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Aliases for ZNF234 Gene

Aliases for ZNF234 Gene

  • Zinc Finger Protein 234 2 3 5
  • Zinc Finger Protein HZF4 3 4
  • Zinc Finger Protein 269 3 4
  • ZNF269 3 4
  • Zinc Finger Protein 234, Partial Sequence 3
  • C2-H2 Type Zinc Finger Protein 3
  • Homo Sapiens Zinc Finger 234 3
  • Zinc Finger Protein 4 3
  • HZF4 3

External Ids for ZNF234 Gene

Previous HGNC Symbols for ZNF234 Gene

  • ZNF269

Previous GeneCards Identifiers for ZNF234 Gene

  • GC19P045291
  • GC19P045037
  • GC19P049321
  • GC19P049337
  • GC19P044645
  • GC19P041077

Summaries for ZNF234 Gene

GeneCards Summary for ZNF234 Gene

ZNF234 (Zinc Finger Protein 234) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF226.

UniProtKB/Swiss-Prot for ZNF234 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF234 Gene

Genomics for ZNF234 Gene

Regulatory Elements for ZNF234 Gene

Enhancers for ZNF234 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F043751 1.5 FANTOM5 ENCODE 90.6 -385.7 -385654 8.9 CREB3L1 FEZF1 DMAP1 YBX1 YY1 ZNF143 ZNF416 ZNF548 ZNF263 SP3 ZNF180 ZNF45 ZNF234 ZNF224 ZNF284 ZNF225 ZNF230 XRCC1 SMG9 LOC100505715
GH19F043200 1.3 Ensembl ENCODE 98.2 -938.3 -938331 6.2 ZNF493 ZFP64 ARID4B DMAP1 FEZF1 GLI4 ZNF48 ZNF121 ZNF302 ZNF416 ZNF45 ZNF224 ZNF225 ZNF526 ZNF234 ZNF284 PSG4 XRCC1 ZNF230 IRGQ
GH19F044111 1.5 FANTOM5 ENCODE 78.9 -28.5 -28531 2.6 PKNOX1 MLX CREB3L1 ARID4B SIN3A ZNF2 YY1 ZNF302 ZNF416 ZNF207 ZNF180 ZNF45 ZNF234 ZNF224 ZNF155 ZNF225 ZNF284 XRCC1 ZNF230 LOC100379224
GH19F044164 1.1 ENCODE 89.7 +23.7 23720 1.8 PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF302 ZNF180 ZNF45 ZNF155 ZNF234 ZNF224 ZNF284 ZNF225 XRCC1 ZNF230 NECTIN2
GH19F044259 1.1 ENCODE 82.7 +118.5 118503 1.4 HDGF PKNOX1 ARID4B SIN3A YBX1 FEZF1 DMAP1 ZNF2 ZNF302 ZNF416 ZNF180 ZNF45 ZNF234 ZNF224 ZNF284 ZNF225 ZNF230 EXOC3L2 XRCC1 ZNF233
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF234 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF234 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001419399 271 2399 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF263 SP3 NFYC

Genomic Location for ZNF234 Gene

Chromosome:
19
Start:
44,141,530 bp from pter
End:
44,160,309 bp from pter
Size:
18,780 bases
Orientation:
Plus strand

Genomic View for ZNF234 Gene

Genes around ZNF234 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF234 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF234 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF234 Gene

Proteins for ZNF234 Gene

  • Protein details for ZNF234 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14588-ZN234_HUMAN
    Recommended name:
    Zinc finger protein 234
    Protein Accession:
    Q14588
    Secondary Accessions:
    • A8K1C8
    • Q96IR4
    • Q9NS45
    • Q9NYT7

    Protein attributes for ZNF234 Gene

    Size:
    700 amino acids
    Molecular mass:
    80560 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF234 Gene

Post-translational modifications for ZNF234 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF234 Gene

Domains & Families for ZNF234 Gene

Gene Families for ZNF234 Gene

Protein Domains for ZNF234 Gene

Suggested Antigen Peptide Sequences for ZNF234 Gene

Graphical View of Domain Structure for InterPro Entry

Q14588

UniProtKB/Swiss-Prot:

