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Aliases for ZNF253 Gene

Aliases for ZNF253 Gene

  • Zinc Finger Protein 253 2 3 5
  • Zinc Finger Protein 411 2 3 4
  • Bone Marrow Zinc Finger 1 3 4
  • ZNF411 3 4
  • BMZF-1 3 4
  • BMZF1 3 4
  • DNA-Binding Protein 3

External Ids for ZNF253 Gene

Previous HGNC Symbols for ZNF253 Gene

  • ZNF411

Previous GeneCards Identifiers for ZNF253 Gene

  • GC19U990224
  • GC19P020380
  • GC19P019821
  • GC19P019850
  • GC19P019978

Summaries for ZNF253 Gene

GeneCards Summary for ZNF253 Gene

ZNF253 (Zinc Finger Protein 253) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF737.

UniProtKB/Swiss-Prot for ZNF253 Gene

  • May function as a transcription factor. Seem to have a transcriptional repression activity.

Additional gene information for ZNF253 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF253 Gene

Genomics for ZNF253 Gene

Regulatory Elements for ZNF253 Gene

Enhancers for ZNF253 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H019374 1.4 Ensembl ENCODE dbSUPER 31.9 -490.7 -490668 0 ZNF493 ZBTB40 ZNF155 ZNF138 ZNF354C SCRT2 KLF7 ZNF202 ZC3H11A OVOL3 NR2C2AP ATP13A1 ENSG00000268030 ZNF90 UPF1 ENSG00000267481 MAU2 ENSG00000268938 ZNF253 SUGP2
GH19H019865 1.4 FANTOM5 ENCODE 8.6 +0.9 894 3 PKNOX1 ATF1 ARID4B DMAP1 YY1 ETS1 ZNF766 GATA2 ZNF143 ZNF207 ZNF93 ZNF506 ATP13A1 MEF2B NR2C2AP GATAD2A ZNF14 PBX4 ZNF253 VN1R77P
GH19H019550 0.8 ENCODE 9.8 -315.2 -315218 1 PKNOX1 ESRRA NFIB SIN3A ZIC2 RFX5 ZEB1 ZKSCAN1 ZFHX2 CTBP1 ZNF253 GC19M019560 CILP2
GH19H019549 0.6 ENCODE 9.8 -316.5 -316464 0 ZFP3 HLF CEBPB RCOR1 MYC ZBTB7B EGR2 ZNF253 CILP2 GC19M019560
GH19H020051 1.6 FANTOM5 Ensembl ENCODE 1.3 +186.5 186507 1 ELF3 ATF1 SIN3A ZNF76 DMAP1 RAD21 RFX5 YY1 ETS1 ZNF143 ZNF682 ZNF253 ZNF506 LOC105372309 GC19M022149
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF253 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF253 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000108295 770 2401 PKNOX1 ATF1 ARID4B DMAP1 YY1 ETS1 ZNF766 GATA2 ZNF143 ZNF207

Genomic Location for ZNF253 Gene

Chromosome:
19
Start:
19,865,830 bp from pter
End:
19,894,674 bp from pter
Size:
28,845 bases
Orientation:
Plus strand

Genomic View for ZNF253 Gene

Genes around ZNF253 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF253 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF253 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF253 Gene

Proteins for ZNF253 Gene

  • Protein details for ZNF253 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75346-ZN253_HUMAN
    Recommended name:
    Zinc finger protein 253
    Protein Accession:
    O75346
    Secondary Accessions:
    • A4FVA7
    • Q0P6G3
    • Q6P0L2
    • Q8NCA3
    • Q8NCF9

    Protein attributes for ZNF253 Gene

    Size:
    499 amino acids
    Molecular mass:
    57602 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH14148.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11257.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF253 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF253 Gene

Post-translational modifications for ZNF253 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF253 Gene

No data available for DME Specific Peptides for ZNF253 Gene

Domains & Families for ZNF253 Gene

Gene Families for ZNF253 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF253 Gene

Suggested Antigen Peptide Sequences for ZNF253 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75346

UniProtKB/Swiss-Prot:

ZN253_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF253: view

Function for ZNF253 Gene

Molecular function for ZNF253 Gene

UniProtKB/Swiss-Prot Function:
May function as a transcription factor. Seem to have a transcriptional repression activity.

