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Aliases for ZNF286A Gene

Aliases for ZNF286A Gene

  • Zinc Finger Protein 286A 2 3
  • ZNF286 3 4
  • Zinc Finger Protein ZNF286 3
  • Zinc Finger Protein 286 2
  • KIAA1874 4

External Ids for ZNF286A Gene

Previous HGNC Symbols for ZNF286A Gene

  • ZNF286

Previous GeneCards Identifiers for ZNF286A Gene

  • GC17P015544
  • GC17P015602
  • GC17P015478

Summaries for ZNF286A Gene

GeneCards Summary for ZNF286A Gene

ZNF286A (Zinc Finger Protein 286A) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF529.

UniProtKB/Swiss-Prot for ZNF286A Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF286A Gene

Genomics for ZNF286A Gene

Regulatory Elements for ZNF286A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF286A Gene

Chromosome:
17
Start:
15,699,577 bp from pter
End:
15,720,787 bp from pter
Size:
21,211 bases
Orientation:
Plus strand

Genomic View for ZNF286A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF286A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF286A Gene

Proteins for ZNF286A Gene

  • Protein details for ZNF286A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBT8-Z286A_HUMAN
    Recommended name:
    Zinc finger protein 286A
    Protein Accession:
    Q9HBT8
    Secondary Accessions:
    • B4DKF9
    • Q96JF3

    Protein attributes for ZNF286A Gene

    Size:
    521 amino acids
    Molecular mass:
    60175 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB47503.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF286A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF286A Gene

Proteomics data for ZNF286A Gene at MOPED

Post-translational modifications for ZNF286A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF286A Gene

Domains & Families for ZNF286A Gene

Gene Families for ZNF286A Gene

Protein Domains for ZNF286A Gene

Suggested Antigen Peptide Sequences for ZNF286A Gene

Graphical View of Domain Structure for InterPro Entry

Q9HBT8

UniProtKB/Swiss-Prot:

Z286A_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 10 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 10 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF286A: view

Function for ZNF286A Gene

Molecular function for ZNF286A Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF286A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF286A: view

Phenotypes for ZNF286A Gene

GenomeRNAi human phenotypes for ZNF286A:
genes like me logo Genes that share phenotypes with ZNF286A: view

Animal Model Products

CRISPR Products

miRNA for ZNF286A Gene

miRTarBase miRNAs that target ZNF286A

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF286A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF286A Gene

Localization for ZNF286A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF286A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF286A Gene COMPARTMENTS Subcellular localization image for ZNF286A gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for ZNF286A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF286A: view

Pathways & Interactions for ZNF286A Gene

SuperPathways for ZNF286A Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF286A: view

Pathways by source for ZNF286A Gene

2 Reactome pathways for ZNF286A Gene

Gene Ontology (GO) - Biological Process for ZNF286A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF286A: view

No data available for SIGNOR curated interactions for ZNF286A Gene

Drugs & Compounds for ZNF286A Gene

No Compound Related Data Available

Transcripts for ZNF286A Gene

Unigene Clusters for ZNF286A Gene

Zinc finger protein 286A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF286A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF286A Gene

No ASD Table

Relevant External Links for ZNF286A Gene

GeneLoc Exon Structure for
ZNF286A
ECgene alternative splicing isoforms for
ZNF286A

Expression for ZNF286A Gene

mRNA expression in normal human tissues for ZNF286A Gene

Protein differential expression in normal tissues from HIPED for ZNF286A Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF286A Gene



SOURCE GeneReport for Unigene cluster for ZNF286A Gene Hs.585799

genes like me logo Genes that share expression patterns with ZNF286A: view

Protein tissue co-expression partners for ZNF286A Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF286A Gene

Orthologs for ZNF286A Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF286A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF286A 35
  • 85.45 (n)
  • 87.69 (a)
ZNF286A 36
  • 88 (a)
OneToMany
dog
(Canis familiaris)
Mammalia ZNF286A 35
  • 91.54 (n)
  • 90 (a)
-- 36
  • 90 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Zfp286 35
  • 83.24 (n)
  • 82.46 (a)
Zfp286 16
Zfp286 36
  • 82 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia ZNF286A 35
  • 99.55 (n)
  • 99.42 (a)
ZNF286A 36
  • 99 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Zfp286a 35
  • 83.17 (n)
  • 83.24 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 68 (a)
OneToMany
Species with no ortholog for ZNF286A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF286A Gene

ENSEMBL:
Gene Tree for ZNF286A (if available)
TreeFam:
Gene Tree for ZNF286A (if available)

Paralogs for ZNF286A Gene

genes like me logo Genes that share paralogs with ZNF286A: view

Variants for ZNF286A Gene

Sequence variations from dbSNP and Humsavar for ZNF286A Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs13915 -- 15,720,506(-) TGATA(C/T)GAAGT utr-variant-3-prime
rs163371 -- 15,707,951(-) CAGGT(A/C/G/T)TCGAA intron-variant
rs163372 -- 15,711,508(-) CAGTG(A/T)TATTA intron-variant
rs163374 -- 15,700,268(-) CCTGG(A/C)CAGAC utr-variant-5-prime, reference, missense, intron-variant
rs163375 -- 15,704,069(-) AAAAA(A/T)AATAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF286A Gene

Variant ID Type Subtype PubMed ID
nsv457695 CNV Gain 19166990
nsv520426 CNV Loss 19592680
nsv518620 CNV Loss 19592680
nsv522564 CNV Loss 19592680
nsv515999 CNV Loss 19592680
nsv827899 CNV Gain 20364138
nsv907705 CNV Gain 21882294

Variation tolerance for ZNF286A Gene

Residual Variation Intolerance Score: 85.93% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.33; 53.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF286A Gene

HapMap Linkage Disequilibrium report
ZNF286A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF286A Gene

Disorders for ZNF286A Gene

Relevant External Links for ZNF286A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF286A
genes like me logo Genes that share disorders with ZNF286A: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF286A Gene

Publications for ZNF286A Gene

  1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 2 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 67
  4. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 67
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67

Products for ZNF286A Gene

Sources for ZNF286A Gene

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