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Aliases for ZNF24 Gene

Aliases for ZNF24 Gene

  • Zinc Finger Protein 24 2 3 5
  • Zinc Finger And SCAN Domain-Containing Protein 3 3 4
  • Retinoic Acid Suppression Protein A 3 4
  • Zinc Finger Protein 24 (KOX 17) 2 3
  • Zinc Finger Protein KOX17 3 4
  • Zinc Finger Protein 191 3 4
  • ZNF191 3 4
  • ZSCAN3 3 4
  • KOX17 3 4
  • RSG-A 3 4
  • Zfp191 3

External Ids for ZNF24 Gene

Previous HGNC Symbols for ZNF24 Gene

  • ZNF191

Previous GeneCards Identifiers for ZNF24 Gene

  • GC18M032950
  • GC18M032735
  • GC18M032722
  • GC18M031167
  • GC18M031169
  • GC18M032912
  • GC18M029771

Summaries for ZNF24 Gene

GeneCards Summary for ZNF24 Gene

ZNF24 (Zinc Finger Protein 24) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is ZNF396.

UniProtKB/Swiss-Prot for ZNF24 Gene

  • Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5-TCAT-3 DNA sequence (By similarity). Has transcription repressor activity in vitro.

Gene Wiki entry for ZNF24 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF24 Gene

Genomics for ZNF24 Gene

Regulatory Elements for ZNF24 Gene

Enhancers for ZNF24 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18F035376 1.2 ENCODE 8.2 -31.7 -31720 1.5 ARID4B SIN3A FEZF1 ZNF48 GLIS2 ELK1 SP3 SP5 NCOA1 KAT8 ZNF396 ZNF24 GC18M035375 PIR58243
GH18F035289 1.1 ENCODE 8 +55.2 55188 2.3 HDGF PKNOX1 ARNT CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF397 ELP2 ZNF24 ZSCAN30 ZNF271P PIR53427 GC18M035301
GH18F035266 0.2 ENCODE 7.2 +77.8 77761 1.8 USF1 L3MBTL2 CEBPB REST ETS1 POLR2A ZBTB33 TRIM28 MGA ZSCAN30 ZNF24 ENSG00000274184 ENSG00000279989
GH18F035281 0.4 ENCODE 7 +63.0 62951 1.5 JUND JUN FOS ZNF24 ZNF396 MAPRE2 PIR57805 ENSG00000274184
GH18F035246 1.3 Ensembl ENCODE 6.8 +98.0 98038 1.6 CEBPB SPI1 ZNF24 MAPRE2 ZNF396 PIR50065 PIR48276
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZNF24 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF24 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001514224 1482 2001 PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 ZNF207

Genomic Location for ZNF24 Gene

Chromosome:
18
Start:
35,332,212 bp from pter
End:
35,345,482 bp from pter
Size:
13,271 bases
Orientation:
Minus strand

Genomic View for ZNF24 Gene

Genes around ZNF24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF24 Gene

Proteins for ZNF24 Gene

  • Protein details for ZNF24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17028-ZNF24_HUMAN
    Recommended name:
    Zinc finger protein 24
    Protein Accession:
    P17028
    Secondary Accessions:
    • O14754
    • Q53YE4
    • Q6ICR5
    • Q8IZN4

    Protein attributes for ZNF24 Gene

    Size:
    368 amino acids
    Molecular mass:
    42155 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ZNF24 Gene

    Alternative splice isoforms for ZNF24 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF24 Gene

Post-translational modifications for ZNF24 Gene

No data available for DME Specific Peptides for ZNF24 Gene

Domains & Families for ZNF24 Gene

Gene Families for ZNF24 Gene

Suggested Antigen Peptide Sequences for ZNF24 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P17028

UniProtKB/Swiss-Prot:

ZNF24_HUMAN :
  • Contains 1 SCAN box domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 4 C2H2-type zinc fingers.
Domain:
  • Contains 1 SCAN box domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 4 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF24: view

Function for ZNF24 Gene

Molecular function for ZNF24 Gene

GENATLAS Biochemistry:
zinc finger protein 24 (KOX17) (C2H2 type,Kruppel-like)
UniProtKB/Swiss-Prot Function:
Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5-TCAT-3 DNA sequence (By similarity). Has transcription repressor activity in vitro.

