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ZNF236 Gene(Protein Coding)

Zinc Finger Protein 236

GCID:
GC18P076822
GIFtS:
46
Genes Participants
UDN Logo

Aliases for ZNF236 Gene

Aliases for ZNF236 Gene

  • Zinc Finger Protein 236 2 3 5
  • Regulated By Glucose 3
  • ZNF236A 3
  • ZNF236B 3

External Ids for ZNF236 Gene

Previous GeneCards Identifiers for ZNF236 Gene

  • GC18P074159
  • GC18P074689
  • GC18P074299
  • GC18P072663
  • GC18P074536
  • GC18P071217

Summaries for ZNF236 Gene

GeneCards Summary for ZNF236 Gene

ZNF236 (Zinc Finger Protein 236) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZFAT.

UniProtKB/Swiss-Prot for ZNF236 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF236 Gene

Genomics for ZNF236 Gene

Products:

  1. Regulatory Element

Regulatory Elements for ZNF236 Gene

Enhancers for ZNF236 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF236 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF236 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF236 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF236 Gene

Chromosome:
18
Start:
76,822,561 bp from pter
End:
76,970,732 bp from pter
Size:
148,172 bases
Orientation:
Plus strand

Genomic View for ZNF236 Gene

Genes around ZNF236 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF236 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF236 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ZNF236 Gene

Proteins for ZNF236 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for ZNF236 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UL36-ZN236_HUMAN
    Recommended name:
    Zinc finger protein 236
    Protein Accession:
    Q9UL36
    Secondary Accessions:
    • B2RTX9
    • Q9UL37

    Protein attributes for ZNF236 Gene

    Size:
    1845 amino acids
    Molecular mass:
    203704 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF236 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF236 Gene

Proteomics data for ZNF236 Gene at MOPED

Protein Expression for ZNF236 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ZNF236 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF236 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF236 Gene

Domains & Families for ZNF236 Gene

Gene Families for ZNF236 Gene

HGNC:

Protein Domains for ZNF236 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF236 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UL36

UniProtKB/Swiss-Prot:

ZN236_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 30 C2H2-type zinc fingers.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 30 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF236: view

Function for ZNF236 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for ZNF236 Gene

GENATLAS Biochemistry:
zinc finger protein 236,(glucose regulated Kruppel-like),ubiquitously expressed
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes for ZNF236 Gene

GenomeRNAi human phenotypes for ZNF236:
genes like me logo Genes that share phenotypes with ZNF236: view

Animal Model Products

CRISPR Products

miRNA for ZNF236 Gene

miRTarBase miRNAs that target ZNF236

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF236 Gene

Localization for ZNF236 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF236 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF236 Gene COMPARTMENTS Subcellular localization image for ZNF236 gene
Compartment Confidence
nucleus 5
cytosol 3

No data available for Gene Ontology (GO) - Cellular Components for ZNF236 Gene

Pathways & Interactions for ZNF236 Gene

SuperPathways for ZNF236 Gene

PathCards logoMore details on SuperPathways for ZNF236
No Data Available

Interacting Proteins for ZNF236 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000253159%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000264705%0d%0a9606.ENSP00000455507%0d%0a9606.ENSP00000276072%0d%0a9606.ENSP00000418379%0d%0a
Selected Interacting proteins: ENSP00000253159 for ZNF236 Gene via STRING

Gene Ontology (GO) - Biological Process for ZNF236 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF236: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF236 Gene

Drugs & Compounds for ZNF236 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for ZNF236 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for ZNF236 Gene

(10) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(66) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF236 Gene

Zinc finger protein 236:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF236 Gene

No ASD Table

Relevant External Links for ZNF236 Gene

GeneLoc Exon Structure for
ZNF236
ECgene alternative splicing isoforms for
ZNF236

Expression for ZNF236 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for ZNF236 Gene

mRNA expression in normal human tissues for ZNF236 Gene
mRNA expression by BioGPS for ZNF236 GenemRNA expression by GTEx for ZNF236 Gene

Protein differential expression in normal tissues from HIPED for ZNF236 Gene

This gene is overexpressed in Frontal cortex (57.9) and Kidney (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF236 Gene



