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Aliases for ZNF254 Gene

Aliases for ZNF254 Gene

  • Zinc Finger Protein 254 2 3 5
  • Zinc Finger Protein 539 2 3 4
  • Hematopoietic Cell-Derived Zinc Finger Protein 1 3 4
  • Bone Marrow Zinc Finger 5 3 4
  • HD-ZNF1 3 4
  • ZNF91L 3 4
  • ZNF539 3 4
  • BMZF-5 3 4
  • Zinc Finger Protein 91-Like 4
  • CTD-2017D11.1 3
  • BMZF5 4

External Ids for ZNF254 Gene

Previous HGNC Symbols for ZNF254 Gene

  • ZNF91L
  • ZNF539

Previous GeneCards Identifiers for ZNF254 Gene

  • GC19U990156
  • GC19P024605
  • GC19P023992
  • GC19P024061
  • GC19P024048
  • GC19P024269
  • GC19P023824
  • GC19P024217
  • GC19P023833

Summaries for ZNF254 Gene

Entrez Gene Summary for ZNF254 Gene

  • Zinc finger proteins have been shown to interact with nucleic acids and to have diverse functions. The zinc finger domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines that are involved in coordinating zinc. Kruppel-related proteins form 1 family of zinc finger proteins. See ZFP93 (MIM 604749) for additional information on zinc finger proteins.[supplied by OMIM, Jul 2002]

GeneCards Summary for ZNF254 Gene

ZNF254 (Zinc Finger Protein 254) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF726.

UniProtKB/Swiss-Prot for ZNF254 Gene

  • May be involved in transcriptional regulation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF254 Gene

Genomics for ZNF254 Gene

Regulatory Elements for ZNF254 Gene

Enhancers for ZNF254 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ZNF254 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF254 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF254 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF254 Gene

Chromosome:
19
Start:
24,033,405 bp from pter
End:
24,129,968 bp from pter
Size:
96,564 bases
Orientation:
Plus strand

Genomic View for ZNF254 Gene

Genes around ZNF254 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF254 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF254 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF254 Gene

Proteins for ZNF254 Gene

  • Protein details for ZNF254 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75437-ZN254_HUMAN
    Recommended name:
    Zinc finger protein 254
    Protein Accession:
    O75437
    Secondary Accessions:
    • A4QPC0
    • Q86XL7

    Protein attributes for ZNF254 Gene

    Size:
    659 amino acids
    Molecular mass:
    77160 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF254 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF254 Gene

Post-translational modifications for ZNF254 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF254 Gene

Domains & Families for ZNF254 Gene

Gene Families for ZNF254 Gene

Protein Domains for ZNF254 Gene

Suggested Antigen Peptide Sequences for ZNF254 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75437

UniProtKB/Swiss-Prot:

ZN254_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 15 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 15 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF254: view

Function for ZNF254 Gene

Molecular function for ZNF254 Gene

GENATLAS Biochemistry:
zinc finger protein254
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF254 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF254: view
genes like me logo Genes that share phenotypes with ZNF254: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF254 Gene

Localization for ZNF254 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF254 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF254 Gene COMPARTMENTS Subcellular localization image for ZNF254 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF254 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF254: view

Pathways & Interactions for ZNF254 Gene

SuperPathways for ZNF254 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF254: view

Pathways by source for ZNF254 Gene

2 Reactome pathways for ZNF254 Gene

Gene Ontology (GO) - Biological Process for ZNF254 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS 10585455
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF254: view

No data available for SIGNOR curated interactions for ZNF254 Gene

Drugs & Compounds for ZNF254 Gene

No Compound Related Data Available

Transcripts for ZNF254 Gene

Unigene Clusters for ZNF254 Gene

Zinc finger protein 254:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF254 Gene

No ASD Table

Relevant External Links for ZNF254 Gene

GeneLoc Exon Structure for
ZNF254
ECgene alternative splicing isoforms for
ZNF254

Expression for ZNF254 Gene

mRNA expression in normal human tissues for ZNF254 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF254 Gene:

ZNF254

SOURCE GeneReport for Unigene cluster for ZNF254 Gene:

Hs.729302
genes like me logo Genes that share expression patterns with ZNF254: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ZNF254 Gene

