Aliases for ZNF236 Gene
External Ids for ZNF236 Gene
- HGNC: 13028
- Entrez Gene: 7776
- Ensembl: ENSG00000130856
- OMIM: 604760
- UniProtKB: Q9UL36
Previous GeneCards Identifiers for ZNF236 Gene
- GC18P074159
- GC18P074689
- GC18P074299
- GC18P072663
- GC18P074536
- GC18P071217
Summaries for ZNF236 Gene
GeneCards Summary for ZNF236 Gene
ZNF236 (Zinc Finger Protein 236) is a Protein Coding gene. Diseases associated with ZNF236 include Type 1 Diabetes Mellitus 6. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZFAT.
UniProtKB/Swiss-Prot for ZNF236 Gene
-
May be involved in transcriptional regulation.
Additional gene information for ZNF236 Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF236 Gene
Genomics for ZNF236 Gene
GeneHancer (GH) Regulatory Elements for ZNF236 Gene
Promoters and enhancers for ZNF236 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around ZNF236 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for ZNF236 Gene
Genomic Locations for ZNF236 Gene
- chr18:76,822,561-76,970,732
- (GRCh38/hg38)
- Size:
- 148,172 bases
- Orientation:
- Plus strand
- chr18:74,534,563-74,682,683
- (GRCh37/hg19)
Genomic View for ZNF236 Gene
Genes around ZNF236 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 18q23 by Ensembl
- 18q23 by Entrez Gene
- 18q22-q23 by HGNC
ZNF236 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ZNF236 Gene
Proteins for ZNF236 Gene
-
Protein details for ZNF236 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UL36-ZN236_HUMAN
- Recommended name:
- Zinc finger protein 236
- Protein Accession:
- Q9UL36
- B2RTX9
- Q9UL37
Protein attributes for ZNF236 Gene
- Size:
- 1845 amino acids
- Molecular mass:
- 203704 Da
- Quaternary structure:
- No Data Available
Protein Expression for ZNF236 Gene
Post-translational modifications for ZNF236 Gene
No Post-translational modifications
Other Protein References for ZNF236 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for ZNF236
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Protein Products
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Assay Products
No data available for DME Specific Peptides for ZNF236 Gene
Domains & Families for ZNF236 Gene
Gene Families for ZNF236 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
- Transcription factors
Protein Domains for ZNF236 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ZNF236 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9UL36- Family:
-
- Belongs to the krueppel C2H2-type zinc-finger protein family.
Function for ZNF236 Gene
Molecular function for ZNF236 Gene
- GENATLAS Biochemistry:
- zinc finger protein 236,(glucose regulated Kruppel-like),ubiquitously expressed
- UniProtKB/Swiss-Prot Function:
- May be involved in transcriptional regulation.
Phenotypes From GWAS Catalog for ZNF236 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for ZNF236 Gene
- GenomeRNAi human phenotypes for ZNF236:
Animal Model Products
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-
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CRISPR Products
-
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-
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miRNA for ZNF236 Gene
- miRTarBase miRNAs that target ZNF236
-
- hsa-mir-155-5p (MIRT005091)
- hsa-mir-142-3p (MIRT021570)
- hsa-mir-132-3p (MIRT021847)
- hsa-mir-128-3p (MIRT021965)
- hsa-let-7e-5p (MIRT051497)
- hsa-mir-4732-5p (MIRT450522)
- hsa-mir-4668-5p (MIRT450523)
- hsa-mir-3148 (MIRT450524)
- hsa-mir-6783-5p (MIRT450525)
- hsa-mir-548n (MIRT450526)
- hsa-mir-6872-3p (MIRT719764)
- hsa-mir-670-3p (MIRT719765)
- hsa-mir-6836-3p (MIRT719766)
- hsa-mir-7162-5p (MIRT719767)
- hsa-mir-516b-3p (MIRT719768)
- hsa-mir-516a-3p (MIRT719769)
- hsa-mir-2115-5p (MIRT719770)
- hsa-mir-222-3p (MIRT719771)
- hsa-mir-221-3p (MIRT719772)
- hsa-mir-6829-3p (MIRT719773)
- hsa-mir-6791-3p (MIRT719774)
- hsa-mir-6778-3p (MIRT719775)
- hsa-mir-1976 (MIRT719776)
- hsa-mir-4797-3p (MIRT719777)
- hsa-mir-6893-3p (MIRT719778)
- hsa-mir-370-3p (MIRT719779)
- hsa-mir-660-3p (MIRT719780)
miRNA Products
- Search ViGene Biosciences for ZNF236
Inhibitory RNA Products
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Clone Products
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-
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Cell Line Products
-
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF236 Gene
Localization for ZNF236 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ZNF236 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 3 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF236 Gene
Pathways & Interactions for ZNF236 Gene
No Data Available
Interacting Proteins for ZNF236 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0071333 | cellular response to glucose stimulus | IEP | 9299475 |
No data available for Pathways by source and SIGNOR curated interactions for ZNF236 Gene
Transcripts for ZNF236 Gene
mRNA/cDNA for ZNF236 Gene
- (7) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (66) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ZNF236 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ZNF236
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZNF236
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miRNA Products
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Inhibitory RNA Products
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-
ViGene Biosciences ready-to-package AAV shRNAs for ZNF236 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- genomics-online: cdna clones - Search results for available ZNF236 gene related products
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- Applied Biological Materials Clones for ZNF236
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for ZNF236 Gene
This gene is overexpressed in Frontal cortex (57.9) and Kidney (9.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF236 Gene
NURSA nuclear receptor signaling pathways regulating expression of ZNF236 Gene:
ZNF236SOURCE GeneReport for Unigene cluster for ZNF236 Gene:
Hs.719137mRNA Expression by UniProt/SwissProt for ZNF236 Gene:
Q9UL36-ZN236_HUMAN
Tissue specificity:
Ubiquitous. Expression levels are highest in skeletal muscle and brain, intermediate in heart, pancreas, and placenta, and lowest in kidney, liver, and lung.
