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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF259 Gene

protein-coding   GIFtS: 60
GCID: GC11M116648

zinc finger protein 259
 Explore 8 diseases affiliated with
ZNF259 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ZNF259    

Aliases
for ZNF259 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Zinc Finger Protein 2591 2 3
ZPR11 2 3
Zinc Finger Protein ZPR12

External Ids:    HGNC: 130511   Entrez Gene: 88822   Ensembl: ENSG000001099177   OMIM: 6039015   UniProtKB: O753123   

Export aliases for ZNF259 gene to outside databases

Previous GC identifers: GC11M119002 GC11M118161 GC11M116682 GC11M116186 GC11M116154 GC11M112581


Summaries
for ZNF259 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: ZPR1_HUMAN, O75312
Function: May be a signaling molecule that communicates mitogenic signals from the cytoplasm to the nucleus

Gene Wiki entry for ZNF259


Genomic Views
for ZNF259 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_033899.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF259 gene promoter:
         PPAR-alpha   PPAR-gamma1   HNF-4alpha2   PPAR-gamma2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZNF259 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF259

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF259


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.3   Ensembl cytogenetic band:  11q23.3   HGNC cytogenetic band: 11q23.3

ZNF259 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF259 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M116648:  view genomic region     (about GC identifiers)

Start:
 116,648,436 bp from pter      End:
 116,658,766 bp from pter
Size:
 10,331 bases      Orientation:
 minus strand

Proteins
for ZNF259 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ZPR1_HUMAN, O75312 (See protein sequence)
Recommended Name: Zinc finger protein ZPR1  
Size: 459 amino acids; 50925 Da
Subunit: Binds to the EGF and PDGF receptors. Binds to the elongation factor 1-alpha EF1A (By similarity). Component of
an import snRNP complex composed of KPNB1, SNUPN, SMN1 and ZNF259
Subcellular location: Cytoplasm. Nucleus, nucleolus. Note=Translocates to the nucleolus after treatment with mitogens
Secondary accessions: Q2TAA0

Explore the universe of human proteins at neXtProt for ZNF259: NX_O75312

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O75312

    • ZNF259 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003895.1  
    ENSEMBL proteins: 
     ENSP00000394495   ENSP00000390391   ENSP00000227322   ENSP00000415505   ENSP00000391077  
     ENSP00000410141  

    Human Recombinant Protein Products: 
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    OriGene Purified Protein: ZNF259
    OriGene Protein Over-expression Lysate: ZNF259
    OriGene Custom Protein Services for ZNF259 
    GenScript Custom Purified and Recombinant Proteins Services for ZNF259
    Novus Biologicals ZNF259 Proteins
    Novus Biologicals ZNF259 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ZNF259

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS8650580
    GO:0005730nucleolus IEA--
    GO:0005737cytoplasm IEA--


    ZNF259 for ontologies           About GeneDecksing



    ZNF259 Antibody Products: 
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    Uscn ELISAs and CLIAs for ZNF259

    Protein Domains /
    Families
    for ZNF259 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ZNF259 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR004457 Znf_ZPR1

    Graphical View of Domain Structure for InterPro Entry O75312

    ProtoNet protein and cluster: O75312

    1 Blocks protein family: IPB004457 Zn-finger

    UniProtKB/Swiss-Prot: ZPR1_HUMAN, O75312
    Similarity: Belongs to the ZPR1 family


    Function
    for ZNF259 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ZPR1_HUMAN, O75312
    Function: May be a signaling molecule that communicates mitogenic signals from the cytoplasm to the nucleus

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZNF259
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    SwitchGear 3'UTR luciferase reporter plasmid: ZNF259 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF259 (see all 7)
    OriGene shRNA RFP: ZNF259
    OriGene siRNA: ZNF259
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF259

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ZNF259

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF259 (see all 3)
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    GenScript: all cDNA clones in your preferred vector: ZNF259 (NM_003904)
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZNF259
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF259 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for ZNF259
    Search LifeMap BioReagents cell lines for ZNF259

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for ZNF259

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--


    ZNF259 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ZNF259:
     Synthetic lethal with Ras 

    Animal Models:
         Mouse knock-out Zfp259tm1Rjd for ZNF259
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Zfp259):
     cellular  embryogenesis  mortality/aging 

    ZNF259 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ZNF259 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1EGFR1 Signaling Pathway
    		EGFR1 Signaling Pathway1.00
    2Translational Control
    		Translational Control1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for ZNF259
        Translational Control

