ZNF236 Gene
protein-coding GIFtS : 45
GCID: GC18 P074536
zinc finger protein 236
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Aliasesfor ZNF236 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Zinc Finger Protein 236 1 2 ZNF236A2 ZNF236B2 Regulated By Glucose2
Export aliases for ZNF236 gene to outside databases Previous GC identifers: GC18P074159 GC18P074689 GC18P074299 GC18P072663 GC18P071217
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Summariesfor ZNF236 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: ZN236_HUMAN, Q9UL36 Function : May be involved in transcriptional regulation
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Genomic Viewsfor ZNF236 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000018.9 NC_018929.1 NT_025028.14 Regulatory elements: Search SABiosciences Regulatory transcription factor binding sites for ZNF236 Other transcription factors Search SABiosciences Chromatin IP Primers for ZNF236 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat ZNF236
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 18q22-q23 Ensembl cytogenetic band: 18q23 HGNC cytogenetic band: 18q22-q23 ZNF236 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 18 GeneLoc Exon Structure
GeneLoc location for GC18P074536: view genomic region
(about GC identifiers )
Start:
74,534,563 bp from pter
End:
74,682,683 bp from pter
Size:
148,121 bases
Orientation:
plus strand
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Proteinsfor ZNF236 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: ZN236_HUMAN, Q9UL36 (See
protein sequence )Recommended Name: Zinc finger protein 236 Size : 1845 amino acids; 203704 Da
Subcellular location : Nucleus (Probable)
Secondary accessions : B2RTX9 Q9UL37Alternative splicing : 2 isoforms : Q9UL36-1 Q9UL36-2 (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)Explore the universe of human proteins at neXtProt for ZNF236: NX_Q9UL36 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9UL36 ZNF236 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_031371.3 ENSEMBL proteins: ENSP00000322361 ENSP00000444524 ENSP00000253159 ENSP00000463787 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005634 nucleus
NAS --
ZNF236 for ontologies About GeneDecksing ZNF236 Antibody Products: Assay Products for ZNF236:
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Protein
Domains / Familiesfor ZNF236 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
ZNF236 for domains About GeneDecksing 3 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q9UL36 ProtoNet protein and cluster: Q9UL36
UniProtKB/Swiss-Prot: ZN236_HUMAN, Q9UL36 Similarity : Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity : Contains 30 C2H2-type zinc fingers
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Functionfor ZNF236 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: ZN236_HUMAN, Q9UL36 Function : May be involved in transcriptional regulation
Genatlas biochemistry entry for ZNF236 : zinc finger protein 236,(glucose regulated Kruppel-like),ubiquitously expressed Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ZNF236 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ZNF236OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ZNF236 (NM_007345 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF236 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ZNF236
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF236
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0003677 DNA binding
IEA -- GO:0003700 sequence-specific DNA binding transcription factor activity
NAS -- GO:0008270 zinc ion binding
IEA --
ZNF236 for ontologies About GeneDecksing
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Pathways & Interactionsfor ZNF236 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF236 Gene Ontology (GO): 3 biological process terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0006351 transcription, DNA-dependent
IEA -- GO:0006355 regulation of transcription, DNA-dependent
NAS -- GO:0071333 cellular response to glucose stimulus
IEP 9299475
ZNF236 for ontologies About GeneDecksing
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Drugs & Compoundsfor ZNF236 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for ZNF236 Search CenterWatch for drugs/clinical trials and news about ZNF236 / ZN236
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Transcriptsfor ZNF236 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for ZNF236 gene: NM_007345.3 Unigene Cluster for ZNF236:
Zinc finger protein 236 Hs.719137 [show with all ESTs ] Unigene Representative Sequence: NM_007345 8 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000320610 ENST00000543926 (uc002lmj.3 ) ENST00000253159 (uc002lmi.3 )ENST00000579322 (uc002lmk.1 ) ENST00000583095 ENST00000583488 ENST00000584565 ENST00000581450 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ZNF236 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ZNF236OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ZNF236 (NM_007345 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF236 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ZNF236
Additional cDNA sequence: AB208834.1 AF083213.1 AF085244.1 BC140859.1 BX648028.1
9 DOTS entries : DT.100812992 DT.209775
DT.95118448 DT.91950905 DT.92422923 DT.95266562 DT.91684551 DT.70101555 DT.97803070 24/66 AceView cDNA sequences (see all 66 ):
CR599803 AI783463 AF083213 AW192251 T23550 AW190658 BE466654 F10412 BX648028 F09223 AW241529 CD251873 AW629086 BE548450 AI989339 AF085244 NM_007345 BQ022213 BG287737 BP354765 AF085243 AI628104 BM460178 CD518356 GeneLoc Exon Structure
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Expression for ZNF236 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section ZNF236 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TATAACCAGG
