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Aliases for ZNF25 Gene

Aliases for ZNF25 Gene

  • Zinc Finger Protein 25 2 3 5
  • Zinc Finger Protein 25 (KOX 19) 2 3
  • Zinc Finger Protein KOX19 3 4
  • KOX19 3 4
  • Zfp9 3

External Ids for ZNF25 Gene

Previous GeneCards Identifiers for ZNF25 Gene

  • GC10U990058
  • GC10M038389
  • GC10M038242
  • GC10M038122
  • GC10M038278
  • GC10M038238

Summaries for ZNF25 Gene

GeneCards Summary for ZNF25 Gene

ZNF25 (Zinc Finger Protein 25) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF248.

UniProtKB/Swiss-Prot for ZNF25 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF25 Gene

Genomics for ZNF25 Gene

Regulatory Elements for ZNF25 Gene

Promoters for ZNF25 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF25 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF25 Gene

Chromosome:
10
Start:
37,949,572 bp from pter
End:
37,976,980 bp from pter
Size:
27,409 bases
Orientation:
Minus strand

Genomic View for ZNF25 Gene

Genes around ZNF25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF25 Gene

Proteins for ZNF25 Gene

  • Protein details for ZNF25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17030-ZNF25_HUMAN
    Recommended name:
    Zinc finger protein 25
    Protein Accession:
    P17030
    Secondary Accessions:
    • A9Z1X5
    • Q8IYE3
    • Q8NDD6
    • Q96MU2

    Protein attributes for ZNF25 Gene

    Size:
    456 amino acids
    Molecular mass:
    53545 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH36038.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF25 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF25 Gene

Proteomics data for ZNF25 Gene at MOPED

Post-translational modifications for ZNF25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF25 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF25 Gene

Domains & Families for ZNF25 Gene

Gene Families for ZNF25 Gene

Protein Domains for ZNF25 Gene

Suggested Antigen Peptide Sequences for ZNF25 Gene

Graphical View of Domain Structure for InterPro Entry

P17030

UniProtKB/Swiss-Prot:

ZNF25_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 12 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 12 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF25: view

Function for ZNF25 Gene

Molecular function for ZNF25 Gene

GENATLAS Biochemistry:
zinc finger protein 25 (KOX19) (C2H2 type,Kruppel-like)
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF25: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF25 Gene

Localization for ZNF25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF25 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF25 Gene COMPARTMENTS Subcellular localization image for ZNF25 gene
Compartment Confidence
nucleus 5
cytosol 3
golgi apparatus 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF25 Gene

Pathways & Interactions for ZNF25 Gene

SuperPathways for ZNF25 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF25: view

Pathways by source for ZNF25 Gene

2 Reactome pathways for ZNF25 Gene

Gene Ontology (GO) - Biological Process for ZNF25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF25: view

No data available for SIGNOR curated interactions for ZNF25 Gene

Drugs & Compounds for ZNF25 Gene

No Compound Related Data Available

Transcripts for ZNF25 Gene

Unigene Clusters for ZNF25 Gene

Zinc finger protein 25:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF25 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
SP1: - - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - - -
SP5:
SP6: - - -

Relevant External Links for ZNF25 Gene

GeneLoc Exon Structure for
ZNF25
ECgene alternative splicing isoforms for
ZNF25

Expression for ZNF25 Gene

mRNA expression in normal human tissues for ZNF25 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for ZNF25 Gene Hs.499429

genes like me logo Genes that share expression patterns with ZNF25: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZNF25 Gene

Orthologs for ZNF25 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF25 35
  • 99.27 (n)
  • 98.9 (a)
ZNF25 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF25 36
  • 83 (a)
OneToOne
ZNF25 35
  • 87.93 (n)
  • 84 (a)
dog
(Canis familiaris)
Mammalia ZNF25 35
  • 87.48 (n)
  • 85.78 (a)
ZNF25 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp9 16
Zfp9 36
  • 79 (a)
OneToOne
Zfp9 35
  • 81.64 (n)
  • 78.85 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 41 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
-- 36
  • 36 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 35 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Zfp9 35
  • 82.56 (n)
  • 78.46 (a)
Species with no ortholog for ZNF25:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF25 Gene

ENSEMBL:
Gene Tree for ZNF25 (if available)
TreeFam:
Gene Tree for ZNF25 (if available)

Paralogs for ZNF25 Gene

(519) SIMAP similar genes for ZNF25 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF25: view

Variants for ZNF25 Gene

Sequence variations from dbSNP and Humsavar for ZNF25 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
VAR_035567 A breast cancer sample
VAR_035568 A breast cancer sample
rs1208606 - 37,952,139(+) TCAGC(A/C)TTCCT reference, missense
rs766362 -- 37,961,278(+) TTAAA(C/G)CAACA intron-variant
rs1208602 -- 37,949,808(+) TGGCC(A/G)TTGAT downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF25 Gene

Variant ID Type Subtype PubMed ID
nsv895030 CNV Loss 21882294

Variation tolerance for ZNF25 Gene

Residual Variation Intolerance Score: 56.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.86; 17.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF25 Gene

HapMap Linkage Disequilibrium report
ZNF25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF25 Gene

Disorders for ZNF25 Gene

Relevant External Links for ZNF25

Genetic Association Database (GAD)
ZNF25
Human Genome Epidemiology (HuGE) Navigator
ZNF25
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF25

No disorders were found for ZNF25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF25 Gene

Publications for ZNF25 Gene

  1. Duplicated KOX zinc finger gene clusters flank the centromere of human chromosome 10: evidence for a pericentric inversion during primate evolution. (PMID: 8464732) Tunnacliffe A. … Ponder B.A. (Nucleic Acids Res. 1993) 2 3 23 67
  2. A cluster of expressed zinc finger protein genes in the pericentromeric region of human chromosome 10. (PMID: 1639412) Rousseau-Merck M.F. … Thiesen H.J. (Genomics 1992) 2 3
  3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3

Products for ZNF25 Gene

Sources for ZNF25 Gene

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