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Aliases for ZNF280B Gene

Aliases for ZNF280B Gene

  • Zinc Finger Protein 280B 2 3 5
  • Zinc Finger Protein 279 2 3 4
  • Suppressor Of Hairy Wing Homolog 2 3 4
  • Zinc Finger Protein 632 3 4
  • 5OY11.1 3 4
  • ZNF279 3 4
  • ZNF632 3 4
  • SUHW2 3 4
  • Suppressor Of Hairy Wing Homolog 2 (Drosophila) 2
  • D87009.C22.3 3

External Ids for ZNF280B Gene

Previous HGNC Symbols for ZNF280B Gene

  • ZNF279
  • SUHW2

Previous GeneCards Identifiers for ZNF280B Gene

  • GC22M021168
  • GC22M022838
  • GC22M005797

Summaries for ZNF280B Gene

Entrez Gene Summary for ZNF280B Gene

  • The protein encoded by this gene is a transcription factor that upregulates expression of MDM2, which negatively regulates p53 expression. This gene is highly expressed in prostate cancer cells, which leads to a reduction in p53 levels and an increase in growth of the cancer cells. Several transcript variants have been found for this gene, but only one of them is protein-coding. [provided by RefSeq, Jan 2015]

GeneCards Summary for ZNF280B Gene

ZNF280B (Zinc Finger Protein 280B) is a Protein Coding gene. An important paralog of this gene is POGZ.

UniProtKB/Swiss-Prot for ZNF280B Gene

  • May function as a transcription factor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF280B Gene

Genomics for ZNF280B Gene

Regulatory Elements for ZNF280B Gene

Promoters for ZNF280B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF280B on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF280B Gene

Chromosome:
22
Start:
22,484,421 bp from pter
End:
22,509,187 bp from pter
Size:
24,767 bases
Orientation:
Minus strand

Genomic View for ZNF280B Gene

Genes around ZNF280B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF280B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF280B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF280B Gene

Proteins for ZNF280B Gene

  • Protein details for ZNF280B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YH2-Z280B_HUMAN
    Recommended name:
    Zinc finger protein 280B
    Protein Accession:
    Q86YH2

    Protein attributes for ZNF280B Gene

    Size:
    543 amino acids
    Molecular mass:
    61584 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA20005.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for ZNF280B Gene

Proteomics data for ZNF280B Gene at MOPED

Post-translational modifications for ZNF280B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF280B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ZNF280B Gene

Domains & Families for ZNF280B Gene

Protein Domains for ZNF280B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF280B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86YH2

UniProtKB/Swiss-Prot:

Z280B_HUMAN :
  • Contains 4 C2H2-type zinc fingers.
Similarity:
  • Contains 4 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF280B: view

No data available for Gene Families for ZNF280B Gene

Function for ZNF280B Gene

Molecular function for ZNF280B Gene

UniProtKB/Swiss-Prot Function:
May function as a transcription factor.
genes like me logo Genes that share phenotypes with ZNF280B: view

Animal Model Products

CRISPR Products

miRNA for ZNF280B Gene

miRTarBase miRNAs that target ZNF280B

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF280B Gene

Localization for ZNF280B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF280B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF280B Gene COMPARTMENTS Subcellular localization image for ZNF280B gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for ZNF280B Gene

Pathways & Interactions for ZNF280B Gene

SuperPathways for ZNF280B Gene

No Data Available

Interacting Proteins for ZNF280B Gene

Gene Ontology (GO) - Biological Process for ZNF280B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IBA --
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF280B: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF280B Gene

Drugs & Compounds for ZNF280B Gene

No Compound Related Data Available

Transcripts for ZNF280B Gene

Unigene Clusters for ZNF280B Gene

Zinc finger protein 280B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF280B Gene

No ASD Table

Relevant External Links for ZNF280B Gene

GeneLoc Exon Structure for
ZNF280B
ECgene alternative splicing isoforms for
ZNF280B

Expression for ZNF280B Gene

mRNA expression in normal human tissues for ZNF280B Gene

mRNA differential expression in normal tissues according to GTEx for ZNF280B Gene

This gene is overexpressed in Testis (x11.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ZNF280B Gene



SOURCE GeneReport for Unigene cluster for ZNF280B Gene Hs.43834

genes like me logo Genes that share expression patterns with ZNF280B: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZNF280B Gene

