ZNF22 Gene
protein-coding GIFtS: 48
GCID: GC10P045496
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zinc finger protein 22
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Aliases
for ZNF22 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 221 2 | | Zinc Finger Protein KOX152 3 | | KOX151 2 3 5 | | Zinc Finger Protein Krox-262 3 | | HKR-T11 2 | | Krox-26 Protein2 | | ZNF4221 2 | | Zinc Finger Protein 22 (KOX 15)2 | | Zfp4221 2 | | KROX263 |
Export aliases for ZNF22 gene to outside databasesPrevious GC identifers: GC10P044785 GC10P044964 GC10P045271 GC10P044779 GC10P044815 GC10P042021 |
Summaries
for ZNF22 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZNF22_HUMAN, P17026Function: Binds DNA through the consensus sequence 5'-CAATG-3'. May be involved in transcriptional regulation and mayplay a role in tooth formation (By similarity)
Gene Wiki entry for ZNF22
|
Genomic Views
for ZNF22 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_033985.7
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF22 gene promoter:
Bach1 RFX1 p53 ATF-2 Tal-1beta c-Rel FOXJ2 (long isoform) HFH-1 FOXJ2 ITF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF22
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF22 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q11 Ensembl cytogenetic band: 10q11.21 HGNC cytogenetic band: 10q11ZNF22 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P045496: view genomic region
(about GC identifiers)
Start:
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45,495,923 bp from pter |
End:
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45,500,777 bp from pter |
Size:
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4,855 bases |
Orientation:
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plus strand |
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Proteins
for ZNF22 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZNF22_HUMAN, P17026 (See
protein sequence)Recommended Name: Zinc finger protein 22 Size: 224 amino acids; 25915 Da
Subcellular location: Nucleus (By similarity)
Secondary accessions: Q5T741 Q96FM4Explore the universe of human proteins at neXtProt for ZNF22: NX_P17026
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P17026
ZNF22 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_008894.2
ENSEMBL proteins: ENSP00000298299
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
ZNF22 for ontologies About GeneDecksing
ZNF22 Antibody Products:
Assay Products for ZNF22: |
Protein
Domains /
Families
for ZNF22 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF22 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P17026ProtoNet protein and cluster: P17026 UniProtKB/Swiss-Prot: ZNF22_HUMAN, P17026Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 5 C2H2-type zinc fingers |
Function
for ZNF22 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZNF22_HUMAN, P17026Function: Binds DNA through the consensus sequence 5'-CAATG-3'. May be involved in transcriptional regulation and mayplay a role in tooth formation (By similarity) Genatlas biochemistry entry for ZNF22:zinc finger protein 22 (KOX15) (C2H2 type,Kruppel-like)
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF22
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF22 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
ZNF22 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for ZNF22:
|
Pathways & Interactions
for ZNF22 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF22
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
ZNF22 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF22 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF22
Search CenterWatch for drugs/clinical trials and news about ZNF22
|
Transcripts
for ZNF22 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF22 gene: NM_006963.4 Unigene Clusters for ZNF22: Zinc finger protein 22 Hs.462693 [show with all ESTs], Hs.655124 [show with all ESTs]Unigene Representative Sequences: BC041139, BC0261931 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000298299(uc001jbw.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF22 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF22
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF22 (NM_006963) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF22 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF22 |
Additional cDNA sequence: BC026193.1 9 DOTS entries: DT.418040 DT.100792834 DT.100792833 DT.100800733 DT.100792837 DT.121228393 DT.121228411 DT.121228425 DT.100792831 24/221 AceView cDNA sequences (see all 221): H89114 AA113952 BM799873 BQ897282 CA447313 AA807887 AI311718 F08396 BM893887 BU681909 AU280463 CB159846 AI128612 BU663659 AW298117 W77876 AA830690 BG504549 AA702615 BU753531 AI146980 AI472134 BI761317 BM801946
GeneLoc Exon Structure
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Expression
for ZNF22 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF22 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAAAACTAGG
About this image
See ZNF22 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF22
SOURCE GeneReport for Unigene clusters: Hs.462693 Hs.655124
UniProtKB/Swiss-Prot: ZNF22_HUMAN, P17026Tissue specificity: In the embryo, expressed in developing craniofacial structures including dental epithelium ofmaxillary molar tooth organs, tongue epithelium and muscle, and craniofacial bone osteoblasts. In the adult, expressedin mesoderm-derived tissues such as skeletal muscle, heart, kidney and liver. Intermediate expression in spleen,thymus and brain. Low levels in endoderm-derived tissues such as intestine and colon
SABiosciences Custom PCR Arrays for ZNF22
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF22
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNF22 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF22 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF22 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF22 |
Orthologs
for ZNF22 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZNF22 gene from 3/9 species (see all 9) About this table
ENSEMBL Gene Tree for ZNF22 (if available)
TreeFam Gene Tree for ZNF22 (if available) |
Paralogs
for ZNF22 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF22 gene
- ZFP922 ZNF32 ZNF7072
18/510 SIMAP similar genes for ZNF22 using alignment to 1 protein entry: ZNF22_HUMAN(see all similar genes):kr-znf3 DKFZp686N14223 ZSCAN9 ZNF286A ZNF286B ZNF78L1
ZFP41 ZNF773 ZNF3 ZNF530 ZNF549 ZNF569
ZNF658B ZNF761 ZNF DKFZp686O111 ZNF268 ZNF667
ZNF22 for paralogs About GeneDecksing
|
Genomic Variants
for ZNF22 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF22 (45495923 - 45500777 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF22: -- | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for ZNF22 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF22 for disorders About GeneDecksing
OMIM gene information: 194529
OMIM disorders: --
5  diseases for ZNF22: About MalaCardsmultiple endocrine neoplasia tooth agenesis sipple syndrome retinoblastoma
leukemia
1 disease from the University of Copenhagen DISEASES database for ZNF22:Tooth agenesis Export disorders for ZNF22 gene to outside databases
|
Publications
for ZNF22 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF22 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with ZNF22) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The human KROX-26/ZNF22 gene is expressed at sites of tooth formation and maps to the locus for permanent tooth agenesis (He-Zhao deficiency). (PubMed id 14630903)1, 2, 9 Gao Y.... Ganss B. (2003)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Isolation of a cDNA clone encoding a zinc finger protein highly expressed in T-leukemia lines. (PubMed id 1421376)1, 2 Wu B.Y.... Nabel G.J. (1992)
- Characterization and mapping of human genes encoding zinc finger proteins. (PubMed id 1946370)1, 2 Bray P.L.... Dawid I.B. (1991)
- Multiple genes encoding zinc finger domains are expressed in human T cells. (PubMed id 2288909)1, 2 Thiesen H.-J. (1990)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
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External Searches for ZNF22 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing ZNF22 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF22 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF22 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF22 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for ZNF22 gene:
Search GeneIP for patents involving ZNF22
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF22 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF22 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF22 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF22 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF22 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF22 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF22 |
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 | | | ZNF22 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF22 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF22 |
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