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ZNF285 Gene

protein-coding   GIFtS: 40
GCID: GC19M044886

Zinc Finger Protein 285

(Previous name: zinc finger protein 285A)
(Previous symbol: ZNF285A)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 2851 2
Zinc Finger Protein 285A1 2 3
ZNF285A1 2 3

External Ids:    HGNC: 130791   Entrez Gene: 269742   Ensembl: ENSG000002675087   UniProtKB: Q96NJ33   

Export aliases for ZNF285 gene to outside databases

Previous GC identifers: GC00U990660 GC19U900206 GC19M049578 GC19M041321


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF285 Gene:
ZNF285 (zinc finger protein 285) is a protein-coding gene. Diseases associated with ZNF285 include myopia. An important paralog of this gene is ZNF229.

UniProtKB/Swiss-Prot: ZN285_HUMAN, Q96NJ3
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for ZNF285
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF285 promoter sequence
   Search Chromatin IP Primers for ZNF285

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF285


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Ensembl cytogenetic band:  19q13.31   HGNC cytogenetic band: 19q13.32

ZNF285 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF285 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M044886:  view genomic region     (about GC identifiers)

Start:
44,886,459 bp from pter      End:
44,905,777 bp from pter
Size:
19,319 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ZN285_HUMAN, Q96NJ3 (See protein sequence)
Recommended Name: Zinc finger protein 285  
Size: 590 amino acids; 68261 Da
Secondary accessions: Q17RJ3 Q6B0A8 Q6ISR5
Alternative splicing: 2 isoforms:  Q96NJ3-1   Q96NJ3-2   

Explore the universe of human proteins at neXtProt for ZNF285: NX_Q96NJ3

Explore proteomics data for ZNF285 at MOPED


See ZNF285 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_689567.3  
ENSEMBL proteins: 
 ENSP00000333595   ENSP00000439431   ENSP00000464788   ENSP00000468399   ENSP00000467795  
Reactome Protein details: Q96NJ3

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
ZNF: Zinc fingers, C2H2-type

4 InterPro protein domains:
 IPR001909 Krueppel-associated_box
 IPR015880 Znf_C2H2-like
 IPR013087 Znf_C2H2/integrase_DNA-bd
 IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q96NJ3

ProtoNet protein and cluster: Q96NJ3

1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

UniProtKB/Swiss-Prot: ZN285_HUMAN, Q96NJ3
Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
Similarity: Contains 11 C2H2-type zinc fingers
Similarity: Contains 1 KRAB domain


ZNF285 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: ZN285_HUMAN, Q96NJ3
Function: May be involved in transcriptional regulation

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003676nucleic acid binding ----
GO:0003677DNA binding IEA--
GO:0046872metal ion binding IEA--
     
ZNF285 for ontologies           About GeneDecksing


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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
ZN285_HUMAN, Q96NJ3: Nucleus (Probable)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus4

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005622intracellular ----
GO:0005634nucleus IEA--

ZNF285 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for ZNF285 About    
See pathways by source

SuperPathContained pathways About
1Gene Expression
Generic Transcription Pathway0.40
Gene Expression0.40

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 Reactome Pathway for ZNF285
    Generic Transcription Pathway



ZNF285 for pathways           About GeneDecksing

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF285
Interactions:

    Search GeneGlobe Interaction Network for ZNF285

Gene Ontology (GO): 2 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006351transcription, DNA-templated IEA--
GO:0006355regulation of transcription, DNA-templated IEA--

ZNF285 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for ZNF285 (ZN285)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for ZNF285 gene: 
NM_152354.4  

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000330997(uc010xxa.2 uc002ozd.4) ENST00000544719 ENST00000591679
ENST00000585868 ENST00000589738 ENST00000589885
miRNA
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1 qRT-PCR Assays for microRNA that regulate ZNF285:
hsa-miR-3667-3p
SwitchGear 3'UTR luciferase reporter plasmidZNF285 3' UTR sequence
Inhib. RNA
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Selected AceView cDNA sequences (see all 25):

BX282010 NM_152354 AA716578 AI208630 BC074824 AW513227 AW183184 BF343511 
BC074875 BM681972 BM729030 AL833447 BX643240 AA813778 BC069384 BQ215606 
AY166790 BX488656 AI208631 BM987858 AK055309 BF352512 AW812382 AI369486 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ZNF285 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TGAAAATTCA
ZNF285 Expression
About this image

ZNF285 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

ZNF285 Protein Expression
    Custom PCR Arrays for ZNF285
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of mammals.

