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Aliases for ZNF268 Gene

Aliases for ZNF268 Gene

  • Zinc Finger Protein 268 2 3 5
  • Zinc Finger Protein HZF3 3 4
  • Zinc Finger Protein 3 3
  • HZF3 3

External Ids for ZNF268 Gene

Previous GeneCards Identifiers for ZNF268 Gene

  • GC12P131279
  • GC12P133360
  • GC12P131996
  • GC12P132368
  • GC12P133707
  • GC12P133757

Summaries for ZNF268 Gene

GeneCards Summary for ZNF268 Gene

ZNF268 (Zinc Finger Protein 268) is a Protein Coding gene. Diseases associated with ZNF268 include Ovarian Cancer. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF850.

UniProtKB/Swiss-Prot for ZNF268 Gene

  • Isoform 1: Acts as a transcriptional repressor. Inhibits erythroid differentiation and tumor cell proliferation. Plays a role during ovarian cancer development and progression.

  • Isoform 2: Contributes to cervical carcinogenesis in part through the TNF-alpha-induced NF-kappa-B signaling pathway by interacting with the I-kappa-B-kinase (IKK) core complex.

Gene Wiki entry for ZNF268 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF268 Gene

Genomics for ZNF268 Gene

Regulatory Elements for ZNF268 Gene

Enhancers for ZNF268 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F133180 1.1 ENCODE 19.4 +0.2 180 1.5 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 ZNF207 ZNF143 ZNF891 ZNF140 ZNF268 ENSG00000256825 ZNF10 GOLGA3 ZNF84 ENSG00000255919
GH12F133129 1.1 ENCODE 13.3 -51.0 -51014 2.3 PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 CBX5 ZNF891 ZNF10 ZNF84 ZNF605 ZNF140 ZNF268 ENSG00000250790 GOLGA3 DDX51 RPL23AP67
GH12F132954 1 ENCODE 11.1 -225.7 -225673 2.4 ATF1 ARID4B SIN3A DMAP1 ZNF2 YY1 ETS1 GLIS2 CBX5 ZNF143 ZNF84 ZNF891 ENSG00000250790 ZNF140 DDX51 LOC101928597 ENSG00000256825 ZNF10 ZNF268 ZNF26
GH12F132864 0.7 ENCODE 4.5 -315.1 -315091 2.6 TEAD1 HLF CEBPB SIN3A CEBPG EP300 TEAD3 PPARGC1A IRF9 TBX3 ANKLE2 CHFR POLE ENSG00000250790 ZNF268 ENSG00000278949 PIR57259
GH12F132596 0.4 ENCODE 4.1 -585.3 -585250 0.2 ZNF48 LRCOL1 ZNF268 LOC105370094
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF268 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF268 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000092104 492 1799 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 ZNF207 ZNF143

Genomic Location for ZNF268 Gene

Chromosome:
12
Start:
133,181,409 bp from pter
End:
133,214,831 bp from pter
Size:
33,423 bases
Orientation:
Plus strand

Genomic View for ZNF268 Gene

Genes around ZNF268 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF268 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF268 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF268 Gene

Proteins for ZNF268 Gene

  • Protein details for ZNF268 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14587-ZN268_HUMAN
    Recommended name:
    Zinc finger protein 268
    Protein Accession:
    Q14587
    Secondary Accessions:
    • Q8TDG8
    • Q96RH4
    • Q9BZJ9

    Protein attributes for ZNF268 Gene

    Size:
    947 amino acids
    Molecular mass:
    108374 Da
    Quaternary structure:
    • Interacts (via the KRAB domain) with TRIM28 (via the RBCC domain); the interaction increases ZNF268 nuclear localization activity. Isoform 2 interacts with CHUK and IKBKB; the interaction is further increased in a TNF-alpha-dependent manner.

    Three dimensional structures from OCA and Proteopedia for ZNF268 Gene

    Alternative splice isoforms for ZNF268 Gene

neXtProt entry for ZNF268 Gene

Post-translational modifications for ZNF268 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF268 Gene

Domains & Families for ZNF268 Gene

Gene Families for ZNF268 Gene

Suggested Antigen Peptide Sequences for ZNF268 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14587

UniProtKB/Swiss-Prot:

ZN268_HUMAN :
  • The KRAB domain functions to reinforce the nuclear localization of isoform 1 in addition to its transcription repression activity.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 24 C2H2-type zinc fingers.
Domain:
  • The KRAB domain functions to reinforce the nuclear localization of isoform 1 in addition to its transcription repression activity.
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 24 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF268: view

Function for ZNF268 Gene

Molecular function for ZNF268 Gene

UniProtKB/Swiss-Prot Function:
Isoform 1: Acts as a transcriptional repressor. Inhibits erythroid differentiation and tumor cell proliferation. Plays a role during ovarian cancer development and progression.
UniProtKB/Swiss-Prot Function:
Isoform 2: Contributes to cervical carcinogenesis in part through the TNF-alpha-induced NF-kappa-B signaling pathway by interacting with the I-kappa-B-kinase (IKK) core complex.
UniProtKB/Swiss-Prot Induction:
Down-regulated during erythroid differentiation by GATA1. Down-regulated by HTLV-1 Tax through the CREB/ATF pathway. Up-regulated by the regulator of nonsense transcript UPF1. Up-regulated by the cyclic AMP-dependent transcription factor ATF4.

