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ZNF26 Gene

protein-coding   GIFtS: 45
GCID: GC12P133563

Zinc Finger Protein 26

(Previous name: zinc finger protein 26 (KOX 20))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Zinc Finger Protein 261 2
Zinc Finger Protein KOX202 3
KOX202 3
Zinc Finger Protein 26 (KOX 20)1
HEL-1792
Epididymis Luminal Protein 1792

External Ids:    HGNC: 130531   Entrez Gene: 75742   Ensembl: ENSG000001983937   OMIM: 1945375   UniProtKB: P170313   
ORGUL members:         

Export aliases for ZNF26 gene to outside databases

Previous GC identifers: GC12P131066 GC12P133116 GC12P131825 GC12P131393 GC12P132173 GC12P132073 GC12P130343


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF26 Gene:
ZNF26 (zinc finger protein 26) is a protein-coding gene. An important paralog of this gene is ZNF175.

UniProtKB/Swiss-Prot: ZNF26_HUMAN, P17031
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_024477.15  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF26 gene promoter:
         AhR   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF26 promoter sequence
   Search Chromatin IP Primers for ZNF26

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF26


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.33   Ensembl cytogenetic band:  12q24.33   HGNC cytogenetic band: 12q24.33

ZNF26 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF26 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P133563:  view genomic region     (about GC identifiers)

Start:
133,562,951 bp from pter      End:
133,589,154 bp from pter
Size:
26,204 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZNF26_HUMAN, P17031 (See protein sequence)
Recommended Name: Zinc finger protein 26  
Size: 533 amino acids; 61282 Da
Sequence caution: Sequence=AAH08211.1; Type=Erroneous initiation; Sequence=BAA91367.1; Type=Erroneous initiation;
Secondary accessions: Q86X57 Q9NWL3

Explore the universe of human proteins at neXtProt for ZNF26: NX_P17031

Explore proteomics data for ZNF26 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF26 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001243208.1  NP_001243209.1  NP_062537.2  

    ENSEMBL proteins: 
     ENSP00000443888   ENSP00000333725   ENSP00000445494   ENSP00000437420  
    Reactome Protein details: P17031

    ZNF26 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ZNF26

     
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    antibodies-online proteins for ZNF26 (5 products) 

     
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    antibodies-online antibodies for ZNF26 (3 products) 

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    antibodies-online kits for ZNF26 (3 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry P17031

    ProtoNet protein and cluster: P17031

    1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: ZNF26_HUMAN, P17031
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 13 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    Find genes that share domains with ZNF26           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZNF26_HUMAN, P17031
    Function: May be involved in transcriptional regulation

         Genatlas biochemistry entry for ZNF26:
    zinc finger protein 26 (KOX20) (C2H2 type,Kruppel-like)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IBA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF26           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ZNF26

    miRNA
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    8 qRT-PCR Assays for microRNAs that regulate ZNF26:
    hsa-miR-3164 hsa-miR-607 hsa-miR-875-3p hsa-miR-206 hsa-miR-889 hsa-miR-613 hsa-miR-1 hsa-miR-1299
    SwitchGear 3'UTR luciferase reporter plasmidZNF26 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ZNF26

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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF26

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF26


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZNF26_HUMAN, P17031: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZNF26           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF26 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40


    Find genes that share SuperPaths with ZNF26           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF26
        Generic Transcription Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF26
    Interactions:

        Search GeneGlobe Interaction Network for ZNF26

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IBA--

    Find genes that share ontologies with ZNF26           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF26



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF26 gene (3 alternative transcripts): 
    NM_001256279.1  NM_001256280.1  NM_019591.3  

    Unigene Cluster for ZNF26:

    Zinc finger protein 26
    Hs.489608  [show with all ESTs]
    Unigene Representative Sequence: AK122941
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000537956 ENST00000545101 ENST00000540238 ENST00000328654(uc001ull.1)
    ENST00000544181 ENST00000534834
    miRNA
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    8 qRT-PCR Assays for microRNAs that regulate ZNF26:
    hsa-miR-3164 hsa-miR-607 hsa-miR-875-3p hsa-miR-206 hsa-miR-889 hsa-miR-613 hsa-miR-1 hsa-miR-1299
    SwitchGear 3'UTR luciferase reporter plasmidZNF26 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: ZNF26 (NM_019591)
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    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ZNF26
    OriGene qSTAR qPCR primer pairs in human, mouse for ZNF26
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ZNF26
      QuantiTect SYBR Green Assays in human, mouse, rat ZNF26
      QuantiFast Probe-based Assays in human, mouse, rat ZNF26

    Additional mRNA sequence: 

