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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF281 Gene

protein-coding   GIFtS: 50
GCID: GC01M200375

Zinc Finger Protein 281

  Search for ZNF281
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 2811 2     ZNP-992
Transcription Factor ZBP-992 3     ZNP-99 Transcription Factor2
Zinc Finger DNA-Binding Protein 992 3     GZP13
GC-Box-Binding Zinc Finger Protein 12 3     ZBP993
ZBP-992     

External Ids:    HGNC: 130751   Entrez Gene: 235282   Ensembl: ENSG000001627027   UniProtKB: Q9Y2X93   

Export aliases for ZNF281 gene to outside databases

Previous GC identifers: GC01M198105 GC01M195834 GC01M196842 GC01M197664 GC01M197663 GC01M197107 GC01M198642 GC01M171541


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF281 Gene: 
ZNF281 (zinc finger protein 281) is a protein-coding gene. GO annotations related to this gene include transcription corepressor activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZNF148.

UniProtKB/Swiss-Prot: ZN281_HUMAN, Q9Y2X9
Function: Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation.
Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG
promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which
deacetylates histones. Not required for establishement and maintenance of ESCs (By similarity). Represses the
transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G-rich box in the enhancer region
of these genes

Gene Wiki entry for ZNF281 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF281 gene promoter:
         Max1   Lmo2   STAT5A   Nkx2-5   C/EBPalpha   FOXJ2 (long isoform)   FOXJ2   Pax-4a   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF281 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF281

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF281


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.1   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32.1

ZNF281 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF281 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M200375:  view genomic region     (about GC identifiers)

Start:
200,375,420 bp from pter      End:
200,379,184 bp from pter
Size:
3,765 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN281_HUMAN, Q9Y2X9 (See protein sequence)
Recommended Name: Zinc finger protein 281  
Size: 895 amino acids; 96915 Da
Subcellular location: Nucleus
Sequence caution: Sequence=CAB70967.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B3KMX2 Q5RKW5 Q9NY92

Explore the universe of human proteins at neXtProt for ZNF281: NX_Q9Y2X9

Explore proteomics data for ZNF281 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y2X9

  • ZNF281 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF281 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001268222.1  NP_001268223.1  NP_036614.1  

    ENSEMBL proteins: 
     ENSP00000294740   ENSP00000356322   ENSP00000356321  

    Human Recombinant Protein Products for ZNF281: 
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    Novus Biologicals ZNF281 Proteins
    Novus Biologicals ZNF281 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZNF281 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--

    ZNF281 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9Y2X9

    ProtoNet protein and cluster: Q9Y2X9

    UniProtKB/Swiss-Prot: ZN281_HUMAN, Q9Y2X9
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 4 C2H2-type zinc fingers


    ZNF281 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN281_HUMAN, Q9Y2X9
    Function: Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation.
    Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG
    promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which
    deacetylates histones. Not required for establishement and maintenance of ESCs (By similarity). Represses the
    transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G-rich box in the enhancer region
    of these genes

         Genatlas biochemistry entry for ZNF281:
    zinc finger protein 281,regulating ornithine decarboxylase gene (ODC) expression,major transcript,highly expressed
    in placenta,adult kidney,liver,lymphocytes,binding to thhe GC rich promoter element of gastrin and ODC

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001047core promoter binding ISS--
    GO:0003676nucleic acid binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IDA10448078
    GO:0003714transcription corepressor activity ISS--
    GO:0005515protein binding IPI17314511
         
    ZNF281 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Zfp281):
     cellular  mortality/aging 

    ZNF281 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Zfp281tm1.1Jlwa for ZNF281

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZNF281 
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    SwitchGear 3'UTR luciferase reporter plasmidZNF281 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF281

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/25 Interacting proteins for ZNF281 (Q9Y2X92, 3 ENSP000002947404) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000235068Q018603, ENSP000004050414I2D: score=1 STRING: ENSP00000405041
    ENSG00000206454Q018603I2D: score=1 
    ENSG00000229094Q018603I2D: score=1 
    ENSG00000230336Q018603I2D: score=1 
    ENSG00000233911Q018603I2D: score=1 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0010172embryonic body morphogenesis ISS--
    GO:0010629negative regulation of gene expression IMP10448078
    GO:0045892negative regulation of transcription, DNA-dependent IMP10448078
    GO:0045893positive regulation of transcription, DNA-dependent IDA10405178

    ZNF281 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF281 (ZN281)

    Search CenterWatch for drugs/clinical trials and news about ZNF281 / ZN281

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF281 gene (3 alternative transcripts): 
    NM_001281293.1  NM_001281294.1  NM_012482.4  

    Unigene Clusters for ZNF281:

    Zinc finger protein 281
    Hs.59757  [show with all ESTs], Hs.735801  [show with all ESTs]
    Unigene Representative Sequences: BC060820, AK094701
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000294740(uc001gve.3 uc001gvf.1 uc001gvg.1) ENST00000367353
    ENST00000367352
    miRNA
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    hsa-miR-3607-3p hsa-miR-3938 hsa-miR-188-5p hsa-miR-488 hsa-miR-500a hsa-miR-449a hsa-miR-374c hsa-miR-4273
    SwitchGear 3'UTR luciferase reporter plasmidZNF281 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF281
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    Additional mRNA sequence: AK094701.1 

