Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF224 Gene

Aliases for ZNF224 Gene

  • Zinc Finger Protein 224 2 3 5
  • Zinc Finger Protein 255 2 3 4
  • Zinc Finger Protein 27 2 3 4
  • Bone Marrow Zinc Finger 2 3 4
  • Zinc Finger Protein KOX22 3 4
  • Zinc Finger Protein 233 3 4
  • ZNF255 3 4
  • BMZF-2 3 4
  • ZNF233 3 4
  • ZNF27 3 4
  • BMZF2 3 4
  • KOX22 3 4

External Ids for ZNF224 Gene

Previous HGNC Symbols for ZNF224 Gene

  • ZNF255
  • ZNF27

Previous GeneCards Identifiers for ZNF224 Gene

  • GC19P045244
  • GC19P044990
  • GC19P049232
  • GC19P049290
  • GC19P049182
  • GC19P049278
  • GC19P044598
  • GC19P041030

Summaries for ZNF224 Gene

Entrez Gene Summary for ZNF224 Gene

  • This gene encodes a member of the Krueppel C2H2-type zinc-finger family of proteins. The encoded protein represses transcription of the aldolase A gene, which encodes a key enzyme in glycolysis. The encoded zinc-finger protein may also function as a transcriptional co-activator with Wilms' tumor protein 1 to regulate apoptotic genes in leukemia. [provided by RefSeq, Jul 2016]

GeneCards Summary for ZNF224 Gene

ZNF224 (Zinc Finger Protein 224) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF225.

UniProtKB/Swiss-Prot for ZNF224 Gene

  • May be involved in transcriptional regulation as a transcriptional repressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells.

Gene Wiki entry for ZNF224 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF224 Gene

Genomics for ZNF224 Gene

Regulatory Elements for ZNF224 Gene

Enhancers for ZNF224 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F043200 0.5 Ensembl ENCODE 108.8 -891.1 -891130 6.2 ZNF493 ZFP64 ARID4B DMAP1 FEZF1 GLI4 ZNF48 ZNF121 ZNF302 ZNF416 ZNF45 ZNF224 ZNF225 ZNF526 ZNF234 ZNF284 PSG4 XRCC1 ZNF230 IRGQ
GH19F043901 1.1 ENCODE 87.4 -192.5 -192477 1.2 CREB3L1 ARID4B ZNF2 YY1 ZNF302 ZNF416 ZNF143 ZNF548 ZNF263 SP3 ZNF45 ZNF180 ZNF224 ZNF234 ZNF284 ZNF225 ZNF230 ZNF404 XRCC1 LOC105372414
GH19F044164 1.1 ENCODE 86.5 +70.9 70921 1.8 PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF302 ZNF180 ZNF45 ZNF155 ZNF234 ZNF224 ZNF284 ZNF225 XRCC1 ZNF230 NECTIN2
GH19F044259 0.9 ENCODE 79.2 +165.7 165704 1.4 HDGF PKNOX1 ARID4B SIN3A YBX1 FEZF1 DMAP1 ZNF2 ZNF302 ZNF416 ZNF180 ZNF45 ZNF234 ZNF224 ZNF284 ZNF225 ZNF230 EXOC3L2 XRCC1 ZNF233
GH19F043751 1.1 FANTOM5 ENCODE 79.2 -338.5 -338453 8.9 CREB3L1 FEZF1 DMAP1 YBX1 YY1 ZNF143 ZNF416 ZNF548 ZNF263 SP3 ZNF180 ZNF45 ZNF234 ZNF224 ZNF284 ZNF225 ZNF230 XRCC1 SMG9 LOC100505715
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZNF224 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF224 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000044669 472 2399 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 ZNF302 ZNF143 SP3

Transcription factor binding sites by QIAGEN in the ZNF224 gene promoter:

Genomic Location for ZNF224 Gene

Chromosome:
19
Start:
44,094,329 bp from pter
End:
44,109,886 bp from pter
Size:
15,558 bases
Orientation:
Plus strand

Genomic View for ZNF224 Gene

Genes around ZNF224 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF224 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF224 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF224 Gene

Proteins for ZNF224 Gene

  • Protein details for ZNF224 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZL3-ZN224_HUMAN
    Recommended name:
    Zinc finger protein 224
    Protein Accession:
    Q9NZL3
    Secondary Accessions:
    • A6NFW9
    • P17033
    • Q86V10
    • Q8IZC8
    • Q9UID9
    • Q9Y2P6

    Protein attributes for ZNF224 Gene

    Size:
    707 amino acids
    Molecular mass:
    82280 Da
    Quaternary structure:
    • Interacts with WT1. Interacts with DEPDC1A.

    Three dimensional structures from OCA and Proteopedia for ZNF224 Gene

neXtProt entry for ZNF224 Gene

Post-translational modifications for ZNF224 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF224 Gene

Antibody Products

  • Abcam antibodies for ZNF224
  • Santa Cruz Biotechnology (SCBT) Antibodies for ZNF224

No data available for DME Specific Peptides for ZNF224 Gene

Domains & Families for ZNF224 Gene

Gene Families for ZNF224 Gene

Protein Domains for ZNF224 Gene

Suggested Antigen Peptide Sequences for ZNF224 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NZL3

UniProtKB/Swiss-Prot:

ZN224_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 18 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 18 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF224: view

Function for ZNF224 Gene

Molecular function for ZNF224 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation as a transcriptional repressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells.

