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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF229 Gene

protein-coding   GIFtS: 44
GCID: GC19M044930

Zinc Finger Protein 229

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 2291 2

External Ids:    HGNC: 130221   Entrez Gene: 77722   Ensembl: ENSG000001673837   UniProtKB: Q9UJW73   

Export aliases for ZNF229 gene to outside databases

Previous GC identifers: GC19M045578 GC19M045325 GC19M049609 GC19M049625 GC19M049626 GC19U900567 GC19M041362


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF229 Gene: 
ZNF229 (zinc finger protein 229) is a protein-coding gene. Diseases associated with ZNF229 include tuberculosis. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF223.

UniProtKB/Swiss-Prot: ZN229_HUMAN, Q9UJW7
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF229 gene promoter:
         Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF229 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF229

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF229


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.31   Ensembl cytogenetic band:  19q13.31   HGNC cytogenetic band: 19q13.2

ZNF229 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF229 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M044930:  view genomic region     (about GC identifiers)

Start:
44,921,685 bp from pter      End:
44,952,766 bp from pter
Size:
31,082 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN229_HUMAN, Q9UJW7 (See protein sequence)
Recommended Name: Zinc finger protein 229  
Size: 825 amino acids; 93707 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAG23970.1; Type=Erroneous gene model prediction;
Secondary accessions: B2RWN3 Q59FV2 Q86WL9

Explore the universe of human proteins at neXtProt for ZNF229: NX_Q9UJW7

Explore proteomics data for ZNF229 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UJW7

  • ZNF229 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF229 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001265439.1  NP_055333.2  

    ENSEMBL proteins: 
     ENSP00000291187   ENSP00000464897   ENSP00000466519   ENSP00000464902  

    Human Recombinant Protein Products for ZNF229: 
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    Cloud-Clone Corp. Proteins for ZNF229 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF229 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for ZNF229


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9UJW7

    ProtoNet protein and cluster: Q9UJW7

    2 Blocks protein domains:
    IPB001909 KRAB box
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZN229_HUMAN, Q9UJW7
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 18 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF229 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN229_HUMAN, Q9UJW7
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF229 for ontologies           About GeneDecksing


    Animal Models:
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    hsa-miR-1976 hsa-miR-150
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF229


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF229

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF229 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF229 (ZN229)

    Search CenterWatch for drugs/clinical trials and news about ZNF229 / ZN229

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF229 gene (2 alternative transcripts): 
    NM_001278510.1  NM_014518.2  

    Unigene Cluster for ZNF229:

    Zinc finger protein 229
    Hs.709348  [show with all ESTs]
    Unigene Representative Sequence: AB209357
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000591289 ENST00000291187(uc002oze.1 uc010ejk.1 uc010ejl.1)
    ENST00000591604 ENST00000588931 ENST00000592308
    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNF229:
    hsa-miR-1976 hsa-miR-150
    SwitchGear 3'UTR luciferase reporter plasmidZNF229 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ZNF229
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF229
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    GenScript: all cDNA clones in your preferred vector: ZNF229 (NM_014518)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF229
    Sirion Biotech Customized lentivirus for stable overexpression of ZNF229 
                         Customized lentivirus expression plasmids for stable overexpression of ZNF229 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ZNF229
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF229
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF229

    Additional mRNA sequence: 

    AB209357.1 AF192979.1 AK091541.1 AY166791.1 BC150612.1 CR936724.1 

    3 DOTS entries:

    DT.70100740  DT.100728877  DT.121499267 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF229    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6
    SP1:                                                  -         
    SP2:                                                            
    SP3:                                -                           


    ECgene alternative splicing isoforms for ZNF229

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF229 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGTAACCTC
    ZNF229 Expression
    About this image


    See ZNF229 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF229

    SOURCE GeneReport for Unigene cluster: Hs.709348
        SABiosciences Custom PCR Arrays for ZNF229
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF229
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF229

