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Aliases for ZNF221 Gene

Aliases for ZNF221 Gene

  • Zinc Finger Protein 221 2 3

External Ids for ZNF221 Gene

Previous GeneCards Identifiers for ZNF221 Gene

  • GC19P045100
  • GC19P044847
  • GC19P049131
  • GC19P049147
  • GC19P044271
  • GC19P044455

Summaries for ZNF221 Gene

GeneCards Summary for ZNF221 Gene

ZNF221 (Zinc Finger Protein 221) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF155.

UniProtKB/Swiss-Prot for ZNF221 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF221 Gene

Genomics for ZNF221 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF221 Gene

43,951,223 bp from pter
43,967,709 bp from pter
16,487 bases
Plus strand

Genomic View for ZNF221 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF221 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF221 Gene

No data available for Regulatory Elements for ZNF221 Gene

Proteins for ZNF221 Gene

  • Protein details for ZNF221 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 221
    Protein Accession:
    Secondary Accessions:
    • B2RAI6
    • Q2M2H2
    • Q9P1U8

    Protein attributes for ZNF221 Gene

    617 amino acids
    Molecular mass:
    71170 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF221 Gene

Proteomics data for ZNF221 Gene at MOPED

Post-translational modifications for ZNF221 Gene

  • Ubiquitination at Lys280
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF221 Gene

No data available for DME Specific Peptides for ZNF221 Gene

Domains for ZNF221 Gene

Gene Families for ZNF221 Gene

  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF221 Gene

Suggested Antigen Peptide Sequences for ZNF221 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9UK13
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 15 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF221: view

Function for ZNF221 Gene

Molecular function for ZNF221 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF221 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF221: view

Phenotypes for ZNF221 Gene

GenomeRNAi human phenotypes for ZNF221:
genes like me logo Genes that share phenotypes with ZNF221: view

Animal Model Products

CRISPR Products

miRNA for ZNF221 Gene

miRTarBase miRNAs that target ZNF221

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF221 Gene

Localization for ZNF221 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF221 Gene

Subcellular locations from

Jensen Localization Image for ZNF221 Gene COMPARTMENTS Subcellular localization image for ZNF221 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF221 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF221: view

Pathways for ZNF221 Gene

SuperPathways for ZNF221 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF221: view

Pathways by source for ZNF221 Gene

2 Reactome pathways for ZNF221 Gene

Interacting Proteins for ZNF221 Gene

Gene Ontology (GO) - Biological Process for ZNF221 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF221: view

Transcripts for ZNF221 Gene

mRNA/cDNA for ZNF221 Gene

(3) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF221 Gene

Zinc finger protein 221:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF221

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ZNF221
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF221 Gene

No ASD Table

Relevant External Links for ZNF221 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF221 Gene

mRNA expression in normal human tissues for ZNF221 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZNF221 Gene

SOURCE GeneReport for Unigene cluster for ZNF221 Gene Hs.631598

genes like me logo Genes that share expressions with ZNF221: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF221 Gene

Orthologs for ZNF221 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF221 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF221 35
  • 98.38 (n)
  • 96.76 (a)
ZNF221 36
  • 97 (a)
(Danio rerio)
Actinopterygii -- 35
Species with no ortholog for ZNF221:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF221 Gene

Gene Tree for ZNF221 (if available)
Gene Tree for ZNF221 (if available)

Paralogs for ZNF221 Gene

Selected SIMAP similar genes for ZNF221 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF221: view

Variants for ZNF221 Gene

Sequence variations from dbSNP and Humsavar for ZNF221 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs47775 -- 43,959,184(-) aggaa(A/T)cttta intron-variant
rs367056 -- 43,958,598(-) atctt(A/C)aaatt intron-variant
rs367241 -- 43,952,802(-) GTTGA(C/T)AAAGT intron-variant
rs369958 -- 43,964,420(-) TACAT(A/G)CATTA intron-variant
rs373043 -- 43,959,320(-) aaata(C/T)accag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF221 Gene

Variant ID Type Subtype PubMed ID
nsv469650 CNV Gain 16826518
nsv912109 CNV Loss 21882294

Relevant External Links for ZNF221 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF221 Gene

Disorders for ZNF221 Gene

No disorders were found for ZNF221 Gene.

No data available for UniProtKB/Swiss-Prot for ZNF221 Gene

Publications for ZNF221 Gene

  1. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. (PMID: 12743021) Shannon M. … Stubbs L. (Genome Res. 2003) 3 4
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  5. Sumoylation of heterogeneous nuclear ribonucleoproteins, zinc finger proteins, and nuclear pore complex proteins: a proteomic analysis. (PMID: 15161980) Li T. … Chock P.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3

Products for ZNF221 Gene

Sources for ZNF221 Gene

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