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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF236 Gene

protein-coding   GIFtS: 45
GCID: GC18P074536

zinc finger protein 236

 Explore 1 disease affiliated with
ZNF236 via our new
 Human Malady Compendium 
Biological research products
for ZNF236
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Zinc Finger Protein 2361 2
ZNF236A2
ZNF236B2
Regulated By Glucose2

External Ids:    HGNC: 130281   Entrez Gene: 77762   Ensembl: ENSG000001308567   OMIM: 6047605   UniProtKB: Q9UL363   

Export aliases for ZNF236 gene to outside databases

Previous GC identifers: GC18P074159 GC18P074689 GC18P074299 GC18P072663 GC18P071217


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZN236_HUMAN, Q9UL36
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NC_018929.1  NT_025028.14  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ZNF236
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF236 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF236

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF236


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q22-q23   Ensembl cytogenetic band:  18q23   HGNC cytogenetic band: 18q22-q23

ZNF236 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF236 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P074536:  view genomic region     (about GC identifiers)

Start:
74,534,563 bp from pter      End:
74,682,683 bp from pter
Size:
148,121 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZN236_HUMAN, Q9UL36 (See protein sequence)
Recommended Name: Zinc finger protein 236  
Size: 1845 amino acids; 203704 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: B2RTX9 Q9UL37
Alternative splicing: 2 isoforms:  Q9UL36-1   Q9UL36-2   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for ZNF236: NX_Q9UL36

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UL36

  • ZNF236 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_031371.3  
    ENSEMBL proteins: 
     ENSP00000322361   ENSP00000444524   ENSP00000253159   ENSP00000463787  

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    Uscn Proteins for ZNF236

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS--


    ZNF236 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ZNF236 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9UL36

    ProtoNet protein and cluster: Q9UL36

    UniProtKB/Swiss-Prot: ZN236_HUMAN, Q9UL36
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 30 C2H2-type zinc fingers


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ZN236_HUMAN, Q9UL36
    Function: May be involved in transcriptional regulation

         Genatlas biochemistry entry for ZNF236:
    zinc finger protein 236,(glucose regulated Kruppel-like),ubiquitously expressed

    miRNA
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    miRTarBase miRNAs that target ZNF236:
    hsa-mir-155 (MIRT005091)

    OriGene 3'-UTR Clone: ZNF236
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    8/87 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNF236 (see all 87):
    hsa-miR-520e hsa-miR-300 hsa-miR-106a hsa-miR-374a hsa-miR-519a hsa-miR-4275 hsa-miR-3142 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidZNF236 3' UTR sequence
    Inhib. RNA
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity NAS--
    GO:0008270zinc ion binding IEA--


    ZNF236 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF236

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent NAS--
    GO:0071333cellular response to glucose stimulus IEP9299475


    ZNF236 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF236
    Search CenterWatch for drugs/clinical trials and news about ZNF236 / ZN236 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF236 gene: 
    NM_007345.3  

    Unigene Cluster for ZNF236:

    Zinc finger protein 236
    Hs.719137  [show with all ESTs]
    Unigene Representative Sequence: NM_007345
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000320610 ENST00000543926(uc002lmj.3) ENST00000253159(uc002lmi.3)
    ENST00000579322(uc002lmk.1) ENST00000583095 ENST00000583488 ENST00000584565
    ENST00000581450

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    8/87 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNF236 (see all 87):
    hsa-miR-520e hsa-miR-300 hsa-miR-106a hsa-miR-374a hsa-miR-519a hsa-miR-4275 hsa-miR-3142 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidZNF236 3' UTR sequence
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF236
    OriGene shRNA RFP: ZNF236
    OriGene siRNA: ZNF236
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF236
    Clone
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    GenScript: all cDNA clones in your preferred vector: ZNF236 (NM_007345)
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF236
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF236

    Additional cDNA sequence: 

    AB208834.1 AF083213.1 AF085244.1 BC140859.1 BX648028.1 

    9 DOTS entries:

    DT.100812992  DT.209775  DT.95118448  DT.91950905  DT.92422923  DT.95266562  DT.91684551  DT.70101555 
    DT.97803070 

    24/66 AceView cDNA sequences (see all 66):

    CR599803 AI783463 AF083213 AW192251 T23550 AW190658 BE466654 F10412 
    BX648028 F09223 AW241529 CD251873 AW629086 BE548450 AI989339 AF085244 
    NM_007345 BQ022213 BG287737 BP354765 AF085243 AI628104 BM460178 CD518356 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF236 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TATAACCAGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See ZNF236 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF236

