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Aliases for ZNF284 Gene

Aliases for ZNF284 Gene

  • Zinc Finger Protein 284 2 3 5
  • ZNF284L 3 4

External Ids for ZNF284 Gene

Previous GeneCards Identifiers for ZNF284 Gene

  • GC00U990661
  • GC19P049252
  • GC19P049268
  • GC19U900427
  • GC19P044578
  • GC19P041008
  • GC19P044580

Summaries for ZNF284 Gene

GeneCards Summary for ZNF284 Gene

ZNF284 (Zinc Finger Protein 284) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF229.

UniProtKB/Swiss-Prot for ZNF284 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF284 Gene

Genomics for ZNF284 Gene

Regulatory Elements for ZNF284 Gene

Promoters for ZNF284 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF284 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF284 Gene

Chromosome:
19
Start:
44,072,144 bp from pter
End:
44,089,613 bp from pter
Size:
17,470 bases
Orientation:
Plus strand

Genomic View for ZNF284 Gene

Genes around ZNF284 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF284 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF284 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF284 Gene

Proteins for ZNF284 Gene

  • Protein details for ZNF284 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2VY69-ZN284_HUMAN
    Recommended name:
    Zinc finger protein 284
    Protein Accession:
    Q2VY69
    Secondary Accessions:
    • Q86WM1

    Protein attributes for ZNF284 Gene

    Size:
    593 amino acids
    Molecular mass:
    69019 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF284 Gene

Proteomics data for ZNF284 Gene at MOPED

Post-translational modifications for ZNF284 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF284 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF284 Gene

Domains & Families for ZNF284 Gene

Gene Families for ZNF284 Gene

Protein Domains for ZNF284 Gene

Suggested Antigen Peptide Sequences for ZNF284 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q2VY69

UniProtKB/Swiss-Prot:

ZN284_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 15 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 15 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF284: view

Function for ZNF284 Gene

Molecular function for ZNF284 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes for ZNF284 Gene

genes like me logo Genes that share phenotypes with ZNF284: view

Animal Model Products

CRISPR Products

miRNA for ZNF284 Gene

miRTarBase miRNAs that target ZNF284

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF284 Gene

Localization for ZNF284 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF284 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF284 Gene COMPARTMENTS Subcellular localization image for ZNF284 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF284 Gene

Pathways & Interactions for ZNF284 Gene

SuperPathways for ZNF284 Gene

No Data Available

Interacting Proteins for ZNF284 Gene

Gene Ontology (GO) - Biological Process for ZNF284 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF284: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF284 Gene

Drugs & Compounds for ZNF284 Gene

No Compound Related Data Available

Transcripts for ZNF284 Gene

mRNA/cDNA for ZNF284 Gene

(5) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF284 Gene

Zinc finger protein 284:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF284 Gene

No ASD Table

Relevant External Links for ZNF284 Gene

GeneLoc Exon Structure for
ZNF284
ECgene alternative splicing isoforms for
ZNF284

Expression for ZNF284 Gene

mRNA expression in normal human tissues for ZNF284 Gene

Protein differential expression in normal tissues from HIPED for ZNF284 Gene

This gene is overexpressed in Tlymphocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF284 Gene



SOURCE GeneReport for Unigene cluster for ZNF284 Gene Hs.445395

mRNA Expression by UniProt/SwissProt for ZNF284 Gene

Q2VY69-ZN284_HUMAN
Tissue specificity: Expressed in lung, liver, pancreas and thymus. Lower expression in heart, placenta, spleen, prostate, ovary, small intestine and colon. No expression seen in brain, skeletal muscle, kidney, testis and peripheral blood leukocyte.
genes like me logo Genes that share expression patterns with ZNF284: view

Protein tissue co-expression partners for ZNF284 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZNF284 Gene

Orthologs for ZNF284 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for ZNF284 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF284 35
  • 99.46 (n)
  • 99.28 (a)
ZNF284 36
  • 99 (a)
OneToOne
Species with no ortholog for ZNF284:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF284 Gene

ENSEMBL:
Gene Tree for ZNF284 (if available)
TreeFam:
Gene Tree for ZNF284 (if available)

Paralogs for ZNF284 Gene

(390) SIMAP similar genes for ZNF284 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZNF284: view

Variants for ZNF284 Gene

Sequence variations from dbSNP and Humsavar for ZNF284 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs8113249 -, - 44,087,207(+) GCTAC(A/G)AGAGG reference, missense
rs4550576 -- 44,074,294(+) gttgc(A/G)gtgag intron-variant, upstream-variant-2KB
rs4553729 -- 44,081,923(+) atcaG(C/T)GTTCA intron-variant
rs6509139 -- 44,078,950(+) catgc(C/T)cggct intron-variant
rs4803673 -- 44,080,403(+) ACCAG(C/T)CTGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF284 Gene

Variant ID Type Subtype PubMed ID
nsv833840 CNV Gain 17160897

Variation tolerance for ZNF284 Gene

Residual Variation Intolerance Score: 79.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.53; 92.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF284 Gene

HapMap Linkage Disequilibrium report
ZNF284

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF284 Gene

Disorders for ZNF284 Gene

Relevant External Links for ZNF284

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF284

No disorders were found for ZNF284 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF284 Gene

Publications for ZNF284 Gene

  1. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. (PMID: 12743021) Shannon M. … Stubbs L. (Genome Res. 2003) 2 3 4 67
  2. Cloning and characterization of a novel KRAB-domain-containing zinc finger gene (ZNF284L). (PMID: 16817023) Yin G. … Mao Y. (Mol. Biol. Rep. 2006) 3

Products for ZNF284 Gene

Sources for ZNF284 Gene

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