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ZNF236 Gene(Protein Coding)

Zinc Finger Protein 236

GCID:
GC18P076822
GIFtS:
47
Genes Participants
UDN Logo

Aliases for ZNF236 Gene

Aliases for ZNF236 Gene

  • Zinc Finger Protein 236 2 3 5
  • Regulated By Glucose 3
  • ZNF236A 3
  • ZNF236B 3

External Ids for ZNF236 Gene

Previous GeneCards Identifiers for ZNF236 Gene

  • GC18P074159
  • GC18P074689
  • GC18P074299
  • GC18P072663
  • GC18P074536
  • GC18P071217

Summaries for ZNF236 Gene

GeneCards Summary for ZNF236 Gene

ZNF236 (Zinc Finger Protein 236) is a Protein Coding gene. Diseases associated with ZNF236 include Diabetes Mellitus, Insulin-Dependent, 6. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is SALL3.

UniProtKB/Swiss-Prot for ZNF236 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF236 Gene

Genomics for ZNF236 Gene

Products:

  1. Regulatory Element

Regulatory Elements for ZNF236 Gene

Enhancers for ZNF236 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18G076820 1.3 Ensembl ENCODE 11.4 +0.0 40 5.2 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF143 RNU6-346P ZNF236 GC18M076835
GH18G076983 1.4 Ensembl ENCODE dbSUPER 4.9 +161.1 161130 1.1 HDGF PKNOX1 TBL1XR1 RB1 KLF17 ZNF48 RAD21 GLIS2 ZNF143 IKZF2 RNU6-346P ZNF236 LOC105372217 ENSG00000279811
GH18G076981 1 ENCODE dbSUPER 6.2 +159.2 159193 1.1 TBP CTCF PKNOX1 MAX EBF1 RAD21 RFX5 RELA YY1 POLR2A RNU6-346P ZNF236 LOC105372217 ENSG00000279811
GH18G076838 1.1 Ensembl ENCODE 5.6 +16.1 16071 1.2 HDAC1 SOX13 CBX3 FOXA2 MAX ZBTB40 YY1 FOSL1 GATA2 CBX5 RNU6-346P ZNF236 ENSG00000275355 RPL26P35
GH18G076801 1.1 Ensembl ENCODE 5.3 -20.5 -20450 1.0 INSM2 KLF17 FEZF1 DMAP1 ZNF48 RAD21 GLIS2 ZNF143 EGR2 ZNF263 ZNF236 GC18P076804 RNU6-346P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF236 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF236 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000105211 39 3201 HDGF CREB3L1 ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 ZNF121 ZNF766

Genomic Location for ZNF236 Gene

Chromosome:
18
Start:
76,822,561 bp from pter
End:
76,970,732 bp from pter
Size:
148,172 bases
Orientation:
Plus strand

Genomic View for ZNF236 Gene

Genes around ZNF236 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF236 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF236 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ZNF236 Gene

Proteins for ZNF236 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for ZNF236 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UL36-ZN236_HUMAN
    Recommended name:
    Zinc finger protein 236
    Protein Accession:
    Q9UL36
    Secondary Accessions:
    • B2RTX9
    • Q9UL37

    Protein attributes for ZNF236 Gene

    Size:
    1845 amino acids
    Molecular mass:
    203704 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF236 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF236 Gene

Protein Expression for ZNF236 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ZNF236 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF236 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF236 Gene

Domains & Families for ZNF236 Gene

Gene Families for ZNF236 Gene

HGNC:

Protein Domains for ZNF236 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF236 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UL36

UniProtKB/Swiss-Prot:

ZN236_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF236: view

Function for ZNF236 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for ZNF236 Gene

GENATLAS Biochemistry:
zinc finger protein 236,(glucose regulated Kruppel-like),ubiquitously expressed
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF236 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF236: view
genes like me logo Genes that share phenotypes with ZNF236: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF236 Gene

Localization for ZNF236 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF236 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF236 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for ZNF236 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF236: view

Pathways & Interactions for ZNF236 Gene

SuperPathways for ZNF236 Gene

PathCards logo More details on SuperPathways for ZNF236
No Data Available

Gene Ontology (GO) - Biological Process for ZNF236 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0071333 cellular response to glucose stimulus IEP 9299475
genes like me logo Genes that share ontologies with ZNF236: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF236 Gene

Drugs & Compounds for ZNF236 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for ZNF236 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for ZNF236 Gene

(7) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(66) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF236 Gene

Zinc finger protein 236:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF236 Gene

No ASD Table

Relevant External Links for ZNF236 Gene

GeneLoc Exon Structure for
ZNF236
ECgene alternative splicing isoforms for
ZNF236

Expression for ZNF236 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF236 Gene

mRNA expression in normal human tissues for ZNF236 Gene
mRNA expression by BioGPS for ZNF236 GenemRNA expression by GTEx for ZNF236 Gene

Protein differential expression in normal tissues from HIPED for ZNF236 Gene

This gene is overexpressed in Frontal cortex (57.9) and Kidney (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF236 Gene



Protein tissue co-expression partners for ZNF236 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF236 Gene:

ZNF236

SOURCE GeneReport for Unigene cluster for ZNF236 Gene:

Hs.719137

mRNA Expression by UniProt/SwissProt for ZNF236 Gene:

Q9UL36-ZN236_HUMAN
Tissue specificity: Ubiquitous. Expression levels are highest in skeletal muscle and brain, intermediate in heart, pancreas, and placenta, and lowest in kidney, liver, and lung.

