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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF276 Gene

protein-coding   GIFtS: 47
GCID: GC16P089788

Zinc Finger Protein 276

(Previous name: zinc finger protein 276 homolog (mouse))
(Previous symbol: ZFP276)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 2761 2     CENP-Z2
ZFP2761 2 3 5     CENPZ2
Centromere Protein Z1 2     zfp-2762
Zinc Finger Protein 4772 3     Zinc Finger Protein 276 Homolog2
ZNF4772 3     Zfp-2763
Zinc Finger Protein 276 Homolog (Mouse)1     

External Ids:    HGNC: 233301   Entrez Gene: 928222   Ensembl: ENSG000001588057   OMIM: 6084605   UniProtKB: Q8N5543   

Export aliases for ZNF276 gene to outside databases

Previous GC identifers: GC16P088315 GC16P075482


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF276 Gene: 
ZNF276 (zinc finger protein 276) is a protein-coding gene. Diseases associated with ZNF276 include fanconi's anemia, and anemia. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF692.

UniProtKB/Swiss-Prot: ZN276_HUMAN, Q8N554
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010542.15  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF276 gene promoter:
         AML1a   CP2   NF-kappaB2   NF-kappaB1   NF-kappaB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF276 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF276

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF276


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q24.3   Ensembl cytogenetic band:  16q24.3   HGNC cytogenetic band: 16q24.3

ZNF276 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF276 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P089788:  view genomic region     (about GC identifiers)

Start:
89,786,808 bp from pter      End:
89,807,333 bp from pter
Size:
20,526 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN276_HUMAN, Q8N554 (See protein sequence)
Recommended Name: Zinc finger protein 276  
Size: 614 amino acids; 67219 Da
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=AAH32781.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=AAI10349.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q0VGA1 Q2TBE8 Q3B7H7
Alternative splicing: 2 isoforms:  Q8N554-1   Q8N554-2   

Explore the universe of human proteins at neXtProt for ZNF276: NX_Q8N554

Explore proteomics data for ZNF276 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N554

  • ZNF276 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF276 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001106997.1  NP_689500.2  

    ENSEMBL proteins: 
     ENSP00000455466   ENSP00000289816   ENSP00000457210   ENSP00000415836   ENSP00000457313  
     ENSP00000455345   ENSP00000415999  

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    Cloud-Clone Corp. Proteins for ZNF276 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    ZNF276 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2
     IPR012934 Znf_AD

    Graphical View of Domain Structure for InterPro Entry Q8N554

    ProtoNet protein and cluster: Q8N554

    2 Blocks protein domains:
    IPB011069 Aspartate carbamoyltransferase
    IPB012934 Zinc finger


    UniProtKB/Swiss-Prot: ZN276_HUMAN, Q8N554
    Similarity: Contains 5 C2H2-type zinc fingers
    Similarity: Contains 1 ZAD (zinc-finger associated) domain


    ZNF276 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN276_HUMAN, Q8N554
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding IEA--
    GO:0046872metal ion binding ----
         
    ZNF276 for ontologies           About GeneDecksing


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    SwitchGear 3'UTR luciferase reporter plasmidZNF276 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF276

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5 Interacting proteins for ZNF276 (Q8N5542, 3 ENSP000004158364) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATXN1P542532, 3, ENSP000002447694MINT-2877949 I2D: score=3 STRING: ENSP00000244769
    ZBTB8AQ96BR92, 3, ENSP000003626094MINT-67908 I2D: score=3 STRING: ENSP00000362609
    NFKB1P198383, ENSP000002265744I2D: score=1 STRING: ENSP00000226574
    GCC1Q96CN93I2D: score=1 
    MSH3P205853I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF276 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF276 (ZN276)

    Search CenterWatch for drugs/clinical trials and news about ZNF276 / ZN276

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF276 gene (2 alternative transcripts): 
    NM_001113525.1  NM_152287.3  

    Unigene Cluster for ZNF276:

    Zinc finger protein 276
    Hs.290154  [show with all ESTs]
    Unigene Representative Sequence: NM_001113525
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000562530 ENST00000289816(uc010ciq.3 uc002foq.4 uc010cir.3 uc002for.4 uc010cis.3 uc002fos.4 uc002fot.4 uc010vpm.2)
    ENST00000568064 ENST00000563983(uc010cit.2) ENST00000443381 ENST00000568295
    ENST00000561536 ENST00000563541 ENST00000569426 ENST00000564004 ENST00000569582
    ENST00000569901 ENST00000446326
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    Inhib. RNA
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    Additional mRNA sequence: 

    AK096004.1 AK289801.1 AK295770.1 AK315793.1 BC032781.1 BC038839.1 BC105959.1 BC107603.1 
    BC110348.1 

    20 DOTS entries:

    DT.98131728  DT.95071370  DT.95345597  DT.120714578  DT.120714449  DT.95132431  DT.40247153  DT.92436711 
    DT.100029399  DT.95356823  DT.120714406  DT.120714557  DT.446662  DT.91663653  DT.91796157  DT.120714496 
    DT.207278  DT.100752051  DT.86856648  DT.99975779 

    24/105 AceView cDNA sequences (see all 105):

