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Aliases for ZNF274 Gene

Aliases for ZNF274 Gene

  • Zinc Finger Protein 274 2 3 4
  • Zinc Finger Protein With KRAB And SCAN Domains 19 3 4
  • Zinc Finger Protein HFB101 3 4
  • Zinc Finger Protein Zfp2 3 4
  • ZKSCAN19 3 4
  • ZF2 3 4
  • Neurotrophin Receptor-Interacting Factor Homolog 3
  • KRAB Zinc Finger Protein HFB101 3
  • ZSCAN51 3
  • HFB101 3

External Ids for ZNF274 Gene

Previous GeneCards Identifiers for ZNF274 Gene

  • GC19P059592
  • GC19P059148
  • GC19P063370
  • GC19P063386
  • GC19P058695
  • GC19P055004

Summaries for ZNF274 Gene

Entrez Gene Summary for ZNF274 Gene

  • This gene encodes a zinc finger protein containing five C2H2-type zinc finger domains, one or two Kruppel-associated box A (KRAB A) domains, and a leucine-rich domain. The encoded protein has been suggested to be a transcriptional repressor. It localizes predominantly to the nucleolus. Alternatively spliced transcript variants encoding different isoforms exist. These variants utilize alternative polyadenylation signals. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZNF274 Gene

ZNF274 (Zinc Finger Protein 274) is a Protein Coding gene. Diseases associated with ZNF274 include denys-drash syndrome. Among its related pathways are Development HGF signaling pathway and p75(NTR)-mediated signaling. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription corepressor activity. An important paralog of this gene is ZSCAN18.

UniProtKB/Swiss-Prot for ZNF274 Gene

  • Probable transcription repressor. Specifically binds to the 3-end of zinc-finger coding genes and recruiting chromatin-modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression.

Gene Wiki entry for ZNF274 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF274 Gene

Genomics for ZNF274 Gene

Regulatory Elements for ZNF274 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF274 Gene

Start:
58,182,989 bp from pter
End:
58,213,562 bp from pter
Size:
30,574 bases
Orientation:
Plus strand

Genomic View for ZNF274 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF274 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF274 Gene

Proteins for ZNF274 Gene

  • Protein details for ZNF274 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96GC6-ZN274_HUMAN
    Recommended name:
    Neurotrophin receptor-interacting factor homolog
    Protein Accession:
    Q96GC6
    Secondary Accessions:
    • Q53XU4
    • Q6MZG1
    • Q8WY37
    • Q8WY38
    • Q92969
    • Q9UII0
    • Q9UII1

    Protein attributes for ZNF274 Gene

    Size:
    653 amino acids
    Molecular mass:
    74177 Da
    Quaternary structure:
    • Interacts with SETDB1 and TRIM28/KAP1.

    Alternative splice isoforms for ZNF274 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF274 Gene

Proteomics data for ZNF274 Gene at MOPED

Post-translational modifications for ZNF274 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF274 Gene

No data available for DME Specific Peptides for ZNF274 Gene

Domains for ZNF274 Gene

Gene Families for ZNF274 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Suggested Antigen Peptide Sequences for ZNF274 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96GC6

UniProtKB/Swiss-Prot:

ZN274_HUMAN :
  • Q96GC6
Domain:
  • Contains 2 KRAB domains.
  • Contains 1 SCAN box domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 5 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF274: view

Function for ZNF274 Gene

Molecular function for ZNF274 Gene

UniProtKB/Swiss-Prot Function: Probable transcription repressor. Specifically binds to the 3-end of zinc-finger coding genes and recruiting chromatin-modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression.

