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ZNF268 Gene

protein-coding   GIFtS: 51
GCID: GC12P133757

Zinc Finger Protein 268

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 2681 2
Zinc Finger Protein HZF32 3
HZF32
Zinc Finger Protein 32

External Ids:    HGNC: 130611   Entrez Gene: 107952   Ensembl: ENSG000000906127   OMIM: 6047535   UniProtKB: Q145873   

Export aliases for ZNF268 gene to outside databases

Previous GC identifers: GC12P131279 GC12P133360 GC12P131996 GC12P132368 GC12P133707


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF268 Gene:
ZNF268 (zinc finger protein 268) is a protein-coding gene. Diseases associated with ZNF268 include human t-cell leukemia virus type 1, and t-cell leukemia. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZNF616.

UniProtKB/Swiss-Prot: ZN268_HUMAN, Q14587
Function: Isoform 1: Acts as a transcriptional repressor. Inhibits erythroid differentiation and tumor cell
proliferation. Plays a role during ovarian cancer development and progression
Function: Isoform 2: Contributes to cervical carcinogenesis in part through the TNF-alpha-induced NF-kappa-B
signaling pathway by interacting with the I-kappa-B-kinase (IKK) core complex

Gene Wiki entry for ZNF268 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NC_018923.2  NT_024477.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF268 gene promoter:
         CREB   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF268 promoter sequence
   Search Chromatin IP Primers for ZNF268

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF268


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.33   Ensembl cytogenetic band:  12q24.33   HGNC cytogenetic band: 12q24.33

ZNF268 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF268 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P133757:  view genomic region     (about GC identifiers)

Start:
133,707,570 bp from pter      End:
133,783,698 bp from pter
Size:
76,129 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ZN268_HUMAN, Q14587 (See protein sequence)
Recommended Name: Zinc finger protein 268  
Size: 947 amino acids; 108374 Da
Subunit: Interacts (via the KRAB domain) with TRIM28 (via the RBCC domain); the interaction increases ZNF268
nuclear localization activity. Isoform 2 interacts with CHUK and IKBKB; the interaction is further increased in a
TNF-alpha-dependent manner
Developmental stage: Expressed in fetal liver from 5 weeks until 4 months but drastically reduced by 6 months and
became non-detectible by 7 months. Expressed in hematopoietic stem cells in 3 weeks and 5 weeks (at protein
level). Expressed in fetal liver
Selected PDB 3D structures from and Proteopedia for ZNF268 (see all 23):
2EL4 (3D)        2EL5 (3D)        2EL6 (3D)        2EM1 (3D)        2EMV (3D)        2EMW (3D)    
Secondary accessions: Q8TDG8 Q96RH4 Q9BZJ9
Alternative splicing: 7 isoforms:  Q14587-1   Q14587-2   Q14587-3   Q14587-4   Q14587-6   Q14587-7   Q14587-8   

Explore the universe of human proteins at neXtProt for ZNF268: NX_Q14587

Explore proteomics data for ZNF268 at MOPED


See ZNF268 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (9 alternative transcripts): 
NP_001159353.1  NP_001159354.1  NP_001159355.1  NP_001159356.2  NP_001159357.1  NP_001159358.1  NP_001159359.1  NP_003406.1  
NP_694422.2  

ENSEMBL proteins: 
 ENSP00000444412   ENSP00000228289   ENSP00000437410   ENSP00000442446   ENSP00000466629  
 ENSP00000467781   ENSP00000437858   ENSP00000438941   ENSP00000443721   ENSP00000446153  
 ENSP00000439539   ENSP00000467922   ENSP00000466622   ENSP00000464721   ENSP00000409295  
 ENSP00000445713  
Reactome Protein details: Q14587

ZNF268 Human Recombinant Protein Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
ZNF: Zinc fingers, C2H2-type

4 InterPro protein domains:
 IPR001909 Krueppel-associated_box
 IPR015880 Znf_C2H2-like
 IPR013087 Znf_C2H2/integrase_DNA-bd
 IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q14587

