ZNF239 Gene
protein-coding GIFtS: 52
GCID: GC10M044051
|
|
zinc finger protein 239
| |
Aliases
for ZNF239 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 2391 2 | | Zinc Finger Protein MOK-22 3 | | MOK21 2 3 5 | | Zinc Finger Protein (C2H2) Homologous To Mouse MOK-22 | | HOK-21 2 | | HOK23 | | Zinc Finger Protein HOK-22 3 | | |
Export aliases for ZNF239 gene to outside databasesPrevious GC identifers: GC10M043340 GC10M043520 GC10M043826 GC10M043335 GC10M043371 GC10M040579 |
Summaries
for ZNF239 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ZNF239:
MOK2 proteins are DNA- and RNA-binding proteins that are mainly associated with nuclear RNP components, including thenucleoli and extranucleolar structures (Arranz et al., 1997 (PubMed 9121460)).(supplied by OMIM, Mar 2008)
UniProtKB/Swiss-Prot: ZN239_HUMAN, Q16600Function: May be involved in transcriptional regulation
Gene Wiki entry for ZNF239
|
Genomic Views
for ZNF239 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_033985.7
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF239 gene promoter:
IRF-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF239
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF239 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q11.22-q11.23 Ensembl cytogenetic band: 10q11.21 HGNC cytogenetic band: 10q11.22-q11.23ZNF239 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M044051: view genomic region
(about GC identifiers)
Start:
|
44,051,792 bp from pter |
End:
|
44,070,066 bp from pter |
Size:
|
18,275 bases |
Orientation:
|
minus strand |
|
Proteins
for ZNF239 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN239_HUMAN, Q16600 (See
protein sequence)Recommended Name: Zinc finger protein 239 Size: 458 amino acids; 51591 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: Q5T1G9 Q8TAS5Explore the universe of human proteins at neXtProt for ZNF239: NX_Q16600
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q16600
ZNF239 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001092752.1 NP_001092753.1 NP_001092754.1 NP_005665.2
ENSEMBL proteins: ENSP00000307774 ENSP00000363569 ENSP00000398202 ENSP00000443907 ENSP00000341689
Human Recombinant Protein Products for ZNF239:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
ZNF239 for ontologies About GeneDecksing
ZNF239 Antibody Products:
Assay Products for ZNF239: |
Protein
Domains /
Families
for ZNF239 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF239 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q16600ProtoNet protein and cluster: Q16600 1 Blocks protein family: IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: ZN239_HUMAN, Q16600Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 9 C2H2-type zinc fingers |
Function
for ZNF239 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: ZN239_HUMAN, Q16600Function: May be involved in transcriptional regulation Genatlas biochemistry entry for ZNF239:Kruppel zinc finger protein 239,murine Mok2 homolog
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZNF239 for ontologies About GeneDecksing
Phenotypes:
2 GenomeRNAi human phenotypes for ZNF239:
Animal Models:
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF239 (see all 5)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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Synthesis Service for ZNF239 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF239 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF239 |
|
Pathways & Interactions
for ZNF239 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZNF239
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
5 Interacting proteins for ZNF239 (Q166003 ENSP000003077744) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF239 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF239 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF239
Search CenterWatch for drugs/clinical trials and news about ZNF239 / ZN239
|
Transcripts
for ZNF239 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF239 gene (4 alternative transcripts): NM_001099282.1 NM_001099283.1 NM_001099284.1 NM_005674.2 Unigene Cluster for ZNF239: Zinc finger protein 239 Hs.25040 [show with all ESTs]Unigene Representative Sequence: NM_0056746 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000306006(uc001jaw.4) ENST00000374446 ENST00000491188 ENST00000426961(uc009xmj.3)
ENST00000535642(uc009xmk.3) ENST00000339962(uc001jax.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF239 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF239 (see all 5)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 4): ZNF239 (NM_005674) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF239 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF239 |