    SOURCE GeneReport for Unigene cluster: Hs.719137

    UniProtKB/Swiss-Prot: ZN236_HUMAN, Q9UL36
    Tissue specificity: Ubiquitous. Expression levels are highest in skeletal muscle and brain, intermediate in heart,
    pancreas, and placenta, and lowest in kidney, liver, and lung

        SABiosciences Custom PCR Arrays for ZNF236
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF236

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ZNF236 gene from 5/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves ZNF2361 zinc finger protein 236 74.88(n)
    84.02(a)
      421008  XM_419094.3  XP_419094.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    --
    79(a)
    31(a)
    1 ↔ 1
    possible ortholog
    4(50803141-50837072)
    4(50839365-50852051)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.52832 Xenopus laevis transcribed sequence with weak similarity more 75.39(n)    AW638487.1 
    zebrafish
    (Danio rerio)
    Actinopterygii znf2366
    zinc finger protein 236
    54(a)
    1 ↔ 1
    16(7964346-8014222)
    honey bee
    (Apis mellifera)
    Insecta --
    --
    25(a)
    1 ↔ 1
    Group11.1(75173-79973)


    ENSEMBL Gene Tree for ZNF236 (if available)
    TreeFam Gene Tree for ZNF236 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF236 gene
    SALL32  SALL22  SALL12  SALL42  
    18/112 SIMAP similar genes for ZNF236 using alignment to 3 protein entries:     ZN236_HUMAN (see all proteins) (see all similar genes):
    ZNF826P    kr-znf3    ZNF808    ZFS-4    ZNF55    ZNF78L1
    ZFS-5    HZF16    ZNF    DKFZp686N0199    DKFZp434J0650    ZNF468
    ZFS-6    ZFS-2    ZNF785    ZNF22    ZNFN1A2    ZNF263

    ZNF236 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2761 NCBI SNPs in ZNF236 are shown (see all 2761    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs775745311,2
    C,--74534336(+) GAACCC/TGCCAA 2 -- us2k10--------
    rs124579081,2
    C,A,H,--74535018(+) GGGGAG/AGCGGC 2 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1860501381,2
    --74535050(+) GGATAA/CCGCGC 2 -- us2k10--------
    rs1897197001,2
    --74535311(+) GTGGGC/TAGTGC 2 -- us2k10--------
    rs1490689731,2
    --74535320(+) GCATAC/TAGTAG 2 -- us2k10--------
    rs99629051,2
    C,F,--74535328(+) TAGGCG/ACCATT 2 -- us2k18Minor allele frequency- A:0.38NA CSA WA EA 368
    rs1834122911,2
    --74535352(+) CTGGAA/GCCCTG 2 -- us2k10--------
    rs1430758241,2
    --74535357(+) ACCCTA/GGGCAT 2 -- us2k10--------
    rs1877039061,2
    --74535379(+) TGTGGA/GTCGTG 2 -- us2k10--------
    rs1923384211,2
    --74535514(+) GTCAGA/GAAGTG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZNF236 (74534563 - 74682683 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 6 variations for ZNF236
         3 CNVs: 88947 88945 77952
         3 Indels: 102723 88946 102724

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZNF236 for disorders           About GeneDecksing

    OMIM gene information: 604760    OMIM disorders: --

    1 disease for ZNF236:    About MalaCards
    nephropathy

    Human Genome Epidemiology (HuGE) Navigator: ZNF236 (2 documents)

    Export disorders for ZNF236 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF236 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF236)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of ZNF236, a glucose-regulated kruppel- like zinc-finger gene mapping to human chromosome 18q22-q23. (PubMed id 10458916)1, 2, 3 Holmes D.I.... Mason R.M. (1999)
    2. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    3. Genetic analysis of diabetic nephropathy on chromosom e 18 in African Americans: linkage analysis and dense SNP mapping. (PubMed id 19690890)1 McDonough C.W....Bowden D.W. (2009)
    4. Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)1 Trynka G....Wijmenga C. (2009)
    5. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    6. DNA sequence and analysis of human chromosome 18. (PubMed id 16177791)2 Nusbaum C.... Lander E.S. (2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    8. The Kruppel-like zinc-finger gene ZNF236 is alternatively spliced and excluded as susceptibility gene for diabetic nephropathy. (PubMed id 12906866)1 Halama N....van der Woude F.J. (2003)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. Identification of glucose-regulated genes in human mesangial cells by mRNA differential display. (PubMed id 9299475)1 Holmes D.I.... Mason R.M. (1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7776 HGNC: 13028 AceView: ZNF236 Ensembl:ENSG00000130856 euGenes: HUgn7776
    ECgene: ZNF236 H-InvDB: ZNF236

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF236 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF236 gene:
    Search GeneIP for patents involving ZNF236

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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