ZNF251 Gene
protein-coding GIFtS: 44
GCID: GC08M145946
|
|
zinc finger protein 251
| |
Aliases
for ZNF251 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 2511 2 |
Export aliases for ZNF251 gene to outside databasesPrevious GC identifers: GC00U990512 GC08M145951 GC08M145561 GC08M145917 GC08M141061 |
Summaries
for ZNF251 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN251_HUMAN, Q9BRH9Function: May be involved in transcriptional regulation
|
Genomic Views
for ZNF251 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_037704.5
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF251 gene promoter:
Max1 RFX1 AP-2gamma PPAR-gamma1 AP-2beta PPAR-gamma2 AP-2alpha c-Myc AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF251
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF251 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q24.3 Ensembl cytogenetic band: 8q24.3 HGNC cytogenetic band: 8q24.3ZNF251 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M145946: view genomic region
(about GC identifiers)
Start:
|
145,946,294 bp from pter |
End:
|
145,981,802 bp from pter |
Size:
|
35,509 bases |
Orientation:
|
minus strand |
|
Proteins
for ZNF251 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN251_HUMAN, Q9BRH9 (See
protein sequence)Recommended Name: Zinc finger protein 251 Size: 671 amino acids; 75763 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: Q2M219Explore the universe of human proteins at neXtProt for ZNF251: NX_Q9BRH9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BRH9
ZNF251 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_612376.1
ENSEMBL proteins: ENSP00000292562 ENSP00000431809
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
ZNF251 for ontologies About GeneDecksing
ZNF251 Antibody Products:
Assay Products for ZNF251: |
Protein
Domains /
Families
for ZNF251 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF251 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9BRH9ProtoNet protein and cluster: Q9BRH9 UniProtKB/Swiss-Prot: ZN251_HUMAN, Q9BRH9Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 14 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF251 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZN251_HUMAN, Q9BRH9Function: May be involved in transcriptional regulation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF251 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF251
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZNF251 (NM_138367) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF251 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ZNF251 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF251 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
ZNF251 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZNF251 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF251
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
3 Interacting proteins for ZNF251 (Q9BRH92, 3 ENSP000002925624) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF251 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF251 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF251
Search CenterWatch for drugs/clinical trials and news about ZNF251 / ZN251
|
Transcripts
for ZNF251 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF251 gene: NM_138367.1 Unigene Cluster for ZNF251: Zinc finger protein 251 Hs.534516 [show with all ESTs]Unigene Representative Sequence: NM_1383675 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000524394 ENST00000292562(uc003zdv.4) ENST00000533117 ENST00000525191
ENST00000530353
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF251 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF251
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF251 (NM_138367) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF251 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ZNF251 |
Additional cDNA sequence: AK000435.1 AK027286.1 AK091638.1 BC006258.2 BC093984.1 BC112137.1 8 DOTS entries: DT.213258 DT.97772485 DT.70104321 DT.91819481 DT.91952198 DT.121469545 DT.121469553 DT.40111704 24/70 AceView cDNA sequences (see all 70): BC006258 AW102867 AA962296 CA395360 BE502940 BQ024815 AK027286 BI871126 AA431494 BX103704 BM354221 BM273226 BU752943 CK820133 CK820132 AA372063 BU674002 AK000435 BX952650 AI745441 BG034084 CK003146 BF683734 BE741684
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF251 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6 | ^ | 7 |
|---|
|
| SP1: | | | | | - | | - | | | | | | | | | | | | - | | - | | | | |
| SP2: | | | | | - | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | - | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZNF251
|
Expression
for ZNF251 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF251 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACGAATGGAT
About this image
See ZNF251 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF251
SOURCE GeneReport for Unigene cluster: Hs.534516
SABiosciences Custom PCR Arrays for ZNF251
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF251
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNF251 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF251 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF251 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF251 |
Orthologs
for ZNF251 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZNF251 gene from 1/4 species (see all 4) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
zebrafish
(Danio rerio) |
Actinopterygii |
CU457794.16 |
-- |
52(a) |
1 → many |
4(35160994-35161866) |
ENSEMBL Gene Tree for ZNF251 (if available)
TreeFam Gene Tree for ZNF251 (if available) |
Paralogs
for ZNF251 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF251 gene
- ZNF5172
18/506 SIMAP similar genes for ZNF251 using alignment to 3 protein entries: ZN251_HUMAN (see all proteins)
(see all similar genes):ZNF78L1 ZNF66 HZF36 ZNF300P1 ZNF DKFZp313M0722
ZNF232 ZNF323 kr-znf3 HZF30 DKFZp666C237 DKFZp686M04222
DKFZp762K012 ZNF660 ZSCAN22 zf30 POM121C ZNF146
ZNF251 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ZNF251
PGOHUM00000238014
|
Genomic Variants
for ZNF251 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF251 (145946294 - 145981802 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF251: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF251 |
|
Disorders
/ Diseases
for ZNF251 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF251 for disorders About GeneDecksing
1  disease for ZNF251: About MalaCardsinfluenza
Human Genome Epidemiology (HuGE) Navigator: ZNF251 (1 document)
Export disorders for ZNF251 gene to outside databases
|
Publications
for ZNF251 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF251 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with ZNF251) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (2006)
- FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region. (PubMed id 16484223)1 Assmann E.M.... Kobarg J. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
|
External Searches for ZNF251 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF251 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF251 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF251 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF251 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF251 gene:
Search GeneIP for patents involving ZNF251
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF251 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF251 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF251 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF251 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for ZNF251 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF251 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF251 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF251 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF251 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF251 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF251 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF251 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF251 |
| |
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| |  |  |  |  | | | | |
 |
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 | | | ZNF251 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF251 |
|  |  |  | | | | Search ThermoFisher Antibodies for ZNF251 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ZNF251 |
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