Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF274 Gene

Aliases for ZNF274 Gene

  • Zinc Finger Protein 274 2 3 4 5
  • Zinc Finger Protein With KRAB And SCAN Domains 19 3 4
  • Zinc Finger Protein HFB101 3 4
  • Zinc Finger Protein Zfp2 3 4
  • ZKSCAN19 3 4
  • ZF2 3 4
  • Neurotrophin Receptor-Interacting Factor Homolog 3
  • KRAB Zinc Finger Protein HFB101 3
  • ZSCAN51 3
  • HFB101 3

External Ids for ZNF274 Gene

Previous GeneCards Identifiers for ZNF274 Gene

  • GC19P059592
  • GC19P059148
  • GC19P063370
  • GC19P063386
  • GC19P058695
  • GC19P055004

Summaries for ZNF274 Gene

Entrez Gene Summary for ZNF274 Gene

  • This gene encodes a zinc finger protein containing five C2H2-type zinc finger domains, one or two Kruppel-associated box A (KRAB A) domains, and a leucine-rich domain. The encoded protein has been suggested to be a transcriptional repressor. It localizes predominantly to the nucleolus. Alternatively spliced transcript variants encoding different isoforms exist. These variants utilize alternative polyadenylation signals. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZNF274 Gene

ZNF274 (Zinc Finger Protein 274) is a Protein Coding gene. Diseases associated with ZNF274 include Frasier Syndrome. Among its related pathways are Gene Expression and Development HGF signaling pathway. GO annotations related to this gene include nucleic acid binding and sequence-specific DNA binding. An important paralog of this gene is ZNF483.

UniProtKB/Swiss-Prot for ZNF274 Gene

  • Probable transcription repressor. Specifically binds to the 3-end of zinc-finger coding genes and recruiting chromatin-modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression. The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610).

Gene Wiki entry for ZNF274 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF274 Gene

Genomics for ZNF274 Gene

Regulatory Elements for ZNF274 Gene

Enhancers for ZNF274 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G058181 1.1 ENCODE 0.7 +0.2 248 2.5 HDGF PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ZNF134 ZNF549 ZNF606 ZNF773 ZNF17 ZNF418 ZNF550 ZNF417 ZNF256 ZNF543
GH19G058203 0.8 FANTOM5 ENCODE 0.3 +21.4 21378 1.0 AGO1 ZBTB33 ZNF311 RBFOX2 LOC105372483 ZNF837 ZNF544 C19orf18 GC19P058214 ZNF274
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF274 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF274 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000111853 511 1800 HDGF PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B

Genomic Location for ZNF274 Gene

Chromosome:
19
Start:
58,182,989 bp from pter
End:
58,213,562 bp from pter
Size:
30,574 bases
Orientation:
Plus strand

Genomic View for ZNF274 Gene

Genes around ZNF274 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF274 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF274 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF274 Gene

Proteins for ZNF274 Gene

  • Protein details for ZNF274 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96GC6-ZN274_HUMAN
    Recommended name:
    Neurotrophin receptor-interacting factor homolog
    Protein Accession:
    Q96GC6
    Secondary Accessions:
    • Q53XU4
    • Q6MZG1
    • Q8WY37
    • Q8WY38
    • Q92969
    • Q9UII0
    • Q9UII1

    Protein attributes for ZNF274 Gene

    Size:
    653 amino acids
    Molecular mass:
    74177 Da
    Quaternary structure:
    • Interacts with SETDB1 and TRIM28/KAP1. Interacts with ATRX. Forms a complex with ATRX, SETDB1 and TRIM28 (PubMed:27029610).

    Alternative splice isoforms for ZNF274 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF274 Gene

Post-translational modifications for ZNF274 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF274 Gene

Domains & Families for ZNF274 Gene

Gene Families for ZNF274 Gene

Suggested Antigen Peptide Sequences for ZNF274 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96GC6

UniProtKB/Swiss-Prot:

ZN274_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF274: view

Function for ZNF274 Gene

Molecular function for ZNF274 Gene

UniProtKB/Swiss-Prot Function:
Probable transcription repressor. Specifically binds to the 3-end of zinc-finger coding genes and recruiting chromatin-modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression. The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610).

