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Aliases for ZNF251 Gene

Aliases for ZNF251 Gene

  • Zinc Finger Protein 251 2 3 5

External Ids for ZNF251 Gene

Previous GeneCards Identifiers for ZNF251 Gene

  • GC00U990512
  • GC08M145951
  • GC08M145561
  • GC08M145917
  • GC08M141061
  • GC08M145946

Summaries for ZNF251 Gene

GeneCards Summary for ZNF251 Gene

ZNF251 (Zinc Finger Protein 251) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF34.

UniProtKB/Swiss-Prot for ZNF251 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF251 Gene

Genomics for ZNF251 Gene

Regulatory Elements for ZNF251 Gene

Enhancers for ZNF251 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF251 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF251 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF251 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF251 Gene

Chromosome:
8
Start:
144,720,907 bp from pter
End:
144,756,417 bp from pter
Size:
35,511 bases
Orientation:
Minus strand

Genomic View for ZNF251 Gene

Genes around ZNF251 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF251 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF251 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF251 Gene

Proteins for ZNF251 Gene

  • Protein details for ZNF251 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRH9-ZN251_HUMAN
    Recommended name:
    Zinc finger protein 251
    Protein Accession:
    Q9BRH9
    Secondary Accessions:
    • Q2M219

    Protein attributes for ZNF251 Gene

    Size:
    671 amino acids
    Molecular mass:
    75763 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF251 Gene

Proteomics data for ZNF251 Gene at MOPED

Post-translational modifications for ZNF251 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF251 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF251 Gene

Domains & Families for ZNF251 Gene

Gene Families for ZNF251 Gene

Protein Domains for ZNF251 Gene

Suggested Antigen Peptide Sequences for ZNF251 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BRH9

UniProtKB/Swiss-Prot:

ZN251_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 14 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 14 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF251: view

Function for ZNF251 Gene

Molecular function for ZNF251 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF251: view

Animal Model Products

CRISPR Products

miRNA for ZNF251 Gene

miRTarBase miRNAs that target ZNF251

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF251 Gene

Localization for ZNF251 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF251 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF251 Gene COMPARTMENTS Subcellular localization image for ZNF251 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF251 Gene

Pathways & Interactions for ZNF251 Gene

SuperPathways for ZNF251 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF251 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZNF251 Gene

Drugs & Compounds for ZNF251 Gene

No Compound Related Data Available

Transcripts for ZNF251 Gene

Unigene Clusters for ZNF251 Gene

Zinc finger protein 251:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF251 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7
SP1: - - - -
SP2: - -
SP3:
SP4: -
SP5:

Relevant External Links for ZNF251 Gene

GeneLoc Exon Structure for
ZNF251
ECgene alternative splicing isoforms for
ZNF251

Expression for ZNF251 Gene

mRNA expression in normal human tissues for ZNF251 Gene

Protein differential expression in normal tissues from HIPED for ZNF251 Gene

This gene is overexpressed in Urine (35.6) and Adrenal (30.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF251 Gene



SOURCE GeneReport for Unigene cluster for ZNF251 Gene Hs.534516

genes like me logo Genes that share expression patterns with ZNF251: view

Protein tissue co-expression partners for ZNF251 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF251 Gene

Orthologs for ZNF251 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF251 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Zfp251 35
  • 76.85 (n)
  • 74.37 (a)
Zfp251 16
Zfp251 36
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZNF251 35
  • 99.21 (n)
  • 98.81 (a)
ZNF251 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp251 35
  • 77.71 (n)
  • 75.24 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 47 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 31 (a)
ManyToMany
Species with no ortholog for ZNF251:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF251 Gene

ENSEMBL:
Gene Tree for ZNF251 (if available)
TreeFam:
Gene Tree for ZNF251 (if available)

Paralogs for ZNF251 Gene

(512) SIMAP similar genes for ZNF251 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for ZNF251 Gene

genes like me logo Genes that share paralogs with ZNF251: view

Variants for ZNF251 Gene

Sequence variations from dbSNP and Humsavar for ZNF251 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs2258589 -- 144,721,402(-) ATCCG(C/G)ATACT utr-variant-3-prime
rs2466400 -- 144,723,970(+) CAGGC(A/G)CGGTG intron-variant
rs2466953 -- 144,750,918(+) aatct(C/T)ggctc intron-variant, downstream-variant-500B
rs2466954 -- 144,725,291(+) attac(A/G)ggcgt intron-variant
rs2466955 -- 144,728,922(+) tgtct(C/T)tacta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF251 Gene

Variant ID Type Subtype PubMed ID
nsv891807 CNV Loss 21882294
nsv428208 CNV Gain 18775914
nsv891897 CNV Loss 21882294
nsv522459 CNV Loss 19592680
nsv891925 CNV Loss 21882294
nsv891926 CNV Gain 21882294
dgv7985n71 CNV Loss 21882294

Variation tolerance for ZNF251 Gene

Residual Variation Intolerance Score: 11.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.93; 35.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF251 Gene

HapMap Linkage Disequilibrium report
ZNF251

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF251 Gene

Disorders for ZNF251 Gene

Relevant External Links for ZNF251

Genetic Association Database (GAD)
ZNF251
Human Genome Epidemiology (HuGE) Navigator
ZNF251
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF251

No disorders were found for ZNF251 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF251 Gene

Publications for ZNF251 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. MxA interacts with and is modified by the SUMOylation machinery. (PMID: 25447205) Brantis-de-Carvalho C.E. … Valentini S.R. (Exp. Cell Res. 2015) 3
  3. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PMID: 22990118) Woods N.T. … Monteiro A.N. (Sci Signal 2012) 3
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for ZNF251 Gene

Sources for ZNF251 Gene

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