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Aliases for ZNF282 Gene

Aliases for ZNF282 Gene

  • Zinc Finger Protein 282 2 3
  • HUB1 3 4 6
  • HTLV-I U5RE-Binding Protein 1 3 4
  • HUB-1 3 4
  • HTLV-I U5 Repressive Element-Binding Protein 1 3

External Ids for ZNF282 Gene

Previous GeneCards Identifiers for ZNF282 Gene

  • GC07P147139
  • GC07P148207
  • GC07P148284
  • GC07P148216
  • GC07P148330
  • GC07P148523
  • GC07P148892
  • GC07P142969

Summaries for ZNF282 Gene

GeneCards Summary for ZNF282 Gene

ZNF282 (Zinc Finger Protein 282) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF746.

UniProtKB/Swiss-Prot for ZNF282 Gene

  • Binds to the U5 repressive element (U5RE) of the human T cell leukemia virus type I long terminal repeat. It recognizes the 5-TCCACCCC-3 sequence as a core motif and exerts a strong repressive effect on HTLV-I LTR-mediated expression

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF282 Gene

Genomics for ZNF282 Gene

Regulatory Elements for ZNF282 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF282 Gene

Start:
149,195,472 bp from pter
End:
149,226,248 bp from pter
Size:
30,777 bases
Orientation:
Plus strand

Genomic View for ZNF282 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF282 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF282 Gene

Proteins for ZNF282 Gene

  • Protein details for ZNF282 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UDV7-ZN282_HUMAN
    Recommended name:
    Zinc finger protein 282
    Protein Accession:
    Q9UDV7
    Secondary Accessions:
    • B4DRI5
    • O43691
    • Q6DKK0

    Protein attributes for ZNF282 Gene

    Size:
    671 amino acids
    Molecular mass:
    74295 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA24380.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF282 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF282 Gene

Proteomics data for ZNF282 Gene at MOPED

Post-translational modifications for ZNF282 Gene

  • Ubiquitination at Lys228
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF282 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ZNF282 Gene

Domains for ZNF282 Gene

Gene Families for ZNF282 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF282 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UDV7

UniProtKB/Swiss-Prot:

ZN282_HUMAN :
  • Q9UDV7
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 5 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF282: view

Function for ZNF282 Gene

Molecular function for ZNF282 Gene

UniProtKB/Swiss-Prot Function:
Binds to the U5 repressive element (U5RE) of the human T cell leukemia virus type I long terminal repeat. It recognizes the 5-TCCACCCC-3 sequence as a core motif and exerts a strong repressive effect on HTLV-I LTR-mediated expression

Gene Ontology (GO) - Molecular Function for ZNF282 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0008270 zinc ion binding NAS 9396811
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with ZNF282: view

Animal Model Products

CRISPR Products

miRNA for ZNF282 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF282

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF282 Gene

Localization for ZNF282 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF282 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF282 Gene COMPARTMENTS Subcellular localization image for ZNF282 gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for ZNF282 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF282: view

Pathways for ZNF282 Gene

SuperPathways for ZNF282 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF282: view

Pathways by source for ZNF282 Gene

2 Reactome pathways for ZNF282 Gene

Interacting Proteins for ZNF282 Gene

Gene Ontology (GO) - Biological Process for ZNF282 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated TAS 9396811
GO:0045892 negative regulation of transcription, DNA-templated TAS 9396811
genes like me logo Genes that share ontologies with ZNF282: view

Transcripts for ZNF282 Gene

Unigene Clusters for ZNF282 Gene

Zinc finger protein 282:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF282

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF282 Gene

No ASD Table

Relevant External Links for ZNF282 Gene

GeneLoc Exon Structure for
ZNF282
ECgene alternative splicing isoforms for
ZNF282

Expression for ZNF282 Gene

mRNA expression in normal human tissues for ZNF282 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for ZNF282 Gene

This gene is overexpressed in Adipocyte (35.8) and Pancreatic juice (33.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for ZNF282 Gene

SOURCE GeneReport for Unigene cluster for ZNF282 Gene Hs.729056

mRNA Expression by UniProt/SwissProt for ZNF282 Gene

Q9UDV7-ZN282_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with ZNF282: view

Expression partners for ZNF282 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ZNF282 Gene

Orthologs for ZNF282 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF282 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF282 35
  • 87.96 (n)
  • 91.2 (a)
ZNF282 36
  • 68 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF282 35
  • 91.37 (n)
  • 94.1 (a)
ZNF282 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp282 35
  • 86.34 (n)
  • 89.83 (a)
Zfp282 16
Zfp282 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZNF282 35
  • 99.6 (n)
  • 99.85 (a)
ZNF282 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp282 35
  • 86.09 (n)
  • 88.47 (a)
oppossum
(Monodelphis domestica)
Mammalia ZNF282 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF282 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
  • 56 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia ZNF282 36
  • 45 (a)
OneToOne
Species with no ortholog for ZNF282:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF282 Gene

ENSEMBL:
Gene Tree for ZNF282 (if available)
TreeFam:
Gene Tree for ZNF282 (if available)

Paralogs for ZNF282 Gene

Paralogs for ZNF282 Gene

Selected SIMAP similar genes for ZNF282 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZNF282: view

Variants for ZNF282 Gene

Sequence variations from dbSNP and Humsavar for ZNF282 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs740130 -- 149,212,002(-) TTTTT(A/T)AAATT intron-variant
rs1006683 -- 149,209,344(+) cccac(A/G)agcag intron-variant
rs1123992 -- 149,210,109(+) ATCCC(C/G)GCTTC intron-variant
rs1202388 -- 149,216,366(+) aagct(C/T)tggga intron-variant
rs1202389 -- 149,216,553(+) AGCCT(G/T)CTTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF282 Gene

Variant ID Type Subtype PubMed ID
nsv889402 CNV Loss 21882294
nsv518773 CNV Loss 19592680
nsv465196 CNV Loss 19166990

Relevant External Links for ZNF282 Gene

HapMap Linkage Disequilibrium report
ZNF282

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF282 Gene

Disorders for ZNF282 Gene

Relevant External Links for ZNF282

Genetic Association Database (GAD)
ZNF282
Human Genome Epidemiology (HuGE) Navigator
ZNF282

No disorders were found for ZNF282 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for ZNF282 Gene

Publications for ZNF282 Gene

  1. HUB1, a novel Kruppel type zinc finger protein, represses the human T cell leukemia virus type I long terminal repeat-mediated expression. (PMID: 9396811) Okumura K. … Igarashi H. (Nucleic Acids Res. 1997) 2 3 4 23
  2. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. Comparative proteomic analysis identifies a role for SUMO in protein quality control. (PMID: 21693764) Tatham M.H. … Hay R.T. (Sci Signal 2011) 3

Products for ZNF282 Gene

Sources for ZNF282 Gene

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