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Aliases for ZNF22 Gene

Aliases for ZNF22 Gene

  • Zinc Finger Protein 22 2 3
  • Zinc Finger Protein Krox-26 3 4
  • Zinc Finger Protein KOX15 3 4
  • KOX15 3 4
  • Zinc Finger Protein 22 (KOX 15) 3
  • Krox-26 Protein 3
  • ZNF422 3
  • HKR-T1 3
  • Zfp422 3
  • KROX26 4

External Ids for ZNF22 Gene

Previous GeneCards Identifiers for ZNF22 Gene

  • GC10P044785
  • GC10P045271
  • GC10P044779
  • GC10P044815
  • GC10P045496
  • GC10P042021

Summaries for ZNF22 Gene

GeneCards Summary for ZNF22 Gene

ZNF22 (Zinc Finger Protein 22) is a Protein Coding gene. Diseases associated with ZNF22 include x-linked intellectual disability, siderius type and tooth agenesis.

UniProtKB/Swiss-Prot for ZNF22 Gene

  • Binds DNA through the consensus sequence 5-CAATG-3. May be involved in transcriptional regulation and may play a role in tooth formation (By similarity).

Gene Wiki entry for ZNF22 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF22 Gene

Genomics for ZNF22 Gene

Regulatory Elements for ZNF22 Gene

Genomic Location for ZNF22 Gene

Chromosome:
10
Start:
45,000,475 bp from pter
End:
45,005,329 bp from pter
Size:
4,855 bases
Orientation:
Plus strand

Genomic View for ZNF22 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF22 Gene

Proteins for ZNF22 Gene

  • Protein details for ZNF22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17026-ZNF22_HUMAN
    Recommended name:
    Zinc finger protein 22
    Protein Accession:
    P17026
    Secondary Accessions:
    • Q5T741
    • Q96FM4

    Protein attributes for ZNF22 Gene

    Size:
    224 amino acids
    Molecular mass:
    25915 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF22 Gene

Proteomics data for ZNF22 Gene at MOPED

Post-translational modifications for ZNF22 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF22 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ZNF22 Gene

Domains & Families for ZNF22 Gene

Gene Families for ZNF22 Gene

Protein Domains for ZNF22 Gene

Suggested Antigen Peptide Sequences for ZNF22 Gene

Graphical View of Domain Structure for InterPro Entry

P17026

UniProtKB/Swiss-Prot:

ZNF22_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 5 C2H2-type zinc fingers.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 5 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF22: view

Function for ZNF22 Gene

Molecular function for ZNF22 Gene

GENATLAS Biochemistry:
zinc finger protein 22 (KOX15) (C2H2 type,Kruppel-like)
UniProtKB/Swiss-Prot Function:
Binds DNA through the consensus sequence 5-CAATG-3. May be involved in transcriptional regulation and may play a role in tooth formation (By similarity).

Gene Ontology (GO) - Molecular Function for ZNF22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding ISS --
GO:0008270 zinc ion binding TAS 1946370
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with ZNF22: view
genes like me logo Genes that share phenotypes with ZNF22: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF22 Gene

Localization for ZNF22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF22 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF22 Gene COMPARTMENTS Subcellular localization image for ZNF22 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for ZNF22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with ZNF22: view

Pathways & Interactions for ZNF22 Gene

SuperPathways for ZNF22 Gene

No Data Available

Interacting Proteins for ZNF22 Gene

Gene Ontology (GO) - Biological Process for ZNF22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 14630903
GO:0042476 odontogenesis NAS 14630903
genes like me logo Genes that share ontologies with ZNF22: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF22 Gene

Drugs & Compounds for ZNF22 Gene

No Compound Related Data Available

Transcripts for ZNF22 Gene

mRNA/cDNA for ZNF22 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(221) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF22 Gene

Zinc finger protein 22:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF22 Gene

