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Aliases for ZNF23 Gene

Aliases for ZNF23 Gene

  • Zinc Finger Protein 23 2 3 5
  • Zinc Finger Protein 359 2 3 4
  • Zinc Finger Protein 612 3 4
  • ZNF359 3 4
  • ZNF612 3 4
  • KOX16 3 4
  • Kruppel-Like Zinc Finger Factor X31 3
  • Zinc Finger Protein 23 (KOX 16) 3
  • Zinc Finger Protein KOX16 4
  • Zinc Finger Protein 32 3
  • Zfp612 3

External Ids for ZNF23 Gene

Previous HGNC Symbols for ZNF23 Gene

  • ZNF359

Previous GeneCards Identifiers for ZNF23 Gene

  • GC16U990062
  • GC16M072204
  • GC16M071216
  • GC16M071257
  • GC16M070039
  • GC16M071481
  • GC16M057249
  • GC16M071449
  • GC16M071450
  • GC16M071452
  • GC16M071455
  • GC16M071457

Summaries for ZNF23 Gene

GeneCards Summary for ZNF23 Gene

ZNF23 (Zinc Finger Protein 23) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF135.

UniProtKB/Swiss-Prot for ZNF23 Gene

  • May be involved in transcriptional regulation. May have a role in embryonic development.

Gene Wiki entry for ZNF23 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF23 Gene

Genomics for ZNF23 Gene

Regulatory Elements for ZNF23 Gene

Enhancers for ZNF23 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G071425 1.4 Ensembl ENCODE 24.8 +36.5 36483 1.7 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 SLC30A9 DHX38 SF3B3 ATXN1L ENSG00000247324 ZNF23 AP1G1 ZNF19 CALB2 PHLPP2 TRM-CAT2-1
GH16G071412 1.1 Ensembl ENCODE 22.8 +50.4 50418 1.0 ELF3 DRAP1 CTCF ZNF777 NFIB ARID4B MAX DMAP1 EBF1 ZNF48 ZNF23 ENSG00000247324 CALB2 ZNF19 ENSG00000262120 LOC105371332
GH16G071492 0.9 ENCODE 23.9 -29.1 -29138 0.2 PKNOX1 ATF1 ARNT TCF12 GATA2 NCOA1 ZNF592 MAFF SMARCA4 PBX2 ZNF23 ENSG00000247324 CALB2 TAT ENSG00000261611 LOC105371335
GH16G071563 1.1 ENCODE 17.1 -102.0 -102037 3.3 HDGF PKNOX1 FOXA2 MLX CREB3L1 ARNT SIN3A ARID4B DMAP1 ZNF2 PHLPP2 ZNF23 TAT-AS1 ENSG00000247324 DHODH HPR ZNF19 TAT
GH16G071459 1.1 ENCODE 12.7 +1.8 1772 3.1 HDGF HNRNPUL1 MLX ARNT CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF23 PHLPP2 MARVELD3 TXNL4B ENSG00000247324 GC16M071448 PIR35377
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF23 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF23 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000087646 252 1601 HDGF HNRNPUL1 MLX ARNT CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2

Genomic Location for ZNF23 Gene

Chromosome:
16
Start:
71,447,597 bp from pter
End:
71,463,095 bp from pter
Size:
15,499 bases
Orientation:
Minus strand

Genomic View for ZNF23 Gene

Genes around ZNF23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF23 Gene

Proteins for ZNF23 Gene

  • Protein details for ZNF23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17027-ZNF23_HUMAN
    Recommended name:
    Zinc finger protein 23
    Protein Accession:
    P17027
    Secondary Accessions:
    • Q8NDP5
    • Q96IT3
    • Q9UG42

    Protein attributes for ZNF23 Gene

    Size:
    643 amino acids
    Molecular mass:
    73059 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF23 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF23 Gene

Post-translational modifications for ZNF23 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF23 Gene

Domains & Families for ZNF23 Gene

Gene Families for ZNF23 Gene

Suggested Antigen Peptide Sequences for ZNF23 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P17027

UniProtKB/Swiss-Prot:

ZNF23_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF23: view

Function for ZNF23 Gene

Molecular function for ZNF23 Gene

GENATLAS Biochemistry:
zinc finger protein 23 (KOX16) (C2H2 type,Kruppel-like)
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation. May have a role in embryonic development.

