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Aliases for ZNF276 Gene

Aliases for ZNF276 Gene

  • Zinc Finger Protein 276 2 3 5
  • Zinc Finger Protein 477 3 4
  • Centromere Protein Z 2 3
  • Zinc Finger, AD-Type 2 3
  • Zfp-276 3 4
  • ZFP276 3 4
  • CENP-Z 3 4
  • ZNF477 3 4
  • Zinc Finger Protein 276 Homolog (Mouse) 2
  • Zinc Finger Protein 276 Homolog 3
  • CENPZ 3
  • ZADT 3

External Ids for ZNF276 Gene

Previous HGNC Symbols for ZNF276 Gene

  • ZFP276

Previous GeneCards Identifiers for ZNF276 Gene

  • GC16P088315
  • GC16P089788
  • GC16P075482

Summaries for ZNF276 Gene

GeneCards Summary for ZNF276 Gene

ZNF276 (Zinc Finger Protein 276) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF653.

UniProtKB/Swiss-Prot for ZNF276 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF276 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF276 Gene

Genomics for ZNF276 Gene

Regulatory Elements for ZNF276 Gene

Enhancers for ZNF276 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H089832 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.8 +115.6 115604 6.6 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 BRCA1 YY1 ZNF121 SLC30A9 CDK10 SPIRE2 TUBB3 VPS9D1 ZNF276 FANCA RPL13 ACSF3 MC1R LOC105371419
GH16H089480 2.1 FANTOM5 Ensembl ENCODE dbSUPER 10.1 -233.4 -233442 12 HDGF PKNOX1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B SPG7 ZNF778 ZC3H18 AFG3L1P MC1R ANKRD11 ENSG00000259877 RPL13 TCF25 RNU6-430P
GH16H089003 1.6 FANTOM5 ENCODE dbSUPER 10.9 -715.9 -715936 1.1 HDGF PKNOX1 ATF1 ARNT YY1 TCF12 ZNF766 CBX5 GATA2 ELK1 ACSF3 ZNF276 TCF25 CBFA2T3 PIR32035 ENSG00000256982
GH16H089842 1.4 Ensembl ENCODE dbSUPER 11.8 +122.9 122908 1.5 NFIB SIN3A RFX5 ZNF121 GLIS2 GATA2 EGR1 ZNF366 FOS RCOR1 SPATA2L SPIRE2 CDK10 FANCA ZNF276 VPS9D1 LOC105371419
GH16H089313 2.2 VISTA FANTOM5 Ensembl ENCODE dbSUPER 7.2 -399.6 -399592 14.6 PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A FEZF1 YY1 ZNF766 ZNF143 CDK10 DBNDD1 ZNF276 ANKRD11 LOC100287036 SPG7 SNAI3 GAS8-AS1 TUBB3 RPL13
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF276 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF276 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000089773 1405 2401 PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF143

Genomic Locations for ZNF276 Gene

Genomic Locations for ZNF276 Gene
20,731 bases
Plus strand

Genomic View for ZNF276 Gene

Genes around ZNF276 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF276 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF276 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF276 Gene

Proteins for ZNF276 Gene

  • Protein details for ZNF276 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 276
    Protein Accession:
    Secondary Accessions:
    • Q0VGA1
    • Q2TBE8
    • Q3B7H7

    Protein attributes for ZNF276 Gene

    614 amino acids
    Molecular mass:
    67219 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH32781.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAI10349.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF276 Gene


neXtProt entry for ZNF276 Gene

Post-translational modifications for ZNF276 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF276 Gene

Domains & Families for ZNF276 Gene

Gene Families for ZNF276 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for ZNF276 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZNF276: view

No data available for UniProtKB/Swiss-Prot for ZNF276 Gene

Function for ZNF276 Gene

Molecular function for ZNF276 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF276 Gene

Gene Ontology (GO) - Molecular Function for ZNF276 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 16189514
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF276: view

Phenotypes for ZNF276 Gene

GenomeRNAi human phenotypes for ZNF276:
genes like me logo Genes that share phenotypes with ZNF276: view

Animal Model Products

CRISPR Products

miRNA for ZNF276 Gene

miRTarBase miRNAs that target ZNF276

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF276 Gene

Localization for ZNF276 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF276 Gene

Nucleus. Chromosome, centromere, kinetochore.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF276 gene
Compartment Confidence
nucleus 5
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
  • Nucleus (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF276 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IDA,IEA 20813266
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005634 nucleus IEA --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with ZNF276: view

Pathways & Interactions for ZNF276 Gene

SuperPathways for ZNF276 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF276 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF276: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF276 Gene

Drugs & Compounds for ZNF276 Gene

No Compound Related Data Available

Transcripts for ZNF276 Gene

Unigene Clusters for ZNF276 Gene

Zinc finger protein 276:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF276 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16
SP1: -
SP2: - - - -
SP3: - -
SP4: -
SP6: - -
SP8: -

