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ZNF273 Gene

protein-coding   GIFtS: 49
GCID: GC07P064330

Zinc Finger Protein 273

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Aliases
for ZNF273 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 2731 2
Zinc Finger Protein HZF92 3
HZF92
Zinc Finger Protein 92

External Ids:    HGNC: 130671   Entrez Gene: 107932   Ensembl: ENSG000001980397   OMIM: 6047565   UniProtKB: Q145933   

Export aliases for ZNF273 gene to outside databases

Previous GC identifers: GC07P062915 GC07P063027 GC07P063785 GC07P063686 GC07P063087 GC07P063808 GC07P064001 GC07P060743


Summaries
for ZNF273 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ZNF273 Gene:
This gene is a member of the krueppel C2H2-type zinc-finger protein family and encodes a protein with 13 C2H2-type
zinc fingers and a KRAB domain. This nuclear protein is involved in transcriptional regulation. Alternative
splicing results in multiple transcript variants. (provided by RefSeq, Jul 2008)

GeneCards Summary for ZNF273 Gene:
ZNF273 (zinc finger protein 273) is a protein-coding gene. An important paralog of this gene is ZNF85.

UniProtKB/Swiss-Prot: ZN273_HUMAN, Q14593
Function: May be involved in transcriptional regulation




Genomic Views
for ZNF273 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF273 gene promoter:
         GR   Hand1   GR-alpha   E47   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): ZNF273 promoter sequence
   Search Chromatin IP Primers for ZNF273

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF273


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q11.21   Ensembl cytogenetic band:  7q11.21   HGNC cytogenetic band: 7q11.21

ZNF273 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF273 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P064330:  view genomic region     (about GC identifiers)

Start:
 64,330,550 bp from pter      End:
 64,391,955 bp from pter
Size:
 61,406 bases      Orientation:
 plus strand

1 alternative location:
Chr7+,CRA_TCAG 63,701,214-63,729,549     

Proteins
for ZNF273 gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZN273_HUMAN, Q14593 (See protein sequence)
Recommended Name: Zinc finger protein 273  
Size: 569 amino acids; 64971 Da
Secondary accessions: B3KQZ5 Q6P3V4
Alternative splicing: 2 isoforms:  Q14593-1   Q14593-2   (No experimental confirmation available. Derived from EST data)

Explore the universe of human proteins at neXtProt for ZNF273: NX_Q14593

Explore proteomics data for ZNF273 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys130, Lys521
  • Modification sites at PhosphoSitePlus

    • See ZNF273 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_066971.2  
    ENSEMBL proteins: 
     ENSP00000418719   ENSP00000433382   ENSP00000440725   ENSP00000324518  
    Reactome Protein details: Q14593

    ZNF273 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ZNF273

         		 Search eBioscience for Proteins for ZNF273 

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    antibodies-online kits for ZNF273 (2 products) 

    Domains /
    Families
    for ZNF273 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus    		 HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q14593

    ProtoNet protein and cluster: Q14593

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN273_HUMAN, Q14593
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 13 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    Find genes that share domains with ZNF273           About GenesLikeMe


    Function
    for ZNF273 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN273_HUMAN, Q14593
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF273           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF273:
     Decreased circadian period len 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ZNF273

    miRNA
    Products:            		miRTarBase miRNAs that target ZNF273:
    hsa-mir-192-5p (MIRT026919), hsa-mir-155-5p (MIRT021054), hsa-mir-215-5p (MIRT024753)

    Block miRNA regulation of human, mouse, rat ZNF273 using miScript Target Protectors
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    Gene Editing
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    In Situ Assay
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    Localization
    for ZNF273 gene

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN273_HUMAN, Q14593: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZNF273           About GenesLikeMe


    Pathways & Interactions
    for ZNF273 gene

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF273 About    
    See pathways by source

    		      Powered
    by    		     
    SuperPathContained pathways About
    1Gene Expression
    		Generic Transcription Pathway0.40
    		Gene Expression0.40


    Find genes that share SuperPaths with ZNF273           About GenesLikeMe

    Pathways by source                                   See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF273
        Generic Transcription Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF273
    Interactions:

        Search GeneGlobe Interaction Network for ZNF273

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for ZNF273 (Q145933 ENSP000004187194) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SP8Q8IXZ33, ENSP000004087924I2D: score=1 STRING: ENSP00000408792
    CA14ENSP000003581074STRING: ENSP00000358107
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with ZNF273           About GenesLikeMe



    Drugs & Compounds
    for ZNF273 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF273 (ZN273)



    Transcripts
    for ZNF273 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF273 gene (2 alternative transcripts): 
    NM_021148.2  NM_033548.1  

    Unigene Cluster for ZNF273:

    Zinc finger protein 273
    Hs.520889  [show with all ESTs]
    Unigene Representative Sequence: NR_003099
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000476730(uc003ttk.1) ENST00000465954 ENST00000527278 ENST00000471926
    ENST00000476120 ENST00000489672(uc003ttm.1 uc003ttp.1) ENST00000395375(uc003ttl.3 uc003ttn.3 uc003tto.3)
    ENST00000545510 ENST00000319636
    miRNA
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    Inhib. RNA
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    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat ZNF273

    Additional mRNA sequence: 

    AL832810.1 BC007078.1 BC008386.1 BC019234.1 BC041102.1 BC063818.1 BC108740.1 NR_003099.1 
    X78932.1 

    9 DOTS entries:

    DT.100683764  DT.91733084  DT.92431203  DT.100030166  DT.207182  DT.75162488  DT.40219894  DT.121053206 
    DT.121496672 

