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Aliases for ZNF250 Gene

Aliases for ZNF250 Gene

  • Zinc Finger Protein 250 2 3
  • Zinc Finger Protein 647 2 3 4
  • ZNF647 3 4
  • Zinc Finger Protein (Clone 647) 3
  • ZFP647 3

External Ids for ZNF250 Gene

Previous Symbols for ZNF250 Gene

  • ZNF647

Summaries for ZNF250 Gene

GeneCards Summary for ZNF250 Gene

ZNF250 (Zinc Finger Protein 250) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF529.

UniProtKB/Swiss-Prot for ZNF250 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF250 Gene

Genomics for ZNF250 Gene

Genomic Location for ZNF250 Gene

Start:
144,876,497 bp from pter
End:
144,902,168 bp from pter
Size:
25,672 bases
Orientation:
Minus strand

Genomic View for ZNF250 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF250 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF250 Gene

No data available for Regulatory Elements for ZNF250 Gene

Proteins for ZNF250 Gene

  • Protein details for ZNF250 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15622-ZN250_HUMAN
    Recommended name:
    Zinc finger protein 250
    Protein Accession:
    P15622
    Secondary Accessions:
    • D3DWP1
    • Q59HE9
    • Q8N942
    • Q96AH9

    Protein attributes for ZNF250 Gene

    Size:
    560 amino acids
    Molecular mass:
    63468 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAD92047.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAA34358.1; Type=Frameshift; Positions=458, 488; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF250 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF250 Gene

Proteomics data for ZNF250 Gene at MOPED

Post-translational modifications for ZNF250 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys253

Other Protein References for ZNF250 Gene

No data available for DME Specific Peptides for ZNF250 Gene

Domains for ZNF250 Gene

Gene Families for ZNF250 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

UniProtKB/Swiss-Prot:

ZN250_HUMAN
Domain:
  • Contains 1 KRAB domain.:
    • P15622
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.:
    • P15622
Similarity:
  • Contains 13 C2H2-type zinc fingers.:
    • P15622
genes like me logo Genes that share domains with ZNF250: view

Function for ZNF250 Gene

Molecular function for ZNF250 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF250 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IBA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF250: view

Phenotypes for ZNF250 Gene

MGI mutant phenotypes for ZNF250:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with ZNF250: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF250 Gene

Localization for ZNF250 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF250 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF250 Gene COMPARTMENTS Subcellular localization image for ZNF250 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF250 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF250: view

Pathways for ZNF250 Gene

SuperPathways for ZNF250 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF250: view

Pathways by source for ZNF250 Gene

2 Reactome pathways for ZNF250 Gene

Gene Ontology (GO) - Biological Process for ZNF250 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF250: view

Transcripts for ZNF250 Gene

Unigene Clusters for ZNF250 Gene

Zinc finger protein 250:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF250 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d ^ 9
SP1: -
SP2: - -
SP3: -
SP4: - - - - -
SP5: - -
SP6: - - - - -
SP7: - -

Relevant External Links for ZNF250 Gene

GeneLoc Exon Structure for
ZNF250
ECgene alternative splicing isoforms for
ZNF250

Expression for ZNF250 Gene

mRNA expression in normal human tissues for ZNF250 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF250 Gene

SOURCE GeneReport for Unigene cluster for ZNF250 Gene Hs.532277

genes like me logo Genes that share expressions with ZNF250: view

Orthologs for ZNF250 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZNF250 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF250 36
  • 99.82 (n)
  • 99.82 (a)
ZNF250 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF250 36
  • 77.13 (n)
  • 78.04 (a)
dog
(Canis familiaris)
Mammalia ZNF250 36
  • 77.51 (n)
  • 83.09 (a)
ZNF250 37
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp647 36
  • 82.52 (n)
  • 86.33 (a)
Zfp647 16
Zfp647 37
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 37 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Zfp647 36
  • 84.24 (n)
  • 87.62 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ADR1 39
Species with no ortholog for ZNF250:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF250 Gene

ENSEMBL:
Gene Tree for ZNF250 (if available)
TreeFam:
Gene Tree for ZNF250 (if available)

Paralogs for ZNF250 Gene

Selected SIMAP similar genes for ZNF250 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for ZNF250 Gene

genes like me logo Genes that share paralogs with ZNF250: view

Variants for ZNF250 Gene

Sequence variations from dbSNP and Humsavar for ZNF250 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs391368 -- 144,901,392(-) TGAGT(G/T)GGGGG intron-variant, utr-variant-5-prime
rs391471 -- 144,888,975(-) ctggc(C/T)aacac intron-variant
rs393019 -- 144,888,502(-) cttac(A/C/G)cctca intron-variant
rs395369 -- 144,893,468(-) ctgta(A/G)tccca intron-variant
rs399490 -- 144,882,103(-) GAGAA(C/G)CCCTA missense, reference

Structural Variations from Database of Genomic Variants (DGV) for ZNF250 Gene

Variant ID Type Subtype PubMed ID
nsv469809 CNV Loss 16826518
nsv6450 CNV Insertion 18451855

Relevant External Links for ZNF250 Gene

HapMap Linkage Disequilibrium report
ZNF250

Disorders for ZNF250 Gene

No disorders were found for ZNF250 Gene.

No data available for UniProtKB/Swiss-Prot for ZNF250 Gene

Publications for ZNF250 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The ancient mammalian KRAB zinc finger gene cluster on human chromosome 8q24.3 illustrates principles of C2H2 zinc finger evolution associated with unique expression profiles in human tissues. (PMID: 20346131) Lorenz P. … Thiesen H.J. (BMC Genomics 2010) 2 3
  4. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PMID: 20360068) Hutchins J.R. … Peters J.M. (Science 2010) 3
  5. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 3

Products for ZNF250 Gene

Sources for ZNF250 Gene

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