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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF280B Gene

protein-coding   GIFtS: 43
GCID: GC22M022838

Zinc Finger Protein 280B

(Previous names: zinc finger protein 279, suppressor of hairy wing homolog...)
(Previous symbols: ZNF279, SUHW2)
  Search for ZNF280B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 280B1 2     Zinc Finger Protein 6322 3
Zinc Finger Protein 2791 2 3     5'OY11.12 3
SUHW21 2 3     ZNF6322 3
ZNF2791 2 3     Suppressor Of Hairy Wing Homolog 2 (Drosophila)1
Suppressor Of Hairy Wing Homolog 22 3     D87009.C22.32

External Ids:    HGNC: 230221   Entrez Gene: 1408832   Ensembl: ENSG000001984777   UniProtKB: Q86YH23   

Export aliases for ZNF280B gene to outside databases

Previous GC identifers: GC22M021168 GC22M005797


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ZNF280B Gene:
This gene was identified by homology to other species. Its encoded protein is approximately 78-88% identical to a
predicted sheep protein of unknown function. The protein is also approximately 25% identical to the Drosophila
protein suppressor of hairy wing, which is a leucine zipper protein that represses the function of
transcriptional enhancers of the gypsy retrotransposon. (provided by RefSeq, Jul 2008)

GeneCards Summary for ZNF280B Gene: 
ZNF280B (zinc finger protein 280B) is a protein-coding gene. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF280A.

UniProtKB/Swiss-Prot: Z280B_HUMAN, Q86YH2
Function: May function as a transcription factor




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NT_011520.12  NC_018933.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF280B gene promoter:
         c-Fos   AhR   AP-1   GCNF   Tal-1beta   GCNF-1   c-Jun   Pax-4a   ITF-2   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF280B promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF280B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF280B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.22   Ensembl cytogenetic band:  22q11.22   HGNC cytogenetic band: 22q11.2

ZNF280B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF280B gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M022838:  view genomic region     (about GC identifiers)

Start:
22,838,767 bp from pter      End:
22,863,505 bp from pter
Size:
24,739 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: Z280B_HUMAN, Q86YH2 (See protein sequence)
Recommended Name: Zinc finger protein 280B  
Size: 543 amino acids; 61584 Da
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=BAA20005.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Explore the universe of human proteins at neXtProt for ZNF280B: NX_Q86YH2

Explore proteomics data for ZNF280B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86YH2

  • ZNF280B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF280B Protein Expression
    REFSEQ proteins: NP_542942.1  
    ENSEMBL proteins: 
     ENSP00000385998   ENSP00000353586  

    Human Recombinant Protein Products for ZNF280B: 
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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for ZNF280B 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    ZNF280B for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR025243 DUF4195
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q86YH2

    ProtoNet protein and cluster: Q86YH2

    UniProtKB/Swiss-Prot: Z280B_HUMAN, Q86YH2
    Similarity: Contains 4 C2H2-type zinc fingers


    ZNF280B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: Z280B_HUMAN, Q86YH2
    Function: May function as a transcription factor

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF280B for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF280B:
     Decreased Wnt reporter activit 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF280B

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ZNF280B (ENSP000003535864) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF280B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF280B (Z280B)

    Search CenterWatch for drugs/clinical trials and news about ZNF280B / Z280B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF280B gene: 
    NM_080764.2  

    Unigene Cluster for ZNF280B:

    Zinc finger protein 280B
    Hs.43834  [show with all ESTs]
    Unigene Representative Sequence: NM_080764
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000406426 ENST00000360412(uc002zwc.1)
    miRNA
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    8/62 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNF280B (see all 62):
    hsa-miR-4317 hsa-let-7d hsa-miR-4272 hsa-miR-106a hsa-miR-30d hsa-let-7g hsa-miR-4314 hsa-miR-30a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF280B

    Additional mRNA sequence: 

    AK097608.1 BC035376.1 BC040020.2 BC042370.1 CR456614.1 

    8 DOTS entries:

    DT.99935525  DT.442827  DT.211308  DT.120677192  DT.95097084  DT.100735577  DT.120678017  DT.95364568 

    24/64 AceView cDNA sequences (see all 64):

