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ZNF251 Gene

protein-coding   GIFtS: 46
GCID: GC08M145946

Zinc Finger Protein 251

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Zinc Finger Protein 2511 2

External Ids:    HGNC: 130451   Entrez Gene: 909872   Ensembl: ENSG000001981697   UniProtKB: Q9BRH93   
ORGUL members:         

Export aliases for ZNF251 gene to outside databases

Previous GC identifers: GC00U990512 GC08M145951 GC08M145561 GC08M145917 GC08M141061


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF251 Gene:
ZNF251 (zinc finger protein 251) is a protein-coding gene. An important paralog of this gene is ZNF334.

UniProtKB/Swiss-Prot: ZN251_HUMAN, Q9BRH9
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NT_008046.17  NT_187569.1  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF251 gene promoter:
         Max1   RFX1   AP-2gamma   PPAR-gamma1   AP-2beta   PPAR-gamma2   AP-2alpha   c-Myc   AP-2alphaA   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ZNF251

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF251


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.3   Ensembl cytogenetic band:  8q24.3   HGNC cytogenetic band: 8q24.3

ZNF251 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF251 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M145946:  view genomic region     (about GC identifiers)

Start:
145,946,294 bp from pter      End:
145,981,802 bp from pter
Size:
35,509 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZN251_HUMAN, Q9BRH9 (See protein sequence)
Recommended Name: Zinc finger protein 251  
Size: 671 amino acids; 75763 Da
Secondary accessions: Q2M219

Explore the universe of human proteins at neXtProt for ZNF251: NX_Q9BRH9

Explore proteomics data for ZNF251 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF251 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_612376.1  
    ENSEMBL proteins: 
     ENSP00000292562   ENSP00000431809  

    ZNF251 Human Recombinant Protein Products:

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    antibodies-online antibodies for ZNF251 (15 products) 

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    antibodies-online kits for ZNF251 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9BRH9

    ProtoNet protein and cluster: Q9BRH9

    UniProtKB/Swiss-Prot: ZN251_HUMAN, Q9BRH9
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 14 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    Find genes that share domains with ZNF251           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN251_HUMAN, Q9BRH9
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IBA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF251           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ZNF251

    miRNA
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    miRTarBase miRNAs that target ZNF251:
    hsa-mir-335-5p (MIRT017209)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN251_HUMAN, Q9BRH9: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZNF251           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF251
    Interactions:

        Search GeneGlobe Interaction Network for ZNF251

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    3 Interacting proteins for ZNF251 (Q9BRH92, 3 ENSP000002925624) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD1Q157972, 3MINT-62025 I2D: score=2 
    FEZ2Q9UHY83, ENSP000003685474I2D: score=1 STRING: ENSP00000368547
    FEZ1Q996893I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IBA--

    Find genes that share ontologies with ZNF251           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF251 (ZN251)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF251 gene: 
    NM_138367.1  

    Unigene Cluster for ZNF251:

    Zinc finger protein 251
    Hs.534516  [show with all ESTs]
    Unigene Representative Sequence: NM_138367
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000524394 ENST00000292562(uc003zdv.4) ENST00000525191 ENST00000530353

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      QuantiFast Probe-based Assays in human, mouse, rat ZNF251

    Additional mRNA sequence: 

    AK000435.1 AK027286.1 AK091638.1 BC006258.2 BC093984.1 BC112137.1 

    8 DOTS entries:

    DT.213258  DT.97772485  DT.70104321  DT.91819481  DT.91952198  DT.121469545  DT.121469553  DT.40111704 

    Selected AceView cDNA sequences (see all 70):

    AA962296 AA431494 BQ024815 BC006258 BX103704 BE502940 BM273226 CK820132 
    AK027286 BM354221 BI871126 BU674002 CA395360 AA372063 AW102867 BU752943 
    CK820133 BG716982 AA043771 BF683734 BX952650 CK001849 AK091638 CK003146 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF251    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7
    SP1:              -     -                                   -     -         
    SP2:              -     -                                                   
    SP3:                                                                        
    SP4:                                                        -               
    SP5:                                                                        


