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Aliases for ZNF281 Gene

Aliases for ZNF281 Gene

  • Zinc Finger Protein 281 2 3 5
  • GC-Box-Binding Zinc Finger Protein 1 3 4
  • Zinc Finger DNA-Binding Protein 99 3 4
  • Transcription Factor ZBP-99 3 4
  • ZNP-99 Transcription Factor 3
  • ZBP-99 3
  • ZNP-99 3
  • ZBP99 4
  • GZP1 4

External Ids for ZNF281 Gene

Previous GeneCards Identifiers for ZNF281 Gene

  • GC01M198105
  • GC01M195834
  • GC01M196842
  • GC01M197664
  • GC01M197663
  • GC01M197107
  • GC01M198642
  • GC01M200375
  • GC01M171541

Summaries for ZNF281 Gene

GeneCards Summary for ZNF281 Gene

ZNF281 (Zinc Finger Protein 281) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is ZNF740.

UniProtKB/Swiss-Prot for ZNF281 Gene

  • Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs (By similarity). Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G-rich box in the enhancer region of these genes.

Gene Wiki entry for ZNF281 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF281 Gene

Genomics for ZNF281 Gene

Regulatory Elements for ZNF281 Gene

Enhancers for ZNF281 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF281 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF281 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF281 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF281 Gene

Chromosome:
1
Start:
200,404,940 bp from pter
End:
200,410,058 bp from pter
Size:
5,119 bases
Orientation:
Minus strand

Genomic View for ZNF281 Gene

Genes around ZNF281 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF281 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF281 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF281 Gene

Proteins for ZNF281 Gene

  • Protein details for ZNF281 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2X9-ZN281_HUMAN
    Recommended name:
    Zinc finger protein 281
    Protein Accession:
    Q9Y2X9
    Secondary Accessions:
    • A6NF48
    • B3KMX2
    • Q5RKW5
    • Q9NY92

    Protein attributes for ZNF281 Gene

    Size:
    895 amino acids
    Molecular mass:
    96915 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAB70967.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF281 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF281 Gene

Proteomics data for ZNF281 Gene at MOPED

Post-translational modifications for ZNF281 Gene

  • Ubiquitination at Lys 539, Lys 661, and Lys 840
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF281 Gene

Antibody Products

No data available for DME Specific Peptides for ZNF281 Gene

Domains & Families for ZNF281 Gene

Gene Families for ZNF281 Gene

Protein Domains for ZNF281 Gene

Suggested Antigen Peptide Sequences for ZNF281 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y2X9

UniProtKB/Swiss-Prot:

ZN281_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 4 C2H2-type zinc fingers.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 4 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF281: view

Function for ZNF281 Gene

Molecular function for ZNF281 Gene

GENATLAS Biochemistry:
zinc finger protein 281,regulating ornithine decarboxylase gene (ODC) expression,major transcript,highly expressed in placenta,adult kidney,liver,lymphocytes,binding to thhe GC rich promoter element of gastrin and ODC
UniProtKB/Swiss-Prot Function:
Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs (By similarity). Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G-rich box in the enhancer region of these genes.

Gene Ontology (GO) - Molecular Function for ZNF281 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 10448078
GO:0003700 transcription factor activity, sequence-specific DNA binding IDA 10448078
GO:0005515 protein binding IPI 17314511
GO:0044212 transcription regulatory region DNA binding IDA 10448078
genes like me logo Genes that share ontologies with ZNF281: view
genes like me logo Genes that share phenotypes with ZNF281: view

Animal Models for ZNF281 Gene

MGI Knock Outs for ZNF281:

Animal Model Products

CRISPR Products

miRNA for ZNF281 Gene

miRTarBase miRNAs that target ZNF281

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF281 Gene

Localization for ZNF281 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF281 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF281 Gene COMPARTMENTS Subcellular localization image for ZNF281 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for ZNF281 Gene

