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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF286A Gene

protein-coding   GIFtS: 44
GCID: GC17P015602

Zinc Finger Protein 286A

(Previous name: zinc finger protein 286)
(Previous symbol: ZNF286)
  Search for ZNF286A
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 286A1 2
ZNF2861 2 3
Zinc Finger Protein 2861 2
Zinc Finger Protein ZNF2862
KIAA18743

External Ids:    HGNC: 135011   Entrez Gene: 573352   Ensembl: ENSG000002551047   UniProtKB: Q9HBT83   

Export aliases for ZNF286A gene to outside databases

Previous GC identifers: GC17P015544 GC17P015478


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF286A Gene: 
ZNF286A (zinc finger protein 286A) is a protein-coding gene. Among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZFP69.

UniProtKB/Swiss-Prot: Z286A_HUMAN, Q9HBT8
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010718.16  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF286A gene promoter:
         RREB-1   Olf-1   FOXL1   Evi-1   POU2F1   POU2F1a   SEF-1 (1)   STAT3   PPAR-gamma2   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF286A promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF286A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF286A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p11.2   Ensembl cytogenetic band:  17p12   HGNC cytogenetic band: 17p11.2

ZNF286A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF286A gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P015602:  view genomic region     (about GC identifiers)

Start:
15,602,891 bp from pter      End:
15,648,092 bp from pter
Size:
45,202 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: Z286A_HUMAN, Q9HBT8 (See protein sequence)
Recommended Name: Zinc finger protein 286A  
Size: 521 amino acids; 60175 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=BAB47503.2; Type=Erroneous initiation;
Secondary accessions: Q96JF3

Explore the universe of human proteins at neXtProt for ZNF286A: NX_Q9HBT8

Explore proteomics data for ZNF286A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9HBT8

  • ZNF286A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF286A Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001124314.1  NP_065703.1  

    ENSEMBL proteins: 
     ENSP00000408168   ENSP00000458062  
    Reactome Protein details: Q9HBT8
    Human Recombinant Protein Products for ZNF286A: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF286A for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9HBT8

    ProtoNet protein and cluster: Q9HBT8

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: Z286A_HUMAN, Q9HBT8
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 10 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF286A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: Z286A_HUMAN, Q9HBT8
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF286A for ontologies           About GeneDecksing


    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidZNF286A 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF286A About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF286A
        Generic Transcription Pathway
    Gene Expression



    ZNF286A for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF286A

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF286A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF286A (Z286A)

    Search CenterWatch for drugs/clinical trials and news about ZNF286A / Z286A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF286A gene (2 alternative transcripts): 
    NM_001130842.1  NM_020652.2  

    Unigene Clusters for ZNF286A:

    Zinc finger protein 286A
    Hs.585799  [show with all ESTs], Hs.659318  [show with all ESTs]
    Unigene Representative Sequences: NM_020652, BC025260
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000412988 ENST00000585171 ENST00000583675 ENST00000413242(uc010cov.3)

    miRNA
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    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNF286A (see all 23):
    hsa-miR-181c hsa-miR-3692 hsa-miR-373* hsa-miR-1323 hsa-miR-23a hsa-miR-24 hsa-miR-412 hsa-miR-181b
    SwitchGear 3'UTR luciferase reporter plasmidZNF286A 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    Clone
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                         Customized lentivirus expression plasmids for stable overexpression of ZNF286A 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF286A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF286A

    Additional mRNA sequence: 

    AK021478.1 AK092259.1 BC015730.1 BC025260.1 

    14 DOTS entries:

    DT.97835074  DT.120974357  DT.75184938  DT.121012357  DT.306228  DT.100738707  DT.97861735  DT.100649470 
    DT.120922656  DT.120974353  DT.70104658  DT.75142176  DT.95325248  DT.442696 

    24/117 AceView cDNA sequences (see all 117):

    AA766753 CR614025 W73591 W96146 AA706493 NM_020652 AI192273 BQ232419 
    AF217226 AF086305 AK055651 W73793 BM968434 AA026046 BC047400 BU740137 
    BU753772 AI970232 BE395689 AA991672 AA758206 AK021478 CD676640 AW304755 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF286A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATCTTGGAA
    ZNF286A Expression
    About this image


    See ZNF286A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF286A

    SOURCE GeneReport for Unigene clusters: Hs.585799 Hs.659318
        SABiosciences Custom PCR Arrays for ZNF286A
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for ZNF286A gene from 1/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp2861 , 5 zinc finger protein 2861, 5 83.24(n)1
    82.46(a)1
      11 (38.68 cM)5
    1926511  NM_138949.31  NP_620399.31 
     627533775 


    ENSEMBL Gene Tree for ZNF286A (if available)
    TreeFam Gene Tree for ZNF286A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF286A gene
    ZFP692  ENSG000001876072  ZNF286B2  ZNF5142  ZFP69B2  ZNF7132  ZNF82  ZNF3912  
    18/548 SIMAP similar genes for ZNF286A using alignment to 13 protein entries:     Z286A_HUMAN (see all proteins) (see all similar genes):
    ZNF286B    ZNF78L1    ZNF818P    kr-znf3    ZNF22    ZFP41
    ZNF883    DKFZp666C237    ZFS-4    DKFZp686M04222    HZF30    HZF36
    ZKSCAN1    ZNF24    ZNF787    ZNF826P    ZSCAN22    zf30

    ZNF286A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/463 SNPs in ZNF286A are shown (see all 463)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs99091151,2
    C--15600897(+) TCACCA/GTAATA 2 -- us2k12Minor allele frequency- G:0.00WA NA 4
    rs1883392061,2
    --15600931(+) TTTGAC/TTCTCT 2 -- us2k10--------
    rs1818293971,2
    --15600943(+) TCAATA/CATTTC 2 -- us2k10--------
    rs1387500541,2
    --15600949(+) ATTTCA/TATATG 2 -- us2k10--------
    rs1864403201,2
    --15600972(+) TTTTAG/TTTTTC 2 -- us2k10--------
    rs1888995771,2
    --15601099(+) CTTTTC/TCTCCC 2 -- us2k10--------
    rs1817908881,2
    --15601244(+) AGTTTC/TGTTGT 2 -- us2k10--------
    rs2020194971,2
    C--15601245(+) GTTTCA/GTTGTT 2 -- us2k10--------
    rs1442460681,2
    --15601301(+) TTTATC/TATTCT 2 -- us2k10--------
    rs26019351,2
    C,F--15601472(+) ATCCTG/CTTTTA 2 -- us2k13Minor allele frequency- C:0.50WA NA CSA 6

    HapMap Linkage Disequilibrium report for ZNF286A (15602891 - 15648092 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for ZNF286A:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv515999CNV Loss19592680
    nsv522564CNV Loss19592680
    nsv518620CNV Loss19592680
    nsv520426CNV Loss19592680
    nsv907705CNV Gain21882294
    nsv827899CNV Gain20364138
    nsv457695CNV Gain19166990

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF286A gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF286A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)1, 2, 3 Nagase T.... Ohara O. (2001)
    2. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
    3. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    6. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
    7. Isolation of novel genes from the CMT1A duplication/HNPP deletion critical region in 17p11.2-p12. (PubMed id 9027492)1 Murakami T....Lupski J.R. (1997)
    8. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57335 HGNC: 13501 AceView: ZNF286 Ensembl:ENSG00000255104 euGenes: HUgn57335
    ECgene: ZNF286A H-InvDB: ZNF286A

    (According to HUGE)
    About This Section
    HUGE: KIAA1874

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF286A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF286A gene:
    Search GeneIP for patents involving ZNF286A

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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
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