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ZNF222 Gene

protein-coding   GIFtS: 48
GCID: GC19P044529

Zinc Finger Protein 222

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 2221 2

External Ids:    HGNC: 130151   Entrez Gene: 76732   Ensembl: ENSG000001598857   UniProtKB: Q9UK123   

Export aliases for ZNF222 gene to outside databases

Previous GC identifers: GC19P045175 GC19P044921 GC19P049205 GC19P049221 GC19P040961


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF222 Gene:
ZNF222 (zinc finger protein 222) is a protein-coding gene. Diseases associated with ZNF222 include digeorge syndrome. An important paralog of this gene is ZNF229.

UniProtKB/Swiss-Prot: ZN222_HUMAN, Q9UK12
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NC_018930.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for ZNF222
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF222 promoter sequence
   Search Chromatin IP Primers for ZNF222

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF222


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.31   HGNC cytogenetic band: 19q13.2

ZNF222 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF222 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P044529:  view genomic region     (about GC identifiers)

Start:
44,529,494 bp from pter      End:
44,537,265 bp from pter
Size:
7,772 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ZN222_HUMAN, Q9UK12 (See protein sequence)
Recommended Name: Zinc finger protein 222  
Size: 451 amino acids; 52484 Da
Sequence caution: Sequence=AAH30261.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: G5E9B9 Q8N6G7 Q9P1U5
Alternative splicing: 2 isoforms:  Q9UK12-1   Q9UK12-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF222: NX_Q9UK12

Explore proteomics data for ZNF222 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF222 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001123468.1  NP_037492.2  

    ENSEMBL proteins: 
     ENSP00000466778   ENSP00000187879   ENSP00000375822  
    Reactome Protein details: Q9UK12

    ZNF222 Human Recombinant Protein Products:

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    LSBio Antibodies in human, mouse, rat for ZNF222

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    Cloud-Clone Corp. ELISAs for ZNF222
    Cloud-Clone Corp. CLIAs for ZNF222


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9UK12

    ProtoNet protein and cluster: Q9UK12

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN222_HUMAN, Q9UK12
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 10 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF222 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN222_HUMAN, Q9UK12
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    ZNF222 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF222
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZNF222
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZNF222

    miRNA
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat ZNF222

    Gene Editing
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    Clone
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    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZNF222
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF222

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF222


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN222_HUMAN, Q9UK12: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF222 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF222 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF222
        Generic Transcription Pathway



    ZNF222 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF222
    Interactions:

        Search GeneGlobe Interaction Network for ZNF222

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ZNF222 (ENSP000003758224) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    ZNF222 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF222 (ZN222)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZNF222 gene (2 alternative transcripts): 
    NM_001129996.1  NM_013360.2  

    Unigene Cluster for ZNF222:

    Zinc finger protein 222
    Hs.279840  [show with all ESTs]
    Unigene Representative Sequence: AK095196
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000587846 ENST00000590160 ENST00000187879(uc002oyc.3) ENST00000391960(uc002oye.3 uc002oyd.3)

    miRNA
    Products:
         
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    Search for qRT-PCR Assays for microRNAs that regulate ZNF222
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ZNF222
    Predesigned siRNA for gene silencing in human, mouse, rat ZNF222
    Clone
    Products:
         
    OriGene clones in human, mouse for ZNF222 (see all 12)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ZNF222 (NM_001129996)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZNF222
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF222
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ZNF222
    OriGene qSTAR qPCR primer pairs in human, mouse for ZNF222
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ZNF222
      QuantiTect SYBR Green Assays in human, mouse, rat ZNF222
      QuantiFast Probe-based Assays in human, mouse, rat ZNF222

    Additional mRNA sequence: 

    AF027145.1 AF187988.1 AK095196.1 BC030261.1 

    6 DOTS entries:

    DT.441179  DT.100017024  DT.100766076  DT.100811224  DT.95268623  DT.438925 

    Selected AceView cDNA sequences (see all 142):

    AA743568 BM972262 F03655 AW590200 AW629037 CA441594 AA743031 BC050340 
    AK056865 NM_198089 AK095196 NM_003445 AU100300 BX956294 AK090553 AF024701 
    NM_013360 AA236890 AA484991 BM972759 BQ184963 AA628632 AA664446 BX409806 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF222    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c
    SP1:                                                                  
    SP2:                                      -     -                     
    SP3:                    -                 -                           
    SP4:                    -                 -     -                     


    ECgene alternative splicing isoforms for ZNF222

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF222 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATATAATGT
    ZNF222 Expression
    About this image

    ZNF222 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF222 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.279840
        Custom PCR Arrays for ZNF222
    Primer
    Products:
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF222

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and chimp.

