ZNF24 Gene
protein-coding GIFtS: 55
GCID: GC18M032912
|
|
zinc finger protein 24(Previous name: zinc finger protein 24 (KOX 17) )
(Previous symbol: ZNF191)
| |
Aliases
for ZNF24 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 241 2 | | Retinoic Acid Suppression Protein A2 3 | | KOX171 2 3 | | Zinc Finger And SCAN Domain-Containing Protein 32 3 | | ZNF1911 2 3 | | Zinc Finger Protein 1912 3 | | ZSCAN31 2 3 | | Zinc Finger Protein KOX172 3 | | Zfp1911 2 | | RSG-A2 3 | | Zinc Finger Protein 24 (KOX 17)1 2 | | Lacks Zinc Finger Domain2 |
Export aliases for ZNF24 gene to outside databasesPrevious GC identifers: GC18M032950 GC18M032735 GC18M032722 GC18M031167 GC18M031169 GC18M029771 |
Summaries
for ZNF24 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZNF24_HUMAN, P17028Function: Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversionof oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS),involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3'DNA sequence (By similarity). Has transcription repressor activity in vitro
Gene Wiki entry for ZNF24
|
Genomic Views
for ZNF24 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000018.9 NC_018929.1 NT_010966.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF24 gene promoter:
GATA-3 AML1a ATF-2 Pax-6 Olf-1 GATA-2 GATA-1 YY1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF24
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF24 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 18q12 Ensembl cytogenetic band: 18q12.2 HGNC cytogenetic band: 18q12ZNF24 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 18 GeneLoc Exon Structure GeneLoc location for GC18M032912: view genomic region
(about GC identifiers)
Start:
|
32,912,176 bp from pter |
End:
|
32,925,446 bp from pter |
Size:
|
13,271 bases |
Orientation:
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minus strand |
|
Proteins
for ZNF24 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZNF24_HUMAN, P17028 (See
protein sequence)Recommended Name: Zinc finger protein 24 Size: 368 amino acids; 42155 Da
Subcellular location: Nucleus
2 PDB 3D structures from  and Proteopedia  for ZNF24:1X6E (3D)
3LHR (3D)
Secondary accessions: O14754 Q53YE4 Q6ICR5 Q8IZN4Alternative splicing: 2 isoforms: P17028-1 P17028-2 Explore the universe of human proteins at neXtProt for ZNF24: NX_P17028
Post-translational modifications:
Sumoylated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P17028
ZNF24 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_008896.2
ENSEMBL proteins: ENSP00000261332 ENSP00000467655 ENSP00000382015 ENSP00000467432 ENSP00000467608 ENSP00000467924
Human Recombinant Protein Products for ZNF24:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
ISS | -- |
ZNF24 for ontologies About GeneDecksing
ZNF24 Antibody Products:
Assay Products for ZNF24: |
Protein
Domains /
Families
for ZNF24 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF24 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P17028ProtoNet protein and cluster: P17028 2 Blocks protein families: IPB003309 Transcriptional regulator SCAN IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: ZNF24_HUMAN, P17028Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 4 C2H2-type zinc fingersSimilarity: Contains 1 SCAN box domain |
Function
for ZNF24 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: ZNF24_HUMAN, P17028Function: Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversionof oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS),involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3'DNA sequence (By similarity). Has transcription repressor activity in vitro Genatlas biochemistry entry for ZNF24:zinc finger protein 24 (KOX17) (C2H2 type,Kruppel-like)
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
ZNF24 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for ZNF24:
5 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Zfp191):
ZNF24 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-outs for ZNF24: Zfp191tm1Jifu Zfp191tm1.2Pop
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF24 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF24
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF24 |
|
Pathways & Interactions
for ZNF24 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF24
STRING Interaction
Network Preview (showing 5 interactants - click image to see 18)
5/67 Interacting proteins for ZNF24 (P170281, 2, 3 ENSP000002613324) via UniProtKB, MINT, STRING, and/or I2D (see all 67)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
ZNF24 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF24 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF24
1 HMDB Compound for ZNF24 About this table
Search CenterWatch for drugs/clinical trials and news about ZNF24
|
Transcripts
for ZNF24 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF24 gene: NM_006965.2 Unigene Cluster for ZNF24: Zinc finger protein 24 Hs.514802 [show with all ESTs]Unigene Representative Sequence: NM_0069656 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000261332(uc002kyt.2 uc002kys.2) ENST00000589881 ENST00000399061(uc002kyu.1)