    ECgene alternative splicing isoforms for ZNF251

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF251 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACGAATGGAT
    ZNF251 Expression
    About this image

    ZNF251 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF251 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.534516
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for ZNF251 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp2511 , 5 zinc finger protein 2511, 5 76.85(n)1
    74.37(a)1
      15 (36.28 cM)5
    715911  NM_001007568.21  NP_001007569.11 
     768521485 


    ENSEMBL Gene Tree for ZNF251 (if available)
    TreeFam Gene Tree for ZNF251 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF251 gene
    ZNF3342  ZNF4202  ZNF780A2  ZNF6652  ZNF72  ZNF232  ZNF33A2  RBAK2  
    ZNF7172  ZNF302  ZNF5732  ZNF33B2  ZNF5402  ZNF6052  ZNF842  ZNF1892  
    ZNF5712  ZNF6302  ZNF3372  ZNF2832  ZNF4042  ZNF1352  ZNF4842  ZNF122  
    ZNF3452  ZNF1842  ZNF6992  ZNF412  ZNF6152  ZNF4702  ZNF5692  
    Selected SIMAP similar genes for ZNF251 using alignment to 3 protein entries:     ZN251_HUMAN (see all proteins) (see all similar genes):
    ZNF78L1    HZF36    ZNF300P1    ZNF    DKFZp313M0722    ZNF232
    ZNF323    ZSCAN31    kr-znf3    HZF30    ZNF852    DKFZp666C237
    DKFZp686M04222    DKFZp762K012    ZNF660    ZSCAN22    zf30    POM121C

    Find genes that share paralogs with ZNF251           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ZNF251
    PGOHUM00000238014


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF251 (see all 907)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1153924061,2
    C,F--145945945(+) CCATAC/TTGAAA 1 -- int11Minor allele frequency- T:0.23WA 118
    rs70040291,2
    C,F,A,H--145946037(+) cactcT/Cacaca 1 -- int119Minor allele frequency- C:0.32NS EA NA WA 2346
    rs1932283931,2
    --145946043(+) ACACAG/TGCAAT 1 -- int10--------
    rs1851926441,2
    --145946090(+) GCCACA/GTGCAA 1 -- int10--------
    rs1441722611,2
    --145946097(+) GCAAAC/TAGCTG 1 -- int10--------
    rs1900885141,2
    --145946113(+) TATTTC/TTGGAA 1 -- int10--------
    rs1816991951,2
    --145946185(+) GGAGGA/GGTTAA 1 -- int10--------
    rs1176101661,2
    F--145946209(+) CAAAGG/CAATTC 1 -- int11Minor allele frequency- C:0.03NA 120
    rs119904791,2
    C,F,H--145946226(+) gtggtG/Aaagat 1 -- int17Minor allele frequency- A:0.03NS EA NA CSA WA 544
    rs45171651,2
    H--145946267(+) ATTGTA/CTGTTT 1 -- int14Minor allele frequency- C:0.00NS EA 416

    HapMap Linkage Disequilibrium report for ZNF251 (145946294 - 145981802 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for ZNF251:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv522459CNV Loss19592680
    nsv891897CNV Loss21882294
    dgv7985n71CNV Loss21882294
    nsv891925CNV Loss21882294
    nsv891807CNV Loss21882294
    nsv428208CNV Gain18775914
    nsv891926CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with ZNF251           About GenesLikeMe

    Genetic Association Database (GAD): ZNF251
    Human Genome Epidemiology (HuGE) Navigator: ZNF251 (1 document)

    Export disorders for ZNF251 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF251 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with ZNF251)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    5. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    6. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    8. DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (Nature 2006)
    9. FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region. (PubMed id 16484223)1 Assmann E.M.... Kobarg J. (J. Biol. Chem. 2006)
    10. Functional proteomics mapping of a human signaling pathway. (PubMed id 15231748)1 Colland F....Gauthier J.M. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 90987 HGNC: 13045 AceView: ZNF251 Ensembl:ENSG00000198169 euGenes: HUgn90987
    ECgene: ZNF251 H-InvDB: ZNF251

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF251 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF251 gene:
    Search GeneIP for patents involving ZNF251

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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