ZNF281 Gene
protein-coding GIFtS: 48
GCID: GC01M200375
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zinc finger protein 281
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Aliases
for ZNF281 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 2811 2 | | ZNP-992 | | ZBP-991 2 | | ZNP-99 Transcription Factor2 | | Transcription Factor ZBP-992 3 | | GZP13 | | Zinc Finger DNA-Binding Protein 992 3 | | ZBP993 | | GC-Box-Binding Zinc Finger Protein 12 3 | | |
Export aliases for ZNF281 gene to outside databasesPrevious GC identifers: GC01M198105 GC01M195834 GC01M196842 GC01M197664 GC01M197663 GC01M197107 GC01M198642 GC01M171541 |
Summaries
for ZNF281 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN281_HUMAN, Q9Y2X9Function: Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation.Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoterand promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylateshistones. Not required for establishement and maintenance of ESCs (By similarity). Represses the transcription of anumber of genes including GAST, ODC1 and VIM. Binds to the G-rich box in the enhancer region of these genes
Gene Wiki entry for ZNF281
|
Genomic Views
for ZNF281 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF281 gene promoter:
Max1 Lmo2 STAT5A Nkx2-5 C/EBPalpha FOXJ2 (long isoform) FOXJ2 Pax-4a c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF281
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF281 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q32.1 Ensembl cytogenetic band: 1q32.1 HGNC cytogenetic band: 1q32.1ZNF281 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M200375: view genomic region
(about GC identifiers)
Start:
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200,375,420 bp from pter |
End:
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200,379,184 bp from pter |
Size:
|
3,765 bases |
Orientation:
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minus strand |
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Proteins
for ZNF281 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN281_HUMAN, Q9Y2X9 (See
protein sequence)Recommended Name: Zinc finger protein 281 Size: 895 amino acids; 96915 Da
Subcellular location: Nucleus
Sequence caution: Sequence=CAB70967.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B3KMX2 Q5RKW5 Q9NY92Explore the universe of human proteins at neXtProt for ZNF281: NX_Q9Y2X9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y2X9
ZNF281 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_036614.1
ENSEMBL proteins: ENSP00000294740 ENSP00000356322 ENSP00000356321
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
ZNF281 for ontologies About GeneDecksing
ZNF281 Antibody Products:
Assay Products for ZNF281: |
Protein
Domains /
Families
for ZNF281 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF281 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9Y2X9ProtoNet protein and cluster: Q9Y2X9 UniProtKB/Swiss-Prot: ZN281_HUMAN, Q9Y2X9Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 4 C2H2-type zinc fingers |
Function
for ZNF281 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZN281_HUMAN, Q9Y2X9Function: Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation.Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoterand promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylateshistones. Not required for establishement and maintenance of ESCs (By similarity). Represses the transcription of anumber of genes including GAST, ODC1 and VIM. Binds to the G-rich box in the enhancer region of these genes Genatlas biochemistry entry for ZNF281:zinc finger protein 281,regulating ornithine decarboxylase gene (ODC) expression,major transcript,highly expressed inplacenta,adult kidney,liver,lymphocytes,binding to thhe GC rich promoter element of gastrin and ODC
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF281
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF281 |
Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table
ZNF281 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Zfp281tm1.1Jlwa for ZNF281
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Zfp281):
ZNF281 for phenotypes About GeneDecksing
|
Pathways & Interactions
for ZNF281 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF281
STRING Interaction
Network Preview (showing 5 interactants - click image to see 18)
5/20 Interacting proteins for ZNF281 (Q9Y2X92, 3 ENSP000002947404) via UniProtKB, MINT, STRING, and/or I2D (see all 20)About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table
ZNF281 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF281 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF281
Search CenterWatch for drugs/clinical trials and news about ZNF281 / ZN281
|
Transcripts
for ZNF281 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF281 gene: NM_012482.3 Unigene Clusters for ZNF281: Zinc finger protein 281 Hs.59757 [show with all ESTs], Hs.735801 [show with all ESTs]Unigene Representative Sequences: BC060820, AK0947013 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000294740(uc001gve.3 uc001gvf.1 uc001gvg.1) ENST00000367353
ENST00000367352
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF281 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF281
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF281 (NM_012482) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF281 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF281 |
Additional cDNA sequence: AK094701.1 7 DOTS entries: DT.100679410 DT.121358231 DT.97826836 DT.92409476 DT.121358230 DT.121358074 DT.303929 24/141 AceView cDNA sequences (see all 141): BX282281 BC060820 AA908978 BI496066 AK022916 BQ010225 BE218621 R32251 AA297293 AI334384 AI369724 BM558244 AI634880 AU122253 BE464532 NM_012482 BM021463 AA512896 AI474217 W96111 AU118807 CK904298 AI224110 AI086548
GeneLoc Exon Structure
|
Expression
for ZNF281 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF281 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATAGATCGT
About this image
See ZNF281 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF281
SOURCE GeneReport for Unigene clusters: Hs.59757 Hs.735801
SABiosciences Custom PCR Arrays for ZNF281
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF281
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF281 |
Orthologs
for ZNF281 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZNF281 gene from 4/12 species (see all 12) About this table
ENSEMBL Gene Tree for ZNF281 (if available)
TreeFam Gene Tree for ZNF281 (if available) |
Paralogs
for ZNF281 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF281 gene
- ZNF1482 ZNF7402
18/41 SIMAP similar genes for ZNF281 using alignment to 2 protein entries: ZN281_HUMAN (see all proteins)
(see all similar genes):ZNF78L1 kr-znf3 HZF36 ZNF22 zf30 ZNF148
ZNF smap-7 A-328A3.4 DKFZp666C237 DKFZp686N0199 ZNF138
ZNF697 ZNF844 DKFZp686M04222 DKFZp686O1631 HZF40 ZSCAN21
ZNF281 for paralogs About GeneDecksing
|
Genomic Variants
for ZNF281 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF281 (200375420 - 200379184 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF281: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF281 |
|
Disorders
/ Diseases
for ZNF281 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 ZNF281 for disorders About MalaCards
ZNF281 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: ZNF281 (1 document)
Export disorders for ZNF281 gene to outside databases
|
Publications
for ZNF281 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF281 gene, integrated from 9 sources (see all 29):
(articles sorted by number of sources associating them with ZNF281) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- ZBP-99 defines a conserved family of transcription factors and regulates ornithine decarboxylase gene expression. (PubMed id 10448078)1, 2, 3, 9 Law D.J.... Merchant J.L. (1999)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- ZBP-89 represses vimentin gene transcription by interacting with the transcriptional activator, Sp1. (PubMed id 12771217)1, 2 Zhang X....Zehner Z.E. (2003)
- Identification of human GC-box-binding zinc finger protein, a new Krueppel-like zinc finger protein, by the yeast one-hybrid screening with a GC-rich target sequence. (PubMed id 10405178)1, 2 Lisowsky T.... Cantatore P. (1999)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
|
External Searches for ZNF281 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF281 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF281 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF281 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF281 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF281 gene:
Search GeneIP for patents involving ZNF281
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF281 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | ZNF281 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF281 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF281 |
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