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ZNF284 Gene

protein-coding   GIFtS: 43
GCID: GC19P044580

Zinc Finger Protein 284

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 2841 2
ZNF284L2 3

External Ids:    HGNC: 130781   Entrez Gene: 3429092   Ensembl: ENSG000001860267   UniProtKB: Q2VY693   

Export aliases for ZNF284 gene to outside databases

Previous GC identifers: GC00U990661 GC19P049252 GC19P049268 GC19U900427 GC19P044578 GC19P041008


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF284 Gene:
ZNF284 (zinc finger protein 284) is a protein-coding gene. An important paralog of this gene is ZNF229.

UniProtKB/Swiss-Prot: ZN284_HUMAN, Q2VY69
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF284 gene promoter:
         NCX/Ncx   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF284 promoter sequence
   Search Chromatin IP Primers for ZNF284

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF284


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.31   Ensembl cytogenetic band:  19q13.31   HGNC cytogenetic band: 19q13.32

ZNF284 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF284 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P044580:  view genomic region     (about GC identifiers)

Start:
44,576,297 bp from pter      End:
44,593,766 bp from pter
Size:
17,470 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZN284_HUMAN, Q2VY69 (See protein sequence)
Recommended Name: Zinc finger protein 284  
Size: 593 amino acids; 69019 Da
Secondary accessions: Q86WM1

Explore the universe of human proteins at neXtProt for ZNF284: NX_Q2VY69

Explore proteomics data for ZNF284 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys509, Lys512
  • Modification sites at PhosphoSitePlus

  • See ZNF284 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001032902.1  
    ENSEMBL proteins: 
     ENSP00000411032  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q2VY69

    ProtoNet protein and cluster: Q2VY69

    2 Blocks protein domains:
    IPB001909 KRAB box
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZN284_HUMAN, Q2VY69
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 15 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    Find genes that share domains with ZNF284           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN284_HUMAN, Q2VY69
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF284           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ZNF284

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN284_HUMAN, Q2VY69: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZNF284           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF284
    Interactions:

        Search GeneGlobe Interaction Network for ZNF284

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with ZNF284           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ZNF284 (ZN284)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF284 gene: 
    NM_001037813.2  

    Unigene Cluster for ZNF284:

    Zinc finger protein 284
    Hs.445395  [show with all ESTs]
    Unigene Representative Sequence: CR936662
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000421176(uc010ejd.2 uc002oyg.1)
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    Additional mRNA sequence: 

    AY166789.1 AY458845.1 CR936662.1 

    2 DOTS entries:

    DT.86837142  DT.100652115 

    11 AceView cDNA sequences:

    BM801442 AI765083 AI817781 BE858089 BM989725 AI559740 BQ775028 AI939473 
    AI161180 AI423725 BG122327 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF284 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATACAATGT
    ZNF284 Expression
    About this image

    ZNF284 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF284 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.445395

    UniProtKB/Swiss-Prot: ZN284_HUMAN, Q2VY69
    Tissue specificity: Expressed in lung, liver, pancreas and thymus. Lower expression in heart, placenta, spleen,
    prostate, ovary, small intestine and colon. No expression seen in brain, skeletal muscle, kidney, testis and
    peripheral blood leukocyte

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and chimp.

    Orthologs for ZNF284 gene from 1 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chimpanzee
    (Pan troglodytes)
    Mammalia ZNF2841 zinc finger protein 284 99.46(n)
    99.28(a)
      456103  XM_001146572.3  XP_001146572.3 


    ENSEMBL Gene Tree for ZNF284 (if available)
    TreeFam Gene Tree for ZNF284 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF284 gene
    ZNF2292  ZNF2232  ZNF2302  ZNF1552  ZNF2272  ZNF2242  ZNF2342  ZNF2252  
    ZNF2262  ZNF2142  ZNF2222  ENSG000002671732  ZNF452  ZNF2352  ZNF2212  ZNF2852  
    ENSG000002670222  ZNF1122  ZNF2332  
    Selected SIMAP similar genes for ZNF284 using alignment to 1 protein entry:     ZN284_HUMAN(see all similar genes):
    ZNF221    ZNF224    ZNF155    ZNF234    ZNF223    ZFS-1
    ZNF418    ZNF492    DKFZp686K03205    ZFP112    ZFP3    ZNF112
    ZNF117    ZNF146    ZNF225    ZNF229    ZNF501    ZNF658

    Find genes that share paralogs with ZNF284           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF284 (see all 431)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1906715111,2
    --44574574(+) TATCAA/TGTTTT 1 -- us2k10--------
    rs1818713871,2
    --44574576(+) TCATGG/TTTTTC 1 -- us2k10--------
    rs1468542981,2
    --44574643(+) GTTGAA/CAATGA 1 -- us2k10--------
    rs72555121,2
    C,F,H--44574700(+) CAGCAC/TTAAAA 1 -- us2k120Minor allele frequency- T:0.41NS EA NA WA CSA 2346
    rs1862704451,2
    --44574772(+) GAAACA/GTGCTT 1 -- us2k10--------
    rs1908745941,2
    --44574824(+) GATACA/GGTTTG 1 -- us2k10--------
    rs580026101,2
    --44574842(+) CTCCAC/TCCAAA 1 -- us2k10--------
    rs1128254371,2
    C,F--44574843(+) TCCACC/TCAAAT 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1132007761,2
    C,F--44574976(+) GAGTGT/ACTTTG 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs735582481,2
    C,F--44574986(+) GAATAG/AAATGG 1 -- us2k12Minor allele frequency- A:0.11WA 120

    HapMap Linkage Disequilibrium report for ZNF284 (44576297 - 44593766 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZNF284:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833840CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF284 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF284)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. (PubMed id 12743021)1, 2, 3 Shannon M.... Stubbs L. (Genome Res. 2003)
    2. Cloning and characterization of a novel KRAB-domain-containing zinc finger gene (ZNF284L). (PubMed id 16817023)1, 2 Yin G.... Mao Y. (Mol. Biol. Rep. 2006)
    3. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 342909 HGNC: 13078 AceView: ZNF284 Ensembl:ENSG00000186026 euGenes: HUgn342909
    ECgene: ZNF284 H-InvDB: ZNF284

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF284 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF284 gene:
    Search GeneIP for patents involving ZNF284

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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