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Aliases for ZNF280B Gene

Aliases for ZNF280B Gene

  • Zinc Finger Protein 280B 2 3 5
  • Zinc Finger Protein 279 2 3 4
  • Suppressor Of Hairy Wing Homolog 2 3 4
  • Zinc Finger Protein 632 3 4
  • 5OY11.1 3 4
  • ZNF279 3 4
  • ZNF632 3 4
  • SUHW2 3 4
  • Suppressor Of Hairy Wing Homolog 2 (Drosophila) 2
  • D87009.C22.3 3

External Ids for ZNF280B Gene

Previous HGNC Symbols for ZNF280B Gene

  • ZNF279
  • SUHW2

Previous GeneCards Identifiers for ZNF280B Gene

  • GC22M021168
  • GC22M022838
  • GC22M005797

Summaries for ZNF280B Gene

Entrez Gene Summary for ZNF280B Gene

  • The protein encoded by this gene is a transcription factor that upregulates expression of MDM2, which negatively regulates p53 expression. This gene is highly expressed in prostate cancer cells, which leads to a reduction in p53 levels and an increase in growth of the cancer cells. Several transcript variants have been found for this gene, but only one of them is protein-coding. [provided by RefSeq, Jan 2015]

GeneCards Summary for ZNF280B Gene

ZNF280B (Zinc Finger Protein 280B) is a Protein Coding gene. An important paralog of this gene is ZNF280A.

UniProtKB/Swiss-Prot for ZNF280B Gene

  • May function as a transcription factor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF280B Gene

Genomics for ZNF280B Gene

Regulatory Elements for ZNF280B Gene

Enhancers for ZNF280B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ZNF280B on UCSC Golden Path with GeneCards custom track

Promoters for ZNF280B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF280B on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF280B Gene

Chromosome:
22
Start:
22,484,421 bp from pter
End:
22,509,187 bp from pter
Size:
24,767 bases
Orientation:
Minus strand

Genomic View for ZNF280B Gene

Genes around ZNF280B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF280B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF280B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF280B Gene

Proteins for ZNF280B Gene

  • Protein details for ZNF280B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YH2-Z280B_HUMAN
    Recommended name:
    Zinc finger protein 280B
    Protein Accession:
    Q86YH2

    Protein attributes for ZNF280B Gene

    Size:
    543 amino acids
    Molecular mass:
    61584 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA20005.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for ZNF280B Gene

Post-translational modifications for ZNF280B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF280B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF280B Gene

Domains & Families for ZNF280B Gene

Protein Domains for ZNF280B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF280B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86YH2

UniProtKB/Swiss-Prot:

Z280B_HUMAN :
  • Contains 4 C2H2-type zinc fingers.
Similarity:
  • Contains 4 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF280B: view

No data available for Gene Families for ZNF280B Gene

Function for ZNF280B Gene

Molecular function for ZNF280B Gene

UniProtKB/Swiss-Prot Function:
May function as a transcription factor.

Gene Ontology (GO) - Molecular Function for ZNF280B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding IBA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF280B: view
genes like me logo Genes that share phenotypes with ZNF280B: view

Animal Model Products

CRISPR Products

miRNA for ZNF280B Gene

miRTarBase miRNAs that target ZNF280B

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF280B Gene

Localization for ZNF280B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF280B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF280B Gene COMPARTMENTS Subcellular localization image for ZNF280B gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZNF280B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF280B: view

Pathways & Interactions for ZNF280B Gene

SuperPathways for ZNF280B Gene

No Data Available

Interacting Proteins for ZNF280B Gene

Gene Ontology (GO) - Biological Process for ZNF280B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0007411 axon guidance IBA --
GO:0045892 negative regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF280B: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF280B Gene

Drugs & Compounds for ZNF280B Gene

No Compound Related Data Available

Transcripts for ZNF280B Gene

Unigene Clusters for ZNF280B Gene

Zinc finger protein 280B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF280B Gene

No ASD Table

Relevant External Links for ZNF280B Gene

GeneLoc Exon Structure for
ZNF280B
ECgene alternative splicing isoforms for
ZNF280B

Expression for ZNF280B Gene

mRNA expression in normal human tissues for ZNF280B Gene

mRNA differential expression in normal tissues according to GTEx for ZNF280B Gene

This gene is overexpressed in Testis (x11.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF280B Gene



NURSA nuclear receptor signaling pathways regulating expression of ZNF280B Gene:

ZNF280B

SOURCE GeneReport for Unigene cluster for ZNF280B Gene:

Hs.43834
genes like me logo Genes that share expression patterns with ZNF280B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ZNF280B Gene

Orthologs for ZNF280B Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF280B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF280B 34
  • 85.99 (n)
  • 79.27 (a)
dog
(Canis familiaris)
Mammalia ZNF280B 34
  • 87.61 (n)
  • 81.78 (a)
mouse
(Mus musculus)
Mammalia Zfp280b 34
  • 76.05 (n)
  • 71.02 (a)
Zfp280b 16
chimpanzee
(Pan troglodytes)
Mammalia ZNF280B 34
  • 99.69 (n)
  • 99.26 (a)
rat
(Rattus norvegicus)
Mammalia Zfp280b 34
  • 72.42 (n)
  • 67.87 (a)
Species where no ortholog for ZNF280B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF280B Gene

