ZNF256 Gene
protein-coding GIFtS: 45
GCID: GC19M058452
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zinc finger protein 256
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Aliases
for ZNF256 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 2561 2 | | BMZF-31 2 3 | | Bone Marrow Zinc Finger 32 3 | | BMZF32 3 |
Export aliases for ZNF256 gene to outside databasesPrevious GC identifers: GC19M059282 GC19M058905 GC19M063123 GC19M063143 GC19M063144 GC19M054763 |
Summaries
for ZNF256 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN256_HUMAN, Q9Y2P7Function: Transcriptional repressor that plays a role in cell proliferation. Requires TRIM28 for its activity
|
Genomic Views
for ZNF256 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF256 gene promoter:
GATA-3 AP-1 ATF-2 c-Jun LCR-F1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF256
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF256 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.43 Ensembl cytogenetic band: 19q13.43 HGNC cytogenetic band: 19q13ZNF256 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M058452: view genomic region
(about GC identifiers)
Start:
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58,452,201 bp from pter |
End:
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58,459,077 bp from pter |
Size:
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6,877 bases |
Orientation:
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minus strand |
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Proteins
for ZNF256 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN256_HUMAN, Q9Y2P7 (See
protein sequence)Recommended Name: Zinc finger protein 256 Size: 627 amino acids; 71871 Da
Subunit: Interacts with TRIM28
Subcellular location: Nucleus
Secondary accessions: B2RA92 Q53Y85 Q9BV71Alternative splicing: 2 isoforms: Q9Y2P7-1 Q9Y2P7-2 Explore the universe of human proteins at neXtProt for ZNF256: NX_Q9Y2P7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y2P7
ZNF256 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_005764.2
ENSEMBL proteins: ENSP00000282308 Reactome Protein details: Q9Y2P7
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
ZNF256 for ontologies About GeneDecksing
ZNF256 Antibody Products:
Assay Products for ZNF256: |
Protein
Domains /
Families
for ZNF256 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF256 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9Y2P7ProtoNet protein and cluster: Q9Y2P7 1 Blocks protein family: IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: ZN256_HUMAN, Q9Y2P7Domain: The KRAB domain mediates interaction with TRIM28 and is required for transcriptional repressor activitySimilarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 15 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF256 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZN256_HUMAN, Q9Y2P7Function: Transcriptional repressor that plays a role in cell proliferation. Requires TRIM28 for its activityInduction: By GDNF/glial cell line-derived neurotrophic factor
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF256
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF256
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZNF256 (NM_005773) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF256 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF256 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF256 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
ZNF256 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZNF256 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF256
ZNF256 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZNF256
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
ZNF256 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF256 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF256
Search CenterWatch for drugs/clinical trials and news about ZNF256 / ZN256
|
Transcripts
for ZNF256 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF256 gene: NM_005773.2 Unigene Cluster for ZNF256: Zinc finger protein 256 Hs.596242 [show with all ESTs]Unigene Representative Sequence: NM_0057731 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000282308(uc002qqu.3 uc010euj.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF256
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF256
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF256 (NM_005773) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF256 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF256 |
Additional cDNA sequence: AF067165.1 AK314094.1 BC001438.1 BT006853.1 4 DOTS entries: DT.95152550 DT.95227492 DT.70103719 DT.75177852 24/28 AceView cDNA sequences (see all 28): BF510334 BF508722 BM452054 NM_005773 AI087275 BC001438 BT006853 BP335651 BE265862 AA306773 AW151772 BM463060 AU280306 CA406341 BX475520 BG287031 AW054759 BV191696 AA507587 BG481284 BG336545 CD656453 AF067165 BE281602
GeneLoc Exon Structure
|
Expression
for ZNF256 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF256 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGAGAGTTCA
About this image
See ZNF256 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF256
SOURCE GeneReport for Unigene cluster: Hs.596242
SABiosciences Custom PCR Arrays for ZNF256
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF256
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZNF256 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF256 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF256 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF256 |
Orthologs
for ZNF256 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for ZNF256 (if available)
TreeFam Gene Tree for ZNF256 (if available) |
Paralogs
for ZNF256 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF256 gene
- ZNF5492 ZNF2112 ZNF4172 ZNF7922 ZNF7492 ZNF5512 ZNF7762 ZNF5472
- ZNF172 ZNF4162 ZNF5482 ZNF3042 ZNF587B2 ZNF7732 ZNF1322 ZIK12
- ZNF6712 ZNF1342 ZNF4182 ZNF1542 ZNF5522 ZNF7722 ZNF5302 ZNF4192
18/436 SIMAP similar genes for ZNF256 using alignment to 3 protein entries: ZN256_HUMAN (see all proteins)
(see all similar genes):DKFZp666C237 HZF36 ZNF232 ZNF436 DKFZp666M039 ZNF383
HZF30 ZNF852 ZKSCAN1 ZNF146 ZNF485 ZNF883
ZSCAN16 ZSCAN21 DKFZp686N14223 ZFP92 ZFS-1 ZNF3
ZNF256 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ZNF256
PGOHUM00000241151
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Genomic Variants
for ZNF256 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF256 (58452201 - 58459077 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF256: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF256 |
|
Disorders
/ Diseases
for ZNF256 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 ZNF256 for disorders About MalaCards
ZNF256 for disorders About GeneDecksing
OMIM gene information: 606956
OMIM disorders: --
Export disorders for ZNF256 gene to outside databases
|
Publications
for ZNF256 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF256 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF256) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A novel GDNF-inducible gene, BMZF3, encodes a transcriptional repressor associated with KAP-1. (PubMed id 18060868)1, 2 Suzuki C.... Takahashi M. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Molecular cloning of six novel Kruppel-like zinc finger genes from hematopoietic cells and identification of a novel transregulatory domain KRNB. (PubMed id 10585455)1, 2 Han Z.-G.... Chen Z. (1999)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis. (PubMed id 12878157)1 Imabayashi H.... Umezawa A. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for ZNF256 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF256 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF256 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF256 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF256 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF256 gene:
Search GeneIP for patents involving ZNF256
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF256 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF256 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF256 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF256 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF256 | | OriGene 3'-UTR Clone for ZNF256 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF256 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF256 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | Search Tocris compounds for ZNF256 |
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 | | | ZNF256 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF256 |
|  |  |  | | | | ThermoFisher Antibodies for ZNF256 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF256 |
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