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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF251 Gene

protein-coding   GIFtS: 44
GCID: GC08M145946

Zinc Finger Protein 251

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 2511 2

External Ids:    HGNC: 130451   Entrez Gene: 909872   Ensembl: ENSG000001981697   UniProtKB: Q9BRH93   

Export aliases for ZNF251 gene to outside databases

Previous GC identifers: GC00U990512 GC08M145951 GC08M145561 GC08M145917 GC08M141061


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF251 Gene: 
ZNF251 (zinc finger protein 251) is a protein-coding gene. Diseases associated with ZNF251 include influenza. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF420.

UniProtKB/Swiss-Prot: ZN251_HUMAN, Q9BRH9
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_037704.5  NC_018919.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF251 gene promoter:
         Max1   RFX1   AP-2gamma   PPAR-gamma1   AP-2beta   PPAR-gamma2   AP-2alpha   c-Myc   AP-2alphaA   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ZNF251

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF251


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.3   Ensembl cytogenetic band:  8q24.3   HGNC cytogenetic band: 8q24.3

ZNF251 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF251 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M145946:  view genomic region     (about GC identifiers)

Start:
145,946,294 bp from pter      End:
145,981,802 bp from pter
Size:
35,509 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN251_HUMAN, Q9BRH9 (See protein sequence)
Recommended Name: Zinc finger protein 251  
Size: 671 amino acids; 75763 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: Q2M219

Explore the universe of human proteins at neXtProt for ZNF251: NX_Q9BRH9

Explore proteomics data for ZNF251 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BRH9

  • ZNF251 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF251 Protein Expression
    REFSEQ proteins: NP_612376.1  
    ENSEMBL proteins: 
     ENSP00000292562   ENSP00000431809  

    Human Recombinant Protein Products for ZNF251: 
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    Cloud-Clone Corp. Proteins for ZNF251 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF251 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9BRH9

    ProtoNet protein and cluster: Q9BRH9

    UniProtKB/Swiss-Prot: ZN251_HUMAN, Q9BRH9
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 14 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF251 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN251_HUMAN, Q9BRH9
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF251 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF251

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    3 Interacting proteins for ZNF251 (Q9BRH92, 3 ENSP000002925624) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD1Q157972, 3MINT-62025 I2D: score=2 
    FEZ2Q9UHY83, ENSP000003685474I2D: score=1 STRING: ENSP00000368547
    FEZ1Q996893I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF251 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF251 (ZN251)

    Search CenterWatch for drugs/clinical trials and news about ZNF251 / ZN251

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF251 gene: 
    NM_138367.1  

    Unigene Cluster for ZNF251:

    Zinc finger protein 251
    Hs.534516  [show with all ESTs]
    Unigene Representative Sequence: NM_138367
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000524394 ENST00000292562(uc003zdv.4) ENST00000525191 ENST00000530353

    miRNA
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    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ZNF251
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    Additional mRNA sequence: 

    AK000435.1 AK027286.1 AK091638.1 BC006258.2 BC093984.1 BC112137.1 

    8 DOTS entries:

    DT.213258  DT.97772485  DT.70104321  DT.91819481  DT.91952198  DT.121469545  DT.121469553  DT.40111704 

    24/70 AceView cDNA sequences (see all 70):

    BE502940 BU674002 CA395360 BI871126 AA962296 AA372063 BU752943 AK027286 
    BX103704 BC006258 CK820133 AW102867 BM354221 BQ024815 BM273226 AA431494 
    CK820132 BX419253 BF530002 AK000435 AI052616 BG716982 CK003146 BX952650 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF251    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7
    SP1:              -     -                                   -     -         
    SP2:              -     -                                                   
    SP3:                                                                        
    SP4:                                                        -               
    SP5:                                                                        


    ECgene alternative splicing isoforms for ZNF251

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF251 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACGAATGGAT
    ZNF251 Expression
    About this image


