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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF257 Gene

protein-coding   GIFtS: 45
GCID: GC19P022235

Zinc Finger Protein 257

  Search for ZNF257
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 2571 2
Bone Marrow Zinc Finger 42 3
BMZF-42 3
BMZF42 3

External Ids:    HGNC: 134981   Entrez Gene: 1138352   Ensembl: ENSG000001971347   OMIM: 6069575   UniProtKB: Q9Y2Q13   

Export aliases for ZNF257 gene to outside databases

Previous GC identifers: GC19P022683 GC19P022564 GC19P022011 GC19P022027 GC19P021773


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF257 Gene: 
ZNF257 (zinc finger protein 257) is a protein-coding gene. Among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF85.

UniProtKB/Swiss-Prot: ZN257_HUMAN, Q9Y2Q1
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011295.11  NC_018930.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ZNF257
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF257 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF257

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF257


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13   Ensembl cytogenetic band:  19p12   HGNC cytogenetic band: 19p13

ZNF257 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF257 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P022235:  view genomic region     (about GC identifiers)

Start:
22,235,254 bp from pter      End:
22,274,282 bp from pter
Size:
39,029 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN257_HUMAN, Q9Y2Q1 (See protein sequence)
Recommended Name: Zinc finger protein 257  
Size: 563 amino acids; 65779 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: B3KPS4 E9PG34 Q8NE34
Alternative splicing: 4 isoforms:  Q9Y2Q1-1   Q9Y2Q1-2   Q9Y2Q1-3   Q9Y2Q1-4   

Explore the universe of human proteins at neXtProt for ZNF257: NX_Q9Y2Q1

Explore proteomics data for ZNF257 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y2Q1

  • ZNF257 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF257 Protein Expression
    REFSEQ proteins: NP_258429.2  
    ENSEMBL proteins: 
     ENSP00000406147   ENSP00000469454   ENSP00000471334   ENSP00000470209   ENSP00000472944  
     ENSP00000469703  
    Reactome Protein details: Q9Y2Q1
    Human Recombinant Protein Products for ZNF257: 
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    Novus Biologicals ZNF257 Lysate
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZNF257 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus NAS--

    ZNF257 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9Y2Q1

    ProtoNet protein and cluster: Q9Y2Q1

    2 Blocks protein domains:
    IPB001909 KRAB box
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZN257_HUMAN, Q9Y2Q1
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 13 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF257 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN257_HUMAN, Q9Y2Q1
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding NAS--
    GO:0008270zinc ion binding NAS10585455
    GO:0046872metal ion binding ----
         
    ZNF257 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF257 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF257
        Generic Transcription Pathway
    Gene Expression



    ZNF257 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF257

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent NAS10585455

    ZNF257 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF257 (ZN257)

    Search CenterWatch for drugs/clinical trials and news about ZNF257 / ZN257

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF257 gene: 
    NM_033468.2  

    Unigene Cluster for ZNF257:

    Zinc finger protein 257
    Hs.283900  [show with all ESTs]
    Unigene Representative Sequence: BC036446
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000435820(uc010ecx.3 uc010ecy.3) ENST00000594363 ENST00000597927
    ENST00000594947 ENST00000597796 ENST00000596471 ENST00000600162
    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate ZNF257:
    hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmidZNF257 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF257

    Additional mRNA sequence: 

    AF070651.1 AK056694.1 BC020045.1 BC036446.1 

    3 DOTS entries:

    DT.91873758  DT.92023614  DT.75156914 

    19 AceView cDNA sequences:

    AA885944 AK056694 BU155753 BC036446 BX100770 NM_033468 AI733046 AI791535 
    AF070651 BP336027 BC020045 AI492755 AA209235 BI553764 AA211940 BG698260 
    AA211939 BG718952 BF086021 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF257 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTATGAGAGA
    ZNF257 Expression
    About this image


    See ZNF257 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF257

    SOURCE GeneReport for Unigene cluster: Hs.283900
        SABiosciences Custom PCR Arrays for ZNF257
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF257

