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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF219 Gene

protein-coding   GIFtS: 51
GCID: GC14M021558

zinc finger protein 219

 Explore 2 diseases affiliated with
ZNF219 via our new
 Human Malady Compendium 
Biological research products
for ZNF219
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Zinc Finger Protein 2191 2
ZFP2192

External Ids:    HGNC: 130111   Entrez Gene: 512222   Ensembl: ENSG000001658047   OMIM: 6050365   UniProtKB: Q9P2Y43   

Export aliases for ZNF219 gene to outside databases

Previous GC identifers: GC14M018930 GC14M015345 GC14M019548 GC14M020628 GC14M001678


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZN219_HUMAN, Q9P2Y4
Function: May be involved in transcriptional regulation

Gene Wiki entry for ZNF219


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF219 gene promoter:
         Bach1   HOXA3   Pax-5   ARP-1   Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF219 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF219

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF219


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11

ZNF219 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF219 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M021558:  view genomic region     (about GC identifiers)

Start:
21,558,205 bp from pter      End:
21,572,881 bp from pter
Size:
14,677 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZN219_HUMAN, Q9P2Y4 (See protein sequence)
Recommended Name: Zinc finger protein 219  
Size: 722 amino acids; 76877 Da
Subcellular location: Nucleus
Secondary accessions: D3DS16 Q53Y57 Q8IYC1 Q9BW28

Explore the universe of human proteins at neXtProt for ZNF219: NX_Q9P2Y4

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9P2Y4

  • ZNF219 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001095142.1  NP_001095924.1  NP_057507.2  

    ENSEMBL proteins: 
     ENSP00000354206   ENSP00000452530   ENSP00000388558   ENSP00000392401   ENSP00000450803  
     ENSP00000451212   ENSP00000450609   ENSP00000451890   ENSP00000450900   ENSP00000451969  
     ENSP00000451595  

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    Uscn Proteins for ZNF219

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA14621294
    GO:0016021integral to membrane IEA--


    ZNF219 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ZNF219 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2
     IPR003980 Histamine_H3_rcpt

    Graphical View of Domain Structure for InterPro Entry Q9P2Y4

    ProtoNet protein and cluster: Q9P2Y4

    UniProtKB/Swiss-Prot: ZN219_HUMAN, Q9P2Y4
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 6 C2H2-type zinc fingers


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ZN219_HUMAN, Q9P2Y4
    Function: May be involved in transcriptional regulation

    miRNA
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    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IDA14621294
    GO:0003700sequence-specific DNA binding transcription factor activity IDA19549071
    GO:0004969histamine receptor activity IEA--
    GO:0005515protein binding IPI19549071


    ZNF219 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF219

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/11 Interacting proteins for ZNF219 (Q9P2Y42, 3 ENSP000003542064) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SH3KBP1Q96B972, 3, ENSP000003809214MINT-8270682 I2D: score=2 STRING: ENSP00000380921
    BCL2L1Q078172, 3MINT-8249454 I2D: score=2 
    MAPK8P459832, 3MINT-8262363 I2D: score=2 
    SH3GL2Q999622, 3MINT-8270627 I2D: score=2 
    CTBP1Q133632, 3, ENSP000002909214MINT-8253913 I2D: score=2 STRING: ENSP00000290921
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IDA14621294
    GO:0006355regulation of transcription, DNA-dependent IMP19549071
    GO:0045892negative regulation of transcription, DNA-dependent IDA14621294


    ZNF219 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF219

    1 HMDB Compound for ZNF219    About this table
    CompoundSynonyms CAS #PubMed Ids
    Histamine1H-Imidazole-4-ethanamine (see all 27)51-45-6--
    Search CenterWatch for drugs/clinical trials and news about ZNF219 / ZN219 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF219 gene (3 alternative transcripts): 
    NM_001101672.1  NM_001102454.1  NM_016423.2  

    Unigene Cluster for ZNF219:

    Zinc finger protein 219
    Hs.250493  [show with all ESTs]
    Unigene Representative Sequence: NM_016423
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000360947(uc001vzr.2) ENST00000555274 ENST00000451119(uc010aik.1)
    ENST00000421093(uc001vzs.2) ENST00000555270 ENST00000554478 ENST00000556174
    ENST00000554923 ENST00000553296 ENST00000553980 ENST00000556944 ENST00000555697
    ENST00000556101 ENST00000557002

    miRNA
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    hsa-miR-3910 hsa-miR-3164 hsa-miR-126 hsa-miR-3194-5p hsa-miR-185* hsa-miR-2110 hsa-miR-134 hsa-miR-3150a-3p
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    Additional cDNA sequence: 

    AB015427.1 AK056261.1 AK225811.1 AK290700.1 BC000694.2 BC036105.1 BT006956.1 

    12 DOTS entries:

    DT.207630  DT.453832  DT.95323804  DT.97772508  DT.95078869  DT.100786987  DT.120747656  DT.40265259 
    DT.40300364  DT.75105751  DT.91902300  DT.97769855 

    24/112 AceView cDNA sequences (see all 112):

