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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ZNF286A Gene

protein-coding GIFtS: 45
GCID: GC17P015602

zinc finger protein 286A

(Previous name: zinc finger protein 286 )
(Previous symbol: ZNF286)

Search for ZNF286A
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Zinc Finger Protein 286A¹ ²
ZNF286¹ ² ³
Zinc Finger Protein 286¹ ²
KIAA1874¹ ³
Zinc Finger Protein ZNF286²

External Ids:	HGNC: 13501¹	Entrez Gene: 57335²	Ensembl: ENSG00000187607⁷	UniProtKB: Q9HBT8³

Export aliases for ZNF286A gene to outside databases

Previous GC identifers: GC17P015544 GC17P015478

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: Z286A_HUMAN, Q9HBT8

Function: May be involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010718.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ZNF286A gene promoter:
RREB-1 Olf-1 FOXL1 Evi-1 POU2F1 POU2F1a SEF-1 (1) STAT3 PPAR-gamma2 MRF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZNF286A promoter sequence

Search SABiosciences Chromatin IP Primers for ZNF286A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF286A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p11.2 Ensembl cytogenetic band: 17p12 HGNC cytogenetic band: 17p11.2

ZNF286A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF286A gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P015602: view genomic region (about GC identifiers)

Start:	15,602,891 bp from pter	End:	15,640,874 bp from pter
Size:	37,984 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: Z286A_HUMAN, Q9HBT8 (See protein sequence)

Recommended Name: Zinc finger protein 286A

Size: 521 amino acids; 60175 Da

Subcellular location: Nucleus (Probable)

Sequence caution: Sequence=BAB47503.2; Type=Erroneous initiation;

Secondary accessions: Q96JF3

Explore the universe of human proteins at neXtProt for ZNF286A: NX_Q9HBT8

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9HBT8

ZNF286A Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001124314.1 NP_065703.1

ENSEMBL proteins:

ENSP00000462182 ENSP00000464063 ENSP00000461982 ENSP00000379231 ENSP00000463915

ENSP00000467718 ENSP00000462509 ENSP00000462679 ENSP00000461939 ENSP00000464218

ENSP00000379230 ENSP00000467116 ENSP00000466154 ENSP00000397163

Reactome Protein details: Q9HBT8
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	Uscn Proteins for ZNF286A

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005634	nucleus	IEA	--

ZNF286A for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZNF286A for domains About GeneDecksing

4 InterPro domains/families:

IPR015880 Znf_C2H2-like

IPR001909 Krueppel-associated_box

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q9HBT8

ProtoNet protein and cluster: Q9HBT8

1 Blocks protein family: IPB001909 KRAB box

UniProtKB/Swiss-Prot: Z286A_HUMAN, Q9HBT8

Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family

Similarity: Contains 10 C2H2-type zinc fingers

Similarity: Contains 1 KRAB domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: Z286A_HUMAN, Q9HBT8

Function: May be involved in transcriptional regulation

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		hsa-miR-181c hsa-miR-3692 hsa-miR-373* hsa-miR-1323 hsa-miR-23a hsa-miR-24 hsa-miR-412 hsa-miR-181b

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Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	--	--
GO:0003677	DNA binding	IEA	--
GO:0008270	zinc ion binding	IEA	--

ZNF286A for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Generic Transcription Pathway

Generic Transcription Pathway

1.00

Gene Expression

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

2 Reactome Pathways for ZNF286A

	Generic Transcription Pathway
	Gene Expression

ZNF286A for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZNF286A

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

ZNF286A for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZNF286A
Search CenterWatch for drugs/clinical trials and news about ZNF286A / Z286A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ZNF286A gene (2 alternative transcripts):

NM_001130842.1 NM_020652.2

Unigene Clusters for ZNF286A:

Zinc finger protein 286A

Hs.585799 [show with all ESTs], Hs.659318 [show with all ESTs]

Unigene Representative Sequences: NM_020652, BC025260

18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):

ENST00000585207 ENST00000582094 ENST00000580259 ENST00000583566 ENST00000472486

ENST00000395894 ENST00000579516 ENST00000581529 ENST00000579694 ENST00000580393

ENST00000585194 ENST00000583031 ENST00000464847(uc002gpa.3) ENST00000578258

ENST00000395893 ENST00000583347 ENST00000481540 ENST00000580136

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZNF286A
		8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNF286A (see all 23):
		hsa-miR-181c hsa-miR-3692 hsa-miR-373* hsa-miR-1323 hsa-miR-23a hsa-miR-24 hsa-miR-412 hsa-miR-181b

