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Aliases for ZNF225 Gene

Aliases for ZNF225 Gene

  • Zinc Finger Protein 225 2 3 5

External Ids for ZNF225 Gene

Previous GeneCards Identifiers for ZNF225 Gene

  • GC19P045263
  • GC19P045009
  • GC19P049293
  • GC19P049309
  • GC19P044269
  • GC19P044617

Summaries for ZNF225 Gene

GeneCards Summary for ZNF225 Gene

ZNF225 (Zinc Finger Protein 225) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF229.

UniProtKB/Swiss-Prot for ZNF225 Gene

  • May be involved in transcriptional regulation.

Gene Wiki entry for ZNF225 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF225 Gene

Genomics for ZNF225 Gene

Regulatory Elements for ZNF225 Gene

Enhancers for ZNF225 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF225 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF225 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF225 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF225 Gene

44,112,076 bp from pter
44,134,816 bp from pter
22,741 bases
Plus strand

Genomic View for ZNF225 Gene

Genes around ZNF225 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF225 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF225 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF225 Gene

Proteins for ZNF225 Gene

  • Protein details for ZNF225 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 225
    Protein Accession:
    Secondary Accessions:
    • A8K8S2
    • Q53F12
    • Q9NS46
    • Q9UID8

    Protein attributes for ZNF225 Gene

    706 amino acids
    Molecular mass:
    82471 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF225 Gene

Proteomics data for ZNF225 Gene at MOPED

Post-translational modifications for ZNF225 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF225 Gene

No data available for DME Specific Peptides for ZNF225 Gene

Domains & Families for ZNF225 Gene

Gene Families for ZNF225 Gene

Protein Domains for ZNF225 Gene

Suggested Antigen Peptide Sequences for ZNF225 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 18 C2H2-type zinc fingers.
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 18 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF225: view

Function for ZNF225 Gene

Molecular function for ZNF225 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF225: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF225 Gene

Localization for ZNF225 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF225 Gene

Subcellular locations from

Jensen Localization Image for ZNF225 Gene COMPARTMENTS Subcellular localization image for ZNF225 gene
Compartment Confidence
nucleus 3

No data available for Gene Ontology (GO) - Cellular Components for ZNF225 Gene

Pathways & Interactions for ZNF225 Gene

SuperPathways for ZNF225 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF225: view

Pathways by source for ZNF225 Gene

2 Reactome pathways for ZNF225 Gene

Interacting Proteins for ZNF225 Gene

Gene Ontology (GO) - Biological Process for ZNF225 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF225: view

No data available for SIGNOR curated interactions for ZNF225 Gene

Drugs & Compounds for ZNF225 Gene

No Compound Related Data Available

Transcripts for ZNF225 Gene

Unigene Clusters for ZNF225 Gene

Zinc finger protein 225:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF225 Gene

No ASD Table

Relevant External Links for ZNF225 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF225 Gene

mRNA expression in normal human tissues for ZNF225 Gene

Protein differential expression in normal tissues from HIPED for ZNF225 Gene

This gene is overexpressed in NK cells (32.9) and Monocytes (30.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF225 Gene

SOURCE GeneReport for Unigene cluster for ZNF225 Gene Hs.279567

genes like me logo Genes that share expression patterns with ZNF225: view

Protein tissue co-expression partners for ZNF225 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF225 Gene

Orthologs for ZNF225 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF225 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF225 35
  • 99.48 (n)
  • 99.15 (a)
ZNF225 36
  • 99 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10669 37
  • 28 (a)
CG17568 37
  • 35 (a)
EG:95B7.7 37
  • 33 (a)
Kr 37
  • 48 (a)
Species with no ortholog for ZNF225:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF225 Gene

Gene Tree for ZNF225 (if available)
Gene Tree for ZNF225 (if available)

Paralogs for ZNF225 Gene

(471) SIMAP similar genes for ZNF225 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZNF225: view

Variants for ZNF225 Gene

Sequence variations from dbSNP and Humsavar for ZNF225 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs34863330 - 44,118,488(+) GCATC(A/G)ATCAC nc-transcript-variant, upstream-variant-2KB, reference, missense
rs16978738 - 44,132,649(+) AGAAA(A/T)CATCT nc-transcript-variant, reference, missense
rs7259615 -- 44,117,159(+) CTGCA(A/C)TGATC intron-variant
rs7259662 -- 44,117,325(+) agaTC(A/G)TAGAT intron-variant
rs7508762 -- 44,125,725(+) ttgtt(C/T)atatt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF225 Gene

Variant ID Type Subtype PubMed ID
nsv833840 CNV Gain 17160897

Variation tolerance for ZNF225 Gene

Residual Variation Intolerance Score: 95.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.69; 73.03% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF225 Gene

Disorders for ZNF225 Gene

Relevant External Links for ZNF225

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF225 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF225 Gene

Publications for ZNF225 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3
  4. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. (PMID: 12743021) Shannon M. … Stubbs L. (Genome Res. 2003) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for ZNF225 Gene

Sources for ZNF225 Gene