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Aliases for ZNF273 Gene

Aliases for ZNF273 Gene

  • Zinc Finger Protein 273 2 3 5
  • Zinc Finger Protein HZF9 3 4
  • Zinc Finger Protein 9 3
  • HZF9 3

External Ids for ZNF273 Gene

Previous GeneCards Identifiers for ZNF273 Gene

  • GC07P062915
  • GC07P063027
  • GC07P063785
  • GC07P063686
  • GC07P063087
  • GC07P063808
  • GC07P064001
  • GC07P064330
  • GC07P060743

Summaries for ZNF273 Gene

Entrez Gene Summary for ZNF273 Gene

  • This gene is a member of the krueppel C2H2-type zinc-finger protein family and encodes a protein with 13 C2H2-type zinc fingers and a KRAB domain. This nuclear protein is involved in transcriptional regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZNF273 Gene

ZNF273 (Zinc Finger Protein 273) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF429.

UniProtKB/Swiss-Prot for ZNF273 Gene

  • May be involved in transcriptional regulation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF273 Gene

Genomics for ZNF273 Gene

Regulatory Elements for ZNF273 Gene

Enhancers for ZNF273 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F064887 1 Ensembl ENCODE 9.2 +18.6 18595 2.1 CTCF ZNF792 SUZ12 SAP130 ARID4B ZNF48 RAD21 HBP1 GATAD1 CBX5 EEF1DP4 ZNF273 ZNF117 ENSG00000234338 LOC441239
GH07F064902 1 ENCODE 7.5 +33.3 33273 2.3 HDGF ATF1 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF48 YY1 ZNF143 EEF1DP4 ZNF117 ZNF273 LOC441239 VN1R42P
GH07F065079 1.2 Ensembl ENCODE 5.2 +210.9 210855 2.5 HDGF PKNOX1 ATF1 ARID4B SIN3A DMAP1 ZNF48 BRCA1 ZNF2 YY1 GTF2IP14 INTS4P1 CCT6P3 ZNF117 ZNF273 ERV3-1 ENSG00000227113
GH07F064908 0.8 Ensembl ENCODE 7.2 +37.7 37709 1.3 IKZF1 ZSCAN29 KDM1A ZNF18 EEF1DP4 ZNF273 LOC441239 VN1R42P
GH07F064947 0.7 Ensembl 7.8 +77.4 77429 0.8 KLF1 SP3 ZFP64 ZBTB8A ZNF48 ZIC2 GLIS2 ZFHX2 KLF16 GABPB1 VKORC1L1 ZNF273 LOC105375328 PIR39696
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF273 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF273 Gene

Chromosome:
7
Start:
64,870,172 bp from pter
End:
64,932,239 bp from pter
Size:
62,068 bases
Orientation:
Plus strand

Genomic View for ZNF273 Gene

Genes around ZNF273 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF273 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF273 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF273 Gene

Proteins for ZNF273 Gene

  • Protein details for ZNF273 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14593-ZN273_HUMAN
    Recommended name:
    Zinc finger protein 273
    Protein Accession:
    Q14593
    Secondary Accessions:
    • B3KQZ5
    • Q6P3V4

    Protein attributes for ZNF273 Gene

    Size:
    569 amino acids
    Molecular mass:
    64971 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF273 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF273 Gene

Post-translational modifications for ZNF273 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF273 Gene

Domains & Families for ZNF273 Gene

Gene Families for ZNF273 Gene

Protein Domains for ZNF273 Gene

Suggested Antigen Peptide Sequences for ZNF273 Gene

Graphical View of Domain Structure for InterPro Entry

Q14593

UniProtKB/Swiss-Prot:

ZN273_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 13 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 13 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF273: view

Function for ZNF273 Gene

Molecular function for ZNF273 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF273 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IBA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF273: view
genes like me logo Genes that share phenotypes with ZNF273: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF273 Gene

Localization for ZNF273 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF273 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF273 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZNF273 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA,IBA --
genes like me logo Genes that share ontologies with ZNF273: view

