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Aliases for ZNF227 Gene

Aliases for ZNF227 Gene

  • Zinc Finger Protein 227 2 3 5

External Ids for ZNF227 Gene

Previous GeneCards Identifiers for ZNF227 Gene

  • GC00U990433
  • GC19U900047
  • GC19P049408
  • GC19P044718
  • GC19P041148

Summaries for ZNF227 Gene

GeneCards Summary for ZNF227 Gene

ZNF227 (Zinc Finger Protein 227) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF226.

UniProtKB/Swiss-Prot for ZNF227 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF227 Gene

Genomics for ZNF227 Gene

Regulatory Elements for ZNF227 Gene

Enhancers for ZNF227 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F044268 0.3 FANTOM5 12.6 +61.5 61544 0.3 ZNF280D ZNF366 IKZF1 NFE2 ZNF7 ZNF227 ZNF226 ZNF229 ZNF155 ZNF285 ZNF112 ZNF233 LYPD5 ZNF221 ZNF235
GH19F044245 0.3 FANTOM5 2.5 +38.0 38016 0.3 ZBTB10 RBAK ADNP CHD1 ZBTB40 ZNF226 ZNF229 ZNF112 ZNF285 ZNF221 ZNF227 ZNF233 ZNF235 LYPD5 ZNF234
GH19F044316 0.3 FANTOM5 1.4 +109.6 109587 0.3 KLF1 KLF17 ZNF233 ZNF229 ZNF112 ZNF221 ZNF285 ZNF223 ZNF284 ZNF180 ZNF227 PIR37551
GH19F044206 0.4 ENCODE 0.8 +0.0 36 1.4 PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF302 CBX5 ZNF416 ZNF45 ZNF180 ZNF234 ZNF225 ZNF224 ZNF284 XRCC1 ZNF223 ZNF230 NECTIN2
GH19F044211 1 ENCODE 0.4 +5.2 5152 1.7 CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF302 ZNF416 ZNF180 ZNF45 ZNF234 ZNF155 ZNF224 ZNF284 XRCC1 ENSG00000266958 NECTIN2 ZNF225
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZNF227 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF227 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001817914 354 1799 PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF302 CBX5 ZNF416

Genomic Location for ZNF227 Gene

Chromosome:
19
Start:
44,207,547 bp from pter
End:
44,237,268 bp from pter
Size:
29,722 bases
Orientation:
Plus strand

Genomic View for ZNF227 Gene

Genes around ZNF227 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF227 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF227 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF227 Gene

Proteins for ZNF227 Gene

  • Protein details for ZNF227 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86WZ6-ZN227_HUMAN
    Recommended name:
    Zinc finger protein 227
    Protein Accession:
    Q86WZ6
    Secondary Accessions:
    • B3KRU7
    • B7Z5P9

    Protein attributes for ZNF227 Gene

    Size:
    799 amino acids
    Molecular mass:
    92033 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF227 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF227 Gene

Post-translational modifications for ZNF227 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF227 Gene

Domains & Families for ZNF227 Gene

Gene Families for ZNF227 Gene

Suggested Antigen Peptide Sequences for ZNF227 Gene

Graphical View of Domain Structure for InterPro Entry

Q86WZ6

UniProtKB/Swiss-Prot:

ZN227_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 19 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 19 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF227: view

Function for ZNF227 Gene

Molecular function for ZNF227 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF227 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF227: view
genes like me logo Genes that share phenotypes with ZNF227: view

Animal Model Products

miRNA for ZNF227 Gene

miRTarBase miRNAs that target ZNF227

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF227 Gene

Localization for ZNF227 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF227 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF227 Gene COMPARTMENTS Subcellular localization image for ZNF227 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for ZNF227 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF227: view

Pathways & Interactions for ZNF227 Gene

SuperPathways for ZNF227 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF227: view

Pathways by source for ZNF227 Gene

2 Reactome pathways for ZNF227 Gene

Gene Ontology (GO) - Biological Process for ZNF227 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
GO:0045892 negative regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF227: view

No data available for SIGNOR curated interactions for ZNF227 Gene

Transcripts for ZNF227 Gene

Unigene Clusters for ZNF227 Gene

Zinc finger protein 227:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF227 Gene

No ASD Table

Relevant External Links for ZNF227 Gene

GeneLoc Exon Structure for
ZNF227
ECgene alternative splicing isoforms for
ZNF227

Expression for ZNF227 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF227 Gene

Protein differential expression in normal tissues from HIPED for ZNF227 Gene

This gene is overexpressed in Monocytes (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF227 Gene



Protein tissue co-expression partners for ZNF227 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF227 Gene:

ZNF227

SOURCE GeneReport for Unigene cluster for ZNF227 Gene:

Hs.298089
genes like me logo Genes that share expression patterns with ZNF227: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF227 Gene

Orthologs for ZNF227 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF227 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF227 34 35
  • 99.58 (n)
dog
(Canis familiaris)
Mammalia ZNF227 34
  • 88.12 (n)
cow
(Bos Taurus)
Mammalia ZNF227 34
  • 80.62 (n)
Species where no ortholog for ZNF227 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF227 Gene

ENSEMBL:
Gene Tree for ZNF227 (if available)
TreeFam:
Gene Tree for ZNF227 (if available)

Paralogs for ZNF227 Gene

(525) SIMAP similar genes for ZNF227 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with ZNF227: view

Variants for ZNF227 Gene

Sequence variations from dbSNP and Humsavar for ZNF227 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10153465 -- 44,206,514(+) CGCCC(A/G)ACTAA upstream-variant-2KB
rs10405281 -- 44,211,155(+) CCGAG(A/G)TCATG intron-variant, upstream-variant-2KB
rs10406495 -- 44,205,926(+) TACTT(C/T)TGAAA upstream-variant-2KB
rs10406704 -- 44,227,500(+) gcctc(A/G)gcctc intron-variant, upstream-variant-2KB
rs10406980 -- 44,227,069(+) AAATC(A/T)TCAGT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNF227 Gene

Variant ID Type Subtype PubMed ID
esv3387904 CNV duplication 20981092
nsv2505 CNV insertion 18451855

Variation tolerance for ZNF227 Gene

Residual Variation Intolerance Score: 16.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.28; 53.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF227 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF227

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF227 Gene

Disorders for ZNF227 Gene

Relevant External Links for ZNF227

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF227

No disorders were found for ZNF227 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF227 Gene

Publications for ZNF227 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  4. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 3 64
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3 64

Products for ZNF227 Gene

Sources for ZNF227 Gene

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