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Aliases for ZNF284 Gene

Aliases for ZNF284 Gene

  • Zinc Finger Protein 284 2 3 5
  • ZNF284L 3 4

External Ids for ZNF284 Gene

Previous GeneCards Identifiers for ZNF284 Gene

  • GC00U990661
  • GC19P049252
  • GC19P049268
  • GC19U900427
  • GC19P044578
  • GC19P041008
  • GC19P044580

Summaries for ZNF284 Gene

GeneCards Summary for ZNF284 Gene

ZNF284 (Zinc Finger Protein 284) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF224.

UniProtKB/Swiss-Prot for ZNF284 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF284 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF284 Gene

Genomics for ZNF284 Gene

Regulatory Elements for ZNF284 Gene

Enhancers for ZNF284 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H043773 2 FANTOM5 Ensembl ENCODE dbSUPER 139.6 -292.2 -292243 12.4 YBX1 ZNF416 ZNF143 SP3 ZC3H11A ZFP41 MEF2D ZNF610 ZNF585B GLIS1 ZNF180 ZNF45 ZNF225 ZNF227 ZNF284 ZNF223 ZNF224 ZNF283 ZNF235 ZNF576
GH19H044844 1.8 FANTOM5 ENCODE dbSUPER 81 +775.9 775871 7.3 YBX1 DMAP1 YY1 ZNF416 ZNF143 SP3 MCM3 ZNF610 GLIS1 RCOR2 ZNF180 ZNF45 CLASRP ZNF224 ZNF225 ZNF234 ZNF284 FBXO46 ENSG00000269148 LOC100505715
GH19H044259 1.1 ENCODE 112.7 +187.9 187889 1.4 HDGF PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 YBX1 ZNF2 ZBTB7B ZNF45 ZNF180 ZNF224 ZNF225 ZNF284 ZNF234 CLASRP ZNF227 ZNF235 XRCC1
GH19H043798 1.3 ENCODE dbSUPER 93.9 -273.1 -273127 1.6 ZNF133 ZNF2 ZNF121 GLIS2 ZNF416 KLF7 ZNF548 SP3 YY2 REST ZNF180 ZNF45 ZNF225 ZNF224 ZNF234 ZNF284 ZNF223 ZNF227 ZNF226 ZNF283
GH19H044740 2.1 FANTOM5 Ensembl ENCODE dbSUPER 56.2 +677.9 677874 19.4 YBX1 FEZF1 YY1 ZNF143 ZNF548 SP3 ZC3H11A MEF2D ZNF610 GLIS1 ZNF45 ZNF224 ZNF155 ZNF180 ZNF284 ZNF225 ZNF234 CLASRP ZNF235 ZNF283
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF284 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF284 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000110024 157 1800 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 SP3

Genomic Locations for ZNF284 Gene

Genomic Locations for ZNF284 Gene
17,470 bases
Plus strand

Genomic View for ZNF284 Gene

Genes around ZNF284 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF284 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF284 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF284 Gene

Proteins for ZNF284 Gene

  • Protein details for ZNF284 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 284
    Protein Accession:
    Secondary Accessions:
    • Q86WM1

    Protein attributes for ZNF284 Gene

    593 amino acids
    Molecular mass:
    69019 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF284 Gene

Post-translational modifications for ZNF284 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF284 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF284 Gene

Domains & Families for ZNF284 Gene

Gene Families for ZNF284 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF284 Gene

Suggested Antigen Peptide Sequences for ZNF284 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF284: view

Function for ZNF284 Gene

Molecular function for ZNF284 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF284 Gene

Gene Ontology (GO) - Molecular Function for ZNF284 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IBA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF284: view

Phenotypes for ZNF284 Gene

genes like me logo Genes that share phenotypes with ZNF284: view

miRNA for ZNF284 Gene

miRTarBase miRNAs that target ZNF284

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF284 Gene

Localization for ZNF284 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF284 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF284 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF284 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with ZNF284: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF284 Gene

Pathways & Interactions for ZNF284 Gene

SuperPathways for ZNF284 Gene

No Data Available

Interacting Proteins for ZNF284 Gene

Gene Ontology (GO) - Biological Process for ZNF284 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF284: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF284 Gene

Drugs & Compounds for ZNF284 Gene

No Compound Related Data Available

Transcripts for ZNF284 Gene

mRNA/cDNA for ZNF284 Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF284 Gene

Zinc finger protein 284:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF284 Gene

No ASD Table

Relevant External Links for ZNF284 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF284 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF284 Gene

Protein differential expression in normal tissues from HIPED for ZNF284 Gene

This gene is overexpressed in Tlymphocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF284 Gene

Protein tissue co-expression partners for ZNF284 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF284 Gene:


SOURCE GeneReport for Unigene cluster for ZNF284 Gene:


mRNA Expression by UniProt/SwissProt for ZNF284 Gene:

Tissue specificity: Expressed in lung, liver, pancreas and thymus. Lower expression in heart, placenta, spleen, prostate, ovary, small intestine and colon. No expression seen in brain, skeletal muscle, kidney, testis and peripheral blood leukocyte.

Evidence on tissue expression from TISSUES for ZNF284 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZNF284: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF284 Gene

Orthologs for ZNF284 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for ZNF284 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF284 33 34
  • 99.46 (n)
Species where no ortholog for ZNF284 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF284 Gene

Gene Tree for ZNF284 (if available)
Gene Tree for ZNF284 (if available)

Paralogs for ZNF284 Gene

(390) SIMAP similar genes for ZNF284 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZNF284: view

Variants for ZNF284 Gene

Sequence variations from dbSNP and Humsavar for ZNF284 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000180108 -- 44,077,932(+) CTCCT(C/T)AGGTG intron-variant
rs1000290482 -- 44,071,366(+) CTCTC(C/T)CCCTA upstream-variant-2KB
rs1000326383 -- 44,071,348(+) CTAAG(A/C)CTGTG upstream-variant-2KB
rs1000585405 -- 44,071,092(+) AAGTT(C/T)GCGTT upstream-variant-2KB
rs1000765663 -- 44,088,845(+) TGAGA(C/T)AGTCT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF284 Gene

Variant ID Type Subtype PubMed ID
nsv978827 CNV duplication 23825009
nsv833840 CNV gain 17160897
esv3556442 CNV deletion 23714750

Variation tolerance for ZNF284 Gene

Residual Variation Intolerance Score: 79.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.53; 92.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF284 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF284 Gene

Disorders for ZNF284 Gene

Relevant External Links for ZNF284

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF284 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF284 Gene

Publications for ZNF284 Gene

  1. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. (PMID: 12743021) Shannon M … Stubbs L (Genome research 2003) 2 3 4 60
  2. Cloning and characterization of a novel KRAB-domain-containing zinc finger gene (ZNF284L). (PMID: 16817023) Yin G … Mao Y (Molecular biology reports 2006) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for ZNF284 Gene

Sources for ZNF284 Gene

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