Gene Ontology (GO) - Molecular Function for ZNF274 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IDA 27029610
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0003714 transcription corepressor activity TAS 10777669
GO:0005515 protein binding IPI 21170338
genes like me logo Genes that share ontologies with ZNF274: view
genes like me logo Genes that share phenotypes with ZNF274: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF274 Gene

Localization for ZNF274 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF274 Gene

Cytoplasm. Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF274 gene
Compartment Confidence
nucleus 5
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for ZNF274 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IEA,TAS --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ZNF274: view

Pathways & Interactions for ZNF274 Gene

genes like me logo Genes that share pathways with ZNF274: view

Pathways by source for ZNF274 Gene

1 BioSystems pathway for ZNF274 Gene
2 Reactome pathways for ZNF274 Gene
1 KEGG pathway for ZNF274 Gene

Gene Ontology (GO) - Biological Process for ZNF274 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:1900112 regulation of histone H3-K9 trimethylation IMP 27029610
GO:1903507 negative regulation of nucleic acid-templated transcription IEA --
genes like me logo Genes that share ontologies with ZNF274: view

No data available for SIGNOR curated interactions for ZNF274 Gene

Drugs & Compounds for ZNF274 Gene

No Compound Related Data Available

Transcripts for ZNF274 Gene

Unigene Clusters for ZNF274 Gene

Zinc finger protein 274:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF274 Gene

No ASD Table

Relevant External Links for ZNF274 Gene

GeneLoc Exon Structure for
ZNF274
ECgene alternative splicing isoforms for
ZNF274

Expression for ZNF274 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF274 Gene

Protein differential expression in normal tissues from HIPED for ZNF274 Gene

This gene is overexpressed in Plasma (38.8), Pancreatic juice (18.5), and Peripheral blood mononuclear cells (10.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF274 Gene



Protein tissue co-expression partners for ZNF274 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF274 Gene:

ZNF274

SOURCE GeneReport for Unigene cluster for ZNF274 Gene:

Hs.83761

Evidence on tissue expression from TISSUES for ZNF274 Gene

  • Nervous system(4.5)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with ZNF274: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF274 Gene

Orthologs for ZNF274 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF274 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF274 34 35
  • 99.59 (n)
cow
(Bos Taurus)
Mammalia ZNF274 34 35
  • 76.99 (n)
rat
(Rattus norvegicus)
Mammalia Zfp110 34
  • 74.16 (n)
mouse
(Mus musculus)
Mammalia Zfp110 34 35
  • 74.02 (n)
Zfp369 16 35
  • 40 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 31 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 28 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Cf2 36
  • 48 (a)
CG18764 36
  • 39 (a)
Species where no ortholog for ZNF274 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF274 Gene

ENSEMBL:
Gene Tree for ZNF274 (if available)
TreeFam:
Gene Tree for ZNF274 (if available)

Paralogs for ZNF274 Gene

Paralogs for ZNF274 Gene

(260) SIMAP similar genes for ZNF274 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF274: view

Variants for ZNF274 Gene

Sequence variations from dbSNP and Humsavar for ZNF274 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000012764 -- 58,209,034(+) CAAGG(A/G)AGAAG intron-variant, upstream-variant-2KB
rs1000087855 -- 58,193,186(+) CTGTT(A/G)CCCAG intron-variant
rs1000116566 -- 58,199,691(+) CTGGC(C/T)TATGG intron-variant
rs1000181152 -- 58,184,293(+) TGTTT(-/G)GTTTT intron-variant
rs1000205213 -- 58,187,329(+) GTAAC(A/C)CTGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF274 Gene

Variant ID Type Subtype PubMed ID
esv3893260 CNV gain 25118596
nsv1066059 CNV gain 25217958
nsv833886 CNV gain 17160897

Variation tolerance for ZNF274 Gene

Gene Damage Index Score: 3.51; 55.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF274 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF274

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF274 Gene

Disorders for ZNF274 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF274 Gene - From: DISEASES

Disorder Aliases PubMed IDs
frasier syndrome
  • fs
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZNF274

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF274
genes like me logo Genes that share disorders with ZNF274: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF274 Gene

Publications for ZNF274 Gene

  1. Identification and characterization of human ZNF274 cDNA, Which encodes a novel kruppel-type zinc-finger protein having nucleolar targeting ability. (PMID: 10777669) Yano K. … Muramatsu M. (Genomics 2000) 2 3 4 22 64
  2. ATRX binds to atypical chromatin domains at the 3' exons of zinc finger genes to preserve H3K9me3 enrichment. (PMID: 27029610) Valle-Garcia D. … Bernstein E. (Epigenetics 2016) 3 4 64
  3. ZNF274 recruits the histone methyltransferase SETDB1 to the 3' ends of ZNF genes. (PMID: 21170338) Frietze S. … Farnham P.J. (PLoS ONE 2010) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D. … Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64

Products for ZNF274 Gene

Sources for ZNF274 Gene

Content
Loading form....