ZNF219 Gene
protein-coding GIFtS : 51
GCID: GC14 M021558
zinc finger protein 219
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Aliasesfor ZNF219 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Zinc Finger Protein 219 1 2 ZFP2192
Export aliases for ZNF219 gene to outside databases Previous GC identifers: GC14M018930 GC14M015345 GC14M019548 GC14M020628 GC14M001678
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Summariesfor ZNF219 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: ZN219_HUMAN, Q9P2Y4 Function : May be involved in transcriptional regulationGene Wiki entry for ZNF219
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Genomic Viewsfor ZNF219 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000014.8 NC_018925.1 NT_026437.12 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ZNF219 gene promoter: Bach1 HOXA3 Pax-5 ARP-1 Nkx2-5 Other transcription factors Search SABiosciences Chromatin IP Primers for ZNF219 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat ZNF219
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 14q11 Ensembl cytogenetic band: 14q11.2 HGNC cytogenetic band: 14q11 ZNF219 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 14 GeneLoc Exon Structure
GeneLoc location for GC14M021558: view genomic region
(about GC identifiers )
Start:
21,558,205 bp from pter
End:
21,572,881 bp from pter
Size:
14,677 bases
Orientation:
minus strand
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Proteinsfor ZNF219 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: ZN219_HUMAN, Q9P2Y4 (See
protein sequence )Recommended Name: Zinc finger protein 219 Size : 722 amino acids; 76877 Da
Subcellular location : Nucleus
Secondary accessions : D3DS16 Q53Y57 Q8IYC1 Q9BW28Explore the universe of human proteins at neXtProt for ZNF219: NX_Q9P2Y4 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9P2Y4 ZNF219 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (3 alternative transcripts):
NP_001095142.1 NP_001095924.1 NP_057507.2 ENSEMBL proteins: ENSP00000354206 ENSP00000452530 ENSP00000388558 ENSP00000392401 ENSP00000450803 ENSP00000451212 ENSP00000450609 ENSP00000451890 ENSP00000450900 ENSP00000451969 ENSP00000451595 Human Recombinant Protein Products: Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view) : About this table
ZNF219 for ontologies About GeneDecksing ZNF219 Antibody Products: Assay Products for ZNF219:
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Protein
Domains / Familiesfor ZNF219 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
ZNF219 for domains About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q9P2Y4 ProtoNet protein and cluster: Q9P2Y4
UniProtKB/Swiss-Prot: ZN219_HUMAN, Q9P2Y4 Similarity : Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity : Contains 6 C2H2-type zinc fingers
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Functionfor ZNF219 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: ZN219_HUMAN, Q9P2Y4 Function : May be involved in transcriptional regulation
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ZNF219 (see all 5 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ZNF219 (see all 3 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 3 ): ZNF219 (NM_016423 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF219 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ZNF219
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF219
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6 ): About this table
ZNF219 for ontologies About GeneDecksing
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Pathways & Interactionsfor ZNF219 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF219 STRING Interaction
Network Preview (showing 5 interactants - click image to see 8)5/11 Interacting proteins for ZNF219 (Q9P2Y4 2 , 3 ENSP00000354206 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 11 )About this table Gene Ontology (GO): 3 biological process terms (GO ID links to tree view) : About this table
ZNF219 for ontologies About GeneDecksing
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Drugs & Compoundsfor ZNF219 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for ZNF219 1 HMDB Compound for ZNF219 About this table Search CenterWatch for drugs/clinical trials and news about ZNF219 / ZN219
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Transcriptsfor ZNF219 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for ZNF219 gene (3 alternative transcripts): NM_001101672.1 NM_001102454.1 NM_016423.2 Unigene Cluster for ZNF219:
Zinc finger protein 219 Hs.250493 [show with all ESTs ] Unigene Representative Sequence: NM_016423 14 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000360947 (uc001vzr.2 ) ENST00000555274 ENST00000451119 (uc010aik.1 )ENST00000421093 (uc001vzs.2 ) ENST00000555270 ENST00000554478 ENST00000556174 ENST00000554923 ENST00000553296 ENST00000553980 ENST00000556944 ENST00000555697 ENST00000556101 ENST00000557002 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ZNF219 (see all 5 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ZNF219 (see all 3 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 3 ): ZNF219 (NM_016423 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF219 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ZNF219
Additional cDNA sequence: AB015427.1 AK056261.1 AK225811.1 AK290700.1 BC000694.2 BC036105.1 BT006956.1
12 DOTS entries : DT.207630 DT.453832
DT.95323804 DT.97772508 DT.95078869 DT.100786987 DT.120747656 DT.40265259 DT.40300364 DT.75105751 DT.91902300 DT.97769855 24/112 AceView cDNA sequences (see all 112 ):
AI951725 AI368393 BF195112 CD366085 BM741830 BQ896631 BU684068 BX283600 CR610917 BX460320 BM765810 BM127126 AI927364 AI141124 AI935152 BP382571 BF439360 BU541146 BM783618 NM_016423 BF939838 BM128057 BM742314 CA393626 GeneLoc Exon Structure 5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF219 (see all 9 ) About this scheme ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g ^ 8 ^ 9 SP1 :           -   -   -   -   -     -   -                   SP2 :       -   -   -   -   -   -   -       -                   SP3 :       -   -     -   -   -   -     -   -                   SP4 :       -   -   -   -   -   -   -     -                     SP5 :       -   -   -   -   -   -   -     -   -                  
