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Aliases for ZNF280A Gene

Aliases for ZNF280A Gene

  • Zinc Finger Protein 280A 2 3 5
  • Suppressor Of Hairy Wing Homolog 1 3 4
  • Zinc Finger Protein 280 2 3
  • Zinc Finger Protein 636 3 4
  • 3OY11.1 3 4
  • ZNF280 3 4
  • ZNF636 3 4
  • SUHW1 3 4
  • Suppressor Of Hairy Wing Homolog 1 (Drosophila) 2

External Ids for ZNF280A Gene

Previous HGNC Symbols for ZNF280A Gene

  • ZNF280
  • SUHW1

Previous GeneCards Identifiers for ZNF280A Gene

  • GC22M021198
  • GC22M022868
  • GC22M005826

Summaries for ZNF280A Gene

Entrez Gene Summary for ZNF280A Gene

  • This gene encodes a zinc finger protein. The encoded protein contains 4 C2H2-type zinc fingers, which are commonly found in transcription factors. A variety of functions may be performed by this type of zinc finger protein, including the binding of DNA or RNA. [provided by RefSeq, Apr 2014]

GeneCards Summary for ZNF280A Gene

ZNF280A (Zinc Finger Protein 280A) is a Protein Coding gene. An important paralog of this gene is ZNF280B.

UniProtKB/Swiss-Prot for ZNF280A Gene

  • May function as a transcription factor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF280A Gene

Genomics for ZNF280A Gene

Regulatory Elements for ZNF280A Gene

Enhancers for ZNF280A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F022486 0.6 ENCODE 12.5 +33.3 33288 0.2 ZNF639 POLR2A ZNF280A ENSG00000226595 ZNF280B
GH22F022394 1.2 Ensembl ENCODE 11.9 +123.9 123906 3.7 SOX13 CTCF TBL1XR1 SAP130 BACH1 UBTF THRB RAD21 RARA YY1 ZNF280A IGLV7-43 IGLVI-42
GH22F022520 0.7 ENCODE 0.8 -0.1 -52 0.2 ELF3 TBP PKNOX1 ZNF133 ARID4B ZNF48 THAP11 ZNF263 NFYC USF2 ZNF280A PIR39122
GH22F022546 1.2 ENCODE 0.3 -26.3 -26323 0.1 ZNF341 MAX TSC22D4 MYC PIR39122 ZNF280A
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZNF280A on UCSC Golden Path with GeneCards custom track

Promoters for ZNF280A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for ZNF280A Gene

22,513,736 bp from pter
22,520,281 bp from pter
6,546 bases
Minus strand

Genomic View for ZNF280A Gene

Genes around ZNF280A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF280A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF280A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF280A Gene

Proteins for ZNF280A Gene

  • Protein details for ZNF280A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 280A
    Protein Accession:

    Protein attributes for ZNF280A Gene

    542 amino acids
    Molecular mass:
    60816 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF280A Gene

Post-translational modifications for ZNF280A Gene

No Post-translational modifications

Other Protein References for ZNF280A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF280A Gene

Domains & Families for ZNF280A Gene

Protein Domains for ZNF280A Gene

Suggested Antigen Peptide Sequences for ZNF280A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 4 C2H2-type zinc fingers.
  • Contains 4 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF280A: view

No data available for Gene Families for ZNF280A Gene

Function for ZNF280A Gene

Molecular function for ZNF280A Gene

UniProtKB/Swiss-Prot Function:
May function as a transcription factor.

Gene Ontology (GO) - Molecular Function for ZNF280A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding IBA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF280A: view
genes like me logo Genes that share phenotypes with ZNF280A: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF280A Gene

Localization for ZNF280A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF280A Gene

Subcellular locations from

Jensen Localization Image for ZNF280A Gene COMPARTMENTS Subcellular localization image for ZNF280A gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZNF280A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF280A: view

Pathways & Interactions for ZNF280A Gene

SuperPathways for ZNF280A Gene

No Data Available

Interacting Proteins for ZNF280A Gene

Gene Ontology (GO) - Biological Process for ZNF280A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007411 axon guidance IBA --
GO:0045892 negative regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF280A: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF280A Gene

Transcripts for ZNF280A Gene

mRNA/cDNA for ZNF280A Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF280A Gene

Zinc finger protein 280A:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF280A Gene

No ASD Table

Relevant External Links for ZNF280A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF280A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF280A Gene

mRNA differential expression in normal tissues according to GTEx for ZNF280A Gene

This gene is overexpressed in Adrenal Gland (x34.3) and Testis (x5.0).