Pathways & Interactions for ZNF281 Gene

SuperPathways for ZNF281 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF281 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010172 embryonic body morphogenesis ISS --
GO:0045893 positive regulation of transcription, DNA-templated IDA 10405178
genes like me logo Genes that share ontologies with ZNF281: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF281 Gene

Drugs & Compounds for ZNF281 Gene

No Compound Related Data Available

Transcripts for ZNF281 Gene

Unigene Clusters for ZNF281 Gene

Zinc finger protein 281:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF281 Gene

No ASD Table

Relevant External Links for ZNF281 Gene

GeneLoc Exon Structure for
ZNF281
ECgene alternative splicing isoforms for
ZNF281

Expression for ZNF281 Gene

mRNA expression in normal human tissues for ZNF281 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF281 Gene

This gene is overexpressed in Brain (64.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF281 Gene



SOURCE GeneReport for Unigene cluster for ZNF281 Gene Hs.59757

genes like me logo Genes that share expression patterns with ZNF281: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZNF281 Gene

Orthologs for ZNF281 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF281 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF281 35
  • 89.09 (n)
  • 93.01 (a)
ZNF281 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF281 35
  • 91.45 (n)
  • 94.63 (a)
mouse
(Mus musculus)
Mammalia Zfp281 35
  • 94.35 (n)
  • 95.91 (a)
Zfp281 16
Zfp281 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZNF281 35
  • 99.77 (n)
  • 99.77 (a)
ZNF281 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp281 35
  • 93.61 (n)
  • 96.5 (a)
oppossum
(Monodelphis domestica)
Mammalia ZNF281 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF281 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF281 35
  • 83.11 (n)
  • 83.95 (a)
ZNF281 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF281 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znf281 35
  • 67.38 (n)
  • 60.68 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.30049 35
zebrafish
(Danio rerio)
Actinopterygii LOC100005963 35
  • 57.59 (n)
  • 51.79 (a)
ZNF281 (1 of 2) 36
  • 36 (a)
OneToMany
ZNF281 (2 of 2) 36
  • 39 (a)
OneToMany
Species with no ortholog for ZNF281:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF281 Gene

ENSEMBL:
Gene Tree for ZNF281 (if available)
TreeFam:
Gene Tree for ZNF281 (if available)

Paralogs for ZNF281 Gene

Paralogs for ZNF281 Gene

genes like me logo Genes that share paralogs with ZNF281: view

Variants for ZNF281 Gene

Sequence variations from dbSNP and Humsavar for ZNF281 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_035576 A breast cancer sample
rs1128817 -- 200,406,081(-) TGTTA(C/T)GTATT utr-variant-3-prime
rs3204322 -- 200,406,718(-) AAAGA(A/C/T)AAAAA utr-variant-3-prime
rs3210270 -- 200,406,720(-) AAAAA(A/G)ACAAA utr-variant-3-prime
rs4244146 -- 200,411,186(+) GCTTA(C/T)TTACA upstream-variant-2KB

Variation tolerance for ZNF281 Gene

Residual Variation Intolerance Score: 16.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.50; 29.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF281 Gene

HapMap Linkage Disequilibrium report
ZNF281

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZNF281 Gene

Disorders for ZNF281 Gene

Relevant External Links for ZNF281

Genetic Association Database (GAD)
ZNF281
Human Genome Epidemiology (HuGE) Navigator
ZNF281
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF281

No disorders were found for ZNF281 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF281 Gene

Publications for ZNF281 Gene

  1. ZBP-99 defines a conserved family of transcription factors and regulates ornithine decarboxylase gene expression. (PMID: 10448078) Law D.J. … Merchant J.L. (Biochem. Biophys. Res. Commun. 1999) 2 3 4 23 67
  2. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. A systems-wide screen identifies substrates of the SCFI^TrCP ubiquitin ligase. (PMID: 25515538) Low T.Y. … Heck A.J. (Sci Signal 2014) 3

Products for ZNF281 Gene

Sources for ZNF281 Gene

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