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Aliases for ZNF280C Gene

Aliases for ZNF280C Gene

  • Zinc Finger Protein 280C 2 3 5
  • Suppressor Of Hairy Wing Homolog 3 3 4
  • Zinc Finger Protein 633 3 4
  • ZNF633 3 4
  • SUHW3 3 4
  • Suppressor Of Hairy Wing Homolog 3 (Drosophila) 2

External Ids for ZNF280C Gene

Previous HGNC Symbols for ZNF280C Gene

  • SUHW3

Previous GeneCards Identifiers for ZNF280C Gene

  • GC0XM129166
  • GC0XM129336
  • GC0XM118731

Summaries for ZNF280C Gene

Entrez Gene Summary for ZNF280C Gene

  • This gene encodes a member of the zinc finger domain-containing protein family. This family member contains multiple Cys2-His2(C2H2)-type zinc finger domains, the most common type of zinc finger domain that self-folds to form a beta-beta-alpha structure that binds a zinc ion. [provided by RefSeq, Aug 2011]

GeneCards Summary for ZNF280C Gene

ZNF280C (Zinc Finger Protein 280C) is a Protein Coding gene. An important paralog of this gene is POGZ.

UniProtKB/Swiss-Prot for ZNF280C Gene

  • May function as a transcription factor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF280C Gene

Genomics for ZNF280C Gene

Regulatory Elements for ZNF280C Gene

Enhancers for ZNF280C Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF280C on UCSC Golden Path with GeneCards custom track

Promoters for ZNF280C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF280C on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF280C Gene

130,202,699 bp from pter
130,269,068 bp from pter
66,370 bases
Minus strand

Genomic View for ZNF280C Gene

Genes around ZNF280C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF280C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF280C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF280C Gene

Proteins for ZNF280C Gene

  • Protein details for ZNF280C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 280C
    Protein Accession:
    Secondary Accessions:
    • A8K2V8
    • Q9NXR3

    Protein attributes for ZNF280C Gene

    737 amino acids
    Molecular mass:
    83096 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA90947.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

neXtProt entry for ZNF280C Gene

Proteomics data for ZNF280C Gene at MOPED

Post-translational modifications for ZNF280C Gene

  • Ubiquitination at Lys 689
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF280C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF280C Gene

Domains & Families for ZNF280C Gene

Protein Domains for ZNF280C Gene


Suggested Antigen Peptide Sequences for ZNF280C Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 5 C2H2-type zinc fingers.
  • Contains 5 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF280C: view

No data available for Gene Families for ZNF280C Gene

Function for ZNF280C Gene

Molecular function for ZNF280C Gene

UniProtKB/Swiss-Prot Function:
May function as a transcription factor.

Phenotypes for ZNF280C Gene

genes like me logo Genes that share phenotypes with ZNF280C: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF280C Gene

Localization for ZNF280C Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF280C Gene

Subcellular locations from

Jensen Localization Image for ZNF280C Gene COMPARTMENTS Subcellular localization image for ZNF280C gene
Compartment Confidence
nucleus 5
cytosol 3

No data available for Gene Ontology (GO) - Cellular Components for ZNF280C Gene

Pathways & Interactions for ZNF280C Gene

SuperPathways for ZNF280C Gene

No Data Available

Interacting Proteins for ZNF280C Gene

Gene Ontology (GO) - Biological Process for ZNF280C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IBA --
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF280C: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF280C Gene

Drugs & Compounds for ZNF280C Gene

No Compound Related Data Available

Transcripts for ZNF280C Gene

mRNA/cDNA for ZNF280C Gene

Unigene Clusters for ZNF280C Gene

Zinc finger protein 280C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF280C Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP2: -

Relevant External Links for ZNF280C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF280C Gene

mRNA expression in normal human tissues for ZNF280C Gene

Protein differential expression in normal tissues from HIPED for ZNF280C Gene

This gene is overexpressed in Testis (28.7), Peripheral blood mononuclear cells (26.0), and Ovary (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF280C Gene

SOURCE GeneReport for Unigene cluster for ZNF280C Gene Hs.308418

genes like me logo Genes that share expression patterns with ZNF280C: view

Protein tissue co-expression partners for ZNF280C Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF280C Gene

Orthologs for ZNF280C Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF280C Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZNF280C 35
  • 78.6 (n)
  • 66.72 (a)
ZNF280C 36
  • 67 (a)
(Canis familiaris)
Mammalia ZNF280C 35
  • 85.77 (n)
  • 77.82 (a)
ZNF280C 36
  • 76 (a)
(Mus musculus)
Mammalia Zfp280c 35
  • 78.29 (n)
  • 68.47 (a)
Zfp280c 16
Zfp280c 36
  • 66 (a)
(Pan troglodytes)
Mammalia ZNF280C 35
  • 98.58 (n)
  • 96.81 (a)
(Rattus norvegicus)
Mammalia Zfp280c 35
  • 77.78 (n)
  • 68.21 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 49 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 61 (a)
(Gallus gallus)
Aves -- 36
  • 43 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 36 (a)
(Danio rerio)
Actinopterygii znf280d 36
  • 35 (a)
fruit fly
(Drosophila melanogaster)
Insecta row 36
  • 12 (a)
(Caenorhabditis elegans)
Secernentea F37D6.2 36
  • 18 (a)
Species with no ortholog for ZNF280C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ZNF280C Gene

Gene Tree for ZNF280C (if available)
Gene Tree for ZNF280C (if available)

Paralogs for ZNF280C Gene

Paralogs for ZNF280C Gene

(3) SIMAP similar genes for ZNF280C Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF280C: view

Variants for ZNF280C Gene

Sequence variations from dbSNP and Humsavar for ZNF280C Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs747787365 -- 130,260,496(+) CAATG(C/T)TATGA intron-variant
rs747794455 -- 130,212,945(+) TGAGA(A/C)AGGAA intron-variant
rs747880293 -- 130,205,448(+) ATATT(C/T)TTATC intron-variant
rs747907128 -- 130,216,396(+) GTAGT(A/C)AATTC intron-variant
rs747909810 -- 130,263,016(+) GGATG(C/T)CACTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF280C Gene

Variant ID Type Subtype PubMed ID
nsv528290 CNV Gain 19592680

Variation tolerance for ZNF280C Gene

Residual Variation Intolerance Score: 18.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.51; 11.13% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF280C Gene

Disorders for ZNF280C Gene

Relevant External Links for ZNF280C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF280C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF280C Gene

Publications for ZNF280C Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3
  5. A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells. (PMID: 22412018) Roux K.J. … Burke B. (J. Cell Biol. 2012) 3

Products for ZNF280C Gene

Sources for ZNF280C Gene