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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF268 Gene

protein-coding   GIFtS: 52
GCID: GC12P133757

zinc finger protein 268

 Explore 3 diseases affiliated with
ZNF268 via our new
 Human Malady Compendium 
Biological research products
for ZNF268
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Zinc Finger Protein 2681 2
HZF31 2
Zinc Finger Protein HZF32 3
Zinc Finger Protein 32

External Ids:    HGNC: 130611   Entrez Gene: 107952   Ensembl: ENSG000000906127   OMIM: 6047535   UniProtKB: Q145873   

Export aliases for ZNF268 gene to outside databases

Previous GC identifers: GC12P131279 GC12P133360 GC12P131996 GC12P132368 GC12P133707


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZN268_HUMAN, Q14587
Function: May be involved in transcriptional regulation

Gene Wiki entry for ZNF268


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_024477.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF268 gene promoter:
         CREB   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF268 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF268

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF268


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.33   Ensembl cytogenetic band:  12q24.33   HGNC cytogenetic band: 12q24.33

ZNF268 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF268 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P133757:  view genomic region     (about GC identifiers)

Start:
133,707,570 bp from pter      End:
133,783,698 bp from pter
Size:
76,129 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZN268_HUMAN, Q14587 (See protein sequence)
Recommended Name: Zinc finger protein 268  
Size: 947 amino acids; 108374 Da
Subcellular location: Nucleus (Probable)
Developmental stage: Highly expressed in 3- to 5-week-old embryos
6/23 PDB 3D structures from and Proteopedia for ZNF268 (see all 23):
2EL4 (3D)        2EL5 (3D)        2EL6 (3D)        2EM1 (3D)        2EMV (3D)        2EMW (3D)    
Secondary accessions: Q96RH4 Q9BZJ9
Alternative splicing: 2 isoforms:  Q14587-1   Q14587-2   

Explore the universe of human proteins at neXtProt for ZNF268: NX_Q14587

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q14587

  • ZNF268 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (9 alternative transcripts): 
    NP_001159353.1  NP_001159354.1  NP_001159355.1  NP_001159356.2  NP_001159357.1  NP_001159358.1  NP_001159359.1  NP_003406.1  
    NP_694422.2  

    ENSEMBL proteins: 
     ENSP00000444412   ENSP00000228289   ENSP00000437410   ENSP00000442446   ENSP00000466629  
     ENSP00000467781   ENSP00000437858   ENSP00000438941   ENSP00000443721   ENSP00000446153  
     ENSP00000439539   ENSP00000467922   ENSP00000466622   ENSP00000464721   ENSP00000409295  
     ENSP00000445713  
    Reactome Protein details: Q14587
    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: ZNF268
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    Novus Biologicals ZNF268 Protein
    Novus Biologicals ZNF268 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ZNF268

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus NAS11311945


    ZNF268 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for ZNF268


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ZNF268 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q14587

    ProtoNet protein and cluster: Q14587

    2 Blocks protein families:
    IPB001909 KRAB box
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZN268_HUMAN, Q14587
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 24 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ZN268_HUMAN, Q14587
    Function: May be involved in transcriptional regulation

    miRNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF268

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding NAS11311945
    GO:0003700sequence-specific DNA binding transcription factor activity NAS11311945
    GO:0008270zinc ion binding IEA--


    ZNF268 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Generic Transcription Pathway
    Generic Transcription Pathway1.00
    Gene Expression0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2        Reactome Pathways for ZNF268
        Generic Transcription Pathway
    Gene Expression



    ZNF268 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF268

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for ZNF268 (ENSP000002282894) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRIM28ENSP000002530244STRING: ENSP00000253024
    TRIM24ENSP000003405074STRING: ENSP00000340507
    CBX3ENSP000003366874STRING: ENSP00000336687
    NDEL1ENSP000003339824STRING: ENSP00000333982
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent NAS11311945


