Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF222 Gene

Aliases for ZNF222 Gene

  • Zinc Finger Protein 222 2 3 5

External Ids for ZNF222 Gene

Previous GeneCards Identifiers for ZNF222 Gene

  • GC19P045175
  • GC19P044921
  • GC19P049205
  • GC19P049221
  • GC19P044529
  • GC19P040961

Summaries for ZNF222 Gene

GeneCards Summary for ZNF222 Gene

ZNF222 (Zinc Finger Protein 222) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ENSG00000267022.

UniProtKB/Swiss-Prot for ZNF222 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF222 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF222 Gene

Genomics for ZNF222 Gene

Regulatory Elements for ZNF222 Gene

Enhancers for ZNF222 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H043773 2 FANTOM5 Ensembl ENCODE dbSUPER 44.6 -245.4 -245431 12 YBX1 ZNF416 ZNF143 SP3 ZC3H11A ZFP41 MEF2D ZNF610 ZNF585B GLIS1 ZNF180 ZNF45 ZNF225 ZNF227 ZNF284 ZNF223 ZNF224 ZNF283 ZNF235 ZNF576
GH19H044111 1.5 FANTOM5 ENCODE 18.8 +87.7 87668 2 FOXA2 PKNOX1 ARNT ARID4B SIN3A ZNF2 YY1 ZNF766 ZNF302 ZNF416 ZNF45 ZNF180 ZNF225 ZNF224 ZNF227 ZNF155 ZNF234 XRCC1 ZNF283 ZNF576
GH19H043798 1.3 ENCODE dbSUPER 19.2 -226.3 -226315 1 ZNF133 ZNF2 ZNF121 GLIS2 ZNF416 KLF7 ZNF548 SP3 YY2 REST ZNF180 ZNF45 ZNF225 ZNF224 ZNF234 ZNF284 ZNF223 ZNF227 ZNF226 ZNF283
GH19H044740 2.1 FANTOM5 Ensembl ENCODE dbSUPER 10.5 +724.7 724686 19 YBX1 FEZF1 YY1 ZNF143 ZNF548 SP3 ZC3H11A MEF2D ZNF610 GLIS1 ZNF45 ZNF224 ZNF155 ZNF180 ZNF284 ZNF225 ZNF234 CLASRP ZNF235 ZNF283
GH19H043901 1.1 ENCODE 19.5 -123.5 -123480 1 SIN3A ARID4B ZNF2 YY1 ZNF766 ZNF302 ZNF416 ZNF143 ZNF548 SP3 ZNF45 ZNF180 ZNF225 ZNF224 ZNF234 ZNF284 ZNF227 ZNF235 ZNF226 XRCC1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF222 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF222 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000110022 469 1999 PKNOX1 ARID4B DMAP1 YY1 ZNF302 ZNF143 SP3 ZHX2 JUNB REST

Genomic Location for ZNF222 Gene

Chromosome:
19
Start:
44,025,332 bp from pter
End:
44,033,112 bp from pter
Size:
7,781 bases
Orientation:
Plus strand

Genomic View for ZNF222 Gene

Genes around ZNF222 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF222 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF222 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF222 Gene

Proteins for ZNF222 Gene

  • Protein details for ZNF222 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UK12-ZN222_HUMAN
    Recommended name:
    Zinc finger protein 222
    Protein Accession:
    Q9UK12
    Secondary Accessions:
    • G5E9B9
    • Q8N6G7
    • Q9P1U5

    Protein attributes for ZNF222 Gene

    Size:
    451 amino acids
    Molecular mass:
    52484 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH30261.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF222 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF222 Gene

Post-translational modifications for ZNF222 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF222 Gene

No data available for DME Specific Peptides for ZNF222 Gene

Domains & Families for ZNF222 Gene

Gene Families for ZNF222 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF222 Gene

Suggested Antigen Peptide Sequences for ZNF222 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UK12

UniProtKB/Swiss-Prot:

ZN222_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF222: view

Function for ZNF222 Gene

Molecular function for ZNF222 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF222 Gene

Gene Ontology (GO) - Molecular Function for ZNF222 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF222: view
genes like me logo Genes that share phenotypes with ZNF222: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZNF222
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF222 Gene

Localization for ZNF222 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF222 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF222 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF222 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF222: view

Pathways & Interactions for ZNF222 Gene

SuperPathways for ZNF222 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF222: view

Pathways by source for ZNF222 Gene

2 Reactome pathways for ZNF222 Gene

Interacting Proteins for ZNF222 Gene

Gene Ontology (GO) - Biological Process for ZNF222 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF222: view

No data available for SIGNOR curated interactions for ZNF222 Gene

Drugs & Compounds for ZNF222 Gene

No Compound Related Data Available

Transcripts for ZNF222 Gene

Unigene Clusters for ZNF222 Gene

Zinc finger protein 222:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZNF222
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF222 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1:
SP2: - -
SP3: - -
SP4: - - -

Relevant External Links for ZNF222 Gene

GeneLoc Exon Structure for
ZNF222
ECgene alternative splicing isoforms for
ZNF222

Expression for ZNF222 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF222 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF222 Gene

This gene is overexpressed in Serum (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF222 Gene



Protein tissue co-expression partners for ZNF222 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF222 Gene:

ZNF222

SOURCE GeneReport for Unigene cluster for ZNF222 Gene:

Hs.279840

Evidence on tissue expression from TISSUES for ZNF222 Gene

  • Lung(4.2)
genes like me logo Genes that share expression patterns with ZNF222: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF222 Gene

Orthologs for ZNF222 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for ZNF222 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF222 33 34
  • 99.73 (n)
Species where no ortholog for ZNF222 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF222 Gene

ENSEMBL:
Gene Tree for ZNF222 (if available)
TreeFam:
Gene Tree for ZNF222 (if available)

Paralogs for ZNF222 Gene

(458) SIMAP similar genes for ZNF222 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF222: view

Variants for ZNF222 Gene

Sequence variations from dbSNP and Humsavar for ZNF222 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000046543 -- 44,026,003(+) GGTGT(G/T)TCACA intron-variant, upstream-variant-2KB
rs1000148116 -- 44,032,740(+) CAGGT(A/C)TTGAC reference, missense
rs1000160503 -- 44,026,397(+) GGAAC(A/G)GGTGG intron-variant, upstream-variant-2KB
rs1000436516 -- 44,032,375(+) GAAAT(A/G)TGGGA reference, missense
rs1001037153 -- 44,030,882(+) CACCC(C/T)CCATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF222 Gene

Variant ID Type Subtype PubMed ID
nsv469650 CNV gain 16826518
nsv833840 CNV gain 17160897
nsv961226 CNV duplication 23825009

Variation tolerance for ZNF222 Gene

Residual Variation Intolerance Score: 96.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.13; 87.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF222 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF222

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF222 Gene

Disorders for ZNF222 Gene

Relevant External Links for ZNF222

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF222

No disorders were found for ZNF222 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF222 Gene

Publications for ZNF222 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 60
  2. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. (PMID: 12743021) Shannon M … Stubbs L (Genome research 2003) 3 4 60
  3. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L … Andersson-Svahn H (Molecular & cellular proteomics : MCP 2008) 3 60
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 60
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 60

Products for ZNF222 Gene

Sources for ZNF222 Gene

Content
Loading form....