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Aliases for ZNF268 Gene

Aliases for ZNF268 Gene

  • Zinc Finger Protein 268 2 3
  • Zinc Finger Protein HZF3 3 4
  • Zinc Finger Protein 3 3
  • HZF3 3

External Ids for ZNF268 Gene

Previous GeneCards Identifiers for ZNF268 Gene

  • GC12P131279
  • GC12P133360
  • GC12P131996
  • GC12P132368
  • GC12P133707
  • GC12P133757

Summaries for ZNF268 Gene

GeneCards Summary for ZNF268 Gene

ZNF268 (Zinc Finger Protein 268) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZNF808.

UniProtKB/Swiss-Prot for ZNF268 Gene

  • Isoform 1: Acts as a transcriptional repressor. Inhibits erythroid differentiation and tumor cell proliferation. Plays a role during ovarian cancer development and progression

  • Isoform 2: Contributes to cervical carcinogenesis in part through the TNF-alpha-induced NF-kappa-B signaling pathway by interacting with the I-kappa-B-kinase (IKK) core complex

Gene Wiki entry for ZNF268 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF268 Gene

Genomics for ZNF268 Gene

Regulatory Elements for ZNF268 Gene

Transcription factor binding sites by QIAGEN in the ZNF268 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF268 Gene

Start:
133,181,409 bp from pter
End:
133,214,831 bp from pter
Size:
33,423 bases
Orientation:
Plus strand

Genomic View for ZNF268 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF268 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF268 Gene

Proteins for ZNF268 Gene

  • Protein details for ZNF268 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14587-ZN268_HUMAN
    Recommended name:
    Zinc finger protein 268
    Protein Accession:
    Q14587
    Secondary Accessions:
    • Q8TDG8
    • Q96RH4
    • Q9BZJ9

    Protein attributes for ZNF268 Gene

    Size:
    947 amino acids
    Molecular mass:
    108374 Da
    Quaternary structure:
    • Interacts (via the KRAB domain) with TRIM28 (via the RBCC domain); the interaction increases ZNF268 nuclear localization activity. Isoform 2 interacts with CHUK and IKBKB; the interaction is further increased in a TNF-alpha-dependent manner.

    Three dimensional structures from OCA and Proteopedia for ZNF268 Gene

    Alternative splice isoforms for ZNF268 Gene

neXtProt entry for ZNF268 Gene

Proteomics data for ZNF268 Gene at MOPED

Post-translational modifications for ZNF268 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF268 Gene

Domains for ZNF268 Gene

Gene Families for ZNF268 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Suggested Antigen Peptide Sequences for ZNF268 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14587

UniProtKB/Swiss-Prot:

ZN268_HUMAN :
  • Q14587
Domain:
  • The KRAB domain functions to reinforce the nuclear localization of isoform 1 in addition to its transcription repression activity
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 24 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF268: view

Function for ZNF268 Gene

Molecular function for ZNF268 Gene

UniProtKB/Swiss-Prot Function:
Isoform 1: Acts as a transcriptional repressor. Inhibits erythroid differentiation and tumor cell proliferation. Plays a role during ovarian cancer development and progression
UniProtKB/Swiss-Prot Function:
Isoform 2: Contributes to cervical carcinogenesis in part through the TNF-alpha-induced NF-kappa-B signaling pathway by interacting with the I-kappa-B-kinase (IKK) core complex
UniProtKB/Swiss-Prot Induction:
Down-regulated during erythroid differentiation by GATA1. Down-regulated by HTLV-1 Tax through the CREB/ATF pathway. Up-regulated by the regulator of nonsense transcript UPF1. Up-regulated by the cyclic AMP-dependent transcription factor ATF4.

Gene Ontology (GO) - Molecular Function for ZNF268 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding NAS 11311945
GO:0003700 sequence-specific DNA binding transcription factor activity NAS 11311945
GO:0005515 protein binding IPI 23091055
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF268: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF268

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF268 Gene

Localization for ZNF268 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF268 Gene

Isoform 1: Nucleus.
Isoform 2: Nucleus. Cytoplasm.

Gene Ontology (GO) - Cellular Components for ZNF268 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus NAS 11311945
GO:0005737 cytoplasm IDA --
GO:0015629 actin cytoskeleton IDA --
genes like me logo Genes that share ontologies with ZNF268: view

No data available for Subcellular locations from COMPARTMENTS for ZNF268 Gene

Pathways for ZNF268 Gene

SuperPathways for ZNF268 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF268: view

Pathways by source for ZNF268 Gene

2 Reactome pathways for ZNF268 Gene

Interacting Proteins for ZNF268 Gene

Gene Ontology (GO) - Biological Process for ZNF268 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 12822888
GO:0001934 positive regulation of protein phosphorylation IDA 23091055
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 11311945
GO:0007346 regulation of mitotic cell cycle IMP 23946776
genes like me logo Genes that share ontologies with ZNF268: view

Transcripts for ZNF268 Gene

Unigene Clusters for ZNF268 Gene

Zinc finger protein 268:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF268

