ZNF236 Gene

Aliases
for ZNF236 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC18P074159 GC18P074689 GC18P074299 GC18P072663 GC18P071217

Summaries
for ZNF236 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for ZNF236 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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SwitchGear Promoter luciferase reporter plasmid: ZNF236 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF236

ZNF236 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P074536:  view genomic region     (about GC identifiers)

Proteins
for ZNF236 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for ZNF236: NX_Q9UL36

Explore proteomics data for ZNF236 at MOPED

Post-translational modifications: 

ZNF236 Human Recombinant Protein Products:

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	antibodies-online peptides for ZNF236

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	antibodies-online antibodies for ZNF236 (4 products)

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Domains /
Families
for ZNF236 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q9UL36

Find genes that share domains with ZNF236           About GenesLikeMe

Function
for ZNF236 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 4 molecular function terms:    About this table

genOway: Develop your customized and physiologically relevant rodent model for ZNF236

miRNA Products:		miRTarBase miRNAs that target ZNF236: hsa-mir-155-5p (MIRT005091), hsa-let-7e-5p (MIRT051497), hsa-mir-128-3p (MIRT021965), hsa-mir-132-3p (MIRT021847), hsa-mir-142-3p (MIRT021570)
		Block miRNA regulation of human, mouse, rat ZNF236 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate ZNF236 (see all 87):
		hsa-miR-520e hsa-miR-300 hsa-miR-106a hsa-miR-374a hsa-miR-519a hsa-miR-4275 hsa-miR-3142 hsa-miR-93
		SwitchGear 3'UTR luciferase reporter plasmid: ZNF236 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for ZNF236
		Predesigned siRNA for gene silencing in human, mouse, rat ZNF236

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for ZNF236

Clone Products:		OriGene clones in human, mouse for ZNF236 (see all 5) OriGene ORF clones in mouse, rat for ZNF236 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ZNF236 (NM_007345)
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZNF236
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF236

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ZNF236
		Browse ESI BIO Cell Lines and PureStem Progenitors for ZNF236

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF236

Localization
for ZNF236 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
nucleus	5
cytosol	2

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Gene Ontology (GO): 1 cellular component term:    About this table

Pathways & Interactions
for ZNF236 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Gene Ontology (GO): 3 biological process terms:    About this table

Drugs & Compounds
for ZNF236 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for ZNF236 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for ZNF236 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ZNF236 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TATAACCAGG

About this image

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for ZNF236
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZNF236
		QuantiTect SYBR Green Assays in human, mouse, rat ZNF236
		QuantiFast Probe-based Assays in human, mouse, rat ZNF236

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF236

Orthologs
for ZNF236 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for ZNF236 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for ZNF236 gene

SALL3²  SALL2²  SALL1²  SALL4²  

Selected SIMAP similar genes for ZNF236 using alignment to 3 protein entries:     ZN236_HUMAN (see all proteins) (see all similar genes):

ZNF826P    kr-znf3    ZNF808    ZFS-4    ZNF55    ZNF78L1

ZFS-5    HZF16    ZNF    DKFZp686N0199    DKFZp434J0650    ZNF468

ZFS-6    ZNF430    ZFS-2    ZNF785    ZNF22    ZNF737

Find genes that share paralogs with ZNF236           About GenesLikeMe

Genomic Variants
for ZNF236 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ZNF236 (see all 3305)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 18 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1162228381,2	C,F	--	71215955(+)	CCCTCC/TGAGCC	1	--	us2k1		2		WA EA	238
rs105813681,2	C	--	71277018(+)	ttttt-/T/T       T/TTTAAGTG	1	--	int1 trp3		1		NA	2
rs2005918841,2	C	--	74536323(+)	GCCTTT/CGTGGG	2	/R /C	mis1		1		EU	1323
rs1505695341,2	C	--	74536358(+)	CATGAC/TCCAGG	2	D	syn1		0	--	--	--	--
rs1911215281,2		--	74536542(+)	GTGCAA/GTGTCT	1	--	int1		0	--	--	--	--
rs1395609951,2	C	--	74536550(+)	TCTCAG/TTTACT	1	--	int1		0	--	--	--	--
rs766541231,2	C	--	74536593(+)	AAATTC/TCCACG	1	--	int1		0	--	--	--	--
rs116596891,2	H	--	74536721(+)	ACTTCA/CTAATT	1	--	int1		0	--	--	--	--
rs1500201771,2		--	74536814(+)	TCCCTC/TTCCGG	1	--	int1		0	--	--	--	--
rs739682151,2	C,F	--	74536839(+)	GGAGCC/TCCCTT	1	--	int1		2		WA	120

HapMap Linkage Disequilibrium report for ZNF236 (74534563 - 74682683 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10 variations for ZNF236:    About this table    

Variant ID	Type	Subtype	PubMed ID
esv2717388	CNV	Deletion	23290073
esv2588513	CNV	Deletion	19546169
esv2717423	CNV	Deletion	23290073
esv2717421	CNV	Deletion	23290073
esv2717422	CNV	Deletion	23290073
esv2547601	CNV	Insertion	19546169
esv2625456	CNV	Insertion	19546169
nsv2363	CNV	Insertion	18451855
esv268598	CNV	Insertion	20981092
nsv909946	CNV	Gain	21882294

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing ZNF236

DNA2.0 Custom Variant and Variant Library Synthesis for ZNF236

Disorders / Diseases
for ZNF236 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for ZNF236 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. Cloning and characterization of ZNF236, a glucose-regulated kruppel- like zinc-finger gene mapping to human chromosome 18q22-q23. (PubMed id 10458916)^{1, 2, 3} Holmes D.I.... Mason R.M. (Genomics 1999)
2. Genetic analysis of diabetic nephropathy on chromosome 18 in African Americans: linkage analysis and dense SNP mapping. (PubMed id 19690890)^{1, 4} McDonough C.W....Bowden D.W. (Hum. Genet. 2009)
3. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)^{1, 4} Trynka G....Wijmenga C. (Gut 2009)
4. Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. (PubMed id 23648065)¹ Low S.K....Nakamura Y. (Cancer Sci. 2013)
5. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (amp 2012)
6. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (amp 2008)
7. DNA sequence and analysis of human chromosome 18. (PubMed id 16177791)² Nusbaum C.... Lander E.S. (Nature 2005)
8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S.... Malek J. (Genome Res. 2004)
9. The Kruppel-like zinc-finger gene ZNF236 is alternatively spliced and excluded as susceptibility gene for diabetic nephropathy. (PubMed id 12906866)¹ Halama N....van der Woude F.J. (Genomics 2003)
10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

External Searches for ZNF236 gene

Genome Databases showing ZNF236 gene

Other Databases showing ZNF236 gene

Specialized Databases showing ZNF236 gene

Products
for ZNF236 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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