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Aliases for ZNF253 Gene

Aliases for ZNF253 Gene

  • Zinc Finger Protein 253 2 3
  • Zinc Finger Protein 411 2 3 4
  • Bone Marrow Zinc Finger 1 3 4
  • ZNF411 3 4
  • BMZF-1 3 4
  • BMZF1 3 4
  • DNA-Binding Protein 3

External Ids for ZNF253 Gene

Previous HGNC Symbols for ZNF253 Gene

  • ZNF411

Previous GeneCards Identifiers for ZNF253 Gene

  • GC19U990224
  • GC19P020380
  • GC19P019821
  • GC19P019850
  • GC19P019978

Summaries for ZNF253 Gene

GeneCards Summary for ZNF253 Gene

ZNF253 (Zinc Finger Protein 253) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF681.

UniProtKB/Swiss-Prot for ZNF253 Gene

  • May function as a transcription factor. Seem to have a transcriptional repression activity

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF253 Gene

Genomics for ZNF253 Gene

Regulatory Elements for ZNF253 Gene

Genomic Location for ZNF253 Gene

Chromosome:
19
Start:
19,865,830 bp from pter
End:
19,894,674 bp from pter
Size:
28,845 bases
Orientation:
Plus strand

Genomic View for ZNF253 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for ZNF253 Gene

Proteins for ZNF253 Gene

  • Protein details for ZNF253 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75346-ZN253_HUMAN
    Recommended name:
    Zinc finger protein 253
    Protein Accession:
    O75346
    Secondary Accessions:
    • A4FVA7
    • Q0P6G3
    • Q6P0L2
    • Q8NCA3
    • Q8NCF9

    Protein attributes for ZNF253 Gene

    Size:
    499 amino acids
    Molecular mass:
    57602 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH14148.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11257.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF253 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF253 Gene

Proteomics data for ZNF253 Gene at MOPED

Post-translational modifications for ZNF253 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF253 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF253 Gene

Domains & Families for ZNF253 Gene

Gene Families for ZNF253 Gene

Protein Domains for ZNF253 Gene

Suggested Antigen Peptide Sequences for ZNF253 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75346

UniProtKB/Swiss-Prot:

ZN253_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 11 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 11 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF253: view

Function for ZNF253 Gene

Molecular function for ZNF253 Gene

UniProtKB/Swiss-Prot Function:
May function as a transcription factor. Seem to have a transcriptional repression activity

Gene Ontology (GO) - Molecular Function for ZNF253 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IBA --
GO:0003676 nucleic acid binding --
GO:0008270 zinc ion binding NAS 10585455
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with ZNF253: view

Phenotypes for ZNF253 Gene

genes like me logo Genes that share phenotypes with ZNF253: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF253

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF253 Gene

Localization for ZNF253 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF253 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF253 Gene COMPARTMENTS Subcellular localization image for ZNF253 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for ZNF253 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with ZNF253: view

Pathways & Interactions for ZNF253 Gene

SuperPathways for ZNF253 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF253: view

Pathways by source for ZNF253 Gene

2 Reactome pathways for ZNF253 Gene

Gene Ontology (GO) - Biological Process for ZNF253 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 10585455
GO:0045892 negative regulation of transcription, DNA-templated NAS 10585455
genes like me logo Genes that share ontologies with ZNF253: view

No data available for SIGNOR curated interactions for ZNF253 Gene

Drugs & Compounds for ZNF253 Gene

No Compound Related Data Available

Transcripts for ZNF253 Gene

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF253

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF253 Gene

No ASD Table

Relevant External Links for ZNF253 Gene

GeneLoc Exon Structure for
ZNF253
ECgene alternative splicing isoforms for
ZNF253

Expression for ZNF253 Gene

mRNA expression in normal human tissues for ZNF253 Gene

mRNA Expression by UniProt/SwissProt for ZNF253 Gene

O75346-ZN253_HUMAN
Tissue specificity: Expressed in bone marrow and in monocytic and immature erythroid cell lines
genes like me logo Genes that share expression patterns with ZNF253: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for ZNF253 Gene

Orthologs for ZNF253 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF253 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Zfp65 35
  • 67.43 (n)
  • 57.65 (a)
Zfp386 36
  • 33 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia ZNF253 35
  • 99.1 (n)
  • 98.65 (a)
ZNF253 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 49 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 34 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 34 (a)
ManyToMany
-- 36
  • 49 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 48 (a)
ManyToMany
-- 36
  • 31 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 29 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 27 (a)
ManyToMany
Species with no ortholog for ZNF253:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF253 Gene

ENSEMBL:
Gene Tree for ZNF253 (if available)
TreeFam:
Gene Tree for ZNF253 (if available)

Paralogs for ZNF253 Gene

(541) SIMAP similar genes for ZNF253 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF253: view

Variants for ZNF253 Gene

Sequence variations from dbSNP and Humsavar for ZNF253 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1061560 -- 19,893,618(+) AAAAA(C/T)TGTGC downstream-variant-500B, utr-variant-3-prime
rs2060238 -- 19,888,350(-) gcagt(C/T)gctca intron-variant
rs2060239 -- 19,888,199(-) ataat(A/C)ccagc intron-variant
rs2335365 -- 19,887,333(+) ctctt(G/T)ttgct intron-variant
rs2335366 -- 19,887,448(+) tctgc(C/T)accac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF253 Gene

Variant ID Type Subtype PubMed ID
dgv3791n71 CNV Loss 21882294
nsv519535 CNV Gain 19592680
esv2718296 CNV Deletion 23290073
dgv550e201 CNV Deletion 23290073
dgv3792n71 CNV Gain 21882294
esv2718298 CNV Deletion 23290073
esv2259143 CNV Deletion 18987734
nsv138332 CNV Loss 16902084
esv2718299 CNV Deletion 23290073

Variation tolerance for ZNF253 Gene

Residual Variation Intolerance Score: 59.59% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.96; 19.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF253 Gene

HapMap Linkage Disequilibrium report
ZNF253

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF253 Gene

Disorders for ZNF253 Gene

Relevant External Links for ZNF253

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF253
genes like me logo Genes that share disorders with ZNF253: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF253 Gene

Publications for ZNF253 Gene

  1. Molecular cloning of six novel Kruppel-like zinc finger genes from hematopoietic cells and identification of a novel transregulatory domain KRNB. (PMID: 10585455) Han Z.-G. … Chen Z. (J. Biol. Chem. 1999) 2 67
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 67
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 67

Products for ZNF253 Gene

Sources for ZNF253 Gene

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