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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF263 Gene

protein-coding   GIFtS: 53
GCID: GC16P003273

zinc finger protein 263

 Explore 1 disease affiliated with
ZNF263 via our new
 Human Malady Compendium 
Biological research products
for ZNF263
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Zinc Finger Protein 2631 2
FPM3151 2 3
ZKSCAN121 2 3
ZSCAN441 2
Zinc Finger Protein FPM3152 3
Zinc Finger Protein With KRAB And SCAN Domains 122 3

External Ids:    HGNC: 130561   Entrez Gene: 101272   Ensembl: ENSG000000061947   OMIM: 6041915   UniProtKB: O149783   

Export aliases for ZNF263 gene to outside databases

Previous GC identifers: GC16P003354 GC16P003333


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZN263_HUMAN, O14978
Function: Might play an important role in basic cellular processes as a transcriptional repressor




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF263 gene promoter:
         C/EBPbeta   AML1a   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF263 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF263

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF263


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

ZNF263 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF263 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P003273:  view genomic region     (about GC identifiers)

Start:
3,313,743 bp from pter      End:
3,351,401 bp from pter
Size:
37,659 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZN263_HUMAN, O14978 (See protein sequence)
Recommended Name: Zinc finger protein 263  
Size: 683 amino acids; 77299 Da
Subcellular location: Nucleus (By similarity)
Secondary accessions: B2R634 O43387 Q96H95

Explore the universe of human proteins at neXtProt for ZNF263: NX_O14978

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O14978

  • ZNF263 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005732.2  
    ENSEMBL proteins: 
     ENSP00000444497   ENSP00000219069   ENSP00000461861   ENSP00000460278   ENSP00000459998  
     ENSP00000458214   ENSP00000461146   ENSP00000461755  
    Reactome Protein details: O14978
    Human Recombinant Protein Products: 
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ZNF263

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0015630microtubule cytoskeleton IDA--


    ZNF263 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ZNF263 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR008916 Retrov_capsid_C
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry O14978

    ProtoNet protein and cluster: O14978

    3 Blocks protein families:
    IPB001909 KRAB box
    IPB003309 Transcriptional regulator SCAN
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZN263_HUMAN, O14978
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 9 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain
    Similarity: Contains 1 SCAN box domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ZN263_HUMAN, O14978
    Function: Might play an important role in basic cellular processes as a transcriptional repressor

         Genatlas biochemistry entry for ZNF263:
    zinc finger protein 263

    miRNA
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    hsa-miR-9 hsa-miR-1288 hsa-miR-3130-3p hsa-miR-3145-3p
    SwitchGear 3'UTR luciferase reporter plasmidZNF263 3' UTR sequence
    Inhib. RNA
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0008270zinc ion binding IEA--


    ZNF263 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for ZNF263:
     G0/1 arrest  Increased G1 DNA content 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Generic Transcription Pathway
    Generic Transcription Pathway1.00
    Gene Expression0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2        Reactome Pathways for ZNF263
        Generic Transcription Pathway
    Gene Expression



    ZNF263 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF263

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/16 Interacting proteins for ZNF263 (O149782, 3 ENSP000002190694) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NME7Q9Y5B82, 3, ENSP000003567854MINT-68026 I2D: score=5 STRING: ENSP00000356785
    PLEKHF2Q9H8W42, 3, ENSP000003223734MINT-68084 I2D: score=5 STRING: ENSP00000322373
    EFEMP2O959672, 3, ENSP000003099534MINT-66519 I2D: score=4 STRING: ENSP00000309953
    SCAND1P570862, 3, ENSP000003019954MINT-67660 I2D: score=4 STRING: ENSP00000301995
    TRIM41Q8WV442, 3, ENSP000003208694MINT-67444 I2D: score=5 STRING: ENSP00000320869
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent TAS9256059
    GO:0016032viral reproduction IEA--
    GO:0045892negative regulation of transcription, DNA-dependent IEA--


    ZNF263 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF263
    Search CenterWatch for drugs/clinical trials and news about ZNF263 / ZN263 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF263 gene: 
    NM_005741.4  

    Unigene Cluster for ZNF263:

    Zinc finger protein 263
    Hs.611475  [show with all ESTs]
    Unigene Representative Sequence: NM_005741
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000573951(uc002cuo.2) ENST00000572123 ENST00000538765 ENST00000219069(uc010uww.2 uc002cuq.3)
    ENST00000572748 ENST00000573578 ENST00000574253 ENST00000575823 ENST00000575332(uc002cur.2)
    ENST00000574674

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    hsa-miR-9 hsa-miR-1288 hsa-miR-3130-3p hsa-miR-3145-3p
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    Inhib. RNA
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    Additional cDNA sequence: 

    AK295350.1 AK312421.1 BC008805.2 D88827.1 

    10 DOTS entries:

    DT.451825  DT.95091269  DT.100816297  DT.100816295  DT.100816296  DT.97847004  DT.75103061  DT.100816299 
    DT.120672482  DT.120672485 

