ZNF222 Gene
protein-coding GIFtS: 47
GCID: GC19P044529
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|
zinc finger protein 222
| |
Aliases
for ZNF222 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 2221 2 |
Export aliases for ZNF222 gene to outside databasesPrevious GC identifers: GC19P045175 GC19P044921 GC19P049205 GC19P049221 GC19P040961 |
Summaries
for ZNF222 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN222_HUMAN, Q9UK12Function: May be involved in transcriptional regulation
|
Genomic Views
for ZNF222 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for ZNF222
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF222
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF222 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.2 Ensembl cytogenetic band: 19q13.31 HGNC cytogenetic band: 19q13.2ZNF222 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P044529: view genomic region
(about GC identifiers)
Start:
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44,529,494 bp from pter |
End:
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44,537,265 bp from pter |
Size:
|
7,772 bases |
Orientation:
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plus strand |
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Proteins
for ZNF222 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN222_HUMAN, Q9UK12 (See
protein sequence)Recommended Name: Zinc finger protein 222 Size: 451 amino acids; 52484 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: Q9P1U5Explore the universe of human proteins at neXtProt for ZNF222: NX_Q9UK12
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UK12
ZNF222 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001123468.1 NP_037492.2
ENSEMBL proteins: ENSP00000466778 ENSP00000187879 ENSP00000375822 Reactome Protein details: Q9UK12
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZNF222 for ontologies About GeneDecksing
ZNF222 Antibody Products:
Assay Products for ZNF222: |
Protein
Domains /
Families
for ZNF222 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF222 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UK12ProtoNet protein and cluster: Q9UK12 1 Blocks protein family: IPB001909 KRAB box
UniProtKB/Swiss-Prot: ZN222_HUMAN, Q9UK12Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 10 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF222 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZN222_HUMAN, Q9UK12Function: May be involved in transcriptional regulation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF222 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF222 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): ZNF222 (NM_001129996) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF222 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF222 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZNF222 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZNF222 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF222
ZNF222 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF222
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for ZNF222 (ENSP000003758224) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF222 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF222 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF222
Search CenterWatch for drugs/clinical trials and news about ZNF222 / ZN222
|
Transcripts
for ZNF222 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF222 gene (2 alternative transcripts): NM_001129996.1 NM_013360.2 Unigene Cluster for ZNF222: Zinc finger protein 222 Hs.279840 [show with all ESTs]Unigene Representative Sequence: AK0951964 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000587846 ENST00000590160 ENST00000187879(uc002oyc.3) ENST00000391960(uc002oye.3 uc002oyd.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF222 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF222 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): ZNF222 (NM_001129996) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF222 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF222 |
Additional cDNA sequence: AF027145.1 AF187988.1 AK095196.1 BC030261.1 6 DOTS entries: DT.441179 DT.100017024 DT.100766076 DT.100811224 DT.95268623 DT.438925 24/142 AceView cDNA sequences (see all 142): AK056865 BM972262 AK095196 BC050340 AW629037 AW590200 AA743031 F03655 CA441594 AA743568 NM_003445 NM_198089 BX378595 AA360157 CB146324 BC030810 BQ000340 BX369128 AA235674 BX441408 AW071926 BX102147 BI753642 W60838
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF222 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | - | | | | | | | | |
| SP3: | | | | | | | - | | | | | | - | | | | | | | | | | |
| SP4: | | | | | | | - | | | | | | - | | - | | | | | | | |
ECgene alternative splicing isoforms for ZNF222
|
Expression
for ZNF222 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF222 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATATAATGT
About this image
See ZNF222 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF222
SOURCE GeneReport for Unigene cluster: Hs.279840
SABiosciences Custom PCR Arrays for ZNF222
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF222
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZNF222 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF222 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF222 |
Orthologs
for ZNF222 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for ZNF222 (if available)
TreeFam Gene Tree for ZNF222 (if available) |
Paralogs
for ZNF222 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF222 gene
- ZNF2292 ZNF2232 ZNF2302 ENSG000000623702 ZNF1552 ZNF6642 ZNF2272 ZNF2342
- ZNF2392 ZNF2242 ZNF2252 ZNF2262 ZNF2142 ZNF2842 ENSG000002671732 ZNF452
- ZNF2352 ZNF2212 ENSG000002670222 ZNF2852 ZNF2332
18/468 SIMAP similar genes for ZNF222 using alignment to 3 protein entries: ZN222_HUMAN (see all proteins)
(see all similar genes):ZNF230 ZNF223 ZNF224 ZNF155 ZNF226 ZNF225
ZNF55 ZNF234 ZNF221 ZNF596 MGC12518 ZNF229
POM121C ZNF471 ZNF506 HZF36 ZFS-6 ZNF789
ZNF222 for paralogs About GeneDecksing
|
Genomic Variants
for ZNF222 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF222 (44529494 - 44537265 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ZNF222
1 CNV: 2245 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF222 |
|
Disorders
/ Diseases
for ZNF222 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF222 for disorders About GeneDecksing
1  disease for ZNF222: About MalaCardsdigeorge syndrome
1 disease from the University of Copenhagen DISEASES database for ZNF222:DiGeorge syndrome Export disorders for ZNF222 gene to outside databases
|
Publications
for ZNF222 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF222 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF222) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
- Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. (PubMed id 12743021)1, 2 Shannon M.... Stubbs L. (2003)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- The identification and characterization of KRAB-domain-containing zinc finger proteins. (PubMed id 1559709)1 Constantinou-Deltas C.D.... Lee J.E. (1992)
|
External Searches for ZNF222 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF222 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF222 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF222 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF222 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF222 gene:
Search GeneIP for patents involving ZNF222
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF222 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF222 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF222 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF222 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF222 | | OriGene 3'-UTR Clone for ZNF222 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF222 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF222 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ZNF222 | | OriGene Custom Protein Services for ZNF222 | | | OriGene Custom Immunoassay Development | | |
| |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF222 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF222 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF222 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF222 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF222 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF222 |
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 |  |  |  | |
| | | | Search Tocris compounds for ZNF222 |
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 | | | ZNF222 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for ZNF222 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF222 |
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