Evidence on tissue expression from TISSUES for ZNF236 Gene

  • Kidney(4.1)
genes like me logo Genes that share expression patterns with ZNF236: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF236 Gene

Orthologs for ZNF236 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZNF236 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ZNF236 34 35
  • 99.29 (n)
dog
(Canis familiaris)
 Mammalia ZNF236 34
  • 86.71 (n)
-- 35
  • 17 (a)
 ManyToMany
rat
(Rattus norvegicus)
 Mammalia Zfp236 34
  • 83.79 (n)
mouse
(Mus musculus)
 Mammalia Zfp236 34 16 35
  • 83.39 (n)
oppossum
(Monodelphis domestica)
 Mammalia ZNF236 35
  • 82 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia ZNF236 35
  • 80 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia ZNF236 34 35
  • 79.92 (n)
chicken
(Gallus gallus)
 Aves ZNF236 34 35
  • 74.84 (n)
lizard
(Anolis carolinensis)
 Reptilia ZNF236 35
  • 78 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia znf236 34
  • 70.44 (n)
Str.17000 34
African clawed frog
(Xenopus laevis)
 Amphibia Xl.5283 34
zebrafish
(Danio rerio)
 Actinopterygii znf236 35
  • 56 (a)
 OneToOne
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes FZF1 35
  • 23 (a)
 OneToMany
Species where no ortholog for ZNF236 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF236 Gene

ENSEMBL:
Gene Tree for ZNF236 (if available)
TreeFam:
Gene Tree for ZNF236 (if available)

Paralogs for ZNF236 Gene

Paralogs for ZNF236 Gene

(98) SIMAP similar genes for ZNF236 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF236: view

Variants for ZNF236 Gene

Sequence variations from dbSNP and Humsavar for ZNF236 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1000048008 -- 76,862,900(+) GTATC(A/G)ATATG intron-variant
rs1000054036 -- 76,958,673(+) GCTGT(C/T)GATGG intron-variant
rs1000060421 -- 76,936,476(+) GTTTC(C/T)CTTAG intron-variant
rs1000078624 -- 76,862,699(+) TCTGC(A/G)CTGTG intron-variant
rs1000121419 -- 76,949,701(+) TTGCC(A/C)AGGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF236 Gene

Variant ID Type Subtype PubMed ID
dgv1644n106 CNV duplication 24896259
dgv1645n106 CNV deletion 24896259
dgv1932e59 CNV duplication 20981092
esv2547601 CNV insertion 19546169
esv2588513 CNV deletion 19546169
esv2625456 CNV insertion 19546169
esv2717388 CNV deletion 23290073
esv2717421 CNV deletion 23290073
esv2717422 CNV deletion 23290073
esv2717423 CNV deletion 23290073
esv3331506 CNV duplication 20981092
esv3345401 CNV duplication 20981092
esv3376995 CNV insertion 20981092
esv3447107 CNV duplication 20981092
esv3555703 CNV deletion 23714750
esv3643197 CNV loss 21293372
esv3643199 CNV loss 21293372
nsv1056690 CNV gain 25217958
nsv1063632 CNV gain 25217958
nsv1071865 CNV deletion 25765185
nsv1077850 CNV duplication 25765185
nsv1129606 CNV tandem duplication 24896259
nsv1129608 CNV tandem duplication 24896259
nsv1130687 CNV deletion 24896259
nsv1135059 CNV deletion 24896259
nsv1140142 CNV insertion 24896259
nsv1143794 CNV deletion 24896259
nsv1146345 CNV duplication 26484159
nsv1152371 CNV deletion 26484159
nsv2363 CNV insertion 18451855
nsv477637 CNV novel sequence insertion 20440878
nsv960288 CNV duplication 23825009

Variation tolerance for ZNF236 Gene

Residual Variation Intolerance Score: 1.31% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.02; 68.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF236 Gene

Human Gene Mutation Database (HGMD)
ZNF236
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF236

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF236 Gene

Disorders for ZNF236 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF236 Gene - From: DISEASES

Disorder Aliases PubMed IDs
diabetes mellitus, insulin-dependent, 6
  • type 1 diabetes mellitus 6
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZNF236

Genetic Association Database (GAD)
ZNF236
Human Genome Epidemiology (HuGE) Navigator
ZNF236
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF236
genes like me logo Genes that share disorders with ZNF236: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF236 Gene

Publications for ZNF236 Gene

  1. Cloning and characterization of ZNF236, a glucose-regulated kruppel- like zinc-finger gene mapping to human chromosome 18q22-q23. (PMID: 10458916) Holmes D.I. … Mason R.M. (Genomics 1999) 2 3 4 64
  2. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 46 64
  3. Genetic analysis of diabetic nephropathy on chromosome 18 in African Americans: linkage analysis and dense SNP mapping. (PMID: 19690890) McDonough C.W. … Bowden D.W. (Hum. Genet. 2009) 3 46 64
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  5. Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. (PMID: 23648065) Low S.K. … Nakamura Y. (Cancer Sci. 2013) 3 64

Products for ZNF236 Gene

Sources for ZNF236 Gene

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