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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF264 Gene

protein-coding   GIFtS: 54
GCID: GC19P057702

Zinc Finger Protein 264

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 2641 2
KIAA04123

External Ids:    HGNC: 130571   Entrez Gene: 94222   Ensembl: ENSG000000838447   OMIM: 6046685   UniProtKB: O432963   

Export aliases for ZNF264 gene to outside databases

Previous GC identifers: GC19P058601 GC19P058156 GC19P062378 GC19P062394 GC19P054015


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ZNF264 Gene:
This gene encodes a zinc finger protein and belongs to the krueppel C2H2-type zinc-finger protein family. Zinc
finger proteins are often localized in the nucleus, bind nucleic acids, and regulate transcription. (provided by
RefSeq, Jan 2010)

GeneCards Summary for ZNF264 Gene: 
ZNF264 (zinc finger protein 264) is a protein-coding gene. Diseases associated with ZNF264 include gastric cancer, and prostatitis, and among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF80.

UniProtKB/Swiss-Prot: ZN264_HUMAN, O43296
Function: May be involved in transcriptional regulation

Gene Wiki entry for ZNF264 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF264 gene promoter:
         GATA-3   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   Meis-1b   GATA-1   GATA-2   FAC1   Meis-1a   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF264 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF264

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF264


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.4   Ensembl cytogenetic band:  19q13.43   HGNC cytogenetic band: 19q13.4

ZNF264 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF264 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P057702:  view genomic region     (about GC identifiers)

Start:
57,702,868 bp from pter      End:
57,734,214 bp from pter
Size:
31,347 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN264_HUMAN, O43296 (See protein sequence)
Recommended Name: Zinc finger protein 264  
Size: 627 amino acids; 70587 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=BAA24842.2; Type=Erroneous initiation;
Secondary accessions: A8K8Y9 Q9P1V0

Explore the universe of human proteins at neXtProt for ZNF264: NX_O43296

Explore proteomics data for ZNF264 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O43296

  • ZNF264 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF264 Protein Expression
    REFSEQ proteins: NP_003408.1  
    ENSEMBL proteins: 
     ENSP00000263095   ENSP00000469130   ENSP00000470759   ENSP00000470587   ENSP00000471630  
     ENSP00000440376  
    Reactome Protein details: O43296
    Human Recombinant Protein Products for ZNF264: 
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZNF264 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF264 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry O43296

    ProtoNet protein and cluster: O43296

    2 Blocks protein domains:
    IPB001909 KRAB box
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZN264_HUMAN, O43296
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 13 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF264 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN264_HUMAN, O43296
    Function: May be involved in transcriptional regulation

         Genatlas biochemistry entry for ZNF264:
    Kruppel-related zinc finger protein 264 ,Kruppel related

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF264 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF264 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF264
        Generic Transcription Pathway
    Gene Expression



    ZNF264 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF264

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for ZNF264 (ENSP000002630954) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CBX5ENSP000002098754STRING: ENSP00000209875
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF264 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF264 (ZN264)

    Search CenterWatch for drugs/clinical trials and news about ZNF264 / ZN264

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF264 gene: 
    NM_003417.4  

    Unigene Cluster for ZNF264:

    Zinc finger protein 264
    Hs.515634  [show with all ESTs]
    Unigene Representative Sequence: NM_003417
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263095(uc002qob.3) ENST00000594126 ENST00000600531 ENST00000597447
    ENST00000599653 ENST00000536056
    miRNA
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    hsa-miR-4324 hsa-miR-30c hsa-miR-30d hsa-miR-3647-3p hsa-miR-570 hsa-miR-30a hsa-miR-544b hsa-miR-30b
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF264

    Additional mRNA sequence: 

    AB007872.1 AK097167.1 AK292504.1 BC115410.2 BC115411.1 

    7 DOTS entries:

    DT.114318  DT.121500227  DT.92419769  DT.121500241  DT.102824483  DT.95139047  DT.95134105 

    24/105 AceView cDNA sequences (see all 105):

    BM821845 AW976429 N50396 Z42777 BU619664 BP354221 BQ020432 F02246 
    BM693525 BQ575361 CB990703 AL047747 BF431294 AA349259 AA834890 AI688811 
    CD520344 BF589160 H86268 BX112672 M85740 BG250485 CB961204 BG288543 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF264    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b
    SP1:                                -                           
    SP2:                                -     -     -               
    SP3:                                -     -                     
    SP4:                                                            


