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Aliases for ZNF253 Gene

Aliases for ZNF253 Gene

  • Zinc Finger Protein 253 2 3 5
  • Zinc Finger Protein 411 2 3 4
  • Bone Marrow Zinc Finger 1 3 4
  • ZNF411 3 4
  • BMZF-1 3 4
  • BMZF1 3 4
  • DNA-Binding Protein 3

External Ids for ZNF253 Gene

Previous HGNC Symbols for ZNF253 Gene

  • ZNF411

Previous GeneCards Identifiers for ZNF253 Gene

  • GC19U990224
  • GC19P020380
  • GC19P019821
  • GC19P019850
  • GC19P019978

Summaries for ZNF253 Gene

GeneCards Summary for ZNF253 Gene

ZNF253 (Zinc Finger Protein 253) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF718.

UniProtKB/Swiss-Prot for ZNF253 Gene

  • May function as a transcription factor. Seem to have a transcriptional repression activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF253 Gene

Genomics for ZNF253 Gene

Regulatory Elements for ZNF253 Gene

Enhancers for ZNF253 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF253 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF253 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF253 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF253 Gene

19,865,830 bp from pter
19,894,674 bp from pter
28,845 bases
Plus strand

Genomic View for ZNF253 Gene

Genes around ZNF253 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF253 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF253 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF253 Gene

Proteins for ZNF253 Gene

  • Protein details for ZNF253 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 253
    Protein Accession:
    Secondary Accessions:
    • A4FVA7
    • Q0P6G3
    • Q6P0L2
    • Q8NCA3
    • Q8NCF9

    Protein attributes for ZNF253 Gene

    499 amino acids
    Molecular mass:
    57602 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH14148.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11257.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF253 Gene


neXtProt entry for ZNF253 Gene

Proteomics data for ZNF253 Gene at MOPED

Post-translational modifications for ZNF253 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF253 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF253 Gene

Domains & Families for ZNF253 Gene

Gene Families for ZNF253 Gene

Protein Domains for ZNF253 Gene

Suggested Antigen Peptide Sequences for ZNF253 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 11 C2H2-type zinc fingers.
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 11 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF253: view

Function for ZNF253 Gene

Molecular function for ZNF253 Gene

UniProtKB/Swiss-Prot Function:
May function as a transcription factor. Seem to have a transcriptional repression activity.
genes like me logo Genes that share phenotypes with ZNF253: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF253 Gene

Localization for ZNF253 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF253 Gene

Subcellular locations from

Jensen Localization Image for ZNF253 Gene COMPARTMENTS Subcellular localization image for ZNF253 gene
Compartment Confidence
nucleus 3

No data available for Gene Ontology (GO) - Cellular Components for ZNF253 Gene

Pathways & Interactions for ZNF253 Gene

SuperPathways for ZNF253 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF253: view

Pathways by source for ZNF253 Gene

2 Reactome pathways for ZNF253 Gene

Gene Ontology (GO) - Biological Process for ZNF253 Gene


No data available for SIGNOR curated interactions for ZNF253 Gene

Drugs & Compounds for ZNF253 Gene

No Compound Related Data Available

Transcripts for ZNF253 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF253 Gene

No ASD Table

Relevant External Links for ZNF253 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF253 Gene

mRNA expression in normal human tissues for ZNF253 Gene

mRNA Expression by UniProt/SwissProt for ZNF253 Gene

Tissue specificity: Expressed in bone marrow and in monocytic and immature erythroid cell lines.
genes like me logo Genes that share expression patterns with ZNF253: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for ZNF253 Gene

Orthologs for ZNF253 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF253 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Zfp65 35
  • 67.43 (n)
  • 57.65 (a)
Zfp65 16
Zfp386 36
  • 33 (a)
(Pan troglodytes)
Mammalia ZNF253 35
  • 99.1 (n)
  • 98.65 (a)
ZNF253 36
  • 99 (a)
(Bos Taurus)
Mammalia -- 36
  • 49 (a)
(Canis familiaris)
Mammalia -- 36
  • 34 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 34 (a)
-- 36
  • 49 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 48 (a)
-- 36
  • 31 (a)
-- 36
  • 38 (a)
-- 36
  • 35 (a)
-- 36
  • 28 (a)
-- 36
  • 29 (a)
-- 36
  • 28 (a)
-- 36
  • 27 (a)
Species with no ortholog for ZNF253:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF253 Gene

Gene Tree for ZNF253 (if available)
Gene Tree for ZNF253 (if available)

Paralogs for ZNF253 Gene

(541) SIMAP similar genes for ZNF253 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF253: view

Variants for ZNF253 Gene

Sequence variations from dbSNP and Humsavar for ZNF253 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs7256317 -- 19,884,178(+) AAGAT(G/T)GTTAT intron-variant
rs7408367 -- 19,885,398(+) tcttt(C/T)tttct intron-variant
rs8104555 -- 19,888,033(+) tttcc(G/T)aaaga intron-variant
rs8105329 -- 19,882,903(+) GAAGC(A/G)GAGGT intron-variant
rs8105482 -- 19,883,064(+) TAGTT(A/G)TGGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF253 Gene

Variant ID Type Subtype PubMed ID
dgv3791n71 CNV Loss 21882294
nsv519535 CNV Gain 19592680
esv2718296 CNV Deletion 23290073
dgv550e201 CNV Deletion 23290073
dgv3792n71 CNV Gain 21882294
esv2718298 CNV Deletion 23290073
esv2259143 CNV Deletion 18987734
nsv138332 CNV Loss 16902084
esv2718299 CNV Deletion 23290073

Variation tolerance for ZNF253 Gene

Residual Variation Intolerance Score: 59.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.96; 19.85% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF253 Gene

Disorders for ZNF253 Gene

Relevant External Links for ZNF253

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF253 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF253 Gene

Publications for ZNF253 Gene

  1. Molecular cloning of six novel Kruppel-like zinc finger genes from hematopoietic cells and identification of a novel transregulatory domain KRNB. (PMID: 10585455) Han Z.-G. … Chen Z. (J. Biol. Chem. 1999) 2 3 4 67
  2. LDOC1, a novel MZF-1-interacting protein, induces apoptosis. (PMID: 15670815) Inoue M. … Ra C. (FEBS Lett. 2005) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for ZNF253 Gene

Sources for ZNF253 Gene