Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ZNF282 Gene

protein-coding   GIFtS: 53
GCID: GC07P148892

Zinc Finger Protein 282

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Zinc Finger Protein 2821 2
HUB12 3 5
HUB-12 3
HTLV-I U5RE-Binding Protein 12 3
HTLV-I U5 Repressive Element-Binding Protein 12

External Ids:    HGNC: 130761   Entrez Gene: 84272   Ensembl: ENSG000001702657   OMIM: 6033975   UniProtKB: Q9UDV73   

Export aliases for ZNF282 gene to outside databases

Previous GC identifers: GC07P147139 GC07P148207 GC07P148284 GC07P148216 GC07P148330 GC07P148523 GC07P142969


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for ZNF282 Gene:
ZNF282 (zinc finger protein 282) is a protein-coding gene. Diseases associated with ZNF282 include adult t-cell leukemia, and t-cell leukemia. An important paralog of this gene is ZNF777.

UniProtKB/Swiss-Prot: ZN282_HUMAN, Q9UDV7
Function: Binds to the U5 repressive element (U5RE) of the human T cell leukemia virus type I long terminal
repeat. It recognizes the 5'-TCCACCCC-3' sequence as a core motif and exerts a strong repressive effect on HTLV-I
LTR-mediated expression




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF282 gene promoter:
         Max1   AML1a   NRSF form 1   Olf-1   Ik-3   NRSF form 2   AREB6   Pax-4a   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): ZNF282 promoter sequence
   Search Chromatin IP Primers for ZNF282

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF282


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q36.1   Ensembl cytogenetic band:  7q36.1   HGNC cytogenetic band: 7q36.1

ZNF282 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF282 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P148892:  view genomic region     (about GC identifiers)

Start:
148,892,577 bp from pter      End:
148,923,339 bp from pter
Size:
30,763 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 148,230,571-148,261,360     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ZN282_HUMAN, Q9UDV7 (See protein sequence)
Recommended Name: Zinc finger protein 282  
Size: 671 amino acids; 74295 Da
Sequence caution: Sequence=BAA24380.1; Type=Erroneous initiation;
Secondary accessions: O43691 Q6DKK0

Explore the universe of human proteins at neXtProt for ZNF282: NX_Q9UDV7

Explore proteomics data for ZNF282 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys228
  • Modification sites at PhosphoSitePlus

  • See ZNF282 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003566.1  
    ENSEMBL proteins: 
     ENSP00000262085   ENSP00000418840  
    Reactome Protein details: Q9UDV7

    ZNF282 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ZNF282
    GenScript Custom Purified and Recombinant Proteins Services for ZNF282
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZNF282

    ZNF282 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ZNF282
    Novus Biologicals ZNF282 Antibodies
    Abcam antibodies for ZNF282
    Cloud-Clone Corp. Antibodies for ZNF282
    ThermoFisher Antibodies for ZNF282
    LSBio Antibodies in human, mouse, rat for ZNF282

    ZNF282 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ZNF282
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ZNF282
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ZNF282
    Cloud-Clone Corp. CLIAs for ZNF282


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    5 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR022137 DUF3669_Znf
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9UDV7

    ProtoNet protein and cluster: Q9UDV7

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN282_HUMAN, Q9UDV7
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 5 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF282 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN282_HUMAN, Q9UDV7
    Function: Binds to the U5 repressive element (U5RE) of the human T cell leukemia virus type I long terminal
    repeat. It recognizes the 5'-TCCACCCC-3' sequence as a core motif and exerts a strong repressive effect on HTLV-I
    LTR-mediated expression

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding NAS9396811
    GO:0046872metal ion binding ----
         
    ZNF282 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF282
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ZNF282

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZNF282
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZNF282

    miRNA
    Products:
        
    miRTarBase miRNAs that target ZNF282:
    hsa-mir-320a (MIRT044473), hsa-mir-92a-3p (MIRT049614), hsa-mir-92b-3p (MIRT040540), hsa-mir-3177-3p (MIRT052800), hsa-mir-744-5p (MIRT037429)

    Block miRNA regulation of human, mouse, rat ZNF282 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZNF282 (see all 58):
    hsa-miR-142-5p hsa-miR-3938 hsa-let-7d hsa-miR-503 hsa-miR-29a hsa-miR-301a hsa-miR-449a hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidZNF282 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ZNF282
    Predesigned siRNA for gene silencing in human, mouse, rat ZNF282

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ZNF282

    Clone
    Products:
         
