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Aliases for ZNF219 Gene

Aliases for ZNF219 Gene

  • Zinc Finger Protein 219 2 3 5
  • ZFP219 3

External Ids for ZNF219 Gene

Previous GeneCards Identifiers for ZNF219 Gene

  • GC14M018930
  • GC14M015345
  • GC14M019548
  • GC14M020628
  • GC14M021558
  • GC14M001678

Summaries for ZNF219 Gene

GeneCards Summary for ZNF219 Gene

ZNF219 (Zinc Finger Protein 219) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is ZNF516.

UniProtKB/Swiss-Prot for ZNF219 Gene

  • May be involved in transcriptional regulation.

Gene Wiki entry for ZNF219 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF219 Gene

Genomics for ZNF219 Gene

Regulatory Elements for ZNF219 Gene

Enhancers for ZNF219 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF219 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF219 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF219 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF219 Gene

21,090,046 bp from pter
21,104,722 bp from pter
14,677 bases
Minus strand

Genomic View for ZNF219 Gene

Genes around ZNF219 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF219 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF219 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF219 Gene

Proteins for ZNF219 Gene

  • Protein details for ZNF219 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 219
    Protein Accession:
    Secondary Accessions:
    • D3DS16
    • Q53Y57
    • Q8IYC1
    • Q9BW28

    Protein attributes for ZNF219 Gene

    722 amino acids
    Molecular mass:
    76877 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF219 Gene

Proteomics data for ZNF219 Gene at MOPED

Post-translational modifications for ZNF219 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for ZNF219 Gene

Domains & Families for ZNF219 Gene

Gene Families for ZNF219 Gene

Protein Domains for ZNF219 Gene

Suggested Antigen Peptide Sequences for ZNF219 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 6 C2H2-type zinc fingers.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 6 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF219: view

Function for ZNF219 Gene

Molecular function for ZNF219 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF219 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IDA 14621294
GO:0005515 protein binding IPI 19549071
genes like me logo Genes that share ontologies with ZNF219: view

Phenotypes for ZNF219 Gene

genes like me logo Genes that share phenotypes with ZNF219: view

Animal Model Products

CRISPR Products

miRNA for ZNF219 Gene

miRTarBase miRNAs that target ZNF219

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF219 Gene

Localization for ZNF219 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF219 Gene

Subcellular locations from

Jensen Localization Image for ZNF219 Gene COMPARTMENTS Subcellular localization image for ZNF219 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for ZNF219 Gene

Pathways & Interactions for ZNF219 Gene

SuperPathways for ZNF219 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF219 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IBA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0045892 negative regulation of transcription, DNA-templated IDA 14621294
genes like me logo Genes that share ontologies with ZNF219: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF219 Gene

Drugs & Compounds for ZNF219 Gene

(1) Drugs for ZNF219 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
histamine Pharma Full agonist, Agonist 999
genes like me logo Genes that share compounds with ZNF219: view

Transcripts for ZNF219 Gene

Unigene Clusters for ZNF219 Gene

Zinc finger protein 219:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF219 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g ^ 8 ^ 9
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - -
SP7: - -
SP8: - - - -
SP9: - -

Relevant External Links for ZNF219 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF219 Gene

mRNA expression in normal human tissues for ZNF219 Gene

Protein differential expression in normal tissues from HIPED for ZNF219 Gene

This gene is overexpressed in Gallbladder (67.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF219 Gene

SOURCE GeneReport for Unigene cluster for ZNF219 Gene Hs.250493

mRNA Expression by UniProt/SwissProt for ZNF219 Gene

Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with ZNF219: view

Protein tissue co-expression partners for ZNF219 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZNF219 Gene

Orthologs for ZNF219 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF219 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZNF219 35
  • 89.48 (n)
  • 92.88 (a)
ZNF219 36
  • 94 (a)
(Canis familiaris)
Mammalia ZNF219 35
  • 84.91 (n)
  • 86.31 (a)
ZNF219 36
  • 87 (a)
(Mus musculus)
Mammalia Zfp219 35
  • 82.89 (n)
  • 88.35 (a)
Zfp219 16
Zfp219 36
  • 88 (a)
(Pan troglodytes)
Mammalia ZNF219 35
  • 99.77 (n)
  • 99.86 (a)
ZNF219 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Zfp219 35
  • 83.36 (n)
  • 88.9 (a)
(Monodelphis domestica)
Mammalia ZNF219 36
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia ZNF219 36
  • 48 (a)
(Anolis carolinensis)
Reptilia ZNF219 36
  • 40 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495520 35
  • 52.47 (n)
  • 50.98 (a)
(Danio rerio)
Actinopterygii ZNF219 36
  • 38 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3642 36
  • 19 (a)
Species with no ortholog for ZNF219:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF219 Gene

Gene Tree for ZNF219 (if available)
Gene Tree for ZNF219 (if available)

Paralogs for ZNF219 Gene

Paralogs for ZNF219 Gene

genes like me logo Genes that share paralogs with ZNF219: view

Variants for ZNF219 Gene

Sequence variations from dbSNP and Humsavar for ZNF219 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs17853549 - 21,092,519(+) AGCTG(G/T)GGTCG reference, missense
rs8018832 -- 21,104,923(+) GGTAG(A/G)TGAGG upstream-variant-2KB
rs7149011 -- 21,094,401(+) AGGAT(C/T)CATCC intron-variant, reference, missense
rs8023143 -- 21,104,997(+) AGATA(C/T)TGCAT upstream-variant-2KB
rs3841049 -- 21,092,594(-) GCCTC(-/AGCCTC)CACCC cds-indel

Structural Variations from Database of Genomic Variants (DGV) for ZNF219 Gene

Variant ID Type Subtype PubMed ID
nsv826882 CNV Gain 20364138
dgv123n21 CNV Loss 19592680

Variation tolerance for ZNF219 Gene

Gene Damage Index Score: 9.78; 89.49% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF219 Gene

Disorders for ZNF219 Gene

Relevant External Links for ZNF219

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF219 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF219 Gene

Publications for ZNF219 Gene

  1. Isolation and characterization of a novel zinc finger gene, ZNF219, and mapping to the human chromosome 14q11 region. (PMID: 10819330) Sakai T. … Maeda H. (DNA Res. 2000) 2 3 4 67
  2. Functional dissection of the alpha-synuclein promoter: transcriptional regulation by ZSCAN21 and ZNF219. (PMID: 19549071) Clough R.L. … Stefanis L. (J. Neurochem. 2009) 3 23
  3. Identification of the DNA binding specificity of the human ZNF219 protein and its function as a transcriptional repressor. (PMID: 14621294) Sakai T. … Maeda H. (DNA Res. 2003) 3 23
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for ZNF219 Gene

Sources for ZNF219 Gene