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Aliases for ZNF250 Gene

Aliases for ZNF250 Gene

  • Zinc Finger Protein 250 2 3
  • Zinc Finger Protein 647 2 3 4
  • ZNF647 3 4
  • Zinc Finger Protein (Clone 647) 3
  • ZFP647 3

External Ids for ZNF250 Gene

Previous HGNC Symbols for ZNF250 Gene

  • ZNF647

Previous GeneCards Identifiers for ZNF250 Gene

  • GC00U990513
  • GC08M146078
  • GC08M141218

Summaries for ZNF250 Gene

GeneCards Summary for ZNF250 Gene

ZNF250 (Zinc Finger Protein 250) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF529.

UniProtKB/Swiss-Prot for ZNF250 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF250 Gene

Genomics for ZNF250 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF250 Gene

144,876,497 bp from pter
144,902,168 bp from pter
25,672 bases
Minus strand

Genomic View for ZNF250 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF250 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF250 Gene

No data available for Regulatory Elements for ZNF250 Gene

Proteins for ZNF250 Gene

  • Protein details for ZNF250 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 250
    Protein Accession:
    Secondary Accessions:
    • D3DWP1
    • Q59HE9
    • Q8N942
    • Q96AH9

    Protein attributes for ZNF250 Gene

    560 amino acids
    Molecular mass:
    63468 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAD92047.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAA34358.1; Type=Frameshift; Positions=458, 488; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF250 Gene


neXtProt entry for ZNF250 Gene

Proteomics data for ZNF250 Gene at MOPED

Post-translational modifications for ZNF250 Gene

  • Ubiquitination at Lys253
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF250 Gene

No data available for DME Specific Peptides for ZNF250 Gene

Domains for ZNF250 Gene

Gene Families for ZNF250 Gene

  • ZNF :Zinc fingers, C2H2-type

Suggested Antigen Peptide Sequences for ZNF250 Gene

Graphical View of Domain Structure for InterPro Entry



  • P15622
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 13 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF250: view

Function for ZNF250 Gene

Molecular function for ZNF250 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF250 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IBA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF250: view

Phenotypes for ZNF250 Gene

MGI mutant phenotypes for ZNF250:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with ZNF250: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF250 Gene

Localization for ZNF250 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF250 Gene

Subcellular locations from

Jensen Localization Image for ZNF250 Gene COMPARTMENTS Subcellular localization image for ZNF250 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF250 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF250: view

Pathways for ZNF250 Gene

SuperPathways for ZNF250 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF250: view

Pathways by source for ZNF250 Gene

2 Reactome pathways for ZNF250 Gene

Gene Ontology (GO) - Biological Process for ZNF250 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF250: view

Transcripts for ZNF250 Gene

Unigene Clusters for ZNF250 Gene

Zinc finger protein 250:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF250

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF250 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d ^ 9
SP1: -
SP2: - -
SP3: -
SP4: - - - - -
SP5: - -
SP6: - - - - -
SP7: - -

Relevant External Links for ZNF250 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF250 Gene

mRNA expression in normal human tissues for ZNF250 Gene

Protein differential expression in normal tissues for ZNF250 Gene

This gene is overexpressed in Fetal heart (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF250 Gene

SOURCE GeneReport for Unigene cluster for ZNF250 Gene Hs.532277

genes like me logo Genes that share expressions with ZNF250: view

Expression partners for ZNF250 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF250 Gene

Orthologs for ZNF250 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZNF250 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZNF250 35
  • 77.13 (n)
  • 78.04 (a)
(Canis familiaris)
Mammalia ZNF250 35
  • 77.51 (n)
  • 83.09 (a)
ZNF250 36
  • 77 (a)
(Mus musculus)
Mammalia Zfp647 35
  • 82.52 (n)
  • 86.33 (a)
Zfp647 16
Zfp647 36
  • 86 (a)
(Pan troglodytes)
Mammalia ZNF250 35
  • 99.82 (n)
  • 99.82 (a)
ZNF250 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Zfp647 35
  • 84.24 (n)
  • 87.62 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 37 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ADR1 38
Species with no ortholog for ZNF250:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF250 Gene

Gene Tree for ZNF250 (if available)
Gene Tree for ZNF250 (if available)

Paralogs for ZNF250 Gene

Selected SIMAP similar genes for ZNF250 Gene using alignment to 8 proteins: Pseudogenes for ZNF250 Gene

genes like me logo Genes that share paralogs with ZNF250: view

Variants for ZNF250 Gene

Sequence variations from dbSNP and Humsavar for ZNF250 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs391368 -- 144,901,392(-) TGAGT(G/T)GGGGG intron-variant, utr-variant-5-prime
rs391471 -- 144,888,975(-) ctggc(C/T)aacac intron-variant
rs393019 -- 144,888,502(-) cttac(A/C/G)cctca intron-variant
rs395369 -- 144,893,468(-) ctgta(A/G)tccca intron-variant
rs399490 -- 144,882,103(-) GAGAA(C/G)CCCTA missense, reference

Structural Variations from Database of Genomic Variants (DGV) for ZNF250 Gene

Variant ID Type Subtype PubMed ID
nsv469809 CNV Loss 16826518
nsv6450 CNV Insertion 18451855

Relevant External Links for ZNF250 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF250 Gene

Disorders for ZNF250 Gene

No disorders were found for ZNF250 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for ZNF250 Gene

Publications for ZNF250 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The ancient mammalian KRAB zinc finger gene cluster on human chromosome 8q24.3 illustrates principles of C2H2 zinc finger evolution associated with unique expression profiles in human tissues. (PMID: 20346131) Lorenz P. … Thiesen H.J. (BMC Genomics 2010) 2 3
  4. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PMID: 20360068) Hutchins J.R. … Peters J.M. (Science 2010) 3
  5. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 3

Products for ZNF250 Gene

Sources for ZNF250 Gene

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