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Aliases for ZNF222 Gene

Aliases for ZNF222 Gene

  • Zinc Finger Protein 222 2 3 5

External Ids for ZNF222 Gene

Previous GeneCards Identifiers for ZNF222 Gene

  • GC19P045175
  • GC19P044921
  • GC19P049205
  • GC19P049221
  • GC19P044529
  • GC19P040961

Summaries for ZNF222 Gene

GeneCards Summary for ZNF222 Gene

ZNF222 (Zinc Finger Protein 222) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF229.

UniProtKB/Swiss-Prot for ZNF222 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF222 Gene

Genomics for ZNF222 Gene

Regulatory Elements for ZNF222 Gene

Enhancers for ZNF222 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF222 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF222 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF222 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF222 Gene

44,025,332 bp from pter
44,033,112 bp from pter
7,781 bases
Plus strand

Genomic View for ZNF222 Gene

Genes around ZNF222 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF222 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF222 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF222 Gene

Proteins for ZNF222 Gene

  • Protein details for ZNF222 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 222
    Protein Accession:
    Secondary Accessions:
    • G5E9B9
    • Q8N6G7
    • Q9P1U5

    Protein attributes for ZNF222 Gene

    451 amino acids
    Molecular mass:
    52484 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH30261.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF222 Gene


neXtProt entry for ZNF222 Gene

Proteomics data for ZNF222 Gene at MOPED

Post-translational modifications for ZNF222 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF222 Gene

No data available for DME Specific Peptides for ZNF222 Gene

Domains & Families for ZNF222 Gene

Gene Families for ZNF222 Gene

Protein Domains for ZNF222 Gene

Suggested Antigen Peptide Sequences for ZNF222 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 10 C2H2-type zinc fingers.
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 10 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF222: view

Function for ZNF222 Gene

Molecular function for ZNF222 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF222: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF222 Gene

Localization for ZNF222 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF222 Gene

Subcellular locations from

Jensen Localization Image for ZNF222 Gene COMPARTMENTS Subcellular localization image for ZNF222 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for ZNF222 Gene

Pathways & Interactions for ZNF222 Gene

SuperPathways for ZNF222 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF222: view

Pathways by source for ZNF222 Gene

2 Reactome pathways for ZNF222 Gene

Interacting Proteins for ZNF222 Gene

Gene Ontology (GO) - Biological Process for ZNF222 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF222: view

No data available for SIGNOR curated interactions for ZNF222 Gene

Drugs & Compounds for ZNF222 Gene

No Compound Related Data Available

Transcripts for ZNF222 Gene

Unigene Clusters for ZNF222 Gene

Zinc finger protein 222:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF222 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c
SP2: - -
SP3: - -
SP4: - - -

Relevant External Links for ZNF222 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF222 Gene

mRNA expression in normal human tissues for ZNF222 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF222 Gene

This gene is overexpressed in Serum (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF222 Gene

SOURCE GeneReport for Unigene cluster for ZNF222 Gene Hs.279840

genes like me logo Genes that share expression patterns with ZNF222: view

Protein tissue co-expression partners for ZNF222 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF222 Gene

Orthologs for ZNF222 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for ZNF222 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF222 35
  • 99.73 (n)
  • 99.39 (a)
ZNF222 36
  • 99 (a)
Species with no ortholog for ZNF222:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF222 Gene

Gene Tree for ZNF222 (if available)
Gene Tree for ZNF222 (if available)

Paralogs for ZNF222 Gene

(458) SIMAP similar genes for ZNF222 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF222: view

Variants for ZNF222 Gene

Sequence variations from dbSNP and Humsavar for ZNF222 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs11880330 - 44,031,822(+) GAGGC(A/G)AGATC reference, missense
rs7258517 - 44,031,846(+) AGACT(G/T)TTCCA reference, missense
rs8112679 - 44,032,462(+) ATGTG(A/G)TAAGA reference, missense
rs59926292 - 44,031,918(+) TAACC(A/G)GGTCT reference, missense
rs8100398 -- 44,029,191(+) gtttt(G/T)ttttt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF222 Gene

Variant ID Type Subtype PubMed ID
nsv469650 CNV Gain 16826518
nsv833840 CNV Gain 17160897

Variation tolerance for ZNF222 Gene

Residual Variation Intolerance Score: 96.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.13; 87.79% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF222 Gene

Disorders for ZNF222 Gene

Relevant External Links for ZNF222

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF222 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF222 Gene

Publications for ZNF222 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4 67
  2. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. (PMID: 12743021) Shannon M. … Stubbs L. (Genome Res. 2003) 3

Products for ZNF222 Gene

Sources for ZNF222 Gene