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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF280C Gene

protein-coding   GIFtS: 43
GCID: GC0XM129336

Zinc Finger Protein 280C

(Previous name: suppressor of hairy wing homolog 3 (Drosophila))
(Previous symbol: SUHW3)
  Search for ZNF280C
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 280C1 2
SUHW31 2 3
Suppressor Of Hairy Wing Homolog 32 3
Zinc Finger Protein 6332 3
ZNF6332 3
Suppressor Of Hairy Wing Homolog 3 (Drosophila)1

External Ids:    HGNC: 259551   Entrez Gene: 556092   Ensembl: ENSG000000562777   UniProtKB: Q8ND823   

Export aliases for ZNF280C gene to outside databases

Previous GC identifers: GC0XM129166 GC0XM118731


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ZNF280C Gene:
This gene encodes a member of the zinc finger domain-containing protein family. This family member contains
multiple Cys2-His2(C2H2)-type zinc finger domains, the most common type of zinc finger domain that self-folds to
form a beta-beta-alpha structure that binds a zinc ion. (provided by RefSeq, Aug 2011)

GeneCards Summary for ZNF280C Gene: 
ZNF280C (zinc finger protein 280C) is a protein-coding gene. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF280A.

UniProtKB/Swiss-Prot: Z280C_HUMAN, Q8ND82
Function: May function as a transcription factor




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.2  NT_011786.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF280C gene promoter:
         Pbx1a   Brachyury   Meis-1a   Pax-4a   TGIF   YY1   Meis-1   Meis-1b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF280C promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF280C

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF280C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq26.1   Ensembl cytogenetic band:  Xq26.1   HGNC cytogenetic band: Xq25

ZNF280C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF280C gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM129336:  view genomic region     (about GC identifiers)

Start:
129,336,673 bp from pter      End:
129,402,922 bp from pter
Size:
66,250 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: Z280C_HUMAN, Q8ND82 (See protein sequence)
Recommended Name: Zinc finger protein 280C  
Size: 737 amino acids; 83096 Da
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=BAA90947.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence;
Secondary accessions: A8K2V8 Q9NXR3

Explore the universe of human proteins at neXtProt for ZNF280C: NX_Q8ND82

Explore proteomics data for ZNF280C at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8ND82

  • ZNF280C Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF280C Protein Expression
    REFSEQ proteins: NP_060136.1  
    ENSEMBL proteins: 
     ENSP00000360017   ENSP00000408521  

    Human Recombinant Protein Products for ZNF280C: 
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZNF280C 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    ZNF280C for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR025243 DUF4195
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q8ND82

    ProtoNet protein and cluster: Q8ND82

    UniProtKB/Swiss-Prot: Z280C_HUMAN, Q8ND82
    Similarity: Contains 5 C2H2-type zinc fingers


    ZNF280C for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: Z280C_HUMAN, Q8ND82
    Function: May function as a transcription factor

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF280C for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZNF280C 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZNF280C 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZNF280C 

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidZNF280C 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF280C


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF280C

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for ZNF280C (ENSP000003600174) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SUMO2ENSP000004059654STRING: ENSP00000405965
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF280C for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF280C (Z280C)

    Search CenterWatch for drugs/clinical trials and news about ZNF280C / Z280C

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF280C gene: 
    NM_017666.4  

    Unigene Cluster for ZNF280C:

    Zinc finger protein 280C
    Hs.308418  [show with all ESTs]
    Unigene Representative Sequence: BC051728
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370978(uc004evm.3 uc010nrf.2) ENST00000447817
    miRNA
    Products:
         
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    8/78 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNF280C (see all 78):
    hsa-miR-411* hsa-miR-128 hsa-miR-3653 hsa-miR-519a hsa-miR-342-3p hsa-miR-3916 hsa-miR-1243 hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmidZNF280C 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF280C
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF280C
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF280C

    Additional mRNA sequence: 

    AK000102.1 AK290373.1 AL133204.1 AL834333.1 BC051728.1 

    3 DOTS entries:

    DT.91753790  DT.95268359  DT.100747155 

    24/35 AceView cDNA sequences (see all 35):

    BE139550 CR603297 AI681269 AI923562 BE501625 AL133204 AA773325 AA805654 
    BX474223 BX092851 BM456831 AL600988 CA306758 BG718445 BG719141 AW611940 
    BC051728 BX413265 AW408489 BX441545 AL834333 BX481708 BX952878 NM_017666 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF280C    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
    SP1:                                                                                                                  
    SP2:                                                                          -                                       


    ECgene alternative splicing isoforms for ZNF280C

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF280C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCTGTCTTG
    ZNF280C Expression
    About this image


    See ZNF280C Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF280C

    SOURCE GeneReport for Unigene cluster: Hs.308418
        SABiosciences Custom PCR Arrays for ZNF280C
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF280C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ZNF280C gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves --
    --
    41(a)
    1 → many
    10(7094684-7137592)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    35(a)
    1 → many
    GL343573.1(438826-450503)
    fruit fly
    (Drosophila melanogaster)
    Insecta row6
    relative of woc
    10(a)
    1 → many
    2R(11094032-11101137)
    worm
    (Caenorhabditis elegans)
    Secernentea F37D6.26
    Protein F37D6.2, isoform b
    14(a)
    1 → many
    I(10475522-10478129)
            Species with no ortholog for ZNF280C

    ENSEMBL Gene Tree for ZNF280C (if available)
    TreeFam Gene Tree for ZNF280C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF280C gene
    ZNF280A2  ZNF280D2  POGZ2  ZNF280B2  
    3 SIMAP similar genes for ZNF280C using alignment to 2 protein entries:     Z280C_HUMAN (see all proteins):
    ZNF280D    ZNF280B    ZNF280A

    ZNF280C for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/958 SNPs in ZNF280C are shown (see all 958)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs6837181,2
    C,A--129336212(+) AGCCTT/CGAACT 1 -- ds50014Minor allele frequency- C:0.00NA WA CSA 7
    rs4850951,2
    C--129336408(+) ATGAGC/ACATTG 1 -- ds50015Minor allele frequency- A:0.00WA NA CSA 9
    rs1824631991,2
    --129336676(+) AGTTAC/TATGAT 1 -- ut310--------
    rs128482961,2
    C--129336732(+) ACAATA/CCAAAT 1 -- ut310--------
    rs1866933621,2
    --129336819(+) AAAAAA/TATATA 1 -- ut310--------
    rs1926174801,2
    --129336867(+) TTGGTC/TCCAAT 1 -- ut310--------
    rs1847662561,2
    --129336945(+) ATGTAG/TAGAAA 1 -- ut310--------
    rs1903147541,2
    --129336950(+) TAGAAA/GTGTAA 1 -- ut310--------
    rs1489884871,2
    --129337040(+) GTTAAG/TGATAG 1 -- ut310--------
    rs1928099931,2
    --129337304(+) ACCTAC/GCTACC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ZNF280C (129336673 - 129402922 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZNF280C:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv528290CNV Gain19592680


    Locus Specific Mutation Databases (LSDB): ZNF280C
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF280C
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF280C

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF280C gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with ZNF280C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    5. A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells. (PubMed id 22412018)1 Roux K.J.... Burke B. (2012)
    6. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    7. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    8. Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
    9. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    10. Comparative proteomic analysis identifies a role for S UMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55609 HGNC: 25955 AceView: SUHW3 Ensembl:ENSG00000056277 euGenes: HUgn55609
    ECgene: ZNF280C H-InvDB: ZNF280C

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF280C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF280C gene:
    Search GeneIP for patents involving ZNF280C

    GeneCards and IP:
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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