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Aliases for ZNF273 Gene

Aliases for ZNF273 Gene

  • Zinc Finger Protein 273 2 3
  • Zinc Finger Protein HZF9 3 4
  • Zinc Finger Protein 9 3
  • HZF9 3

External Ids for ZNF273 Gene

Previous GeneCards Identifiers for ZNF273 Gene

  • GC07P062915
  • GC07P063027
  • GC07P063785
  • GC07P063686
  • GC07P063087
  • GC07P063808
  • GC07P064001
  • GC07P064330
  • GC07P060743

Summaries for ZNF273 Gene

Entrez Gene Summary for ZNF273 Gene

  • This gene is a member of the krueppel C2H2-type zinc-finger protein family and encodes a protein with 13 C2H2-type zinc fingers and a KRAB domain. This nuclear protein is involved in transcriptional regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZNF273 Gene

ZNF273 (Zinc Finger Protein 273) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF253.

UniProtKB/Swiss-Prot for ZNF273 Gene

  • May be involved in transcriptional regulation

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF273 Gene

Genomics for ZNF273 Gene

Regulatory Elements for ZNF273 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF273 Gene

Start:
64,870,172 bp from pter
End:
64,931,577 bp from pter
Size:
61,406 bases
Orientation:
Plus strand

Genomic View for ZNF273 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF273 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF273 Gene

Proteins for ZNF273 Gene

  • Protein details for ZNF273 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14593-ZN273_HUMAN
    Recommended name:
    Zinc finger protein 273
    Protein Accession:
    Q14593
    Secondary Accessions:
    • B3KQZ5
    • Q6P3V4

    Protein attributes for ZNF273 Gene

    Size:
    569 amino acids
    Molecular mass:
    64971 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF273 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF273 Gene

Proteomics data for ZNF273 Gene at MOPED

Post-translational modifications for ZNF273 Gene

  • Ubiquitination at Lys130 and Lys521
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF273 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF273 Gene

Domains for ZNF273 Gene

Gene Families for ZNF273 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF273 Gene

Suggested Antigen Peptide Sequences for ZNF273 Gene

Graphical View of Domain Structure for InterPro Entry

Q14593

UniProtKB/Swiss-Prot:

ZN273_HUMAN :
  • Q14593
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 13 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF273: view

Function for ZNF273 Gene

Molecular function for ZNF273 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF273 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF273: view

Phenotypes for ZNF273 Gene

GenomeRNAi human phenotypes for ZNF273:
genes like me logo Genes that share phenotypes with ZNF273: view

Animal Model Products

CRISPR Products

miRNA for ZNF273 Gene

miRTarBase miRNAs that target ZNF273

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF273

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF273 Gene

Localization for ZNF273 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF273 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF273 Gene COMPARTMENTS Subcellular localization image for ZNF273 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for ZNF273 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF273: view

Pathways for ZNF273 Gene

SuperPathways for ZNF273 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF273: view

Pathways by source for ZNF273 Gene

2 Reactome pathways for ZNF273 Gene

Gene Ontology (GO) - Biological Process for ZNF273 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF273: view

Transcripts for ZNF273 Gene

Unigene Clusters for ZNF273 Gene

Zinc finger protein 273:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF273

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ZNF273
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF273 Gene

No ASD Table

Relevant External Links for ZNF273 Gene

GeneLoc Exon Structure for
ZNF273
ECgene alternative splicing isoforms for
ZNF273

Expression for ZNF273 Gene

mRNA expression in normal human tissues for ZNF273 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF273 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (6.9), Brain - Cerebellum (4.8), Skin - Sun Exposed (Lower leg) (4.5), and Brain - Cerebellar Hemisphere (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF273 Gene

SOURCE GeneReport for Unigene cluster for ZNF273 Gene Hs.520889

genes like me logo Genes that share expressions with ZNF273: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ZNF273 Gene

Orthologs for ZNF273 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF273 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF273 35
  • 99.47 (n)
  • 99.12 (a)
ZNF273 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 54 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 38 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Zfp273 16
Zfp493 36
  • 59 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 37 (a)
ManyToMany
-- 36
  • 49 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 50 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
-- 36
  • 40 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
-- 36
  • 31 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
Species with no ortholog for ZNF273:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF273 Gene

ENSEMBL:
Gene Tree for ZNF273 (if available)
TreeFam:
Gene Tree for ZNF273 (if available)

Paralogs for ZNF273 Gene

Selected SIMAP similar genes for ZNF273 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZNF273: view

Variants for ZNF273 Gene

Sequence variations from dbSNP and Humsavar for ZNF273 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs3663 -- 64,929,100(+) GATAA(G/T)TCATA utr-variant-3-prime, nc-transcript-variant
rs871076 -- 64,892,914(-) ATGCA(G/T)CTCAG upstream-variant-2KB
rs871077 -- 64,892,738(-) gccct(A/G)tgtaa upstream-variant-2KB
rs1405008 -- 64,931,746(-) ATAGA(C/T)CAAGC downstream-variant-500B
rs1405009 -- 64,931,590(-) AAGTC(A/G)GCTTA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for ZNF273 Gene

Variant ID Type Subtype PubMed ID
dgv1147e201 CNV Deletion 23290073
esv2422405 CNV Duplication 17116639
nsv464518 CNV Gain 19166990
dgv7308n71 CNV Gain 21882294
esv2734581 CNV Deletion 23290073
esv2677316 CNV Deletion 23128226
nsv508457 CNV Loss 20534489
dgv7309n71 CNV Gain 21882294
dgv226e55 CNV Loss 17911159
nsv510085 CNV Loss 20534489

Relevant External Links for ZNF273 Gene

HapMap Linkage Disequilibrium report
ZNF273

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF273 Gene

Disorders for ZNF273 Gene

No disorders were found for ZNF273 Gene.

No data available for UniProtKB/Swiss-Prot for ZNF273 Gene

Publications for ZNF273 Gene

  1. Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937. (PMID: 7865130) Abrink M. … Hellman L. (DNA Cell Biol. 1995) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. An atlas of combinatorial transcriptional regulation in mouse and man. (PMID: 20211142) Ravasi T. … Hayashizaki Y. (Cell 2010) 3

Products for ZNF273 Gene

Sources for ZNF273 Gene

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