Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF239 Gene

Aliases for ZNF239 Gene

  • Zinc Finger Protein 239 2 3 5
  • Zinc Finger Protein HOK-2 3 4
  • Zinc Finger Protein MOK-2 3 4
  • MOK2 3 4
  • Zinc Finger Protein (C2H2) Homologous To Mouse MOK-2 3
  • HOK-2 3
  • HOK2 4

External Ids for ZNF239 Gene

Previous GeneCards Identifiers for ZNF239 Gene

  • GC10M043340
  • GC10M043826
  • GC10M043335
  • GC10M043371
  • GC10M044051
  • GC10M040579

Summaries for ZNF239 Gene

Entrez Gene Summary for ZNF239 Gene

  • MOK2 proteins are DNA- and RNA-binding proteins that are mainly associated with nuclear RNP components, including the nucleoli and extranucleolar structures (Arranz et al., 1997 [PubMed 9121460]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ZNF239 Gene

ZNF239 (Zinc Finger Protein 239) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA binding. An important paralog of this gene is ZNF229.

UniProtKB/Swiss-Prot for ZNF239 Gene

  • May be involved in transcriptional regulation.

Gene Wiki entry for ZNF239 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF239 Gene

Genomics for ZNF239 Gene

Regulatory Elements for ZNF239 Gene

Enhancers for ZNF239 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF239 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF239 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF239 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the ZNF239 gene promoter:

Genomic Location for ZNF239 Gene

Chromosome:
10
Start:
43,556,344 bp from pter
End:
43,574,618 bp from pter
Size:
18,275 bases
Orientation:
Minus strand

Genomic View for ZNF239 Gene

Genes around ZNF239 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF239 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF239 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF239 Gene

Proteins for ZNF239 Gene

  • Protein details for ZNF239 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16600-ZN239_HUMAN
    Recommended name:
    Zinc finger protein 239
    Protein Accession:
    Q16600
    Secondary Accessions:
    • Q5T1G9
    • Q8TAS5

    Protein attributes for ZNF239 Gene

    Size:
    458 amino acids
    Molecular mass:
    51591 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF239 Gene

Proteomics data for ZNF239 Gene at MOPED

Post-translational modifications for ZNF239 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF239 Gene

No data available for DME Specific Peptides for ZNF239 Gene

Domains & Families for ZNF239 Gene

Gene Families for ZNF239 Gene

Protein Domains for ZNF239 Gene

Suggested Antigen Peptide Sequences for ZNF239 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16600

UniProtKB/Swiss-Prot:

ZN239_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 9 C2H2-type zinc fingers.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 9 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF239: view

Function for ZNF239 Gene

Molecular function for ZNF239 Gene

GENATLAS Biochemistry:
Kruppel zinc finger protein 239,murine Mok2 homolog
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF239 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ZNF239: view
genes like me logo Genes that share phenotypes with ZNF239: view

Animal Model Products

CRISPR Products

miRNA for ZNF239 Gene

miRTarBase miRNAs that target ZNF239

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF239 Gene

Localization for ZNF239 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF239 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF239 Gene COMPARTMENTS Subcellular localization image for ZNF239 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF239 Gene

Pathways & Interactions for ZNF239 Gene

SuperPathways for ZNF239 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF239 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZNF239 Gene

Drugs & Compounds for ZNF239 Gene

No Compound Related Data Available

Transcripts for ZNF239 Gene

Unigene Clusters for ZNF239 Gene

Zinc finger protein 239:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF239 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g · 7h · 7i · 7j · 7k
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - - -
SP7: - - -
SP8: - - -
SP9: -
SP10:
SP11: - - - - - - - - - -
SP12: -
SP13: - - - - - - - - -
SP14: - -

Relevant External Links for ZNF239 Gene

GeneLoc Exon Structure for
ZNF239
ECgene alternative splicing isoforms for
ZNF239

Expression for ZNF239 Gene

mRNA expression in normal human tissues for ZNF239 Gene

SOURCE GeneReport for Unigene cluster for ZNF239 Gene Hs.25040

genes like me logo Genes that share expression patterns with ZNF239: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZNF239 Gene