Additional cDNA sequence: AK292013.1 BC026030.1 X82125.1 X82128.1 11 DOTS entries: DT.309913 DT.97776276 DT.100753492 DT.121218197 DT.100669685 DT.121218204 DT.95357990 DT.121218194 DT.121218201 DT.75135280 DT.75172408 24/34 AceView cDNA sequences (see all 34): BC026030 CR605759 BU151286 BQ889598 BX401287 AA402531 AI282397 BM142454 BX341529 X82125 BX341530 AL709847 NM_005674 BX376467 BF972810 AI675929 BM801682 BM273186 AI002289 BM263150 CK820209 BF972892 AI347320 BX283348
GeneLoc Exon Structure
5/14 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF239 (see all 14) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e | · | 7f | · | 7g | · | 7h | · | 7i | · | 7j | · | 7k |
|---|
|
| SP1: | | | | | | | | | | | - | | | | - | | - | | - | | - | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | - | | - | | - | | - | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | - | | - | | | | | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZNF239
|
Expression
for ZNF239 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF239 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See ZNF239 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF239
SOURCE GeneReport for Unigene cluster: Hs.25040
SABiosciences Custom PCR Arrays for ZNF239
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF239
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF239 |
Orthologs
for ZNF239 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZNF239 gene from 3/8 species (see all 8) About this table
ENSEMBL Gene Tree for ZNF239 (if available)
TreeFam Gene Tree for ZNF239 (if available) |
Paralogs
for ZNF239 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF239 gene
- ZNF2292 ZNF2232 ZNF2302 ENSG000000623702 ZNF1552 ZNF6642 ZNF2272 ZNF2342
- ZNF2242 ZNF2252 ZNF2262 ZNF2142 ZNF2222 ZNF2842 ENSG000002671732 ZNF452
- ZNF2352 ZNF2212 ENSG000002670222 ZNF2852 ZNF2332
18/483 SIMAP similar genes for ZNF239 using alignment to 1 protein entry: ZN239_HUMAN(see all similar genes):HZF36 ZNF664 ZFP41 ZNF211 ZNF78L1 zf30
DKFZp666C237 ZNF132 ZNF300 ZNF436 ZNF782 ZNF251
ZNF271 ZNF286B ZNF418 ZNF484 ZNF709 ZNF81
ZNF239 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ZNF239
PGOHUM00000259560
|
Genomic Variants
for ZNF239 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF239 (44051792 - 44070066 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF239: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF239 |
|
Disorders
/ Diseases
for ZNF239 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF239 for disorders About GeneDecksing
OMIM gene information: 601069
OMIM disorders: --
2  diseases for ZNF239: About MalaCardsrabies alzheimer's disease
1 disease from the University of Copenhagen DISEASES database for ZNF239:Rabies Human Genome Epidemiology (HuGE) Navigator: ZNF239 (5 documents)
Export disorders for ZNF239 gene to outside databases
|
Publications
for ZNF239 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF239 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with ZNF239) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human and mouse Kruppel-like (MOK2) orthologue genes encode two different zinc finger proteins. (PubMed id 8587123)1, 2, 3 Ernoult-Lange M.... Kress M. (1995)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
- Localization of zinc finger Mok2 gene to mouse chromosome 6, a new region of homology with human chromosome 19. (PubMed id 8903737)1, 3 Arranz V....Ernoult-Lange M. (1996)
- Human and mouse MOK2 proteins are associated with nuclear ribonucleoprotein components and bind specifically to RNA and DNA through their zinc finger domains. (PubMed id 9121460)1, 9 Arranz V....Ernoult-Lange M. (1997)
- Mislocalization of human transcription factor MOK2 in the presence of pathogenic mutations of lamin A/C. (PubMed id 17760566)1, 9 Dreuillet C....Ernoult-Lange M. (2008)
- Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
- Polymorphisms in predicted miRNA binding sites and os teoporosis. (PubMed id 20641033)1 Lei S.F....Deng H.W. (2011)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
|
External Searches for ZNF239 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF239 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF239 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF239 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF239 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF239 gene:
Search GeneIP for patents involving ZNF239
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF239 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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