ENSEMBL:
Gene Tree for ZNF280B (if available)
TreeFam:
Gene Tree for ZNF280B (if available)

Paralogs for ZNF280B Gene

Paralogs for ZNF280B Gene

(4) SIMAP similar genes for ZNF280B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZNF280B: view

Variants for ZNF280B Gene

Sequence variations from dbSNP and Humsavar for ZNF280B Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs2236729 - 22,488,632(+) CATTT(G/T)CCCTA intron-variant, nc-transcript-variant, reference, missense
rs12484816 - 22,487,834(+) TGCTC(A/C)CAGTT intron-variant, nc-transcript-variant, reference, missense
rs13057545 -- 22,497,124(+) GGGAT(C/T)TACTC intron-variant
rs13058551 -- 22,497,097(+) acagg(C/G)gtgag intron-variant
rs16988995 -- 22,487,632(+) ATCTT(A/G)TTTAA intron-variant, nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF280B Gene

Variant ID Type Subtype PubMed ID
dgv23n14 CNV loss 18776910
dgv38n64 CNV loss 17921354
dgv39n64 CNV loss 17921354
dgv4505n100 CNV loss 25217958
dgv4506n100 CNV loss 25217958
dgv4507n100 CNV loss 25217958
dgv4510n100 CNV loss 25217958
dgv4511n100 CNV gain 25217958
dgv548n27 CNV loss 19166990
dgv550n27 CNV loss 19166990
dgv551n27 CNV loss 19166990
dgv555n27 CNV loss 19166990
dgv556n27 CNV loss 19166990
dgv557n27 CNV loss 19166990
dgv558n27 CNV loss 19166990
dgv731n67 CNV loss 20364138
dgv8004n54 CNV loss 21841781
dgv8005n54 CNV loss 21841781
dgv8010n54 CNV loss 21841781
dgv8011n54 CNV loss 21841781
dgv8012n54 CNV loss 21841781
dgv8013n54 CNV loss 21841781
dgv8014n54 CNV loss 21841781
dgv8015n54 CNV loss 21841781
dgv826e214 CNV loss 21293372
esv1007524 CNV gain 20482838
esv2422480 CNV deletion 17116639
esv33016 CNV gain 17666407
esv3568289 CNV loss 25503493
esv3647367 CNV loss 21293372
esv3647368 CNV loss 21293372
esv3893451 CNV loss 25118596
nsv1059960 CNV loss 25217958
nsv1060145 CNV gain 25217958
nsv1063128 CNV gain+loss 25217958
nsv438338 CNV loss 16468122
nsv459421 CNV gain 19166990
nsv459450 CNV loss 19166990
nsv459538 CNV loss 19166990
nsv459539 CNV loss 19166990
nsv459546 CNV loss 19166990
nsv459548 CNV loss 19166990
nsv469735 CNV loss 16826518
nsv474491 CNV novel sequence insertion 20440878
nsv479817 CNV novel sequence insertion 20440878
nsv479962 CNV novel sequence insertion 20440878
nsv481189 CNV novel sequence insertion 20440878
nsv481271 CNV novel sequence insertion 20440878
nsv508727 CNV insertion 20534489
nsv511072 OTHER complex 20534489
nsv514963 CNV gain+loss 21397061
nsv526328 CNV gain 19592680
nsv588348 CNV gain 21841781
nsv588431 CNV loss 21841781
nsv588468 CNV loss 21841781
nsv588469 CNV loss 21841781
nsv588470 CNV loss 21841781
nsv588472 CNV loss 21841781
nsv7350 OTHER inversion 18451855
nsv817937 CNV loss 17921354
nsv817953 CNV gain 17921354
nsv817956 CNV loss 17921354
nsv817957 CNV gain 17921354
nsv817958 CNV gain 17921354
nsv819428 CNV gain 19587683
nsv821694 CNV loss 15273396
nsv828977 CNV loss 20364138
nsv828979 CNV gain+loss 20364138
nsv834149 CNV loss 17160897
nsv834150 CNV loss 17160897

Variation tolerance for ZNF280B Gene

Residual Variation Intolerance Score: 73.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.77; 33.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF280B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF280B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF280B Gene

Disorders for ZNF280B Gene

Relevant External Links for ZNF280B

Genetic Association Database (GAD)
ZNF280B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF280B

No disorders were found for ZNF280B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF280B Gene

Publications for ZNF280B Gene

  1. One-megabase sequence analysis of the human immunoglobulin lambda gene locus. (PMID: 9074928) Kawasaki K. … Shimizu N. (Genome Res. 1997) 2 3 4 65
  2. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. (PMID: 22219177) Tao S. … Sun J. (Carcinogenesis 2012) 3 46 65
  3. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4 65
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  5. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4 65

Products for ZNF280B Gene

Sources for ZNF280B Gene

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