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Aliases for ZNF264 Gene

Aliases for ZNF264 Gene

  • Zinc Finger Protein 264 2 3 5
  • KIAA0412 4

External Ids for ZNF264 Gene

Previous GeneCards Identifiers for ZNF264 Gene

  • GC19P058601
  • GC19P058156
  • GC19P062378
  • GC19P062394
  • GC19P057702
  • GC19P054015

Summaries for ZNF264 Gene

Entrez Gene Summary for ZNF264 Gene

  • This gene encodes a zinc finger protein and belongs to the krueppel C2H2-type zinc-finger protein family. Zinc finger proteins are often localized in the nucleus, bind nucleic acids, and regulate transcription. [provided by RefSeq, Jan 2010]

GeneCards Summary for ZNF264 Gene

ZNF264 (Zinc Finger Protein 264) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF460.

UniProtKB/Swiss-Prot for ZNF264 Gene

  • May be involved in transcriptional regulation.

Gene Wiki entry for ZNF264 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF264 Gene

Genomics for ZNF264 Gene

Regulatory Elements for ZNF264 Gene

Enhancers for ZNF264 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF264 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF264 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF264 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF264 Gene

Chromosome:
19
Start:
57,191,479 bp from pter
End:
57,222,846 bp from pter
Size:
31,368 bases
Orientation:
Plus strand

Genomic View for ZNF264 Gene

Genes around ZNF264 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF264 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF264 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF264 Gene

Proteins for ZNF264 Gene

  • Protein details for ZNF264 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43296-ZN264_HUMAN
    Recommended name:
    Zinc finger protein 264
    Protein Accession:
    O43296
    Secondary Accessions:
    • A8K8Y9
    • Q9P1V0

    Protein attributes for ZNF264 Gene

    Size:
    627 amino acids
    Molecular mass:
    70587 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA24842.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF264 Gene

Proteomics data for ZNF264 Gene at MOPED

Post-translational modifications for ZNF264 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF264 Gene

No data available for DME Specific Peptides for ZNF264 Gene

Domains & Families for ZNF264 Gene

Gene Families for ZNF264 Gene

Protein Domains for ZNF264 Gene

Suggested Antigen Peptide Sequences for ZNF264 Gene

Graphical View of Domain Structure for InterPro Entry

O43296

UniProtKB/Swiss-Prot:

ZN264_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 13 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 13 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF264: view

Function for ZNF264 Gene

Molecular function for ZNF264 Gene

GENATLAS Biochemistry:
Kruppel-related zinc finger protein 264 ,Kruppel related
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes for ZNF264 Gene

genes like me logo Genes that share phenotypes with ZNF264: view

Animal Model Products

CRISPR Products

miRNA for ZNF264 Gene

miRTarBase miRNAs that target ZNF264
Targeted motifs for ZNF264 Gene
HOMER Transcription Factor Regulatory Elements motif ZNF264
  • Consensus sequence: RGGGCACTAACY Submotif: canonical Cell Type: HEK293 GEO ID: GSE58341

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models and Transcription Factor Targets for ZNF264 Gene

Localization for ZNF264 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF264 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF264 Gene COMPARTMENTS Subcellular localization image for ZNF264 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF264 Gene

Pathways & Interactions for ZNF264 Gene

SuperPathways for ZNF264 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF264: view

Pathways by source for ZNF264 Gene

2 Reactome pathways for ZNF264 Gene

Interacting Proteins for ZNF264 Gene

Gene Ontology (GO) - Biological Process for ZNF264 Gene

None

No data available for SIGNOR curated interactions for ZNF264 Gene

Drugs & Compounds for ZNF264 Gene

No Compound Related Data Available

Transcripts for ZNF264 Gene

Unigene Clusters for ZNF264 Gene

Zinc finger protein 264:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF264 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b
SP1: -
SP2: - - -
SP3: - -
SP4:

Relevant External Links for ZNF264 Gene

GeneLoc Exon Structure for
ZNF264
ECgene alternative splicing isoforms for
ZNF264

Expression for ZNF264 Gene

mRNA expression in normal human tissues for ZNF264 Gene

Protein differential expression in normal tissues from HIPED for ZNF264 Gene

This gene is overexpressed in CD8 Tcells (55.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF264 Gene



SOURCE GeneReport for Unigene cluster for ZNF264 Gene Hs.515634

mRNA Expression by UniProt/SwissProt for ZNF264 Gene

O43296-ZN264_HUMAN
Tissue specificity: Relatively highly expressed in kidney, thymus, testis, ovary, brain, lung, placenta, and prostate, and relatively low expression in heart, liver, skeletal muscle, pancreas, spleen, and small intestine.
genes like me logo Genes that share expression patterns with ZNF264: view

Protein tissue co-expression partners for ZNF264 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZNF264 Gene

Orthologs for ZNF264 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF264 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia ZNF264 35
  • 85.62 (n)
  • 84.64 (a)
ZNF264 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZNF264 35
  • 99.2 (n)
  • 99.36 (a)
ZNF264 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 42 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii CU138542.3 36
  • 43 (a)
ManyToMany
si:dkey-7j22.3 36
  • 52 (a)
ManyToMany
Species with no ortholog for ZNF264:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF264 Gene

ENSEMBL:
Gene Tree for ZNF264 (if available)
TreeFam:
Gene Tree for ZNF264 (if available)

Paralogs for ZNF264 Gene

Paralogs for ZNF264 Gene

(499) SIMAP similar genes for ZNF264 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ZNF264: view

Variants for ZNF264 Gene

Sequence variations from dbSNP and Humsavar for ZNF264 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs2074858 - 57,211,639(+) AGATA(A/C/G)AGTCC reference, missense
rs917340 - 57,211,645(+) AGTCC(A/G/T)TAGCC reference, missense
rs758096 -- 57,221,817(+) GGGCA(C/G)TGAGC utr-variant-3-prime
rs7256132 -- 57,202,352(+) GGGGA(C/T)ACAGC intron-variant
rs7257105 -- 57,197,140(+) caggc(C/T)ggggg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF264 Gene

Variant ID Type Subtype PubMed ID
esv2662848 CNV Deletion 23128226
esv2663783 CNV Deletion 23128226

Variation tolerance for ZNF264 Gene

Residual Variation Intolerance Score: 41.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.51; 29.44% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF264 Gene

Disorders for ZNF264 Gene

Relevant External Links for ZNF264

Genetic Association Database (GAD)
ZNF264
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF264

No disorders were found for ZNF264 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF264 Gene

Publications for ZNF264 Gene

  1. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9455477) Ishikawa K. … Ohara O. (DNA Res. 1997) 2 3 4 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Wnt signaling and Dupuytren's disease. (PMID: 21732829) Dolmans G.H. … . (N. Engl. J. Med. 2011) 3
  4. Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. (PMID: 20562864) Nozawa R.S. … Obuse C. (Nat. Cell Biol. 2010) 3
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for ZNF264 Gene

Sources for ZNF264 Gene

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