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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF277 Gene

protein-coding   GIFtS: 50
GCID: GC07P111846

Zinc Finger Protein 277

(Previous names: zinc finger protein (C2H2 type) 277, zinc finger protein...)
(Previous symbol: ZNF277P)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 2771 2
ZNF277P1 2 3
Zinc Finger Protein (C2H2 Type) 2771 2
Zinc Finger Protein 277 Pseudogene1 2
Nuclear Receptor-Interacting Factor 42 3
NRIF42 3

External Ids:    HGNC: 130701   Entrez Gene: 111792   Ensembl: ENSG000001988397   OMIM: 6054655   UniProtKB: Q9NRM23   

Export aliases for ZNF277 gene to outside databases

Previous GC identifers: GC07P110330 GC07P111393 GC07P111407 GC07P111440 GC07P111633 GC07P106214


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF277 Gene: 
ZNF277 (zinc finger protein 277) is a protein-coding gene. Diseases associated with ZNF277 include breast cancer. GO annotations related to this gene include DNA binding and sequence-specific DNA binding transcription factor activity.

UniProtKB/Swiss-Prot: ZN277_HUMAN, Q9NRM2
Function: May be involved in transcriptional regulation

Gene Wiki entry for ZNF277 (ZNF277P) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007933.15  NC_018918.2  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF277 gene promoter:
         STAT5B   Olf-1   IRF-1   Evi-1   Egr-4   CREB   AREB6   Chx10   TGIF   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ZNF277 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF277

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF277


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q31.1   Ensembl cytogenetic band:  7q31.1   HGNC cytogenetic band: 7q31.1

ZNF277 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF277 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P111846:  view genomic region     (about GC identifiers)

Start:
111,846,643 bp from pter      End:
111,983,989 bp from pter
Size:
137,347 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 111,215,182-111,352,524     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN277_HUMAN, Q9NRM2 (See protein sequence)
Recommended Name: Zinc finger protein 277  
Size: 450 amino acids; 52788 Da
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=AAF85941.1; Type=Erroneous initiation; Sequence=AAS07413.1; Type=Erroneous initiation;
Secondary accessions: Q75MZ2 Q75MZ3 Q8WY14

Explore the universe of human proteins at neXtProt for ZNF277: NX_Q9NRM2

Explore proteomics data for ZNF277 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NRM2

  • ZNF277 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF277 Protein Expression
    REFSEQ proteins: NP_068834.2  
    ENSEMBL proteins: 
     ENSP00000354501   ENSP00000355043   ENSP00000410538   ENSP00000402846   ENSP00000390359  
     ENSP00000402292   ENSP00000415735  

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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZNF277 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS--

    ZNF277 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. ELISAs for ZNF277 
    Cloud-Clone Corp. CLIAs for ZNF277


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9NRM2

    ProtoNet protein and cluster: Q9NRM2

    UniProtKB/Swiss-Prot: ZN277_HUMAN, Q9NRM2
    Similarity: Belongs to the ZNF277 family
    Similarity: Contains 2 C2H2-type zinc fingers


    ZNF277 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN277_HUMAN, Q9NRM2
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity NAS--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF277 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Zfp277):
     cellular 

    ZNF277 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Zfp277tm1Aiwa for ZNF277

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZNF277 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ZNF277

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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZNF277 

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    hsa-miR-498 hsa-miR-607 hsa-miR-197 hsa-miR-3182 hsa-miR-103a-2*
    SwitchGear 3'UTR luciferase reporter plasmidZNF277 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF277

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/14 Interacting proteins for ZNF277 (Q9NRM23 ENSP000003545014) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACOT2P497533, ENSP000002386514I2D: score=2 STRING: ENSP00000238651
    COILP384323, ENSP000002403164I2D: score=2 STRING: ENSP00000240316
    ZNF768Q9H5H43, ENSP000003697774I2D: score=1 STRING: ENSP00000369777
    GPRC5CQ9NQ843, ENSP000003405954I2D: score=1 STRING: ENSP00000340595
    DDB1Q165313, ENSP000003017644I2D: score=1 STRING: ENSP00000301764
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent NAS--

    ZNF277 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF277 (ZN277)

    Search CenterWatch for drugs/clinical trials and news about ZNF277 / ZN277

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF277 gene: 
    NM_021994.2  

    Unigene Cluster for ZNF277:

    Zinc finger protein 277
    Hs.655904  [show with all ESTs]
    Unigene Representative Sequence: NM_021994
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361822(uc003vge.2 uc003vgf.2) ENST00000361946 ENST00000421043(uc003vgc.3)
    ENST00000457808 ENST00000425229 ENST00000450657(uc003vgd.3) ENST00000421864

    miRNA
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNF277:
    hsa-miR-498 hsa-miR-607 hsa-miR-197 hsa-miR-3182 hsa-miR-103a-2*
    SwitchGear 3'UTR luciferase reporter plasmidZNF277 3' UTR sequence
    Inhib. RNA
    Products:
         
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF277

    Additional mRNA sequence: 

    AF209198.1 AF308819.1 AK027128.1 AK314630.1 AL713791.1 BC020626.1 

    8 DOTS entries:

    DT.100776590  DT.112863  DT.91677011  DT.95269735  DT.87011048  DT.121115903  DT.99992738  DT.121115930 

    24/142 AceView cDNA sequences (see all 142):