ProtoNet protein and cluster: Q14587

2 Blocks protein domains:
IPB001909 KRAB box
IPB007086 C2H2-type zinc finger signature


UniProtKB/Swiss-Prot: ZN268_HUMAN, Q14587
Domain: The KRAB domain functions to reinforce the nuclear localization of isoform 1 in addition to its
transcription repression activity
Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
Similarity: Contains 24 C2H2-type zinc fingers
Similarity: Contains 1 KRAB domain


ZNF268 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: ZN268_HUMAN, Q14587
Function: Isoform 1: Acts as a transcriptional repressor. Inhibits erythroid differentiation and tumor cell
proliferation. Plays a role during ovarian cancer development and progression
Function: Isoform 2: Contributes to cervical carcinogenesis in part through the TNF-alpha-induced NF-kappa-B
signaling pathway by interacting with the I-kappa-B-kinase (IKK) core complex
Induction: Down-regulated during erythroid differentiation by GATA1. Down-regulated by HTLV-1 Tax through the
CREB/ATF pathway. Up-regulated by the regulator of nonsense transcript UPF1. Up-regulated by the cyclic
AMP-dependent transcription factor ATF4

     Gene Ontology (GO): 5 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003676nucleic acid binding ----
GO:0003677DNA binding NAS11311945
GO:0003700sequence-specific DNA binding transcription factor activity NAS11311945
GO:0005515protein binding IPI--
GO:0046872metal ion binding IEA--
     
ZNF268 for ontologies           About GeneDecksing


Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
ZN268_HUMAN, Q14587: Isoform 1: Nucleus
ZN268_HUMAN, Q14587: Isoform 2: Nucleus. Cytoplasm

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005622intracellular ----
GO:0005634nucleus NAS11311945
GO:0005737cytoplasm IDA15547661

ZNF268 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for ZNF268 About    
See pathways by source

SuperPathContained pathways About
1Gene Expression
Generic Transcription Pathway0.40
Gene Expression0.40

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 Reactome Pathway for ZNF268
    Generic Transcription Pathway



ZNF268 for pathways           About GeneDecksing

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF268
Interactions:

    Search GeneGlobe Interaction Network for ZNF268

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

4 Interacting proteins for ZNF268 (ENSP000002282894) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
TRIM28ENSP000002530244STRING: ENSP00000253024
TRIM24ENSP000003405074STRING: ENSP00000340507
CBX3ENSP000003366874STRING: ENSP00000336687
NDEL1ENSP000003339824STRING: ENSP00000333982
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Gene Ontology (GO): Selected biological process terms (see all 21):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA12822888
GO:0001934positive regulation of protein phosphorylation IDA--
GO:0006351transcription, DNA-templated IEA--
GO:0006355regulation of transcription, DNA-templated NAS11311945
GO:0007346regulation of mitotic cell cycle IMP--

ZNF268 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for ZNF268 (ZN268)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for ZNF268 gene (9 alternative transcripts): 
NM_001165881.2  NM_001165882.2  NM_001165883.1  NM_001165884.2  NM_001165885.1  NM_001165886.1  NM_001165887.1  NM_003415.2  
NM_152943.2  

Unigene Cluster for ZNF268:

Zinc finger protein 268
Hs.124047  [show with all ESTs]
Unigene Representative Sequence: NM_152943
Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
ENST00000536435(uc010tcf.2 uc010tcb.2 uc010tbw.2 uc010tch.2 uc021rgu.1)
ENST00000228289(uc010tbv.1) ENST00000537973 ENST00000546126 ENST00000541211
ENST00000500625 ENST00000539248 ENST00000542711(uc010tbx.2 uc010tce.2)
ENST00000536899 ENST00000542986(uc010tcc.1 uc010tcg.2 uc010tca.2)
ENST00000541975 ENST00000541009(uc010tbz.1 uc010tcd.1) ENST00000592241
ENST00000588312 ENST00000585488 ENST00000591951 ENST00000534953 ENST00000416488

miRNA
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Inhib. RNA
Products:
     
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Predesigned siRNA for gene silencing in human, mouse, rat ZNF268
Clone
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Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ZNF268
  QuantiTect SYBR Green Assays in human, mouse, rat ZNF268
  QuantiFast Probe-based Assays in human, mouse, rat ZNF268

Additional mRNA sequence: 