    24/186 AceView cDNA sequences (see all 186):

    AI968375 CA441502 BM669492 BM716213 AW591399 AW070832 BQ448146 BU685083 
    BC008805 CD367126 BQ881837 AI886947 NM_005741 BQ069970 AA421783 AA351208 
    N80183 AI147238 BQ941689 AA808554 AI589317 BU732189 CR602060 BG741897 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF263    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
    SP1:                                                                  
    SP2:                    -     -     -     -                           
    SP3:                    -     -                                       
    SP4:                    -     -     -     -     -                     


    ECgene alternative splicing isoforms for ZNF263

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF263 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAAATATGAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See ZNF263 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF263

    SOURCE GeneReport for Unigene cluster: Hs.611475

    UniProtKB/Swiss-Prot: ZN263_HUMAN, O14978
    Tissue specificity: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen,
    thymus, prostate, testis, ovary, small intestine, colon and leukocyte

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF263 gene from 1/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 20)
    --
    42(a)
    41(a)
    (see all 20)
    many ↔ many
    many ↔ many
    (see all 20)
    GL343434.1(394467-394832)
    GL344760.1(2005-3288)


    ENSEMBL Gene Tree for ZNF263 (if available)
    TreeFam Gene Tree for ZNF263 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF263 gene
    ZNF4962  ZNF4492  ZNF4462  ZSCAN92  ZKSCAN12  ZNF3972  ZNF5002  ZNF2132  
    ZSCAN302  ZNF2322  ZNF2022  ZKSCAN42  ZNF1742  ZSCAN252  ZNF3962  ZSCAN122  
    ZNF3942  ZSCAN212  ZSCAN232  ZNF1652  ZSCAN162  ZKSCAN82  ZSCAN312  ZSCAN222  
    ZKSCAN32  ZNF242  ZNF182  
    18/529 SIMAP similar genes for ZNF263 using alignment to 9 protein entries:     ZN263_HUMAN (see all proteins) (see all similar genes):
    ZNF444    kr-znf3    ZNF78L1    LOC100128510    SCAND1    ZSCAN32
    ZSCAN31    ZKSCAN2    ZKSCAN8    ZNF818P    ZSCAN25    ZNF24
    ZNF542    ZNF702P    ZNF167    ZKSCAN7    ZNF148    ZNF483

    ZNF263 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ZNF263
    PGOHUM00000263004


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/198 NCBI SNPs in ZNF263 are shown (see all 198    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1461176871,2
    --3331600(+) CATAAA/GTTGCC 1 -- us2k10--------
    rs1151271861,2
    F,--3331743(+) CGACAG/AAGCAA 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1867076901,2
    --3331926(+) GCCAGA/GCGTGG 1 -- us2k10--------
    rs1929834701,2
    --3331969(+) GGCTAA/GGGCGG 1 -- us2k10--------
    rs1136391551,2
    C,--3332263(+) CACAAACCG/-  
            
    ACCCC
    1 -- us2k11Minor allele frequency- -:0.00CSA 2
    rs1847111761,2
    --3332345(+) TAAATA/GACTTC 1 -- us2k10--------
    rs1436592771,2
    --3332390(+) CATCTA/GCTTCA 1 -- us2k10--------
    rs740033451,2
    C,--3332762(+) AGACCT/CGAGCG 1 -- us2k11Minor allele frequency- C:0.00WA 2
    rs1904250701,2
    --3332763(+) GACCCC/GAGCGC 1 -- us2k10--------
    rs787692771,2
    C,F,--3332814(+) AGCAGG/CGTTCT 1 -- us2k11Minor allele frequency- C:0.11EA 120

    HapMap Linkage Disequilibrium report for ZNF263 (3313743 - 3351401 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ZNF263: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF263
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF263

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZNF263 for disorders           About GeneDecksing

    OMIM gene information: 604191    OMIM disorders: --

    1 disease for ZNF263:    About MalaCards
    prostatitis

    Human Genome Epidemiology (HuGE) Navigator: ZNF263 (1 document)

    Export disorders for ZNF263 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF263 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF263)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of a cDNA encoding a widely expressed novel zinc finger protein with the LeR and KRAB-A domains. (PubMed id 9256059)1, 2, 3 Yokoyama M.... Fukushima A. (1997)
    2. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)1, 2 Martin J.... Pennacchio L.A. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Genomic targets of the KRAB and SCAN domain-containin g zinc finger protein 263. (PubMed id 19887448)1 Frietze S....Farnham P.J. (2010)
    5. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
    6. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    7. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10127 HGNC: 13056 AceView: ZNF263 Ensembl:ENSG00000006194 euGenes: HUgn10127
    ECgene: ZNF263 H-InvDB: ZNF263

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF263 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF263 gene:
    Search GeneIP for patents involving ZNF263

    GeneCards and IP:
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