ZNF280C Gene
protein-coding GIFtS: 41
GCID: GC0XM129336
|
|
zinc finger protein 280C(Previous name: suppressor of hairy wing homolog 3 (Drosophila) )
(Previous symbol: SUHW3)
| |
Aliases
for ZNF280C gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 280C1 2 | | Zinc Finger Protein 6332 3 | | SUHW31 2 3 | | FLJ200951 | | ZNF6331 2 3 | | Suppressor Of Hairy Wing Homolog 3 (Drosophila)1 | | Suppressor Of Hairy Wing Homolog 32 3 | | |
Export aliases for ZNF280C gene to outside databasesPrevious GC identifers: GC0XM129166 GC0XM118731 |
Summaries
for ZNF280C gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ZNF280C:
This gene encodes a member of the zinc finger domain-containing protein family. This family member contains multipleCys2-His2(C2H2)-type zinc finger domains, the most common type of zinc finger domain that self-folds to form abeta-beta-alpha structure that binds a zinc ion. (provided by RefSeq, Aug 2011)
UniProtKB/Swiss-Prot: Z280C_HUMAN, Q8ND82Function: May function as a transcription factor
|
Genomic Views
for ZNF280C gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011786.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF280C gene promoter:
Pbx1a Brachyury Meis-1a Pax-4a TGIF YY1 Meis-1 Meis-1b
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF280C
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF280C |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq26.1 Ensembl cytogenetic band: Xq26.1 HGNC cytogenetic band: Xq25ZNF280C Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM129336: view genomic region
(about GC identifiers)
Start:
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129,336,673 bp from pter |
End:
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129,402,922 bp from pter |
Size:
|
66,250 bases |
Orientation:
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minus strand |
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Proteins
for ZNF280C gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: Z280C_HUMAN, Q8ND82 (See
protein sequence)Recommended Name: Zinc finger protein 280C Size: 737 amino acids; 83096 Da
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=BAA90947.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-Asequence;
Secondary accessions: A8K2V8 Q9NXR3Explore the universe of human proteins at neXtProt for ZNF280C: NX_Q8ND82
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8ND82
ZNF280C Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060136.1
ENSEMBL proteins: ENSP00000360017 ENSP00000408521
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZNF280C for ontologies About GeneDecksing
ZNF280C Antibody Products:
Assay Products for ZNF280C: |
Protein
Domains /
Families
for ZNF280C gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF280C for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8ND82ProtoNet protein and cluster: Q8ND82 UniProtKB/Swiss-Prot: Z280C_HUMAN, Q8ND82Similarity: Contains 5 C2H2-type zinc fingers |
Function
for ZNF280C gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: Z280C_HUMAN, Q8ND82Function: May function as a transcription factor
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF280C
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF280C |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
ZNF280C for ontologies About GeneDecksing
|
Pathways & Interactions
for ZNF280C gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF280C
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for ZNF280C (ENSP000003600174) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF280C for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF280C gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF280C
Search CenterWatch for drugs/clinical trials and news about ZNF280C / Z280C
|
Transcripts
for ZNF280C gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF280C gene: NM_017666.4 Unigene Cluster for ZNF280C: Zinc finger protein 280C Hs.308418 [show with all ESTs]Unigene Representative Sequence: BC0517282 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000370978(uc004evm.3 uc010nrf.2) ENST00000447817
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF280C
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF280C
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF280C (NM_017666) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF280C | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF280C |
Additional cDNA sequence: AK000102.1 AK290373.1 AL133204.1 AL834333.1 BC051728.1 3 DOTS entries: DT.91753790 DT.95268359 DT.100747155 24/35 AceView cDNA sequences (see all 35): AL133204 BE139550 BX474223 AA805654 AI681269 BX092851 AA773325 CR603297 BE501625 AI923562 BM456831 AL600988 BC051728 NM_017666 AL834333 BG566123 AW611940 BX441545 BX413265 BG718445 BX952878 AK000102 BG719141 CA306758
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF280C About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZNF280C
|
Expression
for ZNF280C gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF280C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTCTGTCTTG
About this image
See ZNF280C Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF280C
SOURCE GeneReport for Unigene cluster: Hs.308418
SABiosciences Custom PCR Arrays for ZNF280C
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF280C
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF280C |
Orthologs
for ZNF280C gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ZNF280C gene from 5/14 species (see all 14) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
-- |
Uncharacterized protein |
57(a) |
1 → many |
10(8647480-8684052) |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
35(a) |
1 → many |
GL343573.1(438826-450503) |
zebrafish
(Danio rerio) |
Actinopterygii |
znf280d6 |
zinc finger protein 280D |
34(a) |
1 → many |
7(54171798-54206632) |
fruit fly
(Drosophila melanogaster) |
Insecta |
row6 |
relative of woc |
9(a) |
1 → many |
2R(11094032-11101137) |
worm
(Caenorhabditis elegans) |
Secernentea |
F37D6.26 |
Protein F37D6.2, isoform a |
14(a) |
1 → many |
I(10475513-10478120) |
ENSEMBL Gene Tree for ZNF280C (if available)
TreeFam Gene Tree for ZNF280C (if available) |
Paralogs
for ZNF280C gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF280C gene
- ZNF280A2 ZNF280D2 POGZ2 ZNF280B2
3 SIMAP similar genes for ZNF280C using alignment to 2 protein entries: Z280C_HUMAN (see all proteins):ZNF280D ZNF280B ZNF280A
ZNF280C for paralogs About GeneDecksing
|
Genomic Variants
for ZNF280C gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF280C (129336673 - 129402922 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF280C: --
Locus Specific Mutation Databases (LSDB): ZNF280C
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF280C |
|
Disorders
/ Diseases
for ZNF280C gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ZNF280C gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF280C gene, integrated from 9 sources (see all 20):
(articles sorted by number of sources associating them with ZNF280C) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Comparative proteomic analysis identifies a role for S UMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
|
External Searches for ZNF280C gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF280C gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF280C gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF280C gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF280C | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF280C gene:
Search GeneIP for patents involving ZNF280C
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF280C gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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variant library, vector shuttling | | | OriGene Custom Antibody Services for ZNF280C | | OriGene Custom Protein Services for ZNF280C | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF280C | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF280C | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF280C | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF280C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF280C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF280C |
| |
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| |  |  |  |  | | | | |
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 | | | ZNF280C Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF280C |
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