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ZNF283 Gene

protein-coding   GIFtS: 39
GCID: GC19P044272

Zinc Finger Protein 283

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 2831 2
Zinc Finger Protein HZF192 3
HZF192
HZF412
Zinc Finger Protein 412

External Ids:    HGNC: 130771   Entrez Gene: 2843492   Ensembl: ENSG000001676377   UniProtKB: Q8N7M23   

Export aliases for ZNF283 gene to outside databases

Previous GC identifers: GC00U990662 GC19P049007 GC19P049023 GC19P049016


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF283 Gene:
ZNF283 (zinc finger protein 283) is a protein-coding gene. Diseases associated with ZNF283 include prostatitis, and breast cancer. An important paralog of this gene is ZNF334.

UniProtKB/Swiss-Prot: ZN283_HUMAN, Q8N7M2
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF283 gene promoter:
         POU2F1   POU2F1a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ZNF283

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF283


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.31   Ensembl cytogenetic band:  19q13.31   HGNC cytogenetic band: 19q13.31

ZNF283 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF283 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P044272:  view genomic region     (about GC identifiers)

Start:
44,331,444 bp from pter      End:
44,353,307 bp from pter
Size:
21,864 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ZN283_HUMAN, Q8N7M2 (See protein sequence)
Recommended Name: Zinc finger protein 283  
Size: 679 amino acids; 77942 Da
Sequence caution: Sequence=BAC05251.1; Type=Miscellaneous discrepancy; Note=Compared to the genome, the sequence
lacks 6 bp for unexplained reasons;
Secondary accessions: B4DGZ5 B7WP04 Q6RFR9 Q86WM6

Explore the universe of human proteins at neXtProt for ZNF283: NX_Q8N7M2

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • REFSEQ proteins: NP_862828.1  
    ENSEMBL proteins: 
     ENSP00000327314   ENSP00000468708   ENSP00000465054   ENSP00000468508   ENSP00000465942  
     ENSP00000467328   ENSP00000312519  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q8N7M2

    ProtoNet protein and cluster: Q8N7M2

    1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: ZN283_HUMAN, Q8N7M2
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 15 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF283 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN283_HUMAN, Q8N7M2
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IBA--
    GO:0046872metal ion binding IEA--
         
    ZNF283 for ontologies           About GeneDecksing


    Animal Models:
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    hsa-mir-877-5p (MIRT037343)

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    hsa-miR-513c hsa-miR-514b-5p
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN283_HUMAN, Q8N7M2: Nucleus (Probable)

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF283 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF283
    Interactions:

        Search GeneGlobe Interaction Network for ZNF283

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IBA--

    ZNF283 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF283 (ZN283)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZNF283 gene: 
    NM_181845.1  

    Unigene Cluster for ZNF283:

    Zinc finger protein 283
    Hs.652513  [show with all ESTs]
    Unigene Representative Sequence: AK294852
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000324461(uc002oxr.4 uc002oxp.4) ENST00000591203 ENST00000588797
    ENST00000586976 ENST00000590950 ENST00000593268 ENST00000588967 ENST00000593164
    ENST00000310738
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate ZNF283:
    hsa-miR-513c hsa-miR-514b-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat ZNF283
      QuantiFast Probe-based Assays in human, mouse, rat ZNF283

    Additional mRNA sequence: 

    AK098175.1 AK294852.1 AY166784.1 AY500359.1 AY500364.1 BC045755.2 

    5 DOTS entries:

    DT.100689708  DT.92416361  DT.438972  DT.91926158  DT.121499332 

    Selected AceView cDNA sequences (see all 27):

    BU101805 AA351493 AY166784 AI753038 BC045755 BE261849 AK098175 BP872606 
    BG715255 N57666 BF840630 AA351492 AY500359 BX473427 AY500364 AA082636 
    BV208044 BM688312 AV752188 BV208043 AA081943 AW080602 BG980994 BF959034 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF283 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAGAACTCA
    ZNF283 Expression
    About this image

    ZNF283 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

    SOURCE GeneReport for Unigene cluster: Hs.652513

    UniProtKB/Swiss-Prot: ZN283_HUMAN, Q8N7M2
    Tissue specificity: Detected in prostate, testis, and pancreas

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF283

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of mammals.