AF141655.1 AF317549.1 AF385187.1 AF432217.1 AK027712.1 AY583691.1 BC058548.1 BC110542.2 
DQ057356.1 DQ057357.1 DQ057358.1 DQ057359.1 DQ057360.1 DQ057361.1 X78926.1 

20 DOTS entries:

DT.102833283  DT.95366248  DT.97783973  DT.99961031  DT.95367086  DT.97817707  DT.432396  DT.100752176 
DT.120763765  DT.121214054  DT.310160  DT.121214044  DT.97826620  DT.121214006  DT.121214095  DT.121214183 
DT.121644746  DT.97807608  DT.100734563  DT.40298778 

Selected AceView cDNA sequences (see all 30):

BP336914 BC058548 CA430853 BQ006014 BM833018 AF141655 AI188398 BQ013165 
BQ218614 AV714355 BM043563 BP382964 CD643737 CD370657 AL598141 N55883 
BQ010644 AA081606 AI588087 BP358555 NM_003415 AF385187 BG912907 CD617089 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZNF268 (see all 9)    About this scheme

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b
SP1:                                                  -                                   -           -     -               
SP2:                                      -           -     -                                                               
SP3:                    -     -     -     -           -                                   -                                 
SP4:                                -     -           -                                                                     
SP5:                                      -           -                                                                     


ECgene alternative splicing isoforms for ZNF268

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ZNF268 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CTATGAGGGA
ZNF268 Expression
About this image

ZNF268 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

ZNF268 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.124047

UniProtKB/Swiss-Prot: ZN268_HUMAN, Q14587
Tissue specificity: Overexpressed in ovarian cancer tissues compared to normal ovarian tissues. Isoform 1 and
isoform 2 are expressed in squamous epithelium tissues. Isoform 2 is overexpressed in squamous cervical cancer
(at protein level). Expressed in blood cells. Isoform 1 is expressed in pancreas, lung, skeletal muscle, heart,
placenta, liver, kidney and brain. Isoform 2 expressed in chronic lymphocytic leukemia (CLL) and several tumor
cell lines. Isoform 3 is expressed in several tumor cells. Isoform 5 is expressed in fetal liver and several
tumor cells. Isoform 6 is weakly expressed in brain, lung amd small intestin and in several tumor cells. Isoform
7 is expressed in fetal liver and several tumor cells

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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF268

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and mouse.

Orthologs for ZNF268 gene from Selected species (see all 6)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia LOC1026363831 zinc finger protein 658-like 61.96(n)
56.47(a)
  102636383  XM_006514424.1  XP_006514487.1 


ENSEMBL Gene Tree for ZNF268 (if available)
TreeFam Gene Tree for ZNF268 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for ZNF268 gene
ZNF6162  ZNF4732  ZNF1602  ZNF4932  ZNF5462  ZNF992  ZNF8362  ZNF7212  
ZNF5942  ZFP622  ZNF8412  ZNF432  ZNF780B2  ZNF1972  ZNF1072  ZNF585A2  
ZNF8082  ZNF3472  ZNF8452  ZNF585B2  ZNF6582  ZNF6292  ZNF6242  ZNF8142  
Selected SIMAP similar genes for ZNF268 using alignment to 12 protein entries:     ZN268_HUMAN (see all proteins) (see all similar genes):
kr-znf3    ZNF84    ZNF525    ZNF649    SPATS2    ZNF78L1
ZNF10    ZNF350    ZNF83    ZNF569    ZNF22    ZNF32
ZNF320    DKFZp666M039    DKFZp686N14223    HZF36    ZFP1    ZNF624

