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Aliases for ZNF256 Gene

Aliases for ZNF256 Gene

  • Zinc Finger Protein 256 2 3
  • Bone Marrow Zinc Finger 3 3 4
  • BMZF-3 3 4
  • BMZF3 3 4

External Ids for ZNF256 Gene

Previous GeneCards Identifiers for ZNF256 Gene

  • GC19M059282
  • GC19M058905
  • GC19M063123
  • GC19M063143
  • GC19M063144
  • GC19M058452
  • GC19M054763

Summaries for ZNF256 Gene

GeneCards Summary for ZNF256 Gene

ZNF256 (Zinc Finger Protein 256) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZNF17.

UniProtKB/Swiss-Prot for ZNF256 Gene

  • Transcriptional repressor that plays a role in cell proliferation. Requires TRIM28 for its activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF256 Gene

Genomics for ZNF256 Gene

Regulatory Elements for ZNF256 Gene

Genomic Location for ZNF256 Gene

Start:
57,940,833 bp from pter
End:
57,947,709 bp from pter
Size:
6,877 bases
Orientation:
Minus strand

Genomic View for ZNF256 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF256 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF256 Gene

Proteins for ZNF256 Gene

  • Protein details for ZNF256 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2P7-ZN256_HUMAN
    Recommended name:
    Zinc finger protein 256
    Protein Accession:
    Q9Y2P7
    Secondary Accessions:
    • B2RA92
    • Q53Y85
    • Q9BV71

    Protein attributes for ZNF256 Gene

    Size:
    627 amino acids
    Molecular mass:
    71871 Da
    Quaternary structure:
    • Interacts with TRIM28.

    Alternative splice isoforms for ZNF256 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF256 Gene

Proteomics data for ZNF256 Gene at MOPED

Post-translational modifications for ZNF256 Gene

  • Ubiquitination at Lys447
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF256 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF256 Gene

Domains for ZNF256 Gene

Gene Families for ZNF256 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Suggested Antigen Peptide Sequences for ZNF256 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y2P7

UniProtKB/Swiss-Prot:

ZN256_HUMAN :
  • Q9Y2P7
Domain:
  • The KRAB domain mediates interaction with TRIM28 and is required for transcriptional repressor activity.
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 15 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF256: view

Function for ZNF256 Gene

Molecular function for ZNF256 Gene

UniProtKB/Swiss-Prot Function: Transcriptional repressor that plays a role in cell proliferation. Requires TRIM28 for its activity.
UniProtKB/Swiss-Prot Induction: By GDNF/glial cell line-derived neurotrophic factor.

Gene Ontology (GO) - Molecular Function for ZNF256 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 10585455
GO:0005515 protein binding IPI 18060868
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF256: view

miRNA for ZNF256 Gene

miRTarBase miRNAs that target ZNF256

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF256 Gene

Localization for ZNF256 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF256 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF256 Gene COMPARTMENTS Subcellular localization image for ZNF256 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF256 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with ZNF256: view

Pathways for ZNF256 Gene

SuperPathways for ZNF256 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF256: view

Pathways by source for ZNF256 Gene

2 Reactome pathways for ZNF256 Gene

Interacting Proteins for ZNF256 Gene

Gene Ontology (GO) - Biological Process for ZNF256 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0007275 multicellular organismal development TAS 10585455
GO:0045892 negative regulation of transcription, DNA-templated IDA 18060868
genes like me logo Genes that share ontologies with ZNF256: view

Transcripts for ZNF256 Gene

mRNA/cDNA for ZNF256 Gene

Unigene Clusters for ZNF256 Gene

Zinc finger protein 256:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF256 Gene

No ASD Table

Relevant External Links for ZNF256 Gene

GeneLoc Exon Structure for
ZNF256
ECgene alternative splicing isoforms for
ZNF256

Expression for ZNF256 Gene

mRNA expression in normal human tissues for ZNF256 Gene

SOURCE GeneReport for Unigene cluster for ZNF256 Gene Hs.596242

genes like me logo Genes that share expressions with ZNF256: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for ZNF256 Gene

Orthologs for ZNF256 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF256 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF256 35
  • 99.42 (n)
  • 99.36 (a)
ZNF256 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC509810 35
  • 67.85 (n)
  • 52.96 (a)
dog
(Canis familiaris)
Mammalia LOC491462 35
  • 69.21 (n)
  • 55.12 (a)
Species with no ortholog for ZNF256:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF256 Gene

ENSEMBL:
Gene Tree for ZNF256 (if available)
TreeFam:
Gene Tree for ZNF256 (if available)

Paralogs for ZNF256 Gene

Selected SIMAP similar genes for ZNF256 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for ZNF256 Gene

genes like me logo Genes that share paralogs with ZNF256: view

Variants for ZNF256 Gene

Sequence variations from dbSNP and Humsavar for ZNF256 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs257652 -- 57,944,013(-) AAGGA(A/C/G/T)TGGGG reference, missense, intron-variant
rs257653 -- 57,945,490(+) gagct(G/T)attca intron-variant
rs257654 -- 57,946,563(+) AAATC(A/G)CGATC intron-variant
rs257655 -- 57,947,116(+) AAACG(C/T)AGAAA intron-variant
rs257656 -- 57,948,840(+) CCCAA(A/T)TGTAG upstream-variant-2KB

Relevant External Links for ZNF256 Gene

HapMap Linkage Disequilibrium report
ZNF256

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZNF256 Gene

Disorders for ZNF256 Gene

No disorders were found for ZNF256 Gene.

No data available for UniProtKB/Swiss-Prot for ZNF256 Gene

Publications for ZNF256 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. A novel GDNF-inducible gene, BMZF3, encodes a transcriptional repressor associated with KAP-1. (PMID: 18060868) Suzuki C. … Takahashi M. (Biochem. Biophys. Res. Commun. 2008) 3 4
  3. Molecular cloning of six novel Kruppel-like zinc finger genes from hematopoietic cells and identification of a novel transregulatory domain KRNB. (PMID: 10585455) Han Z.-G. … Chen Z. (J. Biol. Chem. 1999) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis. (PMID: 12878157) Imabayashi H. … Umezawa A. (Exp. Cell Res. 2003) 3

Products for ZNF256 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ZNF256
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF256
    • Block miRNA regulation of ZNF256 using miScript Target Protectors

    Sources for ZNF256 Gene

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