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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF23 Gene

protein-coding   GIFtS: 54
GCID: GC16M071481

zinc finger protein 23

(Previous name: zinc finger protein 359 )
(Previous symbol: ZNF359)
 Explore 4 diseases affiliated with
ZNF23 via our new
 Human Malady Compendium 
Biological research products
for ZNF23
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Zinc Finger Protein 231 2     Zinc Finger Protein 6122 3
KOX161 2 3 5     Zinc Finger Protein KOX162 3
Zinc Finger Protein 3591 2 3     Kruppel-Like Zinc Finger Factor X312
ZNF3591 2 3     Zinc Finger Protein 23 (KOX 16)2
ZNF6121 2 3     Zinc Finger Protein 322
Zfp6121 2     

External Ids:    HGNC: 130231   Entrez Gene: 75712   Ensembl: ENSG000001673777   OMIM: 1945275   UniProtKB: P170273   

Export aliases for ZNF23 gene to outside databases

Previous GC identifers: GC16U990062 GC16M072204 GC16M071216 GC16M071257 GC16M070039 GC16M057249


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZNF23_HUMAN, P17027
Function: May be involved in transcriptional regulation. May have a role in embryonic development

Gene Wiki entry for ZNF23


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF23 gene promoter:
         COUP-TF1   COUP   LUN-1   HNF-4alpha2   HNF-4alpha1   AREB6   PPAR-gamma1   COUP-TF   HFH-1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF23 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF23

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF23


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22   Ensembl cytogenetic band:  16q22.2   HGNC cytogenetic band: 16q22

ZNF23 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF23 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M071481:  view genomic region     (about GC identifiers)

Start:
71,481,500 bp from pter      End:
71,496,998 bp from pter
Size:
15,499 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZNF23_HUMAN, P17027 (See protein sequence)
Recommended Name: Zinc finger protein 23  
Size: 643 amino acids; 73059 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: Q96IT3 Q9UG42

Explore the universe of human proteins at neXtProt for ZNF23: NX_P17027

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P17027

  • ZNF23 Protein expression data from MOPED and PaxDb:    About this image 
    ZNF23 Protein Expression
    REFSEQ proteins: NP_666016.1  
    ENSEMBL proteins: 
     ENSP00000462429   ENSP00000377171   ENSP00000456683   ENSP00000349796   ENSP00000351535  
     ENSP00000454326   ENSP00000455280   ENSP00000395712   ENSP00000387673  
    Reactome Protein details: P17027
    Human Recombinant Protein Products for ZNF23: 
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    OriGene Protein Over-expression Lysate: ZNF23
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    Novus Biologicals ZNF23 Proteins
    Novus Biologicals ZNF23 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ZNF23

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF23 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for ZNF23


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ZNF23 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry P17027

    ProtoNet protein and cluster: P17027

    2 Blocks protein families:
    IPB001909 KRAB box
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZNF23_HUMAN, P17027
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 17 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZNF23_HUMAN, P17027
    Function: May be involved in transcriptional regulation. May have a role in embryonic development

         Genatlas biochemistry entry for ZNF23:
    zinc finger protein 23 (KOX16) (C2H2 type,Kruppel-like)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding IEA--
         
    ZNF23 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF23:
     Increased S DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ZNF23 

    miRNA
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    hsa-miR-582-3p hsa-miR-640
    SwitchGear 3'UTR luciferase reporter plasmidZNF23 3' UTR sequence
    Inhib. RNA
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    Clone
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF23


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Generic Transcription Pathway
    Generic Transcription Pathway1.00
    Gene Expression0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2        Reactome Pathways for ZNF23
        Generic Transcription Pathway
    Gene Expression



    ZNF23 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF23

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for ZNF23 (P170273 ENSP000003497964) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PCBD1P614573, ENSP000002992994I2D: score=1 STRING: ENSP00000299299
    ZBTB9Q96C003, ENSP000003785034I2D: score=1 STRING: ENSP00000378503
    GLRX3O760033I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF23 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF23
    Search CenterWatch for drugs/clinical trials and news about ZNF23 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF23 gene: 
    NM_145911.1  

    Unigene Cluster for ZNF23:

    Zinc finger protein 23
    Hs.656643  [show with all ESTs]
    Unigene Representative Sequence: BX537507
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000564528(uc002fad.3) ENST00000393539(uc002faf.3) ENST00000497160
    ENST00000357254(uc002fah.3) ENST00000358700 ENST00000539742 ENST00000565718
    ENST00000567340 ENST00000564588 ENST00000417828 ENST00000428724

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZNF23
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNF23:
    hsa-miR-582-3p hsa-miR-640
    SwitchGear 3'UTR luciferase reporter plasmidZNF23 3' UTR sequence
    Inhib. RNA
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    Sirion Biotech Custom design and validation of potent shRNA sequences against ZNF23 
    Clone
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF23
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF23

    Additional cDNA sequence: 

    AF024709.1 AF226996.1 AF507946.1 AK091039.1 AK297130.1 AL080123.1 AL833815.1 BC007256.1 
    BC048974.1 BT007400.1 BX537507.1 X52347.1 

    8 DOTS entries:

    DT.100756827  DT.100756801  DT.455222  DT.101983614  DT.101983615  DT.100756805  DT.95272841  DT.101972464 

    24/132 AceView cDNA sequences (see all 132):

