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ZNF236 Gene

protein-coding   GIFtS: 43
GCID: GC18P074536

Zinc Finger Protein 236

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Aliases
for ZNF236 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 2361 2
ZNF236A2
ZNF236B2
Regulated By Glucose2

External Ids:    HGNC: 130281   Entrez Gene: 77762   Ensembl: ENSG000001308567   OMIM: 6047605   UniProtKB: Q9UL363   

Export aliases for ZNF236 gene to outside databases

Previous GC identifers: GC18P074159 GC18P074689 GC18P074299 GC18P072663 GC18P071217


Summaries
for ZNF236 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF236 Gene:
ZNF236 (zinc finger protein 236) is a protein-coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is SALL3.

UniProtKB/Swiss-Prot: ZN236_HUMAN, Q9UL36
Function: May be involved in transcriptional regulation




Genomic Views
for ZNF236 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus		 Regulatory elements:
   Search for regulatory transcription factor binding sites for ZNF236
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZNF236 promoter sequence
   Search Chromatin IP Primers for ZNF236

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF236


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q22-q23   Ensembl cytogenetic band:  18q23   HGNC cytogenetic band: 18q22-q23

ZNF236 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF236 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P074536:  view genomic region     (about GC identifiers)

Start:
 74,534,563 bp from pter      End:
 74,682,683 bp from pter
Size:
 148,121 bases      Orientation:
 plus strand

Proteins
for ZNF236 gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZN236_HUMAN, Q9UL36 (See protein sequence)
Recommended Name: Zinc finger protein 236  
Size: 1845 amino acids; 203704 Da
Secondary accessions: B2RTX9 Q9UL37
Alternative splicing: 2 isoforms:  Q9UL36-1   Q9UL36-2   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for ZNF236: NX_Q9UL36

Explore proteomics data for ZNF236 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

    • See ZNF236 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_031371.3  
    ENSEMBL proteins: 
     ENSP00000322361   ENSP00000444524   ENSP00000253159   ENSP00000463787  

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    Cloud-Clone Corp. Proteins for ZNF236

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         		antibodies-online peptides for ZNF236

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    antibodies-online antibodies for ZNF236 (4 products) 

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    Cloud-Clone Corp. ELISAs for ZNF236
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    antibodies-online kits for ZNF236 (2 products) 

    Domains /
    Families
    for ZNF236 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus    		 HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9UL36

    ProtoNet protein and cluster: Q9UL36

    UniProtKB/Swiss-Prot: ZN236_HUMAN, Q9UL36
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 30 C2H2-type zinc fingers


    Find genes that share domains with ZNF236           About GenesLikeMe


    Function
    for ZNF236 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN236_HUMAN, Q9UL36
    Function: May be involved in transcriptional regulation

         Genatlas biochemistry entry for ZNF236:
    zinc finger protein 236,(glucose regulated Kruppel-like),ubiquitously expressed

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity ----
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF236           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ZNF236

    miRNA
    Products:            		miRTarBase miRNAs that target ZNF236:
    hsa-mir-155-5p (MIRT005091), hsa-let-7e-5p (MIRT051497), hsa-mir-128-3p (MIRT021965), hsa-mir-132-3p (MIRT021847), hsa-mir-142-3p (MIRT021570)

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    Selected qRT-PCR Assays for microRNAs that regulate ZNF236 (see all 87):
    hsa-miR-520e hsa-miR-300 hsa-miR-106a hsa-miR-374a hsa-miR-519a hsa-miR-4275 hsa-miR-3142 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmid: ZNF236 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    In Situ Assay
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    Localization
    for ZNF236 gene

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN236_HUMAN, Q9UL36: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZNF236           About GenesLikeMe


    Pathways & Interactions
    for ZNF236 gene

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

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    Interactions:

        Search GeneGlobe Interaction Network for ZNF236

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0071333cellular response to glucose stimulus IEP9299475

    Find genes that share ontologies with ZNF236           About GenesLikeMe



    Drugs & Compounds
    for ZNF236 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF236 (ZN236)



    Transcripts
    for ZNF236 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF236 gene: 
    NM_007345.3  

    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000320610 ENST00000543926(uc002lmj.3) ENST00000253159(uc002lmi.3)
    ENST00000579322(uc002lmk.1) ENST00000583095 ENST00000583488 ENST00000584565
    ENST00000581450
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ZNF236 (see all 87):
    hsa-miR-520e hsa-miR-300 hsa-miR-106a hsa-miR-374a hsa-miR-519a hsa-miR-4275 hsa-miR-3142 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmid: ZNF236 3' UTR sequence
    Inhib. RNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat ZNF236
      QuantiFast Probe-based Assays in human, mouse, rat ZNF236

    Selected AceView cDNA sequences (see all 66):

    AF083213 AW190658 BE466654 F10412 CR599803 T23550 AW192251 AI783463 
    CD251873 BP354765 NM_007345 BX648028 BG287737 BQ022213 AF085243 CD518356 
    AI628104 BM460178 T39619 AF085244 AI653572 AI468588 BU852283 F11565 

    GeneLoc Exon Structure


    Expression
    for ZNF236 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    ZNF236 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATAACCAGG
    ZNF236 Expression
    About this image

    ZNF236 Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

    ZNF236 Protein Expression

    UniProtKB/Swiss-Prot: ZN236_HUMAN, Q9UL36
    Tissue specificity: Ubiquitous. Expression levels are highest in skeletal muscle and brain, intermediate in heart,
    pancreas, and placenta, and lowest in kidney, liver, and lung

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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF236

