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Aliases for ZNF227 Gene

Aliases for ZNF227 Gene

  • Zinc Finger Protein 227 2 3

External Ids for ZNF227 Gene

Previous GeneCards Identifiers for ZNF227 Gene

  • GC00U990433
  • GC19U900047
  • GC19P049408
  • GC19P044718
  • GC19P041148

Summaries for ZNF227 Gene

GeneCards Summary for ZNF227 Gene

ZNF227 (Zinc Finger Protein 227) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF155.

UniProtKB/Swiss-Prot for ZNF227 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF227 Gene

Genomics for ZNF227 Gene

Regulatory Elements for ZNF227 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF227 Gene

44,207,547 bp from pter
44,237,268 bp from pter
29,722 bases
Plus strand

Genomic View for ZNF227 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF227 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF227 Gene

Proteins for ZNF227 Gene

  • Protein details for ZNF227 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 227
    Protein Accession:
    Secondary Accessions:
    • B3KRU7
    • B7Z5P9

    Protein attributes for ZNF227 Gene

    799 amino acids
    Molecular mass:
    92033 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF227 Gene


neXtProt entry for ZNF227 Gene

Proteomics data for ZNF227 Gene at MOPED

Post-translational modifications for ZNF227 Gene

  • Ubiquitination at Lys574 and Lys577
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for ZNF227 Gene

Domains for ZNF227 Gene

Gene Families for ZNF227 Gene

  • ZNF :Zinc fingers, C2H2-type

Suggested Antigen Peptide Sequences for ZNF227 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q86WZ6
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 19 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF227: view

Function for ZNF227 Gene

Molecular function for ZNF227 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF227 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IBA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF227: view

Phenotypes for ZNF227 Gene

genes like me logo Genes that share phenotypes with ZNF227: view

miRNA for ZNF227 Gene

miRTarBase miRNAs that target ZNF227

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF227 Gene

Localization for ZNF227 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF227 Gene

Subcellular locations from

Jensen Localization Image for ZNF227 Gene COMPARTMENTS Subcellular localization image for ZNF227 gene
Compartment Confidence
nucleus 4
cytosol 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ZNF227 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF227: view

Pathways for ZNF227 Gene

SuperPathways for ZNF227 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF227: view

Pathways by source for ZNF227 Gene

2 Reactome pathways for ZNF227 Gene

Gene Ontology (GO) - Biological Process for ZNF227 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF227: view

Transcripts for ZNF227 Gene

Unigene Clusters for ZNF227 Gene

Zinc finger protein 227:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF227

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF227 Gene

No ASD Table

Relevant External Links for ZNF227 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF227 Gene

mRNA expression in normal human tissues for ZNF227 Gene

Protein differential expression in normal tissues for ZNF227 Gene

This gene is overexpressed in Monocytes (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZNF227 Gene

SOURCE GeneReport for Unigene cluster for ZNF227 Gene Hs.298089

genes like me logo Genes that share expressions with ZNF227: view

Expression partners for ZNF227 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF227 Gene

Orthologs for ZNF227 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF227 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZNF227 35
  • 80.62 (n)
  • 83.98 (a)
(Canis familiaris)
Mammalia ZNF227 35
  • 88.12 (n)
  • 86.57 (a)
(Pan troglodytes)
Mammalia ZNF227 35
  • 99.58 (n)
  • 99.75 (a)
ZNF227 36
  • 100 (a)
Species with no ortholog for ZNF227:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF227 Gene

Gene Tree for ZNF227 (if available)
Gene Tree for ZNF227 (if available)

Paralogs for ZNF227 Gene

Selected SIMAP similar genes for ZNF227 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with ZNF227: view

Variants for ZNF227 Gene

Sequence variations from dbSNP and Humsavar for ZNF227 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs11140 -- 44,237,082(-) ATTCA(A/C)AATGA utr-variant-3-prime
rs922063 -- 44,228,505(+) CTGCT(C/G)GATCT reference, synonymous-codon, utr-variant-5-prime
rs922064 -- 44,228,682(+) AAGAC(A/G)AAAGG intron-variant
rs1233454 -- 44,237,674(-) TGAGA(C/T)GGAGT downstream-variant-500B
rs1233455 -- 44,215,082(+) atccg(G/T)ggaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF227 Gene

Variant ID Type Subtype PubMed ID
nsv2505 CNV Insertion 18451855

Relevant External Links for ZNF227 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF227 Gene

Disorders for ZNF227 Gene

No disorders were found for ZNF227 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for ZNF227 Gene

Publications for ZNF227 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Identification of novel ARF binding proteins by two-hybrid screening. (PMID: 16582619) Tompkins V. … Quelle D.E. (Cell Cycle 2006) 3
  4. Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. (PMID: 20562864) Nozawa R.S. … Obuse C. (Nat. Cell Biol. 2010) 3
  5. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 3

Products for ZNF227 Gene

Sources for ZNF227 Gene

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