    1 BioSystems Pathway for ZNF259 
        EGFR1 Signaling Pathway



    ZNF259 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZNF259

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/36 Interacting proteins for ZNF259 (O753122, 3 ENSP000002273224) via UniProtKB, MINT, STRING, and/or I2D (see all 36)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDK5RAP2Q96SN82, 3MINT-65250 I2D: score=5 
    SMARCB1Q128243, ENSP000002631214I2D: score=4 STRING: ENSP00000263121
    EEF1A1P681043, ENSP000003300544I2D: score=11 STRING: ENSP00000330054
    RBX1P628773, ENSP000002162254I2D: score=10 STRING: ENSP00000216225
    SNUPNO951493, ENSP000003098314I2D: score=1 STRING: ENSP00000309831
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS8650580
    GO:0008283cell proliferation TAS9763455


    ZNF259 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ZNF259 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ZNF259 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF259
    1 Novoseek chemical compound relationship for ZNF259 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 55.5 8 9763455 (2), 17068332 (2), 19966453 (2), 8650580 (1) (see all 5)

    Search CenterWatch for drugs/clinical trials and news about ZNF259 / ZPR1 

    Transcripts
    for ZNF259 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ZNF259 gene: 
    NM_003904.3  

    Unigene Cluster for ZNF259:

    Zinc finger protein 259
    Hs.7165  [show with all ESTs]
    Unigene Representative Sequence: BC111028
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000429220 ENST00000444935 ENST00000227322(uc001ppp.3) ENST00000449430
    ENST00000431973 ENST00000425791 ENST00000498065 ENST00000487030

    miRNA
    Products:             		 OriGene 3'-UTR Clone: ZNF259
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZNF259
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ZNF259
    SwitchGear 3'UTR luciferase reporter plasmid: ZNF259 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF259 (see all 7)
    OriGene shRNA RFP: ZNF259
    OriGene siRNA: ZNF259
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF259
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF259 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF259 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ZNF259 (NM_003904)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZNF259
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF259 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF259
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNF259
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF259
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF259

    Additional cDNA sequence: 

    AF019767.1 AK301227.1 BC004256.1 BC011929.2 BC012162.1 BC017349.2 BC017380.2 BC111028.1 
    BT006642.1 

    11 DOTS entries:

    DT.411006  DT.100757686  DT.95340942  DT.100818718  DT.120746536  DT.120746555  DT.75172205  DT.86852865 
    DT.95340939  DT.121328635  DT.97847038 

    24/288 AceView cDNA sequences (see all 288):

    BQ718326 AI650327 CB148717 BQ649554 AW006230 BQ643553 BQ651494 AI475000 
    BQ674372 BQ945398 BU521186 BQ649624 AW594693 BM910418 BQ641510 BM703850 
    BC012162 CD359945 CR626297 BU623976 CR621542 AI198393 BC011929 BQ671401 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF259    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
    SP1:                                                                                                
    SP2:        -                                                                                       
    SP3:                                                                                                


    ECgene alternative splicing isoforms for ZNF259

    Expression
    for ZNF259 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF259 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTGGGGAGGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ZNF259 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartRight VentricleHeart
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ZNF259 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF259

    SOURCE GeneReport for Unigene cluster: Hs.7165
        SABiosciences Custom PCR Arrays for ZNF259
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF259
    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for ZNF259

    Orthologs
    for ZNF259 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ZNF259 gene from 10/36 species (see all 36)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Zfp2591 , 5 zinc finger protein 2591, 5 87.15(n)1
    90.41(a)1    		   9 (25.38 cM)5
    226871  NM_011752.21  NP_035882.11 
     462730645 
    chicken
    (Gallus gallus)    		 Aves ZNF2591 zinc finger protein 259 74.2(n)
    77.17(a)    		   428256  XM_003642595.1  XP_003642643.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ZNF2596
    		 --
    		 71(a)
    		 1 ↔ 1
    		 GL343949.1(74516-83300)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.66332 Xenopus laevis transcribed sequence with weak similarity more 78.46(n)    48047047 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufc17g092 Danio rerio mRNA similar to zinc finger protein 259 more 76.62(n)    BC052111.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Zpr11 , 3 transcription from Pol I promoter3
    CG9060-PA1    		 48(a)3
    56.36(n)1
    50.7(a)1    		   8D83
    318511  NM_132304.21  NP_572532.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea W03F9.13
    CELE_W03F9.11    		 Protein W03F9.11 40(a)3
    50.51(n)1
    41.81(a)1    		   V(124206-126477)3
    1891621  NM_070737.21  NP_503138.11 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes ZPR1(YGR211W)4
    ZPR11    		 Essential protein with two zinc fingers, present in more4
    Zpr1p1    		 53.79(n)1
    50.61(a)1    		   7(915241-916701)4
    8531251, 4  NP_011727.31  NP_011727.14 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT5G224801 ZPR1 zinc-finger domain protein 53.48(n)
    45.21(a)    		   832309  NM_122153.4  NP_197640.1 
    rice
    (Oryza sativa)    		 Liliopsida Os.271082 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 69.61(n)    AK069434.1 