Gene Ontology (GO) - Molecular Function for ZNF23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0005515 protein binding IPI 21516116
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF23: view
genes like me logo Genes that share phenotypes with ZNF23: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF23 Gene

Localization for ZNF23 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF23 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF23 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for ZNF23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF23: view

Pathways & Interactions for ZNF23 Gene

SuperPathways for ZNF23 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF23: view

Pathways by source for ZNF23 Gene

2 Reactome pathways for ZNF23 Gene

Gene Ontology (GO) - Biological Process for ZNF23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF23: view

No data available for SIGNOR curated interactions for ZNF23 Gene

Transcripts for ZNF23 Gene

Unigene Clusters for ZNF23 Gene

Zinc finger protein 23:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF23 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9a · 9b · 9c · 9d
SP1: - - - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - - - -
SP5: - - - - - - -
SP6: - - - - - -
SP7: - - - - -
SP8:
SP9: - - - -
SP10: - -
SP11: -

Relevant External Links for ZNF23 Gene

GeneLoc Exon Structure for
ZNF23
ECgene alternative splicing isoforms for
ZNF23

Expression for ZNF23 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF23 Gene

Protein differential expression in normal tissues from HIPED for ZNF23 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF23 Gene



Protein tissue co-expression partners for ZNF23 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF23 Gene:

ZNF23

SOURCE GeneReport for Unigene cluster for ZNF23 Gene:

Hs.656643

Evidence on tissue expression from TISSUES for ZNF23 Gene

  • Nervous system(4.4)
  • Muscle(4.2)
genes like me logo Genes that share expression patterns with ZNF23: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF23 Gene

Orthologs for ZNF23 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF23 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF23 34 35
  • 99.64 (n)
dog
(Canis familiaris)
Mammalia ZNF23 34 35
  • 89.74 (n)
cow
(Bos Taurus)
Mammalia ZNF23 34
  • 88.85 (n)
ZNF19 35
  • 54 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp612 34
  • 81.88 (n)
mouse
(Mus musculus)
Mammalia Zfp612 34 16 35
  • 79.65 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 55 (a)
OneToMany
-- 35
  • 54 (a)
OneToMany
-- 35
  • 53 (a)
OneToMany
-- 35
  • 52 (a)
OneToMany
-- 35
  • 52 (a)
OneToMany
-- 35
  • 50 (a)
OneToMany
Species where no ortholog for ZNF23 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF23 Gene

ENSEMBL:
Gene Tree for ZNF23 (if available)
TreeFam:
Gene Tree for ZNF23 (if available)

Paralogs for ZNF23 Gene

(502) SIMAP similar genes for ZNF23 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZNF23: view

Variants for ZNF23 Gene

Sequence variations from dbSNP and Humsavar for ZNF23 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000379998 -- 71,458,483(+) AGTTA(A/C/G)AGACT intron-variant
rs1000411217 -- 71,458,726(+) GAGAG(A/G)GCTAC intron-variant
rs1000490315 -- 71,451,892(+) TGAGG(A/G)TGGCC intron-variant
rs1000591883 -- 71,452,180(+) ATTAA(C/G)ACCTC intron-variant
rs1000869773 -- 71,447,293(+) TTGCT(A/G)TGTTG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for ZNF23 Gene

Variant ID Type Subtype PubMed ID
nsv1064435 CNV loss 25217958
nsv7285 OTHER inversion 18451855

Variation tolerance for ZNF23 Gene

Residual Variation Intolerance Score: 43.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.36; 26.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF23 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF23

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF23 Gene

Disorders for ZNF23 Gene

Relevant External Links for ZNF23

Genetic Association Database (GAD)
ZNF23
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF23

No disorders were found for ZNF23 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF23 Gene

Publications for ZNF23 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. Identification and characterization of two novel zinc finger genes, ZNF359 and ZFP28, in human development. (PMID: 12127974) Zhou L. … Wu X. (Biochem. Biophys. Res. Commun. 2002) 3 4 64
  3. Human zinc finger gene ZNF23 (Kox16) maps to a zinc finger gene cluster on chromosome 16q22, and ZNF32 (Kox30) to chromosome region 10q23-q24. (PMID: 8500793) Cannizzaro L.A. … Thiesen H.J. (Hum. Genet. 1993) 3 22 64
  4. Multiple genes encoding zinc finger domains are expressed in human T cells. (PMID: 2288909) Thiesen H.-J. (New Biol. 1990) 3 4 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for ZNF23 Gene

Sources for ZNF23 Gene

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