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Aliases for ZNF250 Gene

Aliases for ZNF250 Gene

  • Zinc Finger Protein 250 2 3 5
  • Zinc Finger Protein 647 2 3 4
  • ZNF647 3 4
  • Zinc Finger Protein (Clone 647) 3
  • ZFP647 3

External Ids for ZNF250 Gene

Previous HGNC Symbols for ZNF250 Gene

  • ZNF647

Previous GeneCards Identifiers for ZNF250 Gene

  • GC00U990513
  • GC08M146078
  • GC08M141218

Summaries for ZNF250 Gene

GeneCards Summary for ZNF250 Gene

ZNF250 (Zinc Finger Protein 250) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF135.

UniProtKB/Swiss-Prot for ZNF250 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF250 Gene

Genomics for ZNF250 Gene

Regulatory Elements for ZNF250 Gene

Enhancers for ZNF250 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G144455 1.4 Ensembl ENCODE 79.1 +445.9 445859 1.6 HNRNPUL1 HDGF PKNOX1 FOXA2 CREB3L1 ARNT AGO1 ZFP64 SIN3A ZNF2 ZNF251 ZNF623 ZNF250 ZNF34 LRRC14 ZNF517 GPAA1 VPS28 TMED10P1 ENSG00000255164
GH08G143914 2.2 FANTOM5 Ensembl ENCODE dbSUPER 23.7 +965.2 965175 45.2 CREB3L1 MLX AGO1 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 PLEC ZNF251 ZNF517 ZNF250 LOC105375803 LRRC14 ZNF696 ZNF34 ZNF623 CYHR1
GH08G144101 1.2 ENCODE 37.2 +798.4 798394 4.0 CREB3L1 AGO1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 SP3 NFYC ZFP41 ZNF623 ZNF250 ZNF251 ZNF517 WDR97 ENSG00000255224 ZNF34 LRRC14 ZNF696 ENSG00000255164
GH08G144407 1.4 ENCODE dbSUPER 23.7 +492.1 492136 4.8 HDGF HNRNPUL1 FOXA2 CREB3L1 ARNT AGO1 ZFP64 ARID4B SIN3A DMAP1 ZNF251 CPSF1 ZNF517 ZNF250 LOC105375803 LRRC14 TMED10P1 ENSG00000255164 ZNF34 ZNF623
GH08G144506 1.4 ENCODE dbSUPER 23.6 +393.3 393336 4.0 HNRNPUL1 HDGF PKNOX1 ARNT CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZNF2 ZNF251 LRRC14 ZNF250 VPS28 PPP1R16A ZNF623 LOC105375803 ENSG00000254533 ZNF517 TMED10P1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF250 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF250 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000232307 1105 2801 HDGF PKNOX1 FOXA2 MLX CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZNF2

Genomic Location for ZNF250 Gene

Chromosome:
8
Start:
144,876,497 bp from pter
End:
144,902,305 bp from pter
Size:
25,809 bases
Orientation:
Minus strand

Genomic View for ZNF250 Gene

Genes around ZNF250 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF250 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF250 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF250 Gene

Proteins for ZNF250 Gene

  • Protein details for ZNF250 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15622-ZN250_HUMAN
    Recommended name:
    Zinc finger protein 250
    Protein Accession:
    P15622
    Secondary Accessions:
    • D3DWP1
    • Q59HE9
    • Q8N942
    • Q96AH9

    Protein attributes for ZNF250 Gene

    Size:
    560 amino acids
    Molecular mass:
    63468 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAD92047.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAA34358.1; Type=Frameshift; Positions=458, 488; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF250 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF250 Gene

Post-translational modifications for ZNF250 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF250 Gene

Domains & Families for ZNF250 Gene

Gene Families for ZNF250 Gene

Suggested Antigen Peptide Sequences for ZNF250 Gene

Graphical View of Domain Structure for InterPro Entry

P15622

UniProtKB/Swiss-Prot:

ZN250_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF250: view

Function for ZNF250 Gene

Molecular function for ZNF250 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF250 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF250: view
genes like me logo Genes that share phenotypes with ZNF250: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF250 Gene

