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Aliases for ZNF28 Gene

Aliases for ZNF28 Gene

  • Zinc Finger Protein 28 2 3 5
  • Zinc Finger Protein KOX24 3 4
  • KOX24 3 4
  • Zinc Finger Protein 28 (KOX 24) 2

External Ids for ZNF28 Gene

Previous GeneCards Identifiers for ZNF28 Gene

  • GC19U990097
  • GC19M053665
  • GC19M057981
  • GC19M057995
  • GC19M057992
  • GC19M053300
  • GC19M049628

Summaries for ZNF28 Gene

GeneCards Summary for ZNF28 Gene

ZNF28 (Zinc Finger Protein 28) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF860.

UniProtKB/Swiss-Prot for ZNF28 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF28 Gene

Genomics for ZNF28 Gene

Regulatory Elements for ZNF28 Gene

Promoters for ZNF28 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF28 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF28 Gene

Chromosome:
19
Start:
52,797,408 bp from pter
End:
52,857,600 bp from pter
Size:
60,193 bases
Orientation:
Minus strand

Genomic View for ZNF28 Gene

Genes around ZNF28 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF28 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF28 Gene

Proteins for ZNF28 Gene

  • Protein details for ZNF28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17035-ZNF28_HUMAN
    Recommended name:
    Zinc finger protein 28
    Protein Accession:
    P17035
    Secondary Accessions:
    • A8KAK9
    • B4E3G0
    • B9EIK7
    • Q5H9V1
    • Q5HYM9
    • Q6ZML9
    • Q6ZN56

    Protein attributes for ZNF28 Gene

    Size:
    718 amino acids
    Molecular mass:
    83658 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAD18706.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF28 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF28 Gene

Proteomics data for ZNF28 Gene at MOPED

Post-translational modifications for ZNF28 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF28 Gene

No data available for DME Specific Peptides for ZNF28 Gene

Domains & Families for ZNF28 Gene

Gene Families for ZNF28 Gene

Protein Domains for ZNF28 Gene

Suggested Antigen Peptide Sequences for ZNF28 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P17035

UniProtKB/Swiss-Prot:

ZNF28_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 18 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 18 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF28: view

Function for ZNF28 Gene

Molecular function for ZNF28 Gene

GENATLAS Biochemistry:
zinc finger protein 28 (KOX24) (C2H2 type,Kruppel-like)
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF28: view

Animal Model Products

CRISPR Products

miRNA for ZNF28 Gene

miRTarBase miRNAs that target ZNF28

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF28 Gene

Localization for ZNF28 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF28 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF28 Gene COMPARTMENTS Subcellular localization image for ZNF28 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF28 Gene

Pathways & Interactions for ZNF28 Gene

SuperPathways for ZNF28 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF28: view

Pathways by source for ZNF28 Gene

2 Reactome pathways for ZNF28 Gene

Interacting Proteins for ZNF28 Gene

Gene Ontology (GO) - Biological Process for ZNF28 Gene

None

No data available for SIGNOR curated interactions for ZNF28 Gene

Drugs & Compounds for ZNF28 Gene

No Compound Related Data Available

Transcripts for ZNF28 Gene

Unigene Clusters for ZNF28 Gene

Zinc finger protein 28:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF28 Gene

No ASD Table

Relevant External Links for ZNF28 Gene

GeneLoc Exon Structure for
ZNF28
ECgene alternative splicing isoforms for
ZNF28

Expression for ZNF28 Gene

mRNA expression in normal human tissues for ZNF28 Gene

Protein differential expression in normal tissues from HIPED for ZNF28 Gene

This gene is overexpressed in Plasma (68.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF28 Gene



SOURCE GeneReport for Unigene cluster for ZNF28 Gene Hs.732407

genes like me logo Genes that share expression patterns with ZNF28: view

Protein tissue co-expression partners for ZNF28 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF28 Gene

