Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF263 Gene

Aliases for ZNF263 Gene

  • Zinc Finger Protein 263 2 3 5
  • Zinc Finger Protein With KRAB And SCAN Domains 12 3 4
  • Zinc Finger Protein FPM315 3 4
  • ZKSCAN12 3 4
  • FPM315 3 4
  • ZSCAN44 3

External Ids for ZNF263 Gene

Previous GeneCards Identifiers for ZNF263 Gene

  • GC16P003354
  • GC16P003333
  • GC16P003273
  • GC16P003319
  • GC16P003272

Summaries for ZNF263 Gene

GeneCards Summary for ZNF263 Gene

ZNF263 (Zinc Finger Protein 263) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF500.

UniProtKB/Swiss-Prot for ZNF263 Gene

  • Might play an important role in basic cellular processes as a transcriptional repressor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF263 Gene

Genomics for ZNF263 Gene

Regulatory Elements for ZNF263 Gene

Enhancers for ZNF263 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF263 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF263 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF263 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF263 Gene

Chromosome:
16
Start:
3,263,800 bp from pter
End:
3,301,401 bp from pter
Size:
37,602 bases
Orientation:
Plus strand

Genomic View for ZNF263 Gene

Genes around ZNF263 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF263 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF263 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF263 Gene

Proteins for ZNF263 Gene

  • Protein details for ZNF263 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14978-ZN263_HUMAN
    Recommended name:
    Zinc finger protein 263
    Protein Accession:
    O14978
    Secondary Accessions:
    • B2R634
    • O43387
    • Q96H95

    Protein attributes for ZNF263 Gene

    Size:
    683 amino acids
    Molecular mass:
    77299 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF263 Gene

Proteomics data for ZNF263 Gene at MOPED

Post-translational modifications for ZNF263 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF263 Gene

Domains & Families for ZNF263 Gene

Gene Families for ZNF263 Gene

Graphical View of Domain Structure for InterPro Entry

O14978

UniProtKB/Swiss-Prot:

ZN263_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 9 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
  • Contains 1 SCAN box domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 9 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF263: view

Function for ZNF263 Gene

Molecular function for ZNF263 Gene

GENATLAS Biochemistry:
zinc finger protein 263
UniProtKB/Swiss-Prot Function:
Might play an important role in basic cellular processes as a transcriptional repressor.

Gene Ontology (GO) - Molecular Function for ZNF263 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ZNF263: view
genes like me logo Genes that share phenotypes with ZNF263: view

Animal Model Products

CRISPR Products

miRNA for ZNF263 Gene

miRTarBase miRNAs that target ZNF263
Targeted motifs for ZNF263 Gene
HOMER Transcription Factor Regulatory Elements motif ZNF263
  • Consensus sequence: CNGTCCTCCC Submotif: canonical Cell Type: K562 GEO ID: GSE31477

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and Transcription Factor Targets for ZNF263 Gene

Localization for ZNF263 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF263 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF263 Gene COMPARTMENTS Subcellular localization image for ZNF263 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for ZNF263 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with ZNF263: view

Pathways & Interactions for ZNF263 Gene

SuperPathways for ZNF263 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF263: view

Pathways by source for ZNF263 Gene

2 Reactome pathways for ZNF263 Gene

Gene Ontology (GO) - Biological Process for ZNF263 Gene

None

No data available for SIGNOR curated interactions for ZNF263 Gene

Drugs & Compounds for ZNF263 Gene

No Compound Related Data Available

Transcripts for ZNF263 Gene

Unigene Clusters for ZNF263 Gene

Zinc finger protein 263:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF263 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
SP1:
SP2: - - - -
SP3: - -
SP4: - - - - -

Relevant External Links for ZNF263 Gene

GeneLoc Exon Structure for
ZNF263
ECgene alternative splicing isoforms for
ZNF263

Expression for ZNF263 Gene

mRNA expression in normal human tissues for ZNF263 Gene

Protein differential expression in normal tissues from HIPED for ZNF263 Gene

This gene is overexpressed in Nasal epithelium (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF263 Gene



SOURCE GeneReport for Unigene cluster for ZNF263 Gene Hs.611475

mRNA Expression by UniProt/SwissProt for ZNF263 Gene

O14978-ZN263_HUMAN
Tissue specificity: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocyte.
genes like me logo Genes that share expression patterns with ZNF263: view

Protein tissue co-expression partners for ZNF263 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZNF263 Gene

Orthologs for ZNF263 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF263 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF263 35
  • 89.51 (n)
  • 89.31 (a)
ZNF263 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF263 35
  • 90.53 (n)
  • 92.24 (a)
ZNF263 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp263 35
  • 84.74 (n)
  • 84.79 (a)
Zfp263 16
Zfp263 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZNF263 35
  • 99.61 (n)
  • 99.27 (a)
ZNF263 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp263 35
  • 83.33 (n)
  • 82.69 (a)
oppossum
(Monodelphis domestica)
Mammalia ZNF263 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 31 (a)
OneToMany
-- 36
  • 32 (a)
OneToMany
Species with no ortholog for ZNF263:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF263 Gene

ENSEMBL:
Gene Tree for ZNF263 (if available)
TreeFam:
Gene Tree for ZNF263 (if available)

Paralogs for ZNF263 Gene

Paralogs for ZNF263 Gene

(520) SIMAP similar genes for ZNF263 Gene using alignment to 9 proteins:

Pseudogenes.org Pseudogenes for ZNF263 Gene

genes like me logo Genes that share paralogs with ZNF263: view

Variants for ZNF263 Gene

Sequence variations from dbSNP and Humsavar for ZNF263 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs220379 - 3,289,435(+) TGTAT(A/C/G)CTCTG reference, missense
rs34236132 - 3,290,106(-) AATGA(C/T)GAGGT reference, missense
rs57710602 - 3,290,443(+) CAATC(A/G)GATTC reference, missense
rs183388 -- 3,297,367(+) TGGAC(A/C)CCAGT intron-variant
rs183389 -- 3,297,376(+) GTAGT(A/T)CTGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF263 Gene

Variant ID Type Subtype PubMed ID
dgv2583n71 CNV Loss 21882294

Variation tolerance for ZNF263 Gene

Residual Variation Intolerance Score: 44.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.72; 32.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF263 Gene

HapMap Linkage Disequilibrium report
ZNF263

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF263 Gene

Disorders for ZNF263 Gene

Relevant External Links for ZNF263

Human Genome Epidemiology (HuGE) Navigator
ZNF263
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF263

No disorders were found for ZNF263 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF263 Gene

Publications for ZNF263 Gene

  1. Isolation of a cDNA encoding a widely expressed novel zinc finger protein with the LeR and KRAB-A domains. (PMID: 9256059) Yokoyama M. … Fukushima A. (Biochim. Biophys. Acta 1997) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Genomic targets of the KRAB and SCAN domain-containing zinc finger protein 263. (PMID: 19887448) Frietze S. … Farnham P.J. (J. Biol. Chem. 2010) 3
  5. An atlas of combinatorial transcriptional regulation in mouse and man. (PMID: 20211142) Ravasi T. … Hayashizaki Y. (Cell 2010) 3

Products for ZNF263 Gene

Sources for ZNF263 Gene

Content