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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF224 Gene

protein-coding   GIFtS: 56
GCID: GC19P044598

Zinc Finger Protein 224

(Previous names: zinc finger protein 255, zinc finger protein 27)
(Previous symbols: ZNF255, ZNF27)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 2241 2     Zinc Finger Protein 2332 3
ZNF2551 2 3 5     Zinc Finger Protein KOX222 3
ZNF271 2 3 5     BMZF-22 3
Zinc Finger Protein 2551 2 3     Zinc Finger 2, Bone Marrow2
BMZF22 3 5     Zinc Finger Protein 27 (KOX 22)2
KOX222 3 5     Zinc Finger Protein ZNF2552
Zinc Finger Protein 271 3     ZNF2333
Bone Marrow Zinc Finger 22 3     

External Ids:    HGNC: 130171   Entrez Gene: 77672   Ensembl: ENSG000002676807   OMIM: 1945555   UniProtKB: Q9NZL33   

Export aliases for ZNF224 gene to outside databases

Previous GC identifers: GC19P045244 GC19P044990 GC19P049232 GC19P049290 GC19P049182 GC19P049278 GC19P041030


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF224 Gene: 
ZNF224 (zinc finger protein 224) is a protein-coding gene. Diseases associated with ZNF224 include wilms tumor, and alzheimer's disease, and among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF229.

UniProtKB/Swiss-Prot: ZN224_HUMAN, Q9NZL3
Function: May be involved in transcriptional regulation as a transcriptional repressor. The DEPDC1A-ZNF224 complex
may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to
transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells

Gene Wiki entry for ZNF224 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF224 gene promoter:
         C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF224 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF224

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF224


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.31   HGNC cytogenetic band: 19q13.2

ZNF224 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF224 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P044598:  view genomic region     (about GC identifiers)

Start:
44,598,482 bp from pter      End:
44,612,479 bp from pter
Size:
13,998 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN224_HUMAN, Q9NZL3 (See protein sequence)
Recommended Name: Zinc finger protein 224  
Size: 707 amino acids; 82280 Da
Subunit: Interacts with WT1. Interacts with DEPDC1A
Subcellular location: Nucleus. Note=Co-localizes with DEPDC1A at the nucleus
6/16 PDB 3D structures from and Proteopedia for ZNF224 (see all 16):
2ELY (3D)        2ELZ (3D)        2EM0 (3D)        2EM6 (3D)        2EM7 (3D)        2EM8 (3D)    
Secondary accessions: A6NFW9 P17033 Q86V10 Q8IZC8 Q9UID9 Q9Y2P6

Explore the universe of human proteins at neXtProt for ZNF224: NX_Q9NZL3

Explore proteomics data for ZNF224 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NZL3

  • ZNF224 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF224 Protein Expression
    REFSEQ proteins: NP_037530.2  
    ENSEMBL proteins: 
     ENSP00000465000   ENSP00000337368   ENSP00000465886   ENSP00000466961  
    Reactome Protein details: Q9NZL3
    Human Recombinant Protein Products for ZNF224: 
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    Novus Biologicals ZNF224 Protein
    Novus Biologicals ZNF224 Lysate
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZNF224 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA--
    GO:0017053transcriptional repressor complex IDA--

    ZNF224 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9NZL3

    ProtoNet protein and cluster: Q9NZL3

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN224_HUMAN, Q9NZL3
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 18 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF224 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN224_HUMAN, Q9NZL3
    Function: May be involved in transcriptional regulation as a transcriptional repressor. The DEPDC1A-ZNF224 complex
    may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to
    transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF224 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ZNF224:
     Decreased homologous recombina  Decreased influenza A virus in 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF224 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF224
        Generic Transcription Pathway
    Gene Expression



    ZNF224 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZNF224

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for ZNF224 (Q9NZL33 ENSP000003373684) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRMT5O147443, ENSP000003191694I2D: score=1 STRING: ENSP00000319169
    TRIM28Q132633, ENSP000002530244I2D: score=1 STRING: ENSP00000253024
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0045892negative regulation of transcription, DNA-dependent IDA--

    ZNF224 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF224 (ZN224)

    1 HMDB Compound for ZNF224    About this table
    CompoundSynonyms CAS #PubMed Ids
    ZincZinc (see all 2)7440-66-6--

    Search CenterWatch for drugs/clinical trials and news about ZNF224 / ZN224

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF224 gene: 
    NM_013398.2  

    Unigene Clusters for ZNF224:

    Zinc finger protein 224
    Hs.585869  [show with all ESTs], Hs.744152  [show with all ESTs]
    Unigene Representative Sequences: NR_033341, AK292500
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000589680 ENST00000590614 ENST00000589060 ENST00000336976(uc002oyh.2)
    ENST00000586978 ENST00000589870 ENST00000591511 ENST00000591551

    miRNA
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF224

    Additional mRNA sequence: 

    AF187990.2 AK025777.1 AK292500.1 BC051902.1 

    7 DOTS entries:

    DT.100777983  DT.106576  DT.105246  DT.100019594  DT.40123435  DT.121451866  DT.97837730 

    24/63 AceView cDNA sequences (see all 63):

    H38307 AA554187 AI811616 AY148489 BU633983 AF187990 AL705386 CD000500 
    BM818277 AA323602 BX099636 AA830099 AI689343 AA836399 BM804721 BM718961 
    T31046 BM769884 BU171224 AI806080 AW768366 R72271 BX486591 BQ676847 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF224 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGGAGAAAA
    ZNF224 Expression
    About this image


