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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ZNF283 Gene

protein-coding GIFtS: 40
GCID: GC19P044272

Zinc Finger Protein 283

1 related disease
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Zinc Finger Protein 283¹ ²
Zinc Finger Protein HZF19² ³
HZF19²
HZF41²
Zinc Finger Protein 41²

External Ids:	HGNC: 13077¹	Entrez Gene: 284349²	Ensembl: ENSG00000167637⁷	UniProtKB: Q8N7M2³

Export aliases for ZNF283 gene to outside databases

Previous GC identifers: GC00U990662 GC19P049007 GC19P049023 GC19P049016

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF283 Gene:

ZNF283 (zinc finger protein 283) is a protein-coding gene. Diseases associated with ZNF283 include prostatitis. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF420.

UniProtKB/Swiss-Prot: ZN283_HUMAN, Q8N7M2

Function: May be involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NT_011109.16 NC_018930.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ZNF283 gene promoter:
POU2F1 POU2F1a
Other transcription factors

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Search SABiosciences Chromatin IP Primers for ZNF283

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF283

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.31 Ensembl cytogenetic band: 19q13.31 HGNC cytogenetic band: 19q13.31

ZNF283 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF283 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P044272: view genomic region (about GC identifiers)

Start:	44,331,444 bp from pter	End:	44,353,307 bp from pter
Size:	21,864 bases	Orientation:	plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN283_HUMAN, Q8N7M2 (See protein sequence)

Recommended Name: Zinc finger protein 283

Size: 679 amino acids; 77942 Da

Subcellular location: Nucleus (Probable)

Sequence caution: Sequence=BAC05251.1; Type=Miscellaneous discrepancy; Note=Compared to the genome, the sequence lacks

6 bp for unexplained reasons;

Secondary accessions: B4DGZ5 B7WP04 Q6RFR9 Q86WM6

Explore the universe of human proteins at neXtProt for ZNF283: NX_Q8N7M2

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q8N7M2

ZNF283 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : --

REFSEQ proteins: NP_862828.1

ENSEMBL proteins:

ENSP00000327314 ENSP00000468708 ENSP00000465054 ENSP00000468508 ENSP00000465942

ENSP00000467328 ENSP00000312519

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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005634	nucleus	IEA	--

ZNF283 for ontologies About GeneDecksing

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

ZNF: Zinc fingers, C2H2-type

4 InterPro protein domains:

IPR015880 Znf_C2H2-like

IPR001909 Krueppel-associated_box

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q8N7M2

ProtoNet protein and cluster: Q8N7M2

1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

UniProtKB/Swiss-Prot: ZN283_HUMAN, Q8N7M2

Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family

Similarity: Contains 15 C2H2-type zinc fingers

Similarity: Contains 1 KRAB domain

ZNF283 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ZN283_HUMAN, Q8N7M2

Function: May be involved in transcriptional regulation

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	--	--
GO:0003677	DNA binding	IEA	--
GO:0008270	zinc ion binding	--	--
GO:0046872	metal ion binding	IEA	--

ZNF283 for ontologies About GeneDecksing

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZNF283

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

ZNF283 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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Search CenterWatch for drugs/clinical trials and news about ZNF283 / ZN283

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for ZNF283 gene:

NM_181845.1

Unigene Cluster for ZNF283:

Zinc finger protein 283

Hs.652513 [show with all ESTs]

Unigene Representative Sequence: AK294852

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000324461(uc002oxr.4 uc002oxp.4) ENST00000591203 ENST00000588797

ENST00000586976 ENST00000590950 ENST00000593268 ENST00000588967 ENST00000593164

ENST00000310738

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Additional mRNA sequence:

AK098175.1 AK294852.1 AY166784.1 AY500359.1 AY500364.1 BC045755.2

5 DOTS entries:

DT.100689708 DT.92416361 DT.438972 DT.91926158 DT.121499332

24/27 AceView cDNA sequences (see all 27):

AY166784 BU101805 AA351493 BC045755 AA351492 AY500364 N57666 BP872606

BX473427 AK098175 BG715255 AI753038 BF840630 AY500359 BE261849 BV208044

AV752188 AA081943 BV208043 AA082636 BM688312 AW080602 BG980994 BF959034

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZNF283 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AGAGAACTCA

About this image

Genevestigator expression for ZNF283

SOURCE GeneReport for Unigene cluster: Hs.652513

UniProtKB/Swiss-Prot: ZN283_HUMAN, Q8N7M2

Tissue specificity: Detected in prostate, testis, and pancreas

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of mammals.