    BG236318 Z40208 BU735910 BI554136 AW074388 BM681111 BM727684 BU786178 
    BM988644 CR620615 BU956483 BI819458 CD515874 AI926131 BQ432535 NM_152287 
    CA773810 CA430616 BF059472 BI753531 AA455885 AI341412 AK056405 AI475819 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF276 (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16
    SP1:                                                                                                              -                           
    SP2:        -     -     -                 -                                                                                                   
    SP3:                    -                 -                                                                                                   
    SP4:                                                                                            -                                             
    SP5:                                                                                                                                          


    ECgene alternative splicing isoforms for ZNF276

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF276 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTATGCTTGT
    ZNF276 Expression
    About this image


    See ZNF276 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF276

    SOURCE GeneReport for Unigene cluster: Hs.290154
        SABiosciences Custom PCR Arrays for ZNF276
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ZNF276 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp2761 , 5 zinc finger protein (C2H2 type) 2761, 5 81.75(n)1
    80.88(a)1
      8 (72.09 cM)5
    572471  NM_020497.21  NP_065243.21 
     1232541955 
    chicken
    (Gallus gallus)
    Aves ZNF2761 zinc finger protein 276 71.82(n)
    70.17(a)
      415853  XM_414213.3  XP_414213.2 
    lizard
    (Anolis carolinensis)
    Reptilia ZNF2766
    zinc finger protein 276
    55(a)
    1 ↔ 1
    GL344093.1(45034-63286)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.199562 Transcribed sequence with weak similarity to protein more 86.91(n)    CF103168.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG153366
    CG182626
    (see all 4)
    --
    16(a)
    15(a)
    (see all 4)
    possible ortholog
    1 ↔ many
    (see all 4)
    X(8041982-8042529)
    X(8046981-8048566)


    ENSEMBL Gene Tree for ZNF276 (if available)
    TreeFam Gene Tree for ZNF276 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF276 gene
    ZNF6922  ZNF6532  ZFP912  ENSG000002674772  ZFP91-CNTF2  
    15 SIMAP similar genes for ZNF276 using alignment to 7 protein entries:     ZN276_HUMAN (see all proteins):
    kr-znf3    ZNF692    A-328A3.4    ZFS-2    HZF40    ZFS-6
    ZNF55    ZNF72    HZF16    ZNF844    DKFZp434J0650    ZNF
    ZNF808    ZNFN1A2    smap-7

    ZNF276 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/562 SNPs in ZNF276 are shown (see all 562)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0191254
    ----see VAR_0191252 R W mis40--------
    VAR_0191264
    ----see VAR_0191262 E D mis40--------
    rs1412452621,2
    C--89789491(+) ACGAGC/TGCTGT 2 -- int11Minor allele frequency- T:0.00EU 535
    rs285577821,2
    C,F--89789506(+) CTCCGC/ACTGCT 2 -- int12Minor allele frequency- A:0.03NA EU 690
    rs2014348431,2
    C--89789530(+) GCCACA/GCTGAT 2 -- int11Minor allele frequency- G:0.00EU 1305
    rs1414802991,2
    C,F--89789565(+) CCCAAC/GAGGGG 4 T R mis11Minor allele frequency- G:0.00NA 4536
    rs1114812991,2
    C,F--89789569(+) ACAGGG/AGCAGA 4 /G syn12Minor allele frequency- A:0.01CSA NA 4536
    rs1924545761,2
    C--89789633(+) GACCAC/G/TCCGTG 2 -- int10--------
    rs1388768691,2
    C--89789634(+) ACCAGC/TCGTGG 2 -- int10--------
    rs617445221,2
    C,F--89789675(+) GATCTG/TATCAC 4 L syn12Minor allele frequency- T:0.00NS NA 4610

    HapMap Linkage Disequilibrium report for ZNF276 (89786808 - 89807333 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/23 variations for ZNF276 (see all 23):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2715199CNV Deletion23290073
    esv2672413CNV Deletion23128226
    dgv424e201CNV Deletion23290073
    dgv517e199CNV Deletion23128226
    esv1995159CNV Deletion18987734
    esv1401930CNV Insertion17803354
    nsv1931CNV Insertion18451855
    nsv509639CNV Insertion20534489
    nsv907425CNV Loss21882294
    dgv3009n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608460    OMIM disorders: --

    3 diseases for ZNF276:    About MalaCards
    fanconi's anemia    anemia    breast cancer


    ZNF276 for disorders           About GeneDecksing


    Export disorders for ZNF276 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF276 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF276)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Cloning and mutation analysis of ZFP276 as a candidate tumor suppressor in breast cancer. (PubMed id 14605947)1, 2 Wong J.C.... Buchwald M. (2003)
    4. Cloning and analysis of the mouse Fanconi anemia group A cDNA and an overlapping penta zinc finger cDNA. (PubMed id 10936049)1, 3 Wong J.C....Buchwald M. (2000)
    5. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    7. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (2006)
    8. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
    9. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 92822 HGNC: 23330 AceView: ZFP276 Ensembl:ENSG00000158805 euGenes: HUgn92822
    ECgene: ZNF276 H-InvDB: ZNF276

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF276 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF276 gene:
    Search GeneIP for patents involving ZNF276

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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