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Aliases for ZNF260 Gene

Aliases for ZNF260 Gene

  • Zinc Finger Protein 260 2 3
  • Zfp-260 3 4
  • ZFP260 3 4
  • PEX1 3 6
  • OZRF1 3

External Ids for ZNF260 Gene

Summaries for ZNF260 Gene

GeneCards Summary for ZNF260 Gene

ZNF260 (Zinc Finger Protein 260) is a Protein Coding gene. Among its related pathways are Peroxisome. An important paralog of this gene is ZNF146.

UniProtKB/Swiss-Prot for ZNF260 Gene

  • Transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. Binds to PE response elements (PERE) present in the promoter of genes such as ANF/NPPA and acts as a direct transcriptional activator of NPPA. Also acts as a cofactor with GATA4, a key cardiac regulator (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF260 Gene

Genomics for ZNF260 Gene

Genomic Location for ZNF260 Gene

Start:
36,510,687 bp from pter
End:
36,528,660 bp from pter
Size:
17,974 bases
Orientation:
Minus strand

Genomic View for ZNF260 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF260 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF260 Gene

Regulatory Elements for ZNF260 Gene

Proteins for ZNF260 Gene

  • Protein details for ZNF260 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3ZCT1-ZN260_HUMAN
    Recommended name:
    Zinc finger protein 260
    Protein Accession:
    Q3ZCT1
    Secondary Accessions:
    • Q0VF43

    Protein attributes for ZNF260 Gene

    Size:
    412 amino acids
    Molecular mass:
    47222 Da
    Quaternary structure:
    • Binds DNA. Interacts with GATA4 (By similarity).

neXtProt entry for ZNF260 Gene

Proteomics data for ZNF260 Gene at MOPED

Post-translational modifications for ZNF260 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys204 and Lys358

Other Protein References for ZNF260 Gene

No data available for DME Specific Peptides for ZNF260 Gene

Domains for ZNF260 Gene

Gene Families for ZNF260 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF260 Gene

UniProtKB/Swiss-Prot:

ZN260_HUMAN
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.:
    • Q3ZCT1
Similarity:
  • Contains 13 C2H2-type zinc fingers.:
    • Q3ZCT1
genes like me logo Genes that share domains with ZNF260: view

Function for ZNF260 Gene

Molecular function for ZNF260 Gene

UniProtKB/Swiss-Prot Function: Transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. Binds to PE response elements (PERE) present in the promoter of genes such as ANF/NPPA and acts as a direct transcriptional activator of NPPA. Also acts as a cofactor with GATA4, a key cardiac regulator (By similarity).
UniProtKB/Swiss-Prot Induction: Up-regulated by activation of alpha1-adrenergic receptors.

Gene Ontology (GO) - Molecular Function for ZNF260 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IBA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF260: view

Phenotypes for ZNF260 Gene

GenomeRNAi human phenotypes for ZNF260:
genes like me logo Genes that share phenotypes with ZNF260: view

miRNA for ZNF260 Gene

miRTarBase miRNAs that target ZNF260

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF260 Gene

Localization for ZNF260 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF260 Gene

Gene Ontology (GO) - Cellular Components for ZNF260 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with ZNF260: view

Pathways for ZNF260 Gene

SuperPathways for ZNF260 Gene

Superpath Contained pathways
1 Peroxisome
genes like me logo Genes that share pathways with ZNF260: view

Pathways by source for ZNF260 Gene

1 KEGG pathway for ZNF260 Gene

Gene Ontology (GO) - Biological Process for ZNF260 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
GO:0007275 multicellular organismal development IEA --
genes like me logo Genes that share ontologies with ZNF260: view

Transcripts for ZNF260 Gene

Unigene Clusters for ZNF260 Gene

Zinc finger protein 260:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF260 Gene

No ASD Table

Relevant External Links for ZNF260 Gene

GeneLoc Exon Structure for
ZNF260
ECgene alternative splicing isoforms for
ZNF260

Expression for ZNF260 Gene

mRNA expression in normal human tissues for ZNF260 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for ZNF260 Gene Hs.18103

genes like me logo Genes that share expressions with ZNF260: view

Orthologs for ZNF260 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF260 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF260 36
  • 99.6 (n)
  • 100 (a)
ZNF260 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF260 36
  • 91.73 (n)
  • 91.73 (a)
dog
(Canis familiaris)
Mammalia ZNF260 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp260 36
  • 84.36 (n)
  • 86.73 (a)
Zfp260 16
Zfp260 37
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 47 (a)
ManyToMany
-- 37
  • 41 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia LOC102549115 36
  • 83.7 (n)
  • 86.24 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 45 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ZNF146 37
  • 27 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG11398 37
  • 22 (a)
OneToMany
Species with no ortholog for ZNF260:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF260 Gene

ENSEMBL:
Gene Tree for ZNF260 (if available)
TreeFam:
Gene Tree for ZNF260 (if available)

Paralogs for ZNF260 Gene

Paralogs for ZNF260 Gene

Selected SIMAP similar genes for ZNF260 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for ZNF260 Gene

genes like me logo Genes that share paralogs with ZNF260: view

Variants for ZNF260 Gene

Sequence variations from dbSNP and Humsavar for ZNF260 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs2587 -- 36,510,833(+) ACCAT(C/G)ATAAT utr-variant-3-prime
rs2912434 -- 36,516,184(+) AGATT(A/C)TTTAT intron-variant
rs2945968 -- 36,530,318(-) TTTTC(C/T)TTAAG upstream-variant-2KB
rs2945974 -- 36,528,795(+) AGCGG(C/G)TCGGC upstream-variant-2KB
rs2945977 -- 36,512,705(+) TTTTT(A/T)AAAAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF260 Gene

Variant ID Type Subtype PubMed ID
nsv833816 CNV Gain 17160897
nsv911648 CNV Loss 21882294
nsv833817 CNV Loss 17160897

Relevant External Links for ZNF260 Gene

HapMap Linkage Disequilibrium report
ZNF260

Disorders for ZNF260 Gene

No disorders were found for ZNF260 Gene.

No data available for UniProtKB/Swiss-Prot for ZNF260 Gene

Publications for ZNF260 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. The zinc finger-only protein Zfp260 is a novel cardiac regulator and a nuclear effector of alpha1-adrenergic signaling. (PMID: 16166646) Debrus S. … Nemer M. (Mol. Cell. Biol. 2005) 3 4
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3

Products for ZNF260 Gene

Sources for ZNF260 Gene

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