    OriGene clones in human, mouse for ZNF282 (see all 7)
    OriGene ORF clones in mouse, rat for ZNF282
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ZNF282 (NM_003575)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZNF282
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF282

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ZNF282
    Browse ESI BIO Cell Lines and PureStem Progenitors for ZNF282 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF282


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ZN282_HUMAN, Q9UDV7: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF282 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for ZNF282 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF282
        Generic Transcription Pathway



    ZNF282 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF282
    Interactions:

        Search GeneGlobe Interaction Network for ZNF282

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for ZNF282 (Q9UDV72, 3 ENSP000002620854) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPKAPK5Q8IW412, 3MINT-8262808 I2D: score=2 
    PIK3CGP487362, 3, ENSP000003521214MINT-8266183 I2D: score=2 STRING: ENSP00000352121
    PKN1Q165122, 3, ENSP000003433254MINT-8266645 I2D: score=2 STRING: ENSP00000343325
    SLX4Q8IY923, ENSP000002940084I2D: score=1 STRING: ENSP00000294008
    SUMO2ENSP000004059654STRING: ENSP00000405965
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated TAS9396811
    GO:0045892negative regulation of transcription, DNA-templated TAS9396811

    ZNF282 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF282 (ZN282)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ZNF282 gene: 
    NM_003575.2  

    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262085(uc011kun.1 uc003wfm.3 uc003wfo.3) ENST00000479907(uc003wfn.3)
    ENST00000462740 ENST00000470381
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ZNF282 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZNF282 (see all 58):
    hsa-miR-142-5p hsa-miR-3938 hsa-let-7d hsa-miR-503 hsa-miR-29a hsa-miR-301a hsa-miR-449a hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidZNF282 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ZNF282
    Predesigned siRNA for gene silencing in human, mouse, rat ZNF282
    Clone
    Products:
         
    OriGene clones in human, mouse for ZNF282 (see all 7)
    OriGene ORF clones in mouse, rat for ZNF282
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ZNF282 (NM_003575)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZNF282
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF282
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ZNF282
    OriGene qSTAR qPCR primer pairs in human, mouse for ZNF282
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZNF282
      QuantiTect SYBR Green Assays in human, mouse, rat ZNF282
      QuantiFast Probe-based Assays in human, mouse, rat ZNF282

    Selected AceView cDNA sequences (see all 155):

    BQ421181 BX281429 BC073805 BI964231 CR615805 AI818124 CA426110 BI255957 
    BQ445937 AU119822 AI373372 AA676828 BU736491 BX341719 AI569706 AI634482 
    AA476663 BM553048 AW275925 NM_003575 AA379678 BC041704 BM752577 CR603646 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ZNF282 expression in normal human tissues (normalized intensities)      ZNF282 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCACAGAGC
    ZNF282 Expression
    About this image


    ZNF282 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    ZNF282 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF282 Protein Expression

    UniProtKB/Swiss-Prot: ZN282_HUMAN, Q9UDV7
    Tissue specificity: Ubiquitous

        Custom PCR Arrays for ZNF282
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ZNF282
    OriGene qSTAR qPCR primer pairs in human, mouse for ZNF282
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZNF282
    QuantiTect SYBR Green Assays in human, mouse, rat ZNF282
    QuantiFast Probe-based Assays in human, mouse, rat ZNF282
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF282

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF282 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp2821 , 5 zinc finger protein 2821, 5 86.34(n)1
    89.83(a)1
      6 (22.94 cM)5
    1010951  NM_146175.31  NP_666287.31 
     478772045 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    56(a)
    1 → many
    2(539156-543542)
    lizard
    (Anolis carolinensis)
    Reptilia ZNF2826
    zinc finger protein 282
    45(a)
    1 ↔ 1
    GL343332.1(1103615-1109661)


    ENSEMBL Gene Tree for ZNF282 (if available)
    TreeFam Gene Tree for ZNF282 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ZNF282 gene
    ZNF7772  ZNF2122  ZNF7462  ZNF3982  ZNF7832  
    Selected SIMAP similar genes for ZNF282 using alignment to 4 protein entries:     ZN282_HUMAN (see all proteins) (see all similar genes):
    ZNF767    LOC155060    ZNF211    ZNF84    DKFZp666M039    ZNF26
    ZNF551    ZNF586    ZNF79    ZNF836    ZNF283    HZF36
    ZNF189    ZNF260    ZNF286A    ZNF286B    ZNF300    ZNF420

