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Aliases for ZNF254 Gene

Aliases for ZNF254 Gene

  • Zinc Finger Protein 254 2 3
  • Zinc Finger Protein 539 2 3 4
  • ZNF91L 3 4 6
  • Hematopoietic Cell-Derived Zinc Finger Protein 1 3 4
  • Bone Marrow Zinc Finger 5 3 4
  • HD-ZNF1 3 4
  • ZNF539 3 4
  • BMZF-5 3 4
  • Zinc Finger Protein 91-Like 4
  • BMZF5 4

External Ids for ZNF254 Gene

Previous HGNC Symbols for ZNF254 Gene

  • ZNF91L
  • ZNF539

Previous GeneCards Identifiers for ZNF254 Gene

  • GC19U990156
  • GC19P024605
  • GC19P023992
  • GC19P024061
  • GC19P024048
  • GC19P024269
  • GC19P023824
  • GC19P024217

Summaries for ZNF254 Gene

Entrez Gene Summary for ZNF254 Gene

  • Zinc finger proteins have been shown to interact with nucleic acids and to have diverse functions. The zinc finger domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines that are involved in coordinating zinc. Kruppel-related proteins form 1 family of zinc finger proteins. See ZFP93 (MIM 604749) for additional information on zinc finger proteins.[supplied by OMIM, Jul 2002]

GeneCards Summary for ZNF254 Gene

ZNF254 (Zinc Finger Protein 254) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF253.

UniProtKB/Swiss-Prot for ZNF254 Gene

  • May be involved in transcriptional regulation

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF254 Gene

Genomics for ZNF254 Gene

Genomic Location for ZNF254 Gene

23,833,255 bp from pter
24,129,968 bp from pter
296,714 bases
Plus strand

Genomic View for ZNF254 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF254 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF254 Gene

No data available for Regulatory Elements for ZNF254 Gene

Proteins for ZNF254 Gene

  • Protein details for ZNF254 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 254
    Protein Accession:
    Secondary Accessions:
    • A4QPC0
    • Q86XL7

    Protein attributes for ZNF254 Gene

    659 amino acids
    Molecular mass:
    77160 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF254 Gene


neXtProt entry for ZNF254 Gene

Proteomics data for ZNF254 Gene at MOPED

Post-translational modifications for ZNF254 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF254 Gene

Domains for ZNF254 Gene

Gene Families for ZNF254 Gene

Suggested Antigen Peptide Sequences for ZNF254 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 15 C2H2-type zinc fingers.
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 15 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF254: view

Function for ZNF254 Gene

Molecular function for ZNF254 Gene

GENATLAS Biochemistry:
zinc finger protein254
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF254 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF254: view

Phenotypes for ZNF254 Gene

GenomeRNAi human phenotypes for ZNF254:
genes like me logo Genes that share phenotypes with ZNF254: view

Animal Model Products

CRISPR Products

miRNA for ZNF254 Gene

miRTarBase miRNAs that target ZNF254

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF254 Gene

Localization for ZNF254 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF254 Gene

Subcellular locations from

Jensen Localization Image for ZNF254 Gene COMPARTMENTS Subcellular localization image for ZNF254 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF254 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF254: view

Pathways for ZNF254 Gene

SuperPathways for ZNF254 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF254: view

Pathways by source for ZNF254 Gene

2 Reactome pathways for ZNF254 Gene

Interacting Proteins for ZNF254 Gene

Gene Ontology (GO) - Biological Process for ZNF254 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS 10585455
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
genes like me logo Genes that share ontologies with ZNF254: view

Transcripts for ZNF254 Gene

Unigene Clusters for ZNF254 Gene

Zinc finger protein 254:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF254

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF254 Gene

No ASD Table

Relevant External Links for ZNF254 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF254 Gene

mRNA expression in normal human tissues for ZNF254 Gene

SOURCE GeneReport for Unigene cluster for ZNF254 Gene Hs.729302

genes like me logo Genes that share expressions with ZNF254: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for ZNF254 Gene

Orthologs for ZNF254 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF254 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF254 35
  • 99.44 (n)
  • 98.79 (a)
ZNF254 36
  • 99 (a)
(Bos Taurus)
Mammalia -- 36
  • 56 (a)
(Canis familiaris)
Mammalia -- 36
  • 39 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 41 (a)
-- 36
  • 51 (a)
(Mus musculus)
Mammalia Zfp493 36
  • 59 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 53 (a)
-- 36
  • 39 (a)
-- 36
  • 45 (a)
-- 36
  • 41 (a)
-- 36
  • 36 (a)
-- 36
  • 35 (a)
-- 36
  • 34 (a)
-- 36
  • 30 (a)
Species with no ortholog for ZNF254:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF254 Gene

Gene Tree for ZNF254 (if available)
Gene Tree for ZNF254 (if available)

Paralogs for ZNF254 Gene

(565) SIMAP similar genes for ZNF254 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZNF254: view

Variants for ZNF254 Gene

Sequence variations from dbSNP and Humsavar for ZNF254 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs171657 -- 23,862,941(+) gctct(C/G)ttgtc intron-variant
rs251743 -- 23,873,566(-) CTGGC(C/T)TTTAG intron-variant
rs251744 -- 23,872,100(+) AGAAG(C/T)GATTA intron-variant
rs251745 -- 23,868,517(-) ccctt(C/T)ttttt intron-variant
rs251746 -- 23,867,246(+) tctcc(A/T)catcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF254 Gene

Variant ID Type Subtype PubMed ID
esv2751784 CNV Gain 17911159
nsv524183 CNV Gain 19592680
dgv3821n71 CNV Gain 21882294
esv2662304 CNV Deletion 23128226
nsv833791 CNV Loss 17160897
dgv3822n71 CNV Gain 21882294
nsv833793 CNV Gain+Loss 17160897
dgv3823n71 CNV Gain 21882294
nsv911480 CNV Gain 21882294

Relevant External Links for ZNF254 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF254 Gene

Disorders for ZNF254 Gene

No disorders were found for ZNF254 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for ZNF254 Gene

Publications for ZNF254 Gene

  1. Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full- length cDNA cloning. (PMID: 9653160) Mao M. … Chen Z. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4
  2. Molecular cloning of six novel Kruppel-like zinc finger genes from hematopoietic cells and identification of a novel transregulatory domain KRNB. (PMID: 10585455) Han Z.-G. … Chen Z. (J. Biol. Chem. 1999) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Biomarkers of human cutaneous squamous cell carcinoma from tissues and cell lines identified by DNA microarrays and qRT-PCR. (PMID: 12821146) Dooley T.P. … Davis R.L. (Biochem. Biophys. Res. Commun. 2003) 3 23
  5. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3

Products for ZNF254 Gene

Sources for ZNF254 Gene

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