ZNF273 Gene

Aliases
for ZNF273 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC07P062915 GC07P063027 GC07P063785 GC07P063686 GC07P063087 GC07P063808 GC07P064001 GC07P060743

Summaries
for ZNF273 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for ZNF273 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000007.13  NT_007933.16  NC_018918.2  

SwitchGear Promoter luciferase reporter plasmids (see all 4): ZNF273 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF273

ZNF273 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P064330:  view genomic region     (about GC identifiers)

Proteins
for ZNF273 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for ZNF273: NX_Q14593

Explore proteomics data for ZNF273 at MOPED

Post-translational modifications: 

ZNF273 Human Recombinant Protein Products:

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ZNF273 Assay Products:

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	antibodies-online kits for ZNF273 (2 products)

Domains /
Families
for ZNF273 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q14593

Find genes that share domains with ZNF273           About GenesLikeMe

Function
for ZNF273 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 3 molecular function terms:    About this table

genOway: Develop your customized and physiologically relevant rodent model for ZNF273

miRNA Products:		miRTarBase miRNAs that target ZNF273: hsa-mir-192-5p (MIRT026919), hsa-mir-155-5p (MIRT021054), hsa-mir-215-5p (MIRT024753)
		Block miRNA regulation of human, mouse, rat ZNF273 using miScript Target Protectors
		Search for qRT-PCR Assays for microRNAs that regulate ZNF273
		SwitchGear 3'UTR luciferase reporter plasmid: ZNF273 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for ZNF273
		Predesigned siRNA for gene silencing in human, mouse, rat ZNF273

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for ZNF273

Clone Products:		OriGene clones in human, mouse for ZNF273 (see all 6) OriGene ORF clones in mouse, rat for ZNF273 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ZNF273 (NM_021148)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZNF273
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF273

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ZNF273
		Browse ESI BIO Cell Lines and PureStem Progenitors for ZNF273

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF273

Localization
for ZNF273 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
nucleus	4

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Gene Ontology (GO): 2 cellular component terms:    About this table

Pathways & Interactions
for ZNF273 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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SuperPaths for ZNF273 About     See pathways by source

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	SuperPath	Contained pathways About
1	Gene Expression	Generic Transcription Pathway 0.40 Gene Expression 0.40

1 Reactome Pathway for ZNF273

Generic Transcription Pathway

Gene Ontology (GO): 2 biological process terms:    About this table

Drugs & Compounds
for ZNF273 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for ZNF273 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for ZNF273 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ZNF273 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for ZNF273
		Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ZNF273
		QuantiTect SYBR Green Assays in human, mouse, rat ZNF273
		QuantiFast Probe-based Assays in human, mouse, rat ZNF273

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF273

Orthologs
for ZNF273 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for ZNF273 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for ZNF273 gene

ZNF85²  ZNF486²  ZNF195²  ZNF92²  ZNF100²  ZNF732²  ZNF675²  ZNF138²  

ZNF506²  ZNF66²  ZNF695²  ZNF626²  ZNF680²  ZNF479²  ZNF253²  ZNF93²  

ZNF682²  ZNF492²  ZNF676²  ZNF681²  ZNF141²  ZNF736²  ZNF679²  ZNF257²  

ZNF254²  ZNF737²  ZNF724P²  ZNF98²  ZNF716²  ZNF714²  ZNF429²  ZNF519²  

ZNF430²  ZNF730²  ZNF708²  ZNF117²  ZNF431²  ZNF90²  ZNF726²  ZNF728²  

Selected SIMAP similar genes for ZNF273 using alignment to 4 protein entries:     ZN273_HUMAN (see all proteins) (see all similar genes):

MGC12518    ZNF257    ZNF724P    ZNF98    ZNF430    ZNF506

ZNF100    ZNF429    ZNF738    ZFS-4    ZNF90    ZNF680

ZNF492    ZNF729    ZNF66    ZNF43    ZNF737    ZNF254

Find genes that share paralogs with ZNF273           About GenesLikeMe


Selected Pseudogenes.org Pseudogenes for ZNF273 (see all 13)
PGOHUM00000242763 PGOHUM00000239813 PGOHUM00000258059 PGOHUM00000246386 PGOHUM00000240248

Genomic Variants
for ZNF273 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ZNF273 (see all 713)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs102638761,2	C,F,A,H	--	64361812(+)	GAGTTC/AAGCCT	2	--	us2k1		25		NS EA NA WA CSA	2478
rs1448921631,2		--	64361894(+)	AATGAA/GTCCTT	2	--	us2k1		0	--	--	--	--
rs102640261,2	C,F	--	64361941(+)	CAGGTC/AGTGAT	2	--	us2k1		10		NA WA CSA EA	371
rs768971011,2	C,F	--	64362005(+)	AGTGAG/AACCCT	2	--	us2k1		1		WA	118
rs102825991,2	C,F	--	64362012(+)	CCCTCT/ATTTCT	2	--	us2k1 trp3		8		WA NA CSA EA	368
rs1911870051,2		--	64362100(+)	GAGGCA/GGGCGG	2	--	us2k1		0	--	--	--	--
rs1479631451,2		--	64362109(+)	GGATCA/CCATGA	2	--	us2k1		0	--	--	--	--
rs1857287481,2		--	64362130(+)	TCGAGA/TCCAGC	2	--	us2k1		0	--	--	--	--
rs1905881881,2		--	64362167(+)	CTACTA/GAAAAT	2	--	us2k1		0	--	--	--	--
rs19661401,2	C,F,A	--	64362191(-)	GCCATC/TGTGCC	2	--	us2k1		8		NA CSA WA EA	368

HapMap Linkage Disequilibrium report for ZNF273 (64330550 - 64391955 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10 variations for ZNF273:    About this table    

Variant ID	Type	Subtype	PubMed ID
dgv1147e201	CNV	Deletion	23290073
esv2677316	CNV	Deletion	23128226
esv2734581	CNV	Deletion	23290073
esv2422405	CNV	Duplication	17116639
nsv510085	CNV	Loss	20534489
nsv508457	CNV	Loss	20534489
dgv226e55	CNV	Loss	17911159
dgv7308n71	CNV	Gain	21882294
dgv7309n71	CNV	Gain	21882294
nsv464518	CNV	Gain	19166990

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing ZNF273

DNA2.0 Custom Variant and Variant Library Synthesis for ZNF273

Disorders / Diseases
for ZNF273 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for ZNF273 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937. (PubMed id 7865130)^{1, 2, 3} Abrink M.... Hellman L. (DNA Cell Biol. 1995)
2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
4. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (amp 2012)
5. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)¹ Wang J....Yang X. (Mol. Syst. Biol. 2011)
6. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (amp 2011)
7. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)¹ Ravasi T....Hayashizaki Y. (Cell 2010)
8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (Genome Res. 2006)
9. The DNA sequence of human chromosome 7. (PubMed id 12853948)² Hillier L.W.... Wilson R.K. (Nature 2003)
10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

External Searches for ZNF273 gene

Genome Databases showing ZNF273 gene

Other Databases showing ZNF273 gene

Specialized Databases showing ZNF273 gene

Products
for ZNF273 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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