    See ZNF251 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF251

    SOURCE GeneReport for Unigene cluster: Hs.534516
        SABiosciences Custom PCR Arrays for ZNF251
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF251 gene from 3/5 species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp2511 , 5 zinc finger protein 2511, 5 77.17(n)1
    74.88(a)1
      15 (36.28 cM)5
    715911  NM_001007568.21  NP_001007569.11 
     768521485 
    chicken
    (Gallus gallus)
    Aves --
    ZNF2506
    (see all 12)
    zinc finger protein 250
    (see all 12)
    47(a)
    40(a)
    (see all 12)
    many ↔ many
    many ↔ many
    (see all 12)
    JH375242.1(146619-147632)
    18(30334-33130)
    zebrafish
    (Danio rerio)
    Actinopterygii ZNF3246
    zinc finger protein 324
    44(a)
    1 → many
    4(57308896-57321801)


    ENSEMBL Gene Tree for ZNF251 (if available)
    TreeFam Gene Tree for ZNF251 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF251 gene
    ZNF4202  ZNF780A2  ZNF6652  ZNF724P2  ZNF72  ZNF232  ZNF4322  ZNF33A2  
    ZNF2342  ZNF302  ZNF5732  ZNF4292  ZNF5402  ZNF6052  ZNF842  ZNF1892  
    ZNF5712  ZNF6302  ZNF932  ZNF162  ZNF2832  ZNF3472  ZNF4842  ZNF1352  
    ZNF1842  ZNF585B2  ZNF412  ZNF6152  ZNF5692  ZNF4702  
    18/512 SIMAP similar genes for ZNF251 using alignment to 3 protein entries:     ZN251_HUMAN (see all proteins) (see all similar genes):
    ZNF78L1    HZF36    ZNF300P1    ZNF    DKFZp313M0722    ZNF232
    ZNF323    ZSCAN31    kr-znf3    HZF30    ZNF852    DKFZp666C237
    DKFZp686M04222    DKFZp762K012    ZNF660    ZSCAN22    zf30    POM121C

    ZNF251 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ZNF251
    PGOHUM00000238014


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/907 SNPs in ZNF251 are shown (see all 907)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1153924061,2
    C,F--145945945(+) CCATAC/TTGAAA 1 -- int11Minor allele frequency- T:0.23WA 118
    rs70040291,2
    C,F,A,H--145946037(+) cactcT/Cacaca 1 -- int119Minor allele frequency- C:0.32NS EA NA WA 2346
    rs1932283931,2
    --145946043(+) ACACAG/TGCAAT 1 -- int10--------
    rs1851926441,2
    --145946090(+) GCCACA/GTGCAA 1 -- int10--------
    rs1441722611,2
    --145946097(+) GCAAAC/TAGCTG 1 -- int10--------
    rs1900885141,2
    --145946113(+) TATTTC/TTGGAA 1 -- int10--------
    rs1816991951,2
    --145946185(+) GGAGGA/GGTTAA 1 -- int10--------
    rs1176101661,2
    F--145946209(+) CAAAGG/CAATTC 1 -- int11Minor allele frequency- C:0.03NA 120
    rs119904791,2
    C,F,H--145946226(+) gtggtG/Aaagat 1 -- int17Minor allele frequency- A:0.03NS EA NA CSA WA 544
    rs45171651,2
    H--145946267(+) ATTGTA/CTGTTT 1 -- int14Minor allele frequency- C:0.00NS EA 416

    HapMap Linkage Disequilibrium report for ZNF251 (145946294 - 145981802 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for ZNF251:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv522459CNV Loss19592680
    nsv891897CNV Loss21882294
    dgv7985n71CNV Loss21882294
    nsv891925CNV Loss21882294
    nsv891807CNV Loss21882294
    nsv428208CNV Gain18775914
    nsv891926CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for ZNF251:    About MalaCards
    influenza    


    ZNF251 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZNF251
    Human Genome Epidemiology (HuGE) Navigator: ZNF251 (1 document)

    Export disorders for ZNF251 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF251 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with ZNF251)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    5. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    7. DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (2006)
    8. FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region. (PubMed id 16484223)1 Assmann E.M.... Kobarg J. (2006)
    9. Functional proteomics mapping of a human signaling pathway. (PubMed id 15231748)1 Colland F....Gauthier J.M. (2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 90987 HGNC: 13045 AceView: ZNF251 Ensembl:ENSG00000198169 euGenes: HUgn90987
    ECgene: ZNF251 H-InvDB: ZNF251

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF251 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF251 gene:
    Search GeneIP for patents involving ZNF251

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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