ZNF260 Gene
protein-coding GIFtS: 39
GCID: GC19M037001
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zinc finger protein 260
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Aliases
for ZNF260 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 2601 2 | | OZRF12 | | ZFP2602 3 | | PEX12 | | Zfp2601 | | Zfp-2603 | | Ozrf11 | | Zfp-2603 |
Export aliases for ZNF260 gene to outside databasesPrevious GC identifers: GC19M041695 GC19M033470 |
Summaries
for ZNF260 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN260_HUMAN, Q3ZCT1Function: Transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. Bindsto PE response elements (PERE) present in the promoter of genes such as ANF/NPPA and acts as a direct transcriptionalactivator of NPPA. Also acts as a cofactor with GATA4, a key cardiac regulator (By similarity)
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Genomic Views
for ZNF260 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF260 gene promoter:
RREB-1 STAT6 RORalpha2 Egr-2 FAC1 FOXO4 IRF-7A MRF-2 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF260
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF260 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.12 Ensembl cytogenetic band: 19q13.12 HGNC cytogenetic band: 19q13.12ZNF260 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M037001: view genomic region
(about GC identifiers)
Start:
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37,001,589 bp from pter |
End:
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37,019,562 bp from pter |
Size:
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17,974 bases |
Orientation:
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minus strand |
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Proteins
for ZNF260 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN260_HUMAN, Q3ZCT1 (See
protein sequence)Recommended Name: Zinc finger protein 260 Size: 412 amino acids; 47222 Da
Subunit: Binds DNA. Interacts with GATA4 (By similarity)
Subcellular location: Nucleus
Caution: It is uncertain whether Met-1 or Met-4 is the initiator
Secondary accessions: Q0VF43Explore the universe of human proteins at neXtProt for ZNF260: NX_Q3ZCT1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q3ZCT1
ZNF260 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins (4 alternative transcripts):
NP_001012774.1 NP_001159508.1 NP_001159509.1 NP_001159510.1
ENSEMBL proteins: ENSP00000429803 ENSP00000464964 ENSP00000465834 ENSP00000467219
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
ZNF260 for ontologies About GeneDecksing
ZNF260 Antibody Products:
Assay Products for ZNF260: |
Protein
Domains /
Families
for ZNF260 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF260 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q3ZCT1ProtoNet protein and cluster: Q3ZCT1 UniProtKB/Swiss-Prot: ZN260_HUMAN, Q3ZCT1Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 13 C2H2-type zinc fingers |
Function
for ZNF260 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZN260_HUMAN, Q3ZCT1Function: Transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. Bindsto PE response elements (PERE) present in the promoter of genes such as ANF/NPPA and acts as a direct transcriptionalactivator of NPPA. Also acts as a cofactor with GATA4, a key cardiac regulator (By similarity)Induction: Up-regulated by activation of alpha1-adrenergic receptors
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF260 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF260 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for ZNF260 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF260 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF260 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
ZNF260 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ZNF260:
|
Pathways & Interactions
for ZNF260 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF260
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | | GO:0007275 | multicellular organismal development |
IEA | -- |
ZNF260 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF260 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF260
Search CenterWatch for drugs/clinical trials and news about ZNF260 / ZN260
|
Transcripts
for ZNF260 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF260 gene (4 alternative transcripts): NM_001012756.2 NM_001166036.1 NM_001166037.1 NM_001166038.1 Unigene Cluster for ZNF260: Zinc finger protein 260 Hs.18103 [show with all ESTs]Unigene Representative Sequence: NM_0010127565 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000523638(uc002oee.2 uc010eey.2 uc002oef.2 uc002oed.2)
ENST00000592282 ENST00000593142 ENST00000588993 ENST00000520608
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF260 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF260 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 4): ZNF260 (NM_001012756) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF260 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF260 |
Additional cDNA sequence: AK122854.1 AK123830.1 AK291442.1 BC042676.1 BC119003.1 BC122549.1 5 DOTS entries: DT.75106689 DT.91641961 DT.100747915 DT.91653349 DT.40275187 24/54 AceView cDNA sequences (see all 54): BC042676 AL135379 AW615146 BQ938102 BM468373 CR609031 AL699089 AK122854 AL542379 AI632976 CK003113 N56028 AK123830 BF510549 BU428524 AA349973 CD643067 H87767 BQ214366 BG392210 BG533625 BG261407 BU676687 BP431012
GeneLoc Exon Structure
|
Expression
for ZNF260 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF260 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAATCACCAA
About this image
Genevestigator expression for ZNF260
SOURCE GeneReport for Unigene cluster: Hs.18103
SABiosciences Custom PCR Arrays for ZNF260
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF260
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNF260 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF260 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF260 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF260 |
Orthologs
for ZNF260 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ZNF260 gene from 3/7 species (see all 7) About this table
ENSEMBL Gene Tree for ZNF260 (if available)
TreeFam Gene Tree for ZNF260 (if available) |
Paralogs
for ZNF260 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF260 gene
- ZNF1462
18/496 SIMAP similar genes for ZNF260 using alignment to 2 protein entries: ZN260_HUMAN (see all proteins)
(see all similar genes):ZNF146 ZSCAN23 ZSCAN31 DKFZp313M0722 ZNF323 ZNF569
HZF36 ZNF271 DKFZp547L155 DKFZp666C237 HZF30 ZNF132
ZNF16 ZNF232 ZNF420 ZNF436 ZNF470 ZNF471
ZNF260 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ZNF260
PGOHUM00000256689
|
Genomic Variants
for ZNF260 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF260 (37001589 - 37019562 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF260: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for ZNF260 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 ZNF260 for disorders About MalaCards
ZNF260 for disorders About GeneDecksing
OMIM gene information: 613749
OMIM disorders: --
Export disorders for ZNF260 gene to outside databases
|
Publications
for ZNF260 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF260 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF260) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The zinc finger-only protein Zfp260 is a novel cardiac regulator and a nuclear effector of alpha1-adrenergic signaling. (PubMed id 16166646)1, 2 Debrus S.... Nemer M. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening. (PubMed id 7829101)1 Robertson N.G....Morton C.C. (1994)
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External Searches for ZNF260 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF260 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF260 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF260 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF260 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF260 gene:
Search GeneIP for patents involving ZNF260
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF260 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF260 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF260 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF260 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF260 | | OriGene 3'-UTR Clone for ZNF260 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF260 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF260 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF260 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF260 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF260 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF260 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF260 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF260 |
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 | | | ZNF260 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF260 |
|  |  |  | | | | Search ThermoFisher Antibodies for ZNF260 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF260 |
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