Gene Ontology (GO) - Molecular Function for ZNF274 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0003714 transcription corepressor activity TAS 10777669
GO:0005515 protein binding IPI 21170338
GO:0043565 sequence-specific DNA binding IDA 21170338
genes like me logo Genes that share ontologies with ZNF274: view
genes like me logo Genes that share phenotypes with ZNF274: view

Animal Models for ZNF274 Gene

MGI Knock Outs for ZNF274:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF274 Gene

Localization for ZNF274 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF274 Gene

Cytoplasm. Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF274 Gene COMPARTMENTS Subcellular localization image for ZNF274 gene
Compartment Confidence
nucleus 5
cytoskeleton 4

Gene Ontology (GO) - Cellular Components for ZNF274 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ZNF274: view

Pathways for ZNF274 Gene

genes like me logo Genes that share pathways with ZNF274: view

Pathways by source for ZNF274 Gene

1 BioSystems pathway for ZNF274 Gene
2 Reactome pathways for ZNF274 Gene
1 KEGG pathway for ZNF274 Gene

Gene Ontology (GO) - Biological Process for ZNF274 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:1903507 negative regulation of nucleic acid-templated transcription TAS 10777669
genes like me logo Genes that share ontologies with ZNF274: view

Transcripts for ZNF274 Gene

Unigene Clusters for ZNF274 Gene

Zinc finger protein 274:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF274

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF274 Gene

No ASD Table

Relevant External Links for ZNF274 Gene

GeneLoc Exon Structure for
ZNF274
ECgene alternative splicing isoforms for
ZNF274

Expression for ZNF274 Gene

mRNA expression in normal human tissues for ZNF274 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZNF274 Gene

SOURCE GeneReport for Unigene cluster for ZNF274 Gene Hs.83761

genes like me logo Genes that share expressions with ZNF274: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF274 Gene

Orthologs for ZNF274 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF274 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF274 35
  • 99.59 (n)
  • 99.69 (a)
ZNF274 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF274 35
  • 76.99 (n)
  • 71.47 (a)
ZNF274 36
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp110 35
  • 74.02 (n)
  • 62.79 (a)
Zfp110 16
Zfp110 36
  • 41 (a)
OneToMany
Zfp369 36
  • 40 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 31 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Zfp110 35
  • 74.16 (n)
  • 62.42 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 28 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Cf2 37
  • 48 (a)
CG18764 37
  • 39 (a)
Species with no ortholog for ZNF274:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF274 Gene

ENSEMBL:
Gene Tree for ZNF274 (if available)
TreeFam:
Gene Tree for ZNF274 (if available)

Paralogs for ZNF274 Gene

Paralogs for ZNF274 Gene

Selected SIMAP similar genes for ZNF274 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF274: view

Variants for ZNF274 Gene

Sequence variations from dbSNP and Humsavar for ZNF274 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs75597 -- 58,208,870(+) AATTC(A/G)CCCTG intron-variant
rs101447 -- 58,209,351(+) GGGGT(A/G)GATTA intron-variant
rs157355 -- 58,181,319(-) gtttc(A/T)ccatg upstream-variant-2KB
rs157356 -- 58,182,209(+) ATACT(A/G)GGACC upstream-variant-2KB
rs157357 -- 58,182,503(+) TAGGG(C/T)AGACG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNF274 Gene

Variant ID Type Subtype PubMed ID
nsv912536 CNV Gain 21882294
nsv833886 CNV Gain 17160897
nsv912537 CNV Loss 21882294

Relevant External Links for ZNF274 Gene

HapMap Linkage Disequilibrium report
ZNF274

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF274 Gene

Disorders for ZNF274 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ZNF274 Gene including...

Search for ZNF274 Gene in MalaCards »

(1) University of Copenhagen DISEASES for ZNF274 Gene

genes like me logo Genes that share disorders with ZNF274: view

No data available for UniProtKB/Swiss-Prot for ZNF274 Gene

Publications for ZNF274 Gene

  1. Identification and characterization of human ZNF274 cDNA, Which encodes a novel kruppel-type zinc-finger protein having nucleolar targeting ability. (PMID: 10777669) Yano K. … Muramatsu M. (Genomics 2000) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D. … Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  4. Computer sequence analysis of human highly conserved zinc finger modules. (PMID: 10520746) Petroni D. … Comi P. (DNA Seq. 1998) 3 4
  5. ZNF274 recruits the histone methyltransferase SETDB1 to the 3' ends of ZNF genes. (PMID: 21170338) Frietze S. … Farnham P.J. (PLoS ONE 2010) 3 4

Products for ZNF274 Gene

Sources for ZNF274 Gene

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