    Orthologs for ZNF222 gene from 1 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chimpanzee
    (Pan troglodytes)
    Mammalia ZNF2221 zinc finger protein 222 99.73(n)
    99.39(a)
      456102  XM_001158938.2  XP_001158938.1 


    ENSEMBL Gene Tree for ZNF222 (if available)
    TreeFam Gene Tree for ZNF222 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF222 gene
    ZNF2292  ZNF2232  ZNF2302  ZNF1552  ZNF2272  ZNF2242  ZNF2342  ZNF2252  
    ZNF2262  ZNF2142  ZNF2842  ENSG000002671732  ZNF452  ZNF2352  ZNF2212  ZNF2852  
    ENSG000002670222  ZNF1122  ZNF2332  
    Selected SIMAP similar genes for ZNF222 using alignment to 2 protein entries:     ZN222_HUMAN (see all proteins) (see all similar genes):
    ZNF230    ZNF155    ZNF223    ZNF224    ZNF625-ZNF20    ZNF225
    ZNF226    ZNF234    ZNF221    ZNF320    ZNF83    LOC101928664
    ZNF596    ZNF229    ZNF471    ZNF616    ZNF433    ZNF625

    ZNF222 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF222 (see all 264)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1459436061,2
    --44527500(+) AACACC/TATAGC 2 -- us2k10--------
    rs11137201,2
    C,F,H--44527665(+) aaataC/Tcagca 2 -- us2k1 tfbs38Minor allele frequency- T:0.09NS NA CSA WA 384
    rs1398419081,2
    --44527765(+) TATCAA/GTGTAA 2 -- us2k10--------
    rs1863486401,2
    --44527810(+) CATCAC/TGTCAG 2 -- us2k10--------
    rs1421266731,2
    --44527832(+) CATTCA/TGTTTC 2 -- us2k10--------
    rs751925981,2
    C,F--44527927(+) TATATA/CTGGAA 2 -- us2k11Minor allele frequency- C:0.02WA 118
    rs11137211,2
    C,H--44527952(+) ttgtcA/Gtactc 2 -- us2k12Minor allele frequency- G:0.00NS NA 122
    rs1478739031,2
    C--44528323(+) GGAAC-/TGTCTT 2 -- us2k10--------
    rs1886120211,2
    --44528417(+) CTTATA/GCCTGT 2 -- us2k10--------
    rs1391401101,2
    --44528418(+) TTATGC/TCTGTA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZNF222 (44529494 - 44537265 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ZNF222:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv469650CNV Gain16826518
    nsv833840CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF222
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF222

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for ZNF222:    
    About MalaCards
    digeorge syndrome

    1 disease from the University of Copenhagen DISEASES database for ZNF222:
    DiGeorge syndrome

    ZNF222 for disorders           About GeneDecksing


    Export disorders for ZNF222 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF222 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF222)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    2. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. (PubMed id 12743021)1, 2 Shannon M.... Stubbs L. (Genome Res. 2003)
    3. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    4. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    9. The identification and characterization of KRAB-domain-containing zinc finger proteins. (PubMed id 1559709)1 Constantinou-Deltas C.D.... Lee J.E. (Genomics 1992)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7673 HGNC: 13015 AceView: ZNF155andZNF230andZNF222 Ensembl:ENSG00000159885 euGenes: HUgn7673
    ECgene: ZNF222 H-InvDB: ZNF222

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF222 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF222 gene:
    Search GeneIP for patents involving ZNF222

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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Block miRNA regulation of human, mouse, rat ZNF222 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ZNF222
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