    ZNF282 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ZNF282 (see all 737)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs770068831,2
    F--148890634(+) AATGCT/CCGCTA 1 -- us2k11Minor allele frequency- C:0.02WA 118
    rs69803841,2
    C,F--148890892(+) CTCCTC/GCATCT 1 -- us2k1 trp31Minor allele frequency- G:0.04WA 118
    rs119742851,2
    C,H--148890894(+) CCTCCA/GTCTTC 1 -- us2k10--------
    rs606832181,2
    --148890966(+) CACTGA/GCCTGC 1 -- us2k10--------
    rs1916479481,2
    --148890980(+) TAAAGA/GGTTTT 1 -- us2k10--------
    rs1172031071,2
    C,F--148890981(+) AAAGGG/TTTTTA 1 -- us2k11Minor allele frequency- T:0.03EA 120
    rs1830595871,2
    --148891032(+) TTGAAC/GTCCTG 1 -- us2k10--------
    rs12024711,2
    C,F,H--148891161(+) ggagcG/Acaacg 1 -- us2k1 tfbs315Minor allele frequency- A:0.03NS NA WA CSA EA 1038
    rs1447300101,2
    --148891304(+) TTATTA/TTTATT 1 -- us2k10--------
    rs578478931,2
    --148891307(+) TTATTA/TTTTTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZNF282 (148892577 - 148923339 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ZNF282:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv465196CNV Loss19166990
    nsv889402CNV Loss21882294
    nsv518773CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF282
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF282

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 603397    OMIM disorders: --

    8 diseases for ZNF282:    About MalaCards
    adult t-cell leukemia    t-cell leukemia    tonsillitis    leukemia
    thyroiditis    cerebritis    endotheliitis    prostatitis


    ZNF282 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZNF282
    Human Genome Epidemiology (HuGE) Navigator: ZNF282 (1 document)

    Export disorders for ZNF282 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ZNF282 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with ZNF282)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. HUB1, a novel Kruppel type zinc finger protein, represses the human T cell leukemia virus type I long terminal repeat-mediated expression. (PubMed id 9396811)1, 2, 3, 9 Okumura K.... Igarashi H. (Nucleic Acids Res. 1997)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    5. SUMOylation of ZFP282 potentiates its positive effect on estrogen signaling in breast tumorigenesis. (PubMed id 22986521)1 Yu E.J....Kim J.H. (Oncogene 2013)
    6. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    7. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. Comparative proteomic analysis identifies a role for SUMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (Sci Signal 2011)
    10. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 8427 HGNC: 13076 AceView: ZNF282 Ensembl:ENSG00000170265 euGenes: HUgn8427
    ECgene: ZNF282 H-InvDB: ZNF282

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ZNF282 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ZNF282 gene:
    Search GeneIP for patents involving ZNF282

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ZNF282  
     OriGene qPCR primer pairs and template standards for ZNF282   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ZNF282  
     OriGene qSTAR qPCR primer pairs in human, mouse for ZNF282   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ZNF282   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ZNF282   OriGene Custom Protein Services for ZNF282  

     
     
     Block miRNA regulation of human, mouse, rat ZNF282 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ZNF282
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF282 Predesigned siRNA for gene silencing in human, mouse, rat ZNF282
     QuantiFast Probe-based Assays in human, mouse, rat ZNF282 QuantiTect SYBR Green Assays in human, mouse, rat ZNF282
     Custom PCR Arrays for ZNF282 Search Chromatin IP Primers for ZNF282
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZNF282  Search GeneGlobe Interaction Network for ZNF282
     Regulatory tfbs in ZNF282 promoter
     GenScript Custom Purified and Recombinant Proteins Services for ZNF282 GenScript cDNA clones with any tag delivered in your preferred vector for ZNF282
     GenScript Custom Assay Services for ZNF282 GenScript Custom overexpressing Cell Line Services for ZNF282
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for ZNF282 (ZN282)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ZNF282 antibodies
     Antibodies for ZNF282
     See all of Abcam's Antibodies, Kits and Proteins for ZNF282
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for ZNF282
     Antibodies for ZNF282
     ELISAs for ZNF282
     CLIAs for ZNF282



     Browse ESI BIO Cell Lines and PureStem Progenitors for ZNF282
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF282
     SwitchGear 3'UTR luciferase reporter plasmids for ZNF282
     SwitchGear Promoter luciferase reporter plasmids for ZNF282
     ThermoFisher Antibodies for ZNF282
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF282
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF282
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ZNF282
     LSBio Antibodies in human, mouse, rat for ZNF282
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ZNF282 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4