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF268 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b
SP1: - - - -
SP2: - - -
SP3: - - - - - -
SP4: - - -
SP5: - -
SP6: - - -
SP7: - -
SP8: -
SP9: - - - -

Relevant External Links for ZNF268 Gene

GeneLoc Exon Structure for
ZNF268
ECgene alternative splicing isoforms for
ZNF268

Expression for ZNF268 Gene

mRNA expression in normal human tissues for ZNF268 Gene

Protein differential expression in normal tissues for ZNF268 Gene

This gene is overexpressed in Cerebral cortex (34.4), Placenta (10.5), and Kidney (7.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF268 Gene

SOURCE GeneReport for Unigene cluster for ZNF268 Gene Hs.124047

mRNA Expression by UniProt/SwissProt for ZNF268 Gene

Q14587-ZN268_HUMAN
Tissue specificity: Overexpressed in ovarian cancer tissues compared to normal ovarian tissues. Isoform 1 and isoform 2 are expressed in squamous epithelium tissues. Isoform 2 is overexpressed in squamous cervical cancer (at protein level). Expressed in blood cells. Isoform 1 is expressed in pancreas, lung, skeletal muscle, heart, placenta, liver, kidney and brain. Isoform 2 expressed in chronic lymphocytic leukemia (CLL) and several tumor cell lines. Isoform 3 is expressed in several tumor cells. Isoform 5 is expressed in fetal liver and several tumor cells. Isoform 6 is weakly expressed in brain, lung amd small intestin and in several tumor cells. Isoform 7 is expressed in fetal liver and several tumor cells.
genes like me logo Genes that share expressions with ZNF268: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Expression partners for ZNF268 Gene

Orthologs for ZNF268 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF268 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia ZNF268 35
  • 86.37 (n)
  • 84.63 (a)
ZNF268 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia LOC102636383 35
  • 61.96 (n)
  • 56.47 (a)
Zfp658 36
  • 41 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia ZNF268 35
  • 99.26 (n)
  • 98.63 (a)
ZNF268 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF268 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 47 (a)
ManyToMany
-- 36
  • 50 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
-- 36
  • 50 (a)
ManyToMany
-- 36
  • 49 (a)
ManyToMany
-- 36
  • 49 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 47 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
CSA.1668 36
  • 32 (a)
ManyToMany
Species with no ortholog for ZNF268:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF268 Gene

ENSEMBL:
Gene Tree for ZNF268 (if available)
TreeFam:
Gene Tree for ZNF268 (if available)

Paralogs for ZNF268 Gene

Pseudogenes.org Pseudogenes for ZNF268 Gene

genes like me logo Genes that share paralogs with ZNF268: view

Variants for ZNF268 Gene

Sequence variations from dbSNP and Humsavar for ZNF268 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs4031 -- 133,205,019(-) TCCCT(C/T)ATAGC utr-variant-3-prime
rs1134645 -- 133,205,940(+) GTTCT(A/G)TGGTA utr-variant-3-prime
rs1134646 -- 133,206,012(+) CATTT(G/T)CTTAA utr-variant-3-prime
rs4405357 -- 133,197,240(+) TGTCC(A/G)TGTGT intron-variant
rs4450201 -- 133,198,137(+) tgcct(A/G)ggttt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF268 Gene

Variant ID Type Subtype PubMed ID
nsv899836 CNV Gain 21882294
esv27162 CNV Gain+Loss 19812545
nsv470337 CNV Loss 18288195
nsv518970 CNV Gain 19592680
dgv220n27 CNV Gain 19166990
nsv455818 CNV Loss 19166990
nsv442301 CNV CNV 18776908
nsv826570 CNV Gain 20364138
nsv514654 CNV Complex 21397061
esv3249 CNV Deletion 18987735
esv2675589 CNV Deletion 23128226

Relevant External Links for ZNF268 Gene

HapMap Linkage Disequilibrium report
ZNF268

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF268 Gene

Disorders for ZNF268 Gene

Relevant External Links for ZNF268

Genetic Association Database (GAD)
ZNF268

No disorders were found for ZNF268 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for ZNF268 Gene

Publications for ZNF268 Gene

  1. A splice variant of the C(2)H(2)-type zinc finger protein, ZNF268s, regulates NF-kappaB activation by TNF-alpha. (PMID: 18677094) Chun J.N. … Kang S.W. (Mol. Cells 2008) 3 4 23
  2. Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937. (PMID: 7865130) Abrink M. … Hellman L. (DNA Cell Biol. 1995) 2 3 4
  3. Cloning and characterization of a novel Kruppel-like zinc finger gene, ZNF268, expressed in early human embryo. (PMID: 11311945) Gou D.M. … Li W.X. (Biochim. Biophys. Acta 2001) 3 4
  4. The KRAB domain of zinc finger gene ZNF268: a potential transcriptional repressor. (PMID: 12822888) Sun Y. … Li W.X. (IUBMB Life 2003) 3 4
  5. ZNF268, a novel kruppel-like zinc finger protein, is implicated in early human liver development. (PMID: 15547661) Sun Y. … Li W. (Int. J. Mol. Med. 2004) 3 4

Products for ZNF268 Gene

Sources for ZNF268 Gene

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