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Aliases for ZNF221 Gene

Aliases for ZNF221 Gene

  • Zinc Finger Protein 221 2 3 5

External Ids for ZNF221 Gene

Previous GeneCards Identifiers for ZNF221 Gene

  • GC19P045100
  • GC19P044847
  • GC19P049131
  • GC19P049147
  • GC19P044271
  • GC19P044455

Summaries for ZNF221 Gene

GeneCards Summary for ZNF221 Gene

ZNF221 (Zinc Finger Protein 221) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF224.

UniProtKB/Swiss-Prot for ZNF221 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF221 Gene

Genomics for ZNF221 Gene

Regulatory Elements for ZNF221 Gene

Enhancers for ZNF221 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G043634 1.8 FANTOM5 Ensembl ENCODE dbSUPER 5.3 -315.6 -315635 2.7 ATF1 ZFP64 ARID4B DMAP1 GLIS2 ZNF263 KAT8 GLIS1 HNF4A PRDM4 ZNF225 ZNF45 PINLYP XRCC1 CADM4 ZNF155 IRGQ LYPD5 ZNF221 ZNF575
GH19G044111 1.5 FANTOM5 ENCODE 1.3 +161.8 161777 2.6 PKNOX1 FOXA2 CREB3L1 MLX ARNT SIN3A ARID4B ZNF2 YY1 ZNF766 ZNF45 ZNF180 ZNF225 ZNF224 ZNF234 ZNF155 ZNF284 LOC100379224 XRCC1 LOC100505715
GH19G043633 0.9 FANTOM5 dbSUPER 2.1 -317.4 -317389 0.1 ZNF362 ZNF366 CEBPA ZNF10 ATF2 PRDM1 CADM4 LYPD5 ZNF221 ZNF575 ZNF428 LOC105372410
GH19G044245 0.6 FANTOM5 2.6 +294.3 294340 0.3 ZBTB10 RBAK ADNP ZSCAN4 CHD1 RBBP5 ZBTB40 EZH2 ZNF226 ZNF229 ZNF112 ZNF285 ZNF221 ZNF227 ZNF233 ZNF235 LYPD5 ZNF234
GH19G044316 0.5 FANTOM5 2.8 +365.9 365911 0.3 KLF1 KLF17 ZNF233 ZNF229 ZNF112 ZNF221 ZNF285 ZNF223 ZNF284 ZNF180 ZNF227 PIR37551
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF221 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF221 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000110016 378 1599 CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF302
ENSR00000110016 378 1599 CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF302

Genomic Location for ZNF221 Gene

Chromosome:
19
Start:
43,951,223 bp from pter
End:
43,967,709 bp from pter
Size:
16,487 bases
Orientation:
Plus strand

Genomic View for ZNF221 Gene

Genes around ZNF221 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF221 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF221 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF221 Gene

Proteins for ZNF221 Gene

  • Protein details for ZNF221 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UK13-ZN221_HUMAN
    Recommended name:
    Zinc finger protein 221
    Protein Accession:
    Q9UK13
    Secondary Accessions:
    • B2RAI6
    • Q2M2H2
    • Q9P1U8

    Protein attributes for ZNF221 Gene

    Size:
    617 amino acids
    Molecular mass:
    71170 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF221 Gene

Post-translational modifications for ZNF221 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF221 Gene

Domains & Families for ZNF221 Gene

Gene Families for ZNF221 Gene

Protein Domains for ZNF221 Gene

Suggested Antigen Peptide Sequences for ZNF221 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UK13

UniProtKB/Swiss-Prot:

ZN221_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF221: view

Function for ZNF221 Gene

Molecular function for ZNF221 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF221 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IBA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF221: view

Phenotypes for ZNF221 Gene

genes like me logo Genes that share phenotypes with ZNF221: view

Animal Model Products

CRISPR Products

miRNA for ZNF221 Gene

miRTarBase miRNAs that target ZNF221

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF221 Gene

Localization for ZNF221 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF221 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF221 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF221 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with ZNF221: view

Pathways & Interactions for ZNF221 Gene

SuperPathways for ZNF221 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF221: view

Pathways by source for ZNF221 Gene

2 Reactome pathways for ZNF221 Gene

Interacting Proteins for ZNF221 Gene

Gene Ontology (GO) - Biological Process for ZNF221 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA,IEA --
genes like me logo Genes that share ontologies with ZNF221: view

No data available for SIGNOR curated interactions for ZNF221 Gene

Transcripts for ZNF221 Gene

mRNA/cDNA for ZNF221 Gene

Unigene Clusters for ZNF221 Gene

Zinc finger protein 221:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF221 Gene

No ASD Table

Relevant External Links for ZNF221 Gene

GeneLoc Exon Structure for
ZNF221
ECgene alternative splicing isoforms for
ZNF221

Expression for ZNF221 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF221 Gene

Protein differential expression in normal tissues from HIPED for ZNF221 Gene

This gene is overexpressed in Fetal Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF221 Gene



Protein tissue co-expression partners for ZNF221 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF221 Gene:

ZNF221

SOURCE GeneReport for Unigene cluster for ZNF221 Gene:

Hs.631598

Evidence on tissue expression from TISSUES for ZNF221 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZNF221: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF221 Gene

Orthologs for ZNF221 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF221 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF221 34 35
  • 98.38 (n)
zebrafish
(Danio rerio)
Actinopterygii -- 34
Species where no ortholog for ZNF221 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF221 Gene

ENSEMBL:
Gene Tree for ZNF221 (if available)
TreeFam:
Gene Tree for ZNF221 (if available)

Paralogs for ZNF221 Gene

(499) SIMAP similar genes for ZNF221 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF221: view

Variants for ZNF221 Gene

Sequence variations from dbSNP and Humsavar for ZNF221 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000377306 -- 43,967,411(+) CATCA(A/G)TTCTC upstream-variant-2KB, utr-variant-3-prime, utr-variant-5-prime
rs1000509019 -- 43,956,824(+) AAAAC(-/TG)TTAAA intron-variant
rs1000530153 -- 43,968,547(+) GAAAA(C/T)ATATT intron-variant, utr-variant-3-prime
rs1000533808 -- 43,961,224(+) TACAG(G/T)CTCAA intron-variant
rs1000964383 -- 43,968,865(+) CTTTG(A/C)AACCC intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF221 Gene

Variant ID Type Subtype PubMed ID
nsv1134794 CNV deletion 24896259
nsv469650 CNV gain 16826518
nsv579854 CNV loss 21841781
nsv960849 CNV duplication 23825009

Variation tolerance for ZNF221 Gene

Residual Variation Intolerance Score: 98.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.91; 67.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF221 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF221

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF221 Gene

Disorders for ZNF221 Gene

Relevant External Links for ZNF221

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF221

No disorders were found for ZNF221 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF221 Gene

Publications for ZNF221 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. (PMID: 12743021) Shannon M. … Stubbs L. (Genome Res. 2003) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for ZNF221 Gene

Sources for ZNF221 Gene

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