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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF25 Gene

protein-coding   GIFtS: 54
GCID: GC10M038238

Zinc Finger Protein 25

(Previous name: zinc finger protein 25 (KOX 19))
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 251 2
KOX192 3 5
Zinc Finger Protein 25 (KOX 19)1 2
Zinc Finger Protein KOX192 3
Zfp92

External Ids:    HGNC: 130431   Entrez Gene: 2197492   Ensembl: ENSG000001753957   OMIM: 1945285   UniProtKB: P170303   

Export aliases for ZNF25 gene to outside databases

Previous GC identifers: GC10U990058 GC10M037982 GC10M038389 GC10M038242 GC10M038122 GC10M038278


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF25 Gene: 
ZNF25 (zinc finger protein 25) is a protein-coding gene. Diseases associated with ZNF25 include sipple syndrome, and alzheimer's disease, and among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF577.

UniProtKB/Swiss-Prot: ZNF25_HUMAN, P17030
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_008705.16  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF25 gene promoter:
         USF1   ATF-2   XBP-1   Max   CRE-BP1   GCNF-1   USF-1   GCNF-2   c-Myc   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF25 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF25

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF25


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p11.1   Ensembl cytogenetic band:  10p11.1   HGNC cytogenetic band: 10p11.2

ZNF25 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF25 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M038238:  view genomic region     (about GC identifiers)

Start:
38,238,500 bp from pter      End:
38,265,561 bp from pter
Size:
27,062 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZNF25_HUMAN, P17030 (See protein sequence)
Recommended Name: Zinc finger protein 25  
Size: 456 amino acids; 53545 Da
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=AAH36038.1; Type=Erroneous initiation;
Secondary accessions: A9Z1X5 Q8IYE3 Q8NDD6 Q96MU2
Alternative splicing: 2 isoforms:  P17030-1   P17030-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF25: NX_P17030

Explore proteomics data for ZNF25 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P17030

  • ZNF25 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF25 Protein Expression
    REFSEQ proteins: NP_659448.1  
    ENSEMBL proteins: 
     ENSP00000302222  
    Reactome Protein details: P17030
    Human Recombinant Protein Products for ZNF25: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZNF25 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF25 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry P17030

    ProtoNet protein and cluster: P17030

    2 Blocks protein domains:
    IPB001909 KRAB box
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZNF25_HUMAN, P17030
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 12 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF25 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZNF25_HUMAN, P17030
    Function: May be involved in transcriptional regulation

         Genatlas biochemistry entry for ZNF25:
    zinc finger protein 25 (KOX19) (C2H2 type,Kruppel-like)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF25 for ontologies           About GeneDecksing


    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidZNF25 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF25 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF25
        Generic Transcription Pathway
    Gene Expression



    ZNF25 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF25

    5/20 Interacting proteins for ZNF25 (P170302) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000212866P081072MINT-8373408
    ENSG00000215328P081072MINT-8373408
    ENSG00000224501P081072MINT-8373408
    ENSG00000231555P081072MINT-8373408
    ENSG00000232804P081072MINT-8373408
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF25 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF25

    Search CenterWatch for drugs/clinical trials and news about ZNF25

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF25 gene: 
    NM_145011.2  

    Unigene Cluster for ZNF25:

    Zinc finger protein 25
    Hs.499429  [show with all ESTs]
    Unigene Representative Sequence: AL834125
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000302609(uc001ize.1 uc001izf.1) ENST00000374633 ENST00000467975


    miRNA
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    hsa-miR-2052 hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-124 hsa-miR-372 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidZNF25 3' UTR sequence
    Inhib. RNA
    Products:
         
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF25
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF25

    Additional mRNA sequence: 

    AJ491696.1 AK056452.1 AK056635.1 AK091378.1 AK122958.1 AL834125.1 AL834244.1 BC036038.1 
    X52350.1 

    8 DOTS entries:

    DT.100751782  DT.454663  DT.100020317  DT.101965723  DT.121224039  DT.121224041  DT.121224046  DT.121224038 

    24/86 AceView cDNA sequences (see all 86):

