ZNF280A Gene
protein-coding GIFtS: 38
GCID: GC22M022868
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zinc finger protein 280A(Previous names: zinc finger protein 280, suppressor of hairy wing homolog...)
(Previous symbols: ZNF280, SUHW1)
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Aliases
for ZNF280A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 280A1 2 | | Zinc Finger Protein 2801 2 | | 3'OY11.11 2 3 | | Suppressor Of Hairy Wing Homolog 12 3 | | SUHW11 2 3 | | Zinc Finger Protein 6362 3 | | ZNF2801 2 3 | | Suppressor Of Hairy Wing Homolog 1 (Drosophila)1 | | ZNF6361 2 3 | | |
Export aliases for ZNF280A gene to outside databasesPrevious GC identifers: GC22M021198 GC22M005826 |
Summaries
for ZNF280A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ZNF280A:
This gene was predicted both by automated computational analysis and by similarity to a Drosophila gene and topredicted genes in other species (sheep, chimp, dog, cow). The predicted protein of this gene is similar to Drosophilasuppressor of hairy wing protein, a leucine zipper protein which represses the function of transcriptional enhancersof the gypsy retrotransposon. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: Z280A_HUMAN, P59817Function: May function as a transcription factor
|
Genomic Views
for ZNF280A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011520.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF280A gene promoter:
HOXA9B HOXA9 AhR PPAR-alpha AML1a Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF280A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF280A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q11.22 Ensembl cytogenetic band: 22q11.22 HGNC cytogenetic band: 22q11.21ZNF280A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22M022868: view genomic region
(about GC identifiers)
Start:
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22,868,060 bp from pter |
End:
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22,874,613 bp from pter |
Size:
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6,554 bases |
Orientation:
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minus strand |
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Proteins
for ZNF280A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: Z280A_HUMAN, P59817 (See
protein sequence)Recommended Name: Zinc finger protein 280A Size: 542 amino acids; 60816 Da
Subcellular location: Nucleus (Potential)Explore the universe of human proteins at neXtProt for ZNF280A: NX_P59817
ZNF280A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_542778.1
ENSEMBL proteins: ENSP00000302855
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
ZNF280A for ontologies About GeneDecksing
ZNF280A Antibody Products:
Assay Products for ZNF280A: |
Protein
Domains /
Families
for ZNF280A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF280A for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P59817ProtoNet protein and cluster: P59817 UniProtKB/Swiss-Prot: Z280A_HUMAN, P59817Similarity: Contains 4 C2H2-type zinc fingers |
Function
for ZNF280A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: Z280A_HUMAN, P59817Function: May function as a transcription factor
Clone
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF280A |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
ZNF280A for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ZNF280A:
|
Pathways & Interactions
for ZNF280A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF280A
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF280A for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF280A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF280A
Search CenterWatch for drugs/clinical trials and news about ZNF280A / Z280A
|
Transcripts
for ZNF280A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF280A gene: NM_080740.3 Unigene Cluster for ZNF280A: Zinc finger protein 280A Hs.178665 [show with all ESTs]Unigene Representative Sequence: BC0539011 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000302097(uc002zwe.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF280A
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF280A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF280A (NM_080740) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF280A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF280A |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF280A
Browse OriGene validated miRNA SYBR primer pairs
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Additional cDNA sequence: AK093108.1 BC053901.1 1 DOTS entry: DT.100021335 8 AceView cDNA sequences: AK093108 NM_080740 BC053901 AA558468 BM697104 BU177839 BU735583 BG473533
GeneLoc Exon Structure
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Expression
for ZNF280A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF280A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See ZNF280A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF280A
SOURCE GeneReport for Unigene cluster: Hs.178665
SABiosciences Custom PCR Arrays for ZNF280A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF280A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZNF280A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF280A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF280A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF280A |
Orthologs
for ZNF280A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ZNF280A gene from 3/12 species (see all 12) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
zebrafish
(Danio rerio) |
Actinopterygii |
znf280d6 |
zinc finger protein 280D |
21(a) |
1 → many |
7(54171798-54206632) |
fruit fly
(Drosophila melanogaster) |
Insecta |
row6 |
relative of woc |
7(a) |
1 → many |
2R(11094032-11101137) |
worm
(Caenorhabditis elegans) |
Secernentea |
F37D6.26 |
Protein F37D6.2, isoform a |
13(a) |
1 → many |
I(10475513-10478120) |
ENSEMBL Gene Tree for ZNF280A (if available)
TreeFam Gene Tree for ZNF280A (if available) |
Paralogs
for ZNF280A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF280A gene
- ZNF280D2 POGZ2 ZNF280B2 ZNF280C2
4 SIMAP similar genes for ZNF280A using alignment to 1 protein entry: Z280A_HUMAN:ZNF280B ZNF280D ZNF280C POGZ
ZNF280A for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ZNF280A
PGOHUM00000244047
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Genomic Variants
for ZNF280A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF280A (22868060 - 22874613 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 36 variations for ZNF280A
15/36 CNVs (see all 36): 59061 34540 5356 35997 35989 9835 2266 35998 5175 90927 0334 35987 35999 35996 53720 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF280A |
|
Disorders
/ Diseases
for ZNF280A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ZNF280A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF280A gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF280A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- One-megabase sequence analysis of the human immunoglobulin lambda gene locus. (PubMed id 9074928)1, 2, 3 Kawasaki K....Shimizu N. (1997)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for ZNF280A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing ZNF280A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF280A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF280A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF280A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF280A gene:
Search GeneIP for patents involving ZNF280A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF280A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | ZNF280A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF280A |
|  |  |  | | | | Search ThermoFisher Antibodies for ZNF280A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF280A |
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