    See ZNF224 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF224

    SOURCE GeneReport for Unigene clusters: Hs.585869 Hs.744152

    UniProtKB/Swiss-Prot: ZN224_HUMAN, Q9NZL3
    Tissue specificity: Ubiquitous. Mainly expressed in fetal tissues

        SABiosciences Custom PCR Arrays for ZNF224
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ZNF224 gene from 4/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia --
    --
    63(a)
    1 → many
    1(111181194-111200966)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 4)
    --
    50(a)
    41(a)
    (see all 4)
    1 ↔ many
    possible ortholog
    (see all 4)
    GL343884.1(112712-114268)
    AAWZ02037965(878-9727)
    zebrafish
    (Danio rerio)
    Actinopterygii CT990567.26
    CABZ01070854.16
    (see all 9)
    Uncharacterized protein
    (see all 9)
    50(a)
    44(a)
    (see all 9)
    many ↔ many
    many ↔ many
    (see all 9)
    4(48926599-48927610)
    Zv9_NA787(91847-94610)
    fruit fly
    (Drosophila melanogaster)
    Insecta EG:95B7.73   -- 34(a)   3B4   --


    ENSEMBL Gene Tree for ZNF224 (if available)
    TreeFam Gene Tree for ZNF224 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF224 gene
    ZNF2292  ZNF2232  ZNF2302  ENSG000000623702  ZNF1552  ZNF2272  ZNF2252  ZNF2262  
    ZNF2142  ZNF2222  ZNF2842  ENSG000002671732  ZNF452  ZNF2352  ZNF2212  ZNF2852  
    ENSG000002670222  ZNF2332  
    18/532 SIMAP similar genes for ZNF224 using alignment to 6 protein entries:     ZN224_HUMAN (see all proteins) (see all similar genes):
    ZNF225    ZNF155    ZNF221    ZNF234    AVGR4    ZNF230
    ZNF222    ZNF223    WT1    ZNF763    ZNF705G    ZNF233
    ZNF559    ZNF226    ZNF596    ZNF705B    ZNF705F    ZNF229

    ZNF224 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/245 SNPs in ZNF224 are shown (see all 245)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0470634
    ----see VAR_0470632 H D mis40--------
    VAR_0470624
    ----see VAR_0470622 K N mis40--------
    VAR_0619414
    ----see VAR_0619412 Q H mis40--------
    VAR_0242044
    ----see VAR_0242042 H L mis40--------
    VAR_0218914
    ----see VAR_0218912 K E mis40--------
    VAR_0470614
    ----see VAR_0470612 M V mis40--------
    rs1158563731,2
    F--44596534(+) CACAAC/TGCAGG 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs735582861,2
    C,F--44596535(+) ACAACG/TCAGGG 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1478577921,2
    --44596563(+) TATACA/GCACAC 1 -- us2k10--------
    rs764135521,2
    C,F--44596585(+) TACATA/CTATAT 1 -- us2k11Minor allele frequency- C:0.09EA 120

    HapMap Linkage Disequilibrium report for ZNF224 (44598482 - 44612479 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZNF224:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833840CNV Gain17160897


    Human Gene Mutation Database (HGMD): ZNF224
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 194555    OMIM disorders: --

    2 diseases for ZNF224:    About MalaCards
    wilms tumor    alzheimer's disease


    ZNF224 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): ZNF224
    Human Genome Epidemiology (HuGE) Navigator: ZNF224 (3 documents)

    Export disorders for ZNF224 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF224 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with ZNF224)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    2. Intermediate phenotypes identify divergent pathways t o Alzheimer's disease. (PubMed id 20574532)1, 4 Shulman J.M....De Jager P.L. (2010)
    3. Cell-permeable peptide DEPDC1-ZNF224 interferes with transcriptional repression and oncogenicity in bladder cancer cells. (PubMed id 20587513)1, 2 Harada Y....Katagiri T. (2010)
    4. Genome-wide association study implicates a chromosome 12 risk locus for late-onset Alzheimer disease. (PubMed id 19118814)1, 4 Beecham G.W....Pericak-Vance M.A. (2009)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. (PubMed id 12743021)1, 2 Shannon M.... Stubbs L. (2003)
    7. Inhibition of Wilms tumor 1 transactivation by bone marrow zinc finger 2, a novel transcriptional repressor. (PubMed id 12239212)1, 2 Lee T.H.... Pelletier J. (2002)
    8. Molecular cloning of six novel Kruppel-like zinc finger genes from hematopoietic cells and identification of a novel transregulatory domain KRNB. (PubMed id 10585455)1, 2 Han Z.-G.... Chen Z. (1999)
    9. Multiple genes encoding zinc finger domains are expressed in human T cells. (PubMed id 2288909)1, 2 Thiesen H.-J. (1990)
    10. Differential expression and cellular localization of ZNF224 and ZNF255, two isoforms of the Kruppel-like zinc-finger protein family. (PubMed id 17900823)1, 9 Medugno L....Costanzo P. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7767 HGNC: 13017 AceView: ZNF224 Ensembl:ENSG00000267680 euGenes: HUgn7767
    ECgene: ZNF224 H-InvDB: ZNF224

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    About This Section
    NameDescription
    PharmGKB entry for ZNF224 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for ZNF224 gene:
    Search GeneIP for patents involving ZNF224

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