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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF285 Gene

protein-coding   GIFtS: 44
GCID: GC19M044886

Zinc Finger Protein 285

(Previous name: zinc finger protein 285A)
(Previous symbol: ZNF285A)
  Search for ZNF285
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 2851 2
Zinc Finger Protein 285A1 2 3
ZNF285A1 2 3

External Ids:    HGNC: 130791   Entrez Gene: 269742   Ensembl: ENSG000002675087   UniProtKB: Q96NJ33   

Export aliases for ZNF285 gene to outside databases

Previous GC identifers: GC00U990660 GC19U900206 GC19M049578 GC19M041321


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF285 Gene: 
ZNF285 (zinc finger protein 285) is a protein-coding gene. Among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF229.

UniProtKB/Swiss-Prot: ZN285_HUMAN, Q96NJ3
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ZNF285
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF285 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF285

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF285


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Ensembl cytogenetic band:  19q13.31   HGNC cytogenetic band: 19q13.32

ZNF285 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF285 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M044886:  view genomic region     (about GC identifiers)

Start:
44,886,459 bp from pter      End:
44,905,777 bp from pter
Size:
19,319 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN285_HUMAN, Q96NJ3 (See protein sequence)
Recommended Name: Zinc finger protein 285  
Size: 590 amino acids; 68261 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: Q17RJ3 Q6B0A8 Q6ISR5
Alternative splicing: 2 isoforms:  Q96NJ3-1   Q96NJ3-2   

Explore the universe of human proteins at neXtProt for ZNF285: NX_Q96NJ3

Explore proteomics data for ZNF285 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96NJ3

  • ZNF285 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF285 Protein Expression
    REFSEQ proteins: NP_689567.3  
    ENSEMBL proteins: 
     ENSP00000333595   ENSP00000439431   ENSP00000464788   ENSP00000468399   ENSP00000467795  
    Reactome Protein details: Q96NJ3
    Human Recombinant Protein Products for ZNF285: 
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    Novus Biologicals ZNF285 Lysate
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZNF285 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF285 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q96NJ3

    ProtoNet protein and cluster: Q96NJ3

    1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: ZN285_HUMAN, Q96NJ3
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 11 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF285 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN285_HUMAN, Q96NJ3
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF285 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZNF285 
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    miRNA
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    hsa-miR-3667-3p
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    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF285


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF285 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF285
        Generic Transcription Pathway
    Gene Expression



    ZNF285 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF285

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF285 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF285 (ZN285)

    Search CenterWatch for drugs/clinical trials and news about ZNF285 / ZN285

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF285 gene: 
    NM_152354.3  

    Unigene Cluster for ZNF285:

    Zinc finger protein 285
    Hs.709428  [show with all ESTs]
    Unigene Representative Sequence: AL833447
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000330997(uc010xxa.2 uc002ozd.4) ENST00000544719 ENST00000591679
    ENST00000585868 ENST00000589738 ENST00000589885
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZNF285
    1 QIAGEN miScript miRNA Assays for microRNA that regulate ZNF285:
    hsa-miR-3667-3p
    SwitchGear 3'UTR luciferase reporter plasmidZNF285 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ZNF285
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF285
    Clone
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    OriGene clones in human, mouse for ZNF285 (see all 7)
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    GenScript: all cDNA clones in your preferred vector: ZNF285 (NM_152354)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZNF285
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF285
    Sirion Biotech Customized lentivirus for stable overexpression of ZNF285 
                         Customized lentivirus expression plasmids for stable overexpression of ZNF285 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ZNF285
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF285
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF285

    Additional mRNA sequence: 

    AK055309.1 AL833447.1 AY166790.1 BC069384.1 BC074824.2 BC074875.2 BC117300.1 BC117302.1 
    BC143984.1 

    3 DOTS entries:

    DT.400938  DT.121459491  DT.121459486 

    24/25 AceView cDNA sequences (see all 25):

    AA716578 NM_152354 BX282010 AI208630 AA813778 AW513227 BC069384 BM987858 
    BM729030 AI208631 BQ215606 BF343511 AW183184 AL833447 BC074824 BM681972 
    AY166790 BX643240 BC074875 BX488656 AK055309 BF352512 AW812382 AI369486 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF285 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAAAATTCA
    ZNF285 Expression
    About this image