Orthologs for ZNF283 gene from 1/4 species (see all 4) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
dog (Canis familiaris)	Mammalia	ZNF283¹	zinc finger protein 283	91.31(n) 89.64(a)		613011 XM_850120.3 XP_855213.3

ENSEMBL Gene Tree for ZNF283 (if available)
TreeFam Gene Tree for ZNF283 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ZNF283 gene

ZNF420² ZNF780A² ZNF665² ZNF724P² ZNF7² ZNF23² ZNF432² ZNF33A²

ZNF234² ZNF30² ZNF573² ZNF429² ZNF540² ZNF251² ZNF605² ZNF84²

ZNF189² ZNF571² ZNF630² ZNF93² ZNF16² ZNF347² ZNF484² ZNF135²

ZNF184² ZNF585B² ZNF41² ZNF615² ZNF569² ZNF470²

18/604 SIMAP similar genes for ZNF283 using alignment to 7 protein entries: ZN283_HUMAN (see all proteins) (see all similar genes):

HZF41 FIK ZNF320 APOPT1 NRAMP1 ZNF78L1

ZNF431 ZNF677 ZNF721 ZNF571 ZFP90 ZNF845

ZNF615 ZNF793 ZNF83 ZNF707 ZNF519 ZNF850

ZNF283 for paralogs About GeneDecksing

5/12 Pseudogenes.org Pseudogenes for ZNF283 (see all 12)
PGOHUM00000258671 PGOHUM00000259211 PGOHUM00000259326 PGOHUM00000259327 PGOHUM00000259404

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs137879446^1,2		--	44329535(+)	`AGGCTA/GTAGTG`	1	--	us2k¹		0	--	--	--	--
rs6509119^1,2	C,A	--	44329548(+)	`atggcA/Gctatc`	1	--	us2k¹		0	--	--	--	--
rs79686103^1,2	C	--	44329570(+)	`CAATCA/TCCGCC`	1	--	us2k¹		1		NA	2
rs192226152^1,2		--	44329574(+)	`CTCCAC/TCTCCC`	1	--	us2k¹		0	--	--	--	--
rs75322217^1,2	C	--	44329578(-)	`ACTCAG/CGAGGC`	1	--	us2k¹		1		NA	2
rs79293981^1,2	F	--	44329643(-)	`CCGGGC/TGCGGT`	1	--	us2k¹		2		NA	8
rs76168898^1,2	C,F	--	44329658(-)	`AATACA/G/TAAAAT`	1	--	us2k¹		3		NA	10
rs77954335^1,2	F	--	44329668(+)	`TTTTAG/ATAGAG`	1	--	us2k¹		1		NA	4
rs140397873^1,2		--	44329720(+)	`GACTTC/GAGGTG`	1	--	us2k¹		0	--	--	--	--
rs7248524^1,2	C,F	--	44329782(+)	`ATGCCC/TGGCCT`	1	--	us2k¹		3		WA NA EA	358

HapMap Linkage Disequilibrium report for ZNF283 (44331444 - 44353307 bp)

Structural Variations
Database of Genomic Variants (DGV) 2 variations for ZNF283: About this table

Variant ID	Type	Subtype	PubMed ID
nsv458710	CNV	Loss	19166990
nsv524460	CNV	Loss	19592680

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ZNF283 for disorders About GeneDecksing

2 diseases for ZNF283: About MalaCards

prostatitis

Export disorders for ZNF283 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZNF283 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF283)

Utopia: connect your pdf to the dynamic
world of online information

Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. (PubMed id 12743021)^{1, 2, 3} Shannon M.... Stubbs L. (2003)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937. (PubMed id 7865130)^{1, 2} Abrink M.... Hellman L. (1995)
Large-scale genotyping identifies 41 new loci associat ed with breast cancer risk. (PubMed id 23535729)¹ Michailidou K....Easton D.F. (2013)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)² Grimwood J.... Lucas S.M. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 284349	HGNC: 13077	AceView: ZNF283	Ensembl:ENSG00000167637	euGenes: HUgn284349
ECgene: ZNF283	H-InvDB: ZNF283

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ZNF283	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZNF283 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ZNF283 gene:
Search GeneIP for patents involving ZNF283

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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About This Section


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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013

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Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
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Hot genes Disease genes ZNF283 gene at Home site.

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ZNF283 Gene

Zinc Finger Protein 283

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ZNF283 Gene

Zinc Finger Protein 283

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