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Aliases for ZNF226 Gene

Aliases for ZNF226 Gene

  • Zinc Finger Protein 226 2 3 5

External Ids for ZNF226 Gene

Previous GeneCards Identifiers for ZNF226 Gene

  • GC19P045314
  • GC19P045060
  • GC19P049345
  • GC19P049361
  • GC19P049355
  • GC19P044669
  • GC19P041101
  • GC19P044647

Summaries for ZNF226 Gene

GeneCards Summary for ZNF226 Gene

ZNF226 (Zinc Finger Protein 226) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF229.

UniProtKB/Swiss-Prot for ZNF226 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF226 Gene

Genomics for ZNF226 Gene

Regulatory Elements for ZNF226 Gene

Enhancers for ZNF226 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF226 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF226 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF226 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF226 Gene

44,165,062 bp from pter
44,178,381 bp from pter
13,320 bases
Plus strand

Genomic View for ZNF226 Gene

Genes around ZNF226 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF226 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF226 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF226 Gene

Proteins for ZNF226 Gene

  • Protein details for ZNF226 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 226
    Protein Accession:
    Secondary Accessions:
    • Q8WWE6
    • Q96TE6
    • Q9NS44

    Protein attributes for ZNF226 Gene

    803 amino acids
    Molecular mass:
    91921 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF226 Gene


neXtProt entry for ZNF226 Gene

Proteomics data for ZNF226 Gene at MOPED

Post-translational modifications for ZNF226 Gene

  • Ubiquitination at Lys 53
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZNF226 Gene

Domains & Families for ZNF226 Gene

Gene Families for ZNF226 Gene

Protein Domains for ZNF226 Gene

Suggested Antigen Peptide Sequences for ZNF226 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 19 C2H2-type zinc fingers.
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 19 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF226: view

Function for ZNF226 Gene

Molecular function for ZNF226 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF226: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF226 Gene

Localization for ZNF226 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF226 Gene

Subcellular locations from

Jensen Localization Image for ZNF226 Gene COMPARTMENTS Subcellular localization image for ZNF226 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF226 Gene

Pathways & Interactions for ZNF226 Gene

SuperPathways for ZNF226 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF226: view

Pathways by source for ZNF226 Gene

2 Reactome pathways for ZNF226 Gene

Gene Ontology (GO) - Biological Process for ZNF226 Gene


No data available for SIGNOR curated interactions for ZNF226 Gene

Drugs & Compounds for ZNF226 Gene

No Compound Related Data Available

Transcripts for ZNF226 Gene

Unigene Clusters for ZNF226 Gene

Zinc finger protein 226:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF226 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b ^ 10a · 10b · 10c · 10d · 10e
SP1: - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - -
SP4: - - - - - - -
SP5: - - - - - -
SP6: - - - - - - - -
SP7: -
SP8: - - - - - -
SP9: - - - - - - - - -
SP10: - - - -
SP11: - - - - -
SP12: - - -

Relevant External Links for ZNF226 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF226 Gene

mRNA expression in normal human tissues for ZNF226 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for ZNF226 Gene Hs.145956

genes like me logo Genes that share expression patterns with ZNF226: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZNF226 Gene

Orthologs for ZNF226 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF226 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia ZNF226 35
  • 86.16 (n)
  • 83.29 (a)
-- 36
  • 67 (a)
(Mus musculus)
Mammalia Zfp111 35
  • 64.07 (n)
  • 59.28 (a)
Zfp111 16
Zfp61 36
  • 57 (a)
(Pan troglodytes)
Mammalia ZNF226 35
  • 99.42 (n)
  • 98.88 (a)
ZNF226 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Zfp111 35
  • 62.48 (n)
  • 55.23 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5245 35
  • 47.77 (n)
  • 42.63 (a)
Species with no ortholog for ZNF226:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF226 Gene

Gene Tree for ZNF226 (if available)
Gene Tree for ZNF226 (if available)

Paralogs for ZNF226 Gene

genes like me logo Genes that share paralogs with ZNF226: view

Variants for ZNF226 Gene

Sequence variations from dbSNP and Humsavar for ZNF226 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs7257833 -- 44,171,121(+) TTTTA(C/T)TGTTT intron-variant
rs7260367 -- 44,174,753(+) CTTTC(C/T)ATACC intron-variant
rs8105479 -- 44,164,224(+) ttcat(C/T)ggaca upstream-variant-2KB
rs16978794 -- 44,170,973(+) TTGTA(A/T)GTACT intron-variant
rs67085261 -- 44,174,140(+) CTCTT(-/TG)TGTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF226 Gene

Variant ID Type Subtype PubMed ID
nsv833840 CNV Gain 17160897

Variation tolerance for ZNF226 Gene

Residual Variation Intolerance Score: 87.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.21; 62.07% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF226 Gene

Disorders for ZNF226 Gene

Relevant External Links for ZNF226

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF226 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF226 Gene

Publications for ZNF226 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  3. An atlas of combinatorial transcriptional regulation in mouse and man. (PMID: 20211142) Ravasi T. … Hayashizaki Y. (Cell 2010) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for ZNF226 Gene

Sources for ZNF226 Gene