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Aliases for ZNF257 Gene

Aliases for ZNF257 Gene

  • Zinc Finger Protein 257 2 3 5
  • Bone Marrow Zinc Finger 4 3 4
  • BMZF-4 3 4
  • BMZF4 3 4

External Ids for ZNF257 Gene

Previous GeneCards Identifiers for ZNF257 Gene

  • GC19P022683
  • GC19P022564
  • GC19P022011
  • GC19P022235
  • GC19P021773

Summaries for ZNF257 Gene

GeneCards Summary for ZNF257 Gene

ZNF257 (Zinc Finger Protein 257) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF85.

UniProtKB/Swiss-Prot for ZNF257 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF257 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF257 Gene

Genomics for ZNF257 Gene

Regulatory Elements for ZNF257 Gene

Enhancers for ZNF257 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H022051 0.7 ENCODE 16.8 +4.3 4315 1.2 TBP GTF2F1 PKNOX1 ATF1 SIN3A CC2D1A POLR2A NFYB FOS CREM ZNF257 BNIP3P29 ZNF208 PIR50216 ENSG00000269199
GH19H022429 0.3 FANTOM5 2.3 +379.5 379471 0.3 ZNF208 ZNF98 ZNF257 ZNF492 ZNF676 GC19M022427 ENSG00000269796
GH19H022541 0.3 FANTOM5 1.7 +493.8 493803 0.2 ZNF98 ZNF257 ZNF492 GC19M022543 LINC01233
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF257 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ZNF257 Gene

Genomic Locations for ZNF257 Gene
43,349 bases
Plus strand

Genomic View for ZNF257 Gene

Genes around ZNF257 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF257 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF257 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF257 Gene

Proteins for ZNF257 Gene

  • Protein details for ZNF257 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 257
    Protein Accession:
    Secondary Accessions:
    • B3KPS4
    • E9PG34
    • Q8NE34

    Protein attributes for ZNF257 Gene

    563 amino acids
    Molecular mass:
    65779 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF257 Gene


neXtProt entry for ZNF257 Gene

Post-translational modifications for ZNF257 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF257 Gene

Domains & Families for ZNF257 Gene

Gene Families for ZNF257 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF257 Gene

Suggested Antigen Peptide Sequences for ZNF257 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF257: view

Function for ZNF257 Gene

Molecular function for ZNF257 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF257 Gene

Gene Ontology (GO) - Molecular Function for ZNF257 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0008270 zinc ion binding NAS 10585455
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF257: view
genes like me logo Genes that share phenotypes with ZNF257: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF257 Gene

Localization for ZNF257 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF257 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF257 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF257 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF257: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF257 Gene

Pathways & Interactions for ZNF257 Gene

SuperPathways for ZNF257 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF257: view

Pathways by source for ZNF257 Gene

2 Reactome pathways for ZNF257 Gene

Gene Ontology (GO) - Biological Process for ZNF257 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS,IEA 10585455
genes like me logo Genes that share ontologies with ZNF257: view

No data available for SIGNOR curated interactions for ZNF257 Gene

Drugs & Compounds for ZNF257 Gene

No Compound Related Data Available

Transcripts for ZNF257 Gene

Unigene Clusters for ZNF257 Gene

Zinc finger protein 257:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF257 Gene

No ASD Table

Relevant External Links for ZNF257 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF257 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF257 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF257 Gene:


SOURCE GeneReport for Unigene cluster for ZNF257 Gene:


Evidence on tissue expression from TISSUES for ZNF257 Gene

  • Bone marrow(4)
genes like me logo Genes that share expression patterns with ZNF257: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF257 Gene

Orthologs for ZNF257 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF257 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF257 34
  • 99 (a)
(Bos Taurus)
Mammalia -- 34
  • 54 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 52 (a)
-- 34
  • 41 (a)
(Mus musculus)
Mammalia Zfp429 34
  • 43 (a)
(Canis familiaris)
Mammalia -- 34
  • 40 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 55 (a)
-- 34
  • 43 (a)
-- 34
  • 41 (a)
-- 34
  • 37 (a)
-- 34
  • 33 (a)
-- 34
  • 33 (a)
-- 34
  • 33 (a)
-- 34
  • 30 (a)
Species where no ortholog for ZNF257 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF257 Gene

Gene Tree for ZNF257 (if available)
Gene Tree for ZNF257 (if available)

Paralogs for ZNF257 Gene

(522) SIMAP similar genes for ZNF257 Gene using alignment to 5 proteins: Pseudogenes for ZNF257 Gene

genes like me logo Genes that share paralogs with ZNF257: view

Variants for ZNF257 Gene

Sequence variations from dbSNP and Humsavar for ZNF257 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000035476 -- 22,057,081(+) TGTTA(C/T)CTCCT intron-variant
rs1000192239 -- 22,072,208(+) ACAAA(-/T)TTTTT intron-variant
rs1000214219 -- 22,062,103(+) CTGCC(C/T)AGGCT intron-variant
rs1000214389 -- 22,081,648(+) TTCAG(C/T)CTCTC intron-variant
rs1000401714 -- 22,066,230(+) CTTGG(A/G)GTGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF257 Gene

Variant ID Type Subtype PubMed ID
nsv961196 CNV duplication 23825009
nsv833785 CNV gain 17160897
nsv7306 OTHER inversion 18451855
nsv578973 CNV loss 21841781
nsv578972 CNV loss 21841781
nsv525240 CNV gain 19592680
nsv520741 CNV loss 19592680
nsv470135 CNV loss 18288195
nsv469674 CNV loss 16826518
nsv436857 CNV insertion 17901297
nsv436853 CNV insertion 17901297
nsv436253 CNV deletion 17901297
nsv1112317 CNV deletion 24896259
nsv1063392 CNV loss 25217958
nsv1063115 CNV gain 25217958
nsv1061327 CNV gain 25217958
nsv1055550 CNV loss 25217958
esv4924 OTHER complex 18987735
esv3893183 CNV gain 25118596
esv3643941 CNV loss 21293372
esv3583307 CNV loss 25503493
esv34340 CNV loss 17911159
esv3352646 CNV insertion 20981092
esv2758750 CNV gain+loss 17122850
esv2718335 CNV deletion 23290073
dgv70e203 CNV loss 21179565
dgv633e199 CNV deletion 23128226
dgv513e201 CNV deletion 23290073
dgv512e201 CNV deletion 23290073
dgv511e201 CNV deletion 23290073
dgv3472n100 CNV loss 25217958
dgv3471n100 CNV gain 25217958

Variation tolerance for ZNF257 Gene

Residual Variation Intolerance Score: 91.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.21; 52.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF257 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF257 Gene

Disorders for ZNF257 Gene

Relevant External Links for ZNF257

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF257 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF257 Gene

Publications for ZNF257 Gene

  1. Molecular cloning of six novel Krüppel-like zinc finger genes from hematopoietic cells and identification of a novel transregulatory domain KRNB. (PMID: 10585455) Han ZG … Chen Z (The Journal of biological chemistry 1999) 2 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert JP … Gingras AC (Journal of proteomics 2015) 3 60
  4. Functional Impact and Evolution of a Novel Human Polymorphic Inversion That Disrupts a Gene and Creates a Fusion Transcript. (PMID: 26427027) Puig M … Cáceres M (PLoS genetics 2015) 3 60
  5. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PMID: 17903299) Kathiresan S … Cupples LA (BMC medical genetics 2007) 45 60

Products for ZNF257 Gene

Sources for ZNF257 Gene

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