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Aliases for ZNF223 Gene

Aliases for ZNF223 Gene

  • Zinc Finger Protein 223 2 3 5

External Ids for ZNF223 Gene

Previous GeneCards Identifiers for ZNF223 Gene

  • GC19U990143
  • GC19P044940
  • GC19P049224
  • GC19P049240
  • GC19P049248
  • GC19P044556
  • GC19P040988
  • GC19P044555

Summaries for ZNF223 Gene

Entrez Gene Summary for ZNF223 Gene

  • This gene encodes a protein containing a Kruppel-associated box domain and multiple zinc finger domains. The function of this protein has yet to be determined. [provided by RefSeq, Mar 2014]

GeneCards Summary for ZNF223 Gene

ZNF223 (Zinc Finger Protein 223) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF229.

UniProtKB/Swiss-Prot for ZNF223 Gene

  • May be involved in transcriptional regulation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF223 Gene

Genomics for ZNF223 Gene

Regulatory Elements for ZNF223 Gene

Enhancers for ZNF223 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF223 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF223 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF223 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the ZNF223 gene promoter:

Genomic Location for ZNF223 Gene

Chromosome:
19
Start:
44,051,367 bp from pter
End:
44,067,994 bp from pter
Size:
16,628 bases
Orientation:
Plus strand

Genomic View for ZNF223 Gene

Genes around ZNF223 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF223 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF223 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF223 Gene

Proteins for ZNF223 Gene

  • Protein details for ZNF223 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UK11-ZN223_HUMAN
    Recommended name:
    Zinc finger protein 223
    Protein Accession:
    Q9UK11
    Secondary Accessions:
    • Q15736
    • Q8TBJ3
    • Q9HCA9

    Protein attributes for ZNF223 Gene

    Size:
    482 amino acids
    Molecular mass:
    55763 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB03531.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for ZNF223 Gene

Proteomics data for ZNF223 Gene at MOPED

Post-translational modifications for ZNF223 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF223 Gene

Antibody Products

No data available for DME Specific Peptides for ZNF223 Gene

Domains & Families for ZNF223 Gene

Gene Families for ZNF223 Gene

Protein Domains for ZNF223 Gene

Suggested Antigen Peptide Sequences for ZNF223 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UK11

UniProtKB/Swiss-Prot:

ZN223_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 10 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 10 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF223: view

Function for ZNF223 Gene

Molecular function for ZNF223 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF223: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF223 Gene

Localization for ZNF223 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF223 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF223 Gene COMPARTMENTS Subcellular localization image for ZNF223 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF223 Gene

Pathways & Interactions for ZNF223 Gene

SuperPathways for ZNF223 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF223: view

Pathways by source for ZNF223 Gene

2 Reactome pathways for ZNF223 Gene

Gene Ontology (GO) - Biological Process for ZNF223 Gene

None

No data available for SIGNOR curated interactions for ZNF223 Gene

Drugs & Compounds for ZNF223 Gene

No Compound Related Data Available

Transcripts for ZNF223 Gene

Unigene Clusters for ZNF223 Gene

Zinc finger protein 223:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF223 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b
SP1: - - -
SP2: -
SP3:
SP4: - - - -
SP5:

Relevant External Links for ZNF223 Gene

GeneLoc Exon Structure for
ZNF223
ECgene alternative splicing isoforms for
ZNF223

Expression for ZNF223 Gene

mRNA expression in normal human tissues for ZNF223 Gene

Protein differential expression in normal tissues from HIPED for ZNF223 Gene

This gene is overexpressed in Heart (34.7) and Monocytes (34.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF223 Gene



SOURCE GeneReport for Unigene cluster for ZNF223 Gene Hs.720813

genes like me logo Genes that share expression patterns with ZNF223: view

Protein tissue co-expression partners for ZNF223 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF223 Gene

Orthologs for ZNF223 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for ZNF223 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF223 35
  • 99.37 (n)
  • 98.95 (a)
-- 36
  • 99 (a)
OneToMany
Species with no ortholog for ZNF223:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF223 Gene

ENSEMBL:
Gene Tree for ZNF223 (if available)
TreeFam:
Gene Tree for ZNF223 (if available)

Paralogs for ZNF223 Gene

(511) SIMAP similar genes for ZNF223 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZNF223: view

Variants for ZNF223 Gene

Sequence variations from dbSNP and Humsavar for ZNF223 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_060424 -
rs6509138 - 44,066,240(+) AAGGA(A/C)TATCT reference, missense
rs7260075 -- 44,062,613(+) TGCAG(C/T)TGACC intron-variant
rs7260087 -- 44,057,135(+) GAATT(A/G)TTCTT intron-variant
rs12979522 -- 44,051,510(+) TGTCC(A/T)AGAAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNF223 Gene

Variant ID Type Subtype PubMed ID
nsv833840 CNV Gain 17160897

Variation tolerance for ZNF223 Gene

Residual Variation Intolerance Score: 61.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.02; 50.08% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF223 Gene

Disorders for ZNF223 Gene

Relevant External Links for ZNF223

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF223

No disorders were found for ZNF223 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF223 Gene

Publications for ZNF223 Gene

  1. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. (PMID: 12743021) Shannon M. … Stubbs L. (Genome Res. 2003) 3 4 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M. … Gstaiger M. (Cell Rep 2013) 3
  4. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for ZNF223 Gene

Sources for ZNF223 Gene

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