Orthologs for ZNF239 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF239 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF239 35
  • 83.66 (n)
  • 78.1 (a)
ZNF239 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF239 35
  • 86.87 (n)
  • 82.45 (a)
ZNF239 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp239 35
  • 86.13 (n)
  • 94.92 (a)
Zfp239 16
Zfp239 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZNF239 35
  • 99.56 (n)
  • 99.12 (a)
ZNF239 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 25 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 33 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii BX276122.1 36
  • 48 (a)
ManyToMany
BX324003.4 36
  • 49 (a)
ManyToMany
BX511066.4 36
  • 44 (a)
ManyToMany
BX537137.1 36
  • 47 (a)
ManyToMany
BX548067.3 36
  • 49 (a)
ManyToMany
BX649556.2 36
  • 52 (a)
ManyToMany
BX842593.1 36
  • 45 (a)
ManyToMany
BX901892.1 36
  • 48 (a)
ManyToMany
BX927193.1 36
  • 45 (a)
ManyToMany
BX950868.2 36
  • 49 (a)
ManyToMany
CABZ01001466.1 36
  • 45 (a)
ManyToMany
CABZ01017733.1 36
  • 39 (a)
ManyToMany
CABZ01028403.3 36
  • 46 (a)
ManyToMany
CR388052.2 36
  • 48 (a)
ManyToMany
CR759907.4 36
  • 47 (a)
ManyToMany
CU138542.1 36
  • 39 (a)
ManyToMany
si:ch211-178j18.2 36
  • 49 (a)
ManyToMany
si:ch211-208f21.2 36
  • 48 (a)
ManyToMany
si:ch211-209j12.3 36
  • 45 (a)
ManyToMany
si:ch211-231i17.4 36
  • 46 (a)
ManyToMany
si:ch211-79k12.2 36
  • 25 (a)
ManyToMany
si:dkey-146c18.5 36
  • 42 (a)
ManyToMany
si:dkey-156j15.1 36
  • 47 (a)
ManyToMany
si:dkey-264f17.4 36
  • 36 (a)
ManyToMany
si:dkey-285e18.6 36
  • 44 (a)
ManyToMany
si:dkey-28i19.1 36
  • 44 (a)
ManyToMany
si:dkey-3p4.8 36
  • 48 (a)
ManyToMany
si:dkey-7j22.4 36
  • 45 (a)
ManyToMany
zgc:173619 36
  • 47 (a)
ManyToMany
zgc:173619 36
  • 47 (a)
ManyToMany
zgc:173620 36
  • 47 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG2120 37
  • 35 (a)
CG1832 36
  • 20 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea eor-1 36
  • 11 (a)
OneToMany
Species with no ortholog for ZNF239:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ZNF239 Gene

ENSEMBL:
Gene Tree for ZNF239 (if available)
TreeFam:
Gene Tree for ZNF239 (if available)

Paralogs for ZNF239 Gene

(487) SIMAP similar genes for ZNF239 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for ZNF239 Gene

genes like me logo Genes that share paralogs with ZNF239: view

Variants for ZNF239 Gene

Sequence variations from dbSNP and Humsavar for ZNF239 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs2230660 - 43,557,565(-) GAGAG(C/G/T)TCATA reference, missense
rs2230661 - 43,557,455(-) ACGAA(G/T)GTAGT reference, missense
rs1128865 - 43,557,282(-) TGTGA(C/G)AAGTG reference, missense
rs1832472 -- 43,571,579(-) TCTGT(C/T)TCAAA intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs2999277 -- 43,556,453(+) GAACA(A/T)GTAGT utr-variant-3-prime

Variation tolerance for ZNF239 Gene

Residual Variation Intolerance Score: 61.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.23; 24.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF239 Gene

HapMap Linkage Disequilibrium report
ZNF239

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZNF239 Gene

Disorders for ZNF239 Gene

Relevant External Links for ZNF239

Genetic Association Database (GAD)
ZNF239
Human Genome Epidemiology (HuGE) Navigator
ZNF239
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF239

No disorders were found for ZNF239 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF239 Gene

Publications for ZNF239 Gene

  1. Human and mouse Kruppel-like (MOK2) orthologue genes encode two different zinc finger proteins. (PMID: 8587123) Ernoult-Lange M. … Kress M. (J. Mol. Evol. 1995) 2 3 4 67
  2. Mislocalization of human transcription factor MOK2 in the presence of pathogenic mutations of lamin A/C. (PMID: 17760566) Dreuillet C. … Ernoult-Lange M. (Biol. Cell 2008) 3 23
  3. Human and mouse MOK2 proteins are associated with nuclear ribonucleoprotein components and bind specifically to RNA and DNA through their zinc finger domains. (PMID: 9121460) Arranz V. … Ernoult-Lange M. (Mol. Cell. Biol. 1997) 3 23
  4. Localization of zinc finger Mok2 gene to mouse chromosome 6, a new region of homology with human chromosome 19. (PMID: 8903737) Arranz V. … Ernoult-Lange M. (Mamm. Genome 1996) 2 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for ZNF239 Gene

Sources for ZNF239 Gene

Content