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Aliases for ZNF221 Gene

Aliases for ZNF221 Gene

  • Zinc Finger Protein 221 2 3 5

External Ids for ZNF221 Gene

Previous GeneCards Identifiers for ZNF221 Gene

  • GC19P045100
  • GC19P044847
  • GC19P049131
  • GC19P049147
  • GC19P044271
  • GC19P044455

Summaries for ZNF221 Gene

GeneCards Summary for ZNF221 Gene

ZNF221 (Zinc Finger Protein 221) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF229.

UniProtKB/Swiss-Prot for ZNF221 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF221 Gene

Genomics for ZNF221 Gene

Regulatory Elements for ZNF221 Gene

Enhancers for ZNF221 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF221 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF221 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF221 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF221 Gene

43,951,223 bp from pter
43,967,709 bp from pter
16,487 bases
Plus strand

Genomic View for ZNF221 Gene

Genes around ZNF221 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF221 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF221 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF221 Gene

Proteins for ZNF221 Gene

  • Protein details for ZNF221 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 221
    Protein Accession:
    Secondary Accessions:
    • B2RAI6
    • Q2M2H2
    • Q9P1U8

    Protein attributes for ZNF221 Gene

    617 amino acids
    Molecular mass:
    71170 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF221 Gene

Proteomics data for ZNF221 Gene at MOPED

Post-translational modifications for ZNF221 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF221 Gene

No data available for DME Specific Peptides for ZNF221 Gene

Domains & Families for ZNF221 Gene

Gene Families for ZNF221 Gene

Protein Domains for ZNF221 Gene

Suggested Antigen Peptide Sequences for ZNF221 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 15 C2H2-type zinc fingers.
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 15 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF221: view

Function for ZNF221 Gene

Molecular function for ZNF221 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes for ZNF221 Gene

genes like me logo Genes that share phenotypes with ZNF221: view

Animal Model Products

CRISPR Products

miRNA for ZNF221 Gene

miRTarBase miRNAs that target ZNF221

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF221 Gene

Localization for ZNF221 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF221 Gene

Subcellular locations from

Jensen Localization Image for ZNF221 Gene COMPARTMENTS Subcellular localization image for ZNF221 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF221 Gene

Pathways & Interactions for ZNF221 Gene

SuperPathways for ZNF221 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF221: view

Pathways by source for ZNF221 Gene

2 Reactome pathways for ZNF221 Gene

Interacting Proteins for ZNF221 Gene

Gene Ontology (GO) - Biological Process for ZNF221 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF221: view

No data available for SIGNOR curated interactions for ZNF221 Gene

Drugs & Compounds for ZNF221 Gene

No Compound Related Data Available

Transcripts for ZNF221 Gene

mRNA/cDNA for ZNF221 Gene

(3) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF221 Gene

Zinc finger protein 221:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF221 Gene

No ASD Table

Relevant External Links for ZNF221 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF221 Gene

mRNA expression in normal human tissues for ZNF221 Gene

Protein differential expression in normal tissues from HIPED for ZNF221 Gene

This gene is overexpressed in Fetal Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF221 Gene

SOURCE GeneReport for Unigene cluster for ZNF221 Gene Hs.631598

genes like me logo Genes that share expression patterns with ZNF221: view

Protein tissue co-expression partners for ZNF221 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF221 Gene

Orthologs for ZNF221 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF221 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF221 35
  • 98.38 (n)
  • 96.76 (a)
ZNF221 36
  • 97 (a)
(Danio rerio)
Actinopterygii -- 35
Species with no ortholog for ZNF221:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF221 Gene

Gene Tree for ZNF221 (if available)
Gene Tree for ZNF221 (if available)

Paralogs for ZNF221 Gene

(499) SIMAP similar genes for ZNF221 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF221: view

Variants for ZNF221 Gene

Sequence variations from dbSNP and Humsavar for ZNF221 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_024201 -
VAR_024202 -
VAR_024203 -
VAR_033557 -
VAR_033558 -

Structural Variations from Database of Genomic Variants (DGV) for ZNF221 Gene

Variant ID Type Subtype PubMed ID
nsv469650 CNV Gain 16826518
nsv912109 CNV Loss 21882294

Variation tolerance for ZNF221 Gene

Residual Variation Intolerance Score: 98.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.91; 67.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF221 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF221 Gene

Disorders for ZNF221 Gene

Relevant External Links for ZNF221

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF221 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF221 Gene

Publications for ZNF221 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4 67
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3
  3. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. (PMID: 12743021) Shannon M. … Stubbs L. (Genome Res. 2003) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Coding region intron/exon organization, alternative splicing and X- chromosome inactivation of the KRAB/FPB-domain-containing human zinc finger gene ZNF41. (PMID: 10449920) Rosati M. … Grimaldi G. (Cytogenet. Cell Genet. 1999) 3

Products for ZNF221 Gene

Sources for ZNF221 Gene