    See ZNF285 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF285

    SOURCE GeneReport for Unigene cluster: Hs.709428
        SABiosciences Custom PCR Arrays for ZNF285
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF285

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ZNF285 gene from 4/5 species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia ZNF2851 zinc finger protein 285 83.53(n)
    77.08(a)
      100687813  XM_003432659.1  XP_003432707.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 4)
    --
    39(a)
    33(a)
    (see all 4)
    1 ↔ many
    possible ortholog
    (see all 4)
    GL343884.1(112712-114268)
    AAWZ02037965(878-9727)
    zebrafish
    (Danio rerio)
    Actinopterygii CT990567.26
    si:ch211-231i17.46
    (see all 9)
    si:ch211-231i17.4
    (see all 9)
    46(a)
    38(a)
    (see all 9)
    many ↔ many
    many ↔ many
    (see all 9)
    4(48926599-48927610)
    4(29133676-29138334)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG66546
    --
    18(a)
    1 → many
    3R(11036999-11039380)


    ENSEMBL Gene Tree for ZNF285 (if available)
    TreeFam Gene Tree for ZNF285 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF285 gene
    ZNF2292  ZNF2232  ZNF2302  ENSG000000623702  ZNF1552  ZNF2272  ZNF2242  ZNF2252  
    ZNF2262  ZNF2142  ZNF2222  ZNF2842  ENSG000002671732  ZNF452  ZNF2352  ZNF2212  
    ENSG000002670222  ZNF2332  
    18/513 SIMAP similar genes for ZNF285 using alignment to 5 protein entries:     ZN285_HUMAN (see all proteins) (see all similar genes):
    ZNF285A    ZNF806    ZFS-4    ZNF224    ZNF56    MGC12518
    ZNF208    ZNF846    ZNF274    ZSCAN16    ZNF415    ZNF230
    DKFZp686M04222    ZNF    ZNF235    ZNF226    ZNF589    ZNF433

    ZNF285 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/637 SNPs in ZNF285 are shown (see all 637)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1474801271,2
    Cuntested144899532(+) CAGGAC/TACCAA 1 -- int10--------
    rs772627401,2
    C,F--44889353(+) TGTTGG/CTCACT 1 -- ds50012Minor allele frequency- C:0.50NA CSA 4
    rs749191021,2
    C--44889371(+) ATGTTG/AATTTT 1 -- ds50011Minor allele frequency- A:0.50NA 2
    rs750522091,2
    C--44889372(+) TGTTGG/ATTTTA 1 -- ds50011Minor allele frequency- A:0.50NA 2
    rs2010684451,2
    C--44889423(-) AAATTA/GACTAG 1 -- ds50010--------
    rs1174750201,2
    C,F--44889510(+) TCTTAC/TGTCGG 1 -- ds50011Minor allele frequency- T:0.03EA 120
    rs1143282391,2
    --44889550(+) ACAGCC/TATATC 1 -- ds50010--------
    rs2004466401,2
    C--44889608(+) CACTGA/GAGAAG 1 -- ds50010--------
    rs1862889161,2
    --44889637(+) AGATGG/TTTGCA 1 -- ds50010--------
    rs27227571,2
    C,F,A,H--44889660(+) GCCTTA/GAAGAT 1 -- ds500123Minor allele frequency- G:0.26NS EA NA WA CSA 2522

    HapMap Linkage Disequilibrium report for ZNF285 (44886459 - 44905777 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/11 variations for ZNF285 (see all 11):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2421963CNV Deletion20811451
    esv2663330CNV Deletion23128226
    nsv817849CNV Loss17921354
    dgv3943n71CNV Loss21882294
    nsv515911CNV Loss19592680
    esv25060CNV Loss19812545
    dgv3944n71CNV Loss21882294
    nsv912113CNV Loss21882294
    nsv9734CNV Gain+Loss18304495
    nsv442465CNV CNV18776908

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF285 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF285)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in t he French Population. (PubMed id 23049088)1 Meng W....Malecaze F. (2012)
    3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    4. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    6. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. (PubMed id 12743021)1 Shannon M.... Stubbs L. (2003)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 26974 HGNC: 13079 AceView: ZNF285 Ensembl:ENSG00000267508 euGenes: HUgn26974
    ECgene: ZNF285 H-InvDB: ZNF285

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF285 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF285 gene:
    Search GeneIP for patents involving ZNF285

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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