Orthologs for ZNF28 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF28 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF28 35
  • 98.84 (n)
  • 98.19 (a)
ZNF28 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 41 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 53 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Aef1 37
  • 53 (a)
CG11247 37
  • 36 (a)
CG12299 37
  • 43 (a)
CG15436 37
  • 40 (a)
CG17612 37
  • 29 (a)
CG2129 37
  • 31 (a)
CG3941 37
  • 29 (a)
CG5245 37
  • 40 (a)
CG7386 37
  • 31 (a)
CG8319 37
  • 36 (a)
CG8388 37
  • 28 (a)
crol 37
  • 40 (a)
Kr-h1 37
  • 47 (a)
worm
(Caenorhabditis elegans)
Secernentea Y55F3AM.14 37
  • 37 (a)
Species with no ortholog for ZNF28:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ZNF28 Gene

ENSEMBL:
Gene Tree for ZNF28 (if available)
TreeFam:
Gene Tree for ZNF28 (if available)

Paralogs for ZNF28 Gene

(651) SIMAP similar genes for ZNF28 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for ZNF28 Gene

genes like me logo Genes that share paralogs with ZNF28: view

Variants for ZNF28 Gene

Sequence variations from dbSNP and Humsavar for ZNF28 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_036841 -
VAR_036842 -
VAR_036843 -

Structural Variations from Database of Genomic Variants (DGV) for ZNF28 Gene

Variant ID Type Subtype PubMed ID
esv2718786 CNV Deletion 23290073
esv2718787 CNV Deletion 23290073
dgv3980n71 CNV Gain 21882294
dgv3981n71 CNV Gain 21882294
nsv509752 CNV Insertion 20534489
esv2718796 CNV Deletion 23290073
dgv3984n71 CNV Gain 21882294
nsv833875 CNV Loss 17160897
esv2671531 CNV Deletion 23128226
esv2718798 CNV Deletion 23290073
nsv458746 CNV Gain 19166990
esv2445065 CNV Deletion 19546169
esv2718799 CNV Deletion 23290073
nsv817858 CNV Gain 17921354
nsv458747 CNV Gain 19166990
dgv3985n71 CNV Gain 21882294
nsv528436 CNV Loss 19592680
esv1065813 CNV Insertion 17803354
dgv1114e1 CNV Complex 17122850
dgv3986n71 CNV Loss 21882294
esv2464403 CNV Loss 19546169
dgv570e201 CNV Deletion 23290073
esv2673863 CNV Deletion 23128226
esv1009469 CNV Deletion 20482838
dgv660e199 CNV Deletion 23128226
nsv912327 CNV Loss 21882294
nsv9743 CNV Loss 18304495
esv1979870 CNV Deletion 18987734
esv999313 CNV Loss 20482838
esv28948 CNV Loss 19812545
esv2718801 CNV Deletion 23290073
esv2676843 CNV Deletion 23128226
esv1010802 CNV Loss 20482838
nsv828617 CNV Loss 20364138
nsv828618 CNV Loss 20364138
dgv3987n71 CNV Gain 21882294
nsv912331 CNV Gain+Loss 21882294
nsv912332 CNV Gain 21882294
dgv3988n71 CNV Gain+Loss 21882294
esv1004256 CNV Deletion 20482838
nsv828619 CNV Gain 20364138
esv21942 CNV Gain 19812545
esv2013773 CNV Deletion 18987734
nsv9744 CNV Gain 18304495

Variation tolerance for ZNF28 Gene

Residual Variation Intolerance Score: 95.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.68; 86.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF28 Gene

HapMap Linkage Disequilibrium report
ZNF28

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF28 Gene

Disorders for ZNF28 Gene

Relevant External Links for ZNF28

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF28

No disorders were found for ZNF28 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF28 Gene

Publications for ZNF28 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Chromosomal localization of 9 KOX zinc finger genes: physical linkages suggest clustering of KOX genes on chromosomes 12, 16, and 19. (PMID: 8262519) Rousseau-Merck M.F. … Berger R. (Hum. Genet. 1993) 3
  5. Multiple genes encoding zinc finger domains are expressed in human T cells. (PMID: 2288909) Thiesen H.-J. (New Biol. 1990) 3

Products for ZNF28 Gene

Sources for ZNF28 Gene

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