Protein differential expression in normal tissues from HIPED for ZNF280A Gene

This gene is overexpressed in Breast (68.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF280A Gene

Protein tissue co-expression partners for ZNF280A Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF280A Gene:


SOURCE GeneReport for Unigene cluster for ZNF280A Gene:

genes like me logo Genes that share expression patterns with ZNF280A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ZNF280A Gene

Orthologs for ZNF280A Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF280A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF280A 34 35
  • 98.83 (n)
(Canis familiaris)
Mammalia ZNF280A 34
  • 74.71 (n)
(Bos Taurus)
Mammalia ZNF280A 34 35
  • 73.77 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 40 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 30 (a)
(Gallus gallus)
Aves -- 35
  • 25 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 22 (a)
(Danio rerio)
Actinopterygii znf280d 35
  • 22 (a)
fruit fly
(Drosophila melanogaster)
Insecta row 35
  • 9 (a)
(Caenorhabditis elegans)
Secernentea F37D6.2 35
  • 16 (a)
Species where no ortholog for ZNF280A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ZNF280A Gene

Gene Tree for ZNF280A (if available)
Gene Tree for ZNF280A (if available)

Paralogs for ZNF280A Gene

Paralogs for ZNF280A Gene

(4) SIMAP similar genes for ZNF280A Gene using alignment to 1 proteins: Pseudogenes for ZNF280A Gene

genes like me logo Genes that share paralogs with ZNF280A: view

Variants for ZNF280A Gene

Sequence variations from dbSNP and Humsavar for ZNF280A Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs10522734 -- 22,520,678(+) TCTCA(-/ATCTCA)CAGCC intron-variant, upstream-variant-2KB
rs111871430 -- 22,518,075(+) CGCCC(A/G)CCACC intron-variant
rs111918990 -- 22,521,291(+) CGTGC(A/G)TGCCT intron-variant, upstream-variant-2KB
rs112018562 -- 22,518,427(+) TATTG(-/T)TTTTC intron-variant
rs112110007 -- 22,516,171(+) AGCTA(A/C)TTGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF280A Gene

Variant ID Type Subtype PubMed ID
dgv23n14 CNV loss 18776910
dgv38n64 CNV loss 17921354
dgv39n64 CNV loss 17921354
dgv4505n100 CNV loss 25217958
dgv4506n100 CNV loss 25217958
dgv4507n100 CNV loss 25217958
dgv4510n100 CNV loss 25217958
dgv4511n100 CNV gain 25217958
dgv548n27 CNV loss 19166990
dgv550n27 CNV loss 19166990
dgv551n27 CNV loss 19166990
dgv555n27 CNV loss 19166990
dgv556n27 CNV loss 19166990
dgv557n27 CNV loss 19166990
dgv558n27 CNV loss 19166990
dgv560n27 CNV loss 19166990
dgv731n67 CNV loss 20364138
dgv8004n54 CNV loss 21841781
dgv8005n54 CNV loss 21841781
dgv8010n54 CNV loss 21841781
dgv8011n54 CNV loss 21841781
dgv8012n54 CNV loss 21841781
dgv8014n54 CNV loss 21841781
dgv8015n54 CNV loss 21841781
dgv826e214 CNV loss 21293372
esv1007524 CNV gain 20482838
esv2422480 CNV deletion 17116639
esv33016 CNV gain 17666407
esv3568289 CNV loss 25503493
esv3575435 CNV gain 25503493
esv3647368 CNV loss 21293372
nsv1059960 CNV loss 25217958
nsv1060145 CNV gain 25217958
nsv1063128 CNV gain+loss 25217958
nsv194 CNV insertion 15895083
nsv3571 CNV insertion 18451855
nsv433336 CNV loss 18776910
nsv438338 CNV loss 16468122
nsv459421 CNV gain 19166990
nsv459539 CNV loss 19166990
nsv459548 CNV loss 19166990
nsv469735 CNV loss 16826518
nsv508727 CNV insertion 20534489
nsv511072 OTHER complex 20534489
nsv514963 CNV gain+loss 21397061
nsv526328 CNV gain 19592680
nsv588348 CNV gain 21841781
nsv588469 CNV loss 21841781
nsv588470 CNV loss 21841781
nsv588472 CNV loss 21841781
nsv7350 OTHER inversion 18451855
nsv817937 CNV loss 17921354
nsv817957 CNV gain 17921354
nsv819428 CNV gain 19587683
nsv821694 CNV loss 15273396
nsv828977 CNV loss 20364138
nsv828979 CNV gain+loss 20364138
nsv834149 CNV loss 17160897
nsv834150 CNV loss 17160897

Variation tolerance for ZNF280A Gene

Residual Variation Intolerance Score: 89.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 18.44; 98.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF280A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF280A Gene

Disorders for ZNF280A Gene

Relevant External Links for ZNF280A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF280A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF280A Gene

Publications for ZNF280A Gene

  1. One-megabase sequence analysis of the human immunoglobulin lambda gene locus. (PMID: 9074928) Kawasaki K. … Shimizu N. (Genome Res. 1997) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4 64
  4. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M. … Stelzl U. (Nat. Methods 2013) 3 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 64

Products for ZNF280A Gene

Sources for ZNF280A Gene

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