:
    60175 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB47503.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF286A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF286A Gene

Post-translational modifications for ZNF286A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF286A Gene

Domains & Families for ZNF286A Gene

Gene Families for ZNF286A Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF286A Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF286A Gene

Graphical View of Domain Structure for InterPro Entry

Q9HBT8

UniProtKB/Swiss-Prot:

Z286A_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF286A: view

Function for ZNF286A Gene

Molecular function for ZNF286A Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF286A Gene

Gene Ontology (GO) - Molecular Function for ZNF286A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF286A: view

Phenotypes for ZNF286A Gene

genes like me logo Genes that share phenotypes with ZNF286A: view

Animal Model Products

CRISPR Products

miRNA for ZNF286A Gene

miRTarBase miRNAs that target ZNF286A

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF286A Gene

Localization for ZNF286A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF286A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF286A gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF286A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZNF286A: view

Pathways & Interactions for ZNF286A Gene

SuperPathways for ZNF286A Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF286A: view

Pathways by source for ZNF286A Gene

2 Reactome pathways for ZNF286A Gene

Gene Ontology (GO) - Biological Process for ZNF286A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF286A: view

No data available for SIGNOR curated interactions for ZNF286A Gene

Drugs & Compounds for ZNF286A Gene

No Compound Related Data Available

Transcripts for ZNF286A Gene

Unigene Clusters for ZNF286A Gene

Zinc finger protein 286A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF286A Gene

No ASD Table

Relevant External Links for ZNF286A Gene

GeneLoc Exon Structure for
ZNF286A
ECgene alternative splicing isoforms for
ZNF286A

Expression for ZNF286A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF286A Gene

Protein differential expression in normal tissues from HIPED for ZNF286A Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF286A Gene



Protein tissue co-expression partners for ZNF286A Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF286A Gene:

ZNF286A

SOURCE GeneReport for Unigene cluster for ZNF286A Gene:

Hs.585799

Evidence on tissue expression from TISSUES for ZNF286A Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with ZNF286A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF286A Gene

Orthologs for ZNF286A Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF286A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF286A 33 34
  • 99.55 (n)
dog
(Canis familiaris)
Mammalia ZNF286A 33
  • 91.54 (n)
-- 34
  • 90 (a)
OneToMany
cow
(Bos Taurus)
Mammalia ZNF286A 33 34
  • 85.45 (n)
mouse
(Mus musculus)
Mammalia Zfp286 33 16 34
  • 83.24 (n)
rat
(Rattus norvegicus)
Mammalia Zfp286a 33
  • 83.17 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 68 (a)
OneToMany
Species where no ortholog for ZNF286A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF286A Gene

ENSEMBL:
Gene Tree for ZNF286A (if available)
TreeFam:
Gene Tree for ZNF286A (if available)

Paralogs for ZNF286A Gene

genes like me logo Genes that share paralogs with ZNF286A: view

Variants for ZNF286A Gene

Sequence variations from dbSNP and Humsavar for ZNF286A Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000038013 -- 15,701,498(+) CTCCT(A/G)TGCTC intron-variant
rs1000202880 -- 15,711,864(+) GCCCC(-/G)CCCCC intron-variant
rs1000550436 -- 15,713,050(+) TTACT(A/G)TACTA intron-variant
rs1000723997 -- 15,718,186(+) TGCCT(C/T)GGCCT utr-variant-3-prime
rs1000819103 -- 15,701,098(+) TTTAA(A/G)TCTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF286A Gene

Variant ID Type Subtype PubMed ID
dgv3107n100 CNV gain 25217958
nsv1132447 CNV duplication 24896259
nsv457695 CNV gain 19166990
nsv515999 CNV loss 19592680
nsv518620 CNV loss 19592680
nsv520426 CNV loss 19592680
nsv522564 CNV loss 19592680
nsv574462 CNV gain 21841781
nsv827899 CNV gain 20364138
nsv962262 CNV duplication 23825009

Variation tolerance for ZNF286A Gene

Residual Variation Intolerance Score: 85.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.33; 53.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF286A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF286A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF286A Gene

Disorders for ZNF286A Gene

Relevant External Links for ZNF286A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF286A

No disorders were found for ZNF286A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF286A Gene

Publications for ZNF286A Gene

  1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 2 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D … Nagase T (DNA research : an international journal for rapid publication of reports on genes and genomes 2002) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60

Products for ZNF286A Gene

Sources for ZNF286A Gene

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