    ENSEMBL Gene Tree for ZNF259 (if available)
    TreeFam Gene Tree for ZNF259 (if available) 

    Paralogs
    for ZNF259 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF259 gene

    ZNF259 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ZNF259
    PGOHUM00000243320


    Genomic Variants
    for ZNF259 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/227 NCBI SNPs in ZNF259 are shown (see all 227)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs764635241,2
    		--112592532(+) AATCAC/TCCACA 2 -- ut310--------
    rs1146271221,2
    		C,F,--112592665(+) GAGTCG/ACAGGA 2 -- ut311Minor allele frequency- A:0.03WA 118
    rs454595071,2
    		F--112592692(+) GACAGC/TAGCCC 2 -- ut311Minor allele frequency- T:0.17NS 40
    rs782965221,2
    		C,F,--116648776(+) TCCTCC/ATCAGC 1 -- int12Minor allele frequency- A:0.07NA EA 240
    rs1387330821,2
    		--116648802(+) AATTAC/TCACCT 1 -- int10--------
    rs1427319941,2
    		--116648851(+) CACAAC/TCCAGC 1 -- int10--------
    rs6411691,2
    		C,F,H,--116648900(+) CCATCT/CGATGT 1 -- int1 ese34Minor allele frequency- C:0.01NS EA 410
    rs1394294541,2
    		--116648911(+) ACTGTC/TTTCCT 1 -- int10--------
    rs9641841,2
    		C,F,O,H,--116648917(+) TTCCTC/GATCTG 1 -- int1 ese331Minor allele frequency- G:0.24NS EA MN NA WA CSA 2742
    rs1117325541,2
    		C,--116649131(+) ACAAGG/CATAGG 1 -- int12Minor allele frequency- C:0.03NA 122

    HapMap Linkage Disequilibrium report for ZNF259 (116648436 - 116658766 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for ZNF259
         1 CNV: 34918

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF259
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF259

    Disorders / Diseases
    for ZNF259 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ZNF259 for disorders           About GeneDecksing

    OMIM gene information: 603901    OMIM disorders: --

    8 diseases for ZNF259:    About MalaCards
    spinal muscular atrophy    muscular atrophy    gigantism    hypertriglyceridemia
    neurodegeneration    cholesterol    malaria    neuronitis

    1 disease from the University of Copenhagen DISEASES database for ZNF259:
    Muscular atrophy
    Human Genome Epidemiology (HuGE) Navigator: ZNF259 (7 documents)

    Export disorders for ZNF259 gene to outside databases

    Publications
    for ZNF259 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF259 gene, integrated from 9 sources (see all 43):
    (articles sorted by number of sources associating them with ZNF259)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The cytoplasmic zinc finger protein ZPR1 accumulates in the nucleolus of proliferating cells. (PubMed id 9763455)1, 2, 3, 9 Galcheva-Gargova Z.... Davis R.J. (1998)
    2. Binding of zinc finger protein ZPR1 to the epidermal growth factor receptor. (PubMed id 8650580)1, 3, 9 Galcheva-Gargova Z....Davis R.J. (1996)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. SMN, the spinal muscular atrophy protein, forms a pre-import snRNP complex with snurportin1 and importin beta. (PubMed id 12095920)1, 2 Narayanan U.... Matera A.G. (2002)
    5. Interaction of ZPR1 with translation elongation factor-1alpha in proliferating cells. (PubMed id 9852145)1, 2 Gangwani L.... Davis R.J. (1998)
    6. Deficiency of the zinc finger protein ZPR1 causes defects in transcription and cell cycle progression. (PubMed id 17068332)1, 9 Gangwani L. (2006)
    7. Genome-wide screen for metabolic syndrome susceptibili ty Loci reveals strong lipid gene contribution but no evidence for common geneti c basis for clustering of metabolic syndrome traits. (PubMed id 22399527)1 Kristiansson K....Salomaa V. (2012)
    8. Eight genetic loci associated with variation in lipopr otein-associated phospholipase A2 mass and activity and coronary heart disease: meta-analysis of genome-wide association studies from five community-based studi es. (PubMed id 22003152)1 Grallert H....Ballantyne C.M. (2012)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. Novel Loci for metabolic networks and multi-tissue exp ression studies reveal genes for atherosclerosis. (PubMed id 22916037)1 Inouye M....de Bakker P.I. (2012)

    External Searches for ZNF259 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing ZNF259 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8882 HGNC: 13051 AceView: ZNF259andAPOA5 Ensembl:ENSG00000109917 euGenes: HUgn8882
    ECgene: ZNF259 H-InvDB: ZNF259

    Other Databases showing ZNF259 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ZNF259 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF259 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ZNF259 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ZNF259 gene:
    Search GeneIP for patents involving ZNF259

    GeneCards and IP:
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