    Orthologs
    for ZNF236 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ZNF236 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Zfp2361 , 5 zinc finger protein 2361, 5 83.39(n)1
    88.66(a)1    		   18 (56.26 cM)5
    3290021  NM_177832.31  NP_808500.21 
     825935935 
    chicken
    (Gallus gallus)    		 Aves ZNF2361 zinc finger protein 236 74.84(n)
    84.02(a)    		   421008  XM_004935190.1  XP_004935247.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ZNF2366
    		 zinc finger protein 236
    		 78(a)
    		 1 ↔ 1
    		 4(50800946-50855756)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.52832 Xenopus laevis transcribed sequence with weak similarity more 75.39(n)    AW638487.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii znf2366
    		 zinc finger protein 236
    		 56(a)
    		 1 ↔ 1
    		 16(7964346-8014222) ENSDARG00000095890
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes FZF16
    		 Transcription factor involved in sulfite metabolis...
    		 23(a)
    		 1 → many
    		 VII(22304-23203) YGL254W


    ENSEMBL Gene Tree for ZNF236 (if available)
    TreeFam Gene Tree for ZNF236 (if available)

    Paralogs
    for ZNF236 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF236 gene
    SALL32  SALL22  SALL12  SALL42  
    Selected SIMAP similar genes for ZNF236 using alignment to 3 protein entries:     ZN236_HUMAN (see all proteins) (see all similar genes):
    ZNF826P    kr-znf3    ZNF808    ZFS-4    ZNF55    ZNF78L1
    ZFS-5    HZF16    ZNF    DKFZp686N0199    DKFZp434J0650    ZNF468
    ZFS-6    ZNF430    ZFS-2    ZNF785    ZNF22    ZNF737

    Find genes that share paralogs with ZNF236           About GenesLikeMe



    Genomic Variants
    for ZNF236 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF236 (see all 3305)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 18 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1162228381,2
    		C,F--71215955(+) CCCTCC/TGAGCC 1 -- us2k12Minor allele frequency- T:0.07WA EA 238
    rs105813681,2
    		C--71277018(+) ttttt-/T/T   
       T    /TTT    AAGTG     		1 -- int1 trp31NA 2
    rs2005918841,2
    		C--74536323(+) GCCTTT/CGTGGG 2 /R /C mis11Minor allele frequency- C:0.00EU 1323
    rs1505695341,2
    		C--74536358(+) CATGAC/TCCAGG 2 D syn10--------
    rs1911215281,2
    		--74536542(+) GTGCAA/GTGTCT 1 -- int10--------
    rs1395609951,2
    		C--74536550(+) TCTCAG/TTTACT 1 -- int10--------
    rs766541231,2
    		C--74536593(+) AAATTC/TCCACG 1 -- int10--------
    rs116596891,2
    		H--74536721(+) ACTTCA/CTAATT 1 -- int10--------
    rs1500201771,2
    		--74536814(+) TCCCTC/TTCCGG 1 -- int10--------
    rs739682151,2
    		C,F--74536839(+) GGAGCC/TCCCTT 1 -- int12Minor allele frequency- T:0.04WA 120

    HapMap Linkage Disequilibrium report for ZNF236 (74534563 - 74682683 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for ZNF236:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2717388CNV Deletion23290073
    esv2588513CNV Deletion19546169
    esv2717423CNV Deletion23290073
    esv2717421CNV Deletion23290073
    esv2717422CNV Deletion23290073
    esv2547601CNV Insertion19546169
    esv2625456CNV Insertion19546169
    nsv2363CNV Insertion18451855
    esv268598CNV Insertion20981092
    nsv909946CNV Gain21882294

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    Disorders / Diseases
    for ZNF236 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus    		 OMIM gene information: 604760    OMIM disorders: --


    Find genes that share disorders with ZNF236           About GenesLikeMe

    Genetic Association Database (GAD): ZNF236
    Human Genome Epidemiology (HuGE) Navigator: ZNF236 (2 documents)

    Export disorders for ZNF236 gene to outside databases

    Publications
    for ZNF236 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for ZNF236 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with ZNF236)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of ZNF236, a glucose-regulated kruppel- like zinc-finger gene mapping to human chromosome 18q22-q23. (PubMed id 10458916)1, 2, 3 Holmes D.I.... Mason R.M. (Genomics 1999)
    2. Genetic analysis of diabetic nephropathy on chromosome 18 in African Americans: linkage analysis and dense SNP mapping. (PubMed id 19690890)1, 4 McDonough C.W....Bowden D.W. (Hum. Genet. 2009)
    3. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)
    4. Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. (PubMed id 23648065)1 Low S.K....Nakamura Y. (Cancer Sci. 2013)
    5. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    6. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    7. DNA sequence and analysis of human chromosome 18. (PubMed id 16177791)2 Nusbaum C.... Lander E.S. (Nature 2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. The Kruppel-like zinc-finger gene ZNF236 is alternatively spliced and excluded as susceptibility gene for diabetic nephropathy. (PubMed id 12906866)1 Halama N....van der Woude F.J. (Genomics 2003)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    External Searches for ZNF236 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
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    Genome Databases showing ZNF236 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7776 HGNC: 13028 AceView: ZNF236 Ensembl:ENSG00000130856 euGenes: HUgn7776
    ECgene: ZNF236 H-InvDB: ZNF236

    Other Databases showing ZNF236 gene

    (According to HUGE)
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    Specialized Databases showing ZNF236 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF236 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ZNF236 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    TryGeneCards Plus    		Patent Information for ZNF236 gene:
    Search GeneIP for patents involving ZNF236

    GeneCards and IP:
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