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Aliases for ZNF239 Gene

Aliases for ZNF239 Gene

  • Zinc Finger Protein 239 2 3 5
  • Zinc Finger Protein HOK-2 3 4
  • Zinc Finger Protein MOK-2 3 4
  • MOK2 3 4
  • Zinc Finger Protein (C2H2) Homologous To Mouse MOK-2 3
  • HOK-2 3
  • HOK2 4

External Ids for ZNF239 Gene

Previous GeneCards Identifiers for ZNF239 Gene

  • GC10M043340
  • GC10M043826
  • GC10M043335
  • GC10M043371
  • GC10M044051
  • GC10M040579

Summaries for ZNF239 Gene

Entrez Gene Summary for ZNF239 Gene

  • MOK2 proteins are DNA- and RNA-binding proteins that are mainly associated with nuclear RNP components, including the nucleoli and extranucleolar structures (Arranz et al., 1997 [PubMed 9121460]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ZNF239 Gene

ZNF239 (Zinc Finger Protein 239) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA binding. An important paralog of this gene is ZNF214.

UniProtKB/Swiss-Prot for ZNF239 Gene

  • May be involved in transcriptional regulation.

Gene Wiki entry for ZNF239 Gene

Additional gene information for ZNF239 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF239 Gene

Genomics for ZNF239 Gene

Regulatory Elements for ZNF239 Gene

Enhancers for ZNF239 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H043392 2.1 FANTOM5 Ensembl ENCODE dbSUPER 13.2 +172.9 172929 18.3 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 NFYC ZNF32-AS2 BMS1 EIF3LP2 ZNF37BP ZNF33B ZNF32-AS1 HNRNPA3P1 HNRNPF ZNF32 LOC105378272
GH10H042781 1.2 ENCODE 21.2 +791.9 791858 2.2 ZFP64 FEZF1 DMAP1 YY1 ZNF143 ZNF548 SP3 NFYC ZC3H11A ZFP41 BMS1 ZNF32-AS2 HNRNPF ENSG00000273008 EIF3LP2 ZNF32-AS1 ZNF37BP ZNF239 ZNF32 RSU1P1
GH10H043572 1 ENCODE 20.1 -0.2 -186 3.9 ATF1 ARNT SIN3A YY1 ETS1 ZNF766 GLIS2 CBX5 ELK1 ZNF143 ZNF32-AS2 BMS1 ZNF239 ZNF33B ZNF32-AS1 ZNF487 CAP1P2
GH10H042865 1.1 Ensembl ENCODE 9.9 +708.0 707955 1.8 RB1 ZSCAN4 ZNF76 KLF17 ZNF2 RAD21 ZNF391 ZNF654 REST TFDP1 ZNF32-AS1 ZNF32-AS2 ENSG00000273008 ZNF37BP ZNF239 ENSG00000259869 BMS1 LOC441666 ZNF33B GC10P042865
GH10H043416 1.7 FANTOM5 ENCODE dbSUPER 4.4 +155.1 155075 6.1 MLX ZFP64 DMAP1 YY1 ZNF143 SP3 NFYC PPARGC1A MEF2D SSRP1 BMS1 ZNF32-AS2 EIF3LP2 LOC105378272 ZNF33B ZNF239 ENSG00000259869 HNRNPF CSGALNACT2 GC10M043420
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF239 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF239 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000027238 318 1401 ATF1 ARNT SIN3A YY1 ETS1 ZNF766 GLIS2 CBX5 ELK1 ZNF143

Transcription factor binding sites by QIAGEN in the ZNF239 gene promoter:

Genomic Locations for ZNF239 Gene

Genomic Locations for ZNF239 Gene
18,275 bases
Minus strand

Genomic View for ZNF239 Gene

Genes around ZNF239 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF239 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF239 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF239 Gene

Proteins for ZNF239 Gene

  • Protein details for ZNF239 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 239
    Protein Accession:
    Secondary Accessions:
    • Q5T1G9
    • Q8TAS5

    Protein attributes for ZNF239 Gene

    458 amino acids
    Molecular mass:
    51591 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF239 Gene

Post-translational modifications for ZNF239 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF239 Gene

Domains & Families for ZNF239 Gene

Gene Families for ZNF239 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF239 Gene

Suggested Antigen Peptide Sequences for ZNF239 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF239: view

Function for ZNF239 Gene

Molecular function for ZNF239 Gene

GENATLAS Biochemistry:
Kruppel zinc finger protein 239,murine Mok2 homolog
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF239 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IMP 11278819
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding IMP 11278819
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding TAS 9121460
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
genes like me logo Genes that share ontologies with ZNF239: view
genes like me logo Genes that share phenotypes with ZNF239: view

miRNA for ZNF239 Gene

miRTarBase miRNAs that target ZNF239

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF239 Gene

Localization for ZNF239 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF239 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF239 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF239 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF239: view