Gene Ontology (GO) - Molecular Function for ZNF253 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 15670815
GO:0008270 zinc ion binding NAS 10585455
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF253: view
genes like me logo Genes that share phenotypes with ZNF253: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZNF253
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF253 Gene

Localization for ZNF253 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF253 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF253 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for ZNF253 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF253: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF253 Gene

Pathways & Interactions for ZNF253 Gene

SuperPathways for ZNF253 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF253: view

Pathways by source for ZNF253 Gene

2 Reactome pathways for ZNF253 Gene

Gene Ontology (GO) - Biological Process for ZNF253 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,NAS 10585455
GO:0045892 negative regulation of transcription, DNA-templated NAS 10585455
genes like me logo Genes that share ontologies with ZNF253: view

No data available for SIGNOR curated interactions for ZNF253 Gene

Drugs & Compounds for ZNF253 Gene

No Compound Related Data Available

Transcripts for ZNF253 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZNF253
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF253 Gene

No ASD Table

Relevant External Links for ZNF253 Gene

GeneLoc Exon Structure for
ZNF253
ECgene alternative splicing isoforms for
ZNF253

Expression for ZNF253 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF253 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF253 Gene:

ZNF253

mRNA Expression by UniProt/SwissProt for ZNF253 Gene:

O75346-ZN253_HUMAN
Tissue specificity: Expressed in bone marrow and in monocytic and immature erythroid cell lines.

Evidence on tissue expression from TISSUES for ZNF253 Gene

  • Bone marrow(4)
  • Eye(4)
genes like me logo Genes that share expression patterns with ZNF253: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF253 Gene

Orthologs for ZNF253 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF253 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF253 33 34
  • 99.1 (n)
mouse
(Mus musculus)
Mammalia Zfp65 33 16
  • 67.43 (n)
Zfp386 34
  • 33 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 49 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 49 (a)
ManyToMany
-- 34
  • 34 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 34 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 48 (a)
ManyToMany
-- 34
  • 38 (a)
ManyToMany
-- 34
  • 35 (a)
ManyToMany
-- 34
  • 31 (a)
ManyToMany
-- 34
  • 29 (a)
ManyToMany
-- 34
  • 28 (a)
ManyToMany
-- 34
  • 28 (a)
ManyToMany
-- 34
  • 27 (a)
ManyToMany
Species where no ortholog for ZNF253 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF253 Gene

ENSEMBL:
Gene Tree for ZNF253 (if available)
TreeFam:
Gene Tree for ZNF253 (if available)

Paralogs for ZNF253 Gene

(541) SIMAP similar genes for ZNF253 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF253: view

Variants for ZNF253 Gene

Sequence variations from dbSNP and Humsavar for ZNF253 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000044464 -- 19,875,702(+) TAAAC(-/TCTT)TCTTT intron-variant
rs1000056028 -- 19,874,637(+) CCGGG(C/T)GCAGT intron-variant
rs1000106540 -- 19,874,432(+) GTCAA(A/C)AGAAC intron-variant
rs1000182983 -- 19,892,079(+) TAGTT(C/T)ATACT reference, missense
rs1000199579 -- 19,882,797(+) AAACC(C/T)TGTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF253 Gene

Variant ID Type Subtype PubMed ID
dgv3456n100 CNV gain 25217958
dgv509e201 CNV deletion 23290073
esv2259143 CNV deletion 18987734
esv2718296 CNV deletion 23290073
esv2718298 CNV deletion 23290073
esv2718299 CNV deletion 23290073
esv3643860 CNV loss 21293372
esv3893169 CNV loss 25118596
nsv1061846 CNV loss 25217958
nsv1066792 CNV gain 25217958
nsv138332 CNV deletion 16902084
nsv519535 CNV gain 19592680
nsv961192 CNV duplication 23825009

Variation tolerance for ZNF253 Gene

Residual Variation Intolerance Score: 59.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.96; 19.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF253 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF253

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF253 Gene

Disorders for ZNF253 Gene

Relevant External Links for ZNF253

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF253

No disorders were found for ZNF253 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF253 Gene

Publications for ZNF253 Gene

  1. Molecular cloning of six novel Krüppel-like zinc finger genes from hematopoietic cells and identification of a novel transregulatory domain KRNB. (PMID: 10585455) Han ZG … Chen Z (The Journal of biological chemistry 1999) 2 3 4 60
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 60
  3. LDOC1, a novel MZF-1-interacting protein, induces apoptosis. (PMID: 15670815) Inoue M … Ra C (FEBS letters 2005) 3 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 60
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 60

Products for ZNF253 Gene

Sources for ZNF253 Gene

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