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Aliases for ZNF248 Gene

Aliases for ZNF248 Gene

  • Zinc Finger Protein 248 2 3
  • Kruppel-Type Zinc Finger Protein 3
  • BA162G10.3 (Zinc Finger Protein) 3
  • KRAB Protein Domain 3
  • BA162G10.3 3

External Ids for ZNF248 Gene

Summaries for ZNF248 Gene

GeneCards Summary for ZNF248 Gene

ZNF248 (Zinc Finger Protein 248) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF182.

UniProtKB/Swiss-Prot for ZNF248 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF248 Gene

Genomics for ZNF248 Gene

Genomic Location for ZNF248 Gene

Start:
37,744,363 bp from pter
End:
37,858,106 bp from pter
Size:
113,744 bases
Orientation:
Minus strand

Genomic View for ZNF248 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF248 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF248 Gene

Regulatory Elements for ZNF248 Gene

Proteins for ZNF248 Gene

  • Protein details for ZNF248 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NDW4-ZN248_HUMAN
    Recommended name:
    Zinc finger protein 248
    Protein Accession:
    Q8NDW4
    Secondary Accessions:
    • Q8NDV8
    • Q9UMP3

    Protein attributes for ZNF248 Gene

    Size:
    579 amino acids
    Molecular mass:
    67087 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF248 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF248 Gene

Proteomics data for ZNF248 Gene at MOPED

Post-translational modifications for ZNF248 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF248 Gene

Domains for ZNF248 Gene

Gene Families for ZNF248 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

UniProtKB/Swiss-Prot:

ZN248_HUMAN
Domain:
  • Contains 1 KRAB domain.:
    • Q8NDW4
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.:
    • Q8NDW4
Similarity:
  • Contains 8 C2H2-type zinc fingers.:
    • Q8NDW4
genes like me logo Genes that share domains with ZNF248: view

Function for ZNF248 Gene

Molecular function for ZNF248 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF248 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF248: view

miRNA for ZNF248 Gene

miRTarBase miRNAs that target ZNF248

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF248 Gene

Localization for ZNF248 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF248 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF248 Gene COMPARTMENTS Subcellular localization image for ZNF248 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF248 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF248: view

Pathways for ZNF248 Gene

SuperPathways for ZNF248 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF248: view

Pathways by source for ZNF248 Gene

2 Reactome pathways for ZNF248 Gene

Interacting Proteins for ZNF248 Gene

Gene Ontology (GO) - Biological Process for ZNF248 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF248: view

Transcripts for ZNF248 Gene

Unigene Clusters for ZNF248 Gene

Zinc finger protein 248:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF248 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10
SP1: - - - - - -
SP2: - - - -
SP3: - - - - - -
SP4: - -
SP5: - - - -
SP6: - - - -
SP7: - - -
SP8: -
SP9:

Relevant External Links for ZNF248 Gene

GeneLoc Exon Structure for
ZNF248
ECgene alternative splicing isoforms for
ZNF248

Expression for ZNF248 Gene

mRNA expression in normal human tissues for ZNF248 Gene

SOURCE GeneReport for Unigene cluster for ZNF248 Gene Hs.528423

genes like me logo Genes that share expressions with ZNF248: view

Orthologs for ZNF248 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF248 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF248 36
  • 99.71 (n)
  • 99.31 (a)
ZNF248 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF248 36
  • 88.18 (n)
  • 83.04 (a)
ZNF248 37
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF248 36
  • 86.51 (n)
  • 82.87 (a)
ZNF248 37
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp248 36
  • 79.51 (n)
  • 75.17 (a)
Zfp248 16
Zfp248 37
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp248 36
  • 81.02 (n)
  • 75 (a)
Species with no ortholog for ZNF248:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF248 Gene

ENSEMBL:
Gene Tree for ZNF248 (if available)
TreeFam:
Gene Tree for ZNF248 (if available)

Paralogs for ZNF248 Gene

Selected SIMAP similar genes for ZNF248 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for ZNF248 Gene

genes like me logo Genes that share paralogs with ZNF248: view

Variants for ZNF248 Gene

Sequence variations from dbSNP and Humsavar for ZNF248 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs200903 -- 37,812,650(+) gcccc(C/T)ggcca intron-variant
rs200904 -- 37,812,698(+) gtggt(C/T)tatgt intron-variant
rs200905 -- 37,812,870(+) gatgg(C/G)gtgac intron-variant
rs200906 -- 37,813,008(+) gagat(C/T)gtgga intron-variant
rs200907 -- 37,815,559(+) tatct(C/T)ttagc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF248 Gene

Variant ID Type Subtype PubMed ID
nsv895030 CNV Loss 21882294
esv1183366 CNV Insertion 17803354

Relevant External Links for ZNF248 Gene

HapMap Linkage Disequilibrium report
ZNF248

Disorders for ZNF248 Gene

Relevant External Links for ZNF248

Genetic Association Database (GAD)
ZNF248
Human Genome Epidemiology (HuGE) Navigator
ZNF248
genes like me logo Genes that share disorders with ZNF248: view

No data available for UniProtKB/Swiss-Prot for ZNF248 Gene

Publications for ZNF248 Gene

  1. Genomic sequence and transcriptional profile of the boundary between pericentromeric satellites and genes on human chromosome arm 10p. (PMID: 12566394) Guy J. … Jackson M.S. (Genome Res. 2003) 2 3 4
  2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 49
  3. Common body mass index-associated variants confer risk of extreme obesity. (PMID: 19553259) Cotsapas C. … Daly M.J. (Hum. Mol. Genet. 2009) 3 49
  4. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PMID: 22505724) Udeshi N.D. … Carr S.A. (Mol. Cell Proteomics 2012) 3
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3

Products for ZNF248 Gene

Sources for ZNF248 Gene

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