Gene Ontology (GO) - Molecular Function for ZNF268 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding NAS 11311945
GO:0003700 transcription factor activity, sequence-specific DNA binding NAS 11311945
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF268: view
genes like me logo Genes that share phenotypes with ZNF268: view

Animal Model Products

miRNA for ZNF268 Gene

miRTarBase miRNAs that target ZNF268

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF268 Gene

Localization for ZNF268 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF268 Gene

Isoform 1: Nucleus.
Isoform 2: Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF268 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for ZNF268 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus NAS 11311945
GO:0005737 cytoplasm IEA,IDA 15547661
GO:0015629 actin cytoskeleton IDA --
genes like me logo Genes that share ontologies with ZNF268: view

Pathways & Interactions for ZNF268 Gene

SuperPathways for ZNF268 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF268: view

Pathways by source for ZNF268 Gene

2 Reactome pathways for ZNF268 Gene

Interacting Proteins for ZNF268 Gene

SIGNOR curated interactions for ZNF268 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for ZNF268 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 12822888
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,NAS 11311945
GO:0007346 regulation of mitotic cell cycle IMP 23946776
GO:0008284 positive regulation of cell proliferation IMP 23091055
genes like me logo Genes that share ontologies with ZNF268: view

Transcripts for ZNF268 Gene

Unigene Clusters for ZNF268 Gene

Zinc finger protein 268:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF268 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b
SP1: - - - -
SP2: - - -
SP3: - - - - - -
SP4: - - -
SP5: - -
SP6: - - -
SP7: - -
SP8: -
SP9: - - - -

Relevant External Links for ZNF268 Gene

GeneLoc Exon Structure for
ZNF268
ECgene alternative splicing isoforms for
ZNF268

Expression for ZNF268 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF268 Gene

Protein differential expression in normal tissues from HIPED for ZNF268 Gene

This gene is overexpressed in Cerebral cortex (34.4), Placenta (10.5), and Kidney (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF268 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZNF268 Gene:

ZNF268

SOURCE GeneReport for Unigene cluster for ZNF268 Gene:

Hs.124047

mRNA Expression by UniProt/SwissProt for ZNF268 Gene:

Q14587-ZN268_HUMAN
Tissue specificity: Overexpressed in ovarian cancer tissues compared to normal ovarian tissues. Isoform 1 and isoform 2 are expressed in squamous epithelium tissues. Isoform 2 is overexpressed in squamous cervical cancer (at protein level). Expressed in blood cells. Isoform 1 is expressed in pancreas, lung, skeletal muscle, heart, placenta, liver, kidney and brain. Isoform 2 expressed in chronic lymphocytic leukemia (CLL) and several tumor cell lines. Isoform 3 is expressed in several tumor cells. Isoform 5 is expressed in fetal liver and several tumor cells. Isoform 6 is weakly expressed in brain, lung amd small intestin and in several tumor cells. Isoform 7 is expressed in fetal liver and several tumor cells.
genes like me logo Genes that share expression patterns with ZNF268: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for ZNF268 Gene

Orthologs for ZNF268 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF268 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF268 34 35
  • 99.26 (n)
dog
(Canis familiaris)
Mammalia ZNF268 34 35
  • 86.37 (n)
cow
(Bos Taurus)
Mammalia ZNF268 35
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia LOC102636383 34
  • 61.96 (n)
Zfp658 35
  • 41 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 50 (a)
ManyToMany
-- 35
  • 50 (a)
ManyToMany
-- 35
  • 49 (a)
ManyToMany
-- 35
  • 49 (a)
ManyToMany
-- 35
  • 47 (a)
ManyToMany
-- 35
  • 47 (a)
ManyToMany
-- 35
  • 46 (a)
ManyToMany
-- 35
  • 44 (a)
ManyToMany
-- 35
  • 43 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 44 (a)
ManyToMany
-- 35
  • 41 (a)
ManyToMany
-- 35
  • 38 (a)
ManyToMany
-- 35
  • 37 (a)
ManyToMany
-- 35
  • 33 (a)
ManyToMany
CSA.1668 35
  • 32 (a)
ManyToMany
Species where no ortholog for ZNF268 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF268 Gene

