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Aliases for ZNF280A Gene

Aliases for ZNF280A Gene

  • Zinc Finger Protein 280A 2 3 5
  • Suppressor Of Hairy Wing Homolog 1 3 4
  • Zinc Finger Protein 280 2 3
  • Zinc Finger Protein 636 3 4
  • 3OY11.1 3 4
  • ZNF280 3 4
  • ZNF636 3 4
  • SUHW1 3 4
  • Suppressor Of Hairy Wing Homolog 1 (Drosophila) 2

External Ids for ZNF280A Gene

Previous HGNC Symbols for ZNF280A Gene

  • ZNF280
  • SUHW1

Previous GeneCards Identifiers for ZNF280A Gene

  • GC22M021198
  • GC22M022868
  • GC22M005826

Summaries for ZNF280A Gene

Entrez Gene Summary for ZNF280A Gene

  • This gene encodes a zinc finger protein. The encoded protein contains 4 C2H2-type zinc fingers, which are commonly found in transcription factors. A variety of functions may be performed by this type of zinc finger protein, including the binding of DNA or RNA. [provided by RefSeq, Apr 2014]

GeneCards Summary for ZNF280A Gene

ZNF280A (Zinc Finger Protein 280A) is a Protein Coding gene. An important paralog of this gene is POGZ.

UniProtKB/Swiss-Prot for ZNF280A Gene

  • May function as a transcription factor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF280A Gene

Genomics for ZNF280A Gene

Regulatory Elements for ZNF280A Gene

Enhancers for ZNF280A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF280A on UCSC Golden Path with GeneCards custom track

Promoters for ZNF280A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF280A on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF280A Gene

22,513,736 bp from pter
22,520,281 bp from pter
6,546 bases
Minus strand

Genomic View for ZNF280A Gene

Genes around ZNF280A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF280A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF280A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF280A Gene

Proteins for ZNF280A Gene

  • Protein details for ZNF280A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 280A
    Protein Accession:

    Protein attributes for ZNF280A Gene

    542 amino acids
    Molecular mass:
    60816 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF280A Gene

Proteomics data for ZNF280A Gene at MOPED

Post-translational modifications for ZNF280A Gene

No Post-translational modifications

Other Protein References for ZNF280A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF280A Gene

Domains & Families for ZNF280A Gene

Protein Domains for ZNF280A Gene


Suggested Antigen Peptide Sequences for ZNF280A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 4 C2H2-type zinc fingers.
  • Contains 4 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF280A: view

No data available for Gene Families for ZNF280A Gene

Function for ZNF280A Gene

Molecular function for ZNF280A Gene

UniProtKB/Swiss-Prot Function:
May function as a transcription factor.
genes like me logo Genes that share phenotypes with ZNF280A: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF280A Gene

Localization for ZNF280A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF280A Gene

Subcellular locations from

Jensen Localization Image for ZNF280A Gene COMPARTMENTS Subcellular localization image for ZNF280A gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for ZNF280A Gene

Pathways & Interactions for ZNF280A Gene

SuperPathways for ZNF280A Gene

No Data Available

Interacting Proteins for ZNF280A Gene

Gene Ontology (GO) - Biological Process for ZNF280A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IBA --
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF280A: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF280A Gene

Drugs & Compounds for ZNF280A Gene

No Compound Related Data Available

Transcripts for ZNF280A Gene

mRNA/cDNA for ZNF280A Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF280A Gene

Zinc finger protein 280A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF280A Gene

No ASD Table

Relevant External Links for ZNF280A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF280A Gene

mRNA expression in normal human tissues for ZNF280A Gene

mRNA differential expression in normal tissues according to GTEx for ZNF280A Gene

This gene is overexpressed in Adrenal Gland (x34.3) and Testis (x5.0).

