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Aliases for ZNF254 Gene

Aliases for ZNF254 Gene

  • Zinc Finger Protein 254 2 3
  • Zinc Finger Protein 539 2 3 4
  • Hematopoietic Cell-Derived Zinc Finger Protein 1 3 4
  • Bone Marrow Zinc Finger 5 3 4
  • HD-ZNF1 3 4
  • ZNF91L 3 4
  • ZNF539 3 4
  • BMZF-5 3 4
  • Zinc Finger Protein 91-Like 4
  • CTD-2017D11.1 3
  • BMZF5 4

External Ids for ZNF254 Gene

Previous HGNC Symbols for ZNF254 Gene

  • ZNF91L
  • ZNF539

Previous GeneCards Identifiers for ZNF254 Gene

  • GC19U990156
  • GC19P024605
  • GC19P023992
  • GC19P024061
  • GC19P024048
  • GC19P024269
  • GC19P023824
  • GC19P024217
  • GC19P023833

Summaries for ZNF254 Gene

Entrez Gene Summary for ZNF254 Gene

  • Zinc finger proteins have been shown to interact with nucleic acids and to have diverse functions. The zinc finger domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines that are involved in coordinating zinc. Kruppel-related proteins form 1 family of zinc finger proteins. See ZFP93 (MIM 604749) for additional information on zinc finger proteins.[supplied by OMIM, Jul 2002]

GeneCards Summary for ZNF254 Gene

ZNF254 (Zinc Finger Protein 254) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF253.

UniProtKB/Swiss-Prot for ZNF254 Gene

  • May be involved in transcriptional regulation

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF254 Gene

Genomics for ZNF254 Gene

Genomic Location for ZNF254 Gene

Chromosome:
19
Start:
24,033,405 bp from pter
End:
24,129,968 bp from pter
Size:
96,564 bases
Orientation:
Plus strand

Genomic View for ZNF254 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF254 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF254 Gene

No data available for Regulatory Elements for ZNF254 Gene

Proteins for ZNF254 Gene

  • Protein details for ZNF254 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75437-ZN254_HUMAN
    Recommended name:
    Zinc finger protein 254
    Protein Accession:
    O75437
    Secondary Accessions:
    • A4QPC0
    • Q86XL7

    Protein attributes for ZNF254 Gene

    Size:
    659 amino acids
    Molecular mass:
    77160 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF254 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF254 Gene

Proteomics data for ZNF254 Gene at MOPED

Post-translational modifications for ZNF254 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF254 Gene

Domains & Families for ZNF254 Gene

Gene Families for ZNF254 Gene

Protein Domains for ZNF254 Gene

Suggested Antigen Peptide Sequences for ZNF254 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75437

UniProtKB/Swiss-Prot:

ZN254_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 15 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 15 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF254: view

Function for ZNF254 Gene

Molecular function for ZNF254 Gene

GENATLAS Biochemistry:
zinc finger protein254
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF254 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF254: view
genes like me logo Genes that share phenotypes with ZNF254: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF254 Gene

Localization for ZNF254 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF254 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF254 Gene COMPARTMENTS Subcellular localization image for ZNF254 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for ZNF254 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF254: view

Pathways & Interactions for ZNF254 Gene

SuperPathways for ZNF254 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF254: view

Pathways by source for ZNF254 Gene

2 Reactome pathways for ZNF254 Gene

Interacting Proteins for ZNF254 Gene

Gene Ontology (GO) - Biological Process for ZNF254 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS 10585455
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
genes like me logo Genes that share ontologies with ZNF254: view

No data available for SIGNOR curated interactions for ZNF254 Gene

Drugs & Compounds for ZNF254 Gene

No Compound Related Data Available

Transcripts for ZNF254 Gene

Unigene Clusters for ZNF254 Gene

Zinc finger protein 254:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF254

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF254 Gene

No ASD Table

Relevant External Links for ZNF254 Gene

GeneLoc Exon Structure for
ZNF254
ECgene alternative splicing isoforms for
ZNF254

Expression for ZNF254 Gene

mRNA expression in normal human tissues for ZNF254 Gene

SOURCE GeneReport for Unigene cluster for ZNF254 Gene Hs.729302

genes like me logo Genes that share expression patterns with ZNF254: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZNF254 Gene

Orthologs for ZNF254 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF254 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF254 35
  • 99.44 (n)
  • 98.79 (a)
ZNF254 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 56 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 39 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 41 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Zfp493 36
  • 59 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 53 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
-- 36
  • 36 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
-- 36
  • 34 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
Species with no ortholog for ZNF254:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF254 Gene

ENSEMBL:
Gene Tree for ZNF254 (if available)
TreeFam:
Gene Tree for ZNF254 (if available)

Paralogs for ZNF254 Gene

(565) SIMAP similar genes for ZNF254 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZNF254: view

Variants for ZNF254 Gene

Sequence variations from dbSNP and Humsavar for ZNF254 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs888314 -- 24,056,884(+) cagag(A/C)agttt intron-variant
rs888315 -- 24,056,986(+) TAGGC(A/G)CAATG intron-variant
rs888316 -- 24,057,208(+) TGCCA(A/G)TTGTT intron-variant
rs1079564 -- 24,043,218(+) AATAT(A/G)TCATC intron-variant
rs1129445 -- 24,100,205(+) gacca(G/T)ggagc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF254 Gene

Variant ID Type Subtype PubMed ID
esv2751784 CNV Gain 17911159
nsv524183 CNV Gain 19592680
dgv3821n71 CNV Gain 21882294
esv2662304 CNV Deletion 23128226
nsv833791 CNV Loss 17160897
dgv3822n71 CNV Gain 21882294
nsv833793 CNV Gain+Loss 17160897
dgv3823n71 CNV Gain 21882294
nsv911480 CNV Gain 21882294

Variation tolerance for ZNF254 Gene

Residual Variation Intolerance Score: 95.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.45; 77.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF254 Gene

HapMap Linkage Disequilibrium report
ZNF254

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF254 Gene

Disorders for ZNF254 Gene

Relevant External Links for ZNF254

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF254
genes like me logo Genes that share disorders with ZNF254: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF254 Gene

Publications for ZNF254 Gene

  1. Biomarkers of human cutaneous squamous cell carcinoma from tissues and cell lines identified by DNA microarrays and qRT-PCR. (PMID: 12821146) Dooley T.P. … Davis R.L. (Biochem. Biophys. Res. Commun. 2003) 23 67
  2. Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full- length cDNA cloning. (PMID: 9653160) Mao M. … Chen Z. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 67
  3. Genetic association with overall survival of taxane-treated lung cancer patients - a genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study. (PMID: 23006423) Niu N. … Wang L. (BMC Cancer 2012) 67
  4. Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication. (PMID: 18854154) KAPnig R. … Chanda S.K. (Cell 2008) 67
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 67

Products for ZNF254 Gene

Sources for ZNF254 Gene

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