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Aliases for ZNF225 Gene

Aliases for ZNF225 Gene

  • Zinc Finger Protein 225 2 3

External Ids for ZNF225 Gene

Previous GeneCards Identifiers for ZNF225 Gene

  • GC19P045263
  • GC19P045009
  • GC19P049293
  • GC19P049309
  • GC19P044269
  • GC19P044617

Summaries for ZNF225 Gene

GeneCards Summary for ZNF225 Gene

ZNF225 (Zinc Finger Protein 225) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF155.

UniProtKB/Swiss-Prot for ZNF225 Gene

  • May be involved in transcriptional regulation

Gene Wiki entry for ZNF225 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF225 Gene

Genomics for ZNF225 Gene

Genomic Location for ZNF225 Gene

Chromosome:
19
Start:
44,112,076 bp from pter
End:
44,134,816 bp from pter
Size:
22,741 bases
Orientation:
Plus strand

Genomic View for ZNF225 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF225 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF225 Gene

No data available for Regulatory Elements for ZNF225 Gene

Proteins for ZNF225 Gene

  • Protein details for ZNF225 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UK10-ZN225_HUMAN
    Recommended name:
    Zinc finger protein 225
    Protein Accession:
    Q9UK10
    Secondary Accessions:
    • A8K8S2
    • Q53F12
    • Q9NS46
    • Q9UID8

    Protein attributes for ZNF225 Gene

    Size:
    706 amino acids
    Molecular mass:
    82471 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF225 Gene

Proteomics data for ZNF225 Gene at MOPED

Post-translational modifications for ZNF225 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF225 Gene

No data available for DME Specific Peptides for ZNF225 Gene

Domains & Families for ZNF225 Gene

Gene Families for ZNF225 Gene

Protein Domains for ZNF225 Gene

Suggested Antigen Peptide Sequences for ZNF225 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UK10

UniProtKB/Swiss-Prot:

ZN225_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 18 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 18 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF225: view

Function for ZNF225 Gene

Molecular function for ZNF225 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF225 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF225: view
genes like me logo Genes that share phenotypes with ZNF225: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF225

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF225 Gene

Localization for ZNF225 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF225 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF225 Gene COMPARTMENTS Subcellular localization image for ZNF225 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for ZNF225 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF225: view

Pathways & Interactions for ZNF225 Gene

SuperPathways for ZNF225 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF225: view

Pathways by source for ZNF225 Gene

2 Reactome pathways for ZNF225 Gene

Interacting Proteins for ZNF225 Gene

Gene Ontology (GO) - Biological Process for ZNF225 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF225: view

No data available for SIGNOR curated interactions for ZNF225 Gene

Drugs & Compounds for ZNF225 Gene

No Compound Related Data Available

Transcripts for ZNF225 Gene

Unigene Clusters for ZNF225 Gene

Zinc finger protein 225:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF225

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF225 Gene

No ASD Table

Relevant External Links for ZNF225 Gene

GeneLoc Exon Structure for
ZNF225
ECgene alternative splicing isoforms for
ZNF225

Expression for ZNF225 Gene

mRNA expression in normal human tissues for ZNF225 Gene

Protein differential expression in normal tissues from HIPED for ZNF225 Gene

This gene is overexpressed in NK cells (32.9) and Monocytes (30.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF225 Gene



SOURCE GeneReport for Unigene cluster for ZNF225 Gene Hs.279567

genes like me logo Genes that share expression patterns with ZNF225: view

Protein tissue co-expression partners for ZNF225 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF225 Gene

Orthologs for ZNF225 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF225 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF225 35
  • 99.48 (n)
  • 99.15 (a)
ZNF225 36
  • 99 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG10669 37
  • 28 (a)
CG17568 37
  • 35 (a)
EG:95B7.7 37
  • 33 (a)
Kr 37
  • 48 (a)
Species with no ortholog for ZNF225:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF225 Gene

ENSEMBL:
Gene Tree for ZNF225 (if available)
TreeFam:
Gene Tree for ZNF225 (if available)

Paralogs for ZNF225 Gene

(471) SIMAP similar genes for ZNF225 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZNF225: view

Variants for ZNF225 Gene

Sequence variations from dbSNP and Humsavar for ZNF225 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1052493 -- 44,134,384(+) CTACC(A/G)GTTAT utr-variant-3-prime, nc-transcript-variant
rs1052494 -- 44,134,619(+) ACACT(C/T)AGCAG utr-variant-3-prime, nc-transcript-variant
rs1236711 -- 44,133,678(+) TAGGA(A/C)AAAGA utr-variant-3-prime, nc-transcript-variant
rs1236712 -- 44,133,841(+) TCTAC(C/T)AGAGA utr-variant-3-prime, intron-variant
rs1236713 -- 44,134,317(+) tctgg(G/T)acata utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF225 Gene

Variant ID Type Subtype PubMed ID
nsv833840 CNV Gain 17160897

Variation tolerance for ZNF225 Gene

Residual Variation Intolerance Score: 95.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.69; 73.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF225 Gene

HapMap Linkage Disequilibrium report
ZNF225

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF225 Gene

Disorders for ZNF225 Gene

Relevant External Links for ZNF225

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF225
genes like me logo Genes that share disorders with ZNF225: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF225 Gene

Publications for ZNF225 Gene

  1. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 67
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 67
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67
  5. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. (PMID: 12743021) Shannon M. … Stubbs L. (Genome Res. 2003) 67

Products for ZNF225 Gene

Sources for ZNF225 Gene

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