ZNF280B Gene
protein-coding GIFtS: 40
GCID: GC22M022838
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zinc finger protein 280B(Previous names: zinc finger protein 279, suppressor of hairy wing homolog...)
(Previous symbols: ZNF279, SUHW2)
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Aliases
for ZNF280B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 280B1 2 | | ZNF6321 2 3 | | Zinc Finger Protein 2791 2 3 | | Suppressor Of Hairy Wing Homolog 22 3 | | 5'OY11.11 2 3 | | Zinc Finger Protein 6322 3 | | SUHW21 2 3 | | Suppressor Of Hairy Wing Homolog 2 (Drosophila)1 | | ZNF2791 2 3 | | D87009.C22.32 |
Export aliases for ZNF280B gene to outside databasesPrevious GC identifers: GC22M021168 GC22M005797 |
Summaries
for ZNF280B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ZNF280B:
This gene was identified by homology to other species. Its encoded protein is approximately 78-88% identical to apredicted sheep protein of unknown function. The protein is also approximately 25% identical to the Drosophila proteinsuppressor of hairy wing, which is a leucine zipper protein that represses the function of transcriptional enhancersof the gypsy retrotransposon. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: Z280B_HUMAN, Q86YH2Function: May function as a transcription factor
|
Genomic Views
for ZNF280B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011520.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF280B gene promoter:
c-Fos AhR AP-1 GCNF Tal-1beta GCNF-1 c-Jun Pax-4a ITF-2 GCNF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF280B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF280B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q11.22 Ensembl cytogenetic band: 22q11.22 HGNC cytogenetic band: 22q11.2ZNF280B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22M022838: view genomic region
(about GC identifiers)
Start:
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22,838,767 bp from pter |
End:
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22,863,505 bp from pter |
Size:
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24,739 bases |
Orientation:
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minus strand |
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Proteins
for ZNF280B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: Z280B_HUMAN, Q86YH2 (See
protein sequence)Recommended Name: Zinc finger protein 280B Size: 543 amino acids; 61584 Da
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=BAA20005.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Explore the universe of human proteins at neXtProt for ZNF280B: NX_Q86YH2
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86YH2
ZNF280B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_542942.1
ENSEMBL proteins: ENSP00000385998 ENSP00000353586
Human Recombinant Protein Products for ZNF280B:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
ZNF280B for ontologies About GeneDecksing
ZNF280B Antibody Products:
Assay Products for ZNF280B: |
Protein
Domains /
Families
for ZNF280B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF280B for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q86YH2ProtoNet protein and cluster: Q86YH2 UniProtKB/Swiss-Prot: Z280B_HUMAN, Q86YH2Similarity: Contains 4 C2H2-type zinc fingers |
Function
for ZNF280B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: Z280B_HUMAN, Q86YH2Function: May function as a transcription factor Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
ZNF280B for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for ZNF280B:
Animal Models:
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF280B
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF280B |
|
Pathways & Interactions
for ZNF280B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF280B
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for ZNF280B (ENSP000003535864) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF280B for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF280B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF280B
Search CenterWatch for drugs/clinical trials and news about ZNF280B / Z280B
|
Transcripts
for ZNF280B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF280B gene: NM_080764.2 Unigene Cluster for ZNF280B: Zinc finger protein 280B Hs.43834 [show with all ESTs]Unigene Representative Sequence: NM_0807642 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000406426 ENST00000360412(uc002zwc.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF280B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF280B
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF280B (NM_080764) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF280B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF280B |
Additional cDNA sequence: AK097608.1 BC035376.1 BC040020.2 BC042370.1 CR456614.1 8 DOTS entries: DT.99935525 DT.442827 DT.211308 DT.120677192 DT.95097084 DT.100735577 DT.120678017 DT.95364568 24/64 AceView cDNA sequences (see all 64): AA923227 BI492558 CB156631 BQ221117 AA333348 AW663885 N31273 N26665 NM_080764 AI207086 BX492870 W31789 AA760995 BX093302 N36258 BI828153 AA922139 BC040020 AA868010 AA737071 CB133948 CR456614 CB158626 AA693959
GeneLoc Exon Structure
|
Expression
for ZNF280B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF280B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See ZNF280B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF280B
SOURCE GeneReport for Unigene cluster: Hs.43834
SABiosciences Custom PCR Arrays for ZNF280B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF280B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNF280B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF280B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF280B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF280B |
Orthologs
for ZNF280B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ZNF280B gene from 3/14 species (see all 14) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
zebrafish
(Danio rerio) |
Actinopterygii |
znf280d6 |
zinc finger protein 280D |
22(a) |
1 → many |
7(54171798-54206632) |
fruit fly
(Drosophila melanogaster) |
Insecta |
row6 |
relative of woc |
8(a) |
1 → many |
2R(11094032-11101137) |
worm
(Caenorhabditis elegans) |
Secernentea |
F37D6.26 |
Protein F37D6.2, isoform a |
12(a) |
1 → many |
I(10475513-10478120) |
ENSEMBL Gene Tree for ZNF280B (if available)
TreeFam Gene Tree for ZNF280B (if available) |
Paralogs
for ZNF280B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF280B gene
- ZNF280A2 ZNF280D2 POGZ2 ZNF280C2
4 SIMAP similar genes for ZNF280B using alignment to 1 protein entry: Z280B_HUMAN:ZNF280A ZNF280D ZNF280C POGZ
ZNF280B for paralogs About GeneDecksing
|
Genomic Variants
for ZNF280B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF280B (22838767 - 22863505 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 32 variations for ZNF280B
15/32 CNVs (see all 32): 59061 35986 10616 34540 10613 5356 53983 35989 5451 9835 2266 5175 53738 10610 67849 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF280B |
|
Disorders
/ Diseases
for ZNF280B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ZNF280B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF280B gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF280B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- One-megabase sequence analysis of the human immunoglobulin lambda gene locus. (PubMed id 9074928)1, 2, 3 Kawasaki K....Shimizu N. (1997)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
- The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- A genome-wide search for loci interacting with known p rostate cancer risk-associated genetic variants. (PubMed id 22219177)1 Tao S....Sun J. (2012)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for ZNF280B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF280B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF280B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF280B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF280B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF280B gene:
Search GeneIP for patents involving ZNF280B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF280B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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 | | | ZNF280B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF280B |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF280B |
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