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Aliases for ZNF256 Gene

Aliases for ZNF256 Gene

  • Zinc Finger Protein 256 2 3 5
  • Bone Marrow Zinc Finger 3 3 4
  • BMZF-3 3 4
  • BMZF3 3 4

External Ids for ZNF256 Gene

Previous GeneCards Identifiers for ZNF256 Gene

  • GC19M059282
  • GC19M058905
  • GC19M063123
  • GC19M063143
  • GC19M063144
  • GC19M058452
  • GC19M054763

Summaries for ZNF256 Gene

GeneCards Summary for ZNF256 Gene

ZNF256 (Zinc Finger Protein 256) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF211.

UniProtKB/Swiss-Prot for ZNF256 Gene

  • Transcriptional repressor that plays a role in cell proliferation. Requires TRIM28 for its activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF256 Gene

Genomics for ZNF256 Gene

Regulatory Elements for ZNF256 Gene

Enhancers for ZNF256 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F057809 1.2 FANTOM5 ENCODE 49.5 +134.5 134530 7.2 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 ZNF134 ZNF805 ZNF264 TRIM28 ZNF256 ZNF543 ZNF417 ZNF773 ZNF17 ENSG00000269867
GH19F058181 0.5 ENCODE 41.6 -235.5 -235490 2.5 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF416 ZNF134 ZNF773 ZNF550 ZNF256 ZNF543 ZNF551 ZNF549 ZNF17 ZNF417 ZNF776
GH19F058325 0.2 ENCODE 34.9 -379.1 -379124 3.6 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF134 ZNF17 ZNF549 ZNF606 ZNF773 ZNF256 ZNF417 ZNF551 ZNF548 ZNF211
GH19F057613 0.6 ENCODE 16.5 +333.4 333371 1.5 ATF1 PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A ETS1 YY1 GLIS2 ELK1 ZNF805 ZNF134 ZNF256 ZNF550 ZNF773 ZNF264 ENSG00000268392 ZNF417 ZNF543 TRIM28
GH19F057171 0.5 Ensembl ENCODE 16.5 +775.3 775347 2.0 ZNF48 ZNF2 ZNF366 ZNF548 SP3 CEBPB ZFP69B ZNF585B ZNF341 GLIS1 LOC100132009 ZNF17 ZNF134 ZNF773 ZNF417 ZNF805 ZNF606 ZNF549 AURKC ZNF256
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZNF256 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF256 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000349247 446 2599 HDGF PKNOX1 ATF1 MLX ARID4B DMAP1 ZNF48 ZNF2 ETS1 YY1

Genomic Location for ZNF256 Gene

Chromosome:
19
Start:
57,940,833 bp from pter
End:
57,947,747 bp from pter
Size:
6,915 bases
Orientation:
Minus strand

Genomic View for ZNF256 Gene

Genes around ZNF256 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF256 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF256 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF256 Gene

Proteins for ZNF256 Gene

  • Protein details for ZNF256 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2P7-ZN256_HUMAN
    Recommended name:
    Zinc finger protein 256
    Protein Accession:
    Q9Y2P7
    Secondary Accessions:
    • B2RA92
    • Q53Y85
    • Q9BV71

    Protein attributes for ZNF256 Gene

    Size:
    627 amino acids
    Molecular mass:
    71871 Da
    Quaternary structure:
    • Interacts with TRIM28.

    Alternative splice isoforms for ZNF256 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF256 Gene

Post-translational modifications for ZNF256 Gene

  • Ubiquitination at Lys 447
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF256 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF256 Gene

Domains & Families for ZNF256 Gene

Gene Families for ZNF256 Gene

Protein Domains for ZNF256 Gene

Suggested Antigen Peptide Sequences for ZNF256 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y2P7

UniProtKB/Swiss-Prot:

ZN256_HUMAN :
  • The KRAB domain mediates interaction with TRIM28 and is required for transcriptional repressor activity.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 15 C2H2-type zinc fingers.
Domain:
  • The KRAB domain mediates interaction with TRIM28 and is required for transcriptional repressor activity.
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 15 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF256: view

Function for ZNF256 Gene

Molecular function for ZNF256 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor that plays a role in cell proliferation. Requires TRIM28 for its activity.
UniProtKB/Swiss-Prot Induction:
By GDNF/glial cell line-derived neurotrophic factor.

