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ZNF280A Gene

protein-coding   GIFtS: 39
GCID: GC22M022868

Zinc Finger Protein 280A

(Previous names: zinc finger protein 280, suppressor of hairy wing homolog...)
(Previous symbols: ZNF280, SUHW1)
  Search for ZNF280A
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 280A1 2     Zinc Finger Protein 6362 3
SUHW11 2 3     3'OY11.12 3
ZNF2801 2 3     ZNF6362 3
Zinc Finger Protein 2801 2     Suppressor Of Hairy Wing Homolog 1 (Drosophila)1
Suppressor Of Hairy Wing Homolog 12 3     

External Ids:    HGNC: 185971   Entrez Gene: 1290252   Ensembl: ENSG000001695487   UniProtKB: P598173   

Export aliases for ZNF280A gene to outside databases

Previous GC identifers: GC22M021198 GC22M005826


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ZNF280A Gene:
This gene was predicted both by automated computational analysis and by similarity to a Drosophila gene and to
predicted genes in other species (sheep, chimp, dog, cow). The predicted protein of this gene is similar to
Drosophila suppressor of hairy wing protein, a leucine zipper protein which represses the function of
transcriptional enhancers of the gypsy retrotransposon. (provided by RefSeq, Jul 2008)

GeneCards Summary for ZNF280A Gene:
ZNF280A (zinc finger protein 280A) is a protein-coding gene. An important paralog of this gene is ZNF280D.

UniProtKB/Swiss-Prot: Z280A_HUMAN, P59817
Function: May function as a transcription factor




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000022.11  NC_018933.2  NT_011520.13  NT_187629.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF280A gene promoter:
         HOXA9B   HOXA9   AhR   PPAR-alpha   AML1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF280A promoter sequence
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF280A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.22   Ensembl cytogenetic band:  22q11.22   HGNC cytogenetic band: 22q11.21

ZNF280A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF280A gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M022868:  view genomic region     (about GC identifiers)

Start:
22,868,060 bp from pter      End:
22,874,613 bp from pter
Size:
6,554 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: Z280A_HUMAN, P59817 (See protein sequence)
Recommended Name: Zinc finger protein 280A  
Size: 542 amino acids; 60816 Da

Explore the universe of human proteins at neXtProt for ZNF280A: NX_P59817

Explore proteomics data for ZNF280A at MOPED


See ZNF280A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_542778.1  
ENSEMBL proteins: 
 ENSP00000302855  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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3 InterPro protein domains:
 IPR025243 DUF4195
 IPR015880 Znf_C2H2-like
 IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry P59817

ProtoNet protein and cluster: P59817

UniProtKB/Swiss-Prot: Z280A_HUMAN, P59817
Similarity: Contains 4 C2H2-type zinc fingers


ZNF280A for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: Z280A_HUMAN, P59817
Function: May function as a transcription factor

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003677DNA binding IEA--
GO:0046872metal ion binding IEA--
     
ZNF280A for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for ZNF280A:
 Decreased viability of wild-ty 

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
Z280A_HUMAN, P59817: Nucleus (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus3

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--

ZNF280A for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Interactions:

    Search GeneGlobe Interaction Network for ZNF280A

Gene Ontology (GO): 2 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006351transcription, DNA-templated IEA--
GO:0006355regulation of transcription, DNA-templated IEA--

ZNF280A for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for ZNF280A (Z280A)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for ZNF280A gene: 
NM_080740.3  

Unigene Cluster for ZNF280A:

Zinc finger protein 280A
Hs.178665  [show with all ESTs]
Unigene Representative Sequence: BC053901
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000302097(uc002zwe.3)
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Additional mRNA sequence: 

AK093108.1 BC053901.1 

1 DOTS entry:

DT.100021335 

8 AceView cDNA sequences:

AK093108 NM_080740 BC053901 AA558468 BU177839 BU735583 BM697104 BG473533 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ZNF280A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
ZNF280A Expression
About this image