ENSEMBL:
Gene Tree for ZNF268 (if available)
TreeFam:
Gene Tree for ZNF268 (if available)

Paralogs for ZNF268 Gene

Pseudogenes.org Pseudogenes for ZNF268 Gene

genes like me logo Genes that share paralogs with ZNF268: view

Variants for ZNF268 Gene

Sequence variations from dbSNP and Humsavar for ZNF268 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10747098 -- 133,190,215(+) TTTTC(A/T)TGTCT intron-variant
rs10870588 -- 133,185,497(+) GAACA(C/G)AGGTG intron-variant
rs10870589 -- 133,191,687(+) GGAGG(C/G)CTTCT intron-variant
rs10870590 -- 133,193,260(+) CCCAT(A/G)AATTT intron-variant
rs111242543 -- 133,188,976(+) AGCTC(A/C)TAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF268 Gene

Variant ID Type Subtype PubMed ID
esv27162 CNV gain+loss 19812545
esv2675589 CNV deletion 23128226
dgv534e212 CNV gain 25503493
dgv3060n54 CNV gain 21841781
dgv220n27 CNV gain 19166990
dgv1597n100 CNV gain 25217958
dgv1596n100 CNV gain 25217958
dgv1595n100 CNV gain 25217958
dgv1593n100 CNV gain 25217958
dgv1590n100 CNV gain 25217958
nsv826570 CNV gain 20364138
nsv561149 CNV gain 21841781
nsv561148 CNV loss 21841781
nsv518970 CNV gain 19592680
nsv514654 CNV gain 21397061
nsv481333 CNV novel sequence insertion 20440878
nsv480562 CNV novel sequence insertion 20440878
nsv480559 CNV novel sequence insertion 20440878
nsv480205 CNV novel sequence insertion 20440878
nsv480120 CNV novel sequence insertion 20440878
nsv480010 CNV novel sequence insertion 20440878
nsv479882 CNV novel sequence insertion 20440878
nsv479421 CNV novel sequence insertion 20440878
nsv477977 CNV novel sequence insertion 20440878
nsv475893 CNV novel sequence insertion 20440878
nsv475613 CNV novel sequence insertion 20440878
nsv475500 CNV novel sequence insertion 20440878
nsv474776 CNV novel sequence insertion 20440878
nsv474472 CNV novel sequence insertion 20440878
nsv472460 CNV novel sequence insertion 20440878
nsv470337 CNV loss 18288195
nsv455818 CNV loss 19166990
nsv442301 CNV gain 18776908
nsv1138191 CNV deletion 24896259
nsv1121493 CNV deletion 24896259
nsv1046905 CNV loss 25217958
esv3631334 CNV loss 21293372
esv3631333 CNV gain 21293372
esv3631327 CNV gain 21293372
esv3631326 CNV loss 21293372
esv3550103 CNV deletion 23714750
esv3445364 CNV duplication 20981092
esv3434458 CNV duplication 20981092
esv3347155 CNV duplication 20981092
esv3249 CNV loss 18987735
esv2763014 CNV gain 21179565
esv2760921 CNV gain 21179565

Variation tolerance for ZNF268 Gene

Gene Damage Index Score: 8.30; 85.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF268 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF268

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF268 Gene

Disorders for ZNF268 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF268 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
ovarian cancer
  • malignant ovarian tumor
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZNF268

Genetic Association Database (GAD)
ZNF268
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF268
genes like me logo Genes that share disorders with ZNF268: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF268 Gene

Publications for ZNF268 Gene

  1. A splice variant of the C(2)H(2)-type zinc finger protein, ZNF268s, regulates NF-kappaB activation by TNF-alpha. (PMID: 18677094) Chun J.N. … Kang S.W. (Mol. Cells 2008) 3 4 22 64
  2. Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937. (PMID: 7865130) Abrink M. … Hellman L. (DNA Cell Biol. 1995) 2 3 4 64
  3. Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1. (PMID: 23665872) Wang W. … Huang Z. (Cell. Mol. Life Sci. 2013) 3 4 64
  4. Aberrant expression of ZNF268 alters the growth and migration of ovarian cancer cells. (PMID: 23946776) Hu L. … Guo M. (Oncol. Lett. 2013) 3 4 64
  5. Knockdown of ZNF268, which is transcriptionally downregulated by GATA-1, promotes proliferation of K562 cells. (PMID: 22235304) Zeng Y. … Li W. (PLoS ONE 2012) 3 4 64

Products for ZNF268 Gene

Sources for ZNF268 Gene

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