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF257 gene from 1/4 species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    26(a)
    1 → many
    GL343733.1(125230-159240)
            Species with no ortholog for ZNF257

    ENSEMBL Gene Tree for ZNF257 (if available)
    TreeFam Gene Tree for ZNF257 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF257 gene
    ZNF852  ZNF4862  ZNF1952  ZNF7272  ZNF922  ZNF1002  ZNF7322  ZNF6752  
    ZNF1382  ZNF5062  ZNF662  ZNF2732  ZNF6952  ZNF6262  ZNF6802  ZNF4792  
    ZNF2532  ZNF6822  ZNF4922  ZNF6762  ZNF6812  ZNF1412  ZNF7362  ZNF6792  
    ZNF2672  ZNF2542  ZNF7372  ZNF982  ZNF7162  ZNF7142  ZNF5192  ZNF4302  
    ZNF7302  ZNF7082  ZNF1172  ZNF4312  ZNF902  ZNF7262  ZNF7282  
    18/524 SIMAP similar genes for ZNF257 using alignment to 5 protein entries:     ZN257_HUMAN (see all proteins) (see all similar genes):
    MGC12518    HDGFRP2    TNNT1    ZNF273    NDUFS3    ZNF506
    TBCB    ZNF724P    ZNF90    ZNF100    ZNF66    ZNF738
    AARSD1    NXPE2    ZNF429    ZNF98    ZNF675    ZNF730

    ZNF257 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ZNF257
    PGOHUM00000263169


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/938 SNPs in ZNF257 are shown (see all 938)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs745728771,2
    Cuntested122270846(+) AAAGTC/GATACT 2 V syn10--------
    rs1486121151,2
    Cuntested122272101(+) ACAAAC/TGTGAA 2 R C mis10--------
    rs1412667551,2
    --22233375(+) TAGCTC/GAGCAT 1 -- us2k10--------
    rs1912395581,2
    --22233385(+) TGGTGA/GTACAC 1 -- us2k10--------
    rs1830834331,2
    --22233390(+) GTACAC/TGCCTG 1 -- us2k10--------
    rs1856997991,2
    --22233437(+) CACTTA/CAATCC 1 -- us2k10--------
    rs1507805011,2
    --22233452(+) GGCCCA/GATGAT 1 -- us2k10--------
    rs3907301,2
    C,F,H--22233509(-) ATATAT/GAGAGA 1 -- us2k126Minor allele frequency- G:0.24NS EA NA WA CSA 2355
    rs1391361671,2
    --22233658(+) TAATTC/TATTCC 1 -- us2k10--------
    rs4244651,2
    C,F,A--22233678(-) AGAAAA/GAGCAG 1 -- us2k112Minor allele frequency- G:0.47NA WA CSA EA 376

    HapMap Linkage Disequilibrium report for ZNF257 (22235254 - 22274282 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/22 variations for ZNF257 (see all 22):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv554e201CNV Deletion23290073
    dgv552e201CNV Deletion23290073
    esv2718335CNV Deletion23290073
    nsv436253CNV Deletion17901297
    dgv553e201CNV Deletion23290073
    dgv633e199CNV Deletion23128226
    nsv436853CNV Insertion17901297
    nsv436857CNV Insertion17901297
    nsv520741CNV Loss19592680
    esv34340CNV Loss17911159

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZNF257 for disorders           About MalaCards
    OMIM gene information: 606957    OMIM disorders: --


    ZNF257 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZNF257

    Export disorders for ZNF257 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF257 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF257)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of six novel Kruppel-like zinc finger genes from hematopoietic cells and identification of a novel transregulatory domain KRNB. (PubMed id 10585455)1, 2, 3 Han Z.-G.... Chen Z. (1999)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    4. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (2007)
    5. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 113835 HGNC: 13498 AceView: ZNF257 Ensembl:ENSG00000197134 euGenes: HUgn113835
    ECgene: ZNF257 H-InvDB: ZNF257

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF257 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF257 gene:
    Search GeneIP for patents involving ZNF257

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     Proteins for ZNF257
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
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