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ZNF224 Gene

protein-coding   GIFtS: 56
GCID: GC19P044598

Zinc Finger Protein 224

(Previous names: zinc finger protein 255, zinc finger protein 27)
(Previous symbols: ZNF255, ZNF27)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 2241 2     Zinc Finger Protein 2332 3
ZNF2551 2 3 5     Zinc Finger Protein KOX222 3
ZNF271 2 3 5     BMZF-22 3
Zinc Finger Protein 2551 2 3     Zinc Finger 2, Bone Marrow2
BMZF22 3 5     Zinc Finger Protein 27 (KOX 22)2
KOX222 3 5     Zinc Finger Protein ZNF2552
Zinc Finger Protein 271 3     ZNF2333
Bone Marrow Zinc Finger 22 3     

External Ids:    HGNC: 130171   Entrez Gene: 77672   Ensembl: ENSG000002676807   OMIM: 1945555   UniProtKB: Q9NZL33   

Export aliases for ZNF224 gene to outside databases

Previous GC identifers: GC19P045244 GC19P044990 GC19P049232 GC19P049290 GC19P049182 GC19P049278 GC19P041030


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF224 Gene:
ZNF224 (zinc finger protein 224) is a protein-coding gene. An important paralog of this gene is ZNF229.

UniProtKB/Swiss-Prot: ZN224_HUMAN, Q9NZL3
Function: May be involved in transcriptional regulation as a transcriptional repressor. The DEPDC1A-ZNF224 complex
may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to
transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells

Gene Wiki entry for ZNF224 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF224 gene promoter:
         C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF224 promoter sequence
   Search Chromatin IP Primers for ZNF224

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF224


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.31   HGNC cytogenetic band: 19q13.2

ZNF224 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF224 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P044598:  view genomic region     (about GC identifiers)

Start:
44,598,482 bp from pter      End:
44,612,479 bp from pter
Size:
13,998 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN224_HUMAN, Q9NZL3 (See protein sequence)
Recommended Name: Zinc finger protein 224  
Size: 707 amino acids; 82280 Da
Subunit: Interacts with WT1. Interacts with DEPDC1A
Selected PDB 3D structures from and Proteopedia for ZNF224 (see all 16):
2ELY (3D)        2ELZ (3D)        2EM0 (3D)        2EM6 (3D)        2EM7 (3D)        2EM8 (3D)    
Secondary accessions: A6NFW9 P17033 Q86V10 Q8IZC8 Q9UID9 Q9Y2P6

Explore the universe of human proteins at neXtProt for ZNF224: NX_Q9NZL3

Explore proteomics data for ZNF224 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys258, Lys342, Lys345
  • Modification sites at PhosphoSitePlus

  • See ZNF224 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_037530.2  
    ENSEMBL proteins: 
     ENSP00000465000   ENSP00000337368   ENSP00000465886   ENSP00000466961  
    Reactome Protein details: Q9NZL3

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9NZL3

    ProtoNet protein and cluster: Q9NZL3

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN224_HUMAN, Q9NZL3
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 18 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    Find genes that share domains with ZNF224           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN224_HUMAN, Q9NZL3
    Function: May be involved in transcriptional regulation as a transcriptional repressor. The DEPDC1A-ZNF224 complex
    may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to
    transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IBA--
    GO:0005515protein binding IPI--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF224           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for ZNF224:
     Decreased homologous recombina  Decreased influenza A virus in 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF224
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN224_HUMAN, Q9NZL3: Nucleus. Note=Colocalizes with DEPDC1A at the nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA--
    GO:0017053transcriptional repressor complex IDA--
    GO:0031965nuclear membrane IDA--

    Find genes that share ontologies with ZNF224           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF224 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40


    Find genes that share SuperPaths with ZNF224           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF224
        Generic Transcription Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF224
    Interactions:

        GeneGlobe Interaction Network for ZNF224

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for ZNF224 (Q9NZL33 ENSP000003373684) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRMT5O147443, ENSP000003191694I2D: score=1 STRING: ENSP00000319169
    TRIM28Q132633, ENSP000002530244I2D: score=1 STRING: ENSP00000253024
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0045892negative regulation of transcription, DNA-templated IDA--

    Find genes that share ontologies with ZNF224           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF224 (ZN224)

    1 HMDB Compound for ZNF224    About this table
    CompoundSynonyms CAS #PubMed Ids
    ZincZinc (see all 2)7440-66-6--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF224 gene: 
    NM_013398.2  

    Unigene Cluster for ZNF224:

    Zinc finger protein 224
    Hs.585869  [show with all ESTs]
    Unigene Representative Sequence: NR_033341
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000589680 ENST00000590614 ENST00000589060 ENST00000336976(uc002oyh.2)
    ENST00000586978 ENST00000589870 ENST00000591511 ENST00000591551
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      QuantiTect SYBR Green Assays in human, mouse, rat ZNF224
      QuantiFast Probe-based Assays in human, mouse, rat ZNF224

    Additional mRNA sequence: 

    AY148489.1 BC044807.1 BC047357.1 NR_033341.1 X52353.1 

    3 DOTS entries:

    DT.100777983  DT.106576  DT.121451866 

    Selected AceView cDNA sequences (see all 63):

    H38307 AA554187 BG211495 AA830099 AI811616 AY148489 AA329390 CD000500 
    BX486591 BM769884 BM769217 BC051902 BM804721 AL135725 BQ676847 BM718961 
    BM723969 BU171224 BX099636 NM_013398 AL705386 AF187990 R72271 BU633983 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF224 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGGAGAAAA
    ZNF224 Expression
    About this image

    ZNF224 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF224 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.585869

    UniProtKB/Swiss-Prot: ZN224_HUMAN, Q9NZL3
    Tissue specificity: Ubiquitous. Mainly expressed in fetal tissues

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and chimp.

