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Aliases for ZNF266 Gene

Aliases for ZNF266 Gene

  • Zinc Finger Protein 266 2 3 5
  • Zinc Finger Protein HZF1 3 4
  • Zinc Finger Protein 1 3
  • KIAA2007 4
  • HZF1 3

External Ids for ZNF266 Gene

Previous GeneCards Identifiers for ZNF266 Gene

  • GC19M009644
  • GC19M009745
  • GC19M009368
  • GC19M009267
  • GC19M009523
  • GC19M009104

Summaries for ZNF266 Gene

Entrez Gene Summary for ZNF266 Gene

  • This gene encodes a protein containing many tandem zinc-finger motifs. Zinc fingers are protein or nucleic acid-binding domains, and may be involved in a variety of functions, including regulation of transcription. This gene is located in a cluster of similar genes encoding zinc finger proteins on chromosome 19. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Sep 2012]

GeneCards Summary for ZNF266 Gene

ZNF266 (Zinc Finger Protein 266) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF560.

UniProtKB/Swiss-Prot for ZNF266 Gene

  • May be involved in transcriptional regulation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF266 Gene

Genomics for ZNF266 Gene

Regulatory Elements for ZNF266 Gene

Enhancers for ZNF266 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F009434 1.1 ENCODE 109.6 +0.1 98 2.4 HDGF ATF1 CREB3L1 ARID4B SIN3A DMAP1 ZNF48 BRCA1 ZNF2 YY1 ZNF266 GC19P009427
GH19F009406 0.9 ENCODE 115.1 +28.4 28432 1.2 HDAC1 ATF1 PKNOX1 CBX3 TBL1XR1 CREB3L1 ZBTB40 CBX5 ELK1 KDM4B ZNF266 FBXL12 EIF3G HNRNPM ZNF561 ZNF699 ZNF558 ICAM1 ENSG00000283108 GC19P009427
GH19F009323 1.1 ENCODE 79.2 +111.4 111444 2.0 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 ZNF266 ZNF559 ZNF561 HNRNPM FBXL12 ZNF558 ZNF699 ZNF121 ZNF562 EIF3G
GH19F009308 0.9 ENCODE 75.1 +126.1 126076 2.1 HDGF TBP HDAC1 ATF1 PKNOX1 ARID4B SIN3A ZNF48 ZEB1 YY1 ZNF266 ZNF699 ENSG00000267510
GH19F009431 0.5 ENCODE 111.8 +3.9 3899 0.2 CTCF SMC3 RAD21 ZNF266 GC19P009427
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF266 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF266 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000042871 277 2599 HDGF ATF1 CREB3L1 ARID4B SIN3A DMAP1 ZNF48 BRCA1 ZNF2 YY1

Transcription factor binding sites by QIAGEN in the ZNF266 gene promoter:

Genomic Location for ZNF266 Gene

Chromosome:
19
Start:
9,412,426 bp from pter
End:
9,435,578 bp from pter
Size:
23,153 bases
Orientation:
Minus strand

Genomic View for ZNF266 Gene

Genes around ZNF266 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF266 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF266 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF266 Gene

Proteins for ZNF266 Gene

  • Protein details for ZNF266 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14584-ZN266_HUMAN
    Recommended name:
    Zinc finger protein 266
    Protein Accession:
    Q14584
    Secondary Accessions:
    • A0AV90
    • A4FU85
    • Q6IQ07
    • Q6U8A5
    • Q8IVG3
    • Q8WVX1
    • Q96SX9

    Protein attributes for ZNF266 Gene

    Size:
    549 amino acids
    Molecular mass:
    62116 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AK027480; Type=Erroneous termination; Positions=536; Note=Translated as Arg.; Evidence={ECO:0000305}; Sequence=AK027480; Type=Frameshift; Positions=461; Evidence={ECO:0000305}; Sequence=BAC23104.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF266 Gene

Post-translational modifications for ZNF266 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF266 Gene

Domains & Families for ZNF266 Gene

Gene Families for ZNF266 Gene

Suggested Antigen Peptide Sequences for ZNF266 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14584

UniProtKB/Swiss-Prot:

ZN266_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 14 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 14 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF266: view

