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ZNF280B Gene

protein-coding   GIFtS: 45
GCID: GC22M022838

Zinc Finger Protein 280B

(Previous names: zinc finger protein 279, suppressor of hairy wing homolog...)
(Previous symbols: ZNF279, SUHW2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 280B1 2     Zinc Finger Protein 6322 3
Zinc Finger Protein 2791 2 3     5'OY11.12 3
SUHW21 2 3     ZNF6322 3
ZNF2791 2 3     Suppressor Of Hairy Wing Homolog 2 (Drosophila)1
Suppressor Of Hairy Wing Homolog 22 3     D87009.C22.32

External Ids:    HGNC: 230221   Entrez Gene: 1408832   Ensembl: ENSG000001984777   UniProtKB: Q86YH23   

Export aliases for ZNF280B gene to outside databases

Previous GC identifers: GC22M021168 GC22M005797


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ZNF280B Gene:
This gene was identified by homology to other species. Its encoded protein is approximately 78-88% identical to a
predicted sheep protein of unknown function. The protein is also approximately 25% identical to the Drosophila
protein suppressor of hairy wing, which is a leucine zipper protein that represses the function of
transcriptional enhancers of the gypsy retrotransposon. (provided by RefSeq, Jul 2008)

GeneCards Summary for ZNF280B Gene:
ZNF280B (zinc finger protein 280B) is a protein-coding gene. Diseases associated with ZNF280B include prostate cancer, and prostatitis. An important paralog of this gene is ZNF280A.

UniProtKB/Swiss-Prot: Z280B_HUMAN, Q86YH2
Function: May function as a transcription factor




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000022.11  NT_011520.13  NT_187629.1  NC_018933.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF280B gene promoter:
         c-Fos   AhR   AP-1   GCNF   Tal-1beta   GCNF-1   c-Jun   Pax-4a   ITF-2   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF280B promoter sequence
   Search Chromatin IP Primers for ZNF280B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF280B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.22   Ensembl cytogenetic band:  22q11.22   HGNC cytogenetic band: 22q11.2

ZNF280B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF280B gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M022838:  view genomic region     (about GC identifiers)

Start:
22,838,767 bp from pter      End:
22,863,505 bp from pter
Size:
24,739 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: Z280B_HUMAN, Q86YH2 (See protein sequence)
Recommended Name: Zinc finger protein 280B  
Size: 543 amino acids; 61584 Da
Sequence caution: Sequence=BAA20005.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Explore the universe of human proteins at neXtProt for ZNF280B: NX_Q86YH2

Explore proteomics data for ZNF280B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF280B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_542942.1  
    ENSEMBL proteins: 
     ENSP00000385998   ENSP00000353586  

    ZNF280B Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR025243 DUF4195
     IPR015880 Znf_C2H2-like
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q86YH2

    ProtoNet protein and cluster: Q86YH2

    UniProtKB/Swiss-Prot: Z280B_HUMAN, Q86YH2
    Similarity: Contains 4 C2H2-type zinc fingers


    ZNF280B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: Z280B_HUMAN, Q86YH2
    Function: May function as a transcription factor

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    ZNF280B for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF280B:
     Decreased Wnt reporter activit 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF280B
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    miRNA
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    miRTarBase miRNAs that target ZNF280B:
    hsa-let-7f-5p (MIRT051397), hsa-let-7d-5p (MIRT032184), hsa-mir-877-5p (MIRT037330)

    Block miRNA regulation of human, mouse, rat ZNF280B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZNF280B (see all 62):
    hsa-miR-4317 hsa-let-7d hsa-miR-4272 hsa-miR-106a hsa-miR-30d hsa-let-7g hsa-miR-4314 hsa-miR-30a
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    Z280B_HUMAN, Q86YH2: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    ZNF280B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF280B
    Interactions:

        Search GeneGlobe Interaction Network for ZNF280B

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ZNF280B (ENSP000003535864) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    ZNF280B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF280B (Z280B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZNF280B gene: 
    NM_080764.2  

    Unigene Cluster for ZNF280B:

    Zinc finger protein 280B
    Hs.43834  [show with all ESTs]
    Unigene Representative Sequence: NM_080764
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000406426 ENST00000360412(uc002zwc.1)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ZNF280B (see all 62):
    hsa-miR-4317 hsa-let-7d hsa-miR-4272 hsa-miR-106a hsa-miR-30d hsa-let-7g hsa-miR-4314 hsa-miR-30a
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      QuantiFast Probe-based Assays in human, mouse, rat ZNF280B

    Additional mRNA sequence: 

    AK097608.1 BC035376.1 BC040020.2 BC042370.1 CR456614.1 

    8 DOTS entries:

    DT.99935525  DT.442827  DT.211308  DT.120677192  DT.95097084  DT.100735577  DT.120678017  DT.95364568 

    Selected AceView cDNA sequences (see all 64):

