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ZNF271 Gene

pseudogene   GIFtS: 40
GCID: GC18P032871

Zinc Finger Protein 271

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Zinc Finger Protein 2711 2     EBV-Induced Zinc Finger Protein3
ZNFEB2 3 5     Epstein-Barr Virus-Induced Zinc Finger Protein3
HZF72     Zinc Finger Protein Dp3
CT-ZFP483     Zinc Finger Protein HZF73
ZNF-EB3     Zinc Finger Protein ZNFphex1333
ZNF-dp3     

External Ids:    HGNC: 130651   Entrez Gene: 107782   Ensembl: ENSG000002572677   OMIM: 6047545   UniProtKB: Q145913   
ORGUL members:         

Export aliases for ZNF271 gene to outside databases

Previous GC identifers: GC18P032904 GC18P032689 GC18P031123 GC18P031124 GC18P029729


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ZNF271 Gene:
Zinc finger proteins interact with nucleic acids and have diverse functions. The zinc finger domain is a conserved
amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines that are involved in
coordinating zinc. Kruppel-related proteins form 1 family of zinc finger proteins. See ZFP93 (MIM 604749) for
additional information on zinc finger proteins.(supplied by OMIM, Apr 2004)

GeneCards Summary for ZNF271 Gene:
ZNF271 (zinc finger protein 271) is a pseudogene, and is affiliated with the lncRNA class.

UniProtKB/Swiss-Prot: ZN271_HUMAN, Q14591
Function: May be involved in transcriptional regulation. Plays a role in the EBV-mediated transformation process




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000018.9  NC_018929.2  NT_010966.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF271 gene promoter:
         POU2F1   POU2F1b   POU2F1a   POU2F1c   Pax-4a   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF271 promoter sequence
   Search Chromatin IP Primers for ZNF271

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF271


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q12   Ensembl cytogenetic band:  18q12.2   HGNC cytogenetic band: 18q12.2

ZNF271 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF271 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P032871:  view genomic region     (about GC identifiers)

Start:
32,870,236 bp from pter      End:
32,890,730 bp from pter
Size:
20,495 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZN271_HUMAN, Q14591 (See protein sequence)
Recommended Name: Zinc finger protein 271  
Size: 655 amino acids; 75535 Da
Sequence caution: Sequence=AAK52068.1; Type=Frameshift; Positions=481;
Secondary accessions: B3KN34 Q96T29 Q9BSX2 Q9UN33 Q9Y5B7
Alternative splicing: 2 isoforms:  Q14591-1   Q14591-2   

Explore the universe of human proteins at neXtProt for ZNF271: NX_Q14591

Explore proteomics data for ZNF271 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF271 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q14591

    ProtoNet protein and cluster: Q14591

    1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: ZN271_HUMAN, Q14591
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 19 C2H2-type zinc fingers


    Find genes that share domains with ZNF271           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN271_HUMAN, Q14591
    Function: May be involved in transcriptional regulation. Plays a role in the EBV-mediated transformation process
    Induction: By Epstein-Barr virus (EBV)

    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF271:

     Increased gamma-H2AX phosphory 

    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN271_HUMAN, Q14591: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    mitochondrion1
    peroxisome1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF271
    Interactions:

        Search GeneGlobe Interaction Network for ZNF271

    1 Interacting protein for ZNF271 (Q145912) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    --Q9WMX22MINT-7046848
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF271 (ZN271)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF271 gene: 
    NM_006629.4  

    Unigene Cluster for ZNF271:

    Zinc finger protein 271
    Hs.314246  [show with all ESTs]
    Unigene Representative Sequence: NR_024565
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000399070(uc002kyq.4 uc002kyp.4 uc002kyr.4) ENST00000465539
    ENST00000540308
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    Additional mRNA sequence: 