No ASD Table

Relevant External Links for ZNF22 Gene

GeneLoc Exon Structure for
ZNF22
ECgene alternative splicing isoforms for
ZNF22

Expression for ZNF22 Gene

mRNA expression in normal human tissues for ZNF22 Gene

Protein differential expression in normal tissues from HIPED for ZNF22 Gene

This gene is overexpressed in NK cells (15.2), Tlymphocyte (14.8), and Peripheral blood mononuclear cells (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF22 Gene



SOURCE GeneReport for Unigene cluster for ZNF22 Gene Hs.462693

mRNA Expression by UniProt/SwissProt for ZNF22 Gene

P17026-ZNF22_HUMAN
Tissue specificity: In the embryo, expressed in developing craniofacial structures including dental epithelium of maxillary molar tooth organs, tongue epithelium and muscle, and craniofacial bone osteoblasts. In the adult, expressed in mesoderm-derived tissues such as skeletal muscle, heart, kidney and liver. Intermediate expression in spleen, thymus and brain. Low levels in endoderm-derived tissues such as intestine and colon.
genes like me logo Genes that share expression patterns with ZNF22: view

Protein tissue co-expression partners for ZNF22 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZNF22 Gene

Orthologs for ZNF22 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF22 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF22 35
  • 86.31 (n)
  • 89.29 (a)
dog
(Canis familiaris)
Mammalia ZNF22 35
  • 90.33 (n)
  • 94.64 (a)
ZNF22 36
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp422 35
  • 82.36 (n)
  • 86.55 (a)
Zfp422 16
Zfp422 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZNF22 35
  • 99.7 (n)
  • 100 (a)
ZNF22 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp422 35
  • 83.41 (n)
  • 86.1 (a)
oppossum
(Monodelphis domestica)
Mammalia ZNF22 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF22 36
  • 18 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF22 36
  • 29 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG4854 37
  • 45 (a)
Species with no ortholog for ZNF22:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF22 Gene

ENSEMBL:
Gene Tree for ZNF22 (if available)
TreeFam:
Gene Tree for ZNF22 (if available)

Paralogs for ZNF22 Gene

(517) SIMAP similar genes for ZNF22 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZNF22: view

No data available for Paralogs for ZNF22 Gene

Variants for ZNF22 Gene

Sequence variations from dbSNP and Humsavar for ZNF22 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs11471 -- 45,004,351(+) TTTTG(C/T)AGATA utr-variant-3-prime
rs11494 -- 45,004,773(+) TTCCT(A/G)CTAAT utr-variant-3-prime
rs3740092 -- 45,003,824(-) AGGTG(C/G)GAGCT reference, synonymous-codon
rs3740093 - 45,003,561(-) CTGAC(C/T)GAAAC reference, missense
rs11239310 -- 45,004,526(+) GTAGT(A/G)TATTA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF22 Gene

Variant ID Type Subtype PubMed ID
nsv831846 CNV Loss 17160897
nsv831848 CNV Gain 17160897

Variation tolerance for ZNF22 Gene

Residual Variation Intolerance Score: 64.66% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.31; 53.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF22 Gene

HapMap Linkage Disequilibrium report
ZNF22

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF22 Gene

Disorders for ZNF22 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZNF22 Gene - From: OMIM, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
x-linked intellectual disability, siderius type
  • mrxssd
tooth agenesis
  • hypodontia
- elite association
Search ZNF22 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ZNF22

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF22
genes like me logo Genes that share disorders with ZNF22: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF22 Gene

Publications for ZNF22 Gene

  1. Retinoblastoma protein (pRB) was significantly phosphorylated through a Ras-to-MAPK pathway in mutant K-ras stably transfected human adrenocortical cells. (PMID: 14611687) Chen Y.F. … Lin S.R. (DNA Cell Biol. 2003) 23 67
  2. The human KROX-26/ZNF22 gene is expressed at sites of tooth formation and maps to the locus for permanent tooth agenesis (He-Zhao deficiency). (PMID: 14630903) Gao Y. … Ganss B. (J. Dent. Res. 2003) 23 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 67

Products for ZNF22 Gene

Sources for ZNF22 Gene

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