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Aliases for ZNF236 Gene

Aliases for ZNF236 Gene

  • Zinc Finger Protein 236 2 3 5
  • Regulated By Glucose 3
  • ZNF236A 3
  • ZNF236B 3

External Ids for ZNF236 Gene

Previous GeneCards Identifiers for ZNF236 Gene

  • GC18P074159
  • GC18P074689
  • GC18P074299
  • GC18P072663
  • GC18P074536
  • GC18P071217

Summaries for ZNF236 Gene

GeneCards Summary for ZNF236 Gene

ZNF236 (Zinc Finger Protein 236) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZFAT.

UniProtKB/Swiss-Prot for ZNF236 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF236 Gene

Genomics for ZNF236 Gene

Regulatory Elements for ZNF236 Gene

Enhancers for ZNF236 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18F076820 1 ENCODE 11.4 0.0 -17 5.1 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF48 ZNF2 YY1 ZNF121 RNU6-346P ZNF236 LOC100131655
GH18F076795 0.2 ENCODE 6.4 -26.4 -26362 1.3 ARID1B RFX1 GATA2 NCOR1 TAL1 FOXJ2 ZNF236 RNU6-346P ENSG00000265626
GH18F076943 0.7 ENCODE 6.4 +121.5 121533 1.1 GATA3 POLR2A SMARCA4 CEBPB ZNF236 LOC105372217 LOC100421894
GH18F076952 0.4 ENCODE 6.3 +130.6 130633 1.8 CEBPB CEBPG RAD21 NR2F2 RARA YY1 ATF3 ZBTB33 NR2F6 ZNF236 LOC105372217 LOC100421894
GH18F076958 0.2 ENCODE 6.3 +136.5 136469 1.2 BHLHE40 ZNF236 LOC105372217 LOC100421894
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZNF236 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF236 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000114544 -61 3801 HDGF ARID4B SIN3A DMAP1 ZNF48 ZNF2 YY1 ZNF121 ELK1 ZNF143

Genomic Location for ZNF236 Gene

Chromosome:
18
Start:
76,822,561 bp from pter
End:
76,970,732 bp from pter
Size:
148,172 bases
Orientation:
Plus strand

Genomic View for ZNF236 Gene

Genes around ZNF236 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF236 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF236 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF236 Gene

Proteins for ZNF236 Gene

  • Protein details for ZNF236 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UL36-ZN236_HUMAN
    Recommended name:
    Zinc finger protein 236
    Protein Accession:
    Q9UL36
    Secondary Accessions:
    • B2RTX9
    • Q9UL37

    Protein attributes for ZNF236 Gene

    Size:
    1845 amino acids
    Molecular mass:
    203704 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF236 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF236 Gene

Post-translational modifications for ZNF236 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF236 Gene

Domains & Families for ZNF236 Gene

Gene Families for ZNF236 Gene

Protein Domains for ZNF236 Gene

Suggested Antigen Peptide Sequences for ZNF236 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UL36

UniProtKB/Swiss-Prot:

ZN236_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 30 C2H2-type zinc fingers.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 30 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF236: view

Function for ZNF236 Gene

Molecular function for ZNF236 Gene

GENATLAS Biochemistry:
zinc finger protein 236,(glucose regulated Kruppel-like),ubiquitously expressed
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF236 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF236: view
genes like me logo Genes that share phenotypes with ZNF236: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF236 Gene

Localization for ZNF236 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF236 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF236 Gene COMPARTMENTS Subcellular localization image for ZNF236 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for ZNF236 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF236: view

Pathways & Interactions for ZNF236 Gene

SuperPathways for ZNF236 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF236 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0071333 cellular response to glucose stimulus IEP 9299475
genes like me logo Genes that share ontologies with ZNF236: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF236 Gene

Transcripts for ZNF236 Gene

Unigene Clusters for ZNF236 Gene

Zinc finger protein 236:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF236 Gene

No ASD Table

Relevant External Links for ZNF236 Gene

GeneLoc Exon Structure for
ZNF236
ECgene alternative splicing isoforms for
ZNF236

Expression for ZNF236 Gene

mRNA expression in normal human tissues for ZNF236 Gene

Protein differential expression in normal tissues from HIPED for ZNF236 Gene

This gene is overexpressed in Frontal cortex (57.9) and Kidney (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF236 Gene



Protein tissue co-expression partners for ZNF236 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF236 Gene:

ZNF236

SOURCE GeneReport for Unigene cluster for ZNF236 Gene:

Hs.719137

mRNA Expression by UniProt/SwissProt for ZNF236 Gene:

