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Aliases for ZNF257 Gene

Aliases for ZNF257 Gene

  • Zinc Finger Protein 257 2 3
  • Bone Marrow Zinc Finger 4 3 4
  • BMZF-4 3 4
  • BMZF4 3 4

External Ids for ZNF257 Gene

Previous GeneCards Identifiers for ZNF257 Gene

  • GC19P022683
  • GC19P022564
  • GC19P022011
  • GC19P022235
  • GC19P021773

Summaries for ZNF257 Gene

GeneCards Summary for ZNF257 Gene

ZNF257 (Zinc Finger Protein 257) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF253.

UniProtKB/Swiss-Prot for ZNF257 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF257 Gene

Genomics for ZNF257 Gene

Genomic Location for ZNF257 Gene

Start:
22,052,448 bp from pter
End:
22,091,480 bp from pter
Size:
39,033 bases
Orientation:
Plus strand

Genomic View for ZNF257 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF257 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF257 Gene

No data available for Regulatory Elements for ZNF257 Gene

Proteins for ZNF257 Gene

  • Protein details for ZNF257 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2Q1-ZN257_HUMAN
    Recommended name:
    Zinc finger protein 257
    Protein Accession:
    Q9Y2Q1
    Secondary Accessions:
    • B3KPS4
    • E9PG34
    • Q8NE34

    Protein attributes for ZNF257 Gene

    Size:
    563 amino acids
    Molecular mass:
    65779 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF257 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF257 Gene

Proteomics data for ZNF257 Gene at MOPED

Post-translational modifications for ZNF257 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF257 Gene

No data available for DME Specific Peptides for ZNF257 Gene

Domains for ZNF257 Gene

Gene Families for ZNF257 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Suggested Antigen Peptide Sequences for ZNF257 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y2Q1

UniProtKB/Swiss-Prot:

ZN257_HUMAN :
  • Q9Y2Q1
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 13 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF257: view

Function for ZNF257 Gene

Molecular function for ZNF257 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF257 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0008270 zinc ion binding NAS 10585455
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with ZNF257: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF257 Gene

Localization for ZNF257 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF257 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF257 Gene COMPARTMENTS Subcellular localization image for ZNF257 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF257 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF257: view

Pathways for ZNF257 Gene

SuperPathways for ZNF257 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF257: view

Pathways by source for ZNF257 Gene

2 Reactome pathways for ZNF257 Gene

Interacting Proteins for ZNF257 Gene

Gene Ontology (GO) - Biological Process for ZNF257 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 10585455
genes like me logo Genes that share ontologies with ZNF257: view

Transcripts for ZNF257 Gene

Unigene Clusters for ZNF257 Gene

Zinc finger protein 257:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF257

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ZNF257
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF257 Gene

No ASD Table

Relevant External Links for ZNF257 Gene

GeneLoc Exon Structure for
ZNF257
ECgene alternative splicing isoforms for
ZNF257

Expression for ZNF257 Gene

mRNA expression in normal human tissues for ZNF257 Gene

SOURCE GeneReport for Unigene cluster for ZNF257 Gene Hs.283900

genes like me logo Genes that share expressions with ZNF257: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for ZNF257 Gene

Orthologs for ZNF257 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF257 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF257 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 54 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 40 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Zfp429 36
  • 43 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 41 (a)
ManyToMany
-- 36
  • 52 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 55 (a)
ManyToMany
-- 36
  • 37 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
Species with no ortholog for ZNF257:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF257 Gene

ENSEMBL:
Gene Tree for ZNF257 (if available)
TreeFam:
Gene Tree for ZNF257 (if available)

Paralogs for ZNF257 Gene

Selected SIMAP similar genes for ZNF257 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for ZNF257 Gene

genes like me logo Genes that share paralogs with ZNF257: view

Variants for ZNF257 Gene

Sequence variations from dbSNP and Humsavar for ZNF257 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs366849 -- 22,052,139(-) ggaga(A/C)tcgct upstream-variant-2KB
rs366863 -- 22,052,126(-) aaccc(A/G)ggagg upstream-variant-2KB
rs367280 -- 22,051,986(-) ATAAC(A/C)ACTAT upstream-variant-2KB
rs387156 -- 22,051,648(-) gggca(A/C)caaaa upstream-variant-2KB
rs387315 -- 22,052,724(-) actgc(A/G)aggag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF257 Gene

Variant ID Type Subtype PubMed ID
esv4924 CNV Complex 18987735
esv2718335 CNV Deletion 23290073
dgv552e201 CNV Deletion 23290073
nsv7306 OTHER Inversion 18451855
dgv3808n71 CNV Gain 21882294
dgv1066e1 CNV Complex 17122850
esv731 CNV CNV 17122850
esv34340 CNV Loss 17911159
nsv833785 CNV Gain 17160897
dgv553e201 CNV Deletion 23290073
dgv633e199 CNV Deletion 23128226
nsv436853 CNV Insertion 17901297
dgv554e201 CNV Deletion 23290073
nsv469674 CNV Complex 16826518
nsv436253 CNV Deletion 17901297
nsv911434 CNV Gain 21882294
nsv436857 CNV Insertion 17901297
nsv911435 CNV Loss 21882294
nsv520741 CNV Loss 19592680
nsv470135 CNV Loss 18288195
nsv525240 CNV Gain 19592680
dgv3812n71 CNV Loss 21882294

Relevant External Links for ZNF257 Gene

HapMap Linkage Disequilibrium report
ZNF257

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF257 Gene

Disorders for ZNF257 Gene

Relevant External Links for ZNF257

Genetic Association Database (GAD)
ZNF257
genes like me logo Genes that share disorders with ZNF257: view

No data available for UniProtKB/Swiss-Prot for ZNF257 Gene

Publications for ZNF257 Gene

  1. Molecular cloning of six novel Kruppel-like zinc finger genes from hematopoietic cells and identification of a novel transregulatory domain KRNB. (PMID: 10585455) Han Z.-G. … Chen Z. (J. Biol. Chem. 1999) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PMID: 22505724) Udeshi N.D. … Carr S.A. (Mol. Cell Proteomics 2012) 3
  4. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PMID: 17903299) Kathiresan S. … Cupples L.A. (BMC Med. Genet. 2007) 48
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4

Products for ZNF257 Gene

Sources for ZNF257 Gene

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