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Aliases for ZNF277 Gene

Aliases for ZNF277 Gene

  • Zinc Finger Protein 277 2 3 5
  • Nuclear Receptor-Interacting Factor 4 3 4
  • Zinc Finger Protein (C2H2 Type) 277 2 3
  • Zinc Finger Protein 277 Pseudogene 2 3
  • ZNF277P 3 4
  • NRIF4 3 4

External Ids for ZNF277 Gene

Previous HGNC Symbols for ZNF277 Gene

  • ZNF277P

Previous GeneCards Identifiers for ZNF277 Gene

  • GC07P110330
  • GC07P111393
  • GC07P111407
  • GC07P111440
  • GC07P111633
  • GC07P111846
  • GC07P106214

Summaries for ZNF277 Gene

GeneCards Summary for ZNF277 Gene

ZNF277 (Zinc Finger Protein 277) is a Protein Coding gene. Diseases associated with ZNF277 include specific language impairment and speech and communication disorders. GO annotations related to this gene include RNA polymerase II core promoter sequence-specific DNA binding.

UniProtKB/Swiss-Prot for ZNF277 Gene

  • May be involved in transcriptional regulation.

Gene Wiki entry for ZNF277 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF277 Gene

Genomics for ZNF277 Gene

Regulatory Elements for ZNF277 Gene

Promoters for ZNF277 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF277 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF277 Gene

Chromosome:
7
Start:
112,206,588 bp from pter
End:
112,343,934 bp from pter
Size:
137,347 bases
Orientation:
Plus strand

Genomic View for ZNF277 Gene

Genes around ZNF277 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF277 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF277 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF277 Gene

Proteins for ZNF277 Gene

  • Protein details for ZNF277 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRM2-ZN277_HUMAN
    Recommended name:
    Zinc finger protein 277
    Protein Accession:
    Q9NRM2
    Secondary Accessions:
    • Q75MZ2
    • Q75MZ3
    • Q8WY14

    Protein attributes for ZNF277 Gene

    Size:
    450 amino acids
    Molecular mass:
    52788 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF85941.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAS07413.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF277 Gene

Proteomics data for ZNF277 Gene at MOPED

Post-translational modifications for ZNF277 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF277 Gene

No data available for DME Specific Peptides for ZNF277 Gene

Domains & Families for ZNF277 Gene

Protein Domains for ZNF277 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9NRM2

UniProtKB/Swiss-Prot:

ZN277_HUMAN :
  • Belongs to the ZNF277 family.
  • Contains 2 C2H2-type zinc fingers.
Family:
  • Belongs to the ZNF277 family.
Similarity:
  • Contains 2 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF277: view

No data available for Gene Families for ZNF277 Gene

Function for ZNF277 Gene

Molecular function for ZNF277 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF277: view

Animal Models for ZNF277 Gene

MGI Knock Outs for ZNF277:

Animal Model Products

CRISPR Products

miRNA for ZNF277 Gene

miRTarBase miRNAs that target ZNF277

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF277 Gene

Localization for ZNF277 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF277 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF277 Gene COMPARTMENTS Subcellular localization image for ZNF277 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF277 Gene

Pathways & Interactions for ZNF277 Gene

SuperPathways for ZNF277 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF277 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070301 cellular response to hydrogen peroxide IEA --
genes like me logo Genes that share ontologies with ZNF277: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF277 Gene

Drugs & Compounds for ZNF277 Gene

No Compound Related Data Available

Transcripts for ZNF277 Gene

Unigene Clusters for ZNF277 Gene

Zinc finger protein 277:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF277 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: - -
SP2: -
SP3: -
SP4: - - -
SP5: - - - - -
SP6:

Relevant External Links for ZNF277 Gene

GeneLoc Exon Structure for
ZNF277
ECgene alternative splicing isoforms for
ZNF277

Expression for ZNF277 Gene

mRNA expression in normal human tissues for ZNF277 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF277 Gene

This gene is overexpressed in Monocytes (42.5), Lung (14.4), and CD4 Tcells (12.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF277 Gene



