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Aliases for ZNF222 Gene

Aliases for ZNF222 Gene

  • Zinc Finger Protein 222 2 3 5

External Ids for ZNF222 Gene

Previous GeneCards Identifiers for ZNF222 Gene

  • GC19P045175
  • GC19P044921
  • GC19P049205
  • GC19P049221
  • GC19P044529
  • GC19P040961

Summaries for ZNF222 Gene

GeneCards Summary for ZNF222 Gene

ZNF222 (Zinc Finger Protein 222) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ENSG00000267022.

UniProtKB/Swiss-Prot for ZNF222 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF222 Gene

Genomics for ZNF222 Gene

Regulatory Elements for ZNF222 Gene

Enhancers for ZNF222 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G043773 2.1 FANTOM5 Ensembl ENCODE dbSUPER 27.5 -245.4 -245431 12.4 CREB3L1 AGO1 YBX1 ZNF416 ZNF143 ZNF263 SP3 ZFP41 MEF2D ZNF610 ZNF225 ZNF45 ZNF180 LOC100505715 ZNF284 ZNF223 ZNF224 ZNF234 ZNF285 ZNF428
GH19G043686 1.7 FANTOM5 Ensembl ENCODE dbSUPER 14.2 -337.6 -337609 2.1 NFIB ZSCAN4 ZNF2 ZNF121 GLIS2 ZNF366 ZNF350 ZNF362 ZNF280D YY2 LOC100505715 ZNF45 ZNF225 ZNF285 LOC100379224 ENSG00000267191 PLAUR ZNF230 ZNF222 ZNF428
GH19G044740 2.1 FANTOM5 Ensembl ENCODE dbSUPER 10.5 +724.7 724686 19.4 CREB3L1 FEZF1 YBX1 YY1 ZNF143 ZNF548 ZNF263 SP3 TBX21 MEF2D ZNF225 ZNF45 ZNF284 ZNF155 ZNF224 ZNF223 ZNF180 RELB BCL3 LOC100505715
GH19G043462 1.5 Ensembl ENCODE dbSUPER 13.7 -560.8 -560800 3.6 HDGF PKNOX1 SIN3A YY1 ZNF416 FOS SP3 ZHX2 SMARCB1 ZNF579 ZNF225 ZNF284 ZNF223 ZNF575 XRCC1 ZNF45 LOC100505715 PHLDB3 ETHE1 LYPD3
GH19G044844 1.8 FANTOM5 ENCODE dbSUPER 10.5 +822.7 822683 7.3 CREB3L1 AGO1 YBX1 DMAP1 YY1 ZNF416 ZNF143 ZNF263 SP3 MCM3 ZNF180 ZNF45 LOC100505715 ZNF225 ZNF284 ZNF285 ZNF224 ZNF234 LOC100379224 ENSG00000267191
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF222 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF222 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000110022 469 1999 PKNOX1 CREB3L1 ARID4B DMAP1 YY1 ZNF302 ZNF143 FOS ZNF263 SP3

Genomic Location for ZNF222 Gene

Chromosome:
19
Start:
44,025,332 bp from pter
End:
44,033,112 bp from pter
Size:
7,781 bases
Orientation:
Plus strand

Genomic View for ZNF222 Gene

Genes around ZNF222 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF222 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF222 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF222 Gene

Proteins for ZNF222 Gene

  • Protein details for ZNF222 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UK12-ZN222_HUMAN
    Recommended name:
    Zinc finger protein 222
    Protein Accession:
    Q9UK12
    Secondary Accessions:
    • G5E9B9
    • Q8N6G7
    • Q9P1U5

    Protein attributes for ZNF222 Gene

    Size:
    451 amino acids
    Molecular mass:
    52484 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH30261.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF222 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF222 Gene

Post-translational modifications for ZNF222 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF222 Gene

No data available for DME Specific Peptides for ZNF222 Gene

Domains & Families for ZNF222 Gene

Gene Families for ZNF222 Gene

Protein Domains for ZNF222 Gene

Suggested Antigen Peptide Sequences for ZNF222 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UK12

UniProtKB/Swiss-Prot:

ZN222_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF222: view

Function for ZNF222 Gene

Molecular function for ZNF222 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF222 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF222: view
genes like me logo Genes that share phenotypes with ZNF222: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF222 Gene

Localization for ZNF222 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF222 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF222 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZNF222 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF222: view

Pathways & Interactions for ZNF222 Gene

SuperPathways for ZNF222 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF222: view

Pathways by source for ZNF222 Gene

2 Reactome pathways for ZNF222 Gene

Interacting Proteins for ZNF222 Gene

Gene Ontology (GO) - Biological Process for ZNF222 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF222: view

No data available for SIGNOR curated interactions for ZNF222 Gene

Drugs & Compounds for ZNF222 Gene

No Compound Related Data Available

Transcripts for ZNF222 Gene

Unigene Clusters for ZNF222 Gene

Zinc finger protein 222:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF222 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1:
SP2: - -
SP3: - -
SP4: - - -

Relevant External Links for ZNF222 Gene

GeneLoc Exon Structure for
ZNF222
ECgene alternative splicing isoforms for
ZNF222

Expression for ZNF222 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF222 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF222 Gene

This gene is overexpressed in Serum (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF222 Gene



Protein tissue co-expression partners for ZNF222 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF222 Gene:

ZNF222

SOURCE GeneReport for Unigene cluster for ZNF222 Gene:

Hs.279840

Evidence on tissue expression from TISSUES for ZNF222 Gene

  • Lung(4.2)
genes like me logo Genes that share expression patterns with ZNF222: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF222 Gene

Orthologs for ZNF222 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for ZNF222 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF222 34 35
  • 99.73 (n)
Species where no ortholog for ZNF222 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF222 Gene

ENSEMBL:
Gene Tree for ZNF222 (if available)
TreeFam:
Gene Tree for ZNF222 (if available)

Paralogs for ZNF222 Gene

(458) SIMAP similar genes for ZNF222 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF222: view

Variants for ZNF222 Gene

Sequence variations from dbSNP and Humsavar for ZNF222 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000046543 -- 44,026,003(+) GGTGT(G/T)TCACA intron-variant, upstream-variant-2KB
rs1000148116 -- 44,032,740(+) CAGGT(A/C)TTGAC reference, missense
rs1000160503 -- 44,026,397(+) GGAAC(A/G)GGTGG intron-variant, upstream-variant-2KB
rs1000436516 -- 44,032,375(+) GAAAT(A/G)TGGGA reference, missense
rs1001037153 -- 44,030,882(+) CACCC(C/T)CCATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF222 Gene

Variant ID Type Subtype PubMed ID
nsv469650 CNV gain 16826518
nsv833840 CNV gain 17160897
nsv961226 CNV duplication 23825009

Variation tolerance for ZNF222 Gene

Residual Variation Intolerance Score: 96.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.13; 87.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF222 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF222

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF222 Gene

Disorders for ZNF222 Gene

Relevant External Links for ZNF222

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF222

No disorders were found for ZNF222 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF222 Gene

Publications for ZNF222 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4 64
  2. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. (PMID: 12743021) Shannon M. … Stubbs L. (Genome Res. 2003) 3 4 64
  3. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3 64
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 64

Products for ZNF222 Gene

Sources for ZNF222 Gene

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