    AF308819 T81532 CR606452 CB114668 BX460665 AI241170 CA396831 BM822099 
    AF209198 CR604080 BX091635 AA486202 N24381 BM788257 AI638572 AI671325 
    BF727443 BE645373 CR600080 AI635559 BC020626 CR605159 NM_021994 AL522105 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF277 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
    SP1:                          -                                         -                                 
    SP2:                          -                                                                           
    SP3:                          -                                                                           
    SP4:                          -     -                                   -                                 
    SP5:                          -     -     -     -                       -                                 


    ECgene alternative splicing isoforms for ZNF277

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF277 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGCAGTCTG
    ZNF277 Expression
    About this image


    See ZNF277 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF277

    SOURCE GeneReport for Unigene cluster: Hs.655904
        SABiosciences Custom PCR Arrays for ZNF277
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ZNF277 gene from 7/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp2771 , 5 zinc finger protein 2771, 5 84.37(n)1
    88.17(a)1
      12 (18.06 cM)5
    2461961  NM_178845.31  NP_849173.21 
     403150465 
    chicken
    (Gallus gallus)
    Aves ZNF2771 zinc finger protein 277 76.14(n)
    77.83(a)
      427859  NM_001195469.1  NP_001182398.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZNF2776
    zinc finger protein 277
    66(a)
    1 ↔ 1
    5(58378253-58427189)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480610842   -- 75.67(n)    48061084 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc664072 hypothetical protein MGC66407 73.84(n)   393402  BC054699.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG98901 , 3 CG98901 36(a)3
    48.11(n)1
    40.81(a)1
      59C33
    376591  NM_137906.31  NP_611750.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F46B6.73
    ztf-71
    Zinc finger, C2H2 type3
    Protein ZTF-71
    37(a)3
    50.17(n)1
    41.62(a)1
      V(9790103-9792232)3
    1793751  NM_073125.31  NP_505526.11 


    ENSEMBL Gene Tree for ZNF277 (if available)
    TreeFam Gene Tree for ZNF277 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF277 gene
    1 SIMAP similar gene for ZNF277 using alignment to 10 protein entries:     ZN277_HUMAN (see all proteins):
    DKFZp566A0447

    ZNF277 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2339 SNPs in ZNF277 are shown (see all 2339)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0355754
    A breast cancer sample4--see VAR_0355752 L F mis40--------
    VAR_0355744
    A breast cancer sample4--see VAR_0355742 I L mis40--------
    rs1840093331,2
    --111848511(+) GTTTAA/GAAGTT 1 -- int10--------
    rs78106361,2
    C--111848585(+) CACAGT/CACCAC 1 -- int19Minor allele frequency- C:0.22NA WA CSA EA 369
    rs1997281371,2
    C--111848640(+) ACATA-/TTCTTCTT 1 -- int10--------
    rs1125290221,2
    C--111848651(+) TTCTTC/TTTTTT 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs1892329881,2
    --111848654(+) TTCTTC/TTTTTT 1 -- int10--------
    rs1117673371,2
    F--111848678(+) AATCCA/C/GTATTC 1 -- int11CSA 1
    rs20407261,2
    C,F,A,H--111848705(+) TCTTAT/CATGAC 1 -- int110Minor allele frequency- C:0.09NS EA NA WA 796
    rs1443499771,2
    C--111848905(+) TAGTTA/TTTTGT 1 -- int10--------

    HapMap Linkage Disequilibrium report for ZNF277 (111846643 - 111983989 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for ZNF277:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2656841CNV Deletion23128226
    esv2422365CNV Duplication17116639
    esv268074CNV Insertion20981092
    nsv5902CNV Loss18451855
    nsv464689CNV Gain19166990

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605465    OMIM disorders: --

    2 diseases for ZNF277:    About MalaCards
    breast cancer    


    ZNF277 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZNF277

    Export disorders for ZNF277 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF277 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with ZNF277)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Chromosomal mapping and genomic organization of an evolutionarily conserved zinc finger gene ZNF277. (PubMed id 10860669)1, 2, 3 Liang H.... Nagarajan L. (2000)
    2. Human-specific nonsense mutations identified by genome sequence comparisons. (PubMed id 16395595)1, 3 Hahn Y. and Lee B. (2006)
    3. Finer delineation and transcript map of the 7q31 locus deleted in myeloid neoplasms. (PubMed id 16213364)1, 3 Liang H....Nagarajan L. (2005)
    4. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    5. Genetic variants associated with breast size also infl uence breast cancer risk. (PubMed id 22747683)1 Eriksson N....Tung J.Y. (2012)
    6. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    7. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
    8. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PubMed id 17903300)4 Fox C.S....Atwood L.D. (2007)
    9. Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness. (PubMed id 17903302)4 Levy D....Mitchell G.F. (2007)
    10. Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study. (PubMed id 17903295)4 Lunetta K.L....Murabito J.M. (2007)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11179 HGNC: 13070 AceView: ZNF277 Ensembl:ENSG00000198839 euGenes: HUgn11179
    ECgene: ZNF277 H-InvDB: ZNF277

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF277 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF277 gene:
    Search GeneIP for patents involving ZNF277

    GeneCards and IP:
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