Orthologs for ZNF285 gene from Selected species (see all 2)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
dog
(Canis familiaris)
Mammalia ZNF2856
zinc finger protein 285
75(a)
1 ↔ 1
1(110916106-110917629)


ENSEMBL Gene Tree for ZNF285 (if available)
TreeFam Gene Tree for ZNF285 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for ZNF285 gene
ZNF2292  ZNF2232  ZNF2302  ZNF1552  ZNF2272  ZNF2242  ZNF2342  ZNF2252  
ZNF2262  ZNF2142  ZNF2222  ZNF2842  ENSG000002671732  ZNF452  ZNF2352  ZNF2212  
ENSG000002670222  ZNF1122  ZNF2332  
Selected SIMAP similar genes for ZNF285 using alignment to 5 protein entries:     ZN285_HUMAN (see all proteins) (see all similar genes):
ZNF285A    ZNF806    ZFS-4    ZNF224    ZNF56    MGC12518
ZNF208    ZNF846    ZNF177    ZNF274    ZSCAN16    ZNF415
ZNF230    DKFZp686M04222    ZNF    ZNF235    ZNF226    ZNF589

ZNF285 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ZNF285 (see all 637)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1474801271,2
Cuntested144899532(+) CAGGAC/TACCAA 1 -- int10--------
rs772627401,2
C,F--44889353(+) TGTTGG/CTCACT 1 -- ds50012Minor allele frequency- C:0.50NA CSA 4
rs749191021,2
C--44889371(+) ATGTTG/AATTTT 1 -- ds50011Minor allele frequency- A:0.50NA 2
rs750522091,2
C--44889372(+) TGTTGG/ATTTTA 1 -- ds50011Minor allele frequency- A:0.50NA 2
rs2010684451,2
C--44889423(-) AAATTA/GACTAG 1 -- ds50010--------
rs1174750201,2
C,F--44889510(+) TCTTAC/TGTCGG 1 -- ds50011Minor allele frequency- T:0.03EA 120
rs1143282391,2
--44889550(+) ACAGCC/TATATC 1 -- ds50010--------
rs2004466401,2
C--44889608(+) CACTGA/GAGAAG 1 -- ds50010--------
rs1862889161,2
--44889637(+) AGATGG/TTTGCA 1 -- ds50010--------
rs27227571,2
C,F,A,H--44889660(+) GCCTTA/GAAGAT 1 -- ds500123Minor allele frequency- G:0.26NS EA NA WA CSA 2522

HapMap Linkage Disequilibrium report for ZNF285 (44886459 - 44905777 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for ZNF285 (see all 11):    About this table    
Variant IDTypeSubtypePubMed ID
esv2421963CNV Deletion20811451
esv2663330CNV Deletion23128226
nsv817849CNV Loss17921354
dgv3943n71CNV Loss21882294
nsv515911CNV Loss19592680
esv25060CNV Loss19812545
dgv3944n71CNV Loss21882294
nsv912113CNV Loss21882294
nsv9734CNV Gain+Loss18304495
nsv442465CNV CNV18776908

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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1 disease for ZNF285:    
About MalaCards
myopia


ZNF285 for disorders           About GeneDecksing


Export disorders for ZNF285 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for ZNF285 gene integrated from 10 sources:
(articles sorted by number of sources associating them with ZNF285)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  2. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
  3. A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population. (PubMed id 23049088)1 Meng W....Malecaze F. (amp 2012)
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  6. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)
  7. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. (PubMed id 12743021)1 Shannon M.... Stubbs L. (Genome Res. 2003)
  8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 26974 HGNC: 13079 AceView: ZNF285 Ensembl:ENSG00000267508 euGenes: HUgn26974
ECgene: ZNF285 H-InvDB: ZNF285

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ZNF285 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ZNF285 gene:
Search GeneIP for patents involving ZNF285

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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