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Aliases for ZNF253 Gene

Aliases for ZNF253 Gene

  • Zinc Finger Protein 253 2 3
  • Zinc Finger Protein 411 2 3 4
  • Bone Marrow Zinc Finger 1 3 4
  • ZNF411 3 4
  • BMZF-1 3 4
  • BMZF1 3 4
  • DNA-Binding Protein 3

External Ids for ZNF253 Gene

Previous HGNC Symbols for ZNF253 Gene

  • ZNF411

Previous GeneCards Identifiers for ZNF253 Gene

  • GC19U990224
  • GC19P020380
  • GC19P019821
  • GC19P019850
  • GC19P019978

Summaries for ZNF253 Gene

GeneCards Summary for ZNF253 Gene

ZNF253 (Zinc Finger Protein 253) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF681.

UniProtKB/Swiss-Prot for ZNF253 Gene

  • May function as a transcription factor. Seem to have a transcriptional repression activity

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF253 Gene

Genomics for ZNF253 Gene

Regulatory Elements for ZNF253 Gene

Genomic Location for ZNF253 Gene

19,865,886 bp from pter
19,894,674 bp from pter
28,789 bases
Plus strand

Genomic View for ZNF253 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF253 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF253 Gene

Proteins for ZNF253 Gene

  • Protein details for ZNF253 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 253
    Protein Accession:
    Secondary Accessions:
    • A4FVA7
    • Q0P6G3
    • Q6P0L2
    • Q8NCA3
    • Q8NCF9

    Protein attributes for ZNF253 Gene

    499 amino acids
    Molecular mass:
    57602 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH14148.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11257.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF253 Gene


neXtProt entry for ZNF253 Gene

Proteomics data for ZNF253 Gene at MOPED

Post-translational modifications for ZNF253 Gene

  • Ubiquitination at Lys263
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF253 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF253 Gene

Domains for ZNF253 Gene

Gene Families for ZNF253 Gene

  • ZNF :Zinc fingers, C2H2-type

Suggested Antigen Peptide Sequences for ZNF253 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • O75346
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 11 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF253: view

Function for ZNF253 Gene

Molecular function for ZNF253 Gene

UniProtKB/Swiss-Prot Function: May function as a transcription factor. Seem to have a transcriptional repression activity

Gene Ontology (GO) - Molecular Function for ZNF253 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0008270 zinc ion binding NAS 10585455
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with ZNF253: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF253 Gene

Localization for ZNF253 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF253 Gene

Subcellular locations from

Jensen Localization Image for ZNF253 Gene COMPARTMENTS Subcellular localization image for ZNF253 gene
Compartment Confidence
nucleus 5
golgi apparatus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF253 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF253: view

Pathways for ZNF253 Gene

SuperPathways for ZNF253 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF253: view

Pathways by source for ZNF253 Gene

2 Reactome pathways for ZNF253 Gene

Gene Ontology (GO) - Biological Process for ZNF253 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 10585455
GO:0045892 negative regulation of transcription, DNA-templated NAS 10585455
genes like me logo Genes that share ontologies with ZNF253: view

Transcripts for ZNF253 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF253 Gene

No ASD Table

Relevant External Links for ZNF253 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF253 Gene

mRNA expression in normal human tissues for ZNF253 Gene

mRNA Expression by UniProt/SwissProt for ZNF253 Gene

Tissue specificity: Expressed in bone marrow and in monocytic and immature erythroid cell lines
genes like me logo Genes that share expressions with ZNF253: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein expression for ZNF253 Gene

Orthologs for ZNF253 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF253 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF253 35
  • 99.1 (n)
  • 98.65 (a)
ZNF253 36
  • 99 (a)
(Bos Taurus)
Mammalia -- 36
  • 49 (a)
(Canis familiaris)
Mammalia -- 36
  • 34 (a)
(Mus musculus)
Mammalia Zfp386 36
  • 33 (a)
Zfp65 35
  • 67.43 (n)
  • 57.65 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 34 (a)
-- 36
  • 49 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 48 (a)
-- 36
  • 31 (a)
-- 36
  • 38 (a)
-- 36
  • 35 (a)
-- 36
  • 28 (a)
-- 36
  • 29 (a)
-- 36
  • 28 (a)
-- 36
  • 27 (a)
Species with no ortholog for ZNF253:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF253 Gene

Gene Tree for ZNF253 (if available)
Gene Tree for ZNF253 (if available)

Paralogs for ZNF253 Gene

Selected SIMAP similar genes for ZNF253 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF253: view

Variants for ZNF253 Gene

Sequence variations from dbSNP and Humsavar for ZNF253 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1061560 -- 19,893,618(+) AAAAA(C/T)TGTGC downstream-variant-500B
rs2060238 -- 19,888,350(-) gcagt(C/T)gctca intron-variant
rs2060239 -- 19,888,199(-) ataat(A/C)ccagc intron-variant
rs2116888 -- 19,867,948(-) tcatc(A/G)ctaat intron-variant
rs2304169 -- 19,865,892(-) AACAC(A/T)GAGGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNF253 Gene

Variant ID Type Subtype PubMed ID
dgv3791n71 CNV Loss 21882294
nsv519535 CNV Gain 19592680
esv2718296 CNV Deletion 23290073
dgv550e201 CNV Deletion 23290073
dgv3792n71 CNV Gain 21882294
esv2718298 CNV Deletion 23290073
esv2259143 CNV Deletion 18987734
nsv138332 CNV Loss 16902084
esv2718299 CNV Deletion 23290073

Relevant External Links for ZNF253 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF253 Gene

Disorders for ZNF253 Gene

(1) University of Copenhagen DISEASES for ZNF253 Gene

genes like me logo Genes that share disorders with ZNF253: view

No data available for UniProtKB/Swiss-Prot for ZNF253 Gene

Publications for ZNF253 Gene

  1. Molecular cloning of six novel Kruppel-like zinc finger genes from hematopoietic cells and identification of a novel transregulatory domain KRNB. (PMID: 10585455) Han Z.-G. … Chen Z. (J. Biol. Chem. 1999) 2 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PMID: 22505724) Udeshi N.D. … Carr S.A. (Mol. Cell Proteomics 2012) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4

Products for ZNF253 Gene

Sources for ZNF253 Gene

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