Gene Ontology (GO) - Molecular Function for ZNF24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA,TAS 2288909
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA,IBA --
GO:0005515 protein binding IPI 16169070
GO:0008270 zinc ion binding NAS 10585455
GO:0043565 sequence-specific DNA binding ISS --
genes like me logo Genes that share ontologies with ZNF24: view
genes like me logo Genes that share phenotypes with ZNF24: view

Animal Models for ZNF24 Gene

MGI Knock Outs for ZNF24:

Animal Model Products

miRNA for ZNF24 Gene

miRTarBase miRNAs that target ZNF24

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF24 Gene

Localization for ZNF24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF24 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF24 Gene COMPARTMENTS Subcellular localization image for ZNF24 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZNF24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
genes like me logo Genes that share ontologies with ZNF24: view

Pathways & Interactions for ZNF24 Gene

SuperPathways for ZNF24 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0042552 myelination ISS --
GO:0045892 negative regulation of transcription, DNA-templated IDA 10585455
genes like me logo Genes that share ontologies with ZNF24: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF24 Gene

Drugs & Compounds for ZNF24 Gene

(1) Drugs for ZNF24 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved Pharma 2231
genes like me logo Genes that share compounds with ZNF24: view

Transcripts for ZNF24 Gene

Unigene Clusters for ZNF24 Gene

Zinc finger protein 24:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF24 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b
SP1: - - -
SP2: - -
SP3: -
SP4:

Relevant External Links for ZNF24 Gene

GeneLoc Exon Structure for
ZNF24
ECgene alternative splicing isoforms for
ZNF24

Expression for ZNF24 Gene

mRNA expression in normal human tissues for ZNF24 Gene

Protein differential expression in normal tissues from HIPED for ZNF24 Gene

This gene is overexpressed in Blymphocyte (13.2), CD8 Tcells (11.9), NK cells (10.6), and Lung (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF24 Gene



Protein tissue co-expression partners for ZNF24 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF24 Gene:

ZNF24

SOURCE GeneReport for Unigene cluster for ZNF24 Gene:

Hs.514802

mRNA Expression by UniProt/SwissProt for ZNF24 Gene:

P17028-ZNF24_HUMAN
Tissue specificity: Expressed in many tissues except in heart.
genes like me logo Genes that share expression patterns with ZNF24: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZNF24 Gene

Orthologs for ZNF24 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF24 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF24 34 35
  • 99.82 (n)
dog
(Canis familiaris)
Mammalia ZNF24 34 35
  • 94.66 (n)
cow
(Bos Taurus)
Mammalia ZNF24 34 35
  • 93.66 (n)
mouse
(Mus musculus)
Mammalia Zfp191 34 35
  • 89.04 (n)
Zfp24 16
rat
(Rattus norvegicus)
Mammalia Zfp191 34
  • 88.95 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF24 35
  • 69 (a)
OneToOne
Species where no ortholog for ZNF24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF24 Gene

ENSEMBL:
Gene Tree for ZNF24 (if available)
TreeFam:
Gene Tree for ZNF24 (if available)

Paralogs for ZNF24 Gene

(276) SIMAP similar genes for ZNF24 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZNF24: view

Variants for ZNF24 Gene

Sequence variations from dbSNP and Humsavar for ZNF24 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1050189 -- 35,333,784(-) TACTT(G/T)TGTGG intron-variant, utr-variant-3-prime
rs1050232 -- 35,332,468(-) AAGTT(C/T)TGATG intron-variant, utr-variant-3-prime
rs1050236 -- 35,332,454(-) TTTTT(C/T)TGGAG intron-variant, utr-variant-3-prime
rs1050256 -- 35,332,341(-) CTGTT(C/T)TGATT intron-variant, utr-variant-3-prime
rs1050258 -- 35,332,314(-) ATTTT(C/T)TTATT intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF24 Gene

Variant ID Type Subtype PubMed ID
nsv1059793 CNV gain 25217958

Variation tolerance for ZNF24 Gene

Residual Variation Intolerance Score: 62% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.44; 28.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF24 Gene

Human Gene Mutation Database (HGMD)
ZNF24
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF24

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF24 Gene

Disorders for ZNF24 Gene

Relevant External Links for ZNF24

Genetic Association Database (GAD)
ZNF24
Human Genome Epidemiology (HuGE) Navigator
ZNF24
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF24

No disorders were found for ZNF24 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF24 Gene

Publications for ZNF24 Gene

  1. Identification of a functional nuclear localization signal mediating nuclear import of the zinc finger transcription factor ZNF24. (PMID: 24224020) Li J.Z. … Zhang J.P. (PLoS ONE 2013) 3 4 64
  2. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PMID: 20453000) Liu C.Y. … Christiani D.C. (Carcinogenesis 2010) 3 46 64
  3. A transcript profiling approach reveals the zinc finger transcription factor ZNF191 is a pleiotropic factor. (PMID: 19463170) Li J. … Zhang J. (BMC Genomics 2009) 3 22 64
  4. Zinc finger protein 191 (ZNF191/Zfp191) is necessary to maintain neural cells as cycling progenitors. (PMID: 19544452) Khalfallah O. … Nardelli J. (Stem Cells 2009) 3 22 64
  5. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J. … Comb M.J. (Nat. Biotechnol. 2005) 3 4 64

Products for ZNF24 Gene

Sources for ZNF24 Gene

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