    AK000762.1 AK122941.1 AK225296.1 AK291243.1 AL833057.1 BC008211.1 BC046206.2 BT006963.1 
    X52351.1 

    9 DOTS entries:

    DT.121213915  DT.99962016  DT.452910  DT.441787  DT.102824653  DT.99944664  DT.121213909  DT.121214192 
    DT.40283062 

    Selected AceView cDNA sequences (see all 50):

    NM_019591 BX089966 AL833057 AK122941 AW339163 AI791872 BC008211 AI002259 
    R55614 BE218108 X52351 AA157811 BI914253 BQ710688 AA291404 R55615 
    AI733471 CB069076 AA906510 BI118124 BU194644 BT006963 AK000762 BC046206 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF26 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACCAGAAAA
    ZNF26 Expression
    About this image

    ZNF26 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF26 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.489608
        Custom PCR Arrays for ZNF26
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF26

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of mammals.

    Orthologs for ZNF26 gene from Selected species (see all 3)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia --
    Uncharacterized protein
    29(a)
    many ↔ many
    X(41032755-41072766)


    ENSEMBL Gene Tree for ZNF26 (if available)
    TreeFam Gene Tree for ZNF26 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF26 gene
    ZNF1752  ZNF6742  ZNF4872  ZNF5102  ZIM32  ZNF6142  ZNF1572  ZNF6132  
    ZNF812  ZNF6492  ENSG000002673602  ZNF7822  ZNF7932  ZNF252  ZNF5682  ENSG000002365752  
    ENSG000002296312  ZNF5672  ZNF1822  ZNF37A2  ZNF2482  ZNF3002  ZNF3822  RBAK-RBAKDN2  
    Selected SIMAP similar genes for ZNF26 using alignment to 4 protein entries:     ZNF26_HUMAN (see all proteins) (see all similar genes):
    DKFZp666M039    ZNF83    ZNF649    ZNF415    ZFS-4    ZNF818P
    ZNF616    ZNF350    DKFZp313M0722    ZNF323    ZNF717    ZNF229
    ZNF282    ZNF55    ZNF624    ZNF208    ZNF614    ZNF506

    Find genes that share paralogs with ZNF26           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF26 (see all 238)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1145814801,2
    C--133561084(+) ATGACC/TATTTC 3 -- us2k10--------
    rs1140570171,2
    C--133561185(+) CTCTCA/GCAAAT 3 -- us2k10--------
    rs1140440431,2
    C--133561577(+) CAAGAA/GTGTAC 3 -- us2k10--------
    rs1147086191,2
    C--133562192(+) CACATC/TTTAGC 3 -- us2k10--------
    rs1178179581,2
    C--133562284(+) ATCATA/TTGAAC 3 -- us2k10--------
    rs3767244431,2
    C--133562821(-) CTAGAA/GAGGGG 3 -- us2k10--------
    rs1158586421,2
    C--133563254(+) CGGTCC/TGTGTT 3 -- ut510--------
    rs2006358841,2
    C--133563333(+) CTGGTC/GCCGCA 3 -- ut510--------
    rs1419144661,2
    C--133563372(+) GGTCT-/CTCCGC 3 -- ut510--------
    rs1143819471,2
    C--133563925(+) GGTGGA/GGAGGG 3 -- int10--------

    HapMap Linkage Disequilibrium report for ZNF26 (133562951 - 133589154 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for ZNF26:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv330e199CNV Deletion23128226
    nsv438246CNV Loss16468122
    dgv219n27CNV Gain19166990
    nsv899834CNV Gain21882294
    nsv455813CNV Gain19166990
    nsv470336CNV Gain18288195
    nsv525745CNV Gain19592680
    dgv538e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF26
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF26

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 194537    OMIM disorders: --


    Find genes that share disorders with ZNF26           About GenesLikeMe


    Export disorders for ZNF26 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF26 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF26)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Multiple genes encoding zinc finger domains are expressed in human T cells. (PubMed id 2288909)1, 2 Thiesen H.-J. (New Biol. 1990)
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    5. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (Nature 2006)
    6. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (Nat. Biotechnol. 2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    8. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)
    9. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (Gene 1994)
    10. Two human genes encoding zinc finger proteins, ZNF 12 (KOX 3) and ZNF 26 (KOX 20), map to chromosome 7p22-p21 and 12q24.33, respectively. (PubMed id 2026422)1 Seite P....Thiesen H.J. (Hum. Genet. 1991)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7574 HGNC: 13053 AceView: ZNF26 Ensembl:ENSG00000198393 euGenes: HUgn7574
    ECgene: ZNF26 H-InvDB: ZNF26

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF26 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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