    Orthologs for ZNF224 gene from Selected species (see all 2)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chimpanzee
    (Pan troglodytes)
    Mammalia ZNF2241 zinc finger protein 224 99.58(n)
    99.58(a)
      100610569  XM_003339323.1  XP_003339371.1 


    ENSEMBL Gene Tree for ZNF224 (if available)
    TreeFam Gene Tree for ZNF224 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF224 gene
    ZNF2292  ZNF2232  ZNF2302  ZNF1552  ZNF2272  ZNF2342  ZNF2252  ZNF2262  
    ZNF2142  ZNF2222  ZNF2842  ENSG000002671732  ZNF452  ZNF2352  ZNF2212  ZNF2852  
    ENSG000002670222  ZNF1122  ZNF2332  
    Selected SIMAP similar genes for ZNF224 using alignment to 6 protein entries:     ZN224_HUMAN (see all proteins) (see all similar genes):
    ZNF225    ZNF155    ZNF221    ZNF234    AVGR4    ZNF230
    ZNF222    ZNF223    WT1    ZNF763    ZNF705G    ZNF233
    ZNF226    ZNF596    ZNF625-ZNF20    ZNF705B    ZNF705F    ZNF229

    Find genes that share paralogs with ZNF224           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF224 (see all 245)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1158563731,2
    F--44596534(+) CACAAC/TGCAGG 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs735582861,2
    C,F--44596535(+) ACAACG/TCAGGG 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1478577921,2
    --44596563(+) TATACA/GCACAC 1 -- us2k10--------
    rs764135521,2
    C,F--44596585(+) TACATA/CTATAT 1 -- us2k11Minor allele frequency- C:0.09EA 120
    rs1879682601,2
    --44596613(+) ACAAAA/GTAAGT 1 -- us2k10--------
    rs778429351,2
    C,F--44596690(+) TTGCTG/ATGGAA 1 -- us2k12Minor allele frequency- A:0.04WA 120
    rs133450601,2
    C,F--44596704(+) tgtttC/Tgtggt 1 -- us2k15Minor allele frequency- T:0.21NA WA CSA 126
    rs1922138611,2
    --44596779(+) GAAAGG/TAGGTG 1 -- us2k10--------
    rs724807951,2
    C,F--44596804(+) TGTACA/GCCACT 1 -- us2k12Minor allele frequency- G:0.12NA EA 240
    rs1153220721,2
    C,F--44596867(+) CCCTCA/GATCAA 1 -- us2k11Minor allele frequency- G:0.02WA 118

    HapMap Linkage Disequilibrium report for ZNF224 (44598482 - 44612479 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZNF224:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833840CNV Gain17160897

    Human Gene Mutation Database (HGMD): ZNF224
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF224
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF224

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 194555    OMIM disorders: --


    Find genes that share disorders with ZNF224           About GenesLikeMe

    Genetic Association Database (GAD): ZNF224
    Human Genome Epidemiology (HuGE) Navigator: ZNF224 (3 documents)

    Export disorders for ZNF224 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF224 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with ZNF224)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. Intermediate phenotypes identify divergent pathways to Alzheimer's disease. (PubMed id 20574532)1, 4 Shulman J.M....De Jager P.L. (PLoS ONE 2010)
    3. Cell-permeable peptide DEPDC1-ZNF224 interferes with transcriptional repression and oncogenicity in bladder cancer cells. (PubMed id 20587513)1, 2 Harada Y.... Katagiri T. (Cancer Res. 2010)
    4. Genome-wide association study implicates a chromosome 12 risk locus for late-onset Alzheimer disease. (PubMed id 19118814)1, 4 Beecham G.W....Pericak-Vance M.A. (Am. J. Hum. Genet. 2009)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. (PubMed id 12743021)1, 2 Shannon M.... Stubbs L. (Genome Res. 2003)
    7. Inhibition of Wilms tumor 1 transactivation by bone marrow zinc finger 2, a novel transcriptional repressor. (PubMed id 12239212)1, 2 Lee T.H.... Pelletier J. (J. Biol. Chem. 2002)
    8. Molecular cloning of six novel Kruppel-like zinc finger genes from hematopoietic cells and identification of a novel transregulatory domain KRNB. (PubMed id 10585455)1, 2 Han Z.-G.... Chen Z. (J. Biol. Chem. 1999)
    9. Multiple genes encoding zinc finger domains are expressed in human T cells. (PubMed id 2288909)1, 2 Thiesen H.-J. (New Biol. 1990)
    10. Differential expression and cellular localization of ZNF224 and ZNF255, two isoforms of the KrA1ppel-like zinc-finger protein family. (PubMed id 17900823)1, 9 Medugno L....Costanzo P. (Gene 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7767 HGNC: 13017 AceView: ZNF224 Ensembl:ENSG00000267680 euGenes: HUgn7767
    ECgene: ZNF224 H-InvDB: ZNF224

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF224 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF224 gene:
    Search GeneIP for patents involving ZNF224

    GeneCards and IP:
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