    AW663885 N26665 BI492558 N31273 AA333348 CB156631 BQ221117 NM_080764 
    AA923227 CB133948 W31789 AW104458 BE501238 BC035376 AA760995 BX093302 
    AA868010 N36258 BX108144 AI688190 AI126068 BI828153 AA737071 BX492870 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF280B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZNF280B Expression
    About this image


    See ZNF280B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF280B

    SOURCE GeneReport for Unigene cluster: Hs.43834
        SABiosciences Custom PCR Arrays for ZNF280B
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF280B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ZNF280B gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp280b1 , 5 zinc finger protein 280B1, 5 75.38(n)1
    69.23(a)1
      10 (38.67 cM)5
    644531  NM_177475.31  NP_803426.21 
     760326125 
    chicken
    (Gallus gallus)
    Aves --
    --
    25(a)
    1 → many
    10(7094684-7137592)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    23(a)
    1 → many
    GL343573.1(438826-450503)
    fruit fly
    (Drosophila melanogaster)
    Insecta row6
    relative of woc
    8(a)
    1 → many
    2R(11094032-11101137)
    worm
    (Caenorhabditis elegans)
    Secernentea F37D6.26
    Protein F37D6.2, isoform b
    14(a)
    1 → many
    I(10475522-10478129)


    ENSEMBL Gene Tree for ZNF280B (if available)
    TreeFam Gene Tree for ZNF280B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF280B gene
    ZNF280A2  ZNF280D2  POGZ2  ZNF280C2  
    4 SIMAP similar genes for ZNF280B using alignment to 1 protein entry:     Z280B_HUMAN:
    ZNF280A    ZNF280D    ZNF280C    POGZ

    ZNF280B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/601 SNPs in ZNF280B are shown (see all 601)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1494686431,2
    --22838304(+) TGACAA/GAGCGA 1 -- ds50010--------
    rs3938291,2
    C,H--22838416(+) AATTAC/AAAACT 1 -- ds500112Minor allele frequency- A:0.16NA WA CSA EA 375
    rs1439505941,2
    --22838554(+) AAAAGC/TACAAA 1 -- ds50010--------
    rs1398807381,2
    C--22838617(+) CACTTC/GAACTC 1 -- ds50010--------
    rs1893360851,2
    --22838684(+) CAGAGA/CGAGAC 1 -- ds50010--------
    rs1430486891,2
    C--22838705(+) AAAAC-/AAAACA 1 -- ds50010--------
    rs3889211,2
    C,F,A,H--22838738(+) GGAAAA/GACAAT 1 -- ds500113Minor allele frequency- G:0.30NS EA NA 1952
    rs559339241,2
    C--22838738(+) GGAAA-/GACA  
     ATACAGC
    AACAA
    1 -- ds50011Minor allele frequency- GACAATACAGC:0.00NA 2
    rs1817536821,2
    --22838924(+) TATTCA/GATATA 1 -- ut310--------
    rs4147811,2
    C,F,O,H--22839096(+) TGATGA/CTGATC 1 -- ut3128Minor allele frequency- C:0.18NS EA NA WA CSA 2439

    HapMap Linkage Disequilibrium report for ZNF280B (22838767 - 22863505 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/40 variations for ZNF280B (see all 40):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2422480CNV Deletion17116639
    nsv508727CNV Insertion20534489
    nsv817956CNV Loss17921354
    nsv459546CNV Loss19166990
    nsv834150CNV Loss17160897
    nsv469735CNV Loss16826518
    dgv551n27CNV Loss19166990
    nsv817937CNV Loss17921354
    dgv39n64CNV Loss17921354
    dgv38n64CNV Loss17921354

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZNF280B for disorders           About MalaCards

    ZNF280B for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZNF280B

    Export disorders for ZNF280B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF280B gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF280B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. One-megabase sequence analysis of the human immunoglobulin lambda gene locus. (PubMed id 9074928)1, 2, 3 Kawasaki K....Shimizu N. (1997)
    2. A genome-wide search for loci interacting with known p rostate cancer risk-associated genetic variants. (PubMed id 22219177)1, 4 Tao S....Sun J. (2012)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
    5. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
    6. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    7. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (2009)
    8. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 140883 HGNC: 23022 AceView: SUHW2 Ensembl:ENSG00000198477 euGenes: HUgn140883
    ECgene: ZNF280B H-InvDB: ZNF280B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF280B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF280B gene:
    Search GeneIP for patents involving ZNF280B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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