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ZNF283 Gene(Protein Coding)

Zinc Finger Protein 283

GCID:
GC19P043827
GIFtS:
39
Genes Participants
UDN Logo

Aliases for ZNF283 Gene

Aliases for ZNF283 Gene

  • Zinc Finger Protein 283 2 3 5
  • Zinc Finger Protein HZF19 3 4
  • Zinc Finger Protein 41 3
  • HZF19 3
  • HZF41 3

External Ids for ZNF283 Gene

Previous GeneCards Identifiers for ZNF283 Gene

  • GC00U990662
  • GC19P049007
  • GC19P049023
  • GC19P049016
  • GC19P044272

Summaries for ZNF283 Gene

GeneCards Summary for ZNF283 Gene

ZNF283 (Zinc Finger Protein 283) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF345.

UniProtKB/Swiss-Prot for ZNF283 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF283 Gene

Genomics for ZNF283 Gene

Products:

  1. Regulatory Element

Regulatory Elements for ZNF283 Gene

Enhancers for ZNF283 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF283 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF283 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF283 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the ZNF283 gene promoter:

Genomic Location for ZNF283 Gene

Chromosome:
19
Start:
43,827,292 bp from pter
End:
43,852,017 bp from pter
Size:
24,726 bases
Orientation:
Plus strand

Genomic View for ZNF283 Gene

Genes around ZNF283 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF283 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF283 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ZNF283 Gene

Proteins for ZNF283 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for ZNF283 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N7M2-ZN283_HUMAN
    Recommended name:
    Zinc finger protein 283
    Protein Accession:
    Q8N7M2
    Secondary Accessions:
    • B4DGZ5
    • B7WP04
    • Q6RFR9
    • Q86WM6

    Protein attributes for ZNF283 Gene

    Size:
    679 amino acids
    Molecular mass:
    77942 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05251.1; Type=Miscellaneous discrepancy; Note=Compared to the genome, the sequence lacks 6 bp for unexplained reasons.; Evidence={ECO:0000305};

neXtProt entry for ZNF283 Gene

Proteomics data for ZNF283 Gene at MOPED

Protein Expression for ZNF283 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ZNF283 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF283 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF283 Gene

Domains & Families for ZNF283 Gene

Gene Families for ZNF283 Gene

HGNC:

Protein Domains for ZNF283 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF283 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N7M2

UniProtKB/Swiss-Prot:

ZN283_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 15 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 15 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF283: view

Function for ZNF283 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for ZNF283 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes for ZNF283 Gene

GenomeRNAi human phenotypes for ZNF283:
genes like me logo Genes that share phenotypes with ZNF283: view

Animal Model Products

CRISPR Products

miRNA for ZNF283 Gene

miRTarBase miRNAs that target ZNF283

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF283 Gene

Localization for ZNF283 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF283 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF283 Gene COMPARTMENTS Subcellular localization image for ZNF283 gene
Compartment Confidence
nucleus 3

No data available for Gene Ontology (GO) - Cellular Components for ZNF283 Gene

Pathways & Interactions for ZNF283 Gene

SuperPathways for ZNF283 Gene

PathCards logoMore details on SuperPathways for ZNF283
No Data Available

Interacting Proteins for ZNF283 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000327314%0d%0a9606.ENSP00000264705%0d%0a9606.ENSP00000336687%0d%0a9606.ENSP00000455507%0d%0a9606.ENSP00000276072%0d%0a9606.ENSP00000418379%0d%0a
Selected Interacting proteins: ENSP00000327314 for ZNF283 Gene via STRING

Gene Ontology (GO) - Biological Process for ZNF283 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZNF283 Gene

Drugs & Compounds for ZNF283 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for ZNF283 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for ZNF283 Gene

(8) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(27) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF283 Gene

Zinc finger protein 283:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF283 Gene

No ASD Table

Relevant External Links for ZNF283 Gene

GeneLoc Exon Structure for
ZNF283
ECgene alternative splicing isoforms for
ZNF283

Expression for ZNF283 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for ZNF283 Gene

mRNA expression in normal human tissues for ZNF283 Gene
mRNA expression by BioGPS for ZNF283 GenemRNA expression by GTEx for ZNF283 Gene

Protein differential expression in normal tissues from HIPED for ZNF283 Gene

This gene is overexpressed in Spinal cord (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF283 Gene



SOURCE GeneReport for Unigene cluster for ZNF283 Gene Hs.652513

mRNA Expression by UniProt/SwissProt for ZNF283 Gene

Q8N7M2-ZN283_HUMAN
Tissue specificity: Detected in prostate, testis, and pancreas.
genes like me logo Genes that share expression patterns with ZNF283: view

Protein tissue co-expression partners for ZNF283 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZNF283 Gene

Orthologs for ZNF283 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF283 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia ZNF283 35
  • 90.06 (n)
  • 86.66 (a)
ZNF283 36
  • 81 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia ZNF283 35
  • 86.11 (n)
  • 81.96 (a)
ZNF283 36
  • 90 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia ZNF283 35
  • 96.76 (n)
  • 94.26 (a)
ZNF283 36
  • 83 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia -- 36
  • 46 (a)
 OneToMany
Species with no ortholog for ZNF283:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF283 Gene

ENSEMBL:
Gene Tree for ZNF283 (if available)
TreeFam:
Gene Tree for ZNF283 (if available)

Paralogs for ZNF283 Gene

Paralogs for ZNF283 Gene

(607) SIMAP similar genes for ZNF283 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for ZNF283 Gene

genes like me logo Genes that share paralogs with ZNF283: view

Variants for ZNF283 Gene

Sequence variations from dbSNP and Humsavar for ZNF283 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1061768 - 43,848,487(+) TCAAC(A/G)TAAGG reference, missense
rs10417624 - 43,848,538(+) TGAGA(G/T)AACTC reference, missense
rs2195980 - 43,847,542(+) TCATA(C/T)TGGTG reference, missense
rs2356437 - 43,848,513(+) TTACT(C/T)GTGGC reference, missense
rs1061769 - 43,848,514(+) TACTT(A/G)TGGCT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ZNF283 Gene

Variant ID Type Subtype PubMed ID
nsv458710 CNV Loss 19166990
nsv524460 CNV Loss 19592680

Variation tolerance for ZNF283 Gene

Residual Variation Intolerance Score: 84.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.43; 96.39% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF283 Gene

Disorders for ZNF283 Gene

Relevant External Links for ZNF283

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF283

No disorders were found for ZNF283 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF283 Gene

Publications for ZNF283 Gene

  1. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. (PMID: 12743021) Shannon M. … Stubbs L. (Genome Res. 2003) 2 3 4 67
  2. Large-scale genotyping identifies 41 new loci associated with breast cancer risk. (PMID: 23535729) Michailidou K. … Easton D.F. (Nat. Genet. 2013) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937. (PMID: 7865130) Abrink M. … Hellman L. (DNA Cell Biol. 1995) 3

Products for ZNF283 Gene

Sources for ZNF283 Gene

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