Evidence on tissue expression from TISSUES for ZNF236 Gene
- Kidney(4.1)
Primer Products
-
OriGene qPCR primer pairs for ZNF236
- genomics-online: primer clones - Search results for available ZNF236 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF236 Gene
Orthologs for ZNF236 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ZNF236 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | ZNF236 33 |
|
||
| -- 34 |
|
ManyToMany | |||
| rat (Rattus norvegicus) |
Mammalia | Zfp236 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Zfp236 33 16 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ZNF236 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | ZNF236 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | ZNF236 33 34 |
|
||
| chicken (Gallus gallus) |
Aves | ZNF236 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | ZNF236 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | znf236 33 |
|
||
| Str.17000 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.5283 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | znf236 34 |
|
OneToOne | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | FZF1 34 |
|
OneToMany |
- Species where no ortholog for ZNF236 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for ZNF236 Gene
(98) SIMAP similar genes for ZNF236 Gene using alignment to 3 proteins:
- ZNF826P
- kr-znf3
- ZNF808
- ZNF78L1
- ZNF55
- ZFS-4
- ZFS-5
- HZF16
- ZNF
- DKFZp686N0199
- ZNF468
- DKFZp434J0650
- ZNF430
- ZFS-6
- ZNF785
- ZFS-2
- ZNF22
- ZNF737
- ZNFN1A2
- ZNF263
- KLF1
- ZNF516
- ZNF72
- ZFX
- ZNF410
- ZNF702P
- ZNF219
- KLF4
- KLF13
- BCL6B
- DKFZp547H249
- ZNF818P
- RREB1
- ZNF600
- A-328A3.4
- ZNF696
- ZNF692
- ZNF844
- ZNF585A
- ZKSCAN1
- ZNF697
- ZNF521
- DKFZp686O1631
- ZNF770
- PLZF
- ZNF25
- ZNF146
- ZFP64
- DKFZp666C237
- MAZ
- GTF3A
- GZF1
- ZNF79
- ZNF672
- ZNF558
- ZNF154
- ZFP1
- WT1
- ZNF883
- ZNF391
- ZNF286A
- ZNF35
- ZNF83
- ZNF557
- ZSCAN31
- ZNF773
- ZNF684
- ZNF664
- ZNF581
- ZNF570
- ZNF564
- ZNF56
- ZNF449
- ZNF436
- ZNF324
- ZNF323
- PLAGL1
- DKFZp434G1930
- DKFZp313M0722
- ZFP41
- DKFZp686G16228
- ZNF485
- smap-7
- ZNF578
- ZSCAN21
- ZNF586
- ZNF547
- ZNF708
- ZNF2
- ZNF137P
- REST
- OVOL1
- Nbla00121
- HZF41
- HZF40
- HZF30
- DKFZp686O111
- DKFZp686D2168
Variants for ZNF236 Gene
| SNP ID | Clin | Chr 18 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000048008 | -- | 76,862,900(+) | A/G | intron_variant | |
| rs1000054036 | -- | 76,958,673(+) | T/C | genic_downstream_transcript_variant, intron_variant | |
| rs1000060421 | -- | 76,936,476(+) | T/C | genic_downstream_transcript_variant, intron_variant | |
| rs1000078624 | -- | 76,862,699(+) | A/G | intron_variant | |
| rs1000121419 | -- | 76,949,701(+) | C/A | genic_downstream_transcript_variant, intron_variant |
Residual Variation Intolerance Score:
1.31% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.02;
68.49% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ZNF236 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF236 Gene
Disorders for ZNF236 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| type 1 diabetes mellitus 6 |
|
|
Search ZNF236 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ZNF236
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF236 Gene
Publications for ZNF236 Gene
- Cloning and characterization of ZNF236, a glucose-regulated Kruppel-like zinc-finger gene mapping to human chromosome 18q22-q23. (PMID: 10458916) Holmes DI … Mason RM (Genomics 1999) 2 3 4 58
- Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 44 58
- Genetic analysis of diabetic nephropathy on chromosome 18 in African Americans: linkage analysis and dense SNP mapping. (PMID: 19690890) McDonough CW … Bowden DW (Human genetics 2009) 3 44 58
- A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58
- Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. (PMID: 23648065) Low SK … Nakamura Y (Cancer science 2013) 3 58
Products for ZNF236 Gene
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Sources for ZNF236 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew