ZNF282 Gene
protein-coding GIFtS: 51
GCID: GC07P148892
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|
zinc finger protein 282
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Aliases for ZNF282 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 2821 2 | | HUB11 2 3 | | HUB-12 3 | | HTLV-I U5RE-Binding Protein 12 3 | | HTLV-I U5 Repressive Element-Binding Protein 12 |
Export aliases for ZNF282 gene to outside databasesPrevious GC identifers: GC07P147139 GC07P148207 GC07P148284 GC07P148216 GC07P148330 GC07P148523 GC07P142969 |
Summaries for ZNF282 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: ZN282_HUMAN, Q9UDV7Function: Binds to the U5 repressive element (U5RE) of the human T cell leukemia virus type I long terminal repeat. Itrecognizes the 5'-TCCACCCC-3' sequence as a core motif and exerts a strong repressive effect on HTLV-I LTR-mediatedexpression
|
Genomic Views for ZNF282 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007914.15 NT_079596.2
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ZNF282 gene promoter: Max1 AML1a NRSF form 1 Olf-1 Ik-3 NRSF form 2 AREB6 Pax-4a c-Myc Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF282
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF282 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q36.1 Ensembl cytogenetic band: 7q36.1 HGNC cytogenetic band: 7q36.1ZNF282 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P148892: view genomic region
(about GC identifiers)
Start:
|
148,892,577 bp from pter |
End:
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148,923,339 bp from pter |
Size:
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30,763 bases |
Orientation:
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plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 148,230,571-148,261,360 |
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Proteins for ZNF282 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: ZN282_HUMAN, Q9UDV7 (See
protein sequence)Recommended Name: Zinc finger protein 282 Size: 671 amino acids; 74295 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=BAA24380.1; Type=Erroneous initiation;
Secondary accessions: O43691 Q6DKK0Explore the universe of human proteins at neXtProt for ZNF282: NX_Q9UDV7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UDV7 ZNF282 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003566.1 ENSEMBL proteins: ENSP00000262085 ENSP00000418840 Reactome Protein details: Q9UDV7 Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZNF282 for ontologies About GeneDecksing
ZNF282 Antibody Products: Assay Products for ZNF282: |
Protein
Domains / Families for ZNF282 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF282 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UDV7ProtoNet protein and cluster: Q9UDV7 1 Blocks protein family: IPB001909 KRAB box
UniProtKB/Swiss-Prot: ZN282_HUMAN, Q9UDV7Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 5 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function for ZNF282 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: ZN282_HUMAN, Q9UDV7Function: Binds to the U5 repressive element (U5RE) of the human T cell leukemia virus type I long terminal repeat. Itrecognizes the 5'-TCCACCCC-3' sequence as a core motif and exerts a strong repressive effect on HTLV-I LTR-mediatedexpression
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF282 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF282 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZNF282 (NM_003575) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF282 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF282  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF282 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZNF282 for ontologies About GeneDecksing
|
Pathways & Interactions for ZNF282 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources See GeneCards unified pathways Show all pathways
2
Reactome Pathways for ZNF282
ZNF282 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF282
STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)
 5/7 Interacting proteins for ZNF282 (Q9UDV72, 3 ENSP000002620854) via UniProtKB, MINT, STRING, and/or I2D (see all 7)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
TAS | 9396811 | | GO:0045892 | negative regulation of transcription, DNA-dependent |
TAS | 9396811 |
ZNF282 for ontologies About GeneDecksing
|
Drugs & Compounds for ZNF282 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for ZNF282 Search CenterWatch for drugs/clinical trials and news about ZNF282 / ZN282 
|
Transcripts for ZNF282 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for ZNF282 gene: NM_003575.2 Unigene Cluster for ZNF282: Zinc finger protein 282 Hs.729056 [show with all ESTs]Unigene Representative Sequence: D306124 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000262085(uc011kun.1 uc003wfm.3 uc003wfo.3) ENST00000479907(uc003wfn.3) ENST00000462740 ENST00000470381
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF282 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF282 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZNF282 (NM_003575) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF282 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF282  |
Additional cDNA sequence: AK299280.1 AK316282.1 AY927503.1 AY927504.1 AY927505.1 BC009542.1 BC031686.1 BC041704.1 BC055287.1 BC073805.1 D30612.1 10 DOTS entries: DT.315221 DT.97767626 DT.99935364 DT.100785637 DT.100785631 DT.91938236 DT.95112929 DT.100785633 DT.40131852 DT.99993835 24/155 AceView cDNA sequences (see all 155): AI818124 CR622305 BU736491 AI184874 BQ421181 BC009542 BM692587 AI634482 BM553048 BI255957 AA676828 BX281429 AU119822 BQ445937 AI569706 BC055287 AA476663 AW081864 BI964231 AI373372 CR615805 BC073805 BM052904 BC041704 GeneLoc Exon Structure
|
Expression for ZNF282 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF282 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: TTCACAGAGC
About this image See ZNF282 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ZNF282
SOURCE GeneReport for Unigene cluster: Hs.729056 UniProtKB/Swiss-Prot: ZN282_HUMAN, Q9UDV7Tissue specificity: Ubiquitous SABiosciences Custom PCR Arrays for ZNF282
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF282 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNF282 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF282 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF282 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF282 |
Orthologs for ZNF282 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZNF282 gene from 1/8 species (see all 8) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
lizard (Anolis carolinensis) |
Reptilia |
ZNF2826 |
-- |
53(a) |
1 ↔ 1 |
GL343332.1(1103615-1109661) |
ENSEMBL Gene Tree for ZNF282 (if available) TreeFam Gene Tree for ZNF282 (if available)  |
Paralogs for ZNF282 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for ZNF282 gene
- ZNF7772 ZNF7462 ZNF2122 ZNF3982 ZNF7832
18/320 SIMAP similar genes for ZNF282 using alignment to 4 protein entries: ZN282_HUMAN (see all proteins)
(see all similar genes):ZNF767 LOC155060 ZNF211 ZNF84 DKFZp666M039 ZNF26 ZNF586 ZNF79 ZNF283 HZF36 ZNF189 ZNF260 ZNF286A ZNF286B ZNF300 ZNF420 ZNF485 ZNF577
ZNF282 for paralogs About GeneDecksing
|
Genomic Variants for ZNF282 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 7 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF282 (148892577 - 148923339 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for ZNF282: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF282 |
|
Disorders
/ Diseases for ZNF282 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF282 for disorders About GeneDecksing
OMIM gene information: 603397
OMIM disorders: --
3 diseases for ZNF282: About MalaCardsadult t-cell leukemia t-cell leukemia leukemia Human Genome Epidemiology (HuGE) Navigator: ZNF282 (1 document) Export disorders for ZNF282 gene to outside databases
|
Publications for ZNF282 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF282 gene, integrated from 9 sources (see all 14): (articles sorted by number of sources associating them with ZNF282) | |  | Utopia: connect your pdf to the dynamic world of online information |
- HUB1, a novel Kruppel type zinc finger protein, represses the human T cell leukemia virus type I long terminal repeat-mediated expression. (PubMed id 9396811)1, 2, 3, 9 Okumura K.... Igarashi H. (1997)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Comparative proteomic analysis identifies a role for S UMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (2011)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution. (PubMed id 15790807)1 Cheng J....Gingeras T.R. (2005)
- Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1 Scherer S.W.... Tsui L.-C. (2003)
|
External Searches for ZNF282 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing ZNF282 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF282 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF282 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for ZNF282 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF282 gene: Search GeneIP for patents involving ZNF282
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for ZNF282 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
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 | |
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| | | | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF282 | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF282 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF282 | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for ZNF282 | | OriGene 3'-UTR Clone for ZNF282 | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF282 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF282 | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | OriGene Custom Antibody Services for ZNF282 | | OriGene Custom Protein Services for ZNF282 | | OriGene Custom Immunoassay Development | | |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF282 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF282 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF282 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF282 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF282 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF282 |
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| | | Search Tocris compounds for ZNF282 |
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 | | ZNF282 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF282 |
|  |  |  | | | Search ThermoFisher Antibodies for ZNF282 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF282 |
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