Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF223 Gene

Aliases for ZNF223 Gene

  • Zinc Finger Protein 223 2 3

External Ids for ZNF223 Gene

Previous GeneCards Identifiers for ZNF223 Gene

  • GC19U990143
  • GC19P044940
  • GC19P049224
  • GC19P049240
  • GC19P049248
  • GC19P044556
  • GC19P040988
  • GC19P044555

Summaries for ZNF223 Gene

Entrez Gene Summary for ZNF223 Gene

  • This gene encodes a protein containing a Kruppel-associated box domain and multiple zinc finger domains. The function of this protein has yet to be determined. [provided by RefSeq, Mar 2014]

GeneCards Summary for ZNF223 Gene

ZNF223 (Zinc Finger Protein 223) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF155.

UniProtKB/Swiss-Prot for ZNF223 Gene

  • May be involved in transcriptional regulation

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF223 Gene

Genomics for ZNF223 Gene

Regulatory Elements for ZNF223 Gene

Transcription factor binding sites by QIAGEN in the ZNF223 gene promoter:

Genomic Location for ZNF223 Gene

Start:
44,051,367 bp from pter
End:
44,067,991 bp from pter
Size:
16,625 bases
Orientation:
Plus strand

Genomic View for ZNF223 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF223 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF223 Gene

Proteins for ZNF223 Gene

  • Protein details for ZNF223 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UK11-ZN223_HUMAN
    Recommended name:
    Zinc finger protein 223
    Protein Accession:
    Q9UK11
    Secondary Accessions:
    • Q15736
    • Q8TBJ3
    • Q9HCA9

    Protein attributes for ZNF223 Gene

    Size:
    482 amino acids
    Molecular mass:
    55763 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB03531.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for ZNF223 Gene

Proteomics data for ZNF223 Gene at MOPED

Post-translational modifications for ZNF223 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF223 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF223 Gene

Domains for ZNF223 Gene

Gene Families for ZNF223 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF223 Gene

Suggested Antigen Peptide Sequences for ZNF223 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UK11

UniProtKB/Swiss-Prot:

ZN223_HUMAN :
  • Q9UK11
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 10 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF223: view

Function for ZNF223 Gene

Molecular function for ZNF223 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF223 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding NAS 10449920
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF223: view

Phenotypes for ZNF223 Gene

genes like me logo Genes that share phenotypes with ZNF223: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF223

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF223 Gene

Localization for ZNF223 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF223 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF223 Gene COMPARTMENTS Subcellular localization image for ZNF223 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF223 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF223: view

Pathways for ZNF223 Gene

SuperPathways for ZNF223 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF223: view

Pathways by source for ZNF223 Gene

2 Reactome pathways for ZNF223 Gene

Gene Ontology (GO) - Biological Process for ZNF223 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ZNF223: view

Transcripts for ZNF223 Gene

mRNA/cDNA for ZNF223 Gene

Unigene Clusters for ZNF223 Gene

Zinc finger protein 223:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF223

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF223 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b
SP1: - - -
SP2: -
SP3:
SP4: - - - -
SP5:

Relevant External Links for ZNF223 Gene

GeneLoc Exon Structure for
ZNF223
ECgene alternative splicing isoforms for
ZNF223

Expression for ZNF223 Gene

mRNA expression in normal human tissues for ZNF223 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZNF223 Gene

SOURCE GeneReport for Unigene cluster for ZNF223 Gene Hs.720813

genes like me logo Genes that share expressions with ZNF223: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF223 Gene

Orthologs for ZNF223 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for ZNF223 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 99 (a)
OneToMany
ZNF223 35
  • 99.37 (n)
  • 98.95 (a)
Species with no ortholog for ZNF223:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF223 Gene

ENSEMBL:
Gene Tree for ZNF223 (if available)
TreeFam:
Gene Tree for ZNF223 (if available)

Paralogs for ZNF223 Gene

Selected SIMAP similar genes for ZNF223 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZNF223: view

Variants for ZNF223 Gene

Sequence variations from dbSNP and Humsavar for ZNF223 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs3810406 -- 44,052,228(+) TTCCC(G/T)TCAGC intron-variant, upstream-variant-2KB
rs3826941 -- 44,060,828(+) CAAAG(A/G)GAAGG synonymous-codon, reference
rs4130100 -- 44,060,564(+) CTTCA(A/G)GAACC missense, reference
rs4130101 - 44,060,784(+) ACTTT(A/C)TAAGG missense, reference
rs4239528 -- 44,058,775(+) tgcct(A/G)tggca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF223 Gene

Variant ID Type Subtype PubMed ID
nsv833840 CNV Gain 17160897

Relevant External Links for ZNF223 Gene

HapMap Linkage Disequilibrium report
ZNF223

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF223 Gene

Disorders for ZNF223 Gene

No disorders were found for ZNF223 Gene.

No data available for UniProtKB/Swiss-Prot for ZNF223 Gene

Publications for ZNF223 Gene

  1. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. (PMID: 12743021) Shannon M. … Stubbs L. (Genome Res. 2003) 3 4
  2. Comparative analysis of a conserved zinc finger gene cluster on human chromosome 19q and mouse chromosome 7. (PMID: 8617494) Shannon M. … Stubbs L. (Genomics 1996) 3 4
  3. Coding region intron/exon organization, alternative splicing and X- chromosome inactivation of the KRAB/FPB-domain-containing human zinc finger gene ZNF41. (PMID: 10449920) Rosati M. … Grimaldi G. (Cytogenet. Cell Genet. 1999) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3

Products for ZNF223 Gene

Sources for ZNF223 Gene

Back to Top

Content