Function for ZNF266 Gene

Molecular function for ZNF266 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF266 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF266: view
genes like me logo Genes that share phenotypes with ZNF266: view

Animal Models for ZNF266 Gene

MGI Knock Outs for ZNF266:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF266 Gene

Localization for ZNF266 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF266 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF266 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for ZNF266 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF266: view

Pathways & Interactions for ZNF266 Gene

SuperPathways for ZNF266 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF266: view

Pathways by source for ZNF266 Gene

2 Reactome pathways for ZNF266 Gene

Gene Ontology (GO) - Biological Process for ZNF266 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF266: view

No data available for SIGNOR curated interactions for ZNF266 Gene

Transcripts for ZNF266 Gene

Unigene Clusters for ZNF266 Gene

Zinc finger protein 266:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF266 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9a · 9b ^ 10a ·
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - - - - - - - - -
SP4: - - - -
SP5: - -
SP6: - - - - - - - -
SP7: - - - -
SP8:
SP9: - - - - - - - - - -
SP10: -
SP11: - - - - - - - - -
SP12: - - - - - - - - - - - -
SP13: - - -
SP14:
SP15: - - - - - - - -
SP16: - - - - - - - - - - - - - - - - - - - -
SP17: - - - - - - - - - - - - - -

ExUns: 10b ^ 11 ^ 12 ^ 13a · 13b · 13c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16: - - -
SP17:

Relevant External Links for ZNF266 Gene

GeneLoc Exon Structure for
ZNF266
ECgene alternative splicing isoforms for
ZNF266

Expression for ZNF266 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF266 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of ZNF266 Gene:

ZNF266

SOURCE GeneReport for Unigene cluster for ZNF266 Gene:

Hs.656185
genes like me logo Genes that share expression patterns with ZNF266: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ZNF266 Gene

Orthologs for ZNF266 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF266 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF266 34 35
  • 99.27 (n)
mouse
(Mus musculus)
Mammalia Zfp266 34 16
  • 65.91 (n)
Zfp846 35
  • 43 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Zfp266 34
  • 65.4 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 46 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 36 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG10274 36
  • 38 (a)
D19A 36
  • 34 (a)
Species where no ortholog for ZNF266 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF266 Gene

ENSEMBL:
Gene Tree for ZNF266 (if available)
TreeFam:
Gene Tree for ZNF266 (if available)

Paralogs for ZNF266 Gene

Paralogs for ZNF266 Gene

(467) SIMAP similar genes for ZNF266 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF266: view

Variants for ZNF266 Gene

Sequence variations from dbSNP and Humsavar for ZNF266 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10401760 -- 9,432,175(+) gctgg(C/T)cttca intron-variant
rs10403167 -- 9,427,905(+) CATAT(G/T)CCTGA intron-variant
rs10404268 -- 9,430,964(+) TCTGT(A/G)AGGAA intron-variant
rs10404721 -- 9,431,157(+) CTGCA(A/C)AAGGG intron-variant
rs10405230 -- 9,436,154(+) ttccc(C/G)cagag intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNF266 Gene

Variant ID Type Subtype PubMed ID
nsv2412 CNV deletion 18451855

Variation tolerance for ZNF266 Gene

Residual Variation Intolerance Score: 43.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.99; 49.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF266 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF266

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF266 Gene

Disorders for ZNF266 Gene

Relevant External Links for ZNF266

Genetic Association Database (GAD)
ZNF266
Human Genome Epidemiology (HuGE) Navigator
ZNF266
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF266

No disorders were found for ZNF266 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF266 Gene

Publications for ZNF266 Gene

  1. Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937. (PMID: 7865130) Abrink M. … Hellman L. (DNA Cell Biol. 1995) 2 3 4 64
  2. Identification of the trans-activation domain and the nuclear location signals of human zinc finger protein HZF1 (ZNF16). (PMID: 19763908) Deng M.J. … Zhang J.W. (Mol. Biotechnol. 2010) 3 22 64
  3. Analysis of SNPs with an effect on gene expression identifies UBE2L3 and BCL3 as potential new risk genes for Crohn's disease. (PMID: 20601676) Fransen K. … Weersma R.K. (Hum. Mol. Genet. 2010) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for ZNF266 Gene

Sources for ZNF266 Gene

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