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Aliases for ZNF250 Gene

Aliases for ZNF250 Gene

  • Zinc Finger Protein 250 2 3 5
  • Zinc Finger Protein 647 2 3 4
  • ZNF647 3 4
  • Zinc Finger Protein (Clone 647) 3
  • ZFP647 3

External Ids for ZNF250 Gene

Previous HGNC Symbols for ZNF250 Gene

  • ZNF647

Previous GeneCards Identifiers for ZNF250 Gene

  • GC00U990513
  • GC08M146078
  • GC08M141218

Summaries for ZNF250 Gene

GeneCards Summary for ZNF250 Gene

ZNF250 (Zinc Finger Protein 250) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF34.

UniProtKB/Swiss-Prot for ZNF250 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF250 Gene

Genomics for ZNF250 Gene

Regulatory Elements for ZNF250 Gene

Promoters for ZNF250 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF250 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF250 Gene

Chromosome:
8
Start:
144,876,497 bp from pter
End:
144,902,305 bp from pter
Size:
25,809 bases
Orientation:
Minus strand

Genomic View for ZNF250 Gene

Genes around ZNF250 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF250 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF250 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF250 Gene

Proteins for ZNF250 Gene

  • Protein details for ZNF250 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15622-ZN250_HUMAN
    Recommended name:
    Zinc finger protein 250
    Protein Accession:
    P15622
    Secondary Accessions:
    • D3DWP1
    • Q59HE9
    • Q8N942
    • Q96AH9

    Protein attributes for ZNF250 Gene

    Size:
    560 amino acids
    Molecular mass:
    63468 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAD92047.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAA34358.1; Type=Frameshift; Positions=458, 488; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF250 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF250 Gene

Proteomics data for ZNF250 Gene at MOPED

Post-translational modifications for ZNF250 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF250 Gene

Domains & Families for ZNF250 Gene

Gene Families for ZNF250 Gene

Protein Domains for ZNF250 Gene

Suggested Antigen Peptide Sequences for ZNF250 Gene

Graphical View of Domain Structure for InterPro Entry

P15622

UniProtKB/Swiss-Prot:

ZN250_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 13 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 13 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF250: view

Function for ZNF250 Gene

Molecular function for ZNF250 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF250 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ZNF250: view
genes like me logo Genes that share phenotypes with ZNF250: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF250 Gene

Localization for ZNF250 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF250 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF250 Gene COMPARTMENTS Subcellular localization image for ZNF250 gene
Compartment Confidence
nucleus 5
cytosol 3

No data available for Gene Ontology (GO) - Cellular Components for ZNF250 Gene

Pathways & Interactions for ZNF250 Gene

SuperPathways for ZNF250 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF250: view

Pathways by source for ZNF250 Gene

2 Reactome pathways for ZNF250 Gene

Gene Ontology (GO) - Biological Process for ZNF250 Gene

None

No data available for SIGNOR curated interactions for ZNF250 Gene

Drugs & Compounds for ZNF250 Gene

No Compound Related Data Available

Transcripts for ZNF250 Gene

Unigene Clusters for ZNF250 Gene

Zinc finger protein 250:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF250 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d ^ 9
SP1: -
SP2: - -
SP3: -
SP4: - - - - -
SP5: - -
SP6: - - - - -
SP7: - -

Relevant External Links for ZNF250 Gene

GeneLoc Exon Structure for
ZNF250
ECgene alternative splicing isoforms for
ZNF250

Expression for ZNF250 Gene

mRNA expression in normal human tissues for ZNF250 Gene

Protein differential expression in normal tissues from HIPED for ZNF250 Gene

This gene is overexpressed in Fetal heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF250 Gene



SOURCE GeneReport for Unigene cluster for ZNF250 Gene Hs.532277

genes like me logo Genes that share expression patterns with ZNF250: view

Protein tissue co-expression partners for ZNF250 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF250 Gene

Orthologs for ZNF250 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZNF250 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF250 35
  • 77.13 (n)
  • 78.04 (a)
dog
(Canis familiaris)
Mammalia ZNF250 35
  • 77.51 (n)
  • 83.09 (a)
ZNF250 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp647 35
  • 82.52 (n)
  • 86.33 (a)
Zfp647 16
Zfp647 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZNF250 35
  • 99.82 (n)
  • 99.82 (a)
ZNF250 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp647 35
  • 84.24 (n)
  • 87.62 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 37 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ADR1 38
Species with no ortholog for ZNF250:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF250 Gene

ENSEMBL:
Gene Tree for ZNF250 (if available)
TreeFam:
Gene Tree for ZNF250 (if available)

Paralogs for ZNF250 Gene

(534) SIMAP similar genes for ZNF250 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for ZNF250 Gene

genes like me logo Genes that share paralogs with ZNF250: view

Variants for ZNF250 Gene

Sequence variations from dbSNP and Humsavar for ZNF250 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs439411 -- 144,893,491(+) atgcc(C/G)ggcta intron-variant
rs451467 -- 144,891,390(+) CAGAA(A/G)TCAAG intron-variant
rs452456 -- 144,893,460(-) ccagc(C/T)actca intron-variant
rs391368 -- 144,901,392(-) TGAGT(G/T)GGGGG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs391471 -- 144,888,975(-) ctggc(C/T)aacac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF250 Gene

Variant ID Type Subtype PubMed ID
nsv469809 CNV Loss 16826518
nsv6450 CNV Insertion 18451855

Variation tolerance for ZNF250 Gene

Residual Variation Intolerance Score: 23.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.70; 32.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF250 Gene

HapMap Linkage Disequilibrium report
ZNF250

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF250 Gene

Disorders for ZNF250 Gene

Relevant External Links for ZNF250

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF250

No disorders were found for ZNF250 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF250 Gene

Publications for ZNF250 Gene

  1. The ancient mammalian KRAB zinc finger gene cluster on human chromosome 8q24.3 illustrates principles of C2H2 zinc finger evolution associated with unique expression profiles in human tissues. (PMID: 20346131) Lorenz P. … Thiesen H.J. (BMC Genomics 2010) 2 3 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3
  5. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 3

Products for ZNF250 Gene

Sources for ZNF250 Gene

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