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Aliases for ZNF260 Gene

Aliases for ZNF260 Gene

  • Zinc Finger Protein 260 2 3 5
  • Zfp-260 3 4
  • ZFP260 3 4
  • OZRF1 3
  • PEX1 3

External Ids for ZNF260 Gene

Previous GeneCards Identifiers for ZNF260 Gene

  • GC19M041695
  • GC19M037001
  • GC19M033470
  • GC19M036676
  • GC19M036708
  • GC19M036892

Summaries for ZNF260 Gene

GeneCards Summary for ZNF260 Gene

ZNF260 (Zinc Finger Protein 260) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF146.

UniProtKB/Swiss-Prot for ZNF260 Gene

  • Transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. Binds to PE response elements (PERE) present in the promoter of genes such as ANF/NPPA and acts as a direct transcriptional activator of NPPA. Also acts as a cofactor with GATA4, a key cardiac regulator (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF260 Gene

Genomics for ZNF260 Gene

Regulatory Elements for ZNF260 Gene

Enhancers for ZNF260 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ZNF260 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF260 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF260 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF260 Gene

Chromosome:
19
Start:
36,510,687 bp from pter
End:
36,528,660 bp from pter
Size:
17,974 bases
Orientation:
Minus strand

Genomic View for ZNF260 Gene

Genes around ZNF260 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF260 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF260 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF260 Gene

Proteins for ZNF260 Gene

  • Protein details for ZNF260 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3ZCT1-ZN260_HUMAN
    Recommended name:
    Zinc finger protein 260
    Protein Accession:
    Q3ZCT1
    Secondary Accessions:
    • Q0VF43

    Protein attributes for ZNF260 Gene

    Size:
    412 amino acids
    Molecular mass:
    47222 Da
    Quaternary structure:
    • Binds DNA. Interacts with GATA4 (By similarity).

neXtProt entry for ZNF260 Gene

Post-translational modifications for ZNF260 Gene

  • Ubiquitination at Lys 204
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF260 Gene

No data available for DME Specific Peptides for ZNF260 Gene

Domains & Families for ZNF260 Gene

Gene Families for ZNF260 Gene

Protein Domains for ZNF260 Gene

Suggested Antigen Peptide Sequences for ZNF260 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q3ZCT1

UniProtKB/Swiss-Prot:

ZN260_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 13 C2H2-type zinc fingers.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 13 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF260: view

Function for ZNF260 Gene

Molecular function for ZNF260 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. Binds to PE response elements (PERE) present in the promoter of genes such as ANF/NPPA and acts as a direct transcriptional activator of NPPA. Also acts as a cofactor with GATA4, a key cardiac regulator (By similarity).
UniProtKB/Swiss-Prot Induction:
Up-regulated by activation of alpha1-adrenergic receptors.

Gene Ontology (GO) - Molecular Function for ZNF260 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF260: view

Phenotypes for ZNF260 Gene

genes like me logo Genes that share phenotypes with ZNF260: view

Animal Models for ZNF260 Gene

MGI Knock Outs for ZNF260:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF260 Gene

Localization for ZNF260 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF260 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF260 Gene COMPARTMENTS Subcellular localization image for ZNF260 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for ZNF260 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with ZNF260: view

Pathways & Interactions for ZNF260 Gene

SuperPathways for ZNF260 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF260 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with ZNF260: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF260 Gene

Drugs & Compounds for ZNF260 Gene

No Compound Related Data Available

Transcripts for ZNF260 Gene

Unigene Clusters for ZNF260 Gene

Zinc finger protein 260:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF260 Gene

No ASD Table

Relevant External Links for ZNF260 Gene

GeneLoc Exon Structure for
ZNF260
ECgene alternative splicing isoforms for
ZNF260

Expression for ZNF260 Gene

mRNA expression in normal human tissues for ZNF260 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of ZNF260 Gene:

ZNF260

SOURCE GeneReport for Unigene cluster for ZNF260 Gene:

Hs.18103
genes like me logo Genes that share expression patterns with ZNF260: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ZNF260 Gene

Orthologs for ZNF260 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF260 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF260 34
  • 91.73 (n)
  • 91.73 (a)
mouse
(Mus musculus)
Mammalia Zfp260 34
  • 84.36 (n)
  • 86.73 (a)
Zfp260 16
Zfp260 35
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZNF260 34
  • 99.6 (n)
  • 100 (a)
ZNF260 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC102549115 34
  • 83.7 (n)
  • 86.24 (a)
dog
(Canis familiaris)
Mammalia ZNF260 35
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 47 (a)
ManyToMany
-- 35
  • 41 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 45 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ZNF146 35
  • 27 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG11398 35
  • 22 (a)
OneToMany
Species where no ortholog for ZNF260 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF260 Gene

ENSEMBL:
Gene Tree for ZNF260 (if available)
TreeFam:
Gene Tree for ZNF260 (if available)

Paralogs for ZNF260 Gene

Paralogs for ZNF260 Gene

(501) SIMAP similar genes for ZNF260 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for ZNF260 Gene

genes like me logo Genes that share paralogs with ZNF260: view

Variants for ZNF260 Gene

Sequence variations from dbSNP and Humsavar for ZNF260 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs3111554 -- 36,520,458(+) GATGC(A/G)AACTG intron-variant
rs10577491 -- 36,512,638(+) GTGTT(-/GAT)TTTAT cds-indel
rs11327751 -- 36,520,214(+) GTCTC(-/A)AAAAA intron-variant
rs4561584 -- 36,526,718(+) GTACA(C/T)GTACA intron-variant
rs77992302 -- 36,513,411(+) ATATT(C/T)TATAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF260 Gene

Variant ID Type Subtype PubMed ID
esv3583371 CNV loss 25503493
esv3644261 CNV loss 21293372
esv3644262 CNV loss 21293372
nsv1064851 CNV loss 25217958
nsv833816 CNV gain 17160897
nsv833817 CNV loss 17160897

Variation tolerance for ZNF260 Gene

Residual Variation Intolerance Score: 25.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.26; 25.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF260 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF260

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF260 Gene

Disorders for ZNF260 Gene

Relevant External Links for ZNF260

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF260

No disorders were found for ZNF260 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF260 Gene

Publications for ZNF260 Gene

  1. The zinc finger-only protein Zfp260 is a novel cardiac regulator and a nuclear effector of alpha1-adrenergic signaling. (PMID: 16166646) Debrus S. … Nemer M. (Mol. Cell. Biol. 2005) 3 4 65
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 65
  4. A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. (PMID: 19490893) Luo J. … Elledge S.J. (Cell 2009) 3 65
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3 65

Products for ZNF260 Gene

Sources for ZNF260 Gene

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