Q9UL36-ZN236_HUMAN
Tissue specificity: Ubiquitous. Expression levels are highest in skeletal muscle and brain, intermediate in heart, pancreas, and placenta, and lowest in kidney, liver, and lung.
genes like me logo Genes that share expression patterns with ZNF236: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZNF236 Gene

Orthologs for ZNF236 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZNF236 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF236 34 35
  • 99.29 (n)
dog
(Canis familiaris)
Mammalia ZNF236 34
  • 86.71 (n)
-- 35
  • 17 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Zfp236 34
  • 83.79 (n)
mouse
(Mus musculus)
Mammalia Zfp236 34 16 35
  • 83.39 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF236 35
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF236 35
  • 80 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF236 34 35
  • 79.92 (n)
chicken
(Gallus gallus)
Aves ZNF236 34 35
  • 74.84 (n)
lizard
(Anolis carolinensis)
Reptilia ZNF236 35
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znf236 34
  • 70.44 (n)
Str.17000 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.5283 34
zebrafish
(Danio rerio)
Actinopterygii znf236 35
  • 56 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FZF1 35
  • 23 (a)
OneToMany
Species where no ortholog for ZNF236 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF236 Gene

ENSEMBL:
Gene Tree for ZNF236 (if available)
TreeFam:
Gene Tree for ZNF236 (if available)

Paralogs for ZNF236 Gene

Paralogs for ZNF236 Gene

genes like me logo Genes that share paralogs with ZNF236: view

Variants for ZNF236 Gene

Sequence variations from dbSNP and Humsavar for ZNF236 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs10164090 -- 76,931,615(+) CTGAC(A/C)CCAGC intron-variant
rs1044088 -- 76,970,258(+) CAGGA(C/T)ATCTC utr-variant-3-prime
rs10451402 -- 76,938,274(+) agtac(C/T)aggta intron-variant
rs10469070 -- 76,941,437(+) CGCCA(C/T)GTGGA intron-variant
rs10469071 -- 76,941,648(+) GAGCC(A/G)GGTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF236 Gene

Variant ID Type Subtype PubMed ID
dgv1644n106 CNV duplication 24896259
dgv1645n106 CNV deletion 24896259
dgv1932e59 CNV duplication 20981092
esv2547601 CNV insertion 19546169
esv2588513 CNV deletion 19546169
esv2625456 CNV insertion 19546169
esv2717388 CNV deletion 23290073
esv2717421 CNV deletion 23290073
esv2717422 CNV deletion 23290073
esv2717423 CNV deletion 23290073
esv3331506 CNV duplication 20981092
esv3345401 CNV duplication 20981092
esv3376995 CNV insertion 20981092
esv3447107 CNV duplication 20981092
esv3555703 CNV deletion 23714750
esv3643197 CNV loss 21293372
esv3643199 CNV loss 21293372
nsv1056690 CNV gain 25217958
nsv1063632 CNV gain 25217958
nsv1071865 CNV deletion 25765185
nsv1077850 CNV duplication 25765185
nsv1129606 CNV tandem duplication 24896259
nsv1129608 CNV tandem duplication 24896259
nsv1130687 CNV deletion 24896259
nsv1135059 CNV deletion 24896259
nsv1140142 CNV insertion 24896259
nsv1143794 CNV deletion 24896259
nsv1146345 CNV duplication 26484159
nsv1152371 CNV deletion 26484159
nsv2363 CNV insertion 18451855
nsv477637 CNV novel sequence insertion 20440878
nsv960288 CNV duplication 23825009

Variation tolerance for ZNF236 Gene

Residual Variation Intolerance Score: 1.31% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.02; 68.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF236 Gene

Human Gene Mutation Database (HGMD)
ZNF236
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF236

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF236 Gene

Disorders for ZNF236 Gene

Relevant External Links for ZNF236

Genetic Association Database (GAD)
ZNF236
Human Genome Epidemiology (HuGE) Navigator
ZNF236
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF236

No disorders were found for ZNF236 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF236 Gene

Publications for ZNF236 Gene

  1. Cloning and characterization of ZNF236, a glucose-regulated kruppel- like zinc-finger gene mapping to human chromosome 18q22-q23. (PMID: 10458916) Holmes D.I. … Mason R.M. (Genomics 1999) 2 3 4 64
  2. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 46 64
  3. Genetic analysis of diabetic nephropathy on chromosome 18 in African Americans: linkage analysis and dense SNP mapping. (PMID: 19690890) McDonough C.W. … Bowden D.W. (Hum. Genet. 2009) 3 46 64
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  5. Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. (PMID: 23648065) Low S.K. … Nakamura Y. (Cancer Sci. 2013) 3 64

Products for ZNF236 Gene

Sources for ZNF236 Gene

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