About this image See ZNF236 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ZNF236 SOURCE GeneReport for Unigene cluster: Hs.719137 UniProtKB/Swiss-Prot: ZN236_HUMAN, Q9UL36 Tissue specificity : Ubiquitous. Expression levels are highest in skeletal muscle and brain, intermediate in heart,pancreas, and placenta, and lowest in kidney, liver, and lung SABiosciences Custom PCR Arrays for ZNF236 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ZNF236Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat ZNF236 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ZNF236 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ZNF236 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF236
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Orthologsfor ZNF236 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for ZNF236 gene from 5/15 species (see all 15 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
ZNF2361
zinc finger protein 236
74.88(n) 84.02(a)
 
421008 XM_419094.3 XP_419094.3
lizard (Anolis carolinensis)
Reptilia
----
--
79(a) 31(a)
1 ↔ 1possible ortholog
4(50803141-50837072) 4(50839365-50852051)
African clawed frog (Xenopus laevis)
Amphibia
Xl.52832
Xenopus laevis transcribed sequence with weak similarity more
75.39(n)
 
AW638487.1
zebrafish (Danio rerio)
Actinopterygii
znf2366
zinc finger protein 236
54(a)
1 ↔ 1
16(7964346-8014222)
honey bee (Apis mellifera)
Insecta
--
--
25(a)
1 ↔ 1
Group11.1(75173-79973)
ENSEMBL Gene Tree for ZNF236 (if available)TreeFam Gene Tree for ZNF236 (if available)
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Paralogsfor ZNF236 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for ZNF236 gene SALL3 2 SALL2 2 SALL1 2 SALL4 2 18/112 SIMAP similar genes for ZNF236 using alignment to 3 protein entries: ZN236_HUMAN (see all proteins )
(see all similar genes ):ZNF826P kr-znf3 ZNF808 ZFS-4 ZNF55 ZNF78L1 ZFS-5 HZF16 ZNF DKFZp686N0199 DKFZp434J0650 ZNF468 ZFS-6 ZFS-2 ZNF785 ZNF22 ZNFN1A2 ZNF263
ZNF236 for paralogs About GeneDecksing
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Genomic Variantsfor ZNF236 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 18 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for ZNF236 (74534563 - 74682683 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 6 variations for ZNF236 3 CNVs : 88947 88945 77952 3 Indels : 102723 88946 102724
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ZNF236
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Disorders
/ Diseasesfor ZNF236 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
ZNF236 for disorders About GeneDecksing
OMIM gene information: 604760
OMIM disorders : --1 disease for ZNF236 : About MalaCards nephropathy Human Genome Epidemiology (HuGE) Navigator: ZNF236 (2 documents) Export disorders for ZNF236 gene to outside databases
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Publicationsfor ZNF236 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for ZNF236 gene integrated from 9 sources : (articles sorted by number of sources associating them with ZNF236) Utopia : connect your pdf to the dynamic world of online information
Cloning and characterization of ZNF236, a glucose-regulated kruppel- like zinc-finger gene mapping to human chromosome 18q22-q23. (PubMed id 10458916) 1 , 2 , 3 Holmes D.I.... Mason R.M. (1999) Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724) 1 Udeshi N.D....Carr S.A. (2012) Genetic analysis of diabetic nephropathy on chromosom e 18 in African Americans: linkage analysis and dense SNP mapping. (PubMed id 19690890) 1 McDonough C.W....Bowden D.W. (2009) Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061) 1 Trynka G....Wijmenga C. (2009) Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348) 1 Barbe L....Andersson-Svahn H. (2008) DNA sequence and analysis of human chromosome 18. (PubMed id 16177791) 2 Nusbaum C.... Lander E.S. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) The Kruppel-like zinc-finger gene ZNF236 is alternatively spliced and excluded as susceptibility gene for diabetic nephropathy. (PubMed id 12906866) 1 Halama N....van der Woude F.J. (2003) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Identification of glucose-regulated genes in human mesangial cells by mRNA differential display. (PubMed id 9299475) 1 Holmes D.I.... Mason R.M. (1997)
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External Searches for ZNF236 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing ZNF236 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing ZNF236 gene
(According to HUGE )
About This Section --
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Specialized Databases showing ZNF236 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for ZNF236 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for ZNF236 gene: Search GeneIP for patents involving ZNF236 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor ZNF236 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for ZNF236 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for ZNF236 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ZNF236 Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for ZNF236 OriGene 3'-UTR Clone for ZNF236 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ZNF236 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ZNF236 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for ZNF236 OriGene Custom Protein Services for ZNF236 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF236 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ZNF236 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat ZNF236 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat ZNF236 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ZNF236 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ZNF236
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ZNF236 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF236
Search ThermoFisher Antibodies for ZNF236
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ZNF236
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Aliases for ZNF236
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Expression for ZNF236
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