		SwitchGear 3'UTR luciferase reporter plasmid: ZNF286A 3' UTR sequence

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Additional cDNA sequence:

AK092259.1 BC015730.1 BC025260.1

14 DOTS entries:

DT.97835074 DT.120974357 DT.75184938 DT.121012357 DT.306228 DT.100738707 DT.97861735 DT.100649470

DT.120922656 DT.120974353 DT.70104658 DT.75142176 DT.95325248 DT.442696

24/117 AceView cDNA sequences (see all 117):

W73793 NM_020652 BQ232419 AF217226 AA706493 CR614025 AA766753 W73591

W96146 AF086305 AI192273 AK055651 BU621818 AW149625 BC047400 AW594050

AA129501 AI347331 BP378011 CB113420 BM700900 BM968434 AI631546 AA064977

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZNF286A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATCTTGGAA

About this image
See ZNF286A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF286A

SOURCE GeneReport for Unigene clusters: Hs.585799 Hs.659318

SABiosciences Custom PCR Arrays for ZNF286A

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

--

ENSEMBL Gene Tree for ZNF286A (if available)
TreeFam Gene Tree for ZNF286A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ZNF286A gene

ZNF713² ZFP69B² ZFP69² ZNF79² ZNF286B² ZNF391² ZNF514²

18/542 SIMAP similar genes for ZNF286A using alignment to 13 protein entries: Z286A_HUMAN (see all proteins) (see all similar genes):

ZNF286B ZNF78L1 ZNF818P kr-znf3 ZNF22 ZFP41

ZNF883 DKFZp666C237 ZFS-4 DKFZp686M04222 HZF30 HZF36

ZKSCAN1 ZNF24 ZNF787 ZNF826P ZSCAN22 zf30

ZNF286A for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs9909115^1,2	C,	--	15600897(+)	`TCACCA/GTAATA`	2	--	us2k¹		2		WA NA	4
rs188339206^1,2		--	15600931(+)	`TTTGAC/TTCTCT`	2	--	us2k¹		0	--	--	--	--
rs181829397^1,2		--	15600943(+)	`TCAATA/CATTTC`	2	--	us2k¹		0	--	--	--	--
rs138750054^1,2		--	15600949(+)	`ATTTCA/TATATG`	2	--	us2k¹		0	--	--	--	--
rs186440320^1,2		--	15600972(+)	`TTTTAG/TTTTTC`	2	--	us2k¹		0	--	--	--	--
rs188899577^1,2		--	15601099(+)	`CTTTTC/TCTCCC`	2	--	us2k¹		0	--	--	--	--
rs181790888^1,2		--	15601244(+)	`AGTTTC/TGTTGT`	2	--	us2k¹		0	--	--	--	--
rs144246068^1,2		--	15601301(+)	`TTTATC/TATTCT`	2	--	us2k¹		0	--	--	--	--
rs2601935^1,2	C,F	--	15601472(+)	`ATCCTG/CTTTTA`	2	--	us2k¹		3		WA NA CSA	6
rs8074851^1,2	C,F,A,H	--	15601532(+)	`ATACTT/CAGTGG`	2	--	us2k¹		9		NS EA NA WA CSA	428

HapMap Linkage Disequilibrium report for ZNF286A (15602891 - 15640874 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ZNF286A
1 CNV: 49824

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF286A

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZNF286A gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF286A)

Utopia: connect your pdf to the dynamic
world of online information

Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)^{1, 2, 3} Nagase T.... Ohara O. (2001)
Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)^{1, 2} Nakajima D.... Nagase T. (2002)
Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)¹ Suzuki Y.... Sugano S. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)¹ Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )² Aoki H.... Hino O. (2000)
Isolation of novel genes from the CMT1A duplication/HNPP deletion critical region in 17p11.2-p12. (PubMed id 9027492)¹ Murakami T....Lupski J.R. (1997)
Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)¹ Bonaldo M.F.... Soares M.B. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 57335	HGNC: 13501	AceView: ZNF286	Ensembl:ENSG00000187607	euGenes: HUgn57335
ECgene: ZNF286A	H-InvDB: ZNF286A

(According to HUGE)
About This Section

HUGE: KIAA1874

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ZNF286A	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZNF286A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ZNF286A gene:
Search GeneIP for patents involving ZNF286A

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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ZNF286A Gene

zinc finger protein 286A

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ZNF286A Gene

zinc finger protein 286A

Aliasesfor ZNF286A gene

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Protein Domains /Familiesfor ZNF286A gene

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for ZNF286A gene

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for ZNF286A gene

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for ZNF286A gene

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