ZNF280A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

ZNF280A Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.178665
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for ZNF280A gene from Selected species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
dog
(Canis familiaris)
Mammalia ZNF280A1 zinc finger protein 280A 74.71(n)
60.24(a)
  100688648  XM_005642440.1  XP_005642497.1 
chicken
(Gallus gallus)
Aves --
Uncharacterized protein
25(a)
1 → many
10(7094684-7137592)
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
22(a)
1 → many
GL343573.1(438826-450503)
zebrafish
(Danio rerio)
Actinopterygii znf280d6
zinc finger protein 280D
22(a)
1 → many
7(54171798-54206632) ENSDARG00000077013
fruit fly
(Drosophila melanogaster)
Insecta row6
relative of woc
9(a)
1 → many
2R(11094032-11101137)
worm
(Caenorhabditis elegans)
Secernentea F37D6.26
Protein F37D6.2, isoform b (F37D6.2) mRNA, complet...
16(a)
1 → many
I(10475522-10478129) WBGene00009508


ENSEMBL Gene Tree for ZNF280A (if available)
TreeFam Gene Tree for ZNF280A (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for ZNF280A gene
ZNF280D2  POGZ2  ZNF280C2  ZNF280B2  
4 SIMAP similar genes for ZNF280A using alignment to 1 protein entry:     Z280A_HUMAN:
ZNF280B    ZNF280D    POGZ    ZNF280C

ZNF280A for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for ZNF280A
PGOHUM00000244047


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ZNF280A (see all 330)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 22 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs3617171,2
C,F,A,H--22867703(+) acagcG/Aaaaat 1 -- ds500110Minor allele frequency- A:0.46NA WA CSA EA 372
rs1820404551,2
--22867788(+) GGCGCA/GATCTC 1 -- ds50010--------
rs3618221,2
C--22867808(+) AAACTC/-CCCCC 1 -- ds50011Minor allele frequency- -:0.00NA 2
rs1428315881,2
--22867837(+) CTCCTC/GCCTCA 1 -- ds50010--------
rs57585651,2
C,F--22867870(+) caggcG/Acccac 1 -- ds50011Minor allele frequency- A:0.50CSA 2
rs1141106171,2
F--22867899(+) TTTCTA/GTTTTA 1 -- ds50011Minor allele frequency- G:0.06WA 118
rs3617351,2
C,F--22867956(+) ctgacG/Cccaag 1 -- ds500112Minor allele frequency- C:0.48NA WA CSA EA 375
rs3615951,2
C,A,H--22868017(+) atcacG/Acccag 1 -- ds50018Minor allele frequency- A:0.45NA CSA WA 250
rs1850573361,2
--22868057(+) CAAGAA/GTCTTT 1 -- ds50010--------
rs3617781,2
C,F,A,H--22868090(+) ttcatG/Aaacaa 1 -- ut3111Minor allele frequency- A:0.48MN NA WA CSA EA 556

HapMap Linkage Disequilibrium report for ZNF280A (22868060 - 22874613 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for ZNF280A (see all 40):    About this table    
Variant IDTypeSubtypePubMed ID
esv2422480CNV Deletion17116639
nsv194CNV Insertion15895083
nsv508727CNV Insertion20534489
nsv3571CNV Insertion18451855
nsv834150CNV Loss17160897
nsv469735CNV Loss16826518
dgv551n27CNV Loss19166990
dgv4899n71CNV Loss21882294
nsv817937CNV Loss17921354
dgv39n64CNV Loss17921354

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for ZNF280A gene integrated from 10 sources:
(articles sorted by number of sources associating them with ZNF280A)
    Utopia: connect your pdf to the dynamic
world of online information

  1. One-megabase sequence analysis of the human immunoglobulin lambda gene locus. (PubMed id 9074928)1, 2, 3 Kawasaki K.... Shimizu N. (Genome Res. 1997)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  3. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I.... Wright H. (Nature 1999)
  4. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
  6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 129025 HGNC: 18597 AceView: SUHW1 Ensembl:ENSG00000169548 euGenes: HUgn129025
ECgene: ZNF280A H-InvDB: ZNF280A

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ZNF280A Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ZNF280A gene:
Search GeneIP for patents involving ZNF280A

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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