Pathways & Interactions for ZNF273 Gene

SuperPathways for ZNF273 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF273: view

Pathways by source for ZNF273 Gene

2 Reactome pathways for ZNF273 Gene

Gene Ontology (GO) - Biological Process for ZNF273 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF273: view

No data available for SIGNOR curated interactions for ZNF273 Gene

Transcripts for ZNF273 Gene

Unigene Clusters for ZNF273 Gene

Zinc finger protein 273:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF273 Gene

No ASD Table

Relevant External Links for ZNF273 Gene

GeneLoc Exon Structure for
ZNF273
ECgene alternative splicing isoforms for
ZNF273

Expression for ZNF273 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF273 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZNF273 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x6.9), Brain - Cerebellum (x4.8), Skin - Sun Exposed (Lower leg) (x4.5), and Brain - Cerebellar Hemisphere (x4.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF273 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZNF273 Gene:

ZNF273

SOURCE GeneReport for Unigene cluster for ZNF273 Gene:

Hs.520889
genes like me logo Genes that share expression patterns with ZNF273: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ZNF273 Gene

Orthologs for ZNF273 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF273 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF273 34 35
  • 99.47 (n)
mouse
(Mus musculus)
Mammalia Zfp493 35
  • 59 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 54 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 49 (a)
ManyToMany
-- 35
  • 37 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 38 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 50 (a)
ManyToMany
-- 35
  • 40 (a)
ManyToMany
-- 35
  • 39 (a)
ManyToMany
-- 35
  • 33 (a)
ManyToMany
-- 35
  • 31 (a)
ManyToMany
-- 35
  • 30 (a)
ManyToMany
-- 35
  • 30 (a)
ManyToMany
-- 35
  • 30 (a)
ManyToMany
Species where no ortholog for ZNF273 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF273 Gene

ENSEMBL:
Gene Tree for ZNF273 (if available)
TreeFam:
Gene Tree for ZNF273 (if available)

Paralogs for ZNF273 Gene

(535) SIMAP similar genes for ZNF273 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZNF273: view

Variants for ZNF273 Gene

Sequence variations from dbSNP and Humsavar for ZNF273 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10085423 -- 64,913,786(+) CATTA(A/C)ATAGA intron-variant
rs10224118 -- 64,880,835(+) CCCAG(C/G)AGTCC upstream-variant-2KB
rs10225010 -- 64,916,410(+) agcgg(C/T)ggcag intron-variant
rs10226807 -- 64,912,524(+) taaag(G/T)gcaca intron-variant
rs10231738 -- 64,888,362(+) GGAAG(C/T)GGGTT intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ZNF273 Gene

Variant ID Type Subtype PubMed ID
nsv981497 CNV duplication 23825009
nsv970504 CNV duplication 23825009
nsv607312 CNV gain 21841781
nsv510085 OTHER sequence alteration 20534489
nsv508457 CNV deletion 20534489
nsv464518 CNV gain 19166990
nsv1026390 CNV gain 25217958
nsv1022042 CNV gain 25217958
nsv1019180 CNV loss 25217958
nsv1018967 CNV gain 25217958
esv3541778 CNV deletion 23714750
esv2677316 CNV deletion 23128226
esv2422405 CNV duplication 17116639
dgv3575n106 CNV deletion 24896259
dgv226e55 CNV loss 17911159
dgv1099e201 CNV deletion 23290073

Variation tolerance for ZNF273 Gene

Residual Variation Intolerance Score: 53.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.21; 90.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF273 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF273

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF273 Gene

Disorders for ZNF273 Gene

Relevant External Links for ZNF273

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF273

No disorders were found for ZNF273 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF273 Gene

Publications for ZNF273 Gene

  1. Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937. (PMID: 7865130) Abrink M. … Hellman L. (DNA Cell Biol. 1995) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64

Products for ZNF273 Gene

Sources for ZNF273 Gene

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