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Aliases for ZNF264 Gene

Aliases for ZNF264 Gene

  • Zinc Finger Protein 264 2 3 5
  • KIAA0412 4

External Ids for ZNF264 Gene

Previous GeneCards Identifiers for ZNF264 Gene

  • GC19P058601
  • GC19P058156
  • GC19P062378
  • GC19P062394
  • GC19P057702
  • GC19P054015

Summaries for ZNF264 Gene

Entrez Gene Summary for ZNF264 Gene

  • This gene encodes a zinc finger protein and belongs to the krueppel C2H2-type zinc-finger protein family. Zinc finger proteins are often localized in the nucleus, bind nucleic acids, and regulate transcription. [provided by RefSeq, Jan 2010]

GeneCards Summary for ZNF264 Gene

ZNF264 (Zinc Finger Protein 264) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF805.

UniProtKB/Swiss-Prot for ZNF264 Gene

  • May be involved in transcriptional regulation.

Gene Wiki entry for ZNF264 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF264 Gene

Genomics for ZNF264 Gene

Regulatory Elements for ZNF264 Gene

Enhancers for ZNF264 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G057809 1.7 FANTOM5 ENCODE dbSUPER 61.8 +621.7 621739 7.2 CREB3L1 MLX ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 ZNF134 ZNF264 TRIM28 ZNF17 ZNF417 ZNF256 ZNF543 ZNF805 ZNF606 ZNF773
GH19G056594 1 ENCODE 40.2 -596.0 -596039 1.4 HDGF PKNOX1 ZNF133 ARID4B SIN3A FEZF1 YBX1 GLI4 ZNF48 YY1 ZNF17 ENSG00000269696 ZNF549 ZNF773 ZNF543 U2AF2 ZFP28 ZNF667 ZNF470 FIZ1
GH19G058181 1.1 ENCODE 30.9 +991.8 991758 2.5 HDGF PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ZNF134 ZNF549 ZNF606 ZNF773 ZNF17 ZNF418 ZNF550 ZNF417 ZNF256 ZNF543
GH19G057239 1.1 ENCODE 30.1 +49.7 49670 2.6 PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 ZNF143 ZNF264 ZNF134 ZNF543 ZNF551 ZNF211 ZNF805 AURKC ZNF606 ZNF471 ZNF549
GH19G056403 1.1 ENCODE 26.9 -787.3 -787330 2.0 HDGF CREB3L1 ARNT ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF416 ZNF143 ZNF582-AS1 ZFP28 FIZ1 ZNF543 ZNF471 ZNF264 ZNF542P ZNF470 U2AF2 ENSG00000269696
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF264 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF264 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000111783 221 1801 PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 ZNF48 YY1 CBX5 ZNF143 ZNF207

Genomic Location for ZNF264 Gene

Chromosome:
19
Start:
57,191,479 bp from pter
End:
57,222,846 bp from pter
Size:
31,368 bases
Orientation:
Plus strand

Genomic View for ZNF264 Gene

Genes around ZNF264 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF264 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF264 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF264 Gene

Proteins for ZNF264 Gene

  • Protein details for ZNF264 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43296-ZN264_HUMAN
    Recommended name:
    Zinc finger protein 264
    Protein Accession:
    O43296
    Secondary Accessions:
    • A8K8Y9
    • Q9P1V0

    Protein attributes for ZNF264 Gene

    Size:
    627 amino acids
    Molecular mass:
    70587 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA24842.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF264 Gene

Post-translational modifications for ZNF264 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF264 Gene

No data available for DME Specific Peptides for ZNF264 Gene

Domains & Families for ZNF264 Gene

Gene Families for ZNF264 Gene

Protein Domains for ZNF264 Gene

Suggested Antigen Peptide Sequences for ZNF264 Gene

Graphical View of Domain Structure for InterPro Entry

O43296

UniProtKB/Swiss-Prot:

ZN264_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF264: view

Function for ZNF264 Gene

Molecular function for ZNF264 Gene

GENATLAS Biochemistry:
Kruppel-related zinc finger protein 264 ,Kruppel related
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF264 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF264: view
genes like me logo Genes that share phenotypes with ZNF264: view

