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Aliases for ZNF22 Gene

Aliases for ZNF22 Gene

  • Zinc Finger Protein 22 2 3
  • KOX15 3 4 6
  • Zinc Finger Protein Krox-26 3 4
  • Zinc Finger Protein KOX15 3 4
  • Zinc Finger Protein 22 (KOX 15) 3
  • Krox-26 Protein 3
  • ZNF422 3
  • HKR-T1 3
  • Zfp422 3
  • KROX26 4

External Ids for ZNF22 Gene

Previous GeneCards Identifiers for ZNF22 Gene

  • GC10P044785
  • GC10P045271
  • GC10P044779
  • GC10P044815
  • GC10P045496
  • GC10P042021

Summaries for ZNF22 Gene

GeneCards Summary for ZNF22 Gene

ZNF22 (Zinc Finger Protein 22) is a Protein Coding gene.

UniProtKB/Swiss-Prot for ZNF22 Gene

  • Binds DNA through the consensus sequence 5-CAATG-3. May be involved in transcriptional regulation and may play a role in tooth formation (By similarity).

Gene Wiki entry for ZNF22 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF22 Gene

Genomics for ZNF22 Gene

Regulatory Elements for ZNF22 Gene

Genomic Location for ZNF22 Gene

45,000,475 bp from pter
45,005,329 bp from pter
4,855 bases
Plus strand

Genomic View for ZNF22 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF22 Gene

Proteins for ZNF22 Gene

  • Protein details for ZNF22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 22
    Protein Accession:
    Secondary Accessions:
    • Q5T741
    • Q96FM4

    Protein attributes for ZNF22 Gene

    224 amino acids
    Molecular mass:
    25915 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF22 Gene

Proteomics data for ZNF22 Gene at MOPED

Post-translational modifications for ZNF22 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF22 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF22 Gene

Domains for ZNF22 Gene

Gene Families for ZNF22 Gene

  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF22 Gene

Suggested Antigen Peptide Sequences for ZNF22 Gene

Graphical View of Domain Structure for InterPro Entry



  • P17026
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 5 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF22: view

Function for ZNF22 Gene

Molecular function for ZNF22 Gene

GENATLAS Biochemistry: zinc finger protein 22 (KOX15) (C2H2 type,Kruppel-like)
UniProtKB/Swiss-Prot Function: Binds DNA through the consensus sequence 5-CAATG-3. May be involved in transcriptional regulation and may play a role in tooth formation (By similarity).

Gene Ontology (GO) - Molecular Function for ZNF22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding ISS --
GO:0008270 zinc ion binding TAS 1946370
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with ZNF22: view

Phenotypes for ZNF22 Gene

GenomeRNAi human phenotypes for ZNF22:
genes like me logo Genes that share phenotypes with ZNF22: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF22 Gene

Localization for ZNF22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF22 Gene

Subcellular locations from

Jensen Localization Image for ZNF22 Gene COMPARTMENTS Subcellular localization image for ZNF22 gene
Compartment Confidence
nucleus 4
plasma membrane 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with ZNF22: view

Pathways for ZNF22 Gene

SuperPathways for ZNF22 Gene

No Data Available

Interacting Proteins for ZNF22 Gene

Gene Ontology (GO) - Biological Process for ZNF22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 14630903
GO:0042476 odontogenesis NAS 14630903
genes like me logo Genes that share ontologies with ZNF22: view

No data available for Pathways by source for ZNF22 Gene

Transcripts for ZNF22 Gene

mRNA/cDNA for ZNF22 Gene

(221) Selected AceView cDNA sequences:
(9) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF22 Gene

Zinc finger protein 22:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF22

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF22 Gene

No ASD Table

Relevant External Links for ZNF22 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF22 Gene

mRNA expression in normal human tissues for ZNF22 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF22 Gene

SOURCE GeneReport for Unigene cluster for ZNF22 Gene Hs.462693

mRNA Expression by UniProt/SwissProt for ZNF22 Gene

Tissue specificity: In the embryo, expressed in developing craniofacial structures including dental epithelium of maxillary molar tooth organs, tongue epithelium and muscle, and craniofacial bone osteoblasts. In the adult, expressed in mesoderm-derived tissues such as skeletal muscle, heart, kidney and liver. Intermediate expression in spleen, thymus and brain. Low levels in endoderm-derived tissues such as intestine and colon.
genes like me logo Genes that share expressions with ZNF22: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZNF22 Gene

Orthologs for ZNF22 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF22 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF22 35
  • 99.7 (n)
  • 100 (a)
ZNF22 36
  • 100 (a)
(Bos Taurus)
Mammalia ZNF22 35
  • 86.31 (n)
  • 89.29 (a)
(Canis familiaris)
Mammalia ZNF22 35
  • 90.33 (n)
  • 94.64 (a)
ZNF22 36
  • 70 (a)
(Mus musculus)
Mammalia Zfp422 35
  • 82.36 (n)
  • 86.55 (a)
Zfp422 16
Zfp422 36
  • 81 (a)
(Monodelphis domestica)
Mammalia ZNF22 36
  • 76 (a)
(Rattus norvegicus)
Mammalia Zfp422 35
  • 83.41 (n)
  • 86.1 (a)
(Gallus gallus)
Aves ZNF22 36
  • 18 (a)
(Anolis carolinensis)
Reptilia ZNF22 36
  • 29 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4854 37
  • 45 (a)
Species with no ortholog for ZNF22:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF22 Gene

Gene Tree for ZNF22 (if available)
Gene Tree for ZNF22 (if available)

Paralogs for ZNF22 Gene

Selected SIMAP similar genes for ZNF22 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZNF22: view

No data available for Paralogs for ZNF22 Gene

Variants for ZNF22 Gene

Sequence variations from dbSNP and Humsavar for ZNF22 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs11471 -- 45,004,351(+) TTTTG(C/T)AGATA utr-variant-3-prime
rs11494 -- 45,004,773(+) TTCCT(A/G)CTAAT utr-variant-3-prime
rs3740092 -- 45,003,824(-) AGGTG(C/G)GAGCT reference, synonymous-codon
rs3740093 - 45,003,561(-) CTGAC(C/T)GAAAC reference, missense
rs11239310 -- 45,004,526(+) GTAGT(A/G)TATTA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF22 Gene

Variant ID Type Subtype PubMed ID
nsv831846 CNV Loss 17160897
nsv831848 CNV Gain 17160897

Relevant External Links for ZNF22 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF22 Gene

Disorders for ZNF22 Gene

(1) University of Copenhagen DISEASES for ZNF22 Gene

genes like me logo Genes that share disorders with ZNF22: view

No data available for UniProtKB/Swiss-Prot for ZNF22 Gene

Publications for ZNF22 Gene

  1. The human KROX-26/ZNF22 gene is expressed at sites of tooth formation and maps to the locus for permanent tooth agenesis (He-Zhao deficiency). (PMID: 14630903) Gao Y. … Ganss B. (J. Dent. Res. 2003) 3 4 23
  2. Isolation of a cDNA clone encoding a zinc finger protein highly expressed in T-leukemia lines. (PMID: 1421376) Wu B.Y. … Nabel G.J. (Blood 1992) 3 4
  3. Characterization and mapping of human genes encoding zinc finger proteins. (PMID: 1946370) Bray P.L. … Dawid I.B. (Proc. Natl. Acad. Sci. U.S.A. 1991) 3 4
  4. Multiple genes encoding zinc finger domains are expressed in human T cells. (PMID: 2288909) Thiesen H.-J. (New Biol. 1990) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ZNF22 Gene

Sources for ZNF22 Gene

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