Pathways & Interactions for ZNF239 Gene

SuperPathways for ZNF239 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF239 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 11278819
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF239: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF239 Gene

Drugs & Compounds for ZNF239 Gene

No Compound Related Data Available

Transcripts for ZNF239 Gene

Unigene Clusters for ZNF239 Gene

Zinc finger protein 239:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF239 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g · 7h · 7i · 7j · 7k
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - - -
SP7: - - -
SP8: - - -
SP9: -
SP11: - - - - - - - - - -
SP12: -
SP13: - - - - - - - - -
SP14: - -

Relevant External Links for ZNF239 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF239 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF239 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF239 Gene:


SOURCE GeneReport for Unigene cluster for ZNF239 Gene:


Evidence on tissue expression from TISSUES for ZNF239 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with ZNF239: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF239 Gene

Orthologs for ZNF239 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF239 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF239 33 34
  • 99.56 (n)
(Canis familiaris)
Mammalia ZNF239 33 34
  • 86.87 (n)
(Mus musculus)
Mammalia Zfp239 33 16 34
  • 86.13 (n)
(Bos Taurus)
Mammalia ZNF239 33 34
  • 83.66 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 25 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 33 (a)
(Danio rerio)
Actinopterygii BX649556.2 34
  • 52 (a)
BX324003.4 34
  • 49 (a)
BX548067.3 34
  • 49 (a)
BX950868.2 34
  • 49 (a)
si:ch211-178j18.2 34
  • 49 (a)
BX276122.1 34
  • 48 (a)
BX901892.1 34
  • 48 (a)
CR388052.2 34
  • 48 (a)
si:ch211-208f21.2 34
  • 48 (a)
si:dkey-3p4.8 34
  • 48 (a)
BX537137.1 34
  • 47 (a)
CR759907.4 34
  • 47 (a)
si:dkey-156j15.1 34
  • 47 (a)
zgc:173619 34 34
  • 47 (a)
zgc:173620 34
  • 47 (a)
CABZ01028403.3 34
  • 46 (a)
si:ch211-231i17.4 34
  • 46 (a)
BX842593.1 34
  • 45 (a)
BX927193.1 34
  • 45 (a)
CABZ01001466.1 34
  • 45 (a)
si:ch211-209j12.3 34
  • 45 (a)
si:dkey-7j22.4 34
  • 45 (a)
BX511066.4 34
  • 44 (a)
si:dkey-285e18.6 34
  • 44 (a)
si:dkey-28i19.1 34
  • 44 (a)
si:dkey-146c18.5 34
  • 42 (a)
CABZ01017733.1 34
  • 39 (a)
CU138542.1 34
  • 39 (a)
si:dkey-264f17.4 34
  • 36 (a)
si:ch211-79k12.2 34
  • 25 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2120 35
  • 35 (a)
CG1832 34
  • 20 (a)
(Caenorhabditis elegans)
Secernentea eor-1 34
  • 11 (a)
Species where no ortholog for ZNF239 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ZNF239 Gene

Gene Tree for ZNF239 (if available)
Gene Tree for ZNF239 (if available)

Paralogs for ZNF239 Gene

(487) SIMAP similar genes for ZNF239 Gene using alignment to 1 proteins: Pseudogenes for ZNF239 Gene

genes like me logo Genes that share paralogs with ZNF239: view

Variants for ZNF239 Gene

Sequence variations from dbSNP and Humsavar for ZNF239 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000296369 -- 43,562,506(+) TGCAC(A/G)TTTTA intron-variant
rs1000340574 -- 43,575,542(+) GGCTA(C/G)TTCCT upstream-variant-2KB
rs1000374779 -- 43,575,906(+) GAGAG(A/G)CCCAC upstream-variant-2KB
rs1000667401 -- 43,569,697(+) TCTTA(C/T)AACTT intron-variant, upstream-variant-2KB
rs1000851307 -- 43,554,029(+) GCAAT(A/G)TTGGT downstream-variant-500B

Variation tolerance for ZNF239 Gene

Residual Variation Intolerance Score: 61.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.23; 24.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF239 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZNF239 Gene

Disorders for ZNF239 Gene

Relevant External Links for ZNF239

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF239 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF239 Gene

Publications for ZNF239 Gene

  1. Human and mouse Krüppel-like (MOK2) orthologue genes encode two different zinc finger proteins. (PMID: 8587123) Ernoult-Lange M … Kress M (Journal of molecular evolution 1995) 2 3 4 60
  2. Polymorphisms in predicted miRNA binding sites and osteoporosis. (PMID: 20641033) Lei SF … Deng HW (Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2011) 3 45 60
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60
  4. Mislocalization of human transcription factor MOK2 in the presence of pathogenic mutations of lamin A/C. (PMID: 17760566) Dreuillet C … Ernoult-Lange M (Biology of the cell 2008) 3 22 60
  5. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 45 60

Products for ZNF239 Gene

Sources for ZNF239 Gene

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