Localization for ZNF250 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF250 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF250 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for ZNF250 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF250: view

Pathways & Interactions for ZNF250 Gene

SuperPathways for ZNF250 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF250: view

Pathways by source for ZNF250 Gene

2 Reactome pathways for ZNF250 Gene

Gene Ontology (GO) - Biological Process for ZNF250 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,IBA --
genes like me logo Genes that share ontologies with ZNF250: view

No data available for SIGNOR curated interactions for ZNF250 Gene

Drugs & Compounds for ZNF250 Gene

No Compound Related Data Available

Transcripts for ZNF250 Gene

Unigene Clusters for ZNF250 Gene

Zinc finger protein 250:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF250 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d ^ 9
SP1: -
SP2: - -
SP3: -
SP4: - - - - -
SP5: - -
SP6: - - - - -
SP7: - -

Relevant External Links for ZNF250 Gene

GeneLoc Exon Structure for
ZNF250
ECgene alternative splicing isoforms for
ZNF250

Expression for ZNF250 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF250 Gene

Protein differential expression in normal tissues from HIPED for ZNF250 Gene

This gene is overexpressed in Fetal heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF250 Gene



Protein tissue co-expression partners for ZNF250 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF250 Gene:

ZNF250

SOURCE GeneReport for Unigene cluster for ZNF250 Gene:

Hs.532277

Evidence on tissue expression from TISSUES for ZNF250 Gene

  • Nervous system(4.3)
  • Intestine(4.1)
genes like me logo Genes that share expression patterns with ZNF250: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF250 Gene

Orthologs for ZNF250 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZNF250 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF250 34 35
  • 99.82 (n)
rat
(Rattus norvegicus)
Mammalia Zfp647 34
  • 84.24 (n)
mouse
(Mus musculus)
Mammalia Zfp647 34 16 35
  • 82.52 (n)
dog
(Canis familiaris)
Mammalia ZNF250 34 35
  • 77.51 (n)
cow
(Bos Taurus)
Mammalia ZNF250 34
  • 77.13 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 37 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ADR1 37
Species where no ortholog for ZNF250 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF250 Gene

ENSEMBL:
Gene Tree for ZNF250 (if available)
TreeFam:
Gene Tree for ZNF250 (if available)

Paralogs for ZNF250 Gene

(534) SIMAP similar genes for ZNF250 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for ZNF250 Gene

genes like me logo Genes that share paralogs with ZNF250: view

Variants for ZNF250 Gene

Sequence variations from dbSNP and Humsavar for ZNF250 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000031593 -- 144,880,272(+) TGAAT(A/T)TGAGA utr-variant-3-prime
rs1000076720 -- 144,899,331(+) GTAAG(A/G)TGACT intron-variant
rs1000110741 -- 144,876,664(+) CCACT(C/T)TATGG downstream-variant-500B
rs1000346632 -- 144,886,795(+) TAACA(A/C)CTTCA intron-variant
rs1000518875 -- 144,901,123(+) AGGGA(C/T)CGAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF250 Gene

Variant ID Type Subtype PubMed ID
nsv1031737 CNV gain 25217958
nsv469809 CNV loss 16826518
nsv612969 CNV loss 21841781
nsv6450 CNV insertion 18451855

Variation tolerance for ZNF250 Gene

Residual Variation Intolerance Score: 23.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.70; 32.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF250 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF250

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF250 Gene

Disorders for ZNF250 Gene

Relevant External Links for ZNF250

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF250

No disorders were found for ZNF250 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF250 Gene

Publications for ZNF250 Gene

  1. The ancient mammalian KRAB zinc finger gene cluster on human chromosome 8q24.3 illustrates principles of C2H2 zinc finger evolution associated with unique expression profiles in human tissues. (PMID: 20346131) Lorenz P. … Thiesen H.J. (BMC Genomics 2010) 2 3 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability. (PMID: 25755297) Xiao Z. … Vertegaal A.C. (Mol. Cell. Proteomics 2015) 4 64

Products for ZNF250 Gene

Sources for ZNF250 Gene

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