ZNF267 Gene
protein-coding GIFtS: 51
GCID: GC16P031885
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zinc finger protein 267
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Aliases
for ZNF267 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 2671 2 | | HZF21 2 5 | | Zinc Finger Protein HZF22 3 | | Zinc Finger (C2H2)2 | | Zinc Finger Protein 22 |
Export aliases for ZNF267 gene to outside databasesPrevious GC identifers: GC16P030966 GC16P032222 GC16P031723 GC16P031760 GC16P031633 GC16P031792 GC16P029445 |
Summaries
for ZNF267 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN267_HUMAN, Q14586Function: May be involved in transcriptional regulation
Gene Wiki entry for ZNF267
|
Genomic Views
for ZNF267 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF267 gene promoter:
p53 AML1a HTF Nkx2-5 XBP-1 Gfi-1 C/EBPalpha GATA-1 MRF-2 En-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF267
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF267 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p11.2 Ensembl cytogenetic band: 16p11.2 HGNC cytogenetic band: 16p11.2ZNF267 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P031885: view genomic region
(about GC identifiers)
Start:
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31,885,079 bp from pter |
End:
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31,928,668 bp from pter |
Size:
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43,590 bases |
Orientation:
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plus strand |
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Proteins
for ZNF267 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN267_HUMAN, Q14586 (See
protein sequence)Recommended Name: Zinc finger protein 267 Size: 743 amino acids; 87376 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: A0JNZ9 Q8NE41 Q9NRJ0Explore the universe of human proteins at neXtProt for ZNF267: NX_Q14586
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q14586
ZNF267 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001252517.1 NP_003405.3
ENSEMBL proteins: ENSP00000300870 ENSP00000461286 ENSP00000454753 ENSP00000454369 ENSP00000455493 Reactome Protein details: Q14586
Human Recombinant Protein Products for ZNF267:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZNF267 for ontologies About GeneDecksing
ZNF267 Antibody Products:
Assay Products for ZNF267: |
Protein
Domains /
Families
for ZNF267 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF267 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q14586ProtoNet protein and cluster: Q14586 1 Blocks protein family: IPB001909 KRAB box
UniProtKB/Swiss-Prot: ZN267_HUMAN, Q14586Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 15 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF267 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: ZN267_HUMAN, Q14586Function: May be involved in transcriptional regulation Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZNF267 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF267
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF267
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZNF267 (NM_003414) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF267 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF267 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF267 |
|
Pathways & Interactions
for ZNF267 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF267
ZNF267 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZNF267
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for ZNF267 (ENSP000003008704) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | | GO:0007275 | multicellular organismal development |
TAS | 7865130 |
ZNF267 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF267 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF267
Search CenterWatch for drugs/clinical trials and news about ZNF267 / ZN267
|
Transcripts
for ZNF267 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF267 gene (2 alternative transcripts): NM_001265588.1 NM_003414.5 Unigene Cluster for ZNF267: Zinc finger protein 267 Hs.460645 [show with all ESTs]Unigene Representative Sequence: NM_0012655885 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000300870(uc002ecs.4) ENST00000394846 ENST00000566541 ENST00000561814
ENST00000562971
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF267
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF267
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF267 (NM_003414) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF267 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF267 |
Additional cDNA sequence: AF220492.1 AK096390.1 AK292573.1 BC036367.1 BC127088.1 BC127089.1 NR_049749.1 X78925.1 6 DOTS entries: DT.95364158 DT.95364149 DT.91797316 DT.95206177 DT.95364154 DT.92409793 24/37 AceView cDNA sequences (see all 37): BU509387 BC036367 AL040556 AA279549 AI374789 BQ773830 CD639415 X78925 BE544793 AU128446 AI473862 AF220492 AI254742 NM_003414 BE612665 BG028872 AW438900 AL832123 BM989269 BG721809 CA449434 AK096390 BG108343 AA720600
GeneLoc Exon Structure
|
Expression
for ZNF267 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF267 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAAATTTTTA
About this image
See ZNF267 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF267
SOURCE GeneReport for Unigene cluster: Hs.460645
SABiosciences Custom PCR Arrays for ZNF267
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF267
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZNF267 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF267 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF267 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF267 |
Orthologs
for ZNF267 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for ZNF267 (if available)
TreeFam Gene Tree for ZNF267 (if available) |
Paralogs
for ZNF267 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF267 gene
18/495 SIMAP similar genes for ZNF267 using alignment to 5 protein entries: ZN267_HUMAN (see all proteins)
(see all similar genes):ZNF721 ZNF818P ZNF720 ZNF624 ZNF670 ZNF527
ZNF283 ZNF66 ZNF559 ZNF232 ZNF565 ZNF78L1
ZNF250 ZNF420 ZNF28 DKFZp686N14223 KRBOX4 ZNF519
ZNF267 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ZNF267
PGOHUM00000233377
|
Genomic Variants
for ZNF267 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF267 (31885079 - 31928668 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for ZNF267
4 CNVs: 66978 43928 102247 4002 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF267 |
|
Disorders
/ Diseases
for ZNF267 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF267 for disorders About GeneDecksing
OMIM gene information: 604752
OMIM disorders: --
2  diseases for ZNF267: About MalaCardshepatitis carcinoma
Export disorders for ZNF267 gene to outside databases
|
Publications
for ZNF267 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF267 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with ZNF267) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937. (PubMed id 7865130)1, 2, 3 Abrink M.... Hellman L. (1995)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Characterization of the human zinc finger protein 267 promoter: essential role of nuclear factor Y. (PubMed id 15814297)1, 9 Hu K....Schnabl B. (2005)
- Zinc finger protein 267 is up-regulated during the activation process of human hepatic stellate cells and functions as a negative transcriptional regulator of MMP-10. (PubMed id 16054593)1, 9 Schnabl B....Scholmerich J. (2005)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Increased expression of zinc finger protein 267 in non -alcoholic fatty liver disease. (PubMed id 22076166)1 Schnabl B....Hellerbrand C. (2011)
- Zinc finger protein 267 is up-regulated in hepatocell ular carcinoma and promotes tumor cell proliferation and migration. (PubMed id 21840307)1 Schnabl B....Hellerbrand C. (2011)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1 Olsen J.V....Mann M. (2006)
|
External Searches for ZNF267 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF267 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF267 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF267 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF267 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF267 gene:
Search GeneIP for patents involving ZNF267
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF267 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF267 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF267 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF267 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF267 | | OriGene 3'-UTR Clone for ZNF267 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF267 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF267 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | Search Tocris compounds for ZNF267 |
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 | | | ZNF267 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF267 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF267 |
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