Gene Ontology (GO) - Molecular Function for ZNF224 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0005515 protein binding IPI 20587513
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF224: view
genes like me logo Genes that share phenotypes with ZNF224: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF224 Gene

Localization for ZNF224 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF224 Gene

Nucleus. Note=Colocalizes with DEPDC1A at the nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF224 Gene COMPARTMENTS Subcellular localization image for ZNF224 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZNF224 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA,IDA 20587513
GO:0017053 transcriptional repressor complex IDA 20587513
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with ZNF224: view

Pathways & Interactions for ZNF224 Gene

SuperPathways for ZNF224 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF224: view

Pathways by source for ZNF224 Gene

2 Reactome pathways for ZNF224 Gene

Gene Ontology (GO) - Biological Process for ZNF224 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045892 negative regulation of transcription, DNA-templated IDA 20587513
genes like me logo Genes that share ontologies with ZNF224: view

No data available for SIGNOR curated interactions for ZNF224 Gene

Drugs & Compounds for ZNF224 Gene

(1) Drugs for ZNF224 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved Pharma 2231
genes like me logo Genes that share compounds with ZNF224: view

Transcripts for ZNF224 Gene

Unigene Clusters for ZNF224 Gene

Zinc finger protein 224:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF224 Gene

No ASD Table

Relevant External Links for ZNF224 Gene

GeneLoc Exon Structure for
ZNF224
ECgene alternative splicing isoforms for
ZNF224

Expression for ZNF224 Gene

mRNA expression in normal human tissues for ZNF224 Gene

Protein differential expression in normal tissues from HIPED for ZNF224 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF224 Gene



Protein tissue co-expression partners for ZNF224 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF224 Gene:

ZNF224

SOURCE GeneReport for Unigene cluster for ZNF224 Gene:

Hs.585869

mRNA Expression by UniProt/SwissProt for ZNF224 Gene:

Q9NZL3-ZN224_HUMAN
Tissue specificity: Ubiquitous. Mainly expressed in fetal tissues.
genes like me logo Genes that share expression patterns with ZNF224: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZNF224 Gene

Orthologs for ZNF224 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF224 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF224 34 35
  • 99.58 (n)
fruit fly
(Drosophila melanogaster)
Insecta EG:95B7.7 36
  • 34 (a)
Species where no ortholog for ZNF224 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF224 Gene

ENSEMBL:
Gene Tree for ZNF224 (if available)
TreeFam:
Gene Tree for ZNF224 (if available)

Paralogs for ZNF224 Gene

(535) SIMAP similar genes for ZNF224 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ZNF224: view

Variants for ZNF224 Gene

Sequence variations from dbSNP and Humsavar for ZNF224 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs193921003 Uncertain significance 44,107,514(+) ATACA(A/G)GAGAG nc-transcript-variant, reference, missense
rs10401658 -- 44,097,764(+) GGCCA(C/G)CTTTT intron-variant
rs10402073 -- 44,096,032(+) ATAGG(A/T)TTATT intron-variant, upstream-variant-2KB
rs10404791 -- 44,093,260(+) tagcc(A/G)ggcgt upstream-variant-2KB
rs10404999 -- 44,093,295(+) ctact(C/T)gggag upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNF224 Gene

Variant ID Type Subtype PubMed ID
nsv833840 CNV gain 17160897
nsv978828 CNV duplication 23825009

Variation tolerance for ZNF224 Gene

Residual Variation Intolerance Score: 69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.88; 67.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF224 Gene

Human Gene Mutation Database (HGMD)
ZNF224
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF224

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF224 Gene

Disorders for ZNF224 Gene

Relevant External Links for ZNF224

Genetic Association Database (GAD)
ZNF224
Human Genome Epidemiology (HuGE) Navigator
ZNF224
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF224

No disorders were found for ZNF224 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF224 Gene

Publications for ZNF224 Gene

  1. Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1. (PMID: 23665872) Wang W. … Huang Z. (Cell. Mol. Life Sci. 2013) 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Intermediate phenotypes identify divergent pathways to Alzheimer's disease. (PMID: 20574532) Shulman J.M. … De Jager P.L. (PLoS ONE 2010) 3 46 64
  4. Cell-permeable peptide DEPDC1-ZNF224 interferes with transcriptional repression and oncogenicity in bladder cancer cells. (PMID: 20587513) Harada Y. … Katagiri T. (Cancer Res. 2010) 3 4 64
  5. Genome-wide association study implicates a chromosome 12 risk locus for late-onset Alzheimer disease. (PMID: 19118814) Beecham G.W. … Pericak-Vance M.A. (Am. J. Hum. Genet. 2009) 3 46 64

Products for ZNF224 Gene

Sources for ZNF224 Gene

Content
Loading form....