Relevant External Links for ZNF276 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF276 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF276 Gene

Protein differential expression in normal tissues from HIPED for ZNF276 Gene

This gene is overexpressed in Colon muscle (22.5), Peripheral blood mononuclear cells (16.0), Pancreatic juice (10.6), and Bone (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF276 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF276 Gene:


SOURCE GeneReport for Unigene cluster for ZNF276 Gene:


Evidence on tissue expression from TISSUES for ZNF276 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with ZNF276: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF276 Gene

Orthologs for ZNF276 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF276 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF276 33 34
  • 99.46 (n)
(Canis familiaris)
Mammalia ZNF276 33 34
  • 85.66 (n)
(Bos Taurus)
Mammalia ZNF276 33 34
  • 82.61 (n)
(Rattus norvegicus)
Mammalia Zfp276 33
  • 82.56 (n)
(Mus musculus)
Mammalia Zfp276 33 16 34
  • 81.75 (n)
(Monodelphis domestica)
Mammalia ZNF276 34
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia ZNF276 34
  • 73 (a)
(Gallus gallus)
Aves ZNF276 33 34
  • 70.15 (n)
(Anolis carolinensis)
Reptilia ZNF276 34
  • 55 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia znf276 33
  • 59.65 (n)
(Danio rerio)
Actinopterygii im:7141269 34
  • 19 (a)
zgc:171673 34
  • 19 (a)
Dr.19956 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 15 (a)
Species where no ortholog for ZNF276 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF276 Gene

Gene Tree for ZNF276 (if available)
Gene Tree for ZNF276 (if available)

Paralogs for ZNF276 Gene

Paralogs for ZNF276 Gene

genes like me logo Genes that share paralogs with ZNF276: view

Variants for ZNF276 Gene

Sequence variations from dbSNP and Humsavar for ZNF276 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs397507553 Pathogenic 89,740,842(-) CTTCT(-/TCT)CCTTG nc-transcript-variant, cds-indel
rs747892390 Pathogenic 89,739,218(+) TCAAG(-/TACATGTCCACAGC)AACAT nc-transcript-variant, reference, utr-variant-3-prime, frameshift-variant
rs761988162 Pathogenic 89,739,290(+) GAAGA(C/T)TAGAG nc-transcript-variant, utr-variant-3-prime, splice-acceptor-variant
rs762902309 Likely pathogenic 89,739,285(+) GGAGA(-/G)AAGAC nc-transcript-variant, reference, utr-variant-3-prime, frameshift-variant
rs11649210 Likely benign 89,740,825(+) GACGA(A/C/G/T)AGCAG nc-transcript-variant, reference, synonymous-codon, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF276 Gene

Variant ID Type Subtype PubMed ID
nsv958046 CNV deletion 24416366
nsv952079 CNV deletion 24416366
nsv833331 CNV gain+loss 17160897
nsv833330 CNV loss 17160897
nsv573744 CNV loss 21841781
nsv573743 CNV gain 21841781
nsv516241 CNV loss 19592680
nsv509639 CNV insertion 20534489
nsv482951 CNV loss 15286789
nsv457624 CNV loss 19166990
nsv457623 CNV gain 19166990
nsv428331 CNV gain+loss 18775914
nsv1931 CNV insertion 18451855
nsv1152934 CNV deletion 26484159
esv3572253 CNV gain 25503493
esv2762221 CNV gain+loss 21179565
esv2715199 CNV deletion 23290073
esv2672413 CNV deletion 23128226
esv25585 CNV loss 19812545
esv1995159 CNV deletion 18987734
esv1401930 CNV insertion 17803354
dgv875e212 CNV loss 25503493
dgv874e212 CNV loss 25503493
dgv873e212 CNV loss 25503493
dgv872e212 CNV loss 25503493
dgv517e199 CNV deletion 23128226
dgv387e201 CNV deletion 23290073

Variation tolerance for ZNF276 Gene

Residual Variation Intolerance Score: 68.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.20; 52.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF276 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF276 Gene

Disorders for ZNF276 Gene

Relevant External Links for ZNF276

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF276 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF276 Gene

Publications for ZNF276 Gene

  1. The protein composition of mitotic chromosomes determined using multiclassifier combinatorial proteomics. (PMID: 20813266) Ohta S … Rappsilber J (Cell 2010) 2 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Cloning and mutation analysis of ZFP276 as a candidate tumor suppressor in breast cancer. (PMID: 14605947) Wong JC … Buchwald M (Journal of human genetics 2003) 3 4 60
  5. Cloning and analysis of the mouse Fanconi anemia group A cDNA and an overlapping penta zinc finger cDNA. (PMID: 10936049) Wong JC … Buchwald M (Genomics 2000) 2 3 60

Products for ZNF276 Gene

Sources for ZNF276 Gene

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