Gene Ontology (GO) - Molecular Function for ZNF256 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding TAS 10585455
GO:0005515 protein binding IPI 18060868
genes like me logo Genes that share ontologies with ZNF256: view
genes like me logo Genes that share phenotypes with ZNF256: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF256 Gene

Localization for ZNF256 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF256 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF256 Gene COMPARTMENTS Subcellular localization image for ZNF256 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF256 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA,IDA 18060868
genes like me logo Genes that share ontologies with ZNF256: view

Pathways & Interactions for ZNF256 Gene

SuperPathways for ZNF256 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF256: view

Pathways by source for ZNF256 Gene

2 Reactome pathways for ZNF256 Gene

Interacting Proteins for ZNF256 Gene

Gene Ontology (GO) - Biological Process for ZNF256 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organism development TAS 10585455
GO:0045892 negative regulation of transcription, DNA-templated IDA 18060868
genes like me logo Genes that share ontologies with ZNF256: view

No data available for SIGNOR curated interactions for ZNF256 Gene

Transcripts for ZNF256 Gene

mRNA/cDNA for ZNF256 Gene

Unigene Clusters for ZNF256 Gene

Zinc finger protein 256:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF256 Gene

No ASD Table

Relevant External Links for ZNF256 Gene

GeneLoc Exon Structure for
ZNF256
ECgene alternative splicing isoforms for
ZNF256

Expression for ZNF256 Gene

mRNA expression in normal human tissues for ZNF256 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF256 Gene:

ZNF256

SOURCE GeneReport for Unigene cluster for ZNF256 Gene:

Hs.596242
genes like me logo Genes that share expression patterns with ZNF256: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ZNF256 Gene

Orthologs for ZNF256 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF256 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF256 34 35
  • 99.42 (n)
dog
(Canis familiaris)
Mammalia LOC491462 34
  • 69.21 (n)
cow
(Bos Taurus)
Mammalia LOC509810 34
  • 67.85 (n)
Species where no ortholog for ZNF256 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF256 Gene

ENSEMBL:
Gene Tree for ZNF256 (if available)
TreeFam:
Gene Tree for ZNF256 (if available)

Paralogs for ZNF256 Gene

(438) SIMAP similar genes for ZNF256 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for ZNF256 Gene

genes like me logo Genes that share paralogs with ZNF256: view

Variants for ZNF256 Gene

Sequence variations from dbSNP and Humsavar for ZNF256 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10406142 -- 57,940,601(+) tttga(A/G)gtgat downstream-variant-500B
rs10406781 -- 57,948,302(+) cccag(C/T)tactc upstream-variant-2KB
rs10406783 -- 57,948,305(+) agcta(C/T)tccgg upstream-variant-2KB
rs10414058 -- 57,941,956(+) CGGTG(A/C/T)GTAAT reference, synonymous-codon
rs10418365 -- 57,946,387(+) TTACT(C/T)CTATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF256 Gene

Variant ID Type Subtype PubMed ID
esv3644913 CNV gain 21293372
esv3893258 CNV gain 25118596
nsv1066059 CNV gain 25217958

Variation tolerance for ZNF256 Gene

Residual Variation Intolerance Score: 46.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.79; 33.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF256 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF256

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF256 Gene

Disorders for ZNF256 Gene

Relevant External Links for ZNF256

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF256

No disorders were found for ZNF256 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF256 Gene

Publications for ZNF256 Gene

  1. A novel GDNF-inducible gene, BMZF3, encodes a transcriptional repressor associated with KAP-1. (PMID: 18060868) Suzuki C. … Takahashi M. (Biochem. Biophys. Res. Commun. 2008) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Molecular cloning of six novel Kruppel-like zinc finger genes from hematopoietic cells and identification of a novel transregulatory domain KRNB. (PMID: 10585455) Han Z.-G. … Chen Z. (J. Biol. Chem. 1999) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4 64

Products for ZNF256 Gene

Sources for ZNF256 Gene

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