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ZNF225 Gene

protein-coding   GIFtS: 46
GCID: GC19P044617

Zinc Finger Protein 225

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 2251 2
C2-H2 Type Zinc Finger Protein2

External Ids:    HGNC: 130181   Entrez Gene: 77682   Ensembl: ENSG000002562947   UniProtKB: Q9UK103   

Export aliases for ZNF225 gene to outside databases

Previous GC identifers: GC19P045263 GC19P045009 GC19P049293 GC19P049309 GC19P044269


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF225 Gene:
ZNF225 (zinc finger protein 225) is a protein-coding gene. An important paralog of this gene is ZNF229.

UniProtKB/Swiss-Prot: ZN225_HUMAN, Q9UK10
Function: May be involved in transcriptional regulation

Gene Wiki entry for ZNF225 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for ZNF225
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF225 promoter sequence
   Search Chromatin IP Primers for ZNF225

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF225


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.31   HGNC cytogenetic band: 19q13.31

ZNF225 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF225 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P044617:  view genomic region     (about GC identifiers)

Start:
44,616,334 bp from pter      End:
44,637,255 bp from pter
Size:
20,922 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZN225_HUMAN, Q9UK10 (See protein sequence)
Recommended Name: Zinc finger protein 225  
Size: 706 amino acids; 82471 Da
Secondary accessions: A8K8S2 Q53F12 Q9NS46 Q9UID8

Explore the universe of human proteins at neXtProt for ZNF225: NX_Q9UK10

Explore proteomics data for ZNF225 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF225 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_037494.2  
    ENSEMBL proteins: 
     ENSP00000466853   ENSP00000262894   ENSP00000468414   ENSP00000466889   ENSP00000468686  
    Reactome Protein details: Q9UK10

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9UK10

    ProtoNet protein and cluster: Q9UK10

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN225_HUMAN, Q9UK10
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 18 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    Find genes that share domains with ZNF225           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN225_HUMAN, Q9UK10
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF225           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for ZNF225:
     Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa  Increased cell death HMECs cel 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ZNF225

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN225_HUMAN, Q9UK10: Nucleus (Probable)

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZNF225           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF225 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40


    Find genes that share SuperPaths with ZNF225           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF225
        Generic Transcription Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF225
    Interactions:

        Search GeneGlobe Interaction Network for ZNF225

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for ZNF225 (ENSP000002628944) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SNAI1ENSP000002440504STRING: ENSP00000244050
    SP1ENSP000003293574STRING: ENSP00000329357
    CBX3ENSP000003366874STRING: ENSP00000336687
    NDEL1ENSP000003339824STRING: ENSP00000333982
    SREBF2ENSP000003544764STRING: ENSP00000354476
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with ZNF225           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF225 (ZN225)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF225 gene: 
    NM_013362.2  

    Unigene Cluster for ZNF225:

    Zinc finger protein 225
    Hs.279567  [show with all ESTs]
    Unigene Representative Sequence: NM_013362
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000589155 ENST00000262894(uc002oyj.1 uc010ejf.1) ENST00000588926
    ENST00000592780 ENST00000590612 ENST00000592360
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat ZNF225

    Additional mRNA sequence: 

    AF027138.1 AF187991.1 AK093750.1 AK223477.1 AK292437.1 AK302106.1 AK313301.1 BC108912.2 

    5 DOTS entries:

    DT.86846871  DT.121477024  DT.99930349  DT.100777983  DT.121477025 

    Selected AceView cDNA sequences (see all 42):

    AA507442 BU633034 AA321110 AA455064 N53708 AI954443 CR615158 AA455989 
    BE695021 BX349323 AI497743 BE695043 AA746283 AA456037 BX401927 BQ373099 
    BX470675 BQ373092 BM924872 BG058494 BX401928 NM_013362 AF187991 AL701679 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF225 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGTATGTAT
    ZNF225 Expression
    About this image

    ZNF225 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF225 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.279567
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and chimp.

    Orthologs for ZNF225 gene from Selected species (see all 2)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chimpanzee
    (Pan troglodytes)
    Mammalia ZNF2251 zinc finger protein 225 99.48(n)
    99.15(a)
      743641  XM_003953518.1  XP_003953567.1 


    ENSEMBL Gene Tree for ZNF225 (if available)
    TreeFam Gene Tree for ZNF225 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF225 gene
    ZNF2292  ZNF2232  ZNF2302  ZNF1552  ZNF2272  ZNF2242  ZNF2342  ZNF2262  
    ZNF2142  ZNF2222  ZNF2842  ENSG000002671732  ZNF452  ZNF2352  ZNF2212  ZNF2852  
    ENSG000002670222  ZNF1122  ZNF2332  
    Selected SIMAP similar genes for ZNF225 using alignment to 4 protein entries:     ZN225_HUMAN (see all proteins) (see all similar genes):
    ZNF224    ZNF155    ZNF234    ZNF221    ZNF230    ZNF222
    ZNF223    ZNF169    ZNF78L1    ZNF229    ZNF124    ZNF705A
    ZNF226    ZNF577    ZNF233    ZNF235    ZNF677    ZNF763

    Find genes that share paralogs with ZNF225           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF225 (see all 428)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1847608551,2
    --44619373(+) ATATCA/GTAGAA 1 -- int10--------
    rs1410303271,2
    --44619390(+) CATTTC/TGTGTG 1 -- int10--------
    rs752371871,2
    C--44619391(+) ATTTCG/ATGTGT 1 -- int12Minor allele frequency- A:0.19CSA WA 120
    rs1879753031,2
    --44619407(+) TTAATA/GATTTT 1 -- int10--------
    rs1167761961,2
    C,F--44619512(+) CCTCTT/CTGTCA 1 -- int11Minor allele frequency- C:0.02WA 118
    rs72521081,2
    C,F,A,H--44619542(+) acctaC/Tctact 1 -- int117Minor allele frequency- T:0.01NS EA NA WA CSA 792
    rs797870501,2
    C,F--44619558(+) GTTATA/GTACAC 1 -- int11Minor allele frequency- G:0.11WA 118
    rs1155775281,2
    C,F--44619767(+) AGGGAG/ATTTGT 1 -- int11Minor allele frequency- A:0.11WA 118
    rs1449766141,2
    --44619772(+) GTTTGA/TTGGTG 1 -- int10--------
    rs1124670121,2
    C--44619938(+) GGACTG/ATATCA 1 -- ut512Minor allele frequency- A:0.07CSA WA 120

    HapMap Linkage Disequilibrium report for ZNF225 (44616334 - 44637255 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZNF225:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833840CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing ZNF225
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF225

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF225 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF225)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    3. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. (PubMed id 12743021)1, 2 Shannon M.... Stubbs L. (Genome Res. 2003)
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    7. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PubMed id 10737800)1 Dias Neto E....Simpson A.J.G. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    8. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (Gene 1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7768 HGNC: 13018 AceView: ZNF225 Ensembl:ENSG00000256294 euGenes: HUgn7768
    ECgene: ZNF225 H-InvDB: ZNF225

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF225 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF225 gene:
    Search GeneIP for patents involving ZNF225

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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