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Aliases for ZNF280C Gene

Aliases for ZNF280C Gene

  • Zinc Finger Protein 280C 2 3 5
  • Suppressor Of Hairy Wing Homolog 3 3 4
  • Zinc Finger Protein 633 3 4
  • ZNF633 3 4
  • SUHW3 3 4
  • Suppressor Of Hairy Wing Homolog 3 (Drosophila) 2

External Ids for ZNF280C Gene

Previous HGNC Symbols for ZNF280C Gene

  • SUHW3

Previous GeneCards Identifiers for ZNF280C Gene

  • GC0XM129166
  • GC0XM129336
  • GC0XM118731

Summaries for ZNF280C Gene

Entrez Gene Summary for ZNF280C Gene

  • This gene encodes a member of the zinc finger domain-containing protein family. This family member contains multiple Cys2-His2(C2H2)-type zinc finger domains, the most common type of zinc finger domain that self-folds to form a beta-beta-alpha structure that binds a zinc ion. [provided by RefSeq, Aug 2011]

GeneCards Summary for ZNF280C Gene

ZNF280C (Zinc Finger Protein 280C) is a Protein Coding gene. An important paralog of this gene is ZNF280D.

UniProtKB/Swiss-Prot for ZNF280C Gene

  • May function as a transcription factor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF280C Gene

Genomics for ZNF280C Gene

Regulatory Elements for ZNF280C Gene

Enhancers for ZNF280C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF130183 0.6 Ensembl ENCODE 8.9 +85.3 85268 0.8 PKNOX1 ATF1 IKZF1 TBX21 GABPA ZNF280C RAB33A GC0XP130201
GH0XF130280 0.2 ENCODE 8.6 -11.9 -11887 1.0 PRDM1 RNU6-1130P ENSG00000225046 SLC25A14 ZNF280C GC0XM130311
GH0XF130198 0.2 ENCODE 8.2 +69.8 69753 1.1 KDM1A RAB33A AIFM1 ZNF280C GC0XP130201
GH0XF130170 1 FANTOM5 ENCODE 7.9 +96.4 96371 4.4 PKNOX1 ATF1 CREB3L1 SIN3A ELK1 GATA2 ZNF263 MEF2D MAFF SMARCA4 ZNF280C ELF4 RAB33A GC0XP130201
GH0XF130164 0.6 ENCODE 7.8 +103.3 103277 3.2 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A ZNF2 YY1 ZNF280C AIFM1 ELF4
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZNF280C on UCSC Golden Path with GeneCards custom track

Promoters for ZNF280C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000481997 968 2600 HDGF ATF1 PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF48 ZNF2

Genomic Location for ZNF280C Gene

Chromosome:
X
Start:
130,202,699 bp from pter
End:
130,269,068 bp from pter
Size:
66,370 bases
Orientation:
Minus strand

Genomic View for ZNF280C Gene

Genes around ZNF280C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF280C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF280C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF280C Gene

Proteins for ZNF280C Gene

  • Protein details for ZNF280C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8ND82-Z280C_HUMAN
    Recommended name:
    Zinc finger protein 280C
    Protein Accession:
    Q8ND82
    Secondary Accessions:
    • A8K2V8
    • Q9NXR3

    Protein attributes for ZNF280C Gene

    Size:
    737 amino acids
    Molecular mass:
    83096 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA90947.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

neXtProt entry for ZNF280C Gene

Post-translational modifications for ZNF280C Gene

  • Ubiquitination at Lys 689
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF280C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF280C Gene

Domains & Families for ZNF280C Gene

Protein Domains for ZNF280C Gene

Suggested Antigen Peptide Sequences for ZNF280C Gene

Graphical View of Domain Structure for InterPro Entry

Q8ND82

UniProtKB/Swiss-Prot:

Z280C_HUMAN :
  • Contains 5 C2H2-type zinc fingers.
Similarity:
  • Contains 5 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF280C: view

No data available for Gene Families for ZNF280C Gene

Function for ZNF280C Gene

Molecular function for ZNF280C Gene

UniProtKB/Swiss-Prot Function:
May function as a transcription factor.