Orthologs for ZNF280B Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF280B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF280B 35
  • 85.99 (n)
  • 79.27 (a)
dog
(Canis familiaris)
Mammalia ZNF280B 35
  • 87.61 (n)
  • 81.78 (a)
mouse
(Mus musculus)
Mammalia Zfp280b 35
  • 76.05 (n)
  • 71.02 (a)
Zfp280b 16
chimpanzee
(Pan troglodytes)
Mammalia ZNF280B 35
  • 99.69 (n)
  • 99.26 (a)
rat
(Rattus norvegicus)
Mammalia Zfp280b 35
  • 72.42 (n)
  • 67.87 (a)
Species with no ortholog for ZNF280B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF280B Gene

ENSEMBL:
Gene Tree for ZNF280B (if available)
TreeFam:
Gene Tree for ZNF280B (if available)

Paralogs for ZNF280B Gene

Paralogs for ZNF280B Gene

(4) SIMAP similar genes for ZNF280B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZNF280B: view

Variants for ZNF280B Gene

Sequence variations from dbSNP and Humsavar for ZNF280B Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs2236729 - 22,488,632(+) CATTT(G/T)CCCTA intron-variant, nc-transcript-variant, reference, missense
rs12484816 - 22,487,834(+) TGCTC(A/C)CAGTT intron-variant, nc-transcript-variant, reference, missense
rs11109 -- 22,487,881(+) TCCAG(C/T)GACAC intron-variant, nc-transcript-variant, reference, synonymous-codon
rs393829 -- 22,484,081(+) AATTA(A/C)AAACT downstream-variant-500B
rs398182 -- 22,485,078(+) AGTGC(A/G)TCATT nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF280B Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER Inversion 18451855
nsv526328 CNV Gain 19592680
nsv459421 CNV Gain 19166990
nsv817937 CNV Loss 17921354
dgv548n27 CNV Loss 19166990
nsv459450 CNV Loss 19166990
esv2422480 CNV Deletion 17116639
nsv828977 CNV Loss 20364138
nsv828979 CNV Gain+Loss 20364138
dgv731n67 CNV Loss 20364138
dgv550n27 CNV Loss 19166990
dgv38n64 CNV Loss 17921354
dgv551n27 CNV Loss 19166990
nsv438338 CNV Loss 16468122
nsv834149 CNV Loss 17160897
esv1007524 CNV Gain 20482838
nsv469735 CNV Loss 16826518
dgv39n64 CNV Loss 17921354
dgv23n14 CNV Loss 18776910
dgv555n27 CNV Loss 19166990
dgv556n27 CNV Loss 19166990
dgv557n27 CNV Loss 19166990
dgv558n27 CNV Loss 19166990
nsv819428 CNV Gain 19587683
nsv514963 CNV Complex 21397061
nsv817953 CNV Gain 17921354
nsv834150 CNV Loss 17160897
nsv817956 CNV Loss 17921354
nsv459538 CNV Loss 19166990
nsv459539 CNV Loss 19166990
nsv821694 CNV Loss 15273396
nsv817957 CNV Gain 17921354
nsv915211 CNV Loss 21882294
nsv459546 CNV Loss 19166990
nsv817958 CNV Gain 17921354
nsv915212 CNV Gain 21882294
nsv508727 CNV Insertion 20534489
nsv511072 CNV Complex 20534489
nsv459548 CNV Loss 19166990
esv33016 CNV Gain 17666407

Variation tolerance for ZNF280B Gene

Residual Variation Intolerance Score: 73.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.77; 33.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF280B Gene

HapMap Linkage Disequilibrium report
ZNF280B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF280B Gene

Disorders for ZNF280B Gene

Relevant External Links for ZNF280B

Genetic Association Database (GAD)
ZNF280B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF280B

No disorders were found for ZNF280B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF280B Gene

Publications for ZNF280B Gene

  1. One-megabase sequence analysis of the human immunoglobulin lambda gene locus. (PMID: 9074928) Kawasaki K. … Shimizu N. (Genome Res. 1997) 2 3 4 67
  2. Zinc Finger 280B regulates sGCI+1 and p53 in prostate cancer cells. (PMID: 24236047) Gao S. … Shemshedini L. (PLoS ONE 2013) 3
  3. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. (PMID: 22219177) Tao S. … Sun J. (Carcinogenesis 2012) 3
  4. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PMID: 22990118) Woods N.T. … Monteiro A.N. (Sci Signal 2012) 3
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for ZNF280B Gene

Sources for ZNF280B Gene

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