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Aliases for ZNF224 Gene

Aliases for ZNF224 Gene

  • Zinc Finger Protein 224 2 3
  • Zinc Finger Protein 255 2 3 4
  • ZNF255 3 4 6
  • ZNF27 3 4 6
  • BMZF2 3 4 6
  • KOX22 3 4 6
  • Bone Marrow Zinc Finger 2 3 4
  • Zinc Finger Protein KOX22 3 4
  • Zinc Finger Protein 233 3 4
  • Zinc Finger Protein 27 2 4
  • BMZF-2 3 4
  • Zinc Finger Protein 27 (KOX 22) 3
  • Zinc Finger 2, Bone Marrow 3
  • Zinc Finger Protein ZNF255 3
  • ZNF233 4

External Ids for ZNF224 Gene

Previous Symbols for ZNF224 Gene

  • ZNF255
  • ZNF27

Summaries for ZNF224 Gene

GeneCards Summary for ZNF224 Gene

ZNF224 (Zinc Finger Protein 224) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF155.

UniProtKB/Swiss-Prot for ZNF224 Gene

  • May be involved in transcriptional regulation as a transcriptional repressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells.

Gene Wiki entry for ZNF224 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF224 Gene

Genomics for ZNF224 Gene

Genomic Location for ZNF224 Gene

Start:
44,094,329 bp from pter
End:
44,109,886 bp from pter
Size:
15,558 bases
Orientation:
Plus strand

Genomic View for ZNF224 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF224 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF224 Gene

Regulatory Elements for ZNF224 Gene

Transcription factor binding sites by QIAGEN in the ZNF224 gene promoter:

Proteins for ZNF224 Gene

  • Protein details for ZNF224 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZL3-ZN224_HUMAN
    Recommended name:
    Zinc finger protein 224
    Protein Accession:
    Q9NZL3
    Secondary Accessions:
    • A6NFW9
    • P17033
    • Q86V10
    • Q8IZC8
    • Q9UID9
    • Q9Y2P6

    Protein attributes for ZNF224 Gene

    Size:
    707 amino acids
    Molecular mass:
    82280 Da
    Quaternary structure:
    • Interacts with WT1. Interacts with DEPDC1A.

    Three dimensional structures from OCA and Proteopedia for ZNF224 Gene

neXtProt entry for ZNF224 Gene

Proteomics data for ZNF224 Gene at MOPED

Post-translational modifications for ZNF224 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys258, Lys342, and Lys345

Other Protein References for ZNF224 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF224 Gene

Domains for ZNF224 Gene

Gene Families for ZNF224 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF224 Gene

UniProtKB/Swiss-Prot:

ZN224_HUMAN
Domain:
  • Contains 1 KRAB domain.:
    • Q9NZL3
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.:
    • Q9NZL3
Similarity:
  • Contains 18 C2H2-type zinc fingers.:
    • Q9NZL3
genes like me logo Genes that share domains with ZNF224: view

Function for ZNF224 Gene

Molecular function for ZNF224 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation as a transcriptional repressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells.

Gene Ontology (GO) - Molecular Function for ZNF224 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IBA --
GO:0005515 protein binding IPI 20587513
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF224: view

Phenotypes for ZNF224 Gene

genes like me logo Genes that share phenotypes with ZNF224: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF224 Gene

Localization for ZNF224 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF224 Gene

Nucleus. Note=Colocalizes with DEPDC1A at the nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF224 Gene COMPARTMENTS Subcellular localization image for ZNF224 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF224 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0017053 transcriptional repressor complex IDA 20587513
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with ZNF224: view

Pathways for ZNF224 Gene

SuperPathways for ZNF224 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF224: view

Pathways by source for ZNF224 Gene

2 Reactome pathways for ZNF224 Gene

Gene Ontology (GO) - Biological Process for ZNF224 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0045892 negative regulation of transcription, DNA-templated IDA 20587513
genes like me logo Genes that share ontologies with ZNF224: view

Compounds for ZNF224 Gene

(1) HMDB Compounds for ZNF224 Gene

Compound Synonyms Cas Number PubMed IDs
Zinc
  • Zinc
7440-66-6
genes like me logo Genes that share compounds with ZNF224: view

Transcripts for ZNF224 Gene

Unigene Clusters for ZNF224 Gene

Zinc finger protein 224:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF224 Gene

No ASD Table

Relevant External Links for ZNF224 Gene

GeneLoc Exon Structure for
ZNF224
ECgene alternative splicing isoforms for
ZNF224

Expression for ZNF224 Gene

mRNA expression in normal human tissues for ZNF224 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZNF224 Gene

SOURCE GeneReport for Unigene cluster for ZNF224 Gene Hs.585869

mRNA Expression by UniProt/SwissProt for ZNF224 Gene

Q9NZL3-ZN224_HUMAN
Tissue specificity: Ubiquitous. Mainly expressed in fetal tissues.
genes like me logo Genes that share expressions with ZNF224: view

Orthologs for ZNF224 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF224 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF224 36
  • 99.58 (n)
  • 99.58 (a)
ZNF224 37
  • 100 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta EG:95B7.7 38
  • 34 (a)
Species with no ortholog for ZNF224:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF224 Gene

ENSEMBL:
Gene Tree for ZNF224 (if available)
TreeFam:
Gene Tree for ZNF224 (if available)

Paralogs for ZNF224 Gene

Selected SIMAP similar genes for ZNF224 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ZNF224: view

Variants for ZNF224 Gene

Sequence variations from dbSNP and Humsavar for ZNF224 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs4429390 -- 44,094,715(+) TCTTC(G/T)CGATA intron-variant
rs4459653 -- 44,095,462(+) TGTCA(C/T)TGAGG intron-variant
rs4802204 -- 44,093,142(+) tcacg(A/C)ctgta upstream-variant-2KB
rs4802205 -- 44,093,276(+) cacgc(A/G)cctgt upstream-variant-2KB
rs4802206 -- 44,096,083(+) TTCCC(C/T)CTTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF224 Gene

Variant ID Type Subtype PubMed ID
nsv833840 CNV Gain 17160897

Relevant External Links for ZNF224 Gene

HapMap Linkage Disequilibrium report
ZNF224
Human Gene Mutation Database (HGMD)
ZNF224

Disorders for ZNF224 Gene

Relevant External Links for ZNF224

Genetic Association Database (GAD)
ZNF224
Human Genome Epidemiology (HuGE) Navigator
ZNF224
genes like me logo Genes that share disorders with ZNF224: view

No data available for UniProtKB/Swiss-Prot for ZNF224 Gene

Publications for ZNF224 Gene

  1. Differential expression and cellular localization of ZNF224 and ZNF255, two isoforms of the KrA1ppel-like zinc-finger protein family. (PMID: 17900823) Medugno L. … Costanzo P. (Gene 2007) 3 23
  2. Multiple genes encoding zinc finger domains are expressed in human T cells. (PMID: 2288909) Thiesen H.-J. (New Biol. 1990) 3 4
  3. Molecular cloning of six novel Kruppel-like zinc finger genes from hematopoietic cells and identification of a novel transregulatory domain KRNB. (PMID: 10585455) Han Z.-G. … Chen Z. (J. Biol. Chem. 1999) 3 4
  4. Inhibition of Wilms tumor 1 transactivation by bone marrow zinc finger 2, a novel transcriptional repressor. (PMID: 12239212) Lee T.H. … Pelletier J. (J. Biol. Chem. 2002) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ZNF224 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ZNF224
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF224
    • Block miRNA regulation of ZNF224 using miScript Target Protectors

    Sources for ZNF224 Gene

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