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Aliases for ZNF257 Gene

Aliases for ZNF257 Gene

  • Zinc Finger Protein 257 2 3 5
  • Bone Marrow Zinc Finger 4 3 4
  • BMZF-4 3 4
  • BMZF4 3 4

External Ids for ZNF257 Gene

Previous GeneCards Identifiers for ZNF257 Gene

  • GC19P022683
  • GC19P022564
  • GC19P022011
  • GC19P022235
  • GC19P021773

Summaries for ZNF257 Gene

GeneCards Summary for ZNF257 Gene

ZNF257 (Zinc Finger Protein 257) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF718.

UniProtKB/Swiss-Prot for ZNF257 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF257 Gene

Genomics for ZNF257 Gene

Regulatory Elements for ZNF257 Gene

Enhancers for ZNF257 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF257 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF257 Gene

22,048,132 bp from pter
22,091,480 bp from pter
43,349 bases
Plus strand

Genomic View for ZNF257 Gene

Genes around ZNF257 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF257 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF257 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF257 Gene

Proteins for ZNF257 Gene

  • Protein details for ZNF257 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 257
    Protein Accession:
    Secondary Accessions:
    • B3KPS4
    • E9PG34
    • Q8NE34

    Protein attributes for ZNF257 Gene

    563 amino acids
    Molecular mass:
    65779 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF257 Gene


neXtProt entry for ZNF257 Gene

Proteomics data for ZNF257 Gene at MOPED

Post-translational modifications for ZNF257 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for ZNF257

No data available for DME Specific Peptides for ZNF257 Gene

Domains & Families for ZNF257 Gene

Gene Families for ZNF257 Gene

Protein Domains for ZNF257 Gene

Suggested Antigen Peptide Sequences for ZNF257 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 13 C2H2-type zinc fingers.
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 13 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF257: view

Function for ZNF257 Gene

Molecular function for ZNF257 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF257: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF257 Gene

Localization for ZNF257 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF257 Gene

Subcellular locations from

Jensen Localization Image for ZNF257 Gene COMPARTMENTS Subcellular localization image for ZNF257 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF257 Gene

Pathways & Interactions for ZNF257 Gene

SuperPathways for ZNF257 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF257: view

Pathways by source for ZNF257 Gene

2 Reactome pathways for ZNF257 Gene

Interacting Proteins for ZNF257 Gene

Gene Ontology (GO) - Biological Process for ZNF257 Gene


No data available for SIGNOR curated interactions for ZNF257 Gene

Drugs & Compounds for ZNF257 Gene

No Compound Related Data Available

Transcripts for ZNF257 Gene

Unigene Clusters for ZNF257 Gene

Zinc finger protein 257:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF257 Gene

No ASD Table

Relevant External Links for ZNF257 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF257 Gene

mRNA expression in normal human tissues for ZNF257 Gene

SOURCE GeneReport for Unigene cluster for ZNF257 Gene Hs.283900

genes like me logo Genes that share expression patterns with ZNF257: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZNF257 Gene

Orthologs for ZNF257 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF257 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia -- 36
  • 54 (a)
(Canis familiaris)
Mammalia -- 36
  • 40 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 41 (a)
-- 36
  • 52 (a)
(Mus musculus)
Mammalia Zfp429 36
  • 43 (a)
(Pan troglodytes)
Mammalia ZNF257 36
  • 99 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 55 (a)
-- 36
  • 37 (a)
-- 36
  • 43 (a)
-- 36
  • 41 (a)
-- 36
  • 33 (a)
-- 36
  • 33 (a)
-- 36
  • 33 (a)
-- 36
  • 30 (a)
Species with no ortholog for ZNF257:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF257 Gene

Gene Tree for ZNF257 (if available)
Gene Tree for ZNF257 (if available)

Paralogs for ZNF257 Gene

(522) SIMAP similar genes for ZNF257 Gene using alignment to 5 proteins: Pseudogenes for ZNF257 Gene

genes like me logo Genes that share paralogs with ZNF257: view

Variants for ZNF257 Gene

Sequence variations from dbSNP and Humsavar for ZNF257 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs7258080 -- 22,074,823(+) ctata(A/T)aaaag intron-variant
rs7258192 -- 22,081,856(+) tGCTT(A/G)AAGAA intron-variant
rs7258302 -- 22,072,998(+) tattt(A/T)ttttt intron-variant
rs7259776 -- 22,091,008(+) AAACA(C/T)TTTTA utr-variant-3-prime
rs7259971 -- 22,054,517(+) AATGC(C/G)AGTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF257 Gene

Variant ID Type Subtype PubMed ID
esv4924 CNV Complex 18987735
esv2718335 CNV Deletion 23290073
dgv552e201 CNV Deletion 23290073
nsv7306 OTHER Inversion 18451855
dgv3808n71 CNV Gain 21882294
dgv1066e1 CNV Complex 17122850
esv731 CNV CNV 17122850
esv34340 CNV Loss 17911159
nsv833785 CNV Gain 17160897
dgv553e201 CNV Deletion 23290073
dgv633e199 CNV Deletion 23128226
nsv436853 CNV Insertion 17901297
dgv554e201 CNV Deletion 23290073
nsv469674 CNV Complex 16826518
nsv436253 CNV Deletion 17901297
nsv911434 CNV Gain 21882294
nsv436857 CNV Insertion 17901297
nsv911435 CNV Loss 21882294
nsv520741 CNV Loss 19592680
nsv470135 CNV Loss 18288195
nsv525240 CNV Gain 19592680
dgv3812n71 CNV Loss 21882294

Variation tolerance for ZNF257 Gene

Residual Variation Intolerance Score: 91.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.21; 52.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF257 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF257 Gene

Disorders for ZNF257 Gene

Relevant External Links for ZNF257

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF257 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF257 Gene

Publications for ZNF257 Gene

  1. Molecular cloning of six novel Kruppel-like zinc finger genes from hematopoietic cells and identification of a novel transregulatory domain KRNB. (PMID: 10585455) Han Z.-G. … Chen Z. (J. Biol. Chem. 1999) 2 3 4 67
  2. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for ZNF257 Gene

Sources for ZNF257 Gene