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Aliases for ZNF282 Gene

Aliases for ZNF282 Gene

  • Zinc Finger Protein 282 2 3 5
  • HTLV-I U5RE-Binding Protein 1 3 4
  • HUB-1 3 4
  • HUB1 3 4
  • HTLV-I U5 Repressive Element-Binding Protein 1 3

External Ids for ZNF282 Gene

Previous GeneCards Identifiers for ZNF282 Gene

  • GC07P147139
  • GC07P148207
  • GC07P148284
  • GC07P148216
  • GC07P148330
  • GC07P148523
  • GC07P148892
  • GC07P142969

Summaries for ZNF282 Gene

GeneCards Summary for ZNF282 Gene

ZNF282 (Zinc Finger Protein 282) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF746.

UniProtKB/Swiss-Prot for ZNF282 Gene

  • Binds to the U5 repressive element (U5RE) of the human T cell leukemia virus type I long terminal repeat. It recognizes the 5-TCCACCCC-3 sequence as a core motif and exerts a strong repressive effect on HTLV-I LTR-mediated expression.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF282 Gene

Genomics for ZNF282 Gene

Regulatory Elements for ZNF282 Gene

Enhancers for ZNF282 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF282 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF282 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF282 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF282 Gene

Chromosome:
7
Start:
149,195,462 bp from pter
End:
149,226,248 bp from pter
Size:
30,787 bases
Orientation:
Plus strand

Genomic View for ZNF282 Gene

Genes around ZNF282 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF282 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF282 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF282 Gene

Proteins for ZNF282 Gene

  • Protein details for ZNF282 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UDV7-ZN282_HUMAN
    Recommended name:
    Zinc finger protein 282
    Protein Accession:
    Q9UDV7
    Secondary Accessions:
    • B4DRI5
    • O43691
    • Q6DKK0

    Protein attributes for ZNF282 Gene

    Size:
    671 amino acids
    Molecular mass:
    74295 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA24380.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF282 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF282 Gene

Proteomics data for ZNF282 Gene at MOPED

Post-translational modifications for ZNF282 Gene

  • Ubiquitination at Lys 228
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF282 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF282 Gene

Domains & Families for ZNF282 Gene

Gene Families for ZNF282 Gene

Protein Domains for ZNF282 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UDV7

UniProtKB/Swiss-Prot:

ZN282_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 5 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 5 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF282: view

Function for ZNF282 Gene

Molecular function for ZNF282 Gene

UniProtKB/Swiss-Prot Function:
Binds to the U5 repressive element (U5RE) of the human T cell leukemia virus type I long terminal repeat. It recognizes the 5-TCCACCCC-3 sequence as a core motif and exerts a strong repressive effect on HTLV-I LTR-mediated expression.
genes like me logo Genes that share phenotypes with ZNF282: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF282 Gene

Localization for ZNF282 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF282 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF282 Gene COMPARTMENTS Subcellular localization image for ZNF282 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF282 Gene

Pathways & Interactions for ZNF282 Gene

SuperPathways for ZNF282 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF282: view

Pathways by source for ZNF282 Gene

2 Reactome pathways for ZNF282 Gene

Interacting Proteins for ZNF282 Gene

Gene Ontology (GO) - Biological Process for ZNF282 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0045892 negative regulation of transcription, DNA-templated TAS 9396811
genes like me logo Genes that share ontologies with ZNF282: view

No data available for SIGNOR curated interactions for ZNF282 Gene

Drugs & Compounds for ZNF282 Gene

No Compound Related Data Available

Transcripts for ZNF282 Gene

Unigene Clusters for ZNF282 Gene

Zinc finger protein 282:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF282 Gene

No ASD Table

Relevant External Links for ZNF282 Gene

GeneLoc Exon Structure for
ZNF282
ECgene alternative splicing isoforms for
ZNF282

Expression for ZNF282 Gene

mRNA expression in normal human tissues for ZNF282 Gene

Protein differential expression in normal tissues from HIPED for ZNF282 Gene

This gene is overexpressed in Adipocyte (35.8) and Pancreatic juice (33.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF282 Gene



SOURCE GeneReport for Unigene cluster for ZNF282 Gene Hs.729056

mRNA Expression by UniProt/SwissProt for ZNF282 Gene

Q9UDV7-ZN282_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with ZNF282: view

Protein tissue co-expression partners for ZNF282 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZNF282 Gene

Orthologs for ZNF282 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF282 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF282 35
  • 87.96 (n)
  • 91.2 (a)
ZNF282 36
  • 68 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF282 35
  • 91.37 (n)
  • 94.1 (a)
ZNF282 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp282 35
  • 86.34 (n)
  • 89.83 (a)
Zfp282 16
Zfp282 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZNF282 35
  • 99.6 (n)
  • 99.85 (a)
ZNF282 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp282 35
  • 86.09 (n)
  • 88.47 (a)
oppossum
(Monodelphis domestica)
Mammalia ZNF282 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF282 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
  • 56 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia ZNF282 36
  • 45 (a)
OneToOne
Species with no ortholog for ZNF282:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF282 Gene

ENSEMBL:
Gene Tree for ZNF282 (if available)
TreeFam:
Gene Tree for ZNF282 (if available)

Paralogs for ZNF282 Gene

Paralogs for ZNF282 Gene

(321) SIMAP similar genes for ZNF282 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZNF282: view

Variants for ZNF282 Gene

Sequence variations from dbSNP and Humsavar for ZNF282 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1202418 - 149,207,455(+) TCCCA(A/G)TGGAT reference, missense
rs1006683 -- 149,209,344(+) cccac(A/G)agcag intron-variant
rs6949523 -- 149,207,630(+) TGGTG(A/G/T)TCACT intron-variant
rs1123992 -- 149,210,109(+) ATCCC(C/G/T)GCTTC intron-variant
rs1202388 -- 149,216,366(+) aagct(C/T)tggga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF282 Gene

Variant ID Type Subtype PubMed ID
nsv889402 CNV Loss 21882294
nsv518773 CNV Loss 19592680
nsv465196 CNV Loss 19166990

Variation tolerance for ZNF282 Gene

Residual Variation Intolerance Score: 10.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.93; 67.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF282 Gene

HapMap Linkage Disequilibrium report
ZNF282

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF282 Gene

Disorders for ZNF282 Gene

Relevant External Links for ZNF282

Genetic Association Database (GAD)
ZNF282
Human Genome Epidemiology (HuGE) Navigator
ZNF282
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF282

No disorders were found for ZNF282 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF282 Gene

Publications for ZNF282 Gene

  1. HUB1, a novel Kruppel type zinc finger protein, represses the human T cell leukemia virus type I long terminal repeat-mediated expression. (PMID: 9396811) Okumura K. … Igarashi H. (Nucleic Acids Res. 1997) 2 3 4 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. ZNF282 (Zinc finger protein 282), a novel E2F1 co-activator, promotes esophageal squamous cell carcinoma. (PMID: 25373738) Yeo S.Y. … Kim S.H. (Oncotarget 2014) 3
  4. SUMOylation of ZFP282 potentiates its positive effect on estrogen signaling in breast tumorigenesis. (PMID: 22986521) Yu E.J. … Kim J.H. (Oncogene 2013) 3
  5. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 3

Products for ZNF282 Gene

Sources for ZNF282 Gene

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