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Aliases for ZNF266 Gene

Aliases for ZNF266 Gene

  • Zinc Finger Protein 266 2 3 5
  • Zinc Finger Protein HZF1 3 4
  • Zinc Finger Protein 1 3
  • KIAA2007 4
  • HZF1 3

External Ids for ZNF266 Gene

Previous GeneCards Identifiers for ZNF266 Gene

  • GC19M009644
  • GC19M009745
  • GC19M009368
  • GC19M009267
  • GC19M009523
  • GC19M009104

Summaries for ZNF266 Gene

Entrez Gene Summary for ZNF266 Gene

  • This gene encodes a protein containing many tandem zinc-finger motifs. Zinc fingers are protein or nucleic acid-binding domains, and may be involved in a variety of functions, including regulation of transcription. This gene is located in a cluster of similar genes encoding zinc finger proteins on chromosome 19. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Sep 2012]

GeneCards Summary for ZNF266 Gene

ZNF266 (Zinc Finger Protein 266) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF562.

UniProtKB/Swiss-Prot for ZNF266 Gene

  • May be involved in transcriptional regulation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF266 Gene

Genomics for ZNF266 Gene

Regulatory Elements for ZNF266 Gene

Enhancers for ZNF266 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF266 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF266 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF266 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the ZNF266 gene promoter:

Genomic Location for ZNF266 Gene

Chromosome:
19
Start:
9,412,426 bp from pter
End:
9,435,578 bp from pter
Size:
23,153 bases
Orientation:
Minus strand

Genomic View for ZNF266 Gene

Genes around ZNF266 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF266 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF266 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF266 Gene

Proteins for ZNF266 Gene

  • Protein details for ZNF266 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14584-ZN266_HUMAN
    Recommended name:
    Zinc finger protein 266
    Protein Accession:
    Q14584
    Secondary Accessions:
    • A0AV90
    • A4FU85
    • Q6IQ07
    • Q6U8A5
    • Q8IVG3
    • Q8WVX1
    • Q96SX9

    Protein attributes for ZNF266 Gene

    Size:
    549 amino acids
    Molecular mass:
    62116 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AK027480; Type=Erroneous termination; Positions=536; Note=Translated as Arg.; Evidence={ECO:0000305}; Sequence=AK027480; Type=Frameshift; Positions=461; Evidence={ECO:0000305}; Sequence=BAC23104.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF266 Gene

Proteomics data for ZNF266 Gene at MOPED

Post-translational modifications for ZNF266 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF266 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for ZNF266

No data available for DME Specific Peptides for ZNF266 Gene

Domains & Families for ZNF266 Gene

Gene Families for ZNF266 Gene

Protein Domains for ZNF266 Gene

Suggested Antigen Peptide Sequences for ZNF266 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14584

UniProtKB/Swiss-Prot:

ZN266_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 14 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 14 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF266: view

Function for ZNF266 Gene

Molecular function for ZNF266 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF266: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF266 Gene

Localization for ZNF266 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF266 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF266 Gene COMPARTMENTS Subcellular localization image for ZNF266 gene
Compartment Confidence
nucleus 5
cytosol 3

No data available for Gene Ontology (GO) - Cellular Components for ZNF266 Gene

Pathways & Interactions for ZNF266 Gene

SuperPathways for ZNF266 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF266: view

Pathways by source for ZNF266 Gene

2 Reactome pathways for ZNF266 Gene

Gene Ontology (GO) - Biological Process for ZNF266 Gene

None

No data available for SIGNOR curated interactions for ZNF266 Gene

Drugs & Compounds for ZNF266 Gene

No Compound Related Data Available

Transcripts for ZNF266 Gene

Unigene Clusters for ZNF266 Gene

Zinc finger protein 266:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF266 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9a · 9b ^ 10a ·
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - - - - - - - - -
SP4: - - - -
SP5: - -
SP6: - - - - - - - -
SP7: - - - -
SP8:
SP9: - - - - - - - - - -
SP10: -
SP11: - - - - - - - - -
SP12: - - - - - - - - - - - -
SP13: - - -
SP14:
SP15: - - - - - - - -
SP16: - - - - - - - - - - - - - - - - - - - -
SP17: - - - - - - - - - - - - - -

ExUns: 10b ^ 11 ^ 12 ^ 13a · 13b · 13c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16: - - -
SP17:

Relevant External Links for ZNF266 Gene

GeneLoc Exon Structure for
ZNF266
ECgene alternative splicing isoforms for
ZNF266

Expression for ZNF266 Gene

mRNA expression in normal human tissues for ZNF266 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for ZNF266 Gene Hs.656185

genes like me logo Genes that share expression patterns with ZNF266: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZNF266 Gene

Orthologs for ZNF266 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF266 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Zfp266 35
  • 65.91 (n)
  • 49.43 (a)
Zfp266 16
Zfp846 36
  • 43 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia ZNF266 35
  • 99.27 (n)
  • 98.91 (a)
ZNF266 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp266 35
  • 65.4 (n)
  • 49.52 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 36 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 46 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG10274 37
  • 38 (a)
D19A 37
  • 34 (a)
Species with no ortholog for ZNF266:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF266 Gene

ENSEMBL:
Gene Tree for ZNF266 (if available)
TreeFam:
Gene Tree for ZNF266 (if available)

Paralogs for ZNF266 Gene

Paralogs for ZNF266 Gene

(467) SIMAP similar genes for ZNF266 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF266: view

Variants for ZNF266 Gene

Sequence variations from dbSNP and Humsavar for ZNF266 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10515 - 9,413,048(-) GAAAC(C/T)GTATG utr-variant-3-prime
rs7258023 -- 9,415,237(+) TTGCA(A/G)TGAGC intron-variant
rs7258150 -- 9,415,341(+) CCCCA(A/G)GTCAT intron-variant
rs7258361 -- 9,423,926(+) cggga(A/G)gtgga intron-variant
rs7258744 -- 9,424,291(+) AAAGG(A/G)AAACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF266 Gene

Variant ID Type Subtype PubMed ID
nsv911020 CNV Gain 21882294
nsv2412 CNV Loss 18451855

Variation tolerance for ZNF266 Gene

Residual Variation Intolerance Score: 43.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.99; 49.77% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF266 Gene

Disorders for ZNF266 Gene

Relevant External Links for ZNF266

Genetic Association Database (GAD)
ZNF266
Human Genome Epidemiology (HuGE) Navigator
ZNF266
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF266

No disorders were found for ZNF266 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF266 Gene

Publications for ZNF266 Gene

  1. Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937. (PMID: 7865130) Abrink M. … Hellman L. (DNA Cell Biol. 1995) 2 3 4 67
  2. Identification of the trans-activation domain and the nuclear location signals of human zinc finger protein HZF1 (ZNF16). (PMID: 19763908) Deng M.J. … Zhang J.W. (Mol. Biotechnol. 2010) 3 23
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Identification of HZF1 as a novel target gene of the MEF2 transcription factor. (PMID: 21468593) Liu X. … Li X.Q. (Mol Med Rep 2011) 3
  5. Zinc finger protein HZF1 promotes K562 cell proliferation by interacting with and inhibiting INCA1. (PMID: 21874239) Li X.B. … Zhang J.W. (Mol Med Rep 2011) 3

Products for ZNF266 Gene

Sources for ZNF266 Gene

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