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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF283 Gene

protein-coding   GIFtS: 40
GCID: GC19P044272

Zinc Finger Protein 283

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 2831 2
Zinc Finger Protein HZF192 3
HZF192
HZF412
Zinc Finger Protein 412

External Ids:    HGNC: 130771   Entrez Gene: 2843492   Ensembl: ENSG000001676377   UniProtKB: Q8N7M23   

Export aliases for ZNF283 gene to outside databases

Previous GC identifers: GC00U990662 GC19P049007 GC19P049023 GC19P049016


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF283 Gene: 
ZNF283 (zinc finger protein 283) is a protein-coding gene. Diseases associated with ZNF283 include prostatitis. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF420.

UniProtKB/Swiss-Prot: ZN283_HUMAN, Q8N7M2
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF283 gene promoter:
         POU2F1   POU2F1a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ZNF283

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF283


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.31   Ensembl cytogenetic band:  19q13.31   HGNC cytogenetic band: 19q13.31

ZNF283 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF283 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P044272:  view genomic region     (about GC identifiers)

Start:
44,331,444 bp from pter      End:
44,353,307 bp from pter
Size:
21,864 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN283_HUMAN, Q8N7M2 (See protein sequence)
Recommended Name: Zinc finger protein 283  
Size: 679 amino acids; 77942 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=BAC05251.1; Type=Miscellaneous discrepancy; Note=Compared to the genome, the sequence
lacks 6 bp for unexplained reasons;
Secondary accessions: B4DGZ5 B7WP04 Q6RFR9 Q86WM6

Explore the universe of human proteins at neXtProt for ZNF283: NX_Q8N7M2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N7M2

  • ZNF283 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins: NP_862828.1  
    ENSEMBL proteins: 
     ENSP00000327314   ENSP00000468708   ENSP00000465054   ENSP00000468508   ENSP00000465942  
     ENSP00000467328   ENSP00000312519  

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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF283 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q8N7M2

    ProtoNet protein and cluster: Q8N7M2

    1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: ZN283_HUMAN, Q8N7M2
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 15 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF283 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN283_HUMAN, Q8N7M2
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF283 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF283

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF283 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
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    Search CenterWatch for drugs/clinical trials and news about ZNF283 / ZN283

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for ZNF283 gene: 
    NM_181845.1  

    Unigene Cluster for ZNF283:

    Zinc finger protein 283
    Hs.652513  [show with all ESTs]
    Unigene Representative Sequence: AK294852
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000324461(uc002oxr.4 uc002oxp.4) ENST00000591203 ENST00000588797
    ENST00000586976 ENST00000590950 ENST00000593268 ENST00000588967 ENST00000593164
    ENST00000310738
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    hsa-miR-513c hsa-miR-514b-5p
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    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    Additional mRNA sequence: 

    AK098175.1 AK294852.1 AY166784.1 AY500359.1 AY500364.1 BC045755.2 

    5 DOTS entries:

    DT.100689708  DT.92416361  DT.438972  DT.91926158  DT.121499332 

    24/27 AceView cDNA sequences (see all 27):

    AY166784 BU101805 AA351493 BC045755 AA351492 AY500364 N57666 BP872606 
    BX473427 AK098175 BG715255 AI753038 BF840630 AY500359 BE261849 BV208044 
    AV752188 AA081943 BV208043 AA082636 BM688312 AW080602 BG980994 BF959034 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF283 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAGAACTCA
    ZNF283 Expression
    About this image


    Genevestigator expression for ZNF283

    SOURCE GeneReport for Unigene cluster: Hs.652513

    UniProtKB/Swiss-Prot: ZN283_HUMAN, Q8N7M2
    Tissue specificity: Detected in prostate, testis, and pancreas

        SABiosciences Custom PCR Arrays for ZNF283
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF283

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of mammals.

    Orthologs for ZNF283 gene from 1/4 species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia ZNF2831 zinc finger protein 283 91.31(n)
    89.64(a)
      613011  XM_850120.3  XP_855213.3 


    ENSEMBL Gene Tree for ZNF283 (if available)
    TreeFam Gene Tree for ZNF283 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF283 gene
    ZNF4202  ZNF780A2  ZNF6652  ZNF724P2  ZNF72  ZNF232  ZNF4322  ZNF33A2  
    ZNF2342  ZNF302  ZNF5732  ZNF4292  ZNF5402  ZNF2512  ZNF6052  ZNF842  
    ZNF1892  ZNF5712  ZNF6302  ZNF932  ZNF162  ZNF3472  ZNF4842  ZNF1352  
    ZNF1842  ZNF585B2  ZNF412  ZNF6152  ZNF5692  ZNF4702  
    18/604 SIMAP similar genes for ZNF283 using alignment to 7 protein entries:     ZN283_HUMAN (see all proteins) (see all similar genes):
    HZF41    FIK    ZNF320    APOPT1    NRAMP1    ZNF78L1
    ZNF431    ZNF677    ZNF721    ZNF571    ZFP90    ZNF845
    ZNF615    ZNF793    ZNF83    ZNF707    ZNF519    ZNF850

    ZNF283 for paralogs           About GeneDecksing


    5/12 Pseudogenes.org Pseudogenes for ZNF283 (see all 12)
    PGOHUM00000258671 PGOHUM00000259211 PGOHUM00000259326 PGOHUM00000259327 PGOHUM00000259404


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/565 SNPs in ZNF283 are shown (see all 565)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1378794461,2
    --44329535(+) AGGCTA/GTAGTG 1 -- us2k10--------
    rs65091191,2
    C,A--44329548(+) atggcA/Gctatc 1 -- us2k10--------
    rs796861031,2
    C--44329570(+) CAATCA/TCCGCC 1 -- us2k11Minor allele frequency- T:0.00NA 2
    rs1922261521,2
    --44329574(+) CTCCAC/TCTCCC 1 -- us2k10--------
    rs753222171,2
    C--44329578(-) ACTCAG/CGAGGC 1 -- us2k11Minor allele frequency- C:0.50NA 2
    rs792939811,2
    F--44329643(-) CCGGGC/TGCGGT 1 -- us2k12Minor allele frequency- T:0.25NA 8
    rs761688981,2
    C,F--44329658(-) AATACA/G/TAAAAT 1 -- us2k13NA 10
    rs779543351,2
    F--44329668(+) TTTTAG/ATAGAG 1 -- us2k11Minor allele frequency- A:0.50NA 4
    rs1403978731,2
    --44329720(+) GACTTC/GAGGTG 1 -- us2k10--------
    rs72485241,2
    C,F--44329782(+) ATGCCC/TGGCCT 1 -- us2k13Minor allele frequency- T:0.13WA NA EA 358

    HapMap Linkage Disequilibrium report for ZNF283 (44331444 - 44353307 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ZNF283:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv458710CNV Loss19166990
    nsv524460CNV Loss19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for ZNF283:    About MalaCards
    prostatitis    


    ZNF283 for disorders           About GeneDecksing


    Export disorders for ZNF283 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF283 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF283)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. (PubMed id 12743021)1, 2, 3 Shannon M.... Stubbs L. (2003)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937. (PubMed id 7865130)1, 2 Abrink M.... Hellman L. (1995)
    4. Large-scale genotyping identifies 41 new loci associat ed with breast cancer risk. (PubMed id 23535729)1 Michailidou K....Easton D.F. (2013)
    5. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 284349 HGNC: 13077 AceView: ZNF283 Ensembl:ENSG00000167637 euGenes: HUgn284349
    ECgene: ZNF283 H-InvDB: ZNF283

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF283 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF283 gene:
    Search GeneIP for patents involving ZNF283

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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