ZNF268 for paralogs           About GeneDecksing


3 Pseudogenes.org Pseudogenes for ZNF268
PGOHUM00000247877 PGOHUM00000234387 PGOHUM00000260298


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ZNF268 (see all 642)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 12 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1857897661,2
--130562906(+) CCCCTC/TTCTAC 9 -- ds50010--------
rs1868975541,2
--133756185(+) GAGGCA/GGAGCT 9 -- us2k10--------
rs1900941491,2
--133756292(+) GCCGAA/GCTCGG 9 -- us2k10--------
rs1823770571,2
--133756410(+) AAAAAC/TACAAA 9 -- us2k10--------
rs1439188481,2
--133756503(+) GGTTGC/TGGTGA 9 -- us2k10--------
rs1467795811,2
--133756518(+) AGATCG/TGGCCA 9 -- us2k10--------
rs44699311,2
C,F,A,H--133756780(+) atataT/Aaaaaa 9 -- us2k18Minor allele frequency- A:0.29NA WA EA 502
rs1865565851,2
C--133756920(+) ATAAGA/GAAGAA 9 -- us2k10--------
rs1391400541,2
C--133757056(+) GATGT-/AGAGTGT 9 -- us2k10--------
rs1405432411,2
C--133757117(+) AATCAC/TAAATT 9 -- us2k10--------

HapMap Linkage Disequilibrium report for ZNF268 (133707570 - 133783698 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for ZNF268 (see all 11):    About this table    
Variant IDTypeSubtypePubMed ID
esv3249CNV Deletion18987735
esv2675589CNV Deletion23128226
nsv470337CNV Loss18288195
nsv455818CNV Loss19166990
nsv518970CNV Gain19592680
dgv220n27CNV Gain19166990
nsv899836CNV Gain21882294
nsv826570CNV Gain20364138
esv27162CNV Gain+Loss19812545
nsv442301CNV CNV18776908

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 604753    OMIM disorders: --

5 diseases for ZNF268:    
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human t-cell leukemia virus type 1    t-cell leukemia    cervical cancer    cervicitis
leukemia


ZNF268 for disorders           About GeneDecksing

Genetic Association Database (GAD): ZNF268

Export disorders for ZNF268 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for ZNF268 gene, integrated from 10 sources (see all 21):
(articles sorted by number of sources associating them with ZNF268)
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world of online information

  1. Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937. (PubMed id 7865130)1, 2, 3 Abrink M.... Hellman L. (DNA Cell Biol. 1995)
  2. A splice variant of the C(2)H(2)-type zinc finger protein, ZNF268s, regulates NF-kappaB activation by TNF-alpha. (PubMed id 18677094)1, 2, 9 Chun J.N....Kang S.W. (Mol. Cells 2008)
  3. Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1. (PubMed id 23665872)1, 2 Wang W....Huang Z. (Cell. Mol. Life Sci. 2013)
  4. Knockdown of ZNF268, which is transcriptionally downregulated by GATA-1, promotes proliferation of K562 cells. (PubMed id 22235304)1, 2 Zeng Y....Li W. (PLoS ONE 2012)
  5. The zinc finger protein ZNF268 is overexpressed in human cervical cancer and contributes to tumorigenesis via enhancing NF-I_B signaling. (PubMed id 23091055)1, 2 Wang W....Huang Z. (J. Biol. Chem. 2012)
  6. Human T-cell leukemia virus type 1 oncoprotein tax represses ZNF268 expression through the cAMP-responsive element-binding protein/activating transcription factor pathway. (PubMed id 18375384)1, 2 Wang D....Li W.X. (J. Biol. Chem. 2008)
  7. The mammalian gene ZNF268 is regulated by hUpf1. (PubMed id 18774934)1, 2 Zhu C....Li W. (Biochemistry Mosc. 2008)
  8. Aberrant alternative splicing of human zinc finger gene ZNF268 in human hematological malignancy. (PubMed id 18949428)1, 2 Zhao Z....Li W. (Oncol. Rep. 2008)
  9. KRAB-containing zinc finger gene ZNF268 encodes multiple alternatively spliced isoforms that contain transcription regulatory domains. (PubMed id 16865230)1, 2 Shao H....Li W. (Int. J. Mol. Med. 2006)
  10. Transcription of human zinc finger ZNF268 gene requires an intragenic promoter element. (PubMed id 16787922)1, 2 Guo M.X....Li W.X. (J. Biol. Chem. 2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
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  Query String
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OMIM
NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 10795 HGNC: 13061 AceView: ZNF268 Ensembl:ENSG00000090612 euGenes: HUgn10795
ECgene: ZNF268 H-InvDB: ZNF268

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ZNF268 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ZNF268 gene:
Search GeneIP for patents involving ZNF268

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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