    ZNF268 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF268
    Search CenterWatch for drugs/clinical trials and news about ZNF268 / ZN268 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF268 gene (9 alternative transcripts): 
    NM_001165881.2  NM_001165882.2  NM_001165883.1  NM_001165884.2  NM_001165885.1  NM_001165886.1  NM_001165887.1  NM_003415.2  
    NM_152943.2  

    Unigene Cluster for ZNF268:

    Zinc finger protein 268
    Hs.124047  [show with all ESTs]
    Unigene Representative Sequence: NM_152943
    18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000536435(uc010tcf.2 uc010tcb.2 uc010tbw.2 uc010tch.2 uc021rgu.1)
    ENST00000228289(uc010tbv.1) ENST00000537973 ENST00000546126 ENST00000541211
    ENST00000500625 ENST00000539248 ENST00000542711(uc010tbx.2 uc010tce.2)
    ENST00000536899 ENST00000542986(uc010tcc.1 uc010tcg.2 uc010tca.2)
    ENST00000541975 ENST00000541009(uc010tbz.1 uc010tcd.1) ENST00000592241
    ENST00000588312 ENST00000585488 ENST00000591951 ENST00000534953 ENST00000416488


    miRNA
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    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    Additional cDNA sequence: 

    AF141655.1 AF317549.1 AF385187.1 AF432217.1 AK027712.1 AY583691.1 BC058548.1 BC110542.2 
    DQ057356.1 DQ057357.1 DQ057358.1 DQ057359.1 DQ057360.1 DQ057361.1 X78926.1 

    20 DOTS entries:

    DT.102833283  DT.95366248  DT.97783973  DT.99961031  DT.95367086  DT.97817707  DT.432396  DT.100752176 
    DT.120763765  DT.121214054  DT.310160  DT.121214044  DT.97826620  DT.121214006  DT.121214095  DT.121214183 
    DT.121644746  DT.97807608  DT.100734563  DT.40298778 

    24/30 AceView cDNA sequences (see all 30):

    BM833018 CA430853 AF141655 BQ006014 BP336914 BC058548 CD370657 AI188398 
    AV714355 BQ013165 BM043563 BP382964 BQ218614 N55883 AL598141 CD643737 
    BQ010644 AA081606 BP358555 AI588087 CD617089 NM_152943 AF317549 AF385187 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF268 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b
    SP1:                                                  -                                   -           -     -               
    SP2:                                      -           -     -                                                               
    SP3:                    -     -     -     -           -                                   -                                 
    SP4:                                -     -           -                                                                     
    SP5:                                      -           -                                                                     


    ECgene alternative splicing isoforms for ZNF268

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF268 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTATGAGGGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See ZNF268 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF268

    SOURCE GeneReport for Unigene cluster: Hs.124047
        SABiosciences Custom PCR Arrays for ZNF268
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF268

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF268 gene from 1/5 species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    35(a)
    1 → many
    GL343557.1(371826-420180)


    ENSEMBL Gene Tree for ZNF268 (if available)
    TreeFam Gene Tree for ZNF268 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF268 gene
    ZNF1752  ZNF6742  LOC1002875152  ZNF6142  ZNF4322  ZNF6132  ZNF262  ZNF3502  
    ZNF812  ZNF6492  ZNF6052  ZNF5772  ZNF842  ZNF6302  ZFP372  ZNF4842  
    ENSG000002296312  ZNF1822  ZNF412  LOC1009964642  ZNF6152  ZNF3002  
    18/487 SIMAP similar genes for ZNF268 using alignment to 14 protein entries:     ZN268_HUMAN (see all proteins) (see all similar genes):
    kr-znf3    ZNF84    ZNF525    SPATS2    ZNF78L1    ZNF10
    ZNF569    ZNF22    ZNF32    DKFZp666M039    DKFZp686N14223    HZF36
    ZFP1    ZNF624    ZNF81    ZNF283    ZNF852    ZNF420

    ZNF268 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for ZNF268
    PGOHUM00000247877 PGOHUM00000234387 PGOHUM00000260298


