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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF26 Gene

protein-coding   GIFtS: 44
GCID: GC12P133563

Zinc Finger Protein 26

(Previous name: zinc finger protein 26 (KOX 20))
  Search for ZNF26
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 261 2
Zinc Finger Protein KOX202 3
KOX202 3
Zinc Finger Protein 26 (KOX 20)1

External Ids:    HGNC: 130531   Entrez Gene: 75742   Ensembl: ENSG000001983937   OMIM: 1945375   UniProtKB: P170313   

Export aliases for ZNF26 gene to outside databases

Previous GC identifers: GC12P131066 GC12P133116 GC12P131825 GC12P131393 GC12P132173 GC12P132073 GC12P130343


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF26 Gene: 
ZNF26 (zinc finger protein 26) is a protein-coding gene. Among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF334.

UniProtKB/Swiss-Prot: ZNF26_HUMAN, P17031
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_024477.14  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF26 gene promoter:
         AhR   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF26 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF26

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF26


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.33   Ensembl cytogenetic band:  12q24.33   HGNC cytogenetic band: 12q24.33

ZNF26 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF26 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P133563:  view genomic region     (about GC identifiers)

Start:
133,562,951 bp from pter      End:
133,589,154 bp from pter
Size:
26,204 bases      Orientation:
plus strand

0 alternative location:

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZNF26_HUMAN, P17031 (See protein sequence)
Recommended Name: Zinc finger protein 26  
Size: 533 amino acids; 61282 Da
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=AAH08211.1; Type=Erroneous initiation; Sequence=BAA91367.1; Type=Erroneous initiation;
Secondary accessions: Q86X57 Q9NWL3

Explore the universe of human proteins at neXtProt for ZNF26: NX_P17031

Explore proteomics data for ZNF26 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P17031

  • ZNF26 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF26 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001243208.1  NP_001243209.1  NP_062537.2  

    ENSEMBL proteins: 
     ENSP00000443888   ENSP00000333725   ENSP00000445494   ENSP00000437420  
    Reactome Protein details: P17031
    Human Recombinant Protein Products for ZNF26: 
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    Novus Biologicals ZNF26 Lysate
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZNF26 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF26 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry P17031

    ProtoNet protein and cluster: P17031

    1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: ZNF26_HUMAN, P17031
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 13 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF26 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZNF26_HUMAN, P17031
    Function: May be involved in transcriptional regulation

         Genatlas biochemistry entry for ZNF26:
    zinc finger protein 26 (KOX20) (C2H2 type,Kruppel-like)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF26 for ontologies           About GeneDecksing


    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidZNF26 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF26 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF26
        Generic Transcription Pathway
    Gene Expression



    ZNF26 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF26

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF26 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF26

    Search CenterWatch for drugs/clinical trials and news about ZNF26

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF26 gene (3 alternative transcripts): 
    NM_001256279.1  NM_001256280.1  NM_019591.3  

    Unigene Cluster for ZNF26:

    Zinc finger protein 26
    Hs.489608  [show with all ESTs]
    Unigene Representative Sequence: AK122941
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000537956 ENST00000545101 ENST00000540238 ENST00000328654(uc001ull.1)
    ENST00000544181 ENST00000534834
    miRNA
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    8 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNF26:
    hsa-miR-3164 hsa-miR-607 hsa-miR-875-3p hsa-miR-206 hsa-miR-889 hsa-miR-613 hsa-miR-1 hsa-miR-1299
    SwitchGear 3'UTR luciferase reporter plasmidZNF26 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF26
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF26
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF26

    Additional mRNA sequence: 

    AK000762.1 AK122941.1 AK225296.1 AK291243.1 AL833057.1 BC008211.1 BC046206.2 BT006963.1 
    X52351.1 

    9 DOTS entries:

    DT.121213915  DT.99962016  DT.452910  DT.441787  DT.102824653  DT.99944664  DT.121213909  DT.121214192 
    DT.40283062 

    24/50 AceView cDNA sequences (see all 50):

    AI002259 BC008211 AK122941 AI791872 NM_019591 AL833057 R55614 BX089966 
    AW339163 AK000762 BI914253 AI733471 BQ027811 AI636163 AA157811 BG400511 
    BU194644 BQ441148 AA976061 R55615 R97944 AW168597 AW515397 AA604739 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF26 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACCAGAAAA
    ZNF26 Expression
    About this image


    See ZNF26 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF26

    SOURCE GeneReport for Unigene cluster: Hs.489608
        SABiosciences Custom PCR Arrays for ZNF26
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF26

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and chimp.