    AF159567.1 AK023456.1 BC004510.2 BC017710.1 NR_024565.1 NR_024566.1 X78930.1 

    10 DOTS entries:

    DT.100745242  DT.100745243  DT.211237  DT.308394  DT.95148423  DT.99927883  DT.100711296  DT.102830817 
    DT.100773958  DT.99936362 

    Selected AceView cDNA sequences (see all 94):

    CA447662 BC017710 F07427 Z39393 AI370593 AA464946 CB128123 BC004510 
    BX118808 AA383181 AU155847 BM808701 AA833516 AA992881 AF159567 BV202458 
    AA206766 NM_006629 BU674866 AK023456 F03658 AW090062 Z43315 BU622521 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF271 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGATGAGTGT
    ZNF271 Expression
    About this image

    ZNF271 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF271 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.314246

    UniProtKB/Swiss-Prot: ZN271_HUMAN, Q14591
    Tissue specificity: Expressed in T-cell lines, thymocytes, thyroid and pancreatic islet cells

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF271 gene from Selected species (see all 2)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX763356.12   -- 68.93(n)    BX763356.1 


    ENSEMBL Gene Tree for ZNF271 (if available)
    TreeFam Gene Tree for ZNF271 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF271 gene
    Selected SIMAP similar genes for ZNF271 using alignment to 1 protein entry:     ZN271_HUMAN(see all similar genes):
    ZNF78L1    DKFZp666C237    ZKSCAN1    ZNF818P    kr-znf3    ZNF24
    ZNF436    ZFP3    ZFS-4    ZNF19    ZNF383    ZNF852
    HZF30    HZF36    ZFP41    ZFP92    ZFS-5    ZNF146

    Find genes that share paralogs with ZNF271           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF271 (see all 368)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2019447071,2
    C--32872439(+) CCAAG-/AAAAAA 2 -- int10--------
    rs1115493151,2
    C--32872557(+) TCAACA/GTTTTT 2 -- int12Minor allele frequency- G:0.33CSA 3
    rs560493301,2
    C,F--32872630(+) TTGCGC/TTGTTT 2 -- int15Minor allele frequency- T:0.20NA WA EA 362
    rs1509669001,2
    --32872671(+) TCTCAC/GTCTAG 2 -- int10--------
    rs1894798891,2
    --32872876(+) CTTAGA/GATATG 2 -- int10--------
    rs595227431,2
    C,F--32872882(+) ATATGT/AATAAA 2 -- int11Minor allele frequency- A:0.20EA 120
    rs1407858571,2
    --32872901(+) TTATTA/GTAGAG 2 -- int10--------
    rs1818603601,2
    --32872988(+) CCTCTA/GGAAAT 2 -- int10--------
    rs1859754081,2
    --32873170(+) CAGTGA/GGCTGA 2 -- int10--------
    rs1144349121,2
    F--32873244(+) ATGCTC/TATTAT 2 -- int11Minor allele frequency- T:0.02WA 118

    HapMap Linkage Disequilibrium report for ZNF271 (32870236 - 32890730 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ZNF271: --
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing ZNF271
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF271

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604754    OMIM disorders: --


    Find genes that share disorders with ZNF271           About GenesLikeMe


    Export disorders for ZNF271 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF271 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF271)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sustained expression of the novel EBV-induced zinc finger gene, ZNF- EB, is critical for the transition of B lymphocyte activation to oncogenic growth transformation. (PubMed id 11777961)1, 2, 3, 9 Tune C.E.... Dosch H.-M. (J. Immunol. 2002)
    2. Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937. (PubMed id 7865130)1, 2, 3 Abrink M.... Hellman L. (DNA Cell Biol. 1995)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    7. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10778 HGNC: 13065 AceView: ZNF271 Ensembl:ENSG00000257267 euGenes: HUgn10778
    ECgene: ZNF271 H-InvDB: ZNF271

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF271 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ZNF271 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF271 gene:
    Search GeneIP for patents involving ZNF271

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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