    Orthologs for ZNF283 gene from Selected species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia ZNF2831 zinc finger protein 283 86.11(n)
    81.96(a)
      613011  XM_005616474.1  XP_005616531.1 


    ENSEMBL Gene Tree for ZNF283 (if available)
    TreeFam Gene Tree for ZNF283 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF283 gene
    ZNF3342  ZNF4202  ZNF780A2  ZNF6652  ZNF72  ZNF232  ZNF33A2  RBAK2  
    ZNF7172  ZNF302  ZNF5732  ZNF33B2  ZNF5402  ZNF2512  ZNF6052  ZNF842  
    ZNF1892  ZNF5712  ZNF6302  ZNF3372  ZNF4042  ZNF1352  ZNF4842  ZNF122  
    ZNF3452  ZNF1842  ZNF6992  ZNF412  ZNF6152  ZNF4702  ZNF5692  
    Selected SIMAP similar genes for ZNF283 using alignment to 7 protein entries:     ZN283_HUMAN (see all proteins) (see all similar genes):
    HZF41    FIK    ZNF320    APOPT1    NRAMP1    ZNF78L1
    ZNF721    ZNF571    ZFP90    ZNF677    ZNF793    ZNF707
    ZNF519    ZNF850    ZNF431    ZNF140    AVGR4    AVGR5

    ZNF283 for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for ZNF283 (see all 12)
    PGOHUM00000258671 PGOHUM00000259211 PGOHUM00000259326 PGOHUM00000259327 PGOHUM00000259404


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF283 (see all 565)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1378794461,2
    --44329535(+) AGGCTA/GTAGTG 1 -- us2k10--------
    rs65091191,2
    C,A--44329548(+) atggcA/Gctatc 1 -- us2k10--------
    rs796861031,2
    C--44329570(+) CAATCA/TCCGCC 1 -- us2k11Minor allele frequency- T:0.00NA 2
    rs1922261521,2
    --44329574(+) CTCCAC/TCTCCC 1 -- us2k10--------
    rs753222171,2
    C--44329578(-) ACTCAG/CGAGGC 1 -- us2k11Minor allele frequency- C:0.50NA 2
    rs792939811,2
    F--44329643(-) CCGGGC/TGCGGT 1 -- us2k12Minor allele frequency- T:0.25NA 8
    rs761688981,2
    C,F--44329658(-) AATACA/G/TAAAAT 1 -- us2k13NA 10
    rs779543351,2
    F--44329668(+) TTTTAG/ATAGAG 1 -- us2k11Minor allele frequency- A:0.50NA 4
    rs1403978731,2
    --44329720(+) GACTTC/GAGGTG 1 -- us2k10--------
    rs72485241,2
    C,F--44329782(+) ATGCCC/TGGCCT 1 -- us2k13Minor allele frequency- T:0.13WA NA EA 358

    HapMap Linkage Disequilibrium report for ZNF283 (44331444 - 44353307 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ZNF283:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv458710CNV Loss19166990
    nsv524460CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF283
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF283

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases for ZNF283:    About MalaCards
    prostatitis    breast cancer


    ZNF283 for disorders           About GeneDecksing


    Export disorders for ZNF283 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF283 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF283)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. (PubMed id 12743021)1, 2, 3 Shannon M.... Stubbs L. (Genome Res. 2003)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937. (PubMed id 7865130)1, 2 Abrink M.... Hellman L. (DNA Cell Biol. 1995)
    4. Large-scale genotyping identifies 41 new loci associated with breast cancer risk. (PubMed id 23535729)1 Michailidou K....Easton D.F. (Nat. Genet. 2013)
    5. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 284349 HGNC: 13077 AceView: ZNF283 Ensembl:ENSG00000167637 euGenes: HUgn284349
    ECgene: ZNF283 H-InvDB: ZNF283

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF283 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF283 gene:
    Search GeneIP for patents involving ZNF283

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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