    Selected AceView cDNA sequences (see all 64):

    BC007078 N81189 AW172914 BF223897 BC019234 BQ575139 N22289 NM_033548 
    BE958523 AU132789 BG530224 BC041102 BM465909 AL832810 BX103065 AV723589 
    BX475233 BG060114 BC008386 NM_021148 AX746558 BG502210 BG532323 BG532890 

    GeneLoc Exon Structure


    Expression
    for ZNF273 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF273 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZNF273 Expression
    About this image

    ZNF273 Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

    ZNF273 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.520889
        Custom PCR Arrays for ZNF273
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    In Situ
    Assay Products:     
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    Orthologs
    for ZNF273 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF273 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Zfp2735 zinc finger protein 273   --   13 (34.80 cM) 67813740 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    (see all 8)    		 Uncharacterized protein
    (see all 8)    		 50(a)
    40(a)
    (see all 8)    		 many ↔ many
    many ↔ many
    (see all 8)    		 AAWZ02037240(11818-13836)
    GL343434.1(292314-296903)


    ENSEMBL Gene Tree for ZNF273 (if available)
    TreeFam Gene Tree for ZNF273 (if available)

    Paralogs
    for ZNF273 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF273 gene
    ZNF852  ZNF4862  ZNF1952  ZNF922  ZNF1002  ZNF7322  ZNF6752  ZNF1382  
    ZNF5062  ZNF662  ZNF6952  ZNF6262  ZNF6802  ZNF4792  ZNF2532  ZNF932  
    ZNF6822  ZNF4922  ZNF6762  ZNF6812  ZNF1412  ZNF7362  ZNF6792  ZNF2572  
    ZNF2542  ZNF7372  ZNF724P2  ZNF982  ZNF7162  ZNF7142  ZNF4292  ZNF5192  
    ZNF4302  ZNF7302  ZNF7082  ZNF1172  ZNF4312  ZNF902  ZNF7262  ZNF7282  
    Selected SIMAP similar genes for ZNF273 using alignment to 4 protein entries:     ZN273_HUMAN (see all proteins) (see all similar genes):
    MGC12518    ZNF257    ZNF724P    ZNF98    ZNF430    ZNF506
    ZNF100    ZNF429    ZNF738    ZFS-4    ZNF90    ZNF680
    ZNF492    ZNF729    ZNF66    ZNF43    ZNF737    ZNF254

    Find genes that share paralogs with ZNF273           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for ZNF273 (see all 13)
    PGOHUM00000242763 PGOHUM00000239813 PGOHUM00000258059 PGOHUM00000246386 PGOHUM00000240248


    Genomic Variants
    for ZNF273 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF273 (see all 713)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs102638761,2
    		C,F,A,H--64361812(+) GAGTTC/AAGCCT 2 -- us2k125Minor allele frequency- A:0.40NS EA NA WA CSA 2478
    rs1448921631,2
    		--64361894(+) AATGAA/GTCCTT 2 -- us2k10--------
    rs102640261,2
    		C,F--64361941(+) CAGGTC/AGTGAT 2 -- us2k110Minor allele frequency- A:0.43NA WA CSA EA 371
    rs768971011,2
    		C,F--64362005(+) AGTGAG/AACCCT 2 -- us2k11Minor allele frequency- A:0.03WA 118
    rs102825991,2
    		C,F--64362012(+) CCCTCT/ATTTCT 2 -- us2k1 trp38Minor allele frequency- A:0.43WA NA CSA EA 368
    rs1911870051,2
    		--64362100(+) GAGGCA/GGGCGG 2 -- us2k10--------
    rs1479631451,2
    		--64362109(+) GGATCA/CCATGA 2 -- us2k10--------
    rs1857287481,2
    		--64362130(+) TCGAGA/TCCAGC 2 -- us2k10--------
    rs1905881881,2
    		--64362167(+) CTACTA/GAAAAT 2 -- us2k10--------
    rs19661401,2
    		C,F,A--64362191(-) GCCATC/TGTGCC 2 -- us2k18Minor allele frequency- T:0.36NA CSA WA EA 368

    HapMap Linkage Disequilibrium report for ZNF273 (64330550 - 64391955 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for ZNF273:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1147e201CNV Deletion23290073
    esv2677316CNV Deletion23128226
    esv2734581CNV Deletion23290073
    esv2422405CNV Duplication17116639
    nsv510085CNV Loss20534489
    nsv508457CNV Loss20534489
    dgv226e55CNV Loss17911159
    dgv7308n71CNV Gain21882294
    dgv7309n71CNV Gain21882294
    nsv464518CNV Gain19166990

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    Disorders / Diseases
    for ZNF273 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus    		 OMIM gene information: 604756    OMIM disorders: --


    Find genes that share disorders with ZNF273           About GenesLikeMe


    Export disorders for ZNF273 gene to outside databases

    Publications
    for ZNF273 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for ZNF273 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with ZNF273)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937. (PubMed id 7865130)1, 2, 3 Abrink M.... Hellman L. (DNA Cell Biol. 1995)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    5. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    6. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    7. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (Cell 2010)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    9. The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (Nature 2003)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    External Searches for ZNF273 gene

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    Genome Databases showing ZNF273 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10793 HGNC: 13067 AceView: ZNF273 Ensembl:ENSG00000198039 euGenes: HUgn10793
    ECgene: ZNF273 H-InvDB: ZNF273

    Other Databases showing ZNF273 gene

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    Specialized Databases showing ZNF273 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    PharmGKB entry for ZNF273 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
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