Protein differential expression in normal tissues from HIPED for ZNF280A Gene

This gene is overexpressed in Breast (68.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF280A Gene

SOURCE GeneReport for Unigene cluster for ZNF280A Gene Hs.178665

genes like me logo Genes that share expression patterns with ZNF280A: view

Protein tissue co-expression partners for ZNF280A Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ZNF280A Gene

Orthologs for ZNF280A Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF280A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZNF280A 35
  • 73.77 (n)
  • 58.49 (a)
ZNF280A 36
  • 57 (a)
(Canis familiaris)
Mammalia ZNF280A 35
  • 74.71 (n)
  • 60.24 (a)
(Pan troglodytes)
Mammalia ZNF280A 35
  • 98.83 (n)
  • 97.41 (a)
ZNF280A 36
  • 97 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 30 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 40 (a)
(Gallus gallus)
Aves -- 36
  • 25 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 22 (a)
(Danio rerio)
Actinopterygii znf280d 36
  • 22 (a)
fruit fly
(Drosophila melanogaster)
Insecta row 36
  • 9 (a)
(Caenorhabditis elegans)
Secernentea F37D6.2 36
  • 16 (a)
Species with no ortholog for ZNF280A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ZNF280A Gene

Gene Tree for ZNF280A (if available)
Gene Tree for ZNF280A (if available)

Paralogs for ZNF280A Gene

Paralogs for ZNF280A Gene

(4) SIMAP similar genes for ZNF280A Gene using alignment to 1 proteins: Pseudogenes for ZNF280A Gene

genes like me logo Genes that share paralogs with ZNF280A: view

Variants for ZNF280A Gene

Sequence variations from dbSNP and Humsavar for ZNF280A Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
VAR_028218 -
VAR_028219 -
VAR_028220 -
VAR_028221 -
VAR_028222 -

Structural Variations from Database of Genomic Variants (DGV) for ZNF280A Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER Inversion 18451855
nsv526328 CNV Gain 19592680
nsv459421 CNV Gain 19166990
nsv817937 CNV Loss 17921354
dgv548n27 CNV Loss 19166990
esv2422480 CNV Deletion 17116639
nsv828977 CNV Loss 20364138
nsv828979 CNV Gain+Loss 20364138
dgv731n67 CNV Loss 20364138
dgv550n27 CNV Loss 19166990
dgv38n64 CNV Loss 17921354
dgv551n27 CNV Loss 19166990
nsv438338 CNV Loss 16468122
nsv834149 CNV Loss 17160897
esv1007524 CNV Gain 20482838
nsv469735 CNV Loss 16826518
dgv39n64 CNV Loss 17921354
dgv23n14 CNV Loss 18776910
dgv555n27 CNV Loss 19166990
dgv556n27 CNV Loss 19166990
dgv557n27 CNV Loss 19166990
dgv558n27 CNV Loss 19166990
nsv819428 CNV Gain 19587683
nsv514963 CNV Complex 21397061
nsv834150 CNV Loss 17160897
nsv459539 CNV Loss 19166990
nsv821694 CNV Loss 15273396
nsv817957 CNV Gain 17921354
nsv915211 CNV Loss 21882294
nsv915212 CNV Gain 21882294
nsv508727 CNV Insertion 20534489
nsv511072 CNV Complex 20534489
nsv459548 CNV Loss 19166990
esv33016 CNV Gain 17666407
dgv4898n71 CNV Loss 21882294
nsv194 CNV Insertion 15895083
nsv3571 CNV Insertion 18451855
dgv560n27 CNV Loss 19166990
nsv433336 CNV Loss 18776910
dgv4899n71 CNV Loss 21882294

Variation tolerance for ZNF280A Gene

Residual Variation Intolerance Score: 89.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 18.44; 98.57% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF280A Gene

Disorders for ZNF280A Gene

Relevant External Links for ZNF280A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF280A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF280A Gene

Publications for ZNF280A Gene

  1. One-megabase sequence analysis of the human immunoglobulin lambda gene locus. (PMID: 9074928) Kawasaki K. … Shimizu N. (Genome Res. 1997) 2 3 4 67
  2. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M. … Stelzl U. (Nat. Methods 2013) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for ZNF280A Gene

Sources for ZNF280A Gene