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Aliases for ZNF277 Gene

Aliases for ZNF277 Gene

  • Zinc Finger Protein 277 2 3
  • Nuclear Receptor-Interacting Factor 4 3 4
  • Zinc Finger Protein (C2H2 Type) 277 2 3
  • Zinc Finger Protein 277 Pseudogene 2 3
  • ZNF277P 3 4
  • NRIF4 3 4

External Ids for ZNF277 Gene

Previous HGNC Symbols for ZNF277 Gene

  • ZNF277P

Previous GeneCards Identifiers for ZNF277 Gene

  • GC07P110330
  • GC07P111393
  • GC07P111407
  • GC07P111440
  • GC07P111633
  • GC07P111846
  • GC07P106214

Summaries for ZNF277 Gene

GeneCards Summary for ZNF277 Gene

ZNF277 (Zinc Finger Protein 277) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity.

UniProtKB/Swiss-Prot for ZNF277 Gene

  • May be involved in transcriptional regulation

Gene Wiki entry for ZNF277 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF277 Gene

Genomics for ZNF277 Gene

Regulatory Elements for ZNF277 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF277 Gene

112,206,588 bp from pter
112,343,934 bp from pter
137,347 bases
Plus strand

Genomic View for ZNF277 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF277 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF277 Gene

Proteins for ZNF277 Gene

  • Protein details for ZNF277 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 277
    Protein Accession:
    Secondary Accessions:
    • Q75MZ2
    • Q75MZ3
    • Q8WY14

    Protein attributes for ZNF277 Gene

    450 amino acids
    Molecular mass:
    52788 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAF85941.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAS07413.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF277 Gene

Proteomics data for ZNF277 Gene at MOPED

Post-translational modifications for ZNF277 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF277 Gene

Antibody Products

No data available for DME Specific Peptides for ZNF277 Gene

Domains for ZNF277 Gene

Protein Domains for ZNF277 Gene


Graphical View of Domain Structure for InterPro Entry



  • Q9NRM2
  • Belongs to the ZNF277 family.
  • Contains 2 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF277: view

No data available for Gene Families for ZNF277 Gene

Function for ZNF277 Gene

Molecular function for ZNF277 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF277 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IEA --
GO:0005515 protein binding --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF277: view

Phenotypes for ZNF277 Gene

MGI mutant phenotypes for ZNF277:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with ZNF277: view

Animal Models for ZNF277 Gene

MGI Knock Outs for ZNF277:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF277

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF277 Gene

Localization for ZNF277 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF277 Gene

Subcellular locations from

Jensen Localization Image for ZNF277 Gene COMPARTMENTS Subcellular localization image for ZNF277 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ZNF277 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF277: view

Pathways for ZNF277 Gene

SuperPathways for ZNF277 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF277 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0070301 cellular response to hydrogen peroxide IEA --
GO:2000772 regulation of cellular senescence IEA --
genes like me logo Genes that share ontologies with ZNF277: view

No data available for Pathways by source for ZNF277 Gene

Transcripts for ZNF277 Gene

Unigene Clusters for ZNF277 Gene

Zinc finger protein 277:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF277

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF277 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: - -
SP2: -
SP3: -
SP4: - - -
SP5: - - - - -

Relevant External Links for ZNF277 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF277 Gene

mRNA expression in normal human tissues for ZNF277 Gene

Protein differential expression in normal tissues for ZNF277 Gene

This gene is overexpressed in Monocytes (42.5), Lung (14.4), and CD4 Tcells (12.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF277 Gene

SOURCE GeneReport for Unigene cluster for ZNF277 Gene Hs.655904

genes like me logo Genes that share expressions with ZNF277: view

Expression partners for ZNF277 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF277 Gene

Orthologs for ZNF277 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZNF277 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZNF277 35
  • 91.24 (n)
  • 89.53 (a)
ZNF277 36
  • 88 (a)
(Canis familiaris)
Mammalia ZNF277 35
  • 92.07 (n)
  • 91.11 (a)
ZNF277 36
  • 90 (a)
(Mus musculus)
Mammalia Zfp277 35
  • 84.37 (n)
  • 88.17 (a)
Zfp277 16
Zfp277 36
  • 67 (a)
(Pan troglodytes)
Mammalia ZNF277 35
  • 99.56 (n)
  • 99.33 (a)
ZNF277 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Zfp277 35
  • 85.04 (n)
  • 86.89 (a)
(Monodelphis domestica)
Mammalia ZNF277 36
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 67 (a)
-- 36
  • 80 (a)
(Gallus gallus)
Aves ZNF277 35
  • 75.31 (n)
  • 76.65 (a)
ZNF277 36
  • 74 (a)
(Anolis carolinensis)
Reptilia ZNF277 36
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.9892 35
znf277 35
  • 70.8 (n)
  • 72.32 (a)
(Danio rerio)
Actinopterygii zgc66407 35
znf277 35
  • 63.94 (n)
  • 63.32 (a)
znf277 36
  • 63 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9890 37
  • 36 (a)
CG9890 35
  • 47.52 (n)
  • 39.95 (a)
CG9890 36
  • 34 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011876 35
  • 47.04 (n)
  • 37.71 (a)
(Caenorhabditis elegans)
Secernentea F46B6.7 37
  • 37 (a)
ztf-7 35
  • 50.7 (n)
  • 42.37 (a)
ztf-7 36
  • 28 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7832 35
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC19B12.07c 35
  • 48.79 (n)
  • 33.82 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
-- 36
  • 39 (a)
Species with no ortholog for ZNF277:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZNF277 Gene

Gene Tree for ZNF277 (if available)
Gene Tree for ZNF277 (if available)

Paralogs for ZNF277 Gene

Selected SIMAP similar genes for ZNF277 Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with ZNF277: view

No data available for Paralogs for ZNF277 Gene

Variants for ZNF277 Gene

Sequence variations from dbSNP and Humsavar for ZNF277 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs714044 -- 112,212,267(+) TCTAT(A/G/T)TGGCT intron-variant
rs726422 -- 112,326,502(+) GGCTG(C/G)CCCTG intron-variant
rs726423 -- 112,326,642(+) TAGTT(A/T)AAAAA intron-variant
rs727807 -- 112,300,579(-) CACCA(A/G)CACTA intron-variant
rs960348 -- 112,212,627(+) TGCCT(A/G)CTCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF277 Gene

Variant ID Type Subtype PubMed ID
esv2422365 CNV Duplication 17116639
nsv464689 CNV Gain 19166990
esv268074 CNV Insertion 20981092
esv2656841 CNV Deletion 23128226
nsv5902 CNV Loss 18451855

Relevant External Links for ZNF277 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF277 Gene

Disorders for ZNF277 Gene

Relevant External Links for ZNF277

Genetic Association Database (GAD)

No disorders were found for ZNF277 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for ZNF277 Gene

Publications for ZNF277 Gene

  1. Chromosomal mapping and genomic organization of an evolutionarily conserved zinc finger gene ZNF277. (PMID: 10860669) Liang H. … Nagarajan L. (Genomics 2000) 2 3 4
  2. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  3. Finer delineation and transcript map of the 7q31 locus deleted in myeloid neoplasms. (PMID: 16213364) Liang H. … Nagarajan L. (Cancer Genet. Cytogenet. 2005) 2 3
  4. Human-specific nonsense mutations identified by genome sequence comparisons. (PMID: 16395595) Hahn Y. … Lee B. (Hum. Genet. 2006) 2 3
  5. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PMID: 16713569) Lim J. … Zoghbi H.Y. (Cell 2006) 3

Products for ZNF277 Gene

Sources for ZNF277 Gene

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