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Aliases for ZNF224 Gene

Aliases for ZNF224 Gene

  • Zinc Finger Protein 224 2 3 5
  • Zinc Finger Protein 255 2 3 4
  • Zinc Finger Protein 27 2 3 4
  • Bone Marrow Zinc Finger 2 3 4
  • Zinc Finger Protein KOX22 3 4
  • Zinc Finger Protein 233 3 4
  • ZNF255 3 4
  • BMZF-2 3 4
  • ZNF233 3 4
  • ZNF27 3 4
  • BMZF2 3 4
  • KOX22 3 4

External Ids for ZNF224 Gene

Previous HGNC Symbols for ZNF224 Gene

  • ZNF255
  • ZNF27

Previous GeneCards Identifiers for ZNF224 Gene

  • GC19P045244
  • GC19P044990
  • GC19P049232
  • GC19P049290
  • GC19P049182
  • GC19P049278
  • GC19P044598
  • GC19P041030

Summaries for ZNF224 Gene

GeneCards Summary for ZNF224 Gene

ZNF224 (Zinc Finger Protein 224) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF229.

UniProtKB/Swiss-Prot for ZNF224 Gene

  • May be involved in transcriptional regulation as a transcriptional repressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells.

Gene Wiki entry for ZNF224 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF224 Gene

Genomics for ZNF224 Gene

Regulatory Elements for ZNF224 Gene

Promoters for ZNF224 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF224 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the ZNF224 gene promoter:

Genomic Location for ZNF224 Gene

Chromosome:
19
Start:
44,094,329 bp from pter
End:
44,109,886 bp from pter
Size:
15,558 bases
Orientation:
Plus strand

Genomic View for ZNF224 Gene

Genes around ZNF224 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF224 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF224 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF224 Gene

Proteins for ZNF224 Gene

  • Protein details for ZNF224 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZL3-ZN224_HUMAN
    Recommended name:
    Zinc finger protein 224
    Protein Accession:
    Q9NZL3
    Secondary Accessions:
    • A6NFW9
    • P17033
    • Q86V10
    • Q8IZC8
    • Q9UID9
    • Q9Y2P6

    Protein attributes for ZNF224 Gene

    Size:
    707 amino acids
    Molecular mass:
    82280 Da
    Quaternary structure:
    • Interacts with WT1. Interacts with DEPDC1A.

    Three dimensional structures from OCA and Proteopedia for ZNF224 Gene

neXtProt entry for ZNF224 Gene

Proteomics data for ZNF224 Gene at MOPED

Post-translational modifications for ZNF224 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF224 Gene

Antibody Products

No data available for DME Specific Peptides for ZNF224 Gene

Domains & Families for ZNF224 Gene

Gene Families for ZNF224 Gene

Protein Domains for ZNF224 Gene

Suggested Antigen Peptide Sequences for ZNF224 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NZL3

UniProtKB/Swiss-Prot:

ZN224_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 18 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 18 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF224: view

Function for ZNF224 Gene

Molecular function for ZNF224 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation as a transcriptional repressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells.

Gene Ontology (GO) - Molecular Function for ZNF224 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20587513
genes like me logo Genes that share ontologies with ZNF224: view
genes like me logo Genes that share phenotypes with ZNF224: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF224 Gene

Localization for ZNF224 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF224 Gene

Nucleus. Note=Colocalizes with DEPDC1A at the nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF224 Gene COMPARTMENTS Subcellular localization image for ZNF224 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZNF224 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with ZNF224: view

Pathways & Interactions for ZNF224 Gene

SuperPathways for ZNF224 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF224: view

Pathways by source for ZNF224 Gene

2 Reactome pathways for ZNF224 Gene

Gene Ontology (GO) - Biological Process for ZNF224 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045892 negative regulation of transcription, DNA-templated IDA 20587513
genes like me logo Genes that share ontologies with ZNF224: view

No data available for SIGNOR curated interactions for ZNF224 Gene

Drugs & Compounds for ZNF224 Gene

(1) Drugs for ZNF224 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved Pharma 1477
genes like me logo Genes that share compounds with ZNF224: view

Transcripts for ZNF224 Gene

Unigene Clusters for ZNF224 Gene

Zinc finger protein 224:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF224 Gene

No ASD Table

Relevant External Links for ZNF224 Gene

GeneLoc Exon Structure for
ZNF224
ECgene alternative splicing isoforms for
ZNF224

Expression for ZNF224 Gene

mRNA expression in normal human tissues for ZNF224 Gene

Protein differential expression in normal tissues from HIPED for ZNF224 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF224 Gene



SOURCE GeneReport for Unigene cluster for ZNF224 Gene Hs.585869

mRNA Expression by UniProt/SwissProt for ZNF224 Gene

Q9NZL3-ZN224_HUMAN
Tissue specificity: Ubiquitous. Mainly expressed in fetal tissues.
genes like me logo Genes that share expression patterns with ZNF224: view

Protein tissue co-expression partners for ZNF224 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZNF224 Gene

Orthologs for ZNF224 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF224 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF224 35
  • 99.58 (n)
  • 99.58 (a)
ZNF224 36
  • 100 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta EG:95B7.7 37
  • 34 (a)
Species with no ortholog for ZNF224:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF224 Gene

ENSEMBL:
Gene Tree for ZNF224 (if available)
TreeFam:
Gene Tree for ZNF224 (if available)

Paralogs for ZNF224 Gene

(535) SIMAP similar genes for ZNF224 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ZNF224: view

Variants for ZNF224 Gene

Sequence variations from dbSNP and Humsavar for ZNF224 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_021891 -
VAR_024204 -
VAR_047061 -
VAR_047062 -
VAR_047063 -

Structural Variations from Database of Genomic Variants (DGV) for ZNF224 Gene

Variant ID Type Subtype PubMed ID
nsv833840 CNV Gain 17160897

Variation tolerance for ZNF224 Gene

Residual Variation Intolerance Score: 69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.88; 67.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF224 Gene

HapMap Linkage Disequilibrium report
ZNF224
Human Gene Mutation Database (HGMD)
ZNF224

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF224 Gene

Disorders for ZNF224 Gene

Relevant External Links for ZNF224

Genetic Association Database (GAD)
ZNF224
Human Genome Epidemiology (HuGE) Navigator
ZNF224
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF224

No disorders were found for ZNF224 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF224 Gene

Publications for ZNF224 Gene

  1. Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1. (PMID: 23665872) Wang W. … Huang Z. (Cell. Mol. Life Sci. 2013) 3 4 67
  2. Differential expression and cellular localization of ZNF224 and ZNF255, two isoforms of the KrA1ppel-like zinc-finger protein family. (PMID: 17900823) Medugno L. … Costanzo P. (Gene 2007) 3 23
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Role of WT1-ZNF224 interaction in the expression of apoptosis-regulating genes. (PMID: 23362234) Montano G. … Costanzo P. (Hum. Mol. Genet. 2013) 3

Products for ZNF224 Gene

Sources for ZNF224 Gene

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