    NM_145911 BF791623 CB265954 BT007400 AI879156 BQ000009 CR614408 BM310653 
    BU684801 CF890829 AA026601 BM022007 BM021862 AK091039 BM310950 BC048974 
    BX537507 BX098236 N45703 BC007256 AI937864 BM271734 NM_006961 X52343 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF23 (see all 11)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9a · 9b · 9c · 9d
    SP1:                                -                       -           -           -     -                 -                                 
    SP2:                                                        -                       -     -                 -     -                           
    SP3:        -                       -                       -     -                 -     -                                                   
    SP4:                                -                       -     -                 -     -                 -     -                           
    SP5:                                -                       -     -                 -     -                 -     -                           


    ECgene alternative splicing isoforms for ZNF23

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF23 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TATTACTTTT
    ZNF23 Expression
    About this image
    See ZNF23 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF23

    SOURCE GeneReport for Unigene cluster: Hs.656643
        SABiosciences Expression via Pathway-Focused PCR Array including ZNF23: 

              Cardiotoxicity in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF23

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
      --

    ENSEMBL Gene Tree for ZNF23 (if available)
    TreeFam Gene Tree for ZNF23 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF23 gene
    ZNF712  ZNF5862  ZNF5012  ZNF162  ZNF6232  ZFP22  ZNF3452  ZNF8522  
    ZFP32  ZNF5022  ZNF352  ZNF6602  ZKSCAN72  
    18/477 SIMAP similar genes for ZNF23 using alignment to 4 protein entries:     ZNF23_HUMAN (see all proteins) (see all similar genes):
    DKFZp571N1833    DKFZp686H20223    HZF36    SUN3    CCPG1    COX7A2
    LRTOMT    SCIMP    C12orf23    NDUFS7    FANCA    NSD1
    TGFBR3    ZNHIT3    IPO7    KLHDC1    SENP7    C11orf80

    ZNF23 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/285 NCBI SNPs in ZNF23 are shown (see all 285    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs735759221,2
    C--57262621(+) TGAGTA/CAGTAG 1 -- us2k12Minor allele frequency- C:0.28WA 120
    rs287093661,2
    F--57262807(+) AATATT/AATCAG 1 -- us2k11Minor allele frequency- A:0.24WA 118
    rs116444401,2
    H--57263351(+) accacA/Ccttaa 1 -- us2k10--------
    rs80514391,2
    C,F,A,H--57263839(+) CCCGCA/TAATAT 1 -- us2k116Minor allele frequency- T:0.27NS EA NA WA CSA 1293
    rs1137459891,2
    --57263849(+) TTCCAC/TCTTTT 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs763234281,2
    F--57264177(+) TGCTCC/TCCGGC 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs765851751,2
    F--57264557(+) TTAAAA/GACTAA 1 -- int11Minor allele frequency- G:0.03WA 118
    rs80587761,2
    C,F,H--71481109(+) TCCTCC/TTGCCT 1 -- int113Minor allele frequency- T:0.36NA WA CSA EA 375
    rs1431577681,2
    --71481145(+) AGGCAC/TATACC 1 -- int10--------
    rs1815490071,2
    --71481147(+) GCACAA/TACCAC 1 -- int10--------

    HapMap Linkage Disequilibrium report for ZNF23 (71481500 - 71496998 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ZNF23: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF23
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF23

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZNF23 for disorders           About GeneDecksing

    OMIM gene information: 194527    OMIM disorders: --

    4 diseases for ZNF23:    About MalaCards
    wolf-hirschhorn syndrome    sotos syndrome    ovarian cancer    carcinoma

    1 disease from the University of Copenhagen DISEASES database for ZNF23:
    Sotos syndrome

    Export disorders for ZNF23 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF23 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with ZNF23)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Identification and characterization of two novel zinc finger genes, ZNF359 and ZFP28, in human development. (PubMed id 12127974)1, 2 Zhou L.... Wu X. (2002)
    3. Multiple genes encoding zinc finger domains are expressed in human T cells. (PubMed id 2288909)1, 2 Thiesen H.-J. (1990)
    4. Human zinc finger gene ZNF23 (Kox16) maps to a zinc finger gene cluster on chromosome 16q22, and ZNF32 (Kox30) to chromosome region 10q23-q24. (PubMed id 8500793)1, 9 Cannizzaro L.A....Thiesen H.J. (1993)
    5. Expression of zinc finger 23 gene in human hepatocell ular carcinoma. (PubMed id 21965783)1 Shi Y....Xu N. (2011)
    6. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    7. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
    8. ZNF23 induces apoptosis in human ovarian cancer cells. (PubMed id 18384939)1 Huang C....Wang Y. (2008)
    9. Characterization of ZNF23, a KRAB-containing protein that is downregulated in human cancers and inhibits cell cycle progression. (PubMed id 17137575)1 Huang C....Wang Y. (2007)
    10. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7571 HGNC: 13023 AceView: ZNF19andZNF23 Ensembl:ENSG00000167377 euGenes: HUgn7571
    ECgene: ZNF23 H-InvDB: ZNF23

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    About This Section
    NameDescription
    PharmGKB entry for ZNF23 Pharmacogenomics, SNPs, Pathways

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    Patent Information for ZNF23 gene:
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