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/526 NCBI SNPs in ZNF268 are shown (see all 526    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1868975541,2
    --133756185(+) GAGGCA/GGAGCT 9 -- us2k10--------
    rs1900941491,2
    --133756292(+) GCCGAA/GCTCGG 9 -- us2k10--------
    rs1823770571,2
    --133756410(+) AAAAAC/TACAAA 9 -- us2k10--------
    rs1439188481,2
    --133756503(+) GGTTGC/TGGTGA 9 -- us2k10--------
    rs1467795811,2
    --133756518(+) AGATCG/TGGCCA 9 -- us2k10--------
    rs44699311,2
    C,F,A,H,--133756780(+) ATATAT/AAAAAA 9 -- us2k18Minor allele frequency- A:0.29NA WA EA 502
    rs1865565851,2
    --133756920(+) ATAAGA/GAAGAA 9 -- us2k10--------
    rs1391400541,2
    --133757056(+) GATGT-/AGAGTGT 9 -- us2k10--------
    rs1405432411,2
    --133757117(+) AATCAC/TAAATT 9 -- us2k10--------
    rs779121331,2
    F,--133757217(+) AAAATT/AACACT 9 -- us2k11Minor allele frequency- A:0.02WA 118

    HapMap Linkage Disequilibrium report for ZNF268 (133707570 - 133783698 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 18 variations for ZNF268
         11 CNVs: 66385 86695 29933 76244 76240 37673 76243 53396 86696 29934 66386
         7 Indels: 86697 41665 86698 76242 39952 86699 76241

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF268
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF268

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZNF268 for disorders           About GeneDecksing

    OMIM gene information: 604753    OMIM disorders: --

    3 diseases for ZNF268:    About MalaCards
    human t-cell leukemia virus type 1    t-cell leukemia    leukemia


    Export disorders for ZNF268 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF268 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with ZNF268)
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    1. Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937. (PubMed id 7865130)1, 2, 3 Abrink M.... Hellman L. (1995)
    2. Cloning and characterization of a novel Kruppel-like zinc finger gene, ZNF268, expressed in early human embryo. (PubMed id 11311945)1, 2 Gou D.M.... Li W.X. (2001)
    3. A splice variant of the C(2)H(2)-type zinc finger protein, ZNF268s, regulates NF-kappaB activation by TNF-alpha. (PubMed id 18677094)1, 9 Chun J.N....Kang S.W. (2008)
    4. The zinc finger protein ZNF268 is overexpressed in hum an cervical cancer and contributes to tumorigenesis via enhancing NF-kB signalin g. (PubMed id 23091055)1 Wang W....Huang Z. (2012)
    5. Knockdown of ZNF268, which is transcriptionally downre gulated by GATA-1, promotes proliferation of K562 cells. (PubMed id 22235304)1 Zeng Y....Li W. (2012)
    6. Human T-cell leukemia virus type 1 oncoprotein tax represses ZNF268 expression through the cAMP-responsive element-binding protein/activating transcription factor pathway. (PubMed id 18375384)1 Wang D....Li W.X. (2008)
    7. The mammalian gene ZNF268 is regulated by hUpf1. (PubMed id 18774934)1 Zhu C....Li W. (2008)
    8. Aberrant alternative splicing of human zinc finger gene ZNF268 in human hematological malignancy. (PubMed id 18949428)1 Zhao Z....Li W. (2008)
    9. KRAB-containing zinc finger gene ZNF268 encodes multiple alternatively spliced isoforms that contain transcription regulatory domains. (PubMed id 16865230)1 Shao H....Li W. (2006)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10795 HGNC: 13061 AceView: ZNF268 Ensembl:ENSG00000090612 euGenes: HUgn10795
    ECgene: ZNF268 H-InvDB: ZNF268

    (According to HUGE)
    About This Section
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF268 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF268 gene:
    Search GeneIP for patents involving ZNF268

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