ENST00000590140 ENST00000589539 ENST00000593130
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF24 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF24
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF24 (NM_006965) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF24 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF24 |
Additional cDNA sequence: AF038964.1 AF542097.1 AK021966.1 AK291246.1 BC003566.1 BC016801.1 BT006658.1 CR450328.1 U68536.1 X52348.1 11 DOTS entries: DT.451808 DT.97840332 DT.434655 DT.100786941 DT.100786936 DT.85104811 DT.97864168 DT.121086002 DT.87018226 DT.95148951 DT.92434783 24/388 AceView cDNA sequences (see all 388): BM932294 AA329892 AW419182 AL709272 BQ268916 BU156750 CA776216 AA336613 AA991333 AI015653 BI259717 AA234542 BM712760 T40051 AI458112 AW614759 AA768798 AU108045 X52348 T40973 AA973015 AA381122 N87662 H99376
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF24 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b |
|---|
|
| SP1: | | | | | - | | - | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZNF24
|
Expression
for ZNF24 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF24 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGTTCCTGG
About this image
See ZNF24 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF24
SOURCE GeneReport for Unigene cluster: Hs.514802
UniProtKB/Swiss-Prot: ZNF24_HUMAN, P17028Tissue specificity: Expressed in many tissues except in heart
SABiosciences Custom PCR Arrays for ZNF24
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF24
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF24 |
Orthologs
for ZNF24 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for ZNF24 (if available)
TreeFam Gene Tree for ZNF24 (if available) |
Paralogs
for ZNF24 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF24 gene
- ZNF4962 ZNF4492 ZNF4462 ZSCAN92 ZKSCAN12 ZNF3972 ZNF5002 ZNF2132
- ZSCAN302 ZNF2322 ZNF2022 ZNF2632 ZKSCAN42 ZNF1742 ZSCAN252 ZNF3962
- ZSCAN122 ZNF3942 ZSCAN212 ZSCAN232 ZNF1652 ZSCAN162 ZKSCAN82 ZSCAN312
- ZSCAN222 ZKSCAN32 ZNF182
18/277 SIMAP similar genes for ZNF24 using alignment to 4 protein entries: ZNF24_HUMAN (see all proteins)
(see all similar genes):ZNF818P ZNF78L1 DKFZp666C237 ZNF470 ZSCAN20 ZNF167
ZFS-4 ZNF286B ZNF300 ZNF329 ZNF551 ZNF79
DKFZp761O1618 ZFP41 ZIK1 ZNF271 ZNF34 ZNF572
ZNF24 for paralogs About GeneDecksing
|
Genomic Variants
for ZNF24 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 18 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF24 (32912176 - 32925446 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF24: --
Human Gene Mutation Database (HGMD): ZNF24
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF24 |
|
Disorders
/ Diseases
for ZNF24 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF24 for disorders About GeneDecksing
OMIM gene information: 194534
OMIM disorders: --
4  diseases for ZNF24: About MalaCardsfanconi's anemia anemia esophagitis adenocarcinoma
Human Genome Epidemiology (HuGE) Navigator: ZNF24 (1 document)
Export disorders for ZNF24 gene to outside databases
|
Publications
for ZNF24 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF24 gene, integrated from 9 sources (see all 40):
(articles sorted by number of sources associating them with ZNF24) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
- Systematic identification and analysis of mammalian small ubiquitin- like modifier substrates. (PubMed id 15561718)1, 2 Gocke C.B.... Kang J. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Molecular cloning of six novel Kruppel-like zinc finger genes from hematopoietic cells and identification of a novel transregulatory domain KRNB. (PubMed id 10585455)1, 2 Han Z.-G.... Chen Z. (1999)
- Multiple genes encoding zinc finger domains are expressed in human T cells. (PubMed id 2288909)1, 2 Thiesen H.-J. (1990)
- Chromosomal localization of two human zinc finger protein genes, ZNF24 (KOX17) and ZNF29 (KOX26), to 18q12 and 17p13-p12, respectively. (PubMed id 2004757)1, 9 Rousseau-Merck M.F....Thiesen H.J. (1991)
- Zinc finger protein 191 (ZNF191/Zfp191) is necessary to maintain neural cells as cycling progenitors. (PubMed id 19544452)1, 9 Khalfallah O....Nardelli J. (2009)
- A transcript profiling approach reveals the zinc fing er transcription factor ZNF191 is a pleiotropic factor. (PubMed id 19463170)1, 9 Li J....Zhang J. (2009)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
|
External Searches for ZNF24 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF24 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF24 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF24 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF24 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF24 gene:
Search GeneIP for patents involving ZNF24
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF24 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF24 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF24 |
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