Animal Model Products

CRISPR Products

miRNA for ZNF264 Gene

miRTarBase miRNAs that target ZNF264
Targeted motifs for ZNF264 Gene
HOMER Transcription Factor Regulatory Elements motif ZNF264
  • Consensus sequence: RGGGCACTAACY Submotif: canonical Cell Type: HEK293 GEO ID: GSE58341

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and Transcription Factor Targets for ZNF264 Gene

Localization for ZNF264 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF264 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF264 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF264 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF264: view

Pathways & Interactions for ZNF264 Gene

SuperPathways for ZNF264 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF264: view

Pathways by source for ZNF264 Gene

2 Reactome pathways for ZNF264 Gene

Gene Ontology (GO) - Biological Process for ZNF264 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF264: view

No data available for SIGNOR curated interactions for ZNF264 Gene

Drugs & Compounds for ZNF264 Gene

No Compound Related Data Available

Transcripts for ZNF264 Gene

Unigene Clusters for ZNF264 Gene

Zinc finger protein 264:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF264 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b
SP1: -
SP2: - - -
SP3: - -
SP4:

Relevant External Links for ZNF264 Gene

GeneLoc Exon Structure for
ZNF264
ECgene alternative splicing isoforms for
ZNF264

Expression for ZNF264 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF264 Gene

Protein differential expression in normal tissues from HIPED for ZNF264 Gene

This gene is overexpressed in CD8 Tcells (55.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF264 Gene



Protein tissue co-expression partners for ZNF264 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF264 Gene:

ZNF264

SOURCE GeneReport for Unigene cluster for ZNF264 Gene:

Hs.515634

mRNA Expression by UniProt/SwissProt for ZNF264 Gene:

O43296-ZN264_HUMAN
Tissue specificity: Relatively highly expressed in kidney, thymus, testis, ovary, brain, lung, placenta, and prostate, and relatively low expression in heart, liver, skeletal muscle, pancreas, spleen, and small intestine.

Evidence on tissue expression from TISSUES for ZNF264 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with ZNF264: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF264 Gene

Orthologs for ZNF264 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF264 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF264 34 35
  • 99.2 (n)
dog
(Canis familiaris)
Mammalia ZNF264 34 35
  • 85.62 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 42 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:dkey-7j22.3 35
  • 52 (a)
ManyToMany
CU138542.3 35
  • 43 (a)
ManyToMany
Species where no ortholog for ZNF264 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF264 Gene

ENSEMBL:
Gene Tree for ZNF264 (if available)
TreeFam:
Gene Tree for ZNF264 (if available)

Paralogs for ZNF264 Gene

Paralogs for ZNF264 Gene

(499) SIMAP similar genes for ZNF264 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ZNF264: view

Variants for ZNF264 Gene

Sequence variations from dbSNP and Humsavar for ZNF264 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000200469 -- 57,190,972(+) TGCTG(G/T)TCCAA upstream-variant-2KB
rs1000206519 -- 57,195,919(+) TTGCT(A/G)GTTGA intron-variant
rs1000223729 -- 57,203,983(+) AGATC(A/G)AGACC intron-variant
rs1000328406 -- 57,195,987(+) CCATG(A/T)ATCCT intron-variant
rs1000411689 -- 57,201,397(+) GTCCC(C/T)CGCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF264 Gene

Variant ID Type Subtype PubMed ID
dgv1093e212 CNV loss 25503493
dgv1094e212 CNV loss 25503493
esv2662848 CNV deletion 23128226
esv2663783 CNV deletion 23128226
esv3644896 CNV gain 21293372
esv3644897 CNV loss 21293372
esv3644898 CNV loss 21293372
esv3893256 CNV loss 25118596
nsv1064109 CNV gain 25217958
nsv580400 CNV gain 21841781

Variation tolerance for ZNF264 Gene

Residual Variation Intolerance Score: 41.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.51; 29.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF264 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF264

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF264 Gene

Disorders for ZNF264 Gene

Relevant External Links for ZNF264

Genetic Association Database (GAD)
ZNF264
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF264

No disorders were found for ZNF264 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF264 Gene

Publications for ZNF264 Gene

  1. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9455477) Ishikawa K. … Ohara O. (DNA Res. 1997) 2 3 4 64
  2. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J. … Comb M.J. (Nat. Biotechnol. 2005) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for ZNF264 Gene

Sources for ZNF264 Gene

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