    ECgene alternative splicing isoforms for ZNF264

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF264 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTTCAGTGG
    ZNF264 Expression
    About this image


    See ZNF264 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF264

    SOURCE GeneReport for Unigene cluster: Hs.515634

    UniProtKB/Swiss-Prot: ZN264_HUMAN, O43296
    Tissue specificity: Relatively highly expressed in kidney, thymus, testis, ovary, brain, lung, placenta, and
    prostate, and relatively low expression in heart, liver, skeletal muscle, pancreas, spleen, and small intestine

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for ZNF264 gene from 1/2 species (see all 2)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp2645 zinc finger protein 264   --   7 6977245 


    ENSEMBL Gene Tree for ZNF264 (if available)
    TreeFam Gene Tree for ZNF264 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF264 gene
    ZNF802  ZNF4602  ZNF5992  ZNF5432  ZNF5502  ZNF8052  
    18/498 SIMAP similar genes for ZNF264 using alignment to 6 protein entries:     ZN264_HUMAN (see all proteins) (see all similar genes):
    ZNF805    ZNF543    ZNF818P    kr-znf3    ZNF599    ZNF78L1
    ZNF669    ZFS-4    ZNF550    ZNF789    ZNF324B    ZNF81
    DKFZp666C237    HZF30    zf30    ZNF577    ZNF705A    ZNF844

    ZNF264 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/836 SNPs in ZNF264 are shown (see all 836)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1134145951,2
    C--54023658(+) AAGAA-/AG/GA 
            
    AAAAT
    1 -- int11CSA 2
    rs106882541,2
    C--54023660(+) AGAAA-/AG/GA 
            
    AAATG
    1 -- int1 trp30--------
    rs340435431,2
    C--54045921(+) TACATG/-GCATT 1 -- ut311Minor allele frequency- -:0.50NA 2
    rs1390061331,2
    C--54046220(+) CTCTC-/TCT   
       CTCTA
    TATAT
    1 -- ut310--------
    rs58287151,2
    H--54046224(+) TCTCtA/Ctatat 2 -- cds10--------
    rs284321851,2
    F--54046225(+) TCTCTC/ATATAT 1 -- ut311Minor allele frequency- A:0.50NA 4
    rs38332901,2
    C--54046273(-) tgtgtGTGT/-  
            
    agctt
    1 -- ut311Minor allele frequency- -:0.50CSA 2
    rs350833221,2
    C--54046275(+) ACACA-/ACA   
      C
    /CACA
    TATAC
    2 -- ut310--------
    rs114237771,2
    C,F--57704104(+) TTTTTT/-GTTTT 1 -- int12Minor allele frequency- -:0.50NA CSA 4
    rs114237761,2
    C,F--57704274(+) TTGTAT/-TTTTA 1 -- int12Minor allele frequency- -:0.50NA CSA 4

    HapMap Linkage Disequilibrium report for ZNF264 (57702868 - 57734214 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ZNF264:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2662848CNV Deletion23128226
    esv2663783CNV Deletion23128226

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604668    OMIM disorders: --

    2 diseases for ZNF264:    About MalaCards
    gastric cancer    prostatitis


    ZNF264 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZNF264

    Export disorders for ZNF264 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF264 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with ZNF264)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9455477)1, 2, 3 Ishikawa K....Ohara O. (1997)
    2. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    5. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    6. Wnt signaling and Dupuytren's disease. (PubMed id 21732829)1 Dolmans G.H.... . (2011)
    7. Human POGZ modulates dissociation of HP1alpha from mi totic chromosome arms through Aurora B activation. (PubMed id 20562864)1 Nozawa R.S....Obuse C. (2010)
    8. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    9. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    10. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PubMed id 17903300)4 Fox C.S....Atwood L.D. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9422 HGNC: 13057 AceView: ZNF264 Ensembl:ENSG00000083844 euGenes: HUgn9422
    ECgene: ZNF264 H-InvDB: ZNF264

    (According to HUGE)
    About This Section
    HUGE: KIAA0412

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF264 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF264 gene:
    Search GeneIP for patents involving ZNF264

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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