SOURCE GeneReport for Unigene cluster for ZNF277 Gene Hs.655904

genes like me logo Genes that share expression patterns with ZNF277: view

Protein tissue co-expression partners for ZNF277 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF277 Gene

Orthologs for ZNF277 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZNF277 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF277 36
  • 98 (a)
OneToOne
ZNF277 35
  • 99.56 (n)
  • 99.33 (a)
cow
(Bos Taurus)
Mammalia ZNF277 35
  • 91.24 (n)
  • 89.53 (a)
ZNF277 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF277 36
  • 90 (a)
OneToOne
ZNF277 35
  • 92.07 (n)
  • 91.11 (a)
mouse
(Mus musculus)
Mammalia Zfp277 16
Zfp277 36
  • 67 (a)
OneToOne
Zfp277 35
  • 84.37 (n)
  • 88.17 (a)
oppossum
(Monodelphis domestica)
Mammalia ZNF277 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 67 (a)
OneToMany
-- 36
  • 80 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Zfp277 35
  • 85.04 (n)
  • 86.89 (a)
chicken
(Gallus gallus)
Aves ZNF277 35
  • 75.31 (n)
  • 76.65 (a)
ZNF277 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF277 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.9892 35
znf277 35
  • 70.8 (n)
  • 72.32 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc66407 35
znf277 35
  • 63.94 (n)
  • 63.32 (a)
znf277 36
  • 63 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011876 35
  • 47.04 (n)
  • 37.71 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9890 35
  • 47.52 (n)
  • 39.95 (a)
CG9890 37
  • 36 (a)
CG9890 36
  • 34 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F46B6.7 37
  • 37 (a)
ztf-7 36
  • 28 (a)
OneToOne
ztf-7 35
  • 50.7 (n)
  • 42.37 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC19B12.07c 35
  • 48.79 (n)
  • 33.82 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7832 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
OneToMany
-- 36
  • 39 (a)
OneToMany
Species with no ortholog for ZNF277:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZNF277 Gene

ENSEMBL:
Gene Tree for ZNF277 (if available)
TreeFam:
Gene Tree for ZNF277 (if available)

Paralogs for ZNF277 Gene

genes like me logo Genes that share paralogs with ZNF277: view

No data available for Paralogs for ZNF277 Gene

Variants for ZNF277 Gene

Sequence variations from dbSNP and Humsavar for ZNF277 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
VAR_035574 A breast cancer sample
VAR_035575 A breast cancer sample
rs11539696 - 112,340,952(+) GCCAT(A/G)TGAAG reference, missense
rs34571830 - 112,318,236(+) ATGGC(A/G)TTTGT reference, missense
rs1016274 -- 112,335,234(+) TGGGC(C/T)TGATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF277 Gene

Variant ID Type Subtype PubMed ID
esv2422365 CNV Duplication 17116639
nsv464689 CNV Gain 19166990
esv268074 CNV Insertion 20981092
esv2656841 CNV Deletion 23128226
nsv5902 CNV Loss 18451855

Variation tolerance for ZNF277 Gene

Residual Variation Intolerance Score: 29.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.08; 60.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF277 Gene

HapMap Linkage Disequilibrium report
ZNF277
Human Gene Mutation Database (HGMD)
ZNF277

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF277 Gene

Disorders for ZNF277 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZNF277 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
specific language impairment
speech and communication disorders
  • communication disorder
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZNF277

Genetic Association Database (GAD)
ZNF277
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF277
genes like me logo Genes that share disorders with ZNF277: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF277 Gene

Publications for ZNF277 Gene

  1. Chromosomal mapping and genomic organization of an evolutionarily conserved zinc finger gene ZNF277. (PMID: 10860669) Liang H. … Nagarajan L. (Genomics 2000) 2 3 4 67
  2. Human-specific nonsense mutations identified by genome sequence comparisons. (PMID: 16395595) Hahn Y. … Lee B. (Hum. Genet. 2006) 2 3
  3. Finer delineation and transcript map of the 7q31 locus deleted in myeloid neoplasms. (PMID: 16213364) Liang H. … Nagarajan L. (Cancer Genet. Cytogenet. 2005) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for ZNF277 Gene

Sources for ZNF277 Gene

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