Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF280B Gene

Aliases for ZNF280B Gene

  • Zinc Finger Protein 280B 2 3
  • Zinc Finger Protein 279 2 3 4
  • Suppressor Of Hairy Wing Homolog 2 3 4
  • Zinc Finger Protein 632 3 4
  • 5OY11.1 3 4
  • ZNF279 3 4
  • ZNF632 3 4
  • SUHW2 3 4
  • Suppressor Of Hairy Wing Homolog 2 (Drosophila) 2
  • D87009.C22.3 3

External Ids for ZNF280B Gene

Previous HGNC Symbols for ZNF280B Gene

  • ZNF279
  • SUHW2

Previous GeneCards Identifiers for ZNF280B Gene

  • GC22M021168
  • GC22M022838
  • GC22M005797

Summaries for ZNF280B Gene

Entrez Gene Summary for ZNF280B Gene

  • The protein encoded by this gene is a transcription factor that upregulates expression of MDM2, which negatively regulates p53 expression. This gene is highly expressed in prostate cancer cells, which leads to a reduction in p53 levels and an increase in growth of the cancer cells. Several transcript variants have been found for this gene, but only one of them is protein-coding. [provided by RefSeq, Jan 2015]

GeneCards Summary for ZNF280B Gene

ZNF280B (Zinc Finger Protein 280B) is a Protein Coding gene.

UniProtKB/Swiss-Prot for ZNF280B Gene

  • May function as a transcription factor

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF280B Gene

Genomics for ZNF280B Gene

Regulatory Elements for ZNF280B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF280B Gene

Start:
22,484,421 bp from pter
End:
22,509,187 bp from pter
Size:
24,767 bases
Orientation:
Minus strand

Genomic View for ZNF280B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF280B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF280B Gene

Proteins for ZNF280B Gene

  • Protein details for ZNF280B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YH2-Z280B_HUMAN
    Recommended name:
    Zinc finger protein 280B
    Protein Accession:
    Q86YH2
    Secondary Accessions:

    Protein attributes for ZNF280B Gene

    Size:
    543 amino acids
    Molecular mass:
    61584 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA20005.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for ZNF280B Gene

Proteomics data for ZNF280B Gene at MOPED

Post-translational modifications for ZNF280B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF280B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF280B Gene

Domains for ZNF280B Gene

Protein Domains for ZNF280B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF280B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86YH2

UniProtKB/Swiss-Prot:

Z280B_HUMAN :
  • Q86YH2
Similarity:
  • Contains 4 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF280B: view

No data available for Gene Families for ZNF280B Gene

Function for ZNF280B Gene

Molecular function for ZNF280B Gene

UniProtKB/Swiss-Prot Function: May function as a transcription factor

Gene Ontology (GO) - Molecular Function for ZNF280B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF280B: view

Phenotypes for ZNF280B Gene

GenomeRNAi human phenotypes for ZNF280B:
genes like me logo Genes that share phenotypes with ZNF280B: view

Animal Model Products

CRISPR Products

miRNA for ZNF280B Gene

miRTarBase miRNAs that target ZNF280B

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF280B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF280B Gene

Localization for ZNF280B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF280B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF280B Gene COMPARTMENTS Subcellular localization image for ZNF280B gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for ZNF280B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF280B: view

Pathways for ZNF280B Gene

SuperPathways for ZNF280B Gene

No Data Available

Interacting Proteins for ZNF280B Gene

Gene Ontology (GO) - Biological Process for ZNF280B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF280B: view

No data available for Pathways by source for ZNF280B Gene

Transcripts for ZNF280B Gene

Unigene Clusters for ZNF280B Gene

Zinc finger protein 280B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF280B

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ZNF280B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF280B Gene

No ASD Table

Relevant External Links for ZNF280B Gene

GeneLoc Exon Structure for
ZNF280B
ECgene alternative splicing isoforms for
ZNF280B

Expression for ZNF280B Gene

mRNA expression in normal human tissues for ZNF280B Gene

mRNA differential expression in normal tissues according to GTEx for ZNF280B Gene

This gene is overexpressed in Testis (11.2).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for ZNF280B Gene

SOURCE GeneReport for Unigene cluster for ZNF280B Gene Hs.43834

genes like me logo Genes that share expressions with ZNF280B: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ZNF280B Gene

