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Aliases for ZNF256 Gene

Aliases for ZNF256 Gene

  • Zinc Finger Protein 256 2 3 5
  • Bone Marrow Zinc Finger 3 3 4
  • BMZF-3 3 4
  • BMZF3 3 4

External Ids for ZNF256 Gene

Previous GeneCards Identifiers for ZNF256 Gene

  • GC19M059282
  • GC19M058905
  • GC19M063123
  • GC19M063143
  • GC19M063144
  • GC19M058452
  • GC19M054763

Summaries for ZNF256 Gene

GeneCards Summary for ZNF256 Gene

ZNF256 (Zinc Finger Protein 256) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ZNF418.

UniProtKB/Swiss-Prot for ZNF256 Gene

  • Transcriptional repressor that plays a role in cell proliferation. Requires TRIM28 for its activity.

Additional gene information for ZNF256 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF256 Gene

Genomics for ZNF256 Gene

GeneHancer (GH) Regulatory Elements for ZNF256 Gene

Promoters and enhancers for ZNF256 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I057946 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.2 207 1.8 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 ETS1 ZNF256 LOC100128398 ZNF417 ERVK3-1 MZF1 ZNF549 ZNF329 PIR55331
GH19I058181 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 52.7 -235.5 -235489 2.5 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF274 ZNF134 ZNF606 ZNF17 ZNF417 ZNF549 ZNF550 ZNF773 LOC105372483 ZNF264
GH19I058325 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 44.8 -379.1 -379124 3.6 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZSCAN22 LOC105372480 PIR44424 ZNF134 ZNF606 ZNF417 ZNF549 ZNF135 ZNF17 ZNF446
GH19I058517 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 22.5 -572.0 -571961 4.9 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 ZBTB45 PIR40518 ZNF324B TRIM28 ZNF446 ZNF134 ZNF417 ZSCAN22 ZNF549 ZNF274
GH19I057278 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 19.8 +666.3 666271 6.7 ZFP64 FEZF1 DMAP1 YY1 E2F8 ZNF143 SP3 NFYC ZC3H11A MEF2D ZNF460 ZNF460-AS1 ZNF264 ZNF805 ZNF134 ZNF543 ZNF549 ZNF17 ZNF329 ZNF256
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF256 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF256 gene promoter:

Genomic Locations for ZNF256 Gene

Genomic Locations for ZNF256 Gene
chr19:57,940,833-57,947,747
(GRCh38/hg38)
Size:
6,915 bases
Orientation:
Minus strand
chr19:58,452,201-58,459,077
(GRCh37/hg19)

Genomic View for ZNF256 Gene

Genes around ZNF256 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF256 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF256 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF256 Gene

Proteins for ZNF256 Gene

  • Protein details for ZNF256 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2P7-ZN256_HUMAN
    Recommended name:
    Zinc finger protein 256
    Protein Accession:
    Q9Y2P7
    Secondary Accessions:
    • B2RA92
    • Q53Y85
    • Q9BV71

    Protein attributes for ZNF256 Gene

    Size:
    627 amino acids
    Molecular mass:
    71871 Da
    Quaternary structure:
    • Interacts with TRIM28.

    Alternative splice isoforms for ZNF256 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF256 Gene

Post-translational modifications for ZNF256 Gene

Other Protein References for ZNF256 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF256 Gene

Domains & Families for ZNF256 Gene

Gene Families for ZNF256 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF256 Gene

Suggested Antigen Peptide Sequences for ZNF256 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y2P7

UniProtKB/Swiss-Prot:

ZN256_HUMAN :
  • The KRAB domain mediates interaction with TRIM28 and is required for transcriptional repressor activity.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Domain:
  • The KRAB domain mediates interaction with TRIM28 and is required for transcriptional repressor activity.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF256: view

Function for ZNF256 Gene

Molecular function for ZNF256 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor that plays a role in cell proliferation. Requires TRIM28 for its activity.
UniProtKB/Swiss-Prot Induction:
By GDNF/glial cell line-derived neurotrophic factor.

Gene Ontology (GO) - Molecular Function for ZNF256 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity TAS 10585455
GO:0005515 protein binding IPI 18060868
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF256: view
genes like me logo Genes that share phenotypes with ZNF256: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF256 Gene

Localization for ZNF256 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF256 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF256 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF256 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IDA,IEA 18060868
genes like me logo Genes that share ontologies with ZNF256: view

Pathways & Interactions for ZNF256 Gene

SuperPathways for ZNF256 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF256: view

Pathways by source for ZNF256 Gene

2 Reactome pathways for ZNF256 Gene

Gene Ontology (GO) - Biological Process for ZNF256 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organism development TAS 10585455
GO:0045892 negative regulation of transcription, DNA-templated IDA 18060868
genes like me logo Genes that share ontologies with ZNF256: view

No data available for SIGNOR curated interactions for ZNF256 Gene

Drugs & Compounds for ZNF256 Gene

No Compound Related Data Available

Transcripts for ZNF256 Gene

mRNA/cDNA for ZNF256 Gene

Unigene Clusters for ZNF256 Gene

Zinc finger protein 256:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF256 Gene

No ASD Table

Relevant External Links for ZNF256 Gene

GeneLoc Exon Structure for
ZNF256
ECgene alternative splicing isoforms for
ZNF256

Expression for ZNF256 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF256 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF256 Gene:

ZNF256

SOURCE GeneReport for Unigene cluster for ZNF256 Gene:

Hs.596242

Evidence on tissue expression from TISSUES for ZNF256 Gene

  • Bone marrow(4.1)
  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with ZNF256: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF256 Gene

Orthologs for ZNF256 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF256 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF256 33 34
  • 99.42 (n)
dog
(Canis familiaris)
Mammalia LOC491462 33
  • 69.21 (n)
cow
(Bos Taurus)
Mammalia LOC509810 33
  • 67.85 (n)
Species where no ortholog for ZNF256 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF256 Gene

ENSEMBL:
Gene Tree for ZNF256 (if available)
TreeFam:
Gene Tree for ZNF256 (if available)

Paralogs for ZNF256 Gene

(438) SIMAP similar genes for ZNF256 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for ZNF256 Gene

genes like me logo Genes that share paralogs with ZNF256: view

Variants for ZNF256 Gene

Sequence variations from dbSNP and Humsavar for ZNF256 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000137206 -- 57,945,863(-) C/A intron_variant
rs1000330065 -- 57,949,339(-) C/T upstream_transcript_variant
rs1000412719 -- 57,943,325(-) G/A intron_variant
rs1000694413 -- 57,943,845(-) T/C intron_variant
rs1000725051 -- 57,943,579(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF256 Gene

Variant ID Type Subtype PubMed ID
esv3644913 CNV gain 21293372
esv3893258 CNV gain 25118596
nsv1066059 CNV gain 25217958

Variation tolerance for ZNF256 Gene

Residual Variation Intolerance Score: 46.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.79; 33.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF256 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF256

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF256 Gene

Disorders for ZNF256 Gene

Additional Disease Information for ZNF256

No disorders were found for ZNF256 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF256 Gene

Publications for ZNF256 Gene

  1. A novel GDNF-inducible gene, BMZF3, encodes a transcriptional repressor associated with KAP-1. (PMID: 18060868) Suzuki C … Takahashi M (Biochemical and biophysical research communications 2008) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Molecular cloning of six novel Krüppel-like zinc finger genes from hematopoietic cells and identification of a novel transregulatory domain KRNB. (PMID: 10585455) Han ZG … Chen Z (The Journal of biological chemistry 1999) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 58

Products for ZNF256 Gene

Sources for ZNF256 Gene

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