    BM978506 AK056452 CF995571 AI581270 AA588446 AJ491696 AA161185 CA429716 
    AL834125 AA931223 AA384510 AK091378 AA634248 CB156540 BQ008518 NM_145011 
    AI246339 CR600171 AK056635 AA447427 X52350 CD723372 AA406460 AW193304 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF25 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
    SP1:        -     -           -     -           -                                 
    SP2:        -     -           -     -     -     -                                 
    SP3:                          -     -     -     -                                 
    SP4:                                -     -     -                                 
    SP5:                                                                              


    ECgene alternative splicing isoforms for ZNF25

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF25 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTCAGAAAT
    ZNF25 Expression
    About this image


    See ZNF25 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF25

    SOURCE GeneReport for Unigene cluster: Hs.499429
        SABiosciences Custom PCR Arrays for ZNF25
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF25 gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp91 , 5 zinc finger protein 91, 5 81.64(n)1
    78.85(a)1
      6 (55.86 cM)5
    227501  NM_011763.21  NP_035893.11 
     1184619505 
    rainbow trout
    (Oncorhynchus mykiss)
    Actinopterygii BX874634.12   -- 72.47(n)    BX874634.1 


    ENSEMBL Gene Tree for ZNF25 (if available)
    TreeFam Gene Tree for ZNF25 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF25 gene
    ZNF5772  ZFP12  ZNF1572  ZNF3502  ENSG000002568252  
    18/520 SIMAP similar genes for ZNF25 using alignment to 2 protein entries:     ZNF25_HUMAN (see all proteins) (see all similar genes):
    ZNF818P    ZFS-4    ZFS-5    ZNF78L1    DKFZp666C237    HZF36
    DKFZp313M0722    ZFP2    ZNF180    ZNF323    ZNF72    ZNF33A
    DKFZp686M04222    ZFP37    ZFS-6    ZNF55    DKFZp666M039    HZF30

    ZNF25 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/606 SNPs in ZNF25 are shown (see all 606)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0355684
    A breast cancer sample4--see VAR_0355682 D G mis40--------
    VAR_0355674
    A breast cancer sample4--see VAR_0355672 E K mis40--------
    rs3695756511,2
    C--38238308(+) TCTAC-/A/AA  
            
    AAAAA
    1 -- ds50010--------
    rs1930916491,2
    --38238333(+) AATTAA/GCCAGG 1 -- ds50010--------
    rs12086011,2
    C,F,A,H--38238334(+) ATTAGA/CCAGGT 1 -- ds50016Minor allele frequency- C:0.33NA WA 12
    rs1846840471,2
    --38238375(+) TCGGGA/GGGCTG 1 -- ds50010--------
    rs1891059561,2
    --38238389(+) TGGGAA/GAATTG 1 -- ds50010--------
    rs1165991041,2
    F--38238473(+) GACCCC/TGCCAC 1 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1118732751,2
    C,F--38238474(+) ACCCCG/ACCACA 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1378585021,2
    C--38238592(+) CAATAA/CTTTTA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for ZNF25 (38238500 - 38265561 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZNF25:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv895030CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 194528    OMIM disorders: --

    2 diseases for ZNF25:    About MalaCards
    sipple syndrome    alzheimer's disease

    1 disease from the University of Copenhagen DISEASES database for ZNF25:
    Sipple syndrome

    ZNF25 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): ZNF25
    Human Genome Epidemiology (HuGE) Navigator: ZNF25 (1 document)

    Export disorders for ZNF25 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF25 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with ZNF25)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Duplicated KOX zinc finger gene clusters flank the centromere of human chromosome 10: evidence for a pericentric inversion during primate evolution. (PubMed id 8464732)1, 3, 9 Tunnacliffe A.... Ponder B.A. (1993)
    2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. A cluster of expressed zinc finger protein genes in the pericentromeric region of human chromosome 10. (PubMed id 1639412)1, 3 Rousseau-Merck M.F....Thiesen H.J. (1992)
    6. Multiple genes encoding zinc finger domains are expressed in human T cells. (PubMed id 2288909)1, 2 Thiesen H.-J. (1990)
    7. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    8. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    9. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
    10. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)2 Deloukas P.... Rogers J. (2004)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 219749 HGNC: 13043 AceView: ZNF25 Ensembl:ENSG00000175395 euGenes: HUgn219749
    ECgene: ZNF25 H-InvDB: ZNF25

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF25 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF25 gene:
    Search GeneIP for patents involving ZNF25

    GeneCards and IP:
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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