ZNF273 Gene
protein-coding GIFtS: 48
GCID: GC07P064330
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|
zinc finger protein 273
| |
Aliases
for ZNF273 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 2731 2 | | HZF91 2 | | Zinc Finger Protein HZF92 3 | | Zinc Finger Protein 92 |
Export aliases for ZNF273 gene to outside databasesPrevious GC identifers: GC07P062915 GC07P063027 GC07P063785 GC07P063686 GC07P063087 GC07P063808 GC07P064001 GC07P060743 |
Summaries
for ZNF273 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ZNF273:
This gene is a member of the krueppel C2H2-type zinc-finger protein family and encodes a protein with 13 C2H2-type zincfingers and a KRAB domain. This nuclear protein is involved in transcriptional regulation. Alternative splicingresults in multiple transcript variants. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: ZN273_HUMAN, Q14593Function: May be involved in transcriptional regulation
|
Genomic Views
for ZNF273 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079593.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF273 gene promoter:
GR Hand1 GR-alpha E47 GATA-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF273
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF273 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q11.21 Ensembl cytogenetic band: 7q11.21 HGNC cytogenetic band: 7q11.21ZNF273 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P064330: view genomic region
(about GC identifiers)
Start:
|
64,330,550 bp from pter |
End:
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64,391,955 bp from pter |
Size:
|
61,406 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 63,701,214-63,729,549 |
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Proteins
for ZNF273 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN273_HUMAN, Q14593 (See
protein sequence)Recommended Name: Zinc finger protein 273 Size: 569 amino acids; 64971 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: B3KQZ5 Q6P3V4Alternative splicing: 2 isoforms: Q14593-1 Q14593-2 (No experimental confirmation available. Derived from EST data)Explore the universe of human proteins at neXtProt for ZNF273: NX_Q14593
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q14593
ZNF273 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_066971.2
ENSEMBL proteins: ENSP00000418719 ENSP00000433382 ENSP00000440725 ENSP00000324518 Reactome Protein details: Q14593
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZNF273 for ontologies About GeneDecksing
ZNF273 Antibody Products:
Assay Products for ZNF273: |
Protein
Domains /
Families
for ZNF273 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF273 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q14593ProtoNet protein and cluster: Q14593 1 Blocks protein family: IPB001909 KRAB box
UniProtKB/Swiss-Prot: ZN273_HUMAN, Q14593Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 13 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF273 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZN273_HUMAN, Q14593Function: May be involved in transcriptional regulation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF273 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF273
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF273 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZNF273 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ZNF273:
|
Pathways & Interactions
for ZNF273 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF273
ZNF273 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF273
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for ZNF273 (Q145933 ENSP000004187194) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF273 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF273 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF273
Search CenterWatch for drugs/clinical trials and news about ZNF273 / ZN273
|
Transcripts
for ZNF273 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF273 gene (2 alternative transcripts): NM_021148.2 NM_033548.1 Unigene Cluster for ZNF273: Zinc finger protein 273 Hs.520889 [show with all ESTs]Unigene Representative Sequence: NR_0030999 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000476730(uc003ttk.1) ENST00000465954 ENST00000527278 ENST00000471926
ENST00000476120 ENST00000489672(uc003ttm.1 uc003ttp.1) ENST00000395375(uc003ttl.3 uc003ttn.3 uc003tto.3)
ENST00000545510 ENST00000319636
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF273 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF273
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF273 (NM_021148) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF273 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF273 |
Additional cDNA sequence: AL832810.1 BC007078.1 BC008386.1 BC019234.1 BC041102.1 BC063818.1 BC108740.1 NR_003099.1 X78932.1 9 DOTS entries: DT.100683764 DT.91733084 DT.92431203 DT.100030166 DT.207182 DT.75162488 DT.40219894 DT.121053206 DT.121496672 24/64 AceView cDNA sequences (see all 64): BF223897 N81189 AW172914 N22289 BC019234 BC007078 BQ575139 AU132789 BX096072 BG391074 BU183131 AK090648 BG532890 BE958523 NM_033548 BU509612 BG060114 BX103065 AV723589 BC008386 AL832810 BX475233 NM_021148 AX746558
GeneLoc Exon Structure
|
Expression
for ZNF273 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF273 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See ZNF273 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF273
SOURCE GeneReport for Unigene cluster: Hs.520889
SABiosciences Custom PCR Arrays for ZNF273
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF273
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZNF273 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF273 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF273 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF273 |
Orthologs
for ZNF273 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZNF273 gene from 1/4 species (see all 4) About this table
ENSEMBL Gene Tree for ZNF273 (if available)
TreeFam Gene Tree for ZNF273 (if available) |
Paralogs
for ZNF273 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF273 gene
- ZNF852 ZNF4932 ZNF4862 ZNF1002 ZNF922 ZNF7322 ZNF1382 ZNF6752
- ZNF5062 ZNF66P2 ZNF6952 ZNF6262 ZNF6802 ZNF2532 ZNF4792 ZNF932
- ZNF4922 ZNF6822 ZNF6762 ZNF1412 ZNF6812 ZNF6792 ZNF2572 ZNF2542
- ZNF7372 ZNF724P2 ZNF982 ZNF849P2 ZNF7162 ZNF7142 ZNF4292 ZNF4302
- ZNF7302 ZNF6782 ZNF1172 ZNF7082 ZNF1072 ZNF4312 ZNF902
18/524 SIMAP similar genes for ZNF273 using alignment to 4 protein entries: ZN273_HUMAN (see all proteins)
(see all similar genes):MGC12518 ZNF506 ZNF724P ZFS-4 ZNF429 ZNF430
ZNF737 ZNF98 ZNF90 ZNF738 ZNF680 ZNF708
ZNF100 ZNF492 ZNF66 ZNF729 ZNF66P ZNF254
ZNF273 for paralogs About GeneDecksing
5/13 Pseudogenes.org Pseudogenes for ZNF273 (see all 13)
PGOHUM00000242763 PGOHUM00000239813 PGOHUM00000258059 PGOHUM00000246386 PGOHUM00000240248
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Genomic Variants
for ZNF273 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF273 (64330550 - 64391955 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for ZNF273
2 CNVs: 9059 5239 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF273 |
|
Disorders
/ Diseases
for ZNF273 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 ZNF273 for disorders About MalaCards
ZNF273 for disorders About GeneDecksing
OMIM gene information: 604756
OMIM disorders: --
Export disorders for ZNF273 gene to outside databases
|
Publications
for ZNF273 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF273 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF273) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937. (PubMed id 7865130)1, 2, 3 Abrink M.... Hellman L. (1995)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Toward a complete human genome sequence. (PubMed id 9847074)1 Wilson R. (1998)
|
External Searches for ZNF273 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF273 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF273 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF273 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF273 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF273 gene:
Search GeneIP for patents involving ZNF273
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF273 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF273 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF273 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF273 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF273 | | OriGene 3'-UTR Clone for ZNF273 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF273 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF273 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ZNF273 | | OriGene Custom Protein Services for ZNF273 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF273 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF273 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF273 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF273 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF273 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF273 |
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 |  |  |  | |
| | | | Search Tocris compounds for ZNF273 |
| |  |  |  |  | | | | |
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 | | | ZNF273 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF273 |
|  |  |  | | | | ThermoFisher Antibody for ZNF273 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF273 |
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