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Aliases for ZNF251 Gene

Aliases for ZNF251 Gene

  • Zinc Finger Protein 251 2 3 5

External Ids for ZNF251 Gene

Previous GeneCards Identifiers for ZNF251 Gene

  • GC00U990512
  • GC08M145951
  • GC08M145561
  • GC08M145917
  • GC08M141061
  • GC08M145946

Summaries for ZNF251 Gene

GeneCards Summary for ZNF251 Gene

ZNF251 (Zinc Finger Protein 251) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF7.

UniProtKB/Swiss-Prot for ZNF251 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF251 Gene

Genomics for ZNF251 Gene

Regulatory Elements for ZNF251 Gene

Enhancers for ZNF251 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G144455 1.4 Ensembl ENCODE 128.2 +300.0 299971 1.6 HNRNPUL1 HDGF PKNOX1 FOXA2 CREB3L1 ARNT AGO1 ZFP64 SIN3A ZNF2 ZNF251 ZNF623 ZNF250 ZNF34 LRRC14 ZNF517 GPAA1 VPS28 TMED10P1 ENSG00000255164
GH08G143914 2.2 FANTOM5 Ensembl ENCODE dbSUPER 28.2 +819.3 819287 45.2 CREB3L1 MLX AGO1 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 PLEC ZNF251 ZNF517 ZNF250 LOC105375803 LRRC14 ZNF696 ZNF34 ZNF623 CYHR1
GH08G144407 1.4 ENCODE dbSUPER 28.2 +346.2 346248 4.8 HDGF HNRNPUL1 FOXA2 CREB3L1 ARNT AGO1 ZFP64 ARID4B SIN3A DMAP1 ZNF251 CPSF1 ZNF517 ZNF250 LOC105375803 LRRC14 TMED10P1 ENSG00000255164 ZNF34 ZNF623
GH08G144101 1.2 ENCODE 31.4 +652.5 652506 4.0 CREB3L1 AGO1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 SP3 NFYC ZFP41 ZNF623 ZNF250 ZNF251 ZNF517 WDR97 ENSG00000255224 ZNF34 LRRC14 ZNF696 ENSG00000255164
GH08G144506 1.4 ENCODE dbSUPER 26.1 +247.4 247448 4.0 HNRNPUL1 HDGF PKNOX1 ARNT CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZNF2 ZNF251 LRRC14 ZNF250 VPS28 PPP1R16A ZNF623 LOC105375803 ENSG00000254533 ZNF517 TMED10P1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF251 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF251 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000232285 917 1401 HNRNPUL1 PKNOX1 MLX CREB3L1 ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF207

Genomic Location for ZNF251 Gene

Chromosome:
8
Start:
144,720,907 bp from pter
End:
144,756,417 bp from pter
Size:
35,511 bases
Orientation:
Minus strand

Genomic View for ZNF251 Gene

Genes around ZNF251 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF251 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF251 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF251 Gene

Proteins for ZNF251 Gene

  • Protein details for ZNF251 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRH9-ZN251_HUMAN
    Recommended name:
    Zinc finger protein 251
    Protein Accession:
    Q9BRH9
    Secondary Accessions:
    • Q2M219

    Protein attributes for ZNF251 Gene

    Size:
    671 amino acids
    Molecular mass:
    75763 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF251 Gene

Post-translational modifications for ZNF251 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF251 Gene

No data available for DME Specific Peptides for ZNF251 Gene

Domains & Families for ZNF251 Gene

Gene Families for ZNF251 Gene

Protein Domains for ZNF251 Gene

Suggested Antigen Peptide Sequences for ZNF251 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BRH9

UniProtKB/Swiss-Prot:

ZN251_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF251: view

Function for ZNF251 Gene

Molecular function for ZNF251 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF251 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF251: view
genes like me logo Genes that share phenotypes with ZNF251: view

Animal Model Products

CRISPR Products

miRNA for ZNF251 Gene

miRTarBase miRNAs that target ZNF251

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF251 Gene

Localization for ZNF251 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF251 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF251 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF251 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF251: view

Pathways & Interactions for ZNF251 Gene

SuperPathways for ZNF251 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF251 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,IBA --
genes like me logo Genes that share ontologies with ZNF251: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF251 Gene

Drugs & Compounds for ZNF251 Gene

No Compound Related Data Available

Transcripts for ZNF251 Gene

Unigene Clusters for ZNF251 Gene

Zinc finger protein 251:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF251 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7
SP1: - - - -
SP2: - -
SP3:
SP4: -
SP5:

Relevant External Links for ZNF251 Gene

GeneLoc Exon Structure for
ZNF251
ECgene alternative splicing isoforms for
ZNF251

Expression for ZNF251 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF251 Gene

Protein differential expression in normal tissues from HIPED for ZNF251 Gene

This gene is overexpressed in Urine (35.6) and Adrenal (30.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF251 Gene



Protein tissue co-expression partners for ZNF251 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF251 Gene:

ZNF251

SOURCE GeneReport for Unigene cluster for ZNF251 Gene:

Hs.534516

Evidence on tissue expression from TISSUES for ZNF251 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with ZNF251: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF251 Gene

Orthologs for ZNF251 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF251 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF251 34 35
  • 99.21 (n)
rat
(Rattus norvegicus)
Mammalia Zfp251 34
  • 77.71 (n)
mouse
(Mus musculus)
Mammalia Zfp251 34 16 35
  • 76.85 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 47 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 31 (a)
ManyToMany
Species where no ortholog for ZNF251 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF251 Gene

ENSEMBL:
Gene Tree for ZNF251 (if available)
TreeFam:
Gene Tree for ZNF251 (if available)

Paralogs for ZNF251 Gene

Paralogs for ZNF251 Gene

(512) SIMAP similar genes for ZNF251 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for ZNF251 Gene

genes like me logo Genes that share paralogs with ZNF251: view

Variants for ZNF251 Gene

Sequence variations from dbSNP and Humsavar for ZNF251 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000093074 -- 144,744,017(+) TTTTT(A/T)TTTTT intron-variant
rs1000254132 -- 144,755,702(+) GGGAG(A/T)GCCCA intron-variant, upstream-variant-2KB
rs1000431339 -- 144,750,185(+) CTCTT(C/T)AAACT intron-variant
rs1000488759 -- 144,752,428(+) GCATG(C/T)CCAAA intron-variant
rs1000520994 -- 144,744,513(+) CACAT(C/G)TTGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF251 Gene

Variant ID Type Subtype PubMed ID
esv3619140 CNV gain 21293372
nsv428208 CNV gain 18775914
nsv522459 CNV loss 19592680

Variation tolerance for ZNF251 Gene

Residual Variation Intolerance Score: 11.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.93; 35.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF251 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF251

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF251 Gene

Disorders for ZNF251 Gene

Relevant External Links for ZNF251

Genetic Association Database (GAD)
ZNF251
Human Genome Epidemiology (HuGE) Navigator
ZNF251
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF251

No disorders were found for ZNF251 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF251 Gene

Publications for ZNF251 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Yeast two-hybrid screening identified WDR77 as a novel interacting partner of TSC22D2. (PMID: 27337956) Li Q. … Xiong W. (Tumour Biol. 2016) 3 64
  5. MxA interacts with and is modified by the SUMOylation machinery. (PMID: 25447205) Brantis-de-Carvalho C.E. … Valentini S.R. (Exp. Cell Res. 2015) 3 64

Products for ZNF251 Gene

Sources for ZNF251 Gene

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