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ZNF229 gene from 4/5 species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia ZNF2291 zinc finger protein 229 80.64(n)
    76.89(a)
      100687726  XM_003432658.1  XP_003432706.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 4)
    --
    54(a)
    43(a)
    (see all 4)
    many → 1
    possible ortholog
    (see all 4)
    GL343884.1(112712-114268)
    AAWZ02037965(878-9727)
    zebrafish
    (Danio rerio)
    Actinopterygii CT990567.26
    CABZ01070854.16
    (see all 9)
    Uncharacterized protein
    (see all 9)
    54(a)
    45(a)
    (see all 9)
    many ↔ many
    many ↔ many
    (see all 9)
    4(48926599-48927610)
    Zv9_NA787(91847-94610)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG102743   -- 40(a)
    (best of 2)
      65A7   --


    ENSEMBL Gene Tree for ZNF229 (if available)
    TreeFam Gene Tree for ZNF229 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF229 gene
    ZNF2232  ZNF2302  ENSG000000623702  ZNF1552  ZNF2272  ZNF2242  ZNF2252  ZNF2262  
    ZNF2142  ZNF2222  ZNF2842  ENSG000002671732  ZNF452  ZNF2352  ZNF2212  ZNF2852  
    ENSG000002670222  ZNF2332  
    18/494 SIMAP similar genes for ZNF229 using alignment to 4 protein entries:     ZN229_HUMAN (see all proteins) (see all similar genes):
    ZNF124    ZNF155    ZNF235    ZNF78L1    ZNF224    ZNF225
    MGC12518    ZNF506    ZFS-4    ZNF169    ZNF226    ZNF846
    ZNF167    ZNF177    ZNF230    ZNF232    ZNF75A    ZNF763

    ZNF229 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/640 SNPs in ZNF229 are shown (see all 640)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1450756851,2
    --44929927(+) GGTCTC/GAGGGG 1 -- ds50010--------
    rs1875128551,2
    C--44930010(+) TTCATA/CCCTAC 1 -- ds50010--------
    rs1475762201,2
    C--44930019(+) ACCCCC/TTGCCC 1 -- ds50010--------
    rs1142977301,2
    F--44930048(+) CCCACG/AGTAAA 1 -- ds50011Minor allele frequency- A:0.01WA 118
    rs1490617201,2
    --44930091(+) CCCCAC/TCTCTT 1 -- ds50010--------
    rs44250031,2
    H--44930163(+) GTCTCC/TTGAGT 1 -- ds50014Minor allele frequency- T:0.00NS EA 420
    rs735648451,2
    C,F--44930240(+) TGTGGG/ACTCAC 1 -- ds50013Minor allele frequency- A:0.12WA CSA 122
    rs1177596311,2
    F--44930251(+) TAGTTC/GAAGAA 1 -- ds50011Minor allele frequency- G:0.02EA 120
    rs27344561,2
    C,F,A,H--44930348(-) AAATAT/CTCTCA 1 -- ds500134Minor allele frequency- C:0.47EA NA NS WA CSA 4205
    rs1134699461,2
    F--44930372(+) GTATGG/CCTTAT 1 -- ds50011Minor allele frequency- C:0.50CSA 2

    HapMap Linkage Disequilibrium report for ZNF229 (44921685 - 44952766 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for ZNF229:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2421963CNV Deletion20811451
    esv2663330CNV Deletion23128226
    nsv817849CNV Loss17921354
    nsv515911CNV Loss19592680
    dgv3944n71CNV Loss21882294
    esv26773CNV Loss19812545
    nsv9734CNV Gain+Loss18304495
    nsv442465CNV CNV18776908
    dgv1106e1CNV Complex17122850
    esv6503OTHER Inversion19470904

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for ZNF229:    About MalaCards
    tuberculosis    


    ZNF229 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZNF229

    Export disorders for ZNF229 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF229 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF229)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association analyses identifies a suscept ibility locus for tuberculosis on chromosome 18q11.2. (PubMed id 20694014)1, 4 Thye T....Hill A.V. (2010)
    2. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    3. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. (PubMed id 12743021)1, 2 Shannon M.... Stubbs L. (2003)
    4. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    6. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7772 HGNC: 13022 Ensembl:ENSG00000167383 euGenes: HUgn7772 ECgene: ZNF229
    H-InvDB: ZNF229

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF229 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF229 gene:
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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