ZNF230 Gene
protein-coding GIFtS: 51
GCID: GC19P044507
|
|
zinc finger protein 230
| |
Aliases
for ZNF230 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 2301 2 | | FDZF21 2 3 | | Zinc Finger Protein FDZF22 3 |
Export aliases for ZNF230 gene to outside databasesPrevious GC identifers: GC19P045152 GC19P044898 GC19P049183 GC19P049198 GC19P049181 GC19P044270 |
Summaries
for ZNF230 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN230_HUMAN, Q9UIE0Function: May be involved in transcriptional regulation
|
Genomic Views
for ZNF230 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for ZNF230
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF230
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF230 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.31 Ensembl cytogenetic band: 19q13.31 HGNC cytogenetic band: 19q13.31ZNF230 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P044507: view genomic region
(about GC identifiers)
Start:
|
44,507,077 bp from pter |
End:
|
44,518,078 bp from pter |
Size:
|
11,002 bases |
Orientation:
|
plus strand |
|
Proteins
for ZNF230 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN230_HUMAN, Q9UIE0 (See
protein sequence)Recommended Name: Zinc finger protein 230 Size: 474 amino acids; 54542 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: O15322 Q504X7 Q86W84 Q9P1U6Explore the universe of human proteins at neXtProt for ZNF230: NX_Q9UIE0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UIE0
ZNF230 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_006291.2
ENSEMBL proteins: ENSP00000409318 ENSP00000465324 ENSP00000465988 ENSP00000466541 Reactome Protein details: Q9UIE0
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
ZNF230 for ontologies About GeneDecksing
ZNF230 Antibody Products:
Assay Products for ZNF230: |
Protein
Domains /
Families
for ZNF230 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF230 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UIE0ProtoNet protein and cluster: Q9UIE0 1 Blocks protein family: IPB001909 KRAB box
UniProtKB/Swiss-Prot: ZN230_HUMAN, Q9UIE0Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 10 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF230 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZN230_HUMAN, Q9UIE0Function: May be involved in transcriptional regulation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF230
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF230
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZNF230 (NM_006300) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF230 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF230 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF230 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
ZNF230 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZNF230 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF230
ZNF230 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF230
1 Interacting protein for ZNF230 (Q9UIE03) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF230 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF230 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF230
Search CenterWatch for drugs/clinical trials and news about ZNF230 / ZN230
|
Transcripts
for ZNF230 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF230 gene: NM_006300.3 Unigene Cluster for ZNF230: Zinc finger protein 230 Hs.193583 [show with all ESTs]Unigene Representative Sequence: NM_0063005 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000429154(uc002oyb.1) ENST00000589275 ENST00000585568 ENST00000585632
ENST00000585491
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF230
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF230
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF230 (NM_006300) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF230 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF230 |
Additional cDNA sequence: AF024701.1 AK056865.1 AK123773.1 BC030810.1 BC050340.1 BC066950.1 BC094708.1 U95044.1 3 DOTS entries: DT.410995 DT.91789273 DT.121451934 24/142 AceView cDNA sequences (see all 142): AA743568 AK056865 BM972262 AW590200 NM_003445 NM_198089 AK095196 BC050340 AW629037 F03655 AA743031 CA441594 BI752344 AK022875 BC075050 AA164237 AW300031 AA664446 BX369128 CD298795 AA235674 BI753642 AW071926 BQ184963
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF230 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 |
|---|
|
| SP1: | | | | | | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZNF230
|
Expression
for ZNF230 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF230 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTCCACACAG
About this image
Genevestigator expression for ZNF230
SOURCE GeneReport for Unigene cluster: Hs.193583
SABiosciences Custom PCR Arrays for ZNF230
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF230
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZNF230 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF230 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF230 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF230 |
Orthologs
for ZNF230 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for ZNF230 (if available)
TreeFam Gene Tree for ZNF230 (if available) |
Paralogs
for ZNF230 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF230 gene
- ZNF2292 ZNF2232 ENSG000000623702 ZNF1552 ZNF6642 ZNF2272 ZNF2342 ZNF2392
- ZNF2242 ZNF2252 ZNF2262 ZNF2142 ZNF2222 ZNF2842 ENSG000002671732 ZNF452
- ZNF2352 ZNF2212 ENSG000002670222 ZNF2852 ZNF2332
18/449 SIMAP similar genes for ZNF230 using alignment to 4 protein entries: ZN230_HUMAN (see all proteins)
(see all similar genes):ZNF222 ZNF224 ZNF155 ZNF596 ZNF223 ZNF225
ZNF221 ZNF234 ZNF705A ZNF624 ZNF124 ZNF78L1
ZNF226 ZFP90 ZFP112 ZNF229 ZNF235 ZNF625
ZNF230 for paralogs About GeneDecksing
|
Genomic Variants
for ZNF230 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF230 (44507077 - 44518078 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for ZNF230
2 CNVs: 58882 2245 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF230 |
|
Disorders
/ Diseases
for ZNF230 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF230 for disorders About GeneDecksing
5  diseases for ZNF230: About MalaCardslymphoblastic leukemia azoospermia pulmonary disease leukemia
schizophrenia
Genetic Association Database (GAD): ZNF230
Human Genome Epidemiology (HuGE) Navigator: ZNF230 (6 documents)
Export disorders for ZNF230 gene to outside databases
|
Publications
for ZNF230 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF230 gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with ZNF230) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Screening for ZNF230 gene mutation and analysis of its correlation with azoospermia. (PubMed id 15952109)1, 4 Dong J.T....Peng Y. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
- Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)1 Guey L.T....Malats N. (2010)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Spermatogenesis-related ring finger gene ZNF230 promo ter: identification and functional analysis. (PubMed id 18584306)1 Xu W....Zhang W. (2009)
- Germline genomic variants associated with childhood a cute lymphoblastic leukemia. (PubMed id 19684603)1 TreviA+o L.R....Relling M.V. (2009)
- PTEN identified as important risk factor of chronic o bstructive pulmonary disease. (PubMed id 19625176)1 Hosgood H.D....Lan Q. (2009)
- Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1 Shen M....Lan Q. (2009)
- Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)1 Hosgood H.D....Lan Q. (2008)
|
External Searches for ZNF230 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF230 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF230 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF230 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF230 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF230 gene:
Search GeneIP for patents involving ZNF230
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF230 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF230 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF230 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF230 | | | OriGene Protein Over-expression Lysate for ZNF230 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF230 | | OriGene 3'-UTR Clone for ZNF230 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF230 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF230 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ZNF230 | | OriGene Custom Protein Services for ZNF230 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF230 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF230 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF230 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF230 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF230 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF230 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for ZNF230 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | ZNF230 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF230 |
|  |  |  | | | | ThermoFisher Antibodies for ZNF230 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF230 |
|
|
|
|