    AI951725 AI368393 BF195112 CD366085 BM741830 BQ896631 BU684068 BX283600 
    CR610917 BX460320 BM765810 BM127126 AI927364 AI141124 AI935152 BP382571 
    BF439360 BU541146 BM783618 NM_016423 BF939838 BM128057 BM742314 CA393626 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF219 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g ^ 8 ^ 9
    SP1:                                -     -     -     -     -           -     -                                                   
    SP2:                    -     -     -     -     -     -     -                 -                                                   
    SP3:                    -     -           -     -     -     -           -     -                                                   
    SP4:                    -     -     -     -     -     -     -           -                                                         
    SP5:                    -     -     -     -     -     -     -           -     -                                                   


    ECgene alternative splicing isoforms for ZNF219

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF219 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCCTTGCACC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    ZNF219 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    8 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Gut TubeMidgutMidgut Endoderm CellsEndoderm
    BrainMedulla OblongataBrain
    Gut TubeMidgutGut Tube
    Neural TubeDiencephalic Ventricular ZoneNeural Tube
    Neural TubeMesencephalic Ventricular ZoneNeural Tube
    Neural TubeMetencephalonNeural Tube
    Neural TubeTelencephalonNeural Tube
    Spinal CordPresumptive Spinal CordSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ZNF219 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF219

    SOURCE GeneReport for Unigene cluster: Hs.250493

    UniProtKB/Swiss-Prot: ZN219_HUMAN, Q9P2Y4
    Tissue specificity: Ubiquitous

        SABiosciences Custom PCR Arrays for ZNF219
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF219

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF219 gene from 1/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    zebrafish
    (Danio rerio)
    Actinopterygii BX664721.46
    --
    36(a)
    1 ↔ 1
    7(76614145-76617605)


    ENSEMBL Gene Tree for ZNF219 (if available)
    TreeFam Gene Tree for ZNF219 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF219 gene
    ZNF2172  ZNF5362  ZNF5162  
    18/89 SIMAP similar genes for ZNF219 using alignment to 9 protein entries:     ZN219_HUMAN (see all proteins) (see all similar genes):
    ZNF536    ZNF516    A-328A3.4    MAZ    VEZF1    RREB1
    ZFP1    ZFS-5    ZNF567    ZNF763    ZNF10    ZNF729
    ZNF768    ZFX    ZNF205    ZNF283    ZNF500    ZNF529

    ZNF219 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/241 NCBI SNPs in ZNF219 are shown (see all 241    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs801590451,2
    C,F,--1685489(+) AGGGAT/CAGATA 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs669955361,2
    C,F,--1685515(+) AAGCAG/ATAGGC 1 -- us2k15Minor allele frequency- A:0.21NA WA CSA 244
    rs1879391811,2
    --21557726(+) CTAGAA/GTAGTC 4 -- ut31 ds50010--------
    rs1919756071,2
    --21557737(+) CTCTGG/TATTAA 4 -- ut31 ds50010--------
    rs1844916061,2
    --21557814(+) GACTGA/GAAGGT 4 -- ds5001 ut310--------
    rs1421113421,2
    --21557850(+) GCTAGC/GTGACT 4 -- ds5001 ut310--------
    rs1891976071,2
    --21557883(+) GTCTCC/TTCCAC 4 -- ds5001 ut310--------
    rs1156871671,2
    C,F,--21557948(+) CTACTC/TCTTGA 4 -- ut31 ds50011Minor allele frequency- T:0.05WA 118
    rs1511800241,2
    --21558012(+) AATGAC/GGTCCT 4 -- ut31 ds50010--------
    rs1811923021,2
    --21558103(+) CCTGGG/TGGTAA 4 -- ds50010--------

    HapMap Linkage Disequilibrium report for ZNF219 (21558205 - 21572881 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ZNF219: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF219
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF219

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZNF219 for disorders           About GeneDecksing

    OMIM gene information: 605036    OMIM disorders: --

    2 diseases for ZNF219:    About MalaCards
    intrahepatic cholangiocarcinoma    cholangiocarcinoma

    Human Genome Epidemiology (HuGE) Navigator: ZNF219 (1 document)

    Export disorders for ZNF219 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF219 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with ZNF219)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of a novel zinc finger gene, ZNF219, and mapping to the human chromosome 14q11 region. (PubMed id 10819330)1, 2, 3 Sakai T.... Maeda H. (2000)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Identification of the DNA binding specificity of the human ZNF219 protein and its function as a transcriptional repressor. (PubMed id 14621294)1, 9 Sakai T.... Maeda H. (2003)
    4. Functional dissection of the alpha-synuclein promoter : transcriptional regulation by ZSCAN21 and ZNF219. (PubMed id 19549071)1, 9 Clough R.L....Stefanis L. (2009)
    5. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    6. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    7. The transcription factor Znf219 regulates chondrocyte differentiation by assembling a transcription factory with Sox9. (PubMed id 20940257)1 Takigawa Y....Yoneda T. (2010)
    8. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)1 Wang A.G....Kim N.S. (2006)
    9. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1 Olsen J.V....Mann M. (2006)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51222 HGNC: 13011 AceView: ZNF219 Ensembl:ENSG00000165804 euGenes: HUgn51222
    ECgene: ZNF219 H-InvDB: ZNF219

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF219 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for ZNF219 gene:
    Search GeneIP for patents involving ZNF219

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