    7 DOTS entries:

    DT.100679410  DT.121358231  DT.97826836  DT.92409476  DT.121358230  DT.121358074  DT.303929 

    24/141 AceView cDNA sequences (see all 141):

    AI086548 AK021707 AI628629 BX282281 BM699340 AI224110 CK904298 BQ010225 
    BE464532 AI803645 BM558244 AF086540 BE349011 AU122253 AI474217 BI496066 
    AI493984 AA297293 W96111 BC060820 AI334384 AK022916 R32251 AA908978 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF281 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATAGATCGT
    ZNF281 Expression
    About this image


    See ZNF281 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF281

    SOURCE GeneReport for Unigene clusters: Hs.59757 Hs.735801
        SABiosciences Custom PCR Arrays for ZNF281
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF281 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp2811 , 5 zinc finger protein 2811, 5 93.98(n)1
    95.07(a)1
      1 (59.93 cM)5
    2264421  NM_001160251.11  NP_001153723.11 
     1366249015 
    chicken
    (Gallus gallus)
    Aves LOC1008597001 zinc finger protein 281-like 80.93(n)
    81.64(a)
      100859700  XM_003641665.1  XP_003641713.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZNF2816
    Uncharacterized protein
    71(a)
    1 ↔ 1
    GL343211.1(1731511-1734147)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.300492 Xenopus laevis transcribed sequence with weak similarity more 78.66(n)    CA986921.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1130261 zgc:113026 56.57(n)
    51.7(a)
      503523  NM_001012487.2  NP_001012505.2 


    ENSEMBL Gene Tree for ZNF281 (if available)
    TreeFam Gene Tree for ZNF281 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF281 gene
    ZNF1482  ZNF4672  ZNF7402  
    18/41 SIMAP similar genes for ZNF281 using alignment to 2 protein entries:     ZN281_HUMAN (see all proteins) (see all similar genes):
    ZNF78L1    kr-znf3    HZF36    ZNF22    zf30    ZNF148
    ZNF    smap-7    A-328A3.4    DKFZp666C237    DKFZp686N0199    ZNF138
    ZNF697    ZNF844    DKFZp686M04222    DKFZp686O1631    HZF40    ZSCAN21

    ZNF281 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/154 SNPs in ZNF281 are shown (see all 154)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0355764
    A breast cancer sample4--see VAR_0355762 I T mis40--------
    rs106665911,2
    C--200375004(+) TTTTT-/T/TT  
            
    AAAGG
    1 -- int11NA 2
    rs1870938921,2
    --200375004(+) TTTTTA/TAAAGG 1 -- int10--------
    rs11288171,2
    C,F,O,A,H--200375209(-) TGTTAC/TGTATT 1 -- int127Minor allele frequency- T:0.27NA EA MN NS WA 2846
    rs796174531,2
    F--200375359(+) GAATCA/GCTTGA 1 -- int10--------
    rs783607441,2
    C--200375442(+) TCATTC/GCAGGC 1 -- ut310--------
    rs1922650351,2
    --200375584(+) GGAGAC/TAGCAA 1 -- ut310--------
    rs1850516221,2
    --200375717(+) GGATAC/TTCCAT 1 -- ut310--------
    rs1906931691,2
    --200375734(+) GATAAC/TGTACA 1 -- ut310--------
    rs357539591,2
    C--200375763(+) ACACTT/GTCCTG 1 -- ut311Minor allele frequency- G:0.00NA 2

    HapMap Linkage Disequilibrium report for ZNF281 (200375420 - 200379184 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ZNF281: --
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZNF281 for disorders           About MalaCards

    ZNF281 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZNF281
    Human Genome Epidemiology (HuGE) Navigator: ZNF281 (1 document)

    Export disorders for ZNF281 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF281 gene, integrated from 9 sources (see all 37):
    (articles sorted by number of sources associating them with ZNF281)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ZBP-99 defines a conserved family of transcription factors and regulates ornithine decarboxylase gene expression. (PubMed id 10448078)1, 2, 3, 9 Law D.J.... Merchant J.L. (1999)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. ZBP-89 represses vimentin gene transcription by interacting with the transcriptional activator, Sp1. (PubMed id 12771217)1, 2 Zhang X....Zehner Z.E. (2003)
    5. Identification of human GC-box-binding zinc finger protein, a new Krueppel-like zinc finger protein, by the yeast one-hybrid screening with a GC-rich target sequence. (PubMed id 10405178)1, 2 Lisowsky T.... Cantatore P. (1999)
    6. A strategy for modulation of enzymes in the ubiquitin system. (PubMed id 23287719)1 Ernst A.... Sidhu S.S. (2013)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. (PubMed id 22678362)1 Stehling O....Lill R. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23528 HGNC: 13075 AceView: ZNF281 Ensembl:ENSG00000162702 euGenes: HUgn23528
    ECgene: ZNF281 H-InvDB: ZNF281

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF281 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF281 gene:
    Search GeneIP for patents involving ZNF281

    GeneCards and IP:
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