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Aliases for ZNF248 Gene

Aliases for ZNF248 Gene

  • Zinc Finger Protein 248 2 3 5
  • Kruppel-Type Zinc Finger Protein 3
  • BA162G10.3 (Zinc Finger Protein) 3
  • KRAB Protein Domain 3
  • BA162G10.3 3

External Ids for ZNF248 Gene

Previous GeneCards Identifiers for ZNF248 Gene

  • GC00U990515
  • GC10M038121
  • GC10M038157
  • GC10M038131
  • GC10M037825
  • GC10M038091

Summaries for ZNF248 Gene

GeneCards Summary for ZNF248 Gene

ZNF248 (Zinc Finger Protein 248) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF182.

UniProtKB/Swiss-Prot for ZNF248 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF248 Gene

Genomics for ZNF248 Gene

Regulatory Elements for ZNF248 Gene

Enhancers for ZNF248 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF248 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF248 Gene

37,744,363 bp from pter
37,860,851 bp from pter
116,489 bases
Minus strand

Genomic View for ZNF248 Gene

Genes around ZNF248 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF248 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF248 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF248 Gene

Proteins for ZNF248 Gene

  • Protein details for ZNF248 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 248
    Protein Accession:
    Secondary Accessions:
    • Q8NDV8
    • Q9UMP3

    Protein attributes for ZNF248 Gene

    579 amino acids
    Molecular mass:
    67087 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF248 Gene


neXtProt entry for ZNF248 Gene

Proteomics data for ZNF248 Gene at MOPED

Post-translational modifications for ZNF248 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF248 Gene

Domains & Families for ZNF248 Gene

Gene Families for ZNF248 Gene

Protein Domains for ZNF248 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 8 C2H2-type zinc fingers.
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 8 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF248: view

Function for ZNF248 Gene

Molecular function for ZNF248 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF248: view

Animal Model Products

CRISPR Products

miRNA for ZNF248 Gene

miRTarBase miRNAs that target ZNF248

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF248 Gene

Localization for ZNF248 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF248 Gene

Subcellular locations from

Jensen Localization Image for ZNF248 Gene COMPARTMENTS Subcellular localization image for ZNF248 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF248 Gene

Pathways & Interactions for ZNF248 Gene

SuperPathways for ZNF248 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF248: view

Pathways by source for ZNF248 Gene

2 Reactome pathways for ZNF248 Gene

Interacting Proteins for ZNF248 Gene

Gene Ontology (GO) - Biological Process for ZNF248 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF248: view

No data available for SIGNOR curated interactions for ZNF248 Gene

Drugs & Compounds for ZNF248 Gene

No Compound Related Data Available

Transcripts for ZNF248 Gene

Unigene Clusters for ZNF248 Gene

Zinc finger protein 248:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF248 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10
SP1: - - - - - -
SP2: - - - -
SP3: - - - - - -
SP4: - -
SP5: - - - -
SP6: - - - -
SP7: - - -
SP8: -

Relevant External Links for ZNF248 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF248 Gene

mRNA expression in normal human tissues for ZNF248 Gene

SOURCE GeneReport for Unigene cluster for ZNF248 Gene Hs.528423

genes like me logo Genes that share expression patterns with ZNF248: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZNF248 Gene

Orthologs for ZNF248 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF248 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZNF248 35
  • 88.18 (n)
  • 83.04 (a)
ZNF248 36
  • 83 (a)
(Canis familiaris)
Mammalia ZNF248 35
  • 86.51 (n)
  • 82.87 (a)
ZNF248 36
  • 72 (a)
(Mus musculus)
Mammalia Zfp248 35
  • 79.51 (n)
  • 75.17 (a)
Zfp248 16
Zfp248 36
  • 75 (a)
(Pan troglodytes)
Mammalia ZNF248 35
  • 99.71 (n)
  • 99.31 (a)
ZNF248 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Zfp248 35
  • 81.02 (n)
  • 75 (a)
Species with no ortholog for ZNF248:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF248 Gene

Gene Tree for ZNF248 (if available)
Gene Tree for ZNF248 (if available)

Paralogs for ZNF248 Gene

(496) SIMAP similar genes for ZNF248 Gene using alignment to 6 proteins: Pseudogenes for ZNF248 Gene

genes like me logo Genes that share paralogs with ZNF248: view

Variants for ZNF248 Gene

Sequence variations from dbSNP and Humsavar for ZNF248 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs11011379 - 37,832,703(+) ATTTT(C/T)ACTAT intron-variant, reference, missense
rs1419246 -- 37,775,242(-) AAATA(C/G)GGAAA intron-variant
rs1619266 -- 37,766,002(-) ATCAG(C/T)GAGAC intron-variant
rs1620874 -- 37,765,836(-) CCTGA(C/T)CCCTT intron-variant
rs1620971 -- 37,765,799(-) GCCCT(C/G)CTTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF248 Gene

Variant ID Type Subtype PubMed ID
nsv895030 CNV Loss 21882294
esv1183366 CNV Insertion 17803354

Variation tolerance for ZNF248 Gene

Residual Variation Intolerance Score: 11% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.21; 24.35% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF248 Gene

Disorders for ZNF248 Gene

Relevant External Links for ZNF248

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF248 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF248 Gene

Publications for ZNF248 Gene

  1. Genomic sequence and transcriptional profile of the boundary between pericentromeric satellites and genes on human chromosome arm 10p. (PMID: 12566394) Guy J. … Jackson M.S. (Genome Res. 2003) 2 3 4 67
  2. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  3. Common body mass index-associated variants confer risk of extreme obesity. (PMID: 19553259) Cotsapas C. … Daly M.J. (Hum. Mol. Genet. 2009) 3
  4. Epigenetic gene silencing by the SRY protein is mediated by a KRAB-O protein that recruits the KAP1 co-repressor machinery. (PMID: 19850934) Peng H. … Rauscher F.J. (J. Biol. Chem. 2009) 23
  5. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3

Products for ZNF248 Gene

Sources for ZNF248 Gene