Orthologs for ZNF254 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF254 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF254 34
  • 99.44 (n)
  • 98.79 (a)
ZNF254 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 35
  • 56 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 39 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 41 (a)
ManyToMany
-- 35
  • 51 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Zfp493 35
  • 59 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 53 (a)
ManyToMany
-- 35
  • 39 (a)
ManyToMany
-- 35
  • 45 (a)
ManyToMany
-- 35
  • 41 (a)
ManyToMany
-- 35
  • 36 (a)
ManyToMany
-- 35
  • 35 (a)
ManyToMany
-- 35
  • 34 (a)
ManyToMany
-- 35
  • 30 (a)
ManyToMany
Species where no ortholog for ZNF254 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF254 Gene

ENSEMBL:
Gene Tree for ZNF254 (if available)
TreeFam:
Gene Tree for ZNF254 (if available)

Paralogs for ZNF254 Gene

(565) SIMAP similar genes for ZNF254 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZNF254: view

Variants for ZNF254 Gene

Sequence variations from dbSNP and Humsavar for ZNF254 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs17854260 - 24,126,278(+) TCAAG(A/G)CCTTT reference, missense
VAR_047462 -
rs2925930 - 24,127,369(-) TCTAG(C/T)ATGAA reference, missense
rs2446056 - 24,127,780(-) AATTA(C/T)CTTAT reference, missense
rs12611425 - 24,127,611(+) CATAA(A/C/G)ATAAT reference, synonymous-codon, missense

Structural Variations from Database of Genomic Variants (DGV) for ZNF254 Gene

Variant ID Type Subtype PubMed ID
dgv3481n100 CNV gain 25217958
dgv657e214 CNV loss 21293372
esv2662304 CNV deletion 23128226
esv2670676 CNV deletion 23128226
esv2751784 CNV gain 17911159
esv3428234 OTHER inversion 20981092
esv3556222 CNV deletion 23714750
esv3583316 CNV loss 25503493
esv3644032 CNV loss 21293372
esv3644033 CNV gain 21293372
esv3644035 CNV loss 21293372
esv3644036 CNV gain 21293372
esv3644038 CNV gain 21293372
esv3644039 CNV gain 21293372
esv3644040 CNV loss 21293372
esv3644041 CNV loss 21293372
esv3644042 CNV gain 21293372
esv3644043 CNV loss 21293372
esv3644045 CNV gain 21293372
esv3893187 CNV gain 25118596
esv993002 CNV insertion 20482838
nsv1057291 CNV loss 25217958
nsv1057420 CNV gain 25217958
nsv1062848 CNV loss 25217958
nsv1109183 CNV deletion 24896259
nsv1134778 CNV deletion 24896259
nsv1147498 CNV deletion 26484159
nsv479744 CNV novel sequence insertion 20440878
nsv524183 CNV gain 19592680
nsv579077 CNV gain 21841781
nsv579078 CNV gain 21841781
nsv579079 CNV loss 21841781
nsv833791 CNV loss 17160897
nsv833793 CNV gain+loss 17160897
nsv961203 CNV duplication 23825009
nsv978798 CNV duplication 23825009

Variation tolerance for ZNF254 Gene

Residual Variation Intolerance Score: 95.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.45; 77.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF254 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF254

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF254 Gene

Disorders for ZNF254 Gene

Relevant External Links for ZNF254

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF254

No disorders were found for ZNF254 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF254 Gene

Publications for ZNF254 Gene

  1. Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full- length cDNA cloning. (PMID: 9653160) Mao M. … Chen Z. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4 65
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  3. Biomarkers of human cutaneous squamous cell carcinoma from tissues and cell lines identified by DNA microarrays and qRT-PCR. (PMID: 12821146) Dooley T.P. … Davis R.L. (Biochem. Biophys. Res. Commun. 2003) 3 22 65
  4. Molecular cloning of six novel Kruppel-like zinc finger genes from hematopoietic cells and identification of a novel transregulatory domain KRNB. (PMID: 10585455) Han Z.-G. … Chen Z. (J. Biol. Chem. 1999) 3 4 65
  5. Genetic association with overall survival of taxane-treated lung cancer patients - a genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study. (PMID: 23006423) Niu N. … Wang L. (BMC Cancer 2012) 3 65

Products for ZNF254 Gene

Sources for ZNF254 Gene

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