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Aliases for ZNF227 Gene

Aliases for ZNF227 Gene

  • Zinc Finger Protein 227 2 3 5

External Ids for ZNF227 Gene

Previous GeneCards Identifiers for ZNF227 Gene

  • GC00U990433
  • GC19U900047
  • GC19P049408
  • GC19P044718
  • GC19P041148

Summaries for ZNF227 Gene

GeneCards Summary for ZNF227 Gene

ZNF227 (Zinc Finger Protein 227) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF229.

UniProtKB/Swiss-Prot for ZNF227 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF227 Gene

Genomics for ZNF227 Gene

Regulatory Elements for ZNF227 Gene

Enhancers for ZNF227 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF227 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF227 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF227 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF227 Gene

44,207,547 bp from pter
44,237,268 bp from pter
29,722 bases
Plus strand

Genomic View for ZNF227 Gene

Genes around ZNF227 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF227 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF227 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF227 Gene

Proteins for ZNF227 Gene

  • Protein details for ZNF227 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 227
    Protein Accession:
    Secondary Accessions:
    • B3KRU7
    • B7Z5P9

    Protein attributes for ZNF227 Gene

    799 amino acids
    Molecular mass:
    92033 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF227 Gene


neXtProt entry for ZNF227 Gene

Proteomics data for ZNF227 Gene at MOPED

Post-translational modifications for ZNF227 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF227 Gene

Domains & Families for ZNF227 Gene

Gene Families for ZNF227 Gene

Protein Domains for ZNF227 Gene

Suggested Antigen Peptide Sequences for ZNF227 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 19 C2H2-type zinc fingers.
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 19 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF227: view

Function for ZNF227 Gene

Molecular function for ZNF227 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF227 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ZNF227: view
genes like me logo Genes that share phenotypes with ZNF227: view

Animal Model Products

miRNA for ZNF227 Gene

miRTarBase miRNAs that target ZNF227

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF227 Gene

Localization for ZNF227 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF227 Gene

Subcellular locations from

Jensen Localization Image for ZNF227 Gene COMPARTMENTS Subcellular localization image for ZNF227 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF227 Gene

Pathways & Interactions for ZNF227 Gene

SuperPathways for ZNF227 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF227: view

Pathways by source for ZNF227 Gene

2 Reactome pathways for ZNF227 Gene

Gene Ontology (GO) - Biological Process for ZNF227 Gene


No data available for SIGNOR curated interactions for ZNF227 Gene

Drugs & Compounds for ZNF227 Gene

No Compound Related Data Available

Transcripts for ZNF227 Gene

Unigene Clusters for ZNF227 Gene

Zinc finger protein 227:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF227 Gene

No ASD Table

Relevant External Links for ZNF227 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF227 Gene

mRNA expression in normal human tissues for ZNF227 Gene

Protein differential expression in normal tissues from HIPED for ZNF227 Gene

This gene is overexpressed in Monocytes (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF227 Gene

SOURCE GeneReport for Unigene cluster for ZNF227 Gene Hs.298089

genes like me logo Genes that share expression patterns with ZNF227: view

Protein tissue co-expression partners for ZNF227 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF227 Gene

Orthologs for ZNF227 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF227 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZNF227 35
  • 80.62 (n)
  • 83.98 (a)
(Canis familiaris)
Mammalia ZNF227 35
  • 88.12 (n)
  • 86.57 (a)
(Pan troglodytes)
Mammalia ZNF227 35
  • 99.58 (n)
  • 99.75 (a)
ZNF227 36
  • 100 (a)
Species with no ortholog for ZNF227:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF227 Gene

Gene Tree for ZNF227 (if available)
Gene Tree for ZNF227 (if available)

Paralogs for ZNF227 Gene

(525) SIMAP similar genes for ZNF227 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with ZNF227: view

Variants for ZNF227 Gene

Sequence variations from dbSNP and Humsavar for ZNF227 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs7259916 -- 44,226,203(+) GGGTG(C/T)CTCCC intron-variant
rs7260304 -- 44,213,825(+) ATCCT(A/G)CAACA intron-variant
rs7508523 -- 44,217,252(+) agcca(C/T)tgtgc intron-variant
rs12980583 -- 44,230,926(+) aaaaa(A/T)atata intron-variant
rs8102037 -- 44,233,686(+) aggtc(A/G)ggagt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF227 Gene

Variant ID Type Subtype PubMed ID
nsv2505 CNV Insertion 18451855

Variation tolerance for ZNF227 Gene

Residual Variation Intolerance Score: 16.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.28; 53.06% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF227 Gene

Disorders for ZNF227 Gene

Relevant External Links for ZNF227

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF227 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF227 Gene

Publications for ZNF227 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 3
  4. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
  5. Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. (PMID: 20562864) Nozawa R.S. … Obuse C. (Nat. Cell Biol. 2010) 3

Products for ZNF227 Gene

Sources for ZNF227 Gene