ZN234_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 19 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 19 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF234: view

Function for ZNF234 Gene

Molecular function for ZNF234 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF234 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF234: view
genes like me logo Genes that share phenotypes with ZNF234: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF234 Gene

Localization for ZNF234 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF234 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF234 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for ZNF234 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF234: view

Pathways & Interactions for ZNF234 Gene

SuperPathways for ZNF234 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF234: view

Pathways by source for ZNF234 Gene

2 Reactome pathways for ZNF234 Gene

Gene Ontology (GO) - Biological Process for ZNF234 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,IBA --
genes like me logo Genes that share ontologies with ZNF234: view

No data available for SIGNOR curated interactions for ZNF234 Gene

Transcripts for ZNF234 Gene

Unigene Clusters for ZNF234 Gene

Zinc finger protein 234:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF234 Gene

No ASD Table

Relevant External Links for ZNF234 Gene

GeneLoc Exon Structure for
ZNF234
ECgene alternative splicing isoforms for
ZNF234

Expression for ZNF234 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF234 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF234 Gene

This gene is overexpressed in Esophagus (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF234 Gene



Protein tissue co-expression partners for ZNF234 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF234 Gene:

ZNF234

SOURCE GeneReport for Unigene cluster for ZNF234 Gene:

Hs.235992
genes like me logo Genes that share expression patterns with ZNF234: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF234 Gene

Orthologs for ZNF234 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF234 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF234 34 35
  • 99.48 (n)
cow
(Bos Taurus)
Mammalia ZNF234 34
  • 86.84 (n)
dog
(Canis familiaris)
Mammalia ZNF234 34 35
  • 83.07 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9215 36
  • 43 (a)
CG5245 36
  • 42 (a)
CG17568 36
  • 36 (a)
CG2120 36
  • 36 (a)
CG6689 36
  • 36 (a)
EG:95B7.7 36
  • 35 (a)
CG7963 36
  • 34 (a)
CG17803 36
  • 33 (a)
CG6254 36
  • 33 (a)
CG10147 36
  • 32 (a)
CG7386 36
  • 31 (a)
CG8301 36
  • 29 (a)
CG10669 36
  • 25 (a)
Species where no ortholog for ZNF234 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF234 Gene

ENSEMBL:
Gene Tree for ZNF234 (if available)
TreeFam:
Gene Tree for ZNF234 (if available)

Paralogs for ZNF234 Gene

(580) SIMAP similar genes for ZNF234 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZNF234: view

Variants for ZNF234 Gene

Sequence variations from dbSNP and Humsavar for ZNF234 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10402702 -- 44,154,123(+) cctca(C/T)tggtg intron-variant
rs10406116 -- 44,151,597(+) gtcca(A/G)catgg intron-variant
rs10406464 -- 44,145,706(+) ATACT(A/C)TAACA intron-variant
rs10415664 -- 44,146,808(+) TCTCt(C/T)ttttt intron-variant
rs10417451 -- 44,140,346(+) TGGCA(C/T)GATCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNF234 Gene

Variant ID Type Subtype PubMed ID
nsv961227 CNV duplication 23825009
nsv833840 CNV gain 17160897
nsv1134795 CNV deletion 24896259
esv2718617 CNV deletion 23290073
esv2718616 CNV deletion 23290073
dgv526e201 CNV deletion 23290073

Variation tolerance for ZNF234 Gene

Residual Variation Intolerance Score: 91% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.63; 86.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF234 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF234

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF234 Gene

Disorders for ZNF234 Gene

Relevant External Links for ZNF234

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF234

No disorders were found for ZNF234 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF234 Gene

Publications for ZNF234 Gene

  1. Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937. (PMID: 7865130) Abrink M. … Hellman L. (DNA Cell Biol. 1995) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. (PMID: 12743021) Shannon M. … Stubbs L. (Genome Res. 2003) 3 4 64
  4. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp J.J. … Guthrie C. (Nat. Struct. Mol. Biol. 2015) 3 64
  5. The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability. (PMID: 23398456) Bett J.S. … Hay R.T. (Biochem. J. 2013) 3 64

Products for ZNF234 Gene

Sources for ZNF234 Gene

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