    Orthologs for ZNF26 gene from 1 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chimpanzee
    (Pan troglodytes)
    Mammalia ZNF261 zinc finger protein 26 99.69(n)
    99.62(a)
      467169  XM_001140744.3  XP_001140744.2 


    ENSEMBL Gene Tree for ZNF26 (if available)
    TreeFam Gene Tree for ZNF26 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF26 gene
    ZNF3342  ZNF1752  ZNF6742  ZNF4872  ZNF5102  LOC1002875152  ZNF6142  RBAK2  
    ZNF6132  ZNF812  ZNF6492  KRBOX42  ZNF33B2  ENSG000002673602  ZNF7822  ZNF122  
    ENSG000002296312  ZNF5672  ZNF1822  ZNF37A2  ZNF2482  ZNF3002  ZNF3822  
    18/541 SIMAP similar genes for ZNF26 using alignment to 4 protein entries:     ZNF26_HUMAN (see all proteins) (see all similar genes):
    DKFZp666M039    ZNF83    ZNF649    ZNF415    ZFS-4    ZNF818P
    ZNF616    ZNF350    DKFZp313M0722    ZNF323    ZNF717    ZNF229
    ZNF282    ZNF55    ZNF624    ZNF208    ZNF614    ZNF506

    ZNF26 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/238 SNPs in ZNF26 are shown (see all 238)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1145814801,2
    C--133561084(+) ATGACC/TATTTC 3 -- us2k10--------
    rs1140570171,2
    C--133561185(+) CTCTCA/GCAAAT 3 -- us2k10--------
    rs1140440431,2
    C--133561577(+) CAAGAA/GTGTAC 3 -- us2k10--------
    rs1147086191,2
    C--133562192(+) CACATC/TTTAGC 3 -- us2k10--------
    rs1178179581,2
    C--133562284(+) ATCATA/TTGAAC 3 -- us2k10--------
    rs3767244431,2
    C--133562821(-) CTAGAA/GAGGGG 3 -- us2k10--------
    rs1158586421,2
    C--133563254(+) CGGTCC/TGTGTT 3 -- ut510--------
    rs2006358841,2
    C--133563333(+) CTGGTC/GCCGCA 3 -- ut510--------
    rs1419144661,2
    C--133563372(+) GGTCT-/CTCCGC 3 -- ut510--------
    rs1143819471,2
    C--133563925(+) GGTGGA/GGAGGG 3 -- int10--------

    HapMap Linkage Disequilibrium report for ZNF26 (133562951 - 133589154 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for ZNF26:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv330e199CNV Deletion23128226
    nsv438246CNV Loss16468122
    dgv219n27CNV Gain19166990
    nsv899834CNV Gain21882294
    nsv455813CNV Gain19166990
    nsv470336CNV Gain18288195
    nsv525745CNV Gain19592680
    dgv538e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZNF26 for disorders           About MalaCards
    OMIM gene information: 194537    OMIM disorders: --


    ZNF26 for disorders           About GeneDecksing


    Export disorders for ZNF26 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF26 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF26)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Multiple genes encoding zinc finger domains are expressed in human T cells. (PubMed id 2288909)1, 2 Thiesen H.-J. (1990)
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    5. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (2006)
    6. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    8. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
    9. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)
    10. Two human genes encoding zinc finger proteins, ZNF 12 (KOX 3) and ZNF 26 (KOX 20), map to chromosome 7p22-p21 and 12q24.33, respectively. (PubMed id 2026422)1 Seite P....Thiesen H.J. (1991)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7574 HGNC: 13053 AceView: ZNF26 Ensembl:ENSG00000198393 euGenes: HUgn7574
    ECgene: ZNF26 H-InvDB: ZNF26

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF26 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF26 gene:
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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