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Aliases for ZNF285 Gene

Aliases for ZNF285 Gene

  • Zinc Finger Protein 285 2 3
  • Zinc Finger Protein 285A 2 3 4
  • ZNF285A 3 4

External Ids for ZNF285 Gene

Previous HGNC Symbols for ZNF285 Gene

  • ZNF285A

Previous GeneCards Identifiers for ZNF285 Gene

  • GC00U990660
  • GC19U900206
  • GC19M049578
  • GC19M044886
  • GC19M041321

Summaries for ZNF285 Gene

GeneCards Summary for ZNF285 Gene

ZNF285 (Zinc Finger Protein 285) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF155.

UniProtKB/Swiss-Prot for ZNF285 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF285 Gene

Genomics for ZNF285 Gene

Genomic Location for ZNF285 Gene

Chromosome:
19
Start:
44,382,298 bp from pter
End:
44,401,611 bp from pter
Size:
19,314 bases
Orientation:
Minus strand

Genomic View for ZNF285 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF285 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF285 Gene

No data available for Regulatory Elements for ZNF285 Gene

Proteins for ZNF285 Gene

  • Protein details for ZNF285 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96NJ3-ZN285_HUMAN
    Recommended name:
    Zinc finger protein 285
    Protein Accession:
    Q96NJ3
    Secondary Accessions:
    • Q17RJ3
    • Q6B0A8
    • Q6ISR5

    Protein attributes for ZNF285 Gene

    Size:
    590 amino acids
    Molecular mass:
    68261 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF285 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF285 Gene

Proteomics data for ZNF285 Gene at MOPED

Post-translational modifications for ZNF285 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF285 Gene

Domains & Families for ZNF285 Gene

Gene Families for ZNF285 Gene

Protein Domains for ZNF285 Gene

Suggested Antigen Peptide Sequences for ZNF285 Gene

Graphical View of Domain Structure for InterPro Entry

Q96NJ3

UniProtKB/Swiss-Prot:

ZN285_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 11 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 11 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF285: view

Function for ZNF285 Gene

Molecular function for ZNF285 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF285 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF285: view

Phenotypes for ZNF285 Gene

GenomeRNAi human phenotypes for ZNF285:
genes like me logo Genes that share phenotypes with ZNF285: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF285

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF285 Gene

Localization for ZNF285 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF285 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF285 Gene COMPARTMENTS Subcellular localization image for ZNF285 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for ZNF285 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF285: view

Pathways & Interactions for ZNF285 Gene

SuperPathways for ZNF285 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF285: view

Pathways by source for ZNF285 Gene

2 Reactome pathways for ZNF285 Gene

Interacting Proteins for ZNF285 Gene

Gene Ontology (GO) - Biological Process for ZNF285 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF285: view

No data available for SIGNOR curated interactions for ZNF285 Gene

Drugs & Compounds for ZNF285 Gene

No Compound Related Data Available

Transcripts for ZNF285 Gene

Unigene Clusters for ZNF285 Gene

Zinc finger protein 285:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF285

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF285 Gene

No ASD Table

Relevant External Links for ZNF285 Gene

GeneLoc Exon Structure for
ZNF285
ECgene alternative splicing isoforms for
ZNF285

Expression for ZNF285 Gene

mRNA expression in normal human tissues for ZNF285 Gene

SOURCE GeneReport for Unigene cluster for ZNF285 Gene Hs.709428

genes like me logo Genes that share expression patterns with ZNF285: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZNF285 Gene

Orthologs for ZNF285 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF285 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF285 35
  • 98.08 (n)
  • 97.12 (a)
ZNF285 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF285 36
  • 75 (a)
OneToOne
Species with no ortholog for ZNF285:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF285 Gene

ENSEMBL:
Gene Tree for ZNF285 (if available)
TreeFam:
Gene Tree for ZNF285 (if available)

Paralogs for ZNF285 Gene

(515) SIMAP similar genes for ZNF285 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZNF285: view

Variants for ZNF285 Gene

Sequence variations from dbSNP and Humsavar for ZNF285 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs494327 -- 44,388,834(+) CTGAT(A/G)GCTTC intron-variant
rs595552 -- 44,388,979(-) CAGGA(C/T)CATAT intron-variant
rs596016 -- 44,388,911(-) GCTCA(C/T)CATGT intron-variant
rs596135 -- 44,388,833(-) AAGCC(A/T)TCAGG intron-variant
rs892593 -- 44,401,116(+) CAGCC(C/G)AAGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF285 Gene

Variant ID Type Subtype PubMed ID
dgv3943n71 CNV Loss 21882294
nsv515911 CNV Loss 19592680
dgv3944n71 CNV Loss 21882294
nsv912113 CNV Loss 21882294
esv2663330 CNV Deletion 23128226
esv25060 CNV Loss 19812545
nsv9734 CNV Gain+Loss 18304495
dgv1106e1 CNV Complex 17122850
esv2421963 CNV Deletion 20811451
nsv442465 CNV CNV 18776908
nsv817849 CNV Loss 17921354

Variation tolerance for ZNF285 Gene

Residual Variation Intolerance Score: 98.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.62; 94.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF285 Gene

HapMap Linkage Disequilibrium report
ZNF285

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF285 Gene

Disorders for ZNF285 Gene

Relevant External Links for ZNF285

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF285
genes like me logo Genes that share disorders with ZNF285: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF285 Gene

Publications for ZNF285 Gene

  1. A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population. (PMID: 23049088) Meng W. … Malecaze F. (Invest. Ophthalmol. Vis. Sci. 2012) 67
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 67
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 67
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67

Products for ZNF285 Gene

Sources for ZNF285 Gene

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