    NM_080764 BQ221117 AW663885 CB156631 BI492558 N31273 N26665 AA333348 
    AA923227 N35016 AW173330 BX108144 BI523641 BQ219363 AI207086 AK097608 
    AA868010 BC035376 CB133948 AW104458 N36258 AA922139 CB158626 BX093302 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF280B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZNF280B Expression
    About this image

    ZNF280B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF280B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.43834
        Custom PCR Arrays for ZNF280B
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ZNF280B gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp280b1 , 5 zinc finger protein 280B1, 5 76.05(n)1
    71.02(a)1
      10 (38.67 cM)5
    644531  NM_177475.31  NP_803426.21 
     760326125 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    27(a)
    1 → many
    10(7094684-7137592)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    25(a)
    1 → many
    GL343573.1(438826-450503)
    zebrafish
    (Danio rerio)
    Actinopterygii znf280d6
    zinc finger protein 280D
    23(a)
    1 → many
    7(54171798-54206632) ENSDARG00000077013
    fruit fly
    (Drosophila melanogaster)
    Insecta row6
    relative of woc
    9(a)
    1 → many
    2R(11094032-11101137)
    worm
    (Caenorhabditis elegans)
    Secernentea F37D6.26
    Protein F37D6.2, isoform b (F37D6.2) mRNA, complet...
    17(a)
    1 → many
    I(10475522-10478129) WBGene00009508


    ENSEMBL Gene Tree for ZNF280B (if available)
    TreeFam Gene Tree for ZNF280B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF280B gene
    ZNF280A2  ZNF280D2  POGZ2  ZNF280C2  
    4 SIMAP similar genes for ZNF280B using alignment to 1 protein entry:     Z280B_HUMAN:
    ZNF280A    ZNF280D    ZNF280C    POGZ

    ZNF280B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF280B (see all 601)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1494686431,2
    --22838304(+) TGACAA/GAGCGA 1 -- ds50010--------
    rs3938291,2
    C,H--22838416(+) AATTAC/AAAACT 1 -- ds500112Minor allele frequency- A:0.16NA WA CSA EA 375
    rs1439505941,2
    --22838554(+) AAAAGC/TACAAA 1 -- ds50010--------
    rs1398807381,2
    C--22838617(+) CACTTC/GAACTC 1 -- ds50010--------
    rs1893360851,2
    --22838684(+) CAGAGA/CGAGAC 1 -- ds50010--------
    rs1430486891,2
    C--22838705(+) AAAAC-/AAAACA 1 -- ds50010--------
    rs3889211,2
    C,F,A,H--22838738(+) GGAAAA/GACAAT 1 -- ds500113Minor allele frequency- G:0.30NS EA NA 1952
    rs559339241,2
    C--22838738(+) GGAAA-/GACA  
     ATACAGC
    AACAA
    1 -- ds50011Minor allele frequency- GACAATACAGC:0.00NA 2
    rs1817536821,2
    --22838924(+) TATTCA/GATATA 1 -- ut310--------
    rs4147811,2
    C,F,O,H--22839096(+) TGATGA/CTGATC 1 -- ut3128Minor allele frequency- C:0.18NS EA NA WA CSA 2439

    HapMap Linkage Disequilibrium report for ZNF280B (22838767 - 22863505 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ZNF280B (see all 40):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422480CNV Deletion17116639
    nsv508727CNV Insertion20534489
    nsv817956CNV Loss17921354
    nsv459546CNV Loss19166990
    nsv834150CNV Loss17160897
    nsv469735CNV Loss16826518
    dgv551n27CNV Loss19166990
    nsv817937CNV Loss17921354
    dgv39n64CNV Loss17921354
    dgv38n64CNV Loss17921354

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases for ZNF280B:    
    About MalaCards
    prostate cancer    prostatitis


    ZNF280B for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZNF280B

    Export disorders for ZNF280B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF280B gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with ZNF280B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. One-megabase sequence analysis of the human immunoglobulin lambda gene locus. (PubMed id 9074928)1, 2, 3 Kawasaki K.... Shimizu N. (Genome Res. 1997)
    2. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. (PubMed id 22219177)1, 4 Tao S....Sun J. (Carcinogenesis 2012)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)
    5. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I.... Wright H. (Nature 1999)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    8. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (Anal. Chem. 2009)
    9. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 140883 HGNC: 23022 AceView: SUHW2 Ensembl:ENSG00000198477 euGenes: HUgn140883
    ECgene: ZNF280B H-InvDB: ZNF280B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF280B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF280B gene:
    Search GeneIP for patents involving ZNF280B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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