Gene Ontology (GO) - Molecular Function for ZNF280C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding IBA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF280C: view

Phenotypes for ZNF280C Gene

genes like me logo Genes that share phenotypes with ZNF280C: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF280C Gene

Localization for ZNF280C Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF280C Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF280C Gene COMPARTMENTS Subcellular localization image for ZNF280C gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for ZNF280C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF280C: view

Pathways & Interactions for ZNF280C Gene

SuperPathways for ZNF280C Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF280C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007411 axon guidance IBA --
GO:0045892 negative regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF280C: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF280C Gene

Transcripts for ZNF280C Gene

mRNA/cDNA for ZNF280C Gene

Unigene Clusters for ZNF280C Gene

Zinc finger protein 280C:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF280C Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1:
SP2: -

Relevant External Links for ZNF280C Gene

GeneLoc Exon Structure for
ZNF280C
ECgene alternative splicing isoforms for
ZNF280C

Expression for ZNF280C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF280C Gene

Protein differential expression in normal tissues from HIPED for ZNF280C Gene

This gene is overexpressed in Testis (28.7), Peripheral blood mononuclear cells (26.0), and Ovary (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF280C Gene



Protein tissue co-expression partners for ZNF280C Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF280C Gene:

ZNF280C

SOURCE GeneReport for Unigene cluster for ZNF280C Gene:

Hs.308418
genes like me logo Genes that share expression patterns with ZNF280C: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF280C Gene

Orthologs for ZNF280C Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF280C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF280C 34
  • 98.58 (n)
dog
(Canis familiaris)
Mammalia ZNF280C 34 35
  • 85.77 (n)
cow
(Bos Taurus)
Mammalia ZNF280C 34 35
  • 78.6 (n)
mouse
(Mus musculus)
Mammalia Zfp280c 34 16 35
  • 78.29 (n)
rat
(Rattus norvegicus)
Mammalia Zfp280c 34
  • 77.78 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 61 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 49 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 43 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 36 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii znf280d 35
  • 35 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta row 35
  • 12 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F37D6.2 35
  • 18 (a)
OneToMany
Species where no ortholog for ZNF280C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ZNF280C Gene

ENSEMBL:
Gene Tree for ZNF280C (if available)
TreeFam:
Gene Tree for ZNF280C (if available)

Paralogs for ZNF280C Gene

Paralogs for ZNF280C Gene

(3) SIMAP similar genes for ZNF280C Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF280C: view

Variants for ZNF280C Gene

Sequence variations from dbSNP and Humsavar for ZNF280C Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs10126901 -- 130,248,956(+) cactc(C/T)gccca intron-variant
rs10482404 -- 130,250,466(+) cccag(A/G)aaaat intron-variant
rs111248743 -- 130,207,630(+) GTGCT(A/G)GGATT intron-variant
rs111257511 -- 130,228,873(+) ATTAC(A/G)AAGTC intron-variant
rs111288589 -- 130,267,312(+) TATAA(A/T)GGAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF280C Gene

Variant ID Type Subtype PubMed ID
dgv2425e212 CNV loss 25503493
dgv2426e212 CNV gain 25503493
esv3368010 CNV insertion 20981092
esv3577252 CNV gain 25503493
nsv528290 CNV gain 19592680

Variation tolerance for ZNF280C Gene

Residual Variation Intolerance Score: 18.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.51; 11.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF280C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF280C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF280C Gene

Disorders for ZNF280C Gene

Relevant External Links for ZNF280C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF280C

No disorders were found for ZNF280C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF280C Gene

Publications for ZNF280C Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  5. The Deubiquitinase USP37 Regulates Chromosome Cohesion and Mitotic Progression. (PMID: 26299517) Yeh C. … Pelletier L. (Curr. Biol. 2015) 3 64

Products for ZNF280C Gene

Sources for ZNF280C Gene

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