Orthologs for ZNF280B Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF280B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF280B 35
  • 99.69 (n)
  • 99.26 (a)
cow
(Bos Taurus)
Mammalia ZNF280B 35
  • 85.99 (n)
  • 79.27 (a)
dog
(Canis familiaris)
Mammalia ZNF280B 35
  • 87.61 (n)
  • 81.78 (a)
mouse
(Mus musculus)
Mammalia Zfp280b 35
  • 76.05 (n)
  • 71.02 (a)
Zfp280b 16
rat
(Rattus norvegicus)
Mammalia Zfp280b 35
  • 72.42 (n)
  • 67.87 (a)
Species with no ortholog for ZNF280B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF280B Gene

ENSEMBL:
Gene Tree for ZNF280B (if available)
TreeFam:
Gene Tree for ZNF280B (if available)

Paralogs for ZNF280B Gene

Selected SIMAP similar genes for ZNF280B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZNF280B: view

No data available for Paralogs for ZNF280B Gene

Variants for ZNF280B Gene

Sequence variations from dbSNP and Humsavar for ZNF280B Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs11109 -- 22,487,881(+) TCCAG(C/T)GACAC synonymous-codon, reference
rs361651 -- 22,510,405(+) ATTAC(A/G)GCTAG upstream-variant-2KB
rs361676 -- 22,507,724(+) CTATG(C/T)TTCAG intron-variant
rs361901 -- 22,507,676(+) CAAAC(A/G)CATCA intron-variant
rs361907 -- 22,508,495(+) ACCTG(C/G)TTCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF280B Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER Inversion 18451855
nsv526328 CNV Gain 19592680
nsv459421 CNV Gain 19166990
nsv817937 CNV Loss 17921354
dgv548n27 CNV Loss 19166990
nsv459450 CNV Loss 19166990
esv2422480 CNV Deletion 17116639
nsv828977 CNV Loss 20364138
nsv828979 CNV Gain+Loss 20364138
dgv731n67 CNV Loss 20364138
dgv550n27 CNV Loss 19166990
dgv38n64 CNV Loss 17921354
dgv551n27 CNV Loss 19166990
nsv438338 CNV Loss 16468122
nsv834149 CNV Loss 17160897
esv1007524 CNV Gain 20482838
nsv469735 CNV Loss 16826518
dgv39n64 CNV Loss 17921354
dgv23n14 CNV Loss 18776910
dgv555n27 CNV Loss 19166990
dgv556n27 CNV Loss 19166990
dgv557n27 CNV Loss 19166990
dgv558n27 CNV Loss 19166990
nsv819428 CNV Gain 19587683
nsv514963 CNV Complex 21397061
nsv817953 CNV Gain 17921354
nsv834150 CNV Loss 17160897
nsv817956 CNV Loss 17921354
nsv459538 CNV Loss 19166990
nsv459539 CNV Loss 19166990
nsv821694 CNV Loss 15273396
nsv817957 CNV Gain 17921354
nsv915211 CNV Loss 21882294
nsv459546 CNV Loss 19166990
nsv817958 CNV Gain 17921354
nsv915212 CNV Gain 21882294
nsv508727 CNV Insertion 20534489
nsv511072 CNV Complex 20534489
nsv459548 CNV Loss 19166990
esv33016 CNV Gain 17666407

Relevant External Links for ZNF280B Gene

HapMap Linkage Disequilibrium report
ZNF280B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF280B Gene

Disorders for ZNF280B Gene

Relevant External Links for ZNF280B

Genetic Association Database (GAD)
ZNF280B
genes like me logo Genes that share disorders with ZNF280B: view

No data available for UniProtKB/Swiss-Prot for ZNF280B Gene

Publications for ZNF280B Gene

  1. One-megabase sequence analysis of the human immunoglobulin lambda gene locus. (PMID: 9074928) Kawasaki K. … Shimizu N. (Genome Res. 1997) 2 3 4
  2. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4
  3. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. (PMID: 22219177) Tao S. … Sun J. (Carcinogenesis 2012) 3 48
  4. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ZNF280B Gene

Sources for ZNF280B Gene

Back to Top

Content