SOURCE GeneReport for Unigene cluster for ZNF236 Gene Hs.719137

mRNA Expression by UniProt/SwissProt for ZNF236 Gene

Q9UL36-ZN236_HUMAN
Tissue specificity: Ubiquitous. Expression levels are highest in skeletal muscle and brain, intermediate in heart, pancreas, and placenta, and lowest in kidney, liver, and lung.
genes like me logo Genes that share expression patterns with ZNF236: view

Protein tissue co-expression partners for ZNF236 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZNF236 Gene

Orthologs for ZNF236 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZNF236 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia ZNF236 35
  • 79.92 (n)
  • 81.57 (a)
ZNF236 36
  • 86 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia ZNF236 35
  • 86.71 (n)
  • 90.86 (a)
-- 36
  • 17 (a)
 ManyToMany
mouse
(Mus musculus)
 Mammalia Zfp236 35
  • 83.39 (n)
  • 88.66 (a)
Zfp236 16
Zfp236 36
  • 88 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia ZNF236 35
  • 99.29 (n)
  • 99.67 (a)
ZNF236 36
  • 100 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Zfp236 35
  • 83.79 (n)
  • 88.51 (a)
oppossum
(Monodelphis domestica)
 Mammalia ZNF236 36
  • 82 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia ZNF236 36
  • 80 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves ZNF236 35
  • 74.84 (n)
  • 84.02 (a)
ZNF236 36
  • 80 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia ZNF236 36
  • 78 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia Str.17000 35
znf236 35
  • 70.44 (n)
  • 73.8 (a)
African clawed frog
(Xenopus laevis)
 Amphibia Xl.5283 35
zebrafish
(Danio rerio)
 Actinopterygii znf236 36
  • 56 (a)
 OneToOne
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes FZF1 36
  • 23 (a)
 OneToMany
Species with no ortholog for ZNF236:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF236 Gene

ENSEMBL:
Gene Tree for ZNF236 (if available)
TreeFam:
Gene Tree for ZNF236 (if available)

Paralogs for ZNF236 Gene

Paralogs for ZNF236 Gene

(98) SIMAP similar genes for ZNF236 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF236: view

Variants for ZNF236 Gene

Sequence variations from dbSNP and Humsavar for ZNF236 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs2276211 - 76,868,824(-) GCTCC(A/G)AGGAG reference, missense
rs8093707 - 76,899,174(+) ATGTT(C/G/T)CAGTC reference, missense
rs3794873 - 76,904,418(-) ATAGC(C/T)TTGGA reference, missense
rs3752078 - 76,908,480(-) CATGG(C/T)CTCGG reference, missense
rs608433 - 76,899,171(-) TGGAA(C/T)ATTCG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ZNF236 Gene

Variant ID Type Subtype PubMed ID
esv2717388 CNV Deletion 23290073
esv268598 CNV Insertion 20981092
nsv909946 CNV Gain 21882294
esv2717421 CNV Deletion 23290073
esv2547601 CNV Insertion 19546169
esv2717422 CNV Deletion 23290073
nsv2363 CNV Insertion 18451855
esv2625456 CNV Insertion 19546169
esv2588513 CNV Deletion 19546169
esv2717423 CNV Deletion 23290073

Variation tolerance for ZNF236 Gene

Residual Variation Intolerance Score: 1.31% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.02; 68.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF236 Gene

Human Gene Mutation Database (HGMD)
ZNF236

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF236 Gene

Disorders for ZNF236 Gene

Relevant External Links for ZNF236

Genetic Association Database (GAD)
ZNF236
Human Genome Epidemiology (HuGE) Navigator
ZNF236
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF236

No disorders were found for ZNF236 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF236 Gene

Publications for ZNF236 Gene

  1. Cloning and characterization of ZNF236, a glucose-regulated kruppel- like zinc-finger gene mapping to human chromosome 18q22-q23. (PMID: 10458916) Holmes D.I. … Mason R.M. (Genomics 1999) 2 3 4 67
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  3. Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. (PMID: 23648065) Low S.K. … Nakamura Y. (Cancer Sci. 2013) 3
  4. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3
  5. Genetic analysis of diabetic nephropathy on chromosome 18 in African Americans: linkage analysis and dense SNP mapping. (PMID: 19690890) McDonough C.W. … Bowden D.W. (Hum. Genet. 2009) 3

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Sources for ZNF236 Gene

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