ECgene alternative splicing isoforms for ZNF219
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Expression for ZNF219 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section ZNF219 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GCCTTGCACC
About this image ZNF219 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See ZNF219 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ZNF219 SOURCE GeneReport for Unigene cluster: Hs.250493 UniProtKB/Swiss-Prot: ZN219_HUMAN, Q9P2Y4 Tissue specificity : Ubiquitous SABiosciences Custom PCR Arrays for ZNF219 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ZNF219Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat ZNF219 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ZNF219 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ZNF219 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF219
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Orthologsfor ZNF219 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for ZNF219 gene from 1/7 species (see all 7 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
zebrafish (Danio rerio)
Actinopterygii
BX664721.46
--
36(a)
1 ↔ 1
7(76614145-76617605)
ENSEMBL Gene Tree for ZNF219 (if available)TreeFam Gene Tree for ZNF219 (if available)
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Paralogsfor ZNF219 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for ZNF219 gene ZNF217 2 ZNF536 2 ZNF516 2 18/89 SIMAP similar genes for ZNF219 using alignment to 9 protein entries: ZN219_HUMAN (see all proteins )
(see all similar genes ):ZNF536 ZNF516 A-328A3.4 MAZ VEZF1 RREB1 ZFP1 ZFS-5 ZNF567 ZNF763 ZNF10 ZNF729 ZNF768 ZFX ZNF205 ZNF283 ZNF500 ZNF529
ZNF219 for paralogs About GeneDecksing
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Genomic Variantsfor ZNF219 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 14 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for ZNF219 (21558205 - 21572881 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for ZNF219: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ZNF219
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Disorders
/ Diseasesfor ZNF219 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
ZNF219 for disorders About GeneDecksing
OMIM gene information: 605036
OMIM disorders : --2 diseases for ZNF219 : About MalaCards intrahepatic cholangiocarcinoma cholangiocarcinoma Human Genome Epidemiology (HuGE) Navigator: ZNF219 (1 document)Export disorders for ZNF219 gene to outside databases
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Publicationsfor ZNF219 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for ZNF219 gene, integrated from 9 sources (see all 14 ): (articles sorted by number of sources associating them with ZNF219) Utopia : connect your pdf to the dynamic world of online information
Isolation and characterization of a novel zinc finger gene, ZNF219, and mapping to the human chromosome 14q11 region. (PubMed id 10819330) 1 , 2 , 3 Sakai T.... Maeda H. (2000) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Identification of the DNA binding specificity of the human ZNF219 protein and its function as a transcriptional repressor. (PubMed id 14621294) 1 , 9 Sakai T.... Maeda H. (2003) Functional dissection of the alpha-synuclein promoter : transcriptional regulation by ZSCAN21 and ZNF219. (PubMed id 19549071) 1 , 9 Clough R.L....Stefanis L. (2009) System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692) 2 Rigbolt K.T....Blagoev B. (2011) A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206) 1 Vinayagam A....Wanker E.E. (2011) The transcription factor Znf219 regulates chondrocyte differentiation by assembling a transcription factory with Sox9. (PubMed id 20940257) 1 Takigawa Y....Yoneda T. (2010) Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791) 1 Wang A.G....Kim N.S. (2006) Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983) 1 Olsen J.V....Mann M. (2006) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560) 1 Kimura K.... Sugano S. (2006)
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External Searches for ZNF219 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing ZNF219 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing ZNF219 gene
(According to HUGE )
About This Section --
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Specialized Databases showing ZNF219 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for ZNF219 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for ZNF219 gene: Search GeneIP for patents involving ZNF219 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor ZNF219 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for ZNF219 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for ZNF219 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ZNF219 Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for ZNF219 Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ZNF219 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ZNF219 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for ZNF219 OriGene Custom Protein Services for ZNF219 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF219 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ZNF219 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat ZNF219 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat ZNF219 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ZNF